Kitajima Shunsuke 北嶋俊輔

… Alternative Names

KITAJIMA Shunsuke 北嶋俊輔

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Researcher Number	90566465
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がんプレシジョン医療研究センターがん免疫制御プロジェクト, プロジェクトリーダー
Affiliation (based on the past Project Information) *help	2025: 公益財団法人がん研究会, がんプレシジョン医療研究センターがん免疫制御プロジェクト, プロジェクトリーダー 2020 – 2024: 公益財団法人がん研究会, がん研究所細胞生物部, 研究員 2016: 金沢大学, がん進展制御研究所, 特任助教 2015: 金沢大学, がん進展制御研究所, 教授 2012 – 2014: 金沢大学, がん進展制御研究所, 特任助教 2012: 金沢大学, がん進展制御研究所, 博士研究員 2011: 金沢大学, がん進展制御研究所, 研究員
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Transformative Research Areas, Section (III) / Tumor biology / Tumor biology Except Principal Investigator Tumor biology
Keywords	Principal Investigator KRAS / 非小細胞肺がん / STING / Rb / 染色体不分離 / MAVS経路 / STING経路 / dsRNA / STK11/LKB1 / cGAS-STING経路 … More / オートファジー / リン酸化 / 新規リン酸化 / cGAS / LKB1 / STK11 / STINGアゴニスト / cGAMP / Breast cancer / IL-6 / Tumor microenvironment / CCR2 / CCL2 / RB / Trp53 / Inflammation / Cancer stem cell / p53 … More Except Principal Investigator 代謝 / RB / がん / グルタミン / 糖代謝 / コレステロール / がん幹細胞 / がん抑制遺伝子 / PGAM / 脂質代謝 / 解糖系 / がん代謝 / 微小環境 / 乳がん / ケモカイン / サイトカイン / IL-6 / 炎症 Less

染色体不分離に伴う免疫原性核酸の発生機構解明およびがん治療への応用Principal Investigator
- Principal Investigator
  
  北嶋俊輔
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Japanese Foundation for Cancer Research
Identification of non-coding genomic regions producing immunogenic non-coding RNAPrincipal Investigator
- Principal Investigator
  
  北嶋俊輔
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
KRAS-LKB1変異型肺がんに特徴的な免疫抑制性のがん微小環境形成機構の解明Principal Investigator
- Principal Investigator
  
  北嶋俊輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Dynamics of micronuclei regulated by the cytosolic DNA sensor cGASPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Shunsuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Identification of STING agonist transporter in cancer cells by utilizing a lineage barcoding systemPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Shunsuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Overcoming resistance to immune checkpoint inhibitors in KRAS-LKB1 mutant lung cancer.Principal Investigator
- Principal Investigator
  
  KITAJIMA Shunsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Inflammatory circuit that triggres malignant progression
- Principal Investigator
  
  Takahashi Chiaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Regulation of metabolism by RB tumor suppressor gene
- Principal Investigator
  
  Takahashi Chiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
CCL2 induced by RB inactivation contributes to the formation of tumor-promoting inflammatory microenvironmentPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Shunsuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Undifferentiated state induced by Rb inactivation associated with activation of inflammatory signalingPrincipal Investigator
- Principal Investigator
  
  KITAJIMA Shunsuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 『代謝変化とエピジェテックス制御』「RBがん抑制遺伝子産物による細胞未分化性制御」2016
- Author(s)
  河野晋、北嶋俊輔、佐々木信成、髙橋智聡.
- Total Pages
  7
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-26290037
[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー第35回」2015
- Author(s)
  北嶋俊輔, 河野晋, 髙橋智聡
- Publisher
  BioMedサーカス.com
- Data Source
  KAKENHI-PROJECT-26640070
[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー第35回」2015
- Author(s)
  北嶋俊輔, 河野晋, 髙橋智聡
- Publisher
  BioMedサーカス.com
- Data Source
  KAKENHI-PROJECT-26290037
[Book] 「インビトロ幹細胞モデル」『実験医学増刊　がん幹細胞　―ステムネス、ニッチ、標的細胞への理解―』2011
- Author(s)
  北嶋俊輔、高橋智聡
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23701048
[Journal Article] <i>TREX1</i> Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity2024
- Author(s)
  Tani Tetsuo、Mathsyaraja Haritha、Campisi Marco、Li Ze-Hua、Haratani Koji、Fahey Caroline G.、Ota Keiichi、Mahadevan Navin R.、Shi Yingxiao、Saito Shin、Mizuno Kei、Thai Tran C.、Sasaki Nobunari、Homme Mizuki、・・・・・・・・Liu David、Uppaluri Ravindra、Kitajima Shunsuke、Cain Jennifer、Barbie David A, et al
- Journal Title
  
