NUMAGUCHI Yasushi 沼口靖

Researcher Number	90378224
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: Nagoya University, School of Medicine, Associate Professor 2007: 名古屋大学, 医学部, 寄付講座准教授 2007: Nagoya University, 医学部, 寄附講座・准教授 2004 – 2006: 名古屋大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine
Keywords	Principal Investigator シンチグラフィ / 心筋サルベージ / アディポネクチン / 血管内皮前駆細胞 / 急性心筋梗塞 / アディポカイン / 脂肪酸代謝 / 再生医学 / 内皮前駆細胞 / 心筋梗塞 … More Except Principal Investigator … More 再生医療 / 血管新生 / 幹細胞 / 遺伝子治療 / 血管再生療法 / 血管再生 / 再生医学 / 血管内皮細胞 / endothelial progenitor cell / therapeutic angiogenesis / stem cell / endothelial cell / gene therapy / cell therapy / angiogenesis / regenerative medicine / 血管内皮前駆細胞 / 血管再生治療法 / 細胞治療 / Endothelial progenitor cells / Stem cells / Bone marrow cells / Growth factor / Gene therapy / Regenerative medicine / Vascular regeneration / Therapeutic angiogenesis / 炎症反応 / 血管透過性 / 虚血性心疾患 / 血管成長因子 / 内皮前駆細胞 / 骨髄細胞 / 成長因子 / 血管新生療法 / 高インスリン血症 / 心筋症 / 糖尿病性毛細血管傷害 / 高血糖 / 心筋リモデリング / ミトコンドリア / 心筋繊維化 / インスリン抵抗性 / 蛋白分解酵素 / 細胞内シグナル / 心不全 / 糖尿病性心筋症 / 糖尿病 / リポソーム / 磁性ナノ粒子 / ナノテクノロジー / マグネタイト / ドラッグデリバリーシステム / 間葉系幹細胞 / 細胞シート工学 / Notchシグナル Less

Role of diseased angiogenesis in diabetic cardiomyopathy and its significance for the invention of novel therapeutic strategy.
- Principal Investigator
  
  MUROHARA Toyoaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Analysis for the association between mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarctionPrincipal Investigator
- Principal Investigator
  
  NUMAGUCHI Yasushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Development of angiogenetic and regenerative therapy with regulation of Notch signaling
- Principal Investigator
  
  TAKESHITA Kyosuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
磁場と磁気ナノ粒子を用いた細胞シート工学とその再生医療への応用開発研究
- Principal Investigator
  
  室原豊明
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Investigation of the molecular mechanism of progenitor cell-mediated therapeutic angiogenesis
- Principal Investigator
  
  MUROHARA Toyoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Therapeutic angiogenesis using noble human VEGF-E chimeric genes and autologous bone marrow mononuclear cells
- Principal Investigator
  
  MUROHARA Toyoaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University

All 2009 2008 2007 2006 2004

All Journal Article Presentation

[Journal Article] Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men2009
- Author(s)
  Miura M, Numaguchi Y, Ishii M, Kubota R, Takeuchi T, Imamura A, Murakami R, Kondo T, Okumura K, Murohara T
- Journal Title
  
  Circ J (in press)
- NAID
  10025932869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Mesenchymal Stem Cell-Based Gene Therapy with Prostacyclin Synthase Enhanced Neovascularization in Hindlimb Ischemia2009
- Author(s)
  Ishii M, Numaguchi Y, Okumura K, Kubota R, Ma X, Murakami R, Naruse K, Murohara T
- Journal Title
  
  Atherosclerosis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis2009
- Author(s)
  Numaguchi Y, Ishii M, Kubota R, Morita Y, Yamamoto K, Matsushita T, Okumura K, Murohara T.
- Journal Title
  
  Arterioscler.Thromb.Vasc.Biol. 29
  
  Pages: 2102-2108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249045
[Journal Article] Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men.2009
- Author(s)
  Miura M, Numaguchi Y, Ishii M, Kubota R, Takeuchi T, imamura A, Murakami R, Kondo T, Okumura K, Murohara T.
- Journal Title
  
  Circ J. (in press)
- NAID
  10025932869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Nifedipine improves endothelial function : role of endothelial progenitor cell.2008
- Author(s)
  Sugiura T, Kondo T, Kureishi-Bando Y, Numaguchi Y, Yoshida O, Dohi Y, Kimura G, Ueda R, Rabelink TJ, Murohara T.
- Journal Title
  
  Hypertension. 52
  
  Pages: 491-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249045
[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction2008
- Author(s)
  Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T
- Journal Title
  
  Am J Cardiol 101(12)
  
  Pages: 1712-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590859
[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction2008
- Author(s)
  Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T
- Journal Title
  
  Am J Cardiol 101(12)
  
  Pages: 1712-1715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardiai infarction.2008
- Author(s)
  Shibata R, Numaguchi Y. Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T.
- Journal Title
  
  Am J Cardiol 101(12)
  
