KOBAYASHI Akira 小林聡

… Alternative Names

小林聡コバヤシアキラ

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Researcher Number	90334903
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2019: 信州大学, 学術研究院医学系, 准教授 2010 – 2013: 信州大学, 医学部, 准教授 2008: Shinshu University, 医学部・附属病院, 講師 2007 – 2008: Shinshu University, 医学部附属病院, 講師 2003: 信州大学, 医学部附属病院, 助手 2002: 信州大学, 医学部付属病院, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator 分化転換 / 再生医療 / 外科 / 臓器特異的幹細胞 / 肝組織内在性幹細胞 / 液性因子 / 組織特異的幹細胞 / 膵臓外科 / β細胞 / 糖尿病 … More / 転写因子 / インスリン産生細胞 / リプログラミング / 細胞間相互作用 / 遺伝子治療 / 消化器癌標的治療 / ペプチド / 肝細胞癌 / バイオパンニング法 / ZVAD-fmk / サイトカイン / apoptosis / 虚血再還流障害 / 肝 … More Except Principal Investigator 外科 / 肝再生 / NO誘導 / NOS / ALPPS / 化学療法 / オートファジー / 薬物療法 / 分子標的治療 / 抗癌剤治療 / 胆管癌 / 肝臓外科学 Less

Analysis of promoting factor of liver regeneration in ALPPS
- Principal Investigator
  
  Shimizu Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Isolation of hepatic progenitor cells using specific surface moleculesPrincipal Investigator
- Principal Investigator
  
  Kobyashi Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of a novel peptide-based therapy for cholangiocarcinoma
- Principal Investigator
  
  MIYAGAWA Shin-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
New modality for cell-replacement therapy using adult liver-derived progenitor cells for post-pancreatectomy diabetic patients.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
The analysis of liver-to-pancreas reprogramming based on cellular interactionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of anti-cancer drug modified by the peptide binding to Hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
脂肪肝ラットにおける肝虚血再還流障害のメカニズムに関する検討と臨床応用への試みPrincipal Investigator
- Principal Investigator
  
  小林聡
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University

All 2018 2012 2011 2009 2008 2007

All Journal Article Presentation

[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018
- Author(s)
  Motoyama Hiroaki、Kobayashi Akira、Yokoyama Takahide、Shimizu Akira、Sakai Hiroshi、Notake Tsuyoshi、Fukushima Kentaro、Miyagawa Shin-ichi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: e0197175-e0197175
- DOI
  10.1371/journal.pone.0197175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10665, KAKENHI-PROJECT-15K10160
[Journal Article] Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet2012
- Author(s)
  Akita S, Kobayashi A, Miyagawa S, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Issue: 4 Pages: 743-749
- DOI
  10.1016/j.bbrc.2012.03.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375, KAKENHI-PROJECT-22591516
[Journal Article] Essential role of gastric gland mucin in preventing gastric cancer in mice2012
- Author(s)
  Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J
- Journal Title
  
  J Clin Invest
  
  Volume: 122 Issue: 3 Pages: 923-934
- DOI
  10.1172/jci59087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390104, KAKENHI-PROJECT-21390375, KAKENHI-PROJECT-22591516, KAKENHI-PUBLICLY-24117710
[Journal Article] Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.2012
- Author(s)
  Gui A, Kobayashi A, Motoyama H, Kitazawa M, Takeoka M, Miyagawa S.
- Journal Title
  
  BMC Cancer
  
  Volume: 12 Issue: 1 Pages: 179-179
- DOI
  10.1186/1471-2407-12-179
- NAID
  120007108250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591516
[Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling2011
- Author(s)
  Takuma Arai, Teuhide Koyama, Takayuki Shindo, et al
- Journal Title
  
  peptides
  
  Volume: Volume32(9) Issue: 9 Pages: 1855-65
- DOI
  10.1016/j.peptides.2011.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07696, KAKENHI-PROJECT-11J10361, KAKENHI-PROJECT-21390375, KAKENHI-PROJECT-22591516, KAKENHI-PROJECT-23790288
[Journal Article] COP35, a cholangiocarcinoma-bindiag oligopeptide, interacts with the clathrin heavy chain accompanied by GRP782011
- Author(s)
  Kitahara H, Miyagawa S, et al
- Journal Title
  
