TAKASUGA Shunsuke 高須賀俊輔

Researcher Number	90375262
Other IDs
Affiliation (Current)	2025: 秋田大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 秋田大学, 医学系研究科, 助教 2012 – 2016: 秋田大学, 医学(系)研究科(研究院), 助教 2009 – 2011: Akita University, 大学院・医学系研究科, 助教 2008: 東北大学, 医学部, 助教 2007 – 2008: Akita University, 医学部, 助教 2005 – 2006: 秋田大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General medical chemistry Except Principal Investigator Biological Sciences / Biological pharmacy / Basic Section 49030:Experimental pathology-related / General medical chemistry / Emergency medicine / General pharmacology
Keywords	Principal Investigator リン脂質 / イノシトールリン脂質 / ミトコンドリア / 脂質 / 遺伝子改変マウス / Inpp4b / Pten / カルジオリピン / ホスホイノシタイド / PTEN … More / がん抑制遺伝子 / INPP4B / 細胞内シグナル伝達 / 糖尿病 / 脳神経疾患 / 発生・分化 / 細胞生物学 / 臓性内胚葉 … More Except Principal Investigator イノシトールリン脂質 / リン脂質 / 脂質 / シグナル伝達 / mRNA代謝 / 自然リンパ球 / 病態モデルマウス / がん / 病態モデル / 細胞膜 / 急性呼吸不全 / インフルエンザ / 細胞膜イノシトールリン脂質 / ウイルス感染症 / 呼吸不全 / 集中治療 / 神経科学 / 脳神経疾患 / ３型免疫 / ２型免疫 / １型免疫 / 転写後調節 / ILC3 / ILC2 / ILC1 / NK細胞 / 転写後制御 / ホスファターゼ / キナーゼ / 質量分析 / 疾患モデル / 長寿 / 細胞・組織 / 分子病態学 / 細胞増殖 / 発癌 / 前立腺 / 細胞内小胞輸送 / 臓性内胚葉 / 遺伝子改変マウス Less

免疫体質を規定するRNA代謝ネットワークの解析
- Principal Investigator
  
  海老原敬
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Akita University
INPP4BによるPTEN機能代替の分子機構の解析Principal Investigator
- Principal Investigator
  
  高須賀俊輔
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Akita University
mRNA metabolism specific to ILC subsets
- Principal Investigator
  
  Ebihara Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Akita University
ミトコンドリア脂質代謝異常に起因する転写活性制御機構の解明Principal Investigator
- Principal Investigator
  
  高須賀俊輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Akita University
Elucidation of the mechanism of anticancer activity of the cancer suppressor gene INPP4BPrincipal Investigator
- Principal Investigator
  
  TAKASUGA Shunsuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Akita University
Metabolism and functions of novel phospholipids
- Principal Investigator
  
  Sasaki Takehiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical and Dental University
  Akita University
Metabolism and functions of novel phospholipids
- Principal Investigator
  
  Sasaki Takehiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
Physiological function of phosphatidylinositol 3,5-bisphosphate in oligodendrocytesPrincipal Investigator
- Principal Investigator
  
  Takasuga Shunsuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
Identification of phosphatidylglycerophosphate-binding proteins.Principal Investigator
- Principal Investigator
  
  TAKASUGA SHUNSUKE
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by PhosphoinositidesPrincipal Investigator
- Principal Investigator
  
  TAKASUGA Shunsuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
Establishment of a new paradigm in the phosphoinositide research
- Principal Investigator
  
  SASAKI Junko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
脂質脱リン酸化酵素阻害によるリソソーム機能賦活・長寿モデルマウスの開発
- Principal Investigator
  
  佐々木雄彦
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
細胞増殖・死の制御と癌の悪性化におけるクラスIIIPI3キナーゼの役割
- Principal Investigator
  
  佐々木雄彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University
Role of phospholipids in the pathogenesis of respiratory failure mediated by highly pathogenic influenza virus infection
- Principal Investigator
  
