NAKAHARA Mayumi 中原真由美

… Alternative Names

Nakahara Mayumi 中原真由美

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Researcher Number	90707514
External Links
Affiliation (Current)	2025: 鹿児島大学, 医歯学域医学系, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 鹿児島大学, 医歯学域医学系, 講師 2019 – 2020: 鹿児島大学, 医歯学域医学系, 助教 2015 – 2017: 鹿児島大学, 医歯学域医学系, 助教 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教 2013 – 2014: 鹿児島大学, 大学院医歯学総合研究科, 特任助教 2012: 鹿児島大学医学部, 歯学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 55050:Anesthesiology-related / Anesthesiology Except Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related
Keywords	Principal Investigator 神経活動イメージング / 敗血症関連脳症 / 麻酔 / 鎮静薬 / 神経イメージング / 敗血症性脳症 / 敗血症 / 炎症 / 蘇生後脳症 / 虚血再灌流 … More / 虚血再灌流傷害 / 細胞外ヒストン / ヒストン / 虚血再灌流障害 … More Except Principal Investigator 敗血症 / DAMPs / 細胞外ヒストン / トロンボモジュリン / ヒストン / 炎症 / DAMPｓ / 集中治療医学 / ペプチド / αヘリックス / 治療ターゲット / 炎症性サイトカイン / 抑制ペプチド / 敗血症治療 / 集中治療 / コンドロイチン硫酸 / 播種性血管内凝固症候群 / PAMPｓ / DAMP / PAMPs / 細胞・組織 / 感染症 / 血栓性微小血管障害症 / von Willebrand因子 / 血管内皮細胞 / 血栓症 / 病理学 / 免疫学 / 血栓 / DIC / ショック / HMGB1 / バソプレシン / 敗血症性ショック Less

敗血症脳症に伴う特異的脳神経活動の機能的意義Principal Investigator
- Principal Investigator
  
  中原真由美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Development of peptides that regulate DAMPs and their application deployment.
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
インビボ神経イメージングによる敗血症関連脳症に関与する大脳神経回路同定と治療戦略Principal Investigator
- Principal Investigator
  
  中原真由美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Neuroprotective effects of sedative drugs in post-resuscitation encephalopathy using in vivo neuroactivity imagingPrincipal Investigator
- Principal Investigator
  
  Nakahara Mayumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kagoshima University
Therapeutic strategy targeting extracellular histones in sepsis-associated DIC
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
evaluation of organ protective effects of anesthetic agents using extra-cellular histone modification in liver ischemia-reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  Nakahara Mayumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Kagoshima University
Extracellular histones as a myocardial depressant factor
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
HMGB1-induced vaspressin deficiency contributes to septic shock
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
A role of extracellular histones as mediators of death in sepsis
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University

All 2021 2020 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Non-invasive Monitoring of Hepatic Oxygenation Using Time-Resolved Spectroscopy.2016
- Author(s)
  Tomotsugu Yasuda, Keiji Yamaguchi, Takahiro Futatsuki, Hiroaki Furubeppu, 　　Mayumi Nakahara, Tomohiro Eguchi, Shotaro Miyamoto, Yutaro Madokoro, Shinsaku Terada, 　Kentaro Nakamura, Hiroki Harada, Taniguchi Junichiro, Kosuke Yanagimoto, Yasuyuki Kakihana
- Journal Title
  
  Oxygen Transport to Tissuue XXXVI
  
  Volume: 876 Pages: 407-412
- DOI
  10.1007/978-1-4939-3023-4_51
- ISBN
  9781493930227, 9781493930234
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861235, KAKENHI-PROJECT-25462443
[Journal Article] Sepsis-induced myocardial dysfunction: pathophysiology and management2016
- Author(s)
  Yasuyuki Kakihana, Takashi Ito, Mayumi Nakahara, Keiji Yamaguchi1 and Tomotsugu 　 Yasuda
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 4:22 Issue: 1 Pages: 1-10
- DOI
  10.1186/s40560-016-0148-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861235, KAKENHI-PROJECT-15H05684
[Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism2013
- Author(s)
  Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
- Journal Title
  
  PLoS One
  
  Volume: 8(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670763
[Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.2013
- Author(s)
  Nakahara M, Ito T, et al.
- Journal Title
  