  Cancer Discovery
  
  Volume: 14 Issue: 5 Pages: 752-765
- DOI
  10.1158/2159-8290.cd-23-0700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06684, KAKENHI-PROJECT-23K27444
[Journal Article] Targeting the loss of <scp>cGAS</scp>/<scp>STING</scp> signaling in cancer2023
- Author(s)
  Sasaki Nobunari、Homme Mizuki、Kitajima Shunsuke
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 10 Pages: 3806-3815
- DOI
  10.1111/cas.15913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06684, KAKENHI-PROJECT-22K19467, KAKENHI-PROJECT-23K27444
[Journal Article] MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer2022
- Author(s)
  Kitajima Shunsuke、Tani Tetsuo、Springer Benjamin F.、Campisi Marco、Osaki Tatsuya、Haratani Koji、Chen Minyue、Knelson Erik H.、Mahadevan Navin R.、Ritter Jessica、Yoshida Ryohei、Kohler Jens、Ogino Atsuko、Nozawa Ryu-Suke、他14名
- Journal Title
  
  Cancer Cell
  
  Volume: 40 Issue: 10 Pages: 1128-1144
- DOI
  10.1016/j.ccell.2022.08.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19465, KAKENHI-PUBLICLY-22H05608, KAKENHI-PROJECT-20H03190, KAKENHI-PROJECT-20H03521
[Journal Article] KRAS G12C inhibition and innate immune targeting2021
- Author(s)
  T.Tani, S.Kitajima, EB.Conway, EH.Knelson, and DA. Barbie
- Journal Title
  
  Expert Opinion on Therapeutic Targets
  
  Volume: - Issue: 3 Pages: 167-174
- DOI
  10.1080/14728222.2021.1902991
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03521
[Journal Article] Tumor-Derived cGAMP Regulates Activation of the Vasculature2020
- Author(s)
  Campisi Marco, Sundararaman Shriram K.、Shelton Sarah E., Ryohei,Tani Tetsuo、Ivanova Elena, Osaki Tatsuya, Lee Sharon Wei Ling, Thai Tran, Han Saemi、Piel Brandon P., Gilhooley Sean, Paweletz Cloud P.,Chiono Valeria、Kamm Roger D., Kitajima Shunsuke、Barbie David A.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 2090-2090
- DOI
  10.3389/fimmu.2020.02090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20178, KAKENHI-PROJECT-20H03521
[Journal Article] MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.2017
- Author(s)
  Yoshida A, Kitajima S, Li F, Chaoyang C, Yujiro T, Susumu K, Wan Y, Naoyuki H, Hayato M, Nishimoto Y, Nagatani N, Nishiuchi T, Thai T C, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie D A and Takahashi C.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Issue: 8 Pages: 13872-85
- DOI
  10.18632/oncotarget.14681
- NAID
  120006226780
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-26430105, KAKENHI-PROJECT-16KK0197, KAKENHI-PROJECT-17K19586, KAKENHI-PROJECT-17K14992, KAKENHI-PUBLICLY-17H05615, KAKENHI-PROJECT-17H03576
[Journal Article] The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.2017
- Author(s)
  Kitajima S, Yoshida A, Susumu K, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Hayato M, Wan Y, Thai T C, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M E, Barbie D A, Hirose O, Tanaka T and Takahashi C
- Journal Title
  
  Oncogene
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Journal Article] RB tumor suppressor functions shared by stem cell and cancer cell strategies.2016
- Author(s)
  Kohno S, Kitajima S, Sasaki N and Takahashi C.
- Journal Title
  
  World J Stem Cells
  
  Volume: 8 Issue: 4 Pages: 170-184
- DOI
  10.4252/wjsc.v8.i4.170
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-15K18404
[Journal Article] Undifferentiated State Induced by Rb-P53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts2015
- Author(s)
  Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, Mohammed MS, Muranaka H, Nagatani N, Suzuki M, Kido Y, Takahashi C
- Journal Title
  
  STEM CELLS
  
  Volume: - Issue: 5 Pages: 1657-1669
- DOI
  10.1002/stem.1971
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25830076, KAKENHI-PROJECT-25830077, KAKENHI-PROJECT-26640070, KAKENHI-PROJECT-15K18404, KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26290037
[Journal Article] An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal.2015
- Author(s)
  Salah M, Nishimoto Y, Kohno S, Kondoh A, Kitajima S, Muranaka H, Nishiuchi T, Ibrahim A, Yoshida A, Takahashi C.
- Journal Title
  
  Mol Carcinog.
  
