HATTORI Yoshiyuki 服部喜之

Researcher Number	90350222
Other IDs
External Links
Affiliation (Current)	2025: 星薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2024: 星薬科大学, 薬学部, 教授 2017 – 2022: 星薬科大学, 薬学部, 教授 2009 – 2016: Hoshi University, 薬学部, 准教授 2007 – 2008: Hoshi University, 薬学部, 講師 2005 – 2006: 星薬科大学, 医薬品化学研究所, 講師 2004: 星薬科大学, 医薬品化学研究所, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Physical pharmacy / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Drug development chemistry / Physical pharmacy
Keywords	Principal Investigator がん治療 / リポソーム / がん / siRNA / 葉酸受容体 / リポプレックス / コンドロイチン硫酸 / 肝転移がん / 抗がん薬 / 葉酸 … More / 遺伝子治療 / ワクチン / 脂質ナノ粒子 / mRNA / ターゲティング / がん細胞 / DDS / 転移がん / 正電荷リポソーム / ポリグルタミン酸 / 正電荷リポプレックス / ヒト乳がん / protein kinase N3 / 負電荷ポリマー / 抗がん剤 / ゾレドロン酸 / マクロファージ / リボソーム / 癌薬物送達システム / 癌治療 / 抗癌剤 / がん薬物送達システム / EPR効果 / 腫瘍ターゲティング / アンギオテンシンII / 昇圧化学療法 / ドラッグデリバリー / 炎症性サイトカイン / 活性化マクロファージ / 脂質微粒子遺伝子ベクター / NFκBデコイ核酸 / アトピー性皮膚炎 / リウマチ / チミジンキナーゼ / 葉酸レセプター / 遺伝子ベクター / 脂質微粒子製剤 / 抗癌治療 / 前立腺癌 … More Except Principal Investigator HDAC / ナノ粒子 / ヒストン脱アセチル化酵素阻害剤 / HDAC阻害剤 / ヒストン脱アセチル化酵素 / プロドラッグ / 抗がん剤 / 遺伝子発現 / 非ウイルスベクター / 正電荷ナノプレックス / 正電荷リポプレックス / コレステロール誘導体 / MADG / ITC / 小角散乱 / リポプレックス / 等温滴定型カロリメトリー / 小角X線散乱測定 / 脂質ナノ粒子 / 安定性 / 凍結乾燥 / 等温滴定型力ロリメトリー / 小角Ｘ線散乱 / siRNA / 脂質ナノ粒子複合体 / SAHA / Vorinostat / EPR効果 / PEG / 遺伝子導入 / リポフェクション / ナノプレックス / 遺伝子発現増強 / DNAナノプレックス / ドラッグデリバリーシステム / DDS / リポソーム / ナノパーティクル / 遺伝子ベクター Less

Development of mRNA lipid nanoparticles for tumor vaccinePrincipal Investigator
- Principal Investigator
  
  服部喜之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hoshi University
Development of folate-modified siRNA lipoplexes for tumor-targeting by intravenous injectionPrincipal Investigator
- Principal Investigator
  
  Hattori Yoshiyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hoshi University
Development of siRNA therapy for liver-metastasized tumor by sequential intravenous injection of chondroitin sulfate and siRNA lipoplexPrincipal Investigator
- Principal Investigator
  
  Hattori Yoshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
siRNA delivery to tumor by sequential injection of anionic polymer and siRNA lipoplexPrincipal Investigator
- Principal Investigator
  
  Hattori Yoshiyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Study on solid formulation of lipoplex using ionic liquid
- Principal Investigator
  
  Yonemochi Etsuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effect
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
Evaluation of antitumor effect of tumor-associated macrophage-targeting liposomesPrincipal Investigator
- Principal Investigator
  
  HATTORI Yoshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hoshi University
Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expression
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
Angiotensin II-induced hypertension enhanced delivery of liposomal anti-cancer drugs into tumorPrincipal Investigator
- Principal Investigator
  
  HATTORI Yoshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hoshi University
Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDS
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
デコイ核酸による炎症性疾患治療用炎症標的遺伝子ベクターの開発Principal Investigator
- Principal Investigator
  
  服部喜之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Hoshi University
前立腺癌標的自殺遺伝子治療のための葉酸修飾脂質微粒子ベクターシステムの開発Principal Investigator
- Principal Investigator
  
  服部喜之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hoshi University

[Journal Article] Effect of PEG anchor in PEGylation of folate-modified cationic liposomes with PEG-derivatives on systemic siRNA delivery into the Tumor2023
- Author(s)
  Tang Min、Sakasai Sho、Onishi Hiraku、Kawano Kumi、Hattori Yoshiyuki
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 31(1) Issue: 1 Pages: 74-88
- DOI
  10.1080/1061186x.2022.2104860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07142
[Journal Article] Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice2020
- Author(s)
  Hattori Yoshiyuki、Tamaki Kyoko、Sakasai Sho、Ozaki Kei-ichi、Onishi Hiraku
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 22(5) Pages: 4183-4196
- DOI
  10.3892/mmr.2020.11525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07142
[Journal Article] Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex.2019
- Author(s)
  Hattori Y, Nakamura M, Takeuchi N, Tamaki K, Shimizu S, Yoshiike, Y, Taguchi M, Ohno H, Ozaki K, Onishi H.
- Journal Title
  
  J. Drug Target.
  
  Volume: 27 Issue: 2 Pages: 217-227
- DOI
  10.1080/1061186x.2018.1502775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06694, KAKENHI-PROJECT-17K08251
[Journal Article] Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes.2019
- Author(s)
  Hattori Y, Tamaki K, Ozaki K, Kawano K, Onishi H.
- Journal Title
  
  J. Drug Deliv. Sci. Tec.
  
  Volume: 52 Pages: 1042-1050
- DOI
  10.1016/j.jddst.2019.06.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06694, KAKENHI-PROJECT-17K08251
[Journal Article] Effect of cationic lipid type in cationic liposomes for siRNA delivery into the liver by sequential injection of chondroitin sulfate and cationic lipoplex2018
- Author(s)
  Y. Hattori, N. Takeuchi, M. Nakamura, Y. Yoshiike, M. Taguchi, H. Ohno, K. Ozaki, H. Onishi,
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 48 Pages: 235-244
- DOI
  10.1016/j.jddst.2018.09.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08251, KAKENHI-PROJECT-18K06694
[Journal Article] Progress in the development of lipoplex and polyplex modified with anionic polymer for efficient gene delivery2017
- Author(s)
  Y. Hattori
- Journal Title
  