  IMAI Yumiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  General pharmacology
- Research Institution
  Akita University
Role of phosphatidylinositols in the pathogenesis of severe respiratory failure
- Principal Investigator
  
  IMAI Yumiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Akita University
Physiological Function of PI 3-phosphate 5-kinasePrincipal Investigator
- Principal Investigator
  
  TAKASUGA Shunsuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
新規リン脂質代謝酵素欠損マウスでの著明な小胞輸送異常と病態
- Principal Investigator
  
  佐々木雄彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University
ホスファチジルイノシトール3リン酸5ーキナーゼの機能解析Principal Investigator
- Principal Investigator
  
  高須賀俊輔
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
脂質代謝異常による不随意運動の発現メカニズム
- Principal Investigator
  
  SASAKI Takehiko
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University
イノシトールリン脂質代謝異常に起因する運動異常モデルマウスの解析
- Principal Investigator
  
  佐々木純子
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University

[Book] 実験医学増刊　イノシトールリン脂質におけるリン酸化クオリティ制御の病態生理学的意義2019
- Author(s)
  高須賀俊輔、佐々木雄彦
- Total Pages
  246
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17H03980
[Book] 脂質クオリティ2018
- Author(s)
  高須賀俊輔・佐々木雄彦（編集＝有田誠）
- Total Pages
  220
- Publisher
  羊土社
- ISBN
  9784758103718
- Data Source
  KAKENHI-PROJECT-18K06623
[Book] 疾患モデルの作製と利用ー脂質代謝異常と関連疾患《下巻》2015
- Author(s)
  高須賀俊輔、佐々木雄彦
- Total Pages
  413
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-26460059
[Journal Article] TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy2023
- Author(s)
  Yamada T, Tatematsu M, Takasuga S, Fuchimukai A, Yamagata K, Seki S, Kuba K, Yoshida H, Taniuchi I, Bernhardt G, Shibuya K, Shibuya A, Yamada T, Ebihara T.
- Journal Title
  
  J Exp Med
  
  Volume: 220 Issue: 7 Pages: 20222005-20222005
- DOI
  10.1084/jem.20222005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06542, KAKENHI-PROJECT-20H03832, KAKENHI-PROJECT-23K08954, KAKENHI-PROJECT-21K19368, KAKENHI-PROJECT-22K19551, KAKENHI-PLANNED-19H05747
[Journal Article] 2型自然リンパ球の訓練免疫2022
- Author(s)
  海老原敬, 立松恵, 高須賀俊輔, 山田俊樹, 山田武千代
- Journal Title
  
  【COPDと気管支喘息、その周辺疾患-病態・診断・治療の最新動向-】喘息病態up-to-date
  
  Volume: 80 Pages: 586-590
- Data Source
  KAKENHI-PROJECT-21H02707
[Journal Article] Trained innate lymphoid cells in allergic diseases2021
- Author(s)
  Ebihara T, Tatematsu M, Fuchimukai A, Yamada T, Yamagata K, Takasuga S, Yamada T
- Journal Title
  
  Allergol. Int.
  
  Volume: 70 Issue: 2 Pages: 174-180
- DOI
  10.1016/j.alit.2020.11.007
- NAID
  130008024334
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02647, KAKENHI-PROJECT-17K11356, KAKENHI-PROJECT-18K06623, KAKENHI-PROJECT-21H02707, KAKENHI-PROJECT-21K06542, KAKENHI-PROJECT-21K19368, KAKENHI-PROJECT-20H03832
[Journal Article] PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel.2019
- Author(s)
  Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K.
- Journal Title
  
  J Biochem.
  
  Volume: 165 Issue: 1 Pages: 75-84
- DOI
  10.1093/jb/mvy084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06623
[Journal Article] Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning.2019
- Author(s)
  Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K.
- Journal Title
  
  J Biochem.
  