  Volume: in press Issue: 12 Pages: 1974-1989
- DOI
  10.1002/mc.22444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18404, KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26640070, KAKENHI-PROJECT-26290037
[Journal Article] Primary Culture of Mouse Thyroid Calcitonin-producing Cell (C cell) Tumors.2015
- Author(s)
  Kitajima S, Li F, Takahashi C.
- Journal Title
  
  Bio-Protocol
  
  Volume: 5-24
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290037
[Journal Article] RB tumor suppressor functions shared by stem cell and cancer cell strategies.2015
- Author(s)
  Kohno S, Kitajima S, Sasaki N and Takahashi C.
- Journal Title
  
  World J Stem Cells
  
  Volume: 8 Pages: 170-184
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640070
[Journal Article] Primary Culture of Mouse Thyroid Calcitonin-producing Cell (C cell) Tumors.2015
- Author(s)
  Kitajima S, Li F, Takahashi C.
- Journal Title
  
  Bio-Protocol
  
  Volume: 5-24
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640070
[Journal Article] Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations.2015
- Author(s)
  Okahashi N, Kohno S, Kitajima S, Matsuda F, Takahashi C, Shimizu H.
- Journal Title
  
  J Biosci Bioeng.
  
  Volume: 120 Issue: 6 Pages: 725-731
- DOI
  10.1016/j.jbiosc.2015.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18404, KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-15J05988, KAKENHI-PROJECT-26640070, KAKENHI-PROJECT-26290037
[Journal Article] ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.2013
- Author(s)
  Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33 Issue: 16 Pages: 3113-3124
- DOI
  10.1128/mcb.01597-12
- NAID
  120005312327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25340028, KAKENHI-PROJECT-25830076, KAKENHI-PROJECT-25830077
[Journal Article] Twists in views on RB functions in cellular signaling, metabolism and stem cells.2012
- Author(s)
  Chiaki Takahashi
- Journal Title
  
