uramaru naoto 浦丸直人

… Alternative Names

Uramaru Naoto 浦丸直人

URAMARU Naoto 浦丸直人

Less

Researcher Number	90424069
Other IDs
Affiliation (Current)	2025: 埼玉県立大学, 保健医療福祉学部, 准教授 2025: 日本薬科大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	2025: 埼玉県立大学, 保健医療福祉学部, 准教授 2021 – 2023: 日本薬科大学, 薬学部, 講師 2013 – 2019: 日本薬科大学, 薬学部, 講師 2012 – 2013: 日本薬科大学, 薬学部, 助教 2012: 日本薬科大学, 薬学部
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Environmental and hygienic pharmacy / Environmental pharmacy Except Principal Investigator Medical pharmacy / Hygiene and public health / Pharmacology in pharmacy / Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 薬物代謝 / 薬物アレルギー / 薬物相互作用 / 生活習慣病 / 非アルコール性脂肪性肝疾患 / シトクロムP450 / 薬学 / 構造活性相関 / ドラッグデザイン / 代謝的活性化 / 環境化学物質 … More Except Principal Investigator … More 核内受容体 / 甲状腺ホルモン撹乱 / 水酸化代謝物 / 代謝的活性化 / 内分泌撹乱 / ブロム化難燃剤 / カテコールアミン / メラトニン / 乳腺上皮細胞 / トランスポーター / 乳児 / 生理活性物質 / ノルアドレナリン / セロトニン / 母乳 / 環境 / 可塑剤 / 難燃剤 / ビスフェノール類 / ポリ塩化ビフェニル類 / 複合曝露 / 免疫 / 遺伝子発現 / 環境化学物質 / 複合曝露影響 / 免疫毒性 / 化学物質 / IL-17 / STAT3 / トファシチニブ / 抗ヒスタミン薬 / 掻痒 / JAK/STAT / Traf3ip2/Act1 / 乾癬 / 内分泌撹乱作用 / 甲状腺ホルモン受容体 / 甲状腺ホルモン代謝 / PCB / プロテインジスルフィドイソメラーゼ / 核内レセプター / プロテインジスルフィッドイソメラーゼ / 甲状腺ホルモン Less

非アルコール性脂肪肝疾患を改善する植物由来成分の探索と予防改善薬創生への応用Principal Investigator
- Principal Investigator
  
  浦丸直人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saitama Prefectural University
Changes in expression/activity of Cytochrome P450 in simple fatty liver and steatohepatitisPrincipal Investigator
- Principal Investigator
  
  Uramaru Naoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nihon Pharmaceutical University
Evaluation of physiological roles of various physiologically active substances in breast milk
- Principal Investigator
  
  MAEDA TOMOJI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nihon Pharmaceutical University
Predictability of pathogenesis of allergic contact dermatitis based on specific chemical structure caused by metabolic activation.Principal Investigator
- Principal Investigator
  
  URAMARU NAOTO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Nihon Pharmaceutical University
Effects of chemical mixtures contained in foods on immune response via nuclear receptors.
- Principal Investigator
  
  Kojima Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Hokkaido Institute of Public Health
Estimation of target proteins of hydroxylated PCB and brominated flame retardants for thyroid hormone disruption and the influence by radiation
- Principal Investigator
  
  Kitamura Shigeyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nihon Pharmaceutical University
Elucidation of pathogenesis of psoriasis using TRAF3IP/2Act 1 deficient mice and development of new therapy
- Principal Investigator
  
  Tishio Inoue
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Nihon Pharmaceutical University
The metabolic activation and the structural requirement in the allergic reactions of drugs and environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  URAMARU NAOTO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nihon Pharmaceutical University
Determination of targets for thyroid hormone disruption by brominated flame retardants
- Principal Investigator
  
  KITAMURA Shigeyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nihon Pharmaceutical University

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Rhododendrol, a reductive metabolite of raspberry ketone, suppresses the differentiation of 3T3-L1 cells into adipocytes.2023
- Author(s)
  Uramaru N, Kawashima A, Osabe M, Higuchi T.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 27(2) Issue: 2 Pages: 51-51
- DOI
  10.3892/mmr.2023.12938
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11599
[Journal Article] Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis2023
- Author(s)
  Kawashima Azusa、Uramaru Naoto、Mikuma Toshiyasu、Osabe Makoto、Higuchi Toshiyuki
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 10 Issue: 6 Pages: 265-277
- DOI
  10.2131/fts.10.265
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11599
[Journal Article] Carbonic anhydrase 3 increases during liver adipogenesis even in pre‐obesity, and its inhibitors reduce liver adipose accumulation2022
- Author(s)
  Yamamoto Hiroyuki、Uramaru Naoto、Kawashima Azusa、Higuchi Toshiyuki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 4 Pages: 827-834
- DOI
  10.1002/2211-5463.13376
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11599
[Journal Article] Selective Synthesis and Photoluminescence Study of Pyrazolopyridopyridazine Diones and N-Aminopyrazolopyrrolopyridine Diones2020
- Author(s)
  Tseng Ching-Chun、Chung Cheng-Yen、Tsai Shuo-En、Takayama Hiroyuki、Uramaru Naoto、Lin Chin-Yu、Wong Fung Fuh
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 10 Pages: 2409-2409
- DOI
  10.3390/molecules25102409
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARalpha-mediated transcriptional activation.2019
- Author(s)
  1.Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 133 Pages: 110792-110792
- DOI
  10.1016/j.fct.2019.110792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10611, KAKENHI-PROJECT-18H03035, KAKENHI-PROJECT-17K15493
[Journal Article] Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors2019
- Author(s)
  Hiroyuki Kojima, Shinji Takeuchi, Seigo Sanoh, Katsuhiro Okuda, Shigeyuki Kitamura, Naoto Uramaru, Kazumi Sugihara, Kouichi Yoshinari
- Journal Title
  