  Pages: 1712-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Usefulness of Adiponectin to Predict Myocardial Salvage Following Successful Reperfusion in Patients with Acute Myocardial Infarction2008
- Author(s)
  Shibata R, Numaguchi Y, et. al.
- Journal Title
  
  American Journal of Cardiology 102(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Role of Bradykinin, Nitric Oxide, and Angiotensin II Type 2 Receptor in Imidapril-Induced Angiogenesis.2008
- Author(s)
  Li P, Numaguchi Y, et. al.
- Journal Title
  
  Hypertension 51
  
  Pages: 252-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis2008
- Author(s)
  Li P, Kondo T, Numaguchi Y, Kobayashi K, Aoki M, Inoue N, Okumura K, Murohara T
- Journal Title
  
  Hypertension 51(2)
  
  Pages: 252-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects : the significance of plasma adiponectin levels2008
- Author(s)
  Imamura A, Takahashi R, Murakami R, Kataoka H, Cheng XW, Numaguchi Y, Murohara T, Okumura K
- Journal Title
  
  Eur J Endocrinol 158(2)
  
  Pages: 189-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Nifedipine improves endothelial function : role of endothelial progenitor cells2008
- Author(s)
  Sugiura T, Kondo T, Kureishi-Bando Y, Numaguchi Y, Yoshida O, Dohi Y, Kimura G, Ueda R, Rabelink TJ, Murohara T
- Journal Title
  
  Hypertension 52(3)
  
  Pages: 491-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Angiotensin II Receptor Blocker Inhibits Neointimal Hype-plasia Through Regulation of Smooth Muscle-like Progenitor Cells.2007
- Author(s)
  Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murohara T.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27
  
  Pages: 2363-2369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men.2007
- Author(s)
  Torigoe M, Numaguchi Y, et. al.
- Journal Title
  
  Clinical Endocrinology 67
  
  Pages: 276-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes.2007
- Author(s)
  Inoue N, Kondo T, Kobayashi K, Aoki M, Numaguchi Y, Shibuya M, Murohara T
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27(In press)
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Angiotensin II Receptor Blocker Inhibits Neointimal Hyperplasia Through Regulation of Smooth Muscle-like Progenitor Cells2007
- Author(s)
  Yamada, T, Kondo, T, Numaguchi, Y, Tsuzuki, M, Matsubara, T, Manabe, I, Sata, M, Nagai, R, Murohara, T
- Journal Title
  
  Arterioscler. Thromb. Vase. Biol 27
  
  Pages: 2363-2369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes.2007
- Author(s)
  Inoue N, Kondo T, Kobayashi K, Aoki M, Numaguchi Y, Shibuya M, Murohara T.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27
  
  Pages: 99-105
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Angiotensin II Receptor Blocker Inhibits Neointimal Hyperplasia Through Regulation of Smooth Muscle-like Progenitor Cells.2007
- Author(s)
  Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murobara T.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27
  
  Pages: 2363-2369
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes.2007
- Author(s)
  Inoue N, Kondo T, Kobayashi K, Aoki M, Numaguchi Y, Shibuya M, Murohara T.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27
  
  Pages: 99-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659201
[Journal Article] Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes2007
- Author(s)
  Inoue, N, Kondo, T, Kobayashi, K, Aoki, M, Numaguchi, Y, Shibuya, M, Murohara, T
- Journal Title
  
  Arterioscler. Thromb. Vasa Biol 27
  
  Pages: 99-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Angiotensin II Receptor Blocker Inhibits Neointimal Hyperplasia Through Regulation of Smooth Muscle-like Progenitor Cells.2007
- Author(s)
  Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murohara T.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 27
  
  Pages: 2363-2369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659201
[Journal Article] Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells2007
- Author(s)
  Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murohara T
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27(11)
  
  Pages: 2363-2369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590811
[Journal Article] The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.2006
- Author(s)
  Numaguchi Y, Sone T, Okumura K, Morita Y, Kubota R, Yokouchi K, Imai H, Harada M, Kondo T, Murohara T
- Journal Title
  
  Circulation 114(Suppl.1)
- Data Source
  KAKENHI-PROJECT-18390232
[Journal Article] Catheter-based prostacyclin synthase gene transfer prevents in-stent restenosis in rabbit atheromatous arteries.2004
- Author(s)
  Numaguchi, Murohara et al.
- Journal Title
  