  Cancer Science
  
  Volume: Volume103, Issue7 Issue: 7 Pages: 1182-1188
- DOI
  10.1111/j.1349-7006.2012.02284.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701048
[Journal Article] Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells2012
- Author(s)
  Taura M., et.al.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 32(8) Issue: 8 Pages: 1581-1590
- DOI
  10.1128/mcb.06454-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-22390015, KAKENHI-PROJECT-22390055, KAKENHI-PROJECT-23590082, KAKENHI-PROJECT-23701048, KAKENHI-PUBLICLY-23107725, KAKENHI-PLANNED-23116009
[Presentation] シンジェニックマウスモデルを用いたKRAS-STK11変異型肺がんに特徴的な免疫抑制性微小環境の解析2023
- Author(s)
  北嶋　俊輔
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27444
[Presentation] Priming the immunogenicity of KRAS-LKB1 mutant lung cancer through STING activation2023
- Author(s)
  北嶋　俊輔
- Organizer
  第８２回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19467
[Presentation] Priming the immunogenicity of KRAS-LKB1 mutant lung cancer through STING activation2023
- Author(s)
  北嶋　俊輔
- Organizer
  第61回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27444
[Presentation] Priming the immunogenicity of KRAS-LKB1 mutant lung cancer through STING activation2023
- Author(s)
  北嶋　俊輔
- Organizer
  第８２回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27444
[Presentation] シンジェニックマウスモデルを用いたKRAS-STK11変異型肺がんに特徴的な免疫抑制性微小環境の解析2023
- Author(s)
  北嶋　俊輔
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19467
[Presentation] Priming the immunogenicity of KRAS-LKB1 mutant lung cancer through STING activation2023
- Author(s)
  北嶋　俊輔
- Organizer
  第61回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19467
[Presentation] MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer2022
- Author(s)
  北嶋俊輔
- Organizer
  第８１回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03521
[Presentation] 2.紡錘体チェックポイントキナーゼMPS1によるSTING経路の制御機構解明とがん免疫療法への応用2021
- Author(s)
  北嶋俊輔
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03521
[Presentation] 1.Novel strategy for priming immunogenicity of KRAS;LKB1 mutant lung cancer through MPS1 inhibition2021
- Author(s)
  北嶋俊輔
- Organizer
  第62回日本肺癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03521
[Presentation] 1.Novel strategy for priming immunogenicity of KRAS;LKB1 mutant lung cancer through MPS1 inhibition2021
- Author(s)
  北嶋俊輔
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03521
[Presentation] MPS1阻害剤を用いたKRAS/LKB1変異型肺がんが示す免疫チェックポイント阻害薬2020
- Author(s)
  北嶋俊輔
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03521
[Presentation] Metabolic rewiring in Rb deficient cells during cancer progression.2016
- Author(s)
  Kohno S, Okahashi N, Kitajima S Suzuki S, Tanaka T, Matsuda F, Shimizu H and Takahashi C.
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans USA/Ernest N. Morial Convention Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RBがん抑制遺伝子による代謝制御と細胞未分化性2016
- Author(s)
  髙橋智聡, 北嶋俊輔, 河野晋
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都/京都テルサ
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2016
- Author(s)
  Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H and Takahashi C
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Canada/Fairmont Banff Springs
- Year and Date
  2016-02-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640070
[Presentation] RB function in controlling glycolysis.2016
- Author(s)
  Kohno S, Kitajima S and Takahashi C.
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Canada/Fairmont Banff Springs
- Year and Date
  2016-02-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640070
[Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2016
- Author(s)
  Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H and Takahashi C
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Canada/Fairmont Banff Springs
- Year and Date
  2016-02-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] The Metabolic Bases for Inflammatory Phenotype Associated with RB-deficiency in Mammary Cells.2016
- Author(s)
  Nishimoto Y, Kitajima S and Takahashi C
- Organizer
  Fourth International Rb Meeting
- Place of Presentation
  Hilton Columbus Downtown /コロンバス　オハイオ州
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RB function in controlling glycolysis.2016
- Author(s)
  Kohno S, Kitajima S and Takahashi C.
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Canada/Fairmont Banff Springs
- Year and Date
  2016-02-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2015
- Author(s)
  Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H, Takahashi C.
- Organizer
  Cancer and Metabolism conference
- Place of Presentation
  英国　Cambridge/Robinson College
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2015
- Author(s)
  Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H, Takahashi C.
- Organizer
  Cancer and Metabolism conference
- Place of Presentation
  英国 Cambridge/Robinson College
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640070
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression2015
- Author(s)
  Sasaki N, Kitajima S, Muranaka H, Shamma A, Kohno S, Takahashi C
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver・Canada・Fairmont Hotel
- Year and Date
  2015-01-16
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression.2014
- Author(s)
  Sasaki N, Muranaka H, Kitajima S, Kohno S, Shamma A and Takahashi C
- Organizer
  第37回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構.2014
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RBの中心代謝制御機能2014
- Author(s)
  河野晋, 北嶋俊輔, 吉田晶代, 鈴木佐和子, 田中知明, 佐々木信成, 村中勇人, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Undifferentiated state induced by Rb inactivation associated with enhanced inflammatory signaling2014
- Author(s)
  Shunsuke Kitajima, Sawako Suzuki, Tomoaki Tanaka, Noriko Gotoh, Chiaki Takahashi
- Organizer
  International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] Rbによるサイトカインを介したがん悪性化制御機構の解明2014
- Author(s)
  北嶋俊輔, 吉田晶代, 河野晋, 鈴木佐和子, 田中知明, 後藤典子, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] マウス由来腫瘍細胞のRb1 不活性化シグニチャーとヒト乳癌の臨床像との関連2014
- Author(s)
  吉田晶代, 北嶋俊輔, 廣瀬修, 田中知明, 髙橋智聡
- Organizer
  第12回日本臨床腫瘍学会学術集会
- Place of Presentation
  福岡県・福岡市・福岡国際会議場