  Toxicology, 413(2),48-55,
  
  Volume: 413 Pages: 48-55
- DOI
  10.1016/j.tox.2018.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08401, KAKENHI-PROJECT-17K15493, KAKENHI-PROJECT-18H03035, KAKENHI-PROJECT-16K00559
[Journal Article] Synthesis and evaluation of in vitro bioactivity for polysubstituted N-arylpyrazole derivatives2019
- Author(s)
  Uramaru Naoto、Chang En-Chiuan、Yen Wan-Ping、Yeh Mou-Yung、Juang Shin-Hun、Wong Fung Fuh
- Journal Title
  
  Arabian Journal of Chemistry
  
  Volume: 12 Issue: 8 Pages: 1908-1917
- DOI
  10.1016/j.arabjc.2014.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] Selective synthesis of functionalized pyrazoles from 5-amino-1H-pyrazole-4-carbaldehydes with sodium nitrite: 5-Amino-4-nitrosopyrazoles and pyrazole-4-carbaldehydes2019
- Author(s)
  Hsiao Rong-Hong、Tseng Ching-Chun、Xie Jia-Jun、Tsai Shuo-En、Uramaru Naoto、Lin Ching-Ya、Chern Ching-Yuh、Wong Fung Fuh
- Journal Title
  
  Tetrahedron
  
  Volume: 75 Issue: 33 Pages: 4561-4569
- DOI
  10.1016/j.tet.2019.06.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] Activation of PXR, CAR and PPARalpha by pyrethroid pesticides and effect of the metabolism by rat liver microsomes.2019
- Author(s)
  2.Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.
- Journal Title
  
  Heliyon
  
  Volume: 5 Issue: 9 Pages: e02466-e02466
- DOI
  10.1016/j.heliyon.2019.e02466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10611, KAKENHI-PROJECT-18H03035, KAKENHI-PROJECT-17K15493
[Journal Article] Identification of hepatic thyroid hormone-responsive genes in neonatal rats: Potential targets for thyroid hormone-disrupting chemicals.2018
- Author(s)
  Fujimoto N., Kitamura S., Uramaru N., Miyagawa S., Iguchi T.
- Journal Title
  
  Toxicology Letters
  
  Volume: 286 Pages: 48-53
- DOI
  10.1016/j.toxlet.2018.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15493, KAKENHI-PLANNED-17H06432, KAKENHI-PROJECT-15H04396, KAKENHI-PROJECT-26440173, KAKENHI-PROJECT-18H02474, KAKENHI-PROJECT-16K00559
[Journal Article] Efficient acid catalytic synthesis of pyrazolopyrimidines from 1H-pyrazol-5-yl-N,N-dimethylformamidines with cyanamide.2018
- Author(s)
  Tsai S. E., Yen W. P., Tseng C. C., Xie J. J., Liou M. Y., Li Y. T., Uramaru N., Wong F. F.
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Issue: 22 Pages: 2787-2791
- DOI
  10.1016/j.tet.2018.04.048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] Altered expression of Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption.2017
- Author(s)
  Matsubara K et al.
- Journal Title
  
  J Appl Toxicol
  
  Volume: - Issue: 9 Pages: 1030-1035
- DOI
  10.1002/jat.3452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440173, KAKENHI-PROJECT-16K00559, KAKENHI-PROJECT-17K15493, KAKENHI-PLANNED-17H06432, KAKENHI-PROJECT-15H04396
[Journal Article] Synthesis and antiproliferative activity of 3α-hydroxyl-3β-methoxymethyl-5α-pregnan-20-one with a C-21 hydrophilic substituent.2017
- Author(s)
  Tsai S. E., Lee J. C., Uramaru, N., Takayama H., Huang G. J., Wong F. F.
- Journal Title
  
  Heteroatom Chemistry
  
  Volume: 28(3) Issue: 3 Pages: e21372-e21372
- DOI
  10.1002/hc.21372
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] Protective effects of tormentic Acid, a major component of suspension cultures of eriobotrya japonica cells, on acetaminophen-induced hepatotoxicity in mice.2017
- Author(s)
  Jiang W. P., Huang S. S., Matsuda Y., Saito H., Uramaru N., Ho H. Y., Wu J. B., Huang G. J.
- Journal Title
  
  Molecules
  
  Volume: 22(5) Issue: 5 Pages: 830-830
- DOI
  10.3390/molecules22050830
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] One-flask synthesis of pyrazolo[3,4-d]pyrimidines from 5-aminopyrazoles and mechanistic study.2017
- Author(s)
  Yen W. P., Tsai S. E., Uramaru N., Takayama H., Wong F.F.
- Journal Title
  
  Molecules, 22(5), 820/1-820/12 (2017).
  