  Volume: 166 Issue: 2 Pages: 175-185
- DOI
  10.1093/jb/mvz026
- NAID
  40021974923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06623
[Journal Article] Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages2019
- Author(s)
  Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 6 Pages: 923-928
- DOI
  10.1248/bpb.b18-00907
- NAID
  130007657676
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06623
[Journal Article] Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression2019
- Author(s)
  Koizumi Atsushi、Narita Shintaro、Nakanishi Hiroki、Ishikawa Masaki、Eguchi Satoshi、Kimura Hirotaka、Takasuga Shunsuke、Huang Mingguo、Inoue Takamitsu、Sasaki Junko、Yoshioka Toshiaki、Habuchi Tomonori、Sasaki Takehiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13257-13257
- DOI
  10.1038/s41598-019-49744-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-18K06623, KAKENHI-PROJECT-18K06981, KAKENHI-PROJECT-19K09663, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-18H04877, KAKENHI-PROJECT-16H02679, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22508, KAKENHI-PLANNED-15H05899
[Journal Article] Lysophosphatidylinositol‐acyltransferase‐1 is involved in cytosolic Ca2+ oscillations in macrophages2019
- Author(s)
  Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、Hazeki Kaoru
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 5 Pages: 1-11
- DOI
  10.1111/gtc.12681
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-18K07233, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-18H04877, KAKENHI-PROJECT-17K19375, KAKENHI-PROJECT-18K06623, KAKENHI-PROJECT-17H03980, KAKENHI-PROJECT-19K22508, KAKENHI-PLANNED-15H05899
[Journal Article] PIKfyve regulates melanosome biogenesis2018
- Author(s)
  Liggins Marc C.、Flesher Jessica L.、Jahid Sohail、Vasudeva Priya、Eby Victoria、Takasuga Shunsuke、Sasaki Junko、Sasaki Takehiko、Boissy Raymond E.、Ganesan Anand K.
- Journal Title
  
  PLOS Genetics
  
  Volume: 14 Issue: 3 Pages: e1007290-e1007290
- DOI
  10.1371/journal.pgen.1007290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06623, KAKENHI-ORGANIZER-15H05897, KAKENHI-PUBLICLY-18H04877, KAKENHI-PROJECT-17K19375, KAKENHI-PROJECT-17H03980, KAKENHI-PLANNED-15H05899
[Journal Article] TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis2018
- Author(s)
  Morioka Shin、Nigorikawa Kiyomi、Okada Eri、Tanaka Yoshimasa、Kasuu Yoshihiro、Yamada Miho、Kofuji Satoshi、Takasuga Shunsuke、Nakanishi Hiroki、Sasaki Takehiko、Hazeki Kaoru
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Issue: 5 Pages: 213272-213272
- DOI
  10.1242/jcs.213272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04693, KAKENHI-PROJECT-18K06623, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-17H03980, KAKENHI-PLANNED-15H05899
[Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.2017
- Author(s)
  Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 1 Pages: 89462-89478
- DOI
  10.1172/jci.insight.89462
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05978, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26253083, KAKENHI-PROJECT-15H04693, KAKENHI-PROJECT-26293050, KAKENHI-PROJECT-26460059, KAKENHI-PROJECT-26461458, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-15K15304, KAKENHI-PLANNED-25111005, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26670132, KAKENHI-PROJECT-15K18857, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-26640081, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-17H03980
[Journal Article] The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis2017
- Author(s)
  Kimura Hirotaka、Matsuyama Yasushi、Araki Sachiko、Koizumi Atsushi、Kariya Yumi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Sasaki Junko、Sasaki Takehiko
- Journal Title
  
  Modern Rheumatology
  
  Volume: 28 Issue: 3 Pages: 530-541
- DOI
  10.1080/14397595.2017.1367116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19375, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-15H04693, KAKENHI-PROJECT-18K06623, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-17H03980, KAKENHI-PLANNED-15H05899
[Journal Article] The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells.2015
- Author(s)
  Hammond GR, Takasuga S, Sasaki T, Balla T.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0139957-e0139957
- DOI
  10.1371/journal.pone.0139957
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460059, KAKENHI-PROJECT-15K14947, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-26253006
[Journal Article] INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.2015
- Author(s)
  Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T.
- Journal Title
  
  Cancer Discov.
  