  PLoS One
  
  Volume: 8(9) Issue: 9 Pages: 75961-75961
- DOI
  10.1371/journal.pone.0075961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659700, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-25670764
[Presentation] 術後認知機能障害(POCD)マウスモデルの開発と術後認知機能障害関連脳領域の同定2021
- Author(s)
  大江将軍、長谷川麻衣子、向原桂香、中原真由美、城山優治、奥野浩行、森山孝宏、上村裕一
- Organizer
  第62回日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-21K09077
[Presentation] 術後認知機能障害 (POCD) マウスモデルの開発と術後認知機能障害関連脳領域の同定2021
- Author(s)
  大江将軍、中原真由美、向原桂香、城山優治、奥野浩行、上村裕一
- Organizer
  第68回日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-19K18299
[Presentation] 術後認知機能障害に関与する大脳神経回路同定の試み2020
- Author(s)
  中原真由美、向原桂香、大江将軍、城山優治、奥野浩行、上村裕一
- Organizer
  第47回日本集中治療医学会
- Data Source
  KAKENHI-PROJECT-19K18299
[Presentation] マウスにおける全身麻酔下手術による扁桃体の神経活動亢進と記憶障害2020
- Author(s)
  城山優治、中原真由美、大江将軍、坂口茜、上村裕一、奥野浩行
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K18299
[Presentation] 小児心臓手術におけるHES130製剤使用による血液製剤使用量の変化2016
- Author(s)
  西藤智照、児玉健士、中原真由美、青木利奈、長谷川麻衣子、上村裕一
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  マリンメッセ福岡（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] The successful venoarterial extracorporeal membrane oxygenation tretment in a child with repetitive fulminant myocarditis2016
- Author(s)
  Y. Madokoro, T. Yasuda, S. Miyamoto, S. Terada, H. Haraura, M. Arima, T. Ito, M. Nakahara, T. Futatsuki, J. Taniguchi, K. Yanagimoto, K. Yamaguchi, Y. Kakihana
- Organizer
  8th World Congress on Pediatric Intensive and Critical Care
- Place of Presentation
  Metro Toronto Convention Centre (Toronto, Canada)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] プロポファールによる脂肪酸代謝抑制に対する糖・アミノ酸代謝の反応2016
- Author(s)
  森山孝宏、原田浩輝、中原真由美、松永明、上村裕一
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2016-02-14
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] 修正大血管転移症に対する三尖弁置換術後に中心静脈圧上昇を伴わない心タンポナーデを認めた一例2016
- Author(s)
  長嶺嘉通、原田浩輝、岩川昌平、中原真由美、長谷川麻衣子、安田智嗣、垣花泰之、上村裕一
- Organizer
  修正大血管転移症に対する三尖弁置換術後に中心静脈圧上昇を伴わない心タンポナーデを認めた一例
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2016-02-12
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] 敗血症において細胞外ヒストンは主に好中球に由来する2016
- Author(s)
  中原真由美、伊藤隆史、安田智嗣、垣花泰之、丸山征郎、上村裕一
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  マリンメッセ福岡（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] 38歳女性で腹腔鏡下子宮筋腫核出術後に急性心不全をきたし、心エコー検査で重症僧帽弁狭窄症が判明した一例2015
- Author(s)
  長嶺嘉通、原田浩輝、大納哲也、中原真由美、國吉保、松永明
- Organizer
  日本麻酔科学会九州麻酔科学会第53回大会
- Place of Presentation
  鹿児島サンロイヤルホテル（鹿児島県鹿児島市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] Massive thrombosis evoked by extracellular histones : Is it DIC?2013
- Author(s)
  Takashi Ito, Mayumi Nakahara, and Ikuro Maruyama
- Organizer
  59th Scientific and Standardization Committee Meeting of the ISTH 2013
- Place of Presentation
  オランダ.
- Data Source
  KAKENHI-PROJECT-25670763
[Presentation] 糖尿病患者における術中糖質投与による脂肪・蛋白異化抑制効果の検討
- Author(s)
  中原真由美、齋藤貴幸、原田那津美、五代幸平、長谷川麻衣子、上村裕一
- Organizer
  日本麻酔科学会第61回学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] Non-invasive monitoring of hepatic oxygenation using time-resolved spectroscopy
- Author(s)
  T.Yasuda, Y. Kakiahna, K. Yamaguchi, M. Nakahara, A. Hirakawa, J. Taniguchi, K. Nakamura, T. Futatsuki, 　 N. Oakayama
- Organizer
  International Society on Oxygen Transport to Tissue
- Place of Presentation
  ロンドン大学（イギリス・ロンドン）
- Year and Date
  2014-06-28 – 2014-07-03
- Data Source
  KAKENHI-PROJECT-26861235

1. ITO Takashi (20381171)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
2. KAWAHARA Ko-ichi (10381170)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
3. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. NAGASATO Tomoka

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
5. YAMADA Shingo

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. 城山優治 (90456195)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. MATSUMOTO Masanori (60316081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAYAKAWA Masaki (30516729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAKIHANA Yasuyuki (20264426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. YASUDA Tomotsugu (80437954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 升田好樹 (10244328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 寺崎寛人 (20746888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 三浦直樹 (80508036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 菊池清志 (60404539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 新山修平 (40258455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 奥野浩行 (80272417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. TAKENAKA Yukari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAHARA Mayumi 中原 真由美

Nakahara Mayumi 中原 真由美

Research Projects

Research Products

Co-Researchers

敗血症脳症に伴う特異的脳神経活動の機能的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of peptides that regulate DAMPs and their application deployment.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インビボ神経イメージングによる敗血症関連脳症に関与する大脳神経回路同定と治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuroprotective effects of sedative drugs in post-resuscitation encephalopathy using in vivo neuroactivity imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic strategy targeting extracellular histones in sepsis-associated DIC

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

evaluation of organ protective effects of anesthetic agents using extra-cellular histone modification in liver ischemia-reperfusion injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Extracellular histones as a myocardial depressant factor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HMGB1-induced vaspressin deficiency contributes to septic shock

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of extracellular histones as mediators of death in sepsis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Non-invasive Monitoring of Hepatic Oxygenation Using Time-Resolved Spectroscopy.2016

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Sepsis-induced myocardial dysfunction: pathophysiology and management2016

Author(s)

Journal Title

NAKAHARA Mayumi 中原真由美

Nakahara Mayumi 中原真由美

[Presentation] 術後認知機能障害 (POCD) マウスモデルの開発と術後認知機能障害関連脳領域の同定2021

[Presentation] 修正大血管転移症に対する三尖弁置換術後に中心静脈圧上昇を伴わない心タンポナーデを認めた一例2016

[Presentation] 38歳女性で腹腔鏡下子宮筋腫核出術後に急性心不全をきたし、心エコー検査で重症僧帽弁狭窄症が判明した一例2015