  Volume: 22(5) Issue: 5 Pages: 820-820
- DOI
  10.3390/molecules22050820
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Journal Article] 肝細胞肥大の毒性学的特徴の解明に向けた農薬のラット反復投与毒性試験結果のデータベース構築2017
- Author(s)
  増田茜、増田雅美、川野拓歩、橘内陽子、中山晴香、中島宏之、小島弘幸、北村繁幸、浦丸直人、保坂卓臣、佐々木崇光、吉成浩一
- Journal Title
  
  薬学雑誌
  
  Volume: 137 Pages: 611-622
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08791
[Journal Article] Construction of the Database of Rat Repeated-dose Toxicity Tests of Pesticides for the Toxicological Characterization of Hepatocyte Hypertrophy2017
- Author(s)
  増田茜、増田雅美、中島宏之、小島弘幸、北村繁幸、浦丸直人、保坂卓臣、佐々木崇光、吉成浩一―
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 5 Pages: 611-622
- DOI
  10.1248/yakushi.16-00259
- NAID
  130005631433
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-05-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-16K00559, KAKENHI-PROJECT-17K15493
[Journal Article] Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities2016
- Author(s)
  Chieri Fujino, Yuki Tamura, Satoko Tange, Hiroyuki Nakajima, Seigo Sanoh, Yoko Watanabe, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 5 Pages: 677-691
- DOI
  10.2131/jts.41.677
- NAID
  130005266225
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04780, KAKENHI-PROJECT-15K08791, KAKENHI-PROJECT-16K00559
[Journal Article] In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities.2016
- Author(s)
  Tange S., Fujimoto N., Uramaru N., Wong F. F., Sugihara K., Ohta S., Kitamura S.
- Journal Title
  
  Environ Toxicol Pharmacol
  
  Volume: 41 Pages: 289-297
- DOI
  10.1016/j.etap.2015.08.014
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340049, KAKENHI-PROJECT-16K00559
[Journal Article] Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues2015
- Author(s)
  Ozaki H., Sugihara K., Tamura Y., Fujino C., Watanabe Y., Uramaru N., Sone T., Ohta S., Kitamura S.
- Journal Title
  
  Food Chem Toxicol
  
  Volume: 86. Pages: 116-123
- DOI
  10.1016/j.fct.2015.08.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25340049
[Journal Article] Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.2015
- Author(s)
  Yoko Watanabe, Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Seigo Sanoh, Kazumi Sugihara, Shigeyuki Kitamura, and Shigeru Ohta
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 282 Issue: 2 Pages: 119-128
- DOI
  10.1016/j.taap.2014.12.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-25340049, KAKENHI-PROJECT-24390172
[Journal Article] Basic Principles of Interpretation of Hepatocellular Hypertrophy in Risk Assessment in Japan2015
- Author(s)
  Yoshida M., Umemura T., Kojima H., Inoue K., Takahashi M., Uramaru N., Kitamura S., Abe K., Tohkin M., Ozawa S., Yoshinari K.,
- Journal Title
  
  Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
  
  Volume: 56 Issue: 2 Pages: 42-48
- DOI
  10.3358/shokueishi.56.42
- NAID
  130005067294
- ISSN
  0015-6426, 1882-1006
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25340049, KAKENHI-PROJECT-24390172
[Journal Article] Structure-activity relationship of a series of 17 parabens and related compounds for histamine release in rat peritoneal mast cells and skin allergic reaction in guinea pigs2014
- Author(s)
  Uramaru N., Inoue T., Watanabe Y., Shigematsu H., Ohta S., Kitamura S.
- Journal Title
  
  The Journal of Toxicological Sciences, 39(1) 83-90 (201
  
  Volume: 39 Pages: 83-90
- NAID
  130004447118
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25340049
[Journal Article] In vitro metabolism of cis-and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities2014
- Author(s)
  Tange, S., Fujimoto, N., Uramaru, N., Sugihara, K., Ohta, S., Kitamura, S
- Journal Title
  
  Environ. Toxicol. Pharmacol
  
  Volume: 37 Issue: 3 Pages: 996-1005
- DOI
  10.1016/j.etap.2014.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23510076, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Structure-activity relationship of a series of 17 parabens and related compounds for histamine release in rat peritoneal mast cells and skin allergic reaction in guinea pigs2014
- Author(s)
  Uramaru N., Inoue T., Watanabe Y., Shigematsu H., Ohta S., Kitamura S
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 39 Issue: 1 Pages: 83-90
- DOI
  10.2131/jts.39.83
- NAID
  130004447118
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790126
[Journal Article] Structure-activity relationship of a series of 17 parabens and related compounds for histamine release in rat peritoneal mast cells and skin allergic reaction in guinea pigs2014
- Author(s)
  Uramaru et al.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 39(1) Pages: 83-90
- NAID
  130004447118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25340049
[Journal Article] Transesterification of a series of 12 parabens by liver and small-intestinal microsomes of rats and humans2014
- Author(s)
  Fujino C., Watanabe Y., Uramaru N., Kitamura S
- Journal Title
  
  Food Chem Toxicol
  
  Volume: 64 Pages: 361-368
- DOI
  10.1016/j.fct.2013.12.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Comparative study on transcriptional activity of 17 parabens mediated by estrogen receptor α and β and androgen receptor2013
- Author(s)
  Watanabe Y., Kojima H., Takeuchi S., Uramaru N., Ohta S, Kitamura S
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 57 Pages: 227-234
- DOI
  10.1016/j.fct.2013.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-24390172, KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues2013
- Author(s)
  Ozaki H., Sugihara K., WatanabeY., Fujino C., Uramaru N., Sone T., Ohta S., Kitamura S
- Journal Title
  