  Volume: 5 Pages: 365-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460059
[Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor.2015
- Author(s)
  Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
- Journal Title
  
  Cancer Discovery
  
  Volume: in press Issue: 7 Pages: 730-9
- DOI
  10.1158/2159-8290.cd-14-1329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26461458, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-15K18857, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-26860686, KAKENHI-PROJECT-25293332
[Journal Article] Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20.2014
- Author(s)
  Segawa T, Hazeki K, Nigorikawa K, Morioka S, Guo Y, Takasuga S, Asanuma K, Hazeki O.
- Journal Title
  
  Biochem. J.
  
  Volume: 464 Issue: 3 Pages: 365-375
- DOI
  10.1042/bj20140916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460059
[Journal Article] Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions.2013
- Author(s)
  Takasuga S. and Sasaki T.
- Journal Title
  
  J. Biochem.
  
  Volume: 154 Issue: 3 Pages: 211-218
- DOI
  10.1093/jb/mvt064
- NAID
  40019769805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659124
[Journal Article] Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos2012
- Author(s)
  Kawamura, Wada et al.
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1071-1071
- DOI
  10.1038/ncomms2069
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-21390050, KAKENHI-PROJECT-23570178, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24659124, KAKENHI-PUBLICLY-23113716
[Journal Article] 3'phosphatase activity toward PI (3,4) P2 by voltage-sensing phosphatase, VSP.2012
- Author(s)
  Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22790055
[Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012
- Author(s)
  Hazeki K.
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Issue: 22 Pages: 4010-4015
- DOI
  10.1016/j.febslet.2012.09.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-24659124
[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2012
- Author(s)
  Takasuga , Wada et al.
- Journal Title
  
  PNAS 110
  
  Volume: 1726-1731 Issue: 5 Pages: 1726-31
- DOI
  10.1073/pnas.1213212110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-21390050, KAKENHI-PROJECT-23229001, KAKENHI-PROJECT-23701036, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24590930, KAKENHI-PROJECT-24657081, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24659124, KAKENHI-PROJECT-24770115, KAKENHI-PROJECT-24790734, KAKENHI-PUBLICLY-25113517, KAKENHI-PROJECT-25650066, KAKENHI-PUBLICLY-23113706, KAKENHI-PUBLICLY-23113716, KAKENHI-PUBLICLY-23121505, KAKENHI-PUBLICLY-24112515
[Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011
- Author(s)
  Hazeki, K., Kametani, Y., et al, (11名中7番目)
- Journal Title
  
  PLoS One.
  
  Volume: 6 Issue: 10 Pages: e26836-e26836
- DOI
  10.1371/journal.pone.0026836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21200079, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-22790055, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] The PI(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic Neuronal Death2010
- Author(s)
  Sasaki, J., Kofuji, S., et al(20名中1番目, 2番目, 9番目, 10番目)
- Journal Title
  
  Nature
  
  Volume: 465 Issue: 7297 Pages: 497-501
- DOI
  10.1038/nature09023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21500374, KAKENHI-PROJECT-22790055
[Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion2010
- Author(s)
  Hiramine Y, Emoto H, Takasuga S, Hiramatsu R
- Journal Title
  
  J.Lipid Res
  
  Volume: 51 Issue: 6 Pages: 1424-1431
- DOI
  10.1194/jlr.m002584
- Data Source
  KAKENHI-PROJECT-22790055
[Journal Article] The PtdIns(3, 4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death2010
- Author(s)
  Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
- Journal Title
  