  Journal of Genetic Medicine and Gene Therapy
  
  Volume: 1 Pages: 3-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08251
[Journal Article] Small interfering RNA delivery into the liver by cationic cholesterol derivative-based liposomes2017
- Author(s)
  Y. Hattori, Y. Machida, M. Honda, N. Takeuchi, Y. Yoshiike, H. Ohno, H. Onishi
- Journal Title
  
  J. liposome Res.
  
  Volume: 印刷中 Issue: 4 Pages: 264-273
- DOI
  10.1080/08982104.2016.1205599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Evaluation of in vitro and in vivo therapeutic anti-tumor efficacy of transduction of polo-like kinase 1 and heat shock transcription factor 1 small interfering RNA2017
- Author(s)
  Y. Hattori, T. Kikuchi, K. Ozaki, H. Onishi
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 14 Pages: 4300-4306
- DOI
  10.3892/etm.2017.5060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08251, KAKENHI-PROJECT-15K08075
[Journal Article] Therapeutic effects of protein kinase N3 small interfering RNA and doxorubicin combination therapy on liver and lung metastases2017
- Author(s)
  Y. Hattori, T. Kikuchi, M. Nakamura, K. Ozaki, H. Onishi
- Journal Title
  
  Oncol. Lett.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Effect of chondroitin sulfate on siRNA biodistribution and gene silencing effect in mice after injection of siRNA lipoplexes2017
- Author(s)
  Y. Hattori, A. Nakamura, S. Hanaya, Y. Miyanabe, Y. Yoshiike, T. Kikuchi, K. Ozaki, H. Onishi
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 41 Pages: 401-409
- DOI
  10.1016/j.jddst.2017.08.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08251, KAKENHI-PROJECT-15K08075
[Journal Article] Evaluation of injection route of anionic polymer for siRNA delivery into the liver by sequential injection of anionic polymer and cationic lipoplex of siRNA2016
- Author(s)
  Y. Hattori, Y. Yoshiike, T. Kikuchi, N. Yamamoto, K. Ozaki, H. Onishi
- Journal Title
  
  J. Drug Deliv. Sci. Tec.
  
  Volume: 35 Pages: 40-49
- DOI
  10.1016/j.jddst.2016.05.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Delivery of plasmid DNA into tumors by intravenous injection of PEGylated cationic lipoplexes into tumor-bearing mice2016
- Author(s)
  Y. Hattori
- Journal Title
  
  Pharmacology & Pharmacy
  
  Volume: 7 (7) Issue: 07 Pages: 272-282
- DOI
  10.4236/pp.2016.77034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Tumor delivery of liposomal doxorubicin prepared with poly-L-glutamic acid as a drug-trapping agent2016
- Author(s)
  Andang Miatmoko, Kumi Kawano, Hitomi Yoda, Etsuo Yonemochi, Yoshiyuki Hattori
- Journal Title
  
  Journal of Liposome Research
  
  Volume: 27 Issue: 2 Pages: 1-9
- DOI
  10.3109/08982104.2016.1166511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460048
[Journal Article] Therapeutic effect for liver-metastasized tumor by sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA2016
- Author(s)
  Y. Hattori, S. Arai, T. Kikuchi, K. Ozaki, K. Kawano, E. Yonemochi
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 24 (4) Issue: 4 Pages: 309-317
- DOI
  10.3109/1061186x.2015.1070856
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] siRNA Delivery into Tumor Cells by Cationic Cholesterol Derivative-Based Nanoparticles and Liposomes2015
- Author(s)
  Y. Hattori, E. Hara, Y. Shingu, D. Minamiguchi, A. Nakamura, S. Arai, H. Ohno, K. Kawano, N. Fujii, E. Yonemochi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 1 Pages: 30-38
- DOI
  10.1248/bpb.b14-00526
- NAID
  130004872237
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Optimization of siRNA delivery method into the liver by sequential injection of polyglutamic acid and cationic lipoplex2015
- Author(s)
  Y. Hattori, S. Arai, T. Kikuchi, M. Hamada, R. Okamoto, Y. Machida and K. Kawano
- Journal Title
  
  Pharmacology & Pharmacy
  
  Volume: 6 (7) Issue: 07 Pages: 302-310
- DOI
  10.4236/pp.2015.67032
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] siRNA Delivery into Tumor Cells by Cationic Cholesterol Derivative Based Nanoparticles and Liposomes2015
- Author(s)
  Yoshiyuki Hattori, Eriko Hara Yumiko Shingu, Daiki Minamiguchi, Ayako Nakamuraj, Shohei Araij Hiroaki Ohno, Kumi Kawano, Nobutaka Fujii, and Etsuo Yonemochi
- Journal Title
  
  Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．
  
  Volume: 38 Pages: 30-38
- NAID
  130004872237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460048
[Journal Article] siRNA delivery to lung-metastasized tumor by systemic injection with cationic liposome2015
- Author(s)
  Y. Hattori, A. Nakamura, S. Arai, K. Kawano, Y. Maitani, E. Yonemochi
- Journal Title
  
  Journal of Liposome Research
  
  Volume: 25 (4) Issue: 4 Pages: 279-286
- DOI
  10.3109/08982104.2014.992024
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] Sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA could effectively deliver siRNA to the liver2014
- Author(s)
  Y. Hattori, S. Arai, R. Okamoto, M. Hamada, K. Kawano, E. Yonemochi
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 476 Issue: 1-2 Pages: 289-298
- DOI
  10.1016/j.ijpharm.2014.09.059
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460046
[Journal Article] In vivo siRNA delivery system for targeting to the liver by poly-L-glutamic acid-coated lipoplex2014
- Author(s)
  Y. Hattori, A. Nakamura, S. Arai, M. Nishigaki, H. Ohkura, K. Kawano, Y. Maitani and E. Yonemochi
- Journal Title
  
  Results in Pharma Sciences
  
  Volume: 4 Pages: 1-7
- DOI
  10.1016/j.rinphs.2014.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] siRNA delivery for tumor by lipid-based nanoparticle composed with hydroxyethylated cholesteryl triamine2013
- Author(s)
  Y. Hattori, T. Nakamura, H, Ohno, N. Fujii, Y. Maitani
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 443 Issue: 1-2 Pages: 221-229
- DOI
  10.1016/j.ijpharm.2012.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Transdermal delivery of small interfering RNA with elastic cationic liposomes in mice2013
- Author(s)
  Y. Hattori, M. Date, S. Arai, K. Kawano, E. Yonemochi, Y. Maitani
- Journal Title
  