  Cardiovascular Research 61
  
  Pages: 177-185
- Data Source
  KAKENHI-PROJECT-16390221
[Presentation] Ablation of AngiotensinIV Receptor Attenuates Hypofibrinolysis via PAI-1 Downreguiation and Reduces Thromboembolism in Injured Arteries.2008
- Author(s)
  沼口靖
- Organizer
  ATVB Corference2008
- Place of Presentation
  CNNセンター(アトランタ)
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 新規アンギオテンシン受容体(AT4R)の動脈傷害後における血栓閉鎖に関する役割について2008
- Author(s)
  沼口靖
- Organizer
  日本循環器学会総会
- Place of Presentation
  福岡マリンメッセ
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 再生医療治療時におけるカルシウム拮抗薬シルニジピンの腎機能保護効果について2008
- Author(s)
  沼口靖
- Organizer
  日本循環器学会総会
- Place of Presentation
  福岡マリンメッセ
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 磁性ナノ微粒子を用いた間葉系幹細胞シートの下肢虚血治療への応用2008
- Author(s)
  沼口靖
- Organizer
  第32回日本鉄バイオサイエンス学会
- Place of Presentation
  ウェデイングプラザアラスカ青森県
- Year and Date
  2008-09-14
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] Ablation of Insulin-Regulated Aminopeptidase(IRAP/AT4R)Attenuates Lipid Accumulation and Plaque Rupture in ApoE Deficient Mice2008
- Author(s)
  沼口靖
- Organizer
  アメリカ心臓協会年次学会2008
- Place of Presentation
  アメリカルイジアナ州ニューオリンズ市コンヴェンションセンター
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 医工連携研究の成果である細胞シートの虚血下肢血流改善効果について2008
- Author(s)
  沼口靖
- Organizer
  日本循環器学会総会
- Place of Presentation
  福岡マリンメッセ
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 磁性ナノ微粒子を用いた開葉系幹細胞シートの下肢虚血治療への応用2008
- Author(s)
  沼口靖
- Organizer
  第32回日本鉄バイオサイエンス学会
- Place of Presentation
  ウェディングプラザアラスカ(青森県)
- Year and Date
  2008-09-14
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] 虚血時血管新生におけるアンギオテンシンIIの役割2008
- Author(s)
  沼口靖
- Organizer
  第16回日本血管生物医学会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] Ablation of AngiotensinIV Receptor Attenuates Hypofibrinolysis via PAI-1Downregulation and Reduces Thromboembolism in Injured Arteries2008
- Author(s)
  沼口靖
- Organizer
  ATVB Conference2008
- Place of Presentation
  CNNセンターアトランタ
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] Ablation of Insulin-Regulated Aminopeptidase (IRAP/AT4R) Attenuates Lipid Accumulation and Plaque Rupture in ApoE Deficient Mice2008
- Author(s)
  沼口靖
- Organizer
  アメリカ心臓協会年次学会2008
- Place of Presentation
  アメリカルイジアナ州ニューオリンズ市コンヴェンションセンター
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590811
[Presentation] A novel nanotechnology-based cell sheet strategy for therapeutic neovascularization: multilayered mesenchymal stem cell sheet with magnetite nanoparticle improves therapeutic efficacy of ischemic neovascularization.2007
- Author(s)
  Ishii M, Numaguchi Y, Kubota R, Shimizu K, Ito A, Sone T, Honda H, Murobara T.
- Organizer
  American Heart Association, 2007
- Place of Presentation
  Orlando, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19659201

1. MUROHARA Toyoaki (90299503)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. SHINTANI Satoshi (20309777)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SHIBATA Rei (70343689)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. TAKESHITA Kyosuke (70444403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KONDO Takahisa (00303644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. KOMORI Kimihiro (40225587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. BANDO Yasuko (60452190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. MAEDA Kengo (80456673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIBUYA Masafumi (10107427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 本多裕之 (70209328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NUMAGUCHI Yasushi 沼口 靖

Research Projects

Research Products

Co-Researchers

Role of diseased angiogenesis in diabetic cardiomyopathy and its significance for the invention of novel therapeutic strategy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for the association between mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of angiogenetic and regenerative therapy with regulation of Notch signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

磁場と磁気ナノ粒子を用いた細胞シート工学とその再生医療への応用開発研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the molecular mechanism of progenitor cell-mediated therapeutic angiogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic angiogenesis using noble human VEGF-E chimeric genes and autologous bone marrow mononuclear cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mesenchymal Stem Cell-Based Gene Therapy with Prostacyclin Synthase Enhanced Neovascularization in Hindlimb Ischemia2009

Author(s)

Journal Title

Data Source

[Journal Article] Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis2009

Author(s)

Journal Title

Data Source

[Journal Article] Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Nifedipine improves endothelial function : role of endothelial progenitor cell.2008

Author(s)

Journal Title

Data Source

[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction2008

Author(s)

Journal Title

Data Source

[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction2008

Author(s)

Journal Title

Data Source

[Journal Article] Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardiai infarction.2008

Author(s)

Journal Title

Data Source

[Journal Article] Usefulness of Adiponectin to Predict Myocardial Salvage Following Successful Reperfusion in Patients with Acute Myocardial Infarction2008

Author(s)

Journal Title

Data Source

[Journal Article] Role of Bradykinin, Nitric Oxide, and Angiotensin II Type 2 Receptor in Imidapril-Induced Angiogenesis.2008

Author(s)

NUMAGUCHI Yasushi 沼口靖