- Year and Date
  2014-07-17
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Undifferentiated state induced by Rb inactivation associated with enhanced inflammatory signaling2014
- Author(s)
  北嶋俊輔、高橋智聡
- Organizer
  がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] IL-6-dependent inflammatory phenotype induced by RB inactivation sustains self-renewal and drug resistance.2014
- Author(s)
  Kitajima S, and Takahashi C
- Organizer
  がん微小環境に関する国際シンポジウム
- Place of Presentation
  石川県・金沢市・金沢大学
- Year and Date
  2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26640070
[Presentation] RBによるサイトカインを介したがん悪性化制御機構の解明2014
- Author(s)
  北嶋俊輔, 吉田晶代, 河野晋, 鈴木佐和子, 田中知明, 後藤典子, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] In vitro乳腺発がんモデルにおけるがん抑制遺伝子Rb, p53の機能とその作用機構の解析2014
- Author(s)
  西本裕希, Mohammed M, 吉田晶代, 西内巧, 北嶋俊輔, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析2014
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 吉田晶代, 丹下正一朗, 鈴木健之, 林昭夫, 多田秀昭, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RB不活性化によって誘導されるがん幹細胞様未分化状態におけるPgam2の役割2014
- Author(s)
  河野晋, 北嶋俊輔, 佐々木信成, 村中勇人, 鈴木佐和子, 田中知明, 岡橋伸幸, 松田史生, 清水浩, 髙橋智聡
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京都・葛飾区・東京理科大学
- Year and Date
  2014-07-16
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] マウスにおいてRb1はmiR-140を介して腫瘍抑制的に作用する2014
- Author(s)
  吉田晶代, 北嶋俊輔, 林直之, 広瀬修, 髙橋智聡.マウスにおいてRb1はmiR-140を介して腫瘍抑制的に作用する
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] がん幹細胞仮説とがん化シグナル2014
- Author(s)
  北嶋俊輔
- Organizer
  日本生化学会北陸支部第３２回大会
- Place of Presentation
  富山
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] IL-6-dependent inflammatory phenotype induced by RB inactivation sustains self-renewal and drug resistance2014
- Author(s)
  Kitajima, S. and Takahashi, C.
- Organizer
  International Symposium on Tumor Microenvironment-Crosstalk between host and malignant cells
- Place of Presentation
  金沢
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] Rbによるサイトカインを介したがん悪性化制御機構の解明2014
- Author(s)
  北嶋俊輔, 吉田晶代, 河野晋, 鈴木佐和子, 田中知明, 後藤典子, 髙橋智聡
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26640070
[Presentation] Undifferentiated state induced by Rb inactivation associated with enhanced inflammatory signaling2013
- Author(s)
  Shunsuke Kitajima, Akiyo Yoshida, Sawako Suzuki, Tomoaki Tanaka, Noriko Gotoh, Chiaki Takahashi
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013
- Author(s)
  Kitajima,S.,Takahashi,C.
- Organizer
  The 3rd International Symposium on Carcinogenic Spiral and Internatinal Symposium on Tumor Biology in Kanazawa
- Place of Presentation
  金沢エクセルホテル東急 (石川県)
- Year and Date
  2013-01-25
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013
- Author(s)
  Kitajima,S.,Takahashi,C.
- Organizer
  9thAACR/JCA Joint Conference
- Place of Presentation
  Hyatt Regency Maui (USA)
- Year and Date
  2013-02-22
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with activation of inflammatory signaling2013
- Author(s)
  北嶋俊輔、鈴木佐和子、田中知明、高橋智聡
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25830077
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2013
- Author(s)
  北嶋俊輔,高橋智聡
- Organizer
  平成24年度個体レベルでのがん研究支援活動ワークショップ
- Place of Presentation
  琵琶湖ホテル(滋賀県)
- Year and Date
  2013-02-26
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiatedstate induced by Rb inactivation associated with metabolic reprogramming and inflammation2013
- Author(s)
  北嶋俊輔,高橋智聡
- Organizer
  平成24年度がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  学術総合センター一橋講堂(東京都)
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation2012
- Author(s)
  北嶋俊輔,高橋智聡
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] The RB-SREBP nexus where RB meets cell signaling and lipid metabolism.2012
- Author(s)
  S.Kitajima, Y.Kido, H.Muranaka, N.Sasaki, S.Kohno, C.Takahashi
- Organizer
  Keystone Symposia -Cancer and Metabolism-
- Place of Presentation
  Fairmont Banff Springs (Canada)
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation2012
- Author(s)
  北嶋俊輔,高橋智聡
- Organizer
  35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation2012
- Author(s)
  Kitajima,S.,Takahashi,C.
- Organizer
  The 7th International Symposium of the Institute Network
- Place of Presentation
  東北大学加齢医学研究所(宮城県)
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] The Rb-lipid signaling axis revealed by Rb composite knockout mouse studies.2011
- Author(s)
  S.Kitajima, Y.Kido, H.Muranaka, N.Sasaki, S.Kohno, C.Takahashi.
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川)
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] The RB-SREBP nexus where RB meets cell signaling and lipid metabolism.2011
- Author(s)
  S.Kitajima, C.Takahashi
- Organizer
  Second International Rb Meeting
- Place of Presentation
  Chestnut Conference Centre (Canada)
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation
- Author(s)
  Shunsuke Kitajima
- Organizer
  平成２４年度個体レベルでのがん研究支援活動ワークショップ
- Place of Presentation
  琵琶湖ホテル
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation
- Author(s)
  Shunsuke Kitajima
- Organizer
  9th AACR/JCA Joint Conference
- Place of Presentation
  Hyatt Regency Maui (USA)
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation
- Author(s)
  Shunsuke Kitajima
- Organizer
  The 3rd International Symposium on Carcinogenic Spiral and Internatinal Symposium on Tumor Biology in Kanazawa
- Place of Presentation
  金沢エクセルホテル東急
- Invited
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation
- Author(s)
  Shunsuke Kitajima
- Organizer
  平成２４年度がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  学術総合センター一橋講堂
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation
- Author(s)
  Shunsuke Kitajima
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated cancer stem cell-like phenotypes induced by Rb-p53 inactivation
- Author(s)
  Shunsuke Kitajima
- Organizer
  The 7th International Symposium of the Institute Network
- Place of Presentation
  東北大学加齢医学研究所
- Data Source
  KAKENHI-PROJECT-23701048
[Presentation] Undifferentiated state induced by Rb inactivation associated with metabolic reprogramming and inflammation
- Author(s)
  Shunsuke Kitajima
- Organizer
  第３５回日本分子生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23701048