  Journal of Pharmaceutics
  
  Volume: 2013 Pages: 149695-149695
- DOI
  10.1155/2013/149695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine2013
- Author(s)
  Y. Hattori, T. Nakamura, H, Ohno, N. Fujii, Y. Maitani
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 5 Pages: 856-860
- DOI
  10.1248/bpb.b12-01062
- NAID
  130003361415
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma2013
- Author(s)
  K. Kawano, Y. Hattori, H. Iwakura, T. Akamizu and Y. Maitani
- Journal Title
  
  Cancer Medicine
  
  Volume: 2(3) Issue: 3 Pages: 286-295
- DOI
  10.1002/cam4.76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590054, KAKENHI-PROJECT-23790203
[Journal Article] Anionic polymer-coated lipoplex for safe gene delivery into tumor by systemic injection2013
- Author(s)
  Y. Hattori, H. Yamasaku, Y. Maitani
- Journal Title
  
  J. Drug Target
  
  Volume: 21(7) Issue: 7 Pages: 639-647
- DOI
  10.3109/1061186x.2013.789035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex2012
- Author(s)
  M. Kato, Y. Hattori, M. Kubo and Y. Maitani
- Journal Title
  
  Int. J. Pharm
  
  Volume: 423(2) Issue: 2 Pages: 428-434
- DOI
  10.1016/j.ijpharm.2011.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Early entry and deformation of macropinosomes correlates with high efficiency of decaarginine-PEG-lipid-mediated gene delivery2012
- Author(s)
  Kobayashi, S.
- Journal Title
  
  J.Gene Med.
  
  Volume: 14 Issue: 4 Pages: 262-271
- DOI
  10.1002/jgm.2615
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20114001, KAKENHI-PLANNED-20114002, KAKENHI-PROJECT-21370094, KAKENHI-PROJECT-22770205, KAKENHI-PROJECT-23247003, KAKENHI-PROJECT-23790203
[Journal Article] Involvement of transcription factor Ets-1 in the expression of the α3 integrin subunit gene.2012
- Author(s)
  Kamoshida G, Matsuda A, Katabami K, Kato T, Mizuno H, Sekine W, Oku T, Itoh S, Tsuiji M, Hattori Y, Maitani Y, Tsuji T.
- Journal Title
  
  FEBS J.
  
  Volume: 279(24) Issue: 24 Pages: 4535-46
- DOI
  10.1111/febs.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590115, KAKENHI-PROJECT-23590092, KAKENHI-PROJECT-23790203
[Journal Article] Adrenal tumor volume in a genetically engineered mouse model of neuroblastoma determined by magnetic resonance imaging2012
- Author(s)
  K. Kawano, Y. Hattori, H. Iwakura, T. Akamizu, Y. Maitani
- Journal Title
  
  Exp. Ther. Med.
  
  Volume: 4 Issue: 1 Pages: 61-64
- DOI
  10.3892/etm.2012.564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203, KAKENHI-PROJECT-23791052, KAKENHI-PUBLICLY-23126510
[Journal Article] Angiotensin II-induced hypertension enhanced therapeutic efficacy of liposomal doxorubicin in tumor-bearing mice2011
- Author(s)
  Y.Hattori, H.Ubukata, K.Kawano, Y.Maitani
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 403 Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Angiotensin II-induced hypertension enhanced therapeutic efficacy of liposomal doxorubicin in tumor-bearing mice2011
- Author(s)
  Y.Hattori, H.Ubukata, K.Kawano, Y.Maitani
- Journal Title
  
  Int J Pharm. 403
  
  Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro2011
- Author(s)
  Y. Hattori, Y. Nagaoka, M. Kubo, H. Yamasaku, Y. Ishii, S. Uesato, Y. Maitani
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 59(11) Pages: 1386-1392
- NAID
  130001274814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Cell line-dependent internalization pathways determine DNA transfecti on efficiency of decaarginine-PEG-lipid2011
- Author(s)
  T.Izumisawa, Y.Hattori, M.Date, K.Toma, Y.Maitani
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 404 Pages: 264-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Antitumor Effect of Liposomal Histone Deacetylase Inhibitor-Lipid Conjugates in Vitro2011
- Author(s)
  Y.Hattori, Y.Nagaoka, Shinichi Uesato, 他4名
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 59 Issue: 11 Pages: 1386-1392
- DOI
  10.1248/cpb.59.1386
- NAID
  130001274814
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131, KAKENHI-PROJECT-23790203
[Journal Article] Cell line-dependent internalization pathways determine DNA transfection efficiency of decaarginine-PEG-lipid2011
- Author(s)
  T. Izumisawa, Y. Hattori, M. Date, K. Toma, Y. Maitani
- Journal Title
  
  The International Journal of Pharmaceutics
  
  Volume: 404 Issue: 1-2 Pages: 264-270
- DOI
  10.1016/j.ijpharm.2010.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790203
[Journal Article] Molecular characterization of tumors from a transgenic mice adrenal tumor model : Comparison with human pheochromocytoma2010
- Author(s)
  Y.Hattori, N.Kanamoto, et al.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 37 Pages: 695-705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Combination of RET siRNA and irinotecan inhibited the growth of medullary thyroid carcinoma TT cells and xenografts via apoptosis2010
- Author(s)
  K.Koga, Y.Hattori, M.Komori, R.Narishima, M.Yamasaki, M.Hakoshima, T.Fukui, Y.Maitani
- Journal Title
  
  Cancer Science 101
  
  Pages: 941-947
- NAID
  10026590968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Increase of therapeutic effect by treating nasopharyngeal tumor with combination of HER-2 siRNA and paclitaxel2010
- Author(s)
  Y.Hattori, M.Hakoshima, K.Koga, Y.Maitani
- Journal Title
  
  International Journal of Oncology 36
  
  Pages: 1039-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells Euro2009
- Author(s)
  Y. Ishii, Y. Hattori, T. Yamada, S. Uesato, Y. Maitani, Y. Nagaoka
- Journal Title
  
  J. Med. Chem
  
  Volume: 44(11) Pages: 4603-4610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors2009
- Author(s)
  Y.Hattori, L.Shi, W.Ding, K.Koga, K.Kawano, M.Hakoshima, Y.Maitani
- Journal Title
  