  Xenobiotica
  
  Volume: (in press) Issue: 12 Pages: 1064-1072
- DOI
  10.3109/00498254.2013.802059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Strain Difference of Oxidative Metabolism of the Sedative-hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 <i>In Vivo</i> and <i>In Vitro</i> in Rats2013
- Author(s)
  Tanoue C., Sugihara K., Uramaru N., Watanabe Y., Tayama Y., Ohta S., Kitamura S
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Issue: 3 Pages: 269-273
- DOI
  10.2133/dmpk.DMPK-12-NT-103
- NAID
  130004463299
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071
[Journal Article] 2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes2013
- Author(s)
  Kamikyouden N., Sugihara K., Watanabe Y., Uramaru N., Murahashi T., Kuroyanagi M., Sanoh S., Ohta S., Kitamura S
- Journal Title
  
  Xenobiotica
  
  Volume: 43(6) Issue: 6 Pages: 514-519
- DOI
  10.3109/00498254.2012.742217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23659053, KAKENHI-PROJECT-24790111, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Strain Difference of Oxidative Metabolism of the Sedative-Hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 in Vivo and in Vitro in Rats2013
- Author(s)
  Tanoue C., Sugihara K., Uramaru N., Watanabe Y., Tayama Y., Ohta S., Kitamura S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28(3) Pages: 269-273
- NAID
  130004463299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790126
[Journal Article] Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity.2013
- Author(s)
  Ryo Shimizu, Masafumi Yamaguchi, Naoto Uramaru, Hiroaki Kuroki, Shigeru Ohta, Shigeyuki Kitamura, Kazumi Sugihara
- Journal Title
  
  Toxicology
  
  Volume: 314 Issue: 1 Pages: 22-29
- DOI
  10.1016/j.tox.2013.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710071, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Cell type-dependent agonist/antagonist activities of polybrominated diphenyl ethers2013
- Author(s)
  Nakamura N, Matsubara K, Sanoh S, Ohta S, Uramaru N, Kitamura S, Yamaguchi M, Sugihara K, Fujimoto N
- Journal Title
  
  Toxicol Lett
  
  Volume: 223(2) Issue: 2 Pages: 192-7
- DOI
  10.1016/j.toxlet.2013.09.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23510076, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Prediction of Human Metabolism of the Sedative-Hypnotic Zaleplon Using Chimeric Mice Transplanted with Human Hepatocytes2013
- Author(s)
  Tanoue C., Sugihara K., Uramaru N., Tayama Y., Watanabe Y., Horie T., Ohta S., Kitamura S
- Journal Title
  
  Xenobiotica
  
  Volume: (in press) Issue: 11 Pages: 956-962
- DOI
  10.3109/00498254.2013.788232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25340049
[Journal Article] Similarities in the Endocrine-Disrupting Potencies of Indoor Dust and Flame Retardants by Using Human Osteosarcoma (U2OS) Cell-Based Reporter Gene Assays2013
- Author(s)
  Suzuki, G.
- Journal Title
  
  Environmental Science and Technology
  
  Volume: 47 Issue: 6 Pages: 2898-2908
- DOI
  10.1021/es304691a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221003, KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-23681011, KAKENHI-PROJECT-24790126, KAKENHI-PROJECT-25281050, KAKENHI-PROJECT-25340049
[Journal Article] Polycyclic N-Heterocyclic Compounds 84: Reaction of N-(pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-yl)amidines with Hydroxylamine Hydrochloride2013
- Author(s)
  K. Okuda, R. Ide, N. Uramaru, T. Hirota
- Journal Title
  
  Journal of Heterocyclic Chemistry
  
  Volume: in press Issue: 3 Pages: 880-887
- DOI
  10.1002/jhet.2033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790126
[Journal Article] Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats2012
- Author(s)
  Yao, H. T., Chang, Y. W., Uramaru, N., Watanabe, Y.,. Kitamura, S.,Kuo, Y. H., Lii, C.K., Yeh, T.K
- Journal Title
  
  J. Ethnopharmacol
  
  Volume: 142(1) Pages: 121-128
- Data Source
  KAKENHI-PROJECT-22510071
[Journal Article] Effects of polybrominated diphenyl ethers (PBDEs) and their derivatives on protein disulfide isomerase activity and growth hormone release of GH3 cells.2012
- Author(s)
  Hashimoto S, Yoshimura H, Okada K, Uramaru N, Sugihara K, Kitamura S, and Imaoka S.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 25(3) Issue: 3 Pages: 656-63
- DOI
  10.1021/tx200374s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310045, KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-23655162
[Journal Article] Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats2012
- Author(s)
  Yao H.T., Chang Y.W., Uramaru N., Watanabe Y., Kitamura S., Kuo Y.H., Lii C.K., Yeh T.K
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 142(1) Issue: 1 Pages: 121-8
- DOI
  10.1016/j.jep.2012.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790126
[Journal Article] Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes2012
- Author(s)
  Sanoh S., Horiguchi A., Sugihara K., Kotake Y., Tayama Y., Uramaru N., Ohshita H., Tateno C., Horie T., Kitamura S., Ohta S
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 40(2) Issue: 2 Pages: 2267-2272
- DOI
  10.1124/dmd.111.040923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071, KAKENHI-PROJECT-22790109, KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23659053
[Journal Article] Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes2012
- Author(s)
  Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 40(12) Issue: 12 Pages: 2267-72
- DOI
  10.1124/dmd.112.047555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-23390030, KAKENHI-PROJECT-23659053, KAKENHI-PROJECT-24651061, KAKENHI-PROJECT-24790111, KAKENHI-PROJECT-24790126
[Journal Article] Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics2010
- Author(s)
  Uramaru N., Shigematsu H., Toda A., Eyanagi R., Kitamura S., Ohta S.
- Journal Title
  