  N a t u r e 465
  
  Pages: 497-501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death.2010
- Author(s)
  Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
- Journal Title
  
  Nature
  
  Volume: 465 Pages: 497-501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790055
[Journal Article] Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion2010
- Author(s)
  Hiramine Y, Emoto H, Takasuga S, Hiramatsu R.
- Journal Title
  
  J LipidRes 51
  
  Pages: 1424-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] The PtdIns(3,4)P_2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death2010
- Author(s)
  Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., Chida S., Tsuya Y., Takasuga S, Eguchi S., Asanuma K., Horie Y., Miura K., Davies E., Mitchell C., Yamazaki M., Hirai H., Takenawa T., Suzuki A., Sasaki T.
- Journal Title
  
  Nature (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.2010
- Author(s)
  Hiramine Y, Emoto H, Takasuga S, Hiramatsu R.
- Journal Title
  
  J.Lipid Res.
  
  Volume: 51 Pages: 1424-1431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790055
[Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase(MGAT)plays an important role in hepatic triacylglycerol secretion2010
- Author(s)
  Hiramine Y, Emoto H, Takasuga S, Hiramatsu R.
- Journal Title
  
  J.Lipid Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Mammalian phosphoinositide kinases and phosphatases.2009
- Author(s)
  Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A.
- Journal Title
  
  Prog LipidRes 48
  
  Pages: 307-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Mammalian phosphoinositide kinases and phosphatases2009
- Author(s)
  Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A.
- Journal Title
  
  Prog.Lipid Res. 48
  
  Pages: 307-343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
- Author(s)
  Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sane matsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
- Journal Title
  
  Science 324
  
  Pages: 384-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.2009
- Author(s)
  Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
- Journal Title
  
  Science 324
  
  Pages: 384-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Sequential Regulation of DOCK2 Dynamics by Two Phospholipids during Neutrophil Chemotaxis2009
- Author(s)
  Nishikimi A, Fukuhara H, Su W , Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shi basaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
- Journal Title
  
  Science (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790054
[Journal Article] Mammalian phosphoinositide kinases and phosphatases2009
- Author(s)
  Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M. & Suzuki, A.
- Journal Title
  
  Prog. Lipid Res.
  
  Volume: 48 Issue: 6 Pages: 307-343
- DOI
  10.1016/j.plipres.2009.06.001
- Data Source
  KAKENHI-PROJECT-21200075
[Journal Article] Thephysielogy of phosphoinositides.2007
- Author(s)
  T., Sasaki, J., Sasaki, T., Sakai, S., Takasuga, A., Suzuki
- Journal Title
  
  Biol Pharm Bull. 30
  
  Pages: 1599-1604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790041
[Journal Article] Control of cel lpolarity and motility by the PtdIn(〈3,4,5)P3 phosphatase SHIPI.2007
- Author(s)
  M., Nishio, K., Watanabe, J., Sasaki, C., Taya, S., Takasuga, R., Izuka, T., Balla, M., Yamazaki, H., Watanabe, R., Itoh, S., Kuroda, Y., Harie, I., Foerster, T.W., Mak, H., Yonekawa, J.M., Penninger
- Journal Title
  