  J.Control.Release 136
  
  Pages: 30-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Increase in tumour permeability following TGF-ss type I receptorinhibitor treatment observed by dynamic contrast-enhanced MRI2009
- Author(s)
  T.Minowa, K.Kawano, H.Kuribayashi, K.Shiraishi, T.Sugino, Y.Hattori, M.Yokoyama, Y.Maitani
- Journal Title
  
  British Journal of Cancer 101
  
  Pages: 1884-1890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] The distribution of mRNA expression and protein after hydrodynamic injection of transgene in mice2009
- Author(s)
  Y.Hattori, K.Koga, T.Izumisawa, M.Yamasaki, R.Narishima, S.Yoshida, T.Fukui, Y.Maitani
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 755-759
- NAID
  110007160662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells2009
- Author(s)
  Y.Ishii, Y.Hattori, T.Yamada, S.Uesato, Y.Maitani, Y.Nagaoka
- Journal Title
  
  Euro.J.Med.Chem. 44
  
  Pages: 4603-4610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Higher liposomal membrane fluidity enhances the in vitro anti-tumor acti vity of fblate-targeted liposomal mitoxantrone2009
- Author(s)
  K. Kawano, E. Onose, Y. Hattori, Y. Maitani
- Journal Title
  
  Molecular Phamlaceutics 6(1)
  
  Pages: 98-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] High gene delivery in tumor by intratumoral injection of tetraarginine-PEG liid-coated protamine/DNA2008
- Author(s)
  T. Fujita, M. Furuhata, Y. Hattori, H. Kawakami, K. Toma, Y. Maitani
- Journal Title
  
  J Control Release 129(2)
  
  Pages: 124-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Design of fblate-lhlked liposomal doxorubichl to its antltumor effbct in mlce2008
- Author(s)
  A. Yamada, Y. Taniguchi, K. Kawano, T. Honda, Y. Hattori, Y. Maitani
- Journal Title
  
  CIinical Cancer Res 14(24)
  
  Pages: 8161-8168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Selective delivery of fblate-PEG-linked nanoemulsion-loaded aclachlomycin A to KB nasopharyngeal ceils and xenograft : Effbct of chahl length and amount of fblate-PEG linker2008
- Author(s)
  Y. Ohguchi, K. Kawano, Y. Hattori, Y. Maitani
- Journal Title
  
  J Drug Targeting 16(9)
  
  Pages: 660-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] NaCI improves siRNA delivery mediated by nanoparticle of hydroxyethy lated cationic cholesterol with amido-lhlker2008
- Author(s)
  Y. Hattori, A. Hagiwara, W. Ding and Y. Maitani
- Journal Title
  
  Bioorganic & Medicinal Chemistry letters 18
  
  Pages: 5228-5232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790146
[Journal Article] Low-molecular-weight polyethylenimine enhanced gene transfer by cationic cholesterol-based nanoparticle vector2007
- Author(s)
  Y. Hattori. Y. Maitani
- Journal Title
  
  Bio. Pharm. Bull. 30
  
  Pages: 1773-1778
- NAID
  110006380267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Structure modification of andrographolide to improve its potency as anticancer2007
- Author(s)
  H. Poerwono, Y. Hattori, H, Kubo and K. Higashiyama
- Journal Title
  
  Indo. J. Chem 7
  
  Pages: 202-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] DNA/lipid complex incorporated with fibronectin to cell adhesion enhances transfection efficiency in prostate cancer cells and xenografts2007
- Author(s)
  Y. Hattori and Y. Maitani,
- Journal Title
  
  Bio. Pharm. Bull. 30
  
  Pages: 603-607
- NAID
  110006239214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice2007
- Author(s)
  M.Fukushima, Y.Hattori, T.Yoshizawa, Y.Maitani
- Journal Title
  
  International Journal of Oncology 30
  
  Pages: 225-231
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Cationic liposome (DC-Chol/DOPE=1:2) and a modified ethanol injection method to prepare liposomes, increased gene expression2007
- Author(s)
  Y. Maitani, S. Igarashi, M. Sato, Y. Hattori
- Journal Title
  
  Int J. Pharm. 342
  
  Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Highly efficient cationic hydroxyethylated cholesterol-based nanoparticle-mediatedgene transfer in vivo and in prostate carcinoma PC-3 cells2007
- Author(s)
  Y. Hattori, W. Ding, Y. Maitani
- Journal Title
  
  J Control Release 120
  
  Pages: 122-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection.2007
- Author(s)
  M. Fukushima, Y. Hattori. H. Tsukada, K. Koga, E. Kajiwara, K. Kawano, T. Kobayashi, K. Kamata, Y. Maotamo.
- Journal Title
  
  J Gene Medcine 9
  
  Pages: 976-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Non-viral delivery of connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo tumor growth2007
- Author(s)
  Y. Hattori, M. Fukushima and Y. Maitani.
- Journal Title
  
  Int. J. Oncology 30
  
  Pages: 1427-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Long-circulating liposome-encapsulated ganciclovir enhances the efficacy of herpes simplex virus thymidine kinase suicide gene therapy in mice bearing nasopharyngeal xenografts2007
- Author(s)
  E. Kajiwara, K. Kawano, Y. Hattori, M. Fukushima, K. Hayashi, Y. Maitani
- Journal Title
  
  J Control Release 120
  
  Pages: 104-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Polymeric micelles modified by folate-PEG-lipid for targeted drug delivery to cancer cells in vitro2007
- Author(s)
  A. Hayama, T. Yamamoto, M. Yokoyama, K. Kawano, Y. Hattori, Y. Maitani
- Journal Title
  
  J. Nanoscience and Nanotechnology 8
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Intracellular delivery of proteins in complexes with oligo-arginine modified liposomes, and the effect of oligo-arginine length2006
- Author(s)
  M.Furuhata, H.Kawakami, K.Toma, Y.Hattori, Y.Maitani
- Journal Title
  
  Bioconjugate Chemistry 17(4)
  
  Pages: 935-942
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Folate-linked lipid-based nanoparticles deliver a NFκB decoy into activated murine macrophage-like RAW264.7 cells2006
- Author(s)
  Y.Hattori, M.Sakaguchi, Y.Maitani
- Journal Title
  