  J Med Chem
  
  Volume: 53 Issue: 24 Pages: 8727-8733
- DOI
  10.1021/jm101208x
- Data Source
  KAKENHI-PROJECT-22510071
[Journal Article] Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics2010
- Author(s)
  Uramaru, et al.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 53 Pages: 8727-8733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] 単純性脂肪肝および脂肪肝炎におけるシトクロムP450 1A2 発現/活性の反転変動2024
- Author(s)
  川嶋梓、浦丸直人、三熊敏靖、長部誠、樋口敏幸
- Organizer
  第144年会日本薬学会
- Data Source
  KAKENHI-PROJECT-21K11599
[Presentation] ロドデノールは3T3-L1細胞の脂肪細胞への分化を抑制する2023
- Author(s)
  浦丸直人、川嶋梓、長部誠、樋口敏幸
- Organizer
  フォーラム2023衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K11599
[Presentation] Rhododendrol, a reductive metabolite of raspberry ketone, suppresses the differentiation of 3T3-L1 cells into adipocytes.2023
- Author(s)
  Uramaru N., Kawashima A., Osabe M., and Higuchi T.
- Organizer
  The International Conference for Public Health, Environment, and Education for Sustainable Development Goals and Lifelong Learning
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11599
[Presentation] ロドデノールの3T3-L1前駆脂肪細胞における脂肪蓄積および脂肪細胞分化制御因子発現に対する抑制作用2022
- Author(s)
  浦丸直人、川嶋梓、長部誠、樋口敏幸
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K11599
[Presentation] NAFLからNASHへの進展過程におけるシトクロム P450分子種発現変動2022
- Author(s)
  川嶋（片桐）梓、浦丸直人、長部誠、樋口敏幸
- Organizer
  フォーラム2022:衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K11599
[Presentation] ラズベリーケトンの還元代謝物であるロドデノールによる脂肪蓄積抑制2019
- Author(s)
  浦丸直人，鈴木智貴，木根淵有香，川村諒，渡部容子，長部誠，樋口敏幸
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] PM2.5由来抽出物質によるTissue factor の発現誘導2019
- Author(s)
  小畑りさ，種田千夏，村橋毅，浦丸直人，長部誠，渡部容子，樋口敏幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] Common behavioral characteristics in the mice maternally exposed to different types of dioxins.2019
- Author(s)
  Maekawa F., Kimura E., Uramaru N., Suzuki G.
- Organizer
  9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] ラズベリーケトンの還元的代謝および3T3-L1 細胞の脂肪化抑制2019
- Author(s)
  浦丸直人，坂本佳澄，鈴木智貴，木根淵有香，川村涼，渡部容子，北村繁幸，樋口敏幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] Behavioral impairments of infant and adult mice exposed to 2,3,7,8-tetrabromodibenzofuran in utero and via lactation.2019
- Author(s)
  Kimura E., Uramaru N., Suzuki G., Mekawa F.
- Organizer
  58th Annual Meeting and ToxExpo (Society of Toxicology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] 高脂肪食負荷および通常食ラットにおけるシトクロムP450 活性/ 発現の比較検討2018
- Author(s)
  浦丸直人，島田沙保，厚川雄大，渡部容子，樋口敏幸
- Organizer
  フォーラム2018　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] フタル酸エステルとその代謝物が核内受容体PXRおよびPPARalphaの転写活性に及ぼす影響2018
- Author(s)
  佐藤志穂、渡部容子、立花研、浦丸直人、小島弘幸、吉成浩一、樋口敏幸、北村繁幸
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] 環境中に存在する臭素系ダイオキシンの発達期曝露により誘導される行動異常2018
- Author(s)
  木村栄輝，鈴木剛，浦丸直人，前川文彦
- Organizer
  第189回日仏生物学会例会
- Data Source
  KAKENHI-PROJECT-17K15493
[Presentation] In vitro and in silico studies on PPARalpha/gamma and PXR activation by di-(2-ethylhexyl) phthalate and its metabolites.2018
- Author(s)
  Kojima H, Okuda K, Uramaru N, Kitamura S, Takeuchi S, Muromoto R, Sugihara K, Kishi R, Araki A.
- Organizer
  Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter (ISEE-ISES AC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] カルバメート系農薬のラットおよびヒトでのin vitro代謝とその核内受容体活性への影響2017
- Author(s)
  藤野智恵里、渡部容子、浦丸直人、佐能生剛、小島弘幸、吉成浩一、北村繁幸
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] Characterization of the endocrine disruption potential of bisphenol A structural analogues via human nuclear receptors.2017
- Author(s)
  Kojima H, Takeuchi S, Sanoh S, Kitamura S, Uramaru N, Sugihara K, Yoshinari K.
- Organizer
  The 14th International Symposium on Persistent Toxic Substances (ISPTS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] パラベン、サリチル酸エステル及びフタル酸エステルの核内受容体の構造活性相関2016
- Author(s)
  津越幸枝，谷川悠華，渡部容子，浦丸直人，小島弘幸，北村繁幸
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] パラベン、サリチル酸エステル及びフタル酸エステルの核内受容体活性の構造活性相関2016
- Author(s)
  津越幸枝、谷川悠華、渡部容子、浦丸直人、小島弘幸、北村繁幸
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市（パシフィコ横浜）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] 臭素化難燃剤のPBDEおよびその代謝物による肝UGT遺伝子発現への影響2016
- Author(s)
  清水　良，浦丸直人，渡部容子，太田　茂，北村繁幸，杉原数美
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] Comparative study on the in vitro nuclear receptor activities of di-(2-ethylhexyl) phthalate and its five metabolites.2016
- Author(s)
  Hiroyuki Kojima, Naoto Uramaru, Shigeyuki Kitamura, Shinji Takeuchi S, Reiko Kishi, Atsuko Araki
- Organizer
  Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter (ISEE-ISES AC 2016)
- Place of Presentation
  Sapporo (Japan)
- Year and Date
  2016-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] リン系難燃剤のラット肝カルボキシルエステラーゼ活性に対する阻害効果2015
