Sakuma Tetsushi 佐久間哲史

… Alternative Names

SAKUMA TETSUSHI 佐久間哲史

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Researcher Number	90711143
Other IDs
Affiliation (Current)	2025: 京都大学, 農学研究科, 特定教授 2025: リージョナルフィッシュ株式会社(研究開発部), 研究開発部, 執行役員
Affiliation (based on the past Project Information) *help	2024: 京都大学, 農学研究科, 特定教授 2022 – 2023: 広島大学, 統合生命科学研究科(理), 教授 2020 – 2022: 広島大学, 統合生命科学研究科(理), 准教授 2019: 広島大学, 統合生命科学研究科(理), 講師 2018: 広島大学, 理学研究科, 講師 … More 2017: 広島大学, 大学院理学研究科, 特任講師 2017: 広島大学, 大学院理学研究科, 講師 2016 – 2017: 広島大学, 理学研究科, 特任講師 2015: 広島大学, 理学(系)研究科(研究院), 特任講師 2013 – 2014: 広島大学, 理学(系)研究科(研究院), 特任助教 2012: 広島大学, 大学院・理学研究科, 特別研究員(PD) Less
Review Section/Research Field	Principal Investigator Basic Section 43060:System genome science-related / System genome science / 応用ゲノム科学 Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 43060:System genome science-related / Basic Section 42040:Laboratory animal science-related / Functional basic dentistry / Integrative animal science / Medical genome science / Cell biology
Keywords	Principal Investigator ゲノム編集 / CRISPR-Cas / TALEN / CRISPR-Cas9 / エピゲノム編集 / がん / 遺伝子ノックイン / ゲノム生物工学 / 人工ヌクレアーゼ / Golden Gate法 … More / MMEJ / マイクロホモロジー媒介性末端結合 / CRISPR/Cas / CRISPR/Cas9 … More Except Principal Investigator ゲノム編集 / 遺伝子 / バイオテクノロジー / 肺大細胞神経内分泌癌 / 肺大細胞性神経内分泌癌 / オルガノイド / 肺大細胞神経内分泌 / ナンノクロロプシス / 微細藻類 / 疾患モデル動物 / エピゲノム編集 / てんかん / 変異 / 骨形成 / 歯学 / 歯根 / 点変異 / Runx2 / 膜性骨化 / 発生・分化 / ゲノム / 核酸 / 核酸導入 / 受精卵 / マウス / SNP / 疾患モデル細胞 / 疾患モデル / 炎症 / 抗体 / 翻訳後修飾 / 線維化 / オステオポンチン Less

Development and application of multi-functional and orthogonal genome editing platform named CRISPR-bacflipPrincipal Investigator
- Principal Investigator
  
  佐久間哲史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Kyoto University
微細藻類における導入遺伝子サイズや導入回数の制限を解除する新規ノックイン法の開発
- Principal Investigator
  
  栗田朋和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Hiroshima University
Elucidation of molecular pathogenesis and carcinogenesis in pulmonary large cell neuroendocrine carcinoma using patient derived organoids
- Principal Investigator
  
  深澤拓也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kawasaki Medical School
マウスin vivo エピゲノム編集による焦点性てんかん発症機序の解明
- Principal Investigator
  
  石田紗恵子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Development of muliplex, large-scale, and high-resolution genome editing technology using multi-class CRISPR systemPrincipal Investigator
- Principal Investigator
  
  Sakuma Tetsushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Hiroshima University
Development of a novel epigenome editing technology using the expanded TREE system and its application in cancer studyPrincipal Investigator
- Principal Investigator
  
  Sakuma Tetsushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Hiroshima University
Development of genome editing platform technology for various disease models
- Principal Investigator
  
  YAMAMOTO TAKASHI
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical genome science
- Research Institution
  Hiroshima University
Development of disease-modeling technology using hierarchical genome/epigenome editingPrincipal Investigator
- Principal Investigator
  
  SAKUMA TETSUSHI
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  Hiroshima University
Establishment of a new mouse model of cledocranial dysplasia by TALEN mediated genome editing
- Principal Investigator
  
  Shukunami Chisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Role of polymeric OPN on fibrosis
- Principal Investigator
  
  Nishimichi Norihisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Hiroshima University
Application of lipofection-mediated genome editing in mouse zygotes created by IVF via ultra-superovulation
- Principal Investigator
  
  Nakagata Naomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Kumamoto University
Development of CRISPR/Cas system enabling advanced genome editing on chromosome levelPrincipal Investigator
- Principal Investigator
  
  SAKUMA TETSUSHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  System genome science
- Research Institution
  Hiroshima University
TALEヌクレアーゼを用いた遺伝子ノックイン/ノックアウト技術の確立と応用Principal Investigator
- Principal Investigator
  
  佐久間哲史
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  応用ゲノム科学
- Research Institution
  Hiroshima University