  Bio. Pharm. Bull. 29
  
  Pages: 1516-1520
- NAID
  110005602336
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Liposome vector containing biosurfactant-complexed DNA as herpes simplex virus thymidine kinase gene delivery system2006
- Author(s)
  Y.Maitani, S.Yano, Y.Hattori, M.Furuhata, Y.Hayashi
- Journal Title
  
  J. Liposome Res. 16
  
  Pages: 359-372
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin2006
- Author(s)
  Y.Hiruta, Y.Hattori, K.Kawano, Y.Obata, Y.Maitani
- Journal Title
  
  Journal of Controlled Release 113
  
  Pages: 146-154
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Two-step transcriptional amplification-lipid-based nanoparticles using PSMA or midkine promoter for suicide gene therapy in prostate cancer2006
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Cancer Science 97
  
  Pages: 787-798
- NAID
  10018768493
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Biosurfactant MEL-A enhances cellular association and gene transfection by cationic liposome2006
- Author(s)
  S.Igarashi, Y.Hattori, Y.Maitani
- Journal Title
  
  Journal of Controlled Release 112
  
  Pages: 362-368
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Design, synthesis and gene delivery efficiency of novel oligo-arginine linked PEG-lipids : effect of oligo-arginine length2006
- Author(s)
  M.Furuhata, H.Kawakami, K.Toma, Y.Hattori, Y.Maitani
- Journal Title
  
  Int. J. Pharm. 316(1-2)
  
  Pages: 109-116
- NAID
  10014459956
- Data Source
  KAKENHI-PROJECT-18790691
[Journal Article] Ultra-deformable liposomes containing bleomycin : In vitro stability and toxicity on human cutaneous keratinocyte cell lines2005
- Author(s)
  K.G.Lau, Y.Hattori, S.Chopra, E.A.O'Toole, A.Storey, T.Nagai, Y.Maitani
- Journal Title
  
  Int.J.Pharm 300
  
  Pages: 4-12
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked lipid-based nanoparticle for targeted gene delivery2005
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Current Drug Delivery in press
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase2005
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Cancer Gene Therapy 12
  
  Pages: 796-809
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked nanoparticles formed with DNA complexes in sodium chloride solution enhance transfection efficiency2005
- Author(s)
  Y.Hattori, H.Kubo, K.Higashiyama, Y.Maitani
- Journal Title
  
  J.Biomedical Nanotechnology 1
  
  Pages: 176-184
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked lipid-based nanoparticles for tumor-targeted gene therapy2005
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Nanotechnologies for the Life Science (edited by C.Kumar)(Wiley-VCH) 1
  
  Pages: 270-298
- NAID
  10016886959
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Effect of the Polyethylene Glycol linker Chain Length of Folate-linked Microemulsions Loading Aclacinomycin A on Targeting Ability and Antitumor Effect in vitro and in vivo2005
- Author(s)
  T.Shiokawa, Y.Hattori, K.Kawano, Y.Ohguchi, H.Kawakami, K.Toma, Y.Maitani
- Journal Title
  
  Clinical Cancer Research in press
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase2005
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Cancer Gene Therapy in press
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Folate-linked lipid-based nanoparticle for targeted gene delivery2005
- Author(s)
  Y.Hattori, Y.Maitani
- Journal Title
  
  Current Drug Delivery 2
  
  Pages: 243-252
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Enhanced in vitro DNA transfection efficiency by novel folate-linked nanoparticles in human prostate cancer and oral cancer2004
- Author(s)
  Y.Hattori, Y.Maitani.
- Journal Title
  
  Journal of Controlled Release 97
  
  Pages: 173-184
- Data Source
  KAKENHI-PROJECT-16790113
[Journal Article] Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery2004
- Author(s)
  T.Nagamoto, Y.Hattori, K.Takayama, Y.Maitani.
- Journal Title
  