  Nat. Cell Biol. 9
  
  Pages: 36-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790041
[Presentation] 代償的なINPP4B過剰発現によるPTEN遺伝子欠損の機能代替の機構2023
- Author(s)
  高須賀俊輔、佐々木雄彦、海老原敬
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06542
[Presentation] TIGIT mediates activation-induced cell death of ILC2s2022
- Author(s)
  Toshiki Yamada, Akane Fuchimukai, Megumi Tatematsu, Shunsuke Takasuga, Hideyuki Yoshida, Kazuko Shibuya, Akira Shibuya, Takashi Ebihara.
- Organizer
  The 51th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02707
[Presentation] Activation-induced cell death of ILC2 regulates chronic allergic inflammation2022
- Author(s)
  Toshiki Yamada, Megumi Tatematsu, Shunsuke Takasuga, Kenki Yamagata, Kazuko Shibuya, Akira Shibuya, Takechiyo Yamada, Takashi Ebihara.
- Organizer
  4TH INTERNATIONAL CONFERENCE ON INNATE LYMPHOID CELLS (ILC4)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02707
[Presentation] 肝特異的ホスファチジルグリセロールリン酸ホスファターゼ遺伝子欠損によるラロン型低身長症様疾患モデルマウス2021
- Author(s)
  高須賀俊輔、海老原敬、佐々木雄彦
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06542
[Presentation] 肝特異的ホスファチジルグリセロールリン酸ホスファターゼ遺伝子欠損によるラロン型低身長症様疾患モデルマウス2021
- Author(s)
  高須賀俊輔、海老原敬、佐々木雄彦
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02707
[Presentation] 肝特異的ホスファチジルグリセロールリン酸ホスファターゼ遺伝子欠損によるラロン型低身長症様疾患モデルマウス2021
- Author(s)
  高須賀俊輔、海老原敬、佐々木雄彦
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06623
[Presentation] The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency2018
- Author(s)
  Takehiko Sasaki, Satoshi Kofuji, Shunsuke Takasuga, Junko Sasaki
- Organizer
  Workshop on Frontiers in Phosphatase Research and Drug Discovery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03980
[Presentation] 心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割2015
- Author(s)
  木村洋貴、江口賢史、久場敬司、今井由美子、高須賀俊輔、伊藤玲悦、中村亮太郎、中西広樹、石川将己、佐々木純子、山崎正和、佐々木雄彦
- Organizer
  第38回日本分子生物学会年会・第88回生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26253006
[Presentation] イノシトールリン脂質研究の新しい方法論の提示2015
- Author(s)
  中西広樹、小藤智史、江口賢史、中村亮太郎、石川将己、高須賀俊輔、佐々木純子、佐々木雄彦
- Organizer
  第14回生命科学研究会
- Place of Presentation
  神奈川
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-26253006
[Presentation] Muscle-specific type III phosphatidylinositol phosphate kinase (PIPKIII/PIKfyve) deficiency improves glucose tolerance and insulin resistance in mice.2014
- Author(s)
  Shunsuke Takasuga, Takehiko Sasaki
- Organizer
  International symposium on "Homeostasis through development, life, and diseases."
- Place of Presentation
  Tojo Hall, Gunma Unicersity, Gunma
- Year and Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-26460059
[Presentation] ホスファチジルグリセロールリン酸(PGP)ホスファターゼの生理機能2013
- Author(s)
  高須賀俊輔、浅沼研、木村洋貴、高須賀緑、中西広樹、佐々木純子、山崎正和、妹尾春樹、佐々木雄彦
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24659124
[Presentation] Physiological function of phosphatidylinositol 3, 5-bisphosphate in mammalian cells2010
- Author(s)
  Takasuga S, Sasaki J, Iizuka R, Sato Y, Suzuki A, Sasaki T.
- Organizer
  The 60th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] Physiological function of phosphatidylinositol-3, 5-bisphosphate in vivo2010
- Author(s)
  Takasuga S, Sasaki J, Suzuki A, Sasaki T
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22790055
[Presentation] Physiological function of phosphatidylinositol-3,5-bisphosphate in vivo2010
- Author(s)
  Takasuga S, Sasaki J, Suzuki A, Sasaki T.
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22790055
[Presentation] Physiological function of phosphatidylinositol -3, 5-bisphosphate in vivo2010
- Author(s)
  Takasuga S, Sasaki J, Suzuki A, Sasaki T.
- Organizer
  The 62nd Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  Osaka, Japan
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] ホスファチジルイノシトール3リン酸5-キナーゼの生理機能解析2008
- Author(s)
  高須賀俊輔、佐々木純子、飯塚了太、佐藤美子、鈴木聡、佐々木雄彦
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] ホスファチジルイノシトール3リン酸5-キナーゼの生理機能2008
- Author(s)
  高須賀俊輔
- Organizer
  第2回群馬大・秋田大GCOE若手シンポジウム
- Place of Presentation
  前橋市
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] Physiological function of phosphatidylinositol 3-Phosphate 5-kinase Biochemistry and Molecular Biology2008
- Author(s)
  Takasuga S, Iizuka R, Sato Y, Suzuki A, Sasaki T.
- Organizer
  BMB2008, The 31st Annual Meeting of the Molecular Biology Society of Japan, The 81st Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Kobe, Japan
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] 哺乳動物細胞におけるホスファチジルイノシトール3, 5ニリン酸の生理機能2008
- Author(s)
  高須賀俊輔、佐々木純子、飯塚了太、佐藤美子、鈴木聡、佐々木雄彦
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2008-07-01
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] A Sac domain phosphoinositide phosphatase, Sac3 is a regulatory subunit of type III phosphatidylinositol phosphate kinase2008
- Author(s)
  Takasuga S, Sato Y, Iizuka R, Chida S, Sasaki J, Suzuki A, Sasaki T.
- Organizer
  The 8th International Conference on Protein Phosphatases
- Place of Presentation
  Maebashi, Japan
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] A Sac domain Phosphoinositide Phosphatase, Sac3 Is a Reguratory Sub unit of Type III Phosphatidylinositol Phosphate Kinase2008
- Author(s)
  Takasuga S, Sato Y, Iizuka R, Chid a S, Sasaki J, Suzuki A, Sasaki T
- Organizer
  8^<th> International Conference on Protein Phosphate ses
- Place of Presentation
  前橋テルサ(群馬県)
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-20790054
[Presentation] ホスファチジルイノシトール3リン酸5-キナーゼ(PIPK III)の機能解析2007
- Author(s)
  高須賀俊輔・佐々木純子・飯塚了太・鈴木聡・佐々木雄彦
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同年会(BMB2007)
- Place of Presentation
  パシフイコ横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-18790041
[Presentation] ホスファチジルグリセロールリン酸（PGP）ホスファターゼの生理機能
- Author(s)
  高須賀俊輔、浅沼研、木村洋貴、高須賀緑、中西広樹、佐々木純子、山崎正和、妹尾春樹、佐々木雄彦
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24659124
[]