  Mol Cancer Res
  
  Volume: 9 Issue: 6 Pages: 688-701
- DOI
  10.1158/1541-7786.mcr-10-0470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375, KAKENHI-PROJECT-22591516
[Journal Article] Clinical and pathological features of primary carcinoma of the cystic duct2009
- Author(s)
  Nakata T, Kobayashi A, Miwa S, Soeda J, Uehara T, Miyagawa S
- Journal Title
  
  J Hepatobiliary Pancreat Surg 16(1)
  
  Pages: 75-82
- NAID
  10025137871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009
- Author(s)
  清水明, 小林聡, 内川裕司, 三輪史郎, 宮川眞一
- Journal Title
  
  消化器外科 32巻2号
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009
- Author(s)
  清水明, 小林聡, 宮川償一, 他
- Journal Title
  
  消化器外科 32
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【処置と小手術のコツと合併症】基本手技総論腹腔穿刺2008
- Author(s)
  小林聡, 代田智樹, 宮川眞一
- Journal Title
  
  外科 70巻12号
  
  Pages: 1319-1322
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【再発肝癌診療におけるコンセンサスと個別化】再発時期の観点からみた再肝切除の成績2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 宮川雄輔, 大野康成, 清水明, 添田純平, 鈴木史恭, 秋田眞吾, 古澤徳彦, 増田雄一, 荒居琢磨
- Journal Title
  
  消化器科 47巻1号
  
  Pages: 81-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Primary liver carcinoma exhibiting dual hepatocellular-biliary epithelial differentiations associated with citrin deficiency : a case report2008
- Author(s)
  Soeda J, Yazaki M, Nakata T, Miwa S, Ikeda S, Hosoda W, Iijima M, Kobayashi K, Saheki T, Kojiro M, Miyagawa S
- Journal Title
  
  J Clin Gastroenterol 42(7)
  
  Pages: 855-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Identification of genes associated with multiple nodules in hepatocellular carcinoma using cDNA microarray : multicentric occurrence or intrahepatic metastasis?2008
- Author(s)
  Nakata T, Seki N, Miwa S, Kobayashi A, Soeda J, Nimura Y, Kawasaki S, Miyagawa S
- Journal Title
  
  Hepatogastroenterology 55(84)
  
  Pages: 865-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【処置と小手術のコツと合併症】基本手技総論腹腔穿刺2008
- Author(s)
  小林聡, 宮川屏一, 他
- Journal Title
  
  外科 70
  
  Pages: 1319-1322
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer2008
- Author(s)
  Noike T, Miwa S, Soeda J, Kobayashi A, Miyagawa S
- Journal Title
  
  Hum Pathol 39(2)
  
  Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Identification of genes associated with multiple nodules in hepatocellular carcinoma using cDNA microarray : multicentric occurrence or intrahepatic metastasis?2008
- Author(s)
  中田岳成, 小林聡, 宮川眞一, 他
- Journal Title
  
  Hepatogastroenterology 55
  
  Pages: 865-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【再発肝癌診療におけるコンセンサスと個別化】再発時期の観点からみた再肝切除の成績2008
- Author(s)
  小林聡, 宮川波一, 清水明, 他
- Journal Title
  
  消化器科 47
  
  Pages: 81-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Clinical and pathological features of primary carcinoma of the cystic duct.2008
- Author(s)
  中田岳成, 小林聡, 宮川眞一, 他
- Journal Title
  
  J Hepatobiliary Pancreat Surg 16
  
  Pages: 75-82
- NAID
  10025137871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Prognostic impact of anatomical resection on early and late intrahepatic recurrence in patients with hepatocellular carcinoma.2008
- Author(s)
  小林聡, 宮川眞一, 他
- Journal Title
  
  J Hepatobiliary Pancreat Surg 15
  
  Pages: 515-521
- NAID
  10024305908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Prognostic impact of anatomical resection on early and late intrahepatic recurrence in patients with hepatocellular carcinoma2008
- Author(s)
  Kobayashi A, Miyagawa S, Miwa S, Nakata T
- Journal Title
  
  J Hepatobiliary Pancreat Surg 15(5)
  
  Pages: 515-21
- NAID
  10024305908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy?2007
- Author(s)
  Miwa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Ogawa S, Soeda J, Miyagawa S
- Journal Title
  
  J Hepatobiliary Pancreat Surg 14(2)
  