  Pharmaceutical Research 21
  
  Pages: 671-674
- Data Source
  KAKENHI-PROJECT-16790113
[Patent] 遺伝子発現増強剤およびそれを用いた遺伝子発現増強方法2008
- Inventor(s)
  長岡康夫、服部喜之、上里新一、米谷芳江
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2008-189946
- Filing Date
  2008-07-23
- Data Source
  KAKENHI-PROJECT-19590110
[Patent] 特許2008
- Inventor(s)
  長岡康夫, 服部喜之, 上里新一, 米谷芳枝
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2008-189946
- Filing Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-19590110
[Patent] オリゴアルギニン脂質2004
- Inventor(s)
  川上宏子, 戸間一孔, 古幡昌彦,服部喜之, 米谷芳枝
- Industrial Property Rights Holder
  財団法人野口研究所
- Filing Date
  2004-08-17
- Data Source
  KAKENHI-PROJECT-16790113
[Patent] 核酸医薬を標的特異的に送達するための製剤2004
- Inventor(s)
  服部喜之, 米谷芳枝, 脇厚生, 坂口誠, 山田英
- Industrial Property Rights Holder
  アンジェスMG株式会社
- Filing Date
  2004-10-15
- Data Source
  KAKENHI-PROJECT-16790113
[Presentation] 葉酸修飾siRNAリポプレックスのPEG修飾に用いるPEG誘導体のアンカー部が及ぼすマウス生体内分布および抗腫瘍効果の影響2022
- Author(s)
  唐敏、逆井勝、大西啓、川野久美、服部喜之
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07142
[Presentation] 葉酸修飾siRNAリポプレックスのPEG修飾に用いるPEG誘導体のアンカー部が及ぼす遺伝子発現抑制効果とマウス生体内分布への影響2022
- Author(s)
  唐敏，逆井勝，大西啓，川野久美，服部喜之
- Organizer
  日本薬学会　第142年会
- Data Source
  KAKENHI-PROJECT-20K07142
[Presentation] PEG化コンドロイチン硫酸を用いたsiRNAリポプレックスのPEG修飾が及ぼす遺伝子発現抑制効果とマウス生体内分布の影響2021
- Author(s)
  服部喜之、逆井勝、唐敏、大西啓
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K07142
[Presentation] がん細胞へのsiRNA導入に及ぼす葉酸修飾リポプレックスのPEG修飾の影響2021
- Author(s)
  唐敏、逆井勝、大西啓、服部喜之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K07142
[Presentation] PEG修飾siRNAリポプレックスのPEGアンカー部の違いが及ぼすin vitro遺伝子発現抑制効果とマウス生体内分布の影響2020
- Author(s)
  服部喜之、玉置響子、逆井勝、尾﨑恵一、大西啓
- Organizer
  日本薬剤学会　第35年会
- Data Source
  KAKENHI-PROJECT-20K07142
[Presentation] siRNA送達用正電荷リポソーム製剤に用いる正電荷脂質と中性脂質の最適化2019
- Author(s)
  岸本準，大西啓，服部喜之
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸とPLK1またはHSF1 siRNAリポプレックスの連続投与による肝転移がん治療2018
- Author(s)
  服部喜之，菊地拓人，尾﨑惠一，大西啓
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸とsiRNAリポプレックスの連続投与におけるsiRNAの生体内分布と遺伝子発現抑制効果に及ぼす正電荷リポソームの正電荷脂質の影響2018
- Author(s)
  服部喜之，中村麻里，竹内のぞみ，吉池悠貴，田口将光，大野浩章，尾﨑惠一，大西啓
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸とsiRNAリポプレックス連続投与における正電荷リポソームの正電荷脂質の違いによるsiRNAの生体内分布への影響2017
- Author(s)
  中村麻里，服部喜之，設楽亮介，御園宥江，大西啓
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸とsiRNAリポプレックス連続投与後のマウス肝臓におけるsiRNAの集積性の検討2017
- Author(s)
  服部喜之，花屋志織，宮鍋侑大，中村文子，尾﨑惠一，大西啓
- Organizer
  第17回遺伝子・デリバリー研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] 正電荷コレステロール誘導体を用いて調製したリポソーム製剤による肝臓へのsiRNA送達2017
- Author(s)
  竹内のぞみ，服部喜之，五十嵐康晃，梅木優子，大西啓
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸被覆siRNAリポプレックス投与とコンドロイチン硫酸とsiRNAリポプレックス連続投与による肝臓へのsiRNA送達性の比較2017
- Author(s)
  服部喜之，吉池悠貴，大西啓
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] 正電荷リポソームの正電荷脂質の違いによるsiRNAの遺伝子発現抑制効果およびマウス静注後のsiRNAの生体内分布への影響2017
- Author(s)
  服部喜之，竹内のぞみ，中村麻里，大西啓
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08251
[Presentation] コンドロイチン硫酸とsiRNAリポプレックスの連続投与におけるコンドロイチン硫酸が及ぼすsiRNAの生体内分布への影響2017
- Author(s)
  服部喜之，花屋志織，吉池悠貴，菊地拓人，大西啓
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 小角X線散乱測定による正電荷リポソームとsiRNAのリポプレックス形成過程の検討2016
- Author(s)
  米持悦生、木村高暢、Andang Miatmoko、菊池拓人、川野久美、服部喜之、郡司美穂子、古石誉之、遠藤朋宏
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460048
[Presentation] 負電荷ポリマーとsiRNAリポプレックス連続投与による肝臓へのsiRNA送達における負電荷ポリマーの種類と投与法の検討2016
- Author(s)
  菊地拓人，服部喜之，吉池悠貴，山本菜摘，尾﨑惠一，大西啓
- Organizer
  日本薬剤学会　第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] Development of siRNA delivery system to liver metastasis for therapeutic application2016
- Author(s)
  Yoshiyuki Hattori
- Organizer
  The 2016 Mogan Mountain International Summit on Green Pharmaceuticals
- Place of Presentation
  中国・浙江省・杭州市
- Year and Date
  2016-11-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] PKN3 siRNAリポプレックスとドキソルビシンの併用療法による肝ならびに肺転移乳がんに対する抗腫瘍効果の検討2016
- Author(s)
  菊地拓人，服部喜之，中村麻里，尾﨑惠一，大西啓
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] PKN3 siRNAリポプレックスとドキソルビシンの併用療法による肺転移がんに対する治療効果2016
- Author(s)
  中村麻里，服部喜之，菊地拓人，大西啓
- Organizer
  遺伝子・デリバリー研究会　第16回シンポジウム
- Place of Presentation
  神奈川
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] コンドロイチン硫酸とsiRNAリポプレックスの連続投与後のsiRNAの生体内分布に及ぼすコンドロイチン硫酸の投与方法の検討2016
- Author(s)
  吉池悠貴,　服部喜之,　菊地拓人,　大西啓
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] コンドロイチン硫酸とsiRNAリポプレックスの連続投与による肝臓へのsiRNAの導入における投与法の検討2016
- Author(s)
  吉池悠貴，服部喜之，菊地拓人，大西啓
- Organizer
  遺伝子・デリバリー研究会　第16回シンポジウム
- Place of Presentation
  神奈川
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] PKN3 siRNAリポプレックスとドキソルビシンの併用療法による肝転移乳がんに対する抗腫瘍効果の検討2016
- Author(s)
  服部喜之，菊地拓人，大西啓
- Organizer
  遺伝子・デリバリー研究会　第16回シンポジウム
- Place of Presentation
  神奈川
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] コンドロイチン硫酸とsiRNAリポプレックスの連続投与とドキソルビシンの併用療法による肝転移がんに対する抗腫瘍効果の検討2016
- Author(s)
  菊地拓人,　服部喜之, 大西啓
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] ポリグルタミン酸と正電荷リポプレックスの連続投与による肝臓へのsiRNA送達2015
- Author(s)
  菊地拓人，服部喜之，新井翔平，町田曜子，濱田めぐみ，岡本遼，川野久美，米持悦生
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 負電荷ポリマーとsiRNAリポプレックスの連続投与による肝転移がんに対する抗腫瘍効果と安全性評価2015
- Author(s)
  服部喜之，新井翔平，川野久美
- Organizer
  遺伝子・デリバリー研究会　第15回シンポジウム
- Place of Presentation
  京都
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 腫瘍関連マクロファージを標的としたゾレドロン酸封入葉酸修飾リポソーム製剤による抗腫瘍効果の評価2014
- Author(s)
  山下潤，坂井田知里，川野久美，服部喜之，米持悦生
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 腫瘍関連マクロファージを標的としたゾレドロン酸封入葉酸修飾リポソーム製剤による抗腫瘍効果の評価2014
- Author(s)
  山下潤,坂井田知里,川野久美,服部喜之,米持悦生
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 固形がんにおける葉酸受容体の発現と腫瘍関連マクロファージ標的ゾレドロン酸封入葉酸修飾リポソーム製剤の開発2013
- Author(s)
  山下　潤、坂井田　知里、服部　喜之、米谷　芳枝
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 副腎腫瘍発症遺伝子改変マウスにおけるドキソルビシン封入リポソームの治療効果2013
- Author(s)
  川野　久美、服部　喜之、岩倉　浩、赤水　尚史、米谷　芳枝
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 安全性の高いsiRNA導入用負電荷ポリマー被覆リポプレックス製剤の開発2013
- Author(s)
  中村文子,服部喜之,西垣磨優,大倉博之,山作晴香,米谷芳枝
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 新規正電荷コレステロール誘導体を用いて調製した脂質ナノ粒子製剤によるがん細胞へのsiRNA送達2013
- Author(s)
  服部喜之,中村司,大野浩章,藤井信孝,米谷芳枝
- Organizer
  第13回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-05-11
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 固形がんにおける葉酸受容体の発現と腫瘍関連マクロファージ標的ゾレドロン酸封入葉酸修飾リポソーム製剤の開発2013
- Author(s)
  山下潤,坂井田知里,服部喜之,米谷芳枝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 甲状腺乳頭癌における葉酸受容体発現,金本巨哲2012
- Author(s)
  服部喜之,上田依利子,曽根正勝,三浦晶子,八十田明宏,荒井宏司,米谷芳枝,中尾一和
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 脂質ナノ粒子製剤を用いたがんへの遺伝子送達2012
- Author(s)
  服部喜之
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 第8回つくばがん遺伝子治療研究会2012
- Author(s)
  服部喜之
- Organizer
  がん遺伝子治療のための非ウイルスベクターの開発
- Place of Presentation
  東京
- Year and Date
  2012-07-12
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] アンギオテンシンII昇圧下におけるリポプレックスの腫瘍内分布2011
- Author(s)
  田中拓海, 服部喜之, 米谷芳枝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] アンギオテンシンII昇圧下におけるリポプレックスの腫瘍内分布2011