[Book] 実験医学2023年12月号2023
- Author(s)
  佐久間　哲史、赤瀬　まりな
- Total Pages
  131
- Publisher
  羊土社
- ISBN
  9784758125741
- Data Source
  KAKENHI-PROJECT-21K06137
[Book] 腎と透析2023
- Author(s)
  西川想大, 佐久間哲史
- Total Pages
  168
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-21K06137
[Book] 実験医学 2021年5月号 Vol.39 No.8 CRISPR最新ツールボックス2021
- Author(s)
  山本卓, 佐久間哲史
- Total Pages
  137
- Publisher
  羊土社
- ISBN
  9784758125437
- Data Source
  KAKENHI-PROJECT-21K06137
[Book] 完全版　ゲノム編集実験スタンダード2019
- Author(s)
  山本　卓、佐久間哲史
- Total Pages
  386
- Publisher
  羊土社
- ISBN
  9784758122443
- Data Source
  KAKENHI-PROJECT-17H01409
[Book] 完全版　ゲノム編集実験スタンダード2019
- Author(s)
  山本　卓、佐久間　哲史
- Total Pages
  386
- Publisher
  羊土社
- ISBN
  475812244X
- Data Source
  KAKENHI-PROJECT-19K16111
[Book] RNAi and Small Regulatory RNAs in Stem Cells - Methods in Molecular Biology2017
- Author(s)
  Takata N, Sakakura E, Sakuma T, Yamamoto T.
- Total Pages
  24
- Publisher
  Springer
- ISBN
  9781493971060
- Data Source
  KAKENHI-PROJECT-16K18478
[Book] In Vitro Mutagenesis, Methods in Molecular Biology2017
- Author(s)
  Sakuma T, Sakamoto T, Yamamoto T
- Total Pages
  16
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16K18478
[Book] Genome Editing in Animals - Methods in Molecular Biology2017
- Author(s)
  Sakuma T, Yamamoto T.
- Total Pages
  12
- Publisher
  Springer
- ISBN
  9781493971275
- Data Source
  KAKENHI-PROJECT-16K18478
[Book] Targeted Genome Editing Using Engineered Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System2015
- Author(s)
  Sakuma T, Yamamoto T (Yamamoto T, ed.)
- Total Pages
  205
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25890014
[Book] 実験医学別冊「今すぐ始めるゲノム編集」2014
- Author(s)
  佐久間哲史（山本卓編）
- Total Pages
  205
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance2024
- Author(s)
  Nakatani Kazuma、Kogashi Hiroyuki、Miyamoto Takanori、Setoguchi Taiki、Sakuma Tetsushi、Kugou Kazuto、Hasegawa Yoshinori、Yamamoto Takashi、Hippo Yoshitaka、Suenaga Yusuke
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 14 Pages: 1237378-1237378
- DOI
  10.3389/fonc.2024.1237378
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-21K08610
[Journal Article] REMOVER-PITCh: microhomology-assisted long-range gene replacement with highly multiplexed CRISPR-Cas92024
- Author(s)
  Matsuzaki Shu、Sakuma Tetsushi、Yamamoto Takashi
- Journal Title
  
  In Vitro Cellular and Developmental Biology - Animal
  
  Volume: - Issue: 7 Pages: 697-707
- DOI
  10.1007/s11626-024-00850-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Transcription activator-like effector nuclease-mediated deletion safely eliminates the major egg allergen ovomucoid in chickens2023
- Author(s)
  Ezaki Ryo、Sakuma Tetsushi、Kodama Daisuke、Sasahara Ryou、Shiraogawa Taichi、Ichikawa Kennosuke、Matsuzaki Mei、Handa Akihiro、Yamamoto Takashi、Horiuchi Hiroyuki
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 175 Pages: 113703-113703
- DOI
  10.1016/j.fct.2023.113703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-23K27057
[Journal Article] Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells2023
- Author(s)
  Takashina Tomoki、Matsunaga Akihiro、Shimizu Yukiko、Sakuma Tetsushi、Okamura Tadashi、Matsuoka Kunie、Yamamoto Takashi、Ishizaka Yukihito
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 3 Pages: e0051-e0051
- DOI
  10.1097/hc9.0000000000000051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration2023
- Author(s)
  Newman Daniel、Young Lorna E.、Waring Thomas、Brown Louise、Wolanska Katarzyna I.、MacDonald Ewan、Charles-Orszag Arthur、Goult Benjamin T.、Caswell Patrick T.、Sakuma Tetsushi、Yamamoto Takashi、Machesky Laura M.、Morgan Mark R.、Zech Tobias
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 12 Pages: 113554-113554
- DOI
  10.1016/j.celrep.2023.113554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Developmental changes in brain activity of heterozygous Scn1a knockout rats2023
- Author(s)
  Tahara Mayu、Higurashi Norimichi、Hata Junichi、Nishikawa Masako、Ito Ken、Hirose Shinichi、Kaneko Takehito、Mashimo Tomoji、Sakuma Tetsushi、Yamamoto Takashi、Okano Hirotaka James
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 1125089-1125089
- DOI
  10.3389/fneur.2023.1125089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-21K07780, KAKENHI-PROJECT-18KK0307
[Journal Article] Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a22023
- Author(s)
  Ohga Hirofumi、Shibata Koki、Sakanoue Ryo、Ogawa Takuma、Kitano Hajime、Kai Satoshi、Ohta Kohei、Nagano Naoki、Nagasako Tomoya、Uchida Seiichi、Sakuma Tetsushi、Yamamoto Takashi、Kim Sangwan、Tashiro Kosuke、Kuhara Satoru、Gen Koichiro、Fujiwara Atushi、Kazeto Yukinori、Kobayashi Takanori、Matsuyama Michiya
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3190-3190
- DOI
  10.1038/s41598-023-30259-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00951
[Journal Article] Genome editing for biodiesel production in oleaginous microalga, Nannochloropsis species2023
- Author(s)
  Kurita Tomokazu、Iwai Masako、Ohta Hiroyuki、Sakuma