  Pages: 136-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【肝細胞癌切除後の長期成績向上を目指して】初発病巣の治療系統的切除その適応と成績2007
- Author(s)
  小林聡, 宮川眞一, 三輪史郎
- Journal Title
  
  外科 69巻5号
  
  Pages: 511-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝門部胆管癌治癒切除後の再発部位と再発危険因子に関する検討2008
- Author(s)
  小林聡, 宮川屏一, 清水明, 他
- Organizer
  第20回日本肝胆膠外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 再発肝細胞癌に対する再肝切除の適応に関する検討2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 鈴木史恭, 古澤徳彦
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・ロイトン札幌
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝腫瘍占拠部位別の肝切除術の工夫と理論. 右肝静脈合併肝切除における後区域静脈還流温存のための工夫2008
- Author(s)
  清水明, 小林聡, 古澤徳彦, 鈴木史恭, 大野康成, 中田岳成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・北海道厚生年金会館
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝硬変合併肝細胞癌に対する系統的亜区域切除術の実際2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 添田純平, 鈴木史恭, 古沢徳彦,北川敬之, 野竹剛, 横井謙太
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎・NCC&スタジオ
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝門部胆管癌治癒切除後の再発部位と再発危険因子に関する検討2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 添田純平, 鈴木史恭, 秋田眞吾, 古沢徳彦, 増田雄一, 北川敬之, 野竹剛, 横井謙太
- Organizer
  第20回日本肝胆膵外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝腫瘍占拠部位別の肝切除術の工夫と理論右肝静脈合併肝切除における後区域静脈還流温存のための工夫2008
- Author(s)
  清水明, 小林聡, 宮川眞一, 他
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・北海道厚生年金会館
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 進行胆嚢癌に対する至適術式の検討2008
- Author(s)
  清水明, 小林聡, 中田岳成, 竹内大輔, 野竹剛, 北川敬之, 横井謙太, 古澤徳彦, 秋田眞吾, 鈴木史恭, 添田純平, 大野康成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎・長崎新聞文化ホール
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 進行胆嚢癌における予後因子と合併切除に関する検討2008
- Author(s)
  清水明, 小林聡, 中田岳成, 横井謙太, 野竹剛, 北川敬之, 秋田眞吾, 古澤徳彦, 鈴木史恭, 添田純平, 大野康成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第20回日本肝胆膵外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 再発肝癌診療におけるコンセンサスと個別化. 肝癌再発の危険因子と再肝切除の意義2007
- Author(s)
  小林聡, 宮川眞一, 三輪史郎
- Organizer
  2007年度日本消化器関連学会週間
- Place of Presentation
  神戸・神戸国際展示場
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝異時性多発癌に対する治療戦略2007
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 中田岳成, 三原基弘, 宮川雄輔, 小川真一郎, 清水明, 添田純平, 名取恵子
- Organizer
  第62回日本消化器外科学会定期学術総会
- Place of Presentation
  新宿・京王プラザホテル
- Year and Date
  2007-07-18
- Data Source
  KAKENHI-PROJECT-19591581

1. MIYAGAWA Shinichi (80229806)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MOTOYAMA Hiroaki (20569587)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. SHIMIZU Akira (00447773)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. 宮川幸昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 30 results
5. 中山淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Akira 小林 聡

小林 聡 コバヤシ アキラ

Research Projects

Research Products

Co-Researchers

Analysis of promoting factor of liver regeneration in ALPPS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation of hepatic progenitor cells using specific surface moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel peptide-based therapy for cholangiocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New modality for cell-replacement therapy using adult liver-derived progenitor cells for post-pancreatectomy diabetic patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of liver-to-pancreas reprogramming based on cellular interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-cancer drug modified by the peptide binding to Hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪肝ラットにおける肝虚血再還流障害のメカニズムに関する検討と臨床応用への試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential role of gastric gland mucin in preventing gastric cancer in mice2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] COP35, a cholangiocarcinoma-bindiag oligopeptide, interacts with the clathrin heavy chain accompanied by GRP782011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and pathological features of primary carcinoma of the cystic duct2009

Author(s)

KOBAYASHI Akira 小林聡

小林聡コバヤシアキラ

[Journal Article] 【処置と小手術のコツと合併症】基本手技総論腹腔穿刺2008