- Author(s)
  田中拓海, 服部喜之, 米谷芳枝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] リポフェクション効率向上効果を有するプロドラッグ化ヒストン脱アセチル化酵素阻害剤2011
- Author(s)
  置田裕子、中野宏樹、吉田耕平、吉野宏美、上里新一、服部喜之、米谷芳枝、長岡康夫
- Organizer
  日本薬学会131年会
- Place of Presentation
  グランシップツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] 類型の異なるヒストン脱アセチル化酵素阻害剤がリポフェクション効率におよぼす影響2011
- Author(s)
  吉野宏美、置田裕子、中野宏樹、服部喜之、米谷芳枝、上里新一、長岡康夫
- Organizer
  日本薬学会131年会
- Place of Presentation
  グランシップツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] がん遺伝子導入用負電荷ポリマー被覆リポプレックス製剤の開発2011
- Author(s)
  山作晴香,服部喜之,米谷芳枝
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] コラゲナーゼ処理した担がんマウスにおけるリポプレックスの腫瘍集積性及び遺伝子発現2011
- Author(s)
  服部喜之，加藤真子，久保愛美，米谷芳枝
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2011
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] 副腎腫瘍自然発症遺伝子改変マウスのDNAマイクロアレイによる遺伝子解析2010
- Author(s)
  服部喜之, 金本巨哲, 川野久美, 岩倉浩, 赤水尚史, 中尾一和, 米谷芳枝
- Organizer
  第83回日本内分泌学会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] Prodrugs of Histone Deacetylase Inhibitor K-182 Enhanced Expression of Genes Transfected with Cationic Cholesterol-Based Nanoparticle Vector2010
- Author(s)
  H. Okita, Y. Ishii, S. Uesato, Y. Hattori, Y. Maitani, Y. Nagaoka
- Organizer
  11th Tetrahedron Symposium
- Place of Presentation
  北京大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] アンギオテンシンIIによる昇圧下でのリポソーム製剤の腫瘍集積性の検討2010
- Author(s)
  生形晴哉, 服部喜之, 米谷芳枝
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] 新規遺伝子発現増強剤DDTS-K-1822010
- Author(s)
  中野宏樹、置田裕子、石井佑太、長岡康夫、上里新一、服部喜之、米谷芳枝
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] アンギオテンシンII昇圧下における正電荷リポソームの癌遺伝子送達2010
- Author(s)
  田中拓海, 服部喜之, 米谷芳枝
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] Prodrugs of Histone Deacetylase Inhibitor K-182 Enhanced Expression of Genes Transfected with Cationic Cholesterol-Based Nanoparticle Vector2010
- Author(s)
  H.Okita, Y.Ishii, S.Uesato, Y.Hattori, Y.Maitani, Y.Nagaoka
- Organizer
  11th Tetrahedron Symposium
- Place of Presentation
  北京大学(中国)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] アンギオテンシンII昇圧下における正電荷リポソームのがん遺伝子送達2010
- Author(s)
  田中拓海, 服部喜之, 米谷芳枝
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] 副腎腫瘍発症遺伝子改変マウスのMRIによる腫瘍増殖評価2009
- Author(s)
  川野久美, 服部喜之, 横山昌幸, 岩倉浩, 赤水尚史, 米谷芳枝
- Organizer
  第4回日本分子イメージング学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] ハイドロダイナミクス'により遺伝子導入したマウスにおけるmRNA発現体内分布と発現タンパク質活性2009
- Author(s)
  服部暑之、回公子、泉澤友宏、山崎正博、成島遼太、福井哲也、米谷芳枝
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] アンギオテンシンIIを用いた昇圧療法によるドキソルビシン封入リボソーム製剤の担がんマウスの体内分布の評価2009
- Author(s)
  生形晴哉, 服部喜之, 米谷芳枝
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] 非ウイルスベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発2009
- Author(s)
  石井佑太、山田敏晴、濱本和隆、田中菜津子、上里新一、長岡康夫、服部喜之、米谷芳枝
- Organizer
  日本薬学会第129年会要旨集4 P.215
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] Molecular characterizations of tumors from human pheochromocytoma and adrenal neuroblastoma-model transgenic mice2009
- Author(s)
  服部喜之, 金本巨哲, 川野久美, 岩倉浩, 赤水尚史, 中尾一和, 米谷芳枝
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] アンギオテンシンIIを用いた昇圧療法によるドキソルビシン封入リポソーム製剤の担がんマウスの体内分布の評価2009
- Author(s)
  生形晴哉, 服部喜之, 米谷芳枝
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] 正電荷ナノ粒子ベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラツグの開発2008
- Author(s)
  長岡康夫, 山田敏晴, 石井佑太, 濱本和隆, 田中菜津子, 上里新一, 服部喜之, 米谷芳枝
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪(メルパルク大阪)
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] Cationic Hydroxyethylated Cholesterol-based Nanoparticle-Mediated Synthetic siRNA Transfer into Prostate Carcinoma PC-3 Cells2008
- Author(s)
  Y. Hattori and Y. Maitani
- Organizer
  11th LIPOSOME RESEARCH DAYS CONFERENCE
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790146
[Presentation] 正電荷ナノ粒子ベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発2008
- Author(s)
  長岡康夫、山田敏晴、石井佑太、濱本和隆、田中菜津子、上里新一、服部喜之、米谷芳枝
- Organizer
  第27回メディシナルケミストリーシンポジウム要旨集p.330-332
- Place of Presentation
  メルパルク大阪
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] 正電荷コレステロールナノ粒子によるplasmid DNAと短鎖2本鎖RNAの前立腺癌への遺伝子導入2007
- Author(s)
  服部喜之、米谷芳枝
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18790691
[Presentation] 正電荷コレステロールナノ粒子を用いた前立腺癌への遺伝子導入2007
- Author(s)
  服部喜之、丁武孝、米谷芳枝
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-18790691
[Presentation] ヒト扁平上皮癌に対するコネキシン43遺伝子とヒストン脱アセチル化酵素阻害剤の併用治療2007
- Author(s)
  服部喜之、米谷芳枝
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18790691
[Presentation] 負電荷ポリマーと正電荷リポプレックスの連続投与による肝臓へのsiRNA送達における負電荷ポリマーの種類と正電荷リポプレックスの荷電比の最適化
- Author(s)
  岡本遼，服部喜之，新井翔平，濱田めぐみ，川野久美，米持悦生
- Organizer
  第30回日本ＤＤＳ学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460048
[Presentation] コンドロイチン硫酸と正電荷リポプレックスの連続投与による肝臓ならびに肝臓転移がんに対するsiRNA送達
- Author(s)
  新井翔平，服部喜之，川野久美，米持悦生
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] ポリグルタミン酸と正電荷リポプレックスの連続投与は肝臓ならびに肝臓転移がんに対してsiRNAによる遺伝子発現抑制を誘導する
- Author(s)
  新井翔平、服部喜之、岡本遼、濱田めぐみ、川野久美、米持悦生
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 肝臓へsiRNAを送達するための負電荷ポリマー溶液と正電荷リポプレックスの連続投与法の開発
- Author(s)
  新井翔平，服部喜之，岡本遼，濱田めぐみ，川野久美，米持悦生
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26460048
[Presentation] 肝臓へsiRNAを送達するための負電荷ポリマー溶液と正電荷リポプレックスの連続投与法の開発
- Author(s)
  新井翔平、服部喜之、岡本遼、濱田めぐみ、川野久美、米持悦生
- Organizer
  日本薬剤学会　第29年会
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] PEG化ヒストン脱アセチル化酵素阻害剤の抗がん活性
- Author(s)
  上條洋士、木村元気、服部善之、住吉孝明、上里新一、長岡康夫
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学他（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590152
[Presentation] 負電荷ポリマーと正電荷リポプレックスの連続投与による肝臓へのsiRNA送達における負電荷ポリマーの種類と正電荷リポプレックスの荷電比の最適化
- Author(s)
  岡本遼、服部喜之、新井翔平、濱田めぐみ、川野久美、米持悦生
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] ポリグルタミン酸と正電荷リポプレックスの連続投与は肝臓ならびに肝臓転移がんに対してsiRNAによる遺伝子発現抑制を誘導する
- Author(s)
  新井翔平，服部喜之，岡本遼，濱田めぐみ，川野久美，米持悦生
- Organizer
  第30回日本ＤＤＳ学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460048
[Presentation] 負電荷ポリマー被覆リポプレックスによる肝臓へのsiRNA送達
- Author(s)
  服部喜之、西垣磨優、大倉博之、中村文子、新井翔平、川野久美、米持悦生
- Organizer
  日本薬剤学会　第29年会
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 負電荷ポリマーとsiRNAリポプレックスの連続投与による肝転移がんに対する遺伝子発現抑制効果と抗腫瘍効果
- Author(s)
  服部喜之，新井翔平，川野久美，米持悦生
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460046
[Presentation] 新規正電荷コレステロール誘導体を用いて調製した脂質ナノ粒子製剤によるがん細胞へのsiRNA送達
- Author(s)
  服部喜之，中村司，大野浩章，藤井信孝，米谷芳枝
- Organizer
  第13回　遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] siRNA送達用肝臓標的ナノ粒子製剤の開発
- Author(s)
  新井翔平，服部喜之，米持悦生
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790203
[Presentation] Sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA could effectively deliver siRNA to the liver
- Author(s)
  Y. Hattori, S. Arai, R. Okamoto, M. Hamada, K. Kawano and E. Yonemochi
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  デンマーク，コッペンハーゲン
- Year and Date
  2014-08-04 – 2014-08-07
- Data Source
  KAKENHI-PROJECT-26460046