- Author(s)
  渡部容子，井上智賀，谷川悠華，浦丸直人，杉原数美，小島弘幸，北村繁幸
- Organizer
  フォーラム2015 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] サリチル酸及びサリチル酸エステル類の核内受容体ER, AR, PXR及びCARに対する作用2015
- Author(s)
  谷川悠華、小山賢一、渡部容子、浦丸直人、小島弘幸、藤本成明、北村繁幸
- Organizer
  フォーラム2015衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸市（神戸学院大学ポートアイランドキャンパス）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] リン系難燃剤のラット肝カルボキシルエステラーゼ活性に対する阻害効果2015
- Author(s)
  渡部容子、井上智賀、谷川悠華、浦丸直人、杉原数美、小島弘幸、北村繁幸
- Organizer
  フォーラム2015衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸市（神戸学院大学ポートアイランドキャンパス）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] サリチル酸及びサリチル酸エステル類の核内受容体ER, AR, PXR及びCARに対する活性2015
- Author(s)
  谷川悠華，小山賢一，渡部容子，浦丸直人，小島弘幸，藤本成明，北村繁幸
- Organizer
  フォーラム2015 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 核内受容体の転写活性化を介した新規甲状腺ホルモンかく乱機構の解析2015
- Author(s)
  清水良、渡部容子、浦丸直人、小島弘幸、武内伸治、黒木広明、太田茂、北村繁幸、杉原数美
- Organizer
  フォーラム2015衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸市（神戸学院大学ポートアイランドキャンパス）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K08791
[Presentation] Influence of halogenated phenolic compounds on thyroid hormone system via inhibition of iodotyrosine deiodinase activity2014
- Author(s)
  R. Shimizu, M. Yamaguchi, N. Uramaru, H. Kuroki, S. Ohta, S. Kitamura , K. Sugihara
- Organizer
  53rd Annual Meeting and ToxExpo (Society of Toxicology)
- Place of Presentation
  Phoenix, Arizona, USA
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] Structure-activity relationships of a series of 17 parabens for histamine release in rat peritoneal mast cells, skin allergic reaction in guinea pigs, and hydrolytic activity in rat and guinea pig skin2013
- Author(s)
  N. Uramaru, T. Inoue, Y. Watanabe, S. Ohta S. Kitamura
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Tronto, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] 保存剤パラベン類のヒトおよびラット組織ミクロソームでの加水分解活性の構造代謝相関2013
- Author(s)
  渡部容子, 田中聡一, 藤野智恵里, 浦丸直人, 太田茂, 北村繁幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Reaction of fused (pyrimidin-4-yl)amidine derivatives with hydroxylamine hydrochloride: Formation of N-[2-([1,2,4]-oxadiazol-5-yl)aryl-1-yl]formamide oximes as inhibitors of advanced glycation end products2013
- Author(s)
  K. Okuda, N. Uramaru, K. Tsuchie, R. Ide, T. Hirota
- Organizer
  9th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びモルモット皮膚反応の構造活性相関の検討2013
- Author(s)
  浦丸直人ら
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びラットミクロソームにおける加水分解活性の構造活性相関の検討2013
- Author(s)
  浦丸直人ら
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] 穀物によるマウス肝薬物代謝酵素の変動2013
- Author(s)
  清水良, 山口雅史, 浦丸直人, 黒木広明, 北村繁幸, 太田茂, 杉原数美
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] ヒト・マウスにおけるアルデヒドオキシダーゼの代謝活性と基質特異性の比較2013
- Author(s)
  小原裕月, 佐能正剛, 杉原数美, 岸野貴大, 田山武崇, 浦丸直人, 立野知世, 北村繁幸, 太田茂
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びモルモット皮膚反応の構造活性相関の検討2013
- Author(s)
  浦丸直人ら
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] 保存剤パラベン類のラット肝および小腸ミクロソームでのエステル交換反応2013
- Author(s)
  藤野智恵里, 渡部容子, 浦丸直人, 北村繁幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びラットミクロソームにおける加水分解活性の構造活性相関の検討2013
- Author(s)
  浦丸直人ら
- Organizer
  フォーラム2013 衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 紫外線吸収剤ベンゾフェノン-3 のラットおよびヒトによる代謝とエストロゲンおよび抗アンドロゲン活性の変動2013
- Author(s)
  渡部容子, 小島弘幸, 武内伸治, 長本哲明, 浦丸直人, 太田茂, 北村繁幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びラットミクロソームにおける加水分解活性の構造活性相関の検討2013
- Author(s)
  浦丸直人ら
- Organizer
  フォーラム2012環境衛生・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] ラット肝ミクロソームによるベンゾフェノン系紫外線吸収剤の代謝とエストロゲン活性の変動2013
- Author(s)
  白鳥由衣, 渡部容子, 小島弘幸, 武内伸治, 江森千紘, 浦丸直人, 北村繁幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Structure-Activity Relationships of a Series of 17 Parabens for Histamine Release in Rat Peritoneal Mast Cells, Skin Allergic Reaction in Guinea Pigs, and Hydrolytic Activity in Rat and Guinea Pig Skin2013
- Author(s)
  Uramaru N. et al
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Tronto, Ontario, Canada.
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] パラベン類のラット肥満細胞におけるヒスタミン遊離作用及びモルモット皮膚反応の構造活性相関の検討2013
- Author(s)
  浦丸直人, 井上俊夫, 渡部容子, 太田茂, 北村繁幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] アルコール存在下におけるパラベン類の代謝2012
- Author(s)
  藤野智恵里, 田中聡一, 渡部容子, 浦丸直人, 北村繁幸
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] ラット肝ミクロソームによるベンゾフェノン系紫外線吸収剤の代謝2012
- Author(s)
  白鳥由衣, 渡邊麻友, 渡部容子, 浦丸直人, 北村繁幸
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] ラットにおける紫外線吸収剤ベンゾフェノン‐3 の in vivo‐in vitro 代謝の相関性2012
- Author(s)
  長本哲明, 山川亞以子, 中尾浩文, 渡部容子, 浦丸直人, 北村繁幸
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Metabolism of parabens by rat liver microsomes and its modification of the Endcrine disrupting activity2012
- Author(s)
  Uramaru N. et al