1. Takahashi Chiaki (50283619)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. Hayashi Naoyuki (50253456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. Shamma Awad (50402839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Kohno Susumu (30625463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
5. Sasaki Nobunari (40415170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 日野原邦彦 (50549467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 野澤竜介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小林昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitajima Shunsuke 北嶋 俊輔

KITAJIMA Shunsuke 北嶋 俊輔

Research Projects

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Co-Researchers

染色体不分離に伴う免疫原性核酸の発生機構解明およびがん治療への応用Principal Investigator

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Identification of non-coding genomic regions producing immunogenic non-coding RNAPrincipal Investigator

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KRAS-LKB1変異型肺がんに特徴的な免疫抑制性のがん微小環境形成機構の解明Principal Investigator

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Dynamics of micronuclei regulated by the cytosolic DNA sensor cGASPrincipal Investigator

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Identification of STING agonist transporter in cancer cells by utilizing a lineage barcoding systemPrincipal Investigator

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Overcoming resistance to immune checkpoint inhibitors in KRAS-LKB1 mutant lung cancer.Principal Investigator

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Inflammatory circuit that triggres malignant progression

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Regulation of metabolism by RB tumor suppressor gene

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CCL2 induced by RB inactivation contributes to the formation of tumor-promoting inflammatory microenvironmentPrincipal Investigator

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Undifferentiated state induced by Rb inactivation associated with activation of inflammatory signalingPrincipal Investigator

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[Book] 『代謝変化とエピジェテックス制御』「RBがん抑制遺伝子産物による細胞未分化性制御」2016

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[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー 第35回」2015

Author(s)

Publisher

Data Source

[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー 第35回」2015

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[Book] 「インビトロ幹細胞モデル」『実験医学増刊 がん幹細胞 ―ステムネス、ニッチ、標的細胞への理解―』2011

Author(s)

Kitajima Shunsuke 北嶋俊輔

KITAJIMA Shunsuke 北嶋俊輔

[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー第35回」2015

[Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー第35回」2015

[Book] 「インビトロ幹細胞モデル」『実験医学増刊　がん幹細胞　―ステムネス、ニッチ、標的細胞への理解―』2011