1. SASAKI Takehiko (50333365)

# of Collaborated Projects: 9 results

# of Collaborated Products: 6 results
2. SASAKI Junko (30333371)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
3. EGUCHI Satoshi (70457117)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. IMAI Yumiko (50231163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OHTEKI Toshiaki (50233200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KOFUJI Satoshi (00508153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. Ebihara Takashi (20374407)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 久場敬司 (10451915)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 立松恵 (70725605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. INOUE Takao (50361605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAGUCHI Ryo (20080210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山崎正和 (40373378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中西広樹 (10466740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. 和田洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 櫨木薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKASUGA Shunsuke 高須賀 俊輔

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INPP4BによるPTEN機能代替の分子機構の解析Principal Investigator

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ミトコンドリア脂質代謝異常に起因する転写活性制御機構の解明Principal Investigator

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Elucidation of the mechanism of anticancer activity of the cancer suppressor gene INPP4BPrincipal Investigator

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Physiological function of phosphatidylinositol 3,5-bisphosphate in oligodendrocytesPrincipal Investigator

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Identification of phosphatidylglycerophosphate-binding proteins.Principal Investigator

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Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by PhosphoinositidesPrincipal Investigator

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TAKASUGA Shunsuke 高須賀俊輔

[Book] 実験医学増刊　イノシトールリン脂質におけるリン酸化クオリティ制御の病態生理学的意義2019