- Organizer
  SETAC Asia Pacific 2012
- Place of Presentation
  Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] 抗菌剤パラベン類の内分泌撹乱作用の特徴と構造活性相関2012
- Author(s)
  渡部容子, 小島弘幸, 武内伸治, 浦丸直人, 太田茂, 北村繁幸
- Organizer
  フォーラム 2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] セリ科生薬エキスのラット肝シトクロム P450 系への影響2012
- Author(s)
  荒井優子, 青木純一, 渡部容子, 浦丸直人, 山路誠一, 北村繁幸
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Metabolism of parabens by rat liver microsomes and its modification of the endocrine-disrupting activity.2012
- Author(s)
  Uramaru, N., Watanabe, Y.,. Kitamura, S.,Takeuchi S., Kojima H
- Organizer
  SETAC (The Society of Environmental Toxicology and Chemistry) Asia Pacific 2012 Meeting Abstract
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Metabolism of benzophenone-3, a sunscreen, by rat liver microsomes and modification of the endocrine-disrupting activity2012
- Author(s)
  Kitamura S., Watanabe Y., Uramaru N., Takeuchi S., Kojima H.
- Organizer
  SETAC (The Society of Environmental Toxicology and Chemistry) Asia Pacific 2012 Meeting Abstract
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] ヒト・マウス・ヒト肝キメラマウスにおけるアルデヒドオキシダーゼの酵素活性の比較2012
- Author(s)
  小原裕月, 佐能正剛, 杉原数美, 岸野貴大, 田山剛崇, 浦丸直人, 立野知世, 北村繁幸, 太田茂
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] カルボキシエステラーゼおよびシトクロム P450 が関与する抗菌剤パラベン類の代謝2012
- Author(s)
  田中聡一, 渡部容子, 浦丸直人, 北村繁幸
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] 環境科学物質による甲状腺ホルモン撹乱作用の in vitro および in vivo 評価2012
- Author(s)
  松原加奈, 中村直樹, 佐能正剛, 杉原数美, 浦丸直人, 北村繁幸, 宮川信一, 井口泰泉, 藤本成明, 太田茂
- Organizer
  フォーラム 2012 衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Metabolism of parabens by rat liver microsomes and its modification of the Endcrine disrupting activity,2012
- Author(s)
  Uramaru et al.
- Organizer
  SETAC Asia Pacific 2012
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Metabolism of parabens by rat liver microsomes and its modification of the Endcrine disrupting activity2012
- Author(s)
  Uramaru et al.
- Organizer
  SETAC Asia Pacific 2012
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-24790126
[Presentation] ブチルパラベンのアレルギー発症における代謝的活性化2011
- Author(s)
  浦丸直人, ら
- Organizer
  第131回日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] ブチルパラベンのアレルギー発症における代謝的活性化2011
- Author(s)
  浦丸直人, 他
- Organizer
  第131回日本薬学会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-22510071
[Presentation] Effects of metabolism of UV-absorbers by rat liver microsomes on their nuclear receptor activation.
- Author(s)
  Watanabe Y., Kojima H., Takeuchi S., Uramaru N., Sugihara K., Sanoh S., Ohta S., Kitamura S.
- Organizer
  DIOXIN 2014. The 34th International Symposium on Halogenated Persistent Organic Pollutants,
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] レポーターアッセイ系を用いた香粧品香料によるPXR、CAR、PPARおよびAhR活性の評価
- Author(s)
  渡部容子，小島弘幸，浦丸直人，藤本成明，杉原数美，吉成浩一，太田　茂，北村繁幸
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] ピレスロイド系およびカルバメート系農薬のラットPXR、CARおよびPPARa活性と肝代謝による影響
- Author(s)
  藤野智恵里，渡部容子，浦丸直人，小島弘幸，吉成浩一，北村繁幸
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 核内受容体PXRおよびCAR転写活性作用を示す甲状腺ホルモン構造類似環境化学物質のスクリーニング
- Author(s)
  清水　良，渡部容子，浦丸直人，小島弘幸，武内伸治, 黒木広明, 太田　茂, 北村繁幸, 杉数美
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] Comparative study on human and mouse nuclear receptor activities of hepatomegaly inducing perfluoroocatanoic acid and its related compounds.
- Author(s)
  Kojima H, Takeuchi S, Sata F, Nakajima H, Noomote T, Fujino C, Uramaru N, Kitamura S, Yoshinari K.
- Organizer
  International Conference of Asian Environmental Chemistry (ICAEC2014)
- Place of Presentation
  Bangkok
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] ラットin vivo及びin vitroでのラズベリーケトンのロドデノールへの還元
- Author(s)
  坂本佳澄，渡部容子，浦丸直人，北村繁幸
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] Metabolic activation of cis- and trans- permethrine for estrogenic and anti-androgenic activities
- Author(s)
  Sugihara K.,Tange N., Fujimoto N., Uramaru N., Ohta S., Kitamura S.
- Organizer
  DIOXIN 2014. The 34th International Symposium on Halogenated Persistent Organic Pollutants,
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 抗菌剤パラベン類のヒトおよびラットPXR、CAR、PPARa活性
- Author(s)
  藤野智恵里，渡部容子，浦丸直人，小島弘幸，吉成浩一，北村繁幸
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 香粧品香料のヒトおよびラットPXR、CAR、PPARa、AhRに対するアゴニスト活性
- Author(s)
  渡部容子，小島弘幸，浦丸直人，杉原数美, 吉成浩一, 太田　茂，北村繁幸．
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 核内受容体PXRおよびCAR転写活性に対する甲状腺ホルモン構造類似物質の影響
- Author(s)
  清水　良，渡部容子，浦丸直人，小島弘幸，武内伸治，黒木広明，太田　茂，北村繁幸，杉原数美
- Organizer
  フォーラム2014衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25340049
[Presentation] 化学物質の核内受容体活性化作用と肝肥大作用
- Author(s)
  小島弘幸，北村繁幸，浦丸直人，吉成浩一．
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25340049