1. NAGAOKA Yasuo (90243039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. UESATO Shinichi (50111969)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. Yonemochi Etsuo (40201090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. KAWANO Kumi (20366834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 尾崎恵一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 米谷芳枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 築地信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HATTORI Yoshiyuki 服部 喜之

Research Projects

Research Products

Co-Researchers

Development of mRNA lipid nanoparticles for tumor vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of folate-modified siRNA lipoplexes for tumor-targeting by intravenous injectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of siRNA therapy for liver-metastasized tumor by sequential intravenous injection of chondroitin sulfate and siRNA lipoplexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

siRNA delivery to tumor by sequential injection of anionic polymer and siRNA lipoplexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on solid formulation of lipoplex using ionic liquid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effect

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of antitumor effect of tumor-associated macrophage-targeting liposomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Angiotensin II-induced hypertension enhanced delivery of liposomal anti-cancer drugs into tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

デコイ核酸による炎症性疾患治療用炎症標的遺伝子ベクターの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

前立腺癌標的自殺遺伝子治療のための葉酸修飾脂質微粒子ベクターシステムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of PEG anchor in PEGylation of folate-modified cationic liposomes with PEG-derivatives on systemic siRNA delivery into the Tumor2023

Author(s)

Journal Title

DOI

HATTORI Yoshiyuki 服部喜之