1. KITAMURA Shigeyuki (40136057)

# of Collaborated Projects: 2 results

# of Collaborated Products: 43 results
2. FUJIMOTO Nariaki (40243612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. SUGIHARA Kazumi (20271067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
4. KOJIMA Hiroyuki (10414286)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
5. KASHIWAGI Akihiko (50106796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMIZU RYOU (00570491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Tishio Inoue (70458610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKEUCHI Shinji (20414287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. MAEDA TOMOJI (60303294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鈴木智宏 (10414327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 室本竜太 (30455597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 千葉健史 (80552926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 長部誠 (40700985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. 樋口敏幸 (50264289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
15. 村橋毅 (70340445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUGANO Youhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OKUDA Katsuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. SANOH Seigo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. SUZUKI Go

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 今岡進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 岡田和嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 太田茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 古武弥一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

uramaru naoto 浦丸 直人

Uramaru Naoto 浦丸 直人

URAMARU Naoto 浦丸 直人

Research Projects

Research Products

Co-Researchers

非アルコール性脂肪肝疾患を改善する植物由来成分の探索と予防改善薬創生への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Changes in expression/activity of Cytochrome P450 in simple fatty liver and steatohepatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of physiological roles of various physiologically active substances in breast milk

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Predictability of pathogenesis of allergic contact dermatitis based on specific chemical structure caused by metabolic activation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of chemical mixtures contained in foods on immune response via nuclear receptors.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Estimation of target proteins of hydroxylated PCB and brominated flame retardants for thyroid hormone disruption and the influence by radiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathogenesis of psoriasis using TRAF3IP/2Act 1 deficient mice and development of new therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The metabolic activation and the structural requirement in the allergic reactions of drugs and environmental chemicalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of targets for thyroid hormone disruption by brominated flame retardants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rhododendrol, a reductive metabolite of raspberry ketone, suppresses the differentiation of 3T3-L1 cells into adipocytes.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Carbonic anhydrase 3 increases during liver adipogenesis even in pre‐obesity, and its inhibitors reduce liver adipose accumulation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective Synthesis and Photoluminescence Study of Pyrazolopyridopyridazine Diones and N-Aminopyrazolopyrrolopyridine Diones2020

Author(s)

Journal Title

uramaru naoto 浦丸直人

Uramaru Naoto 浦丸直人

URAMARU Naoto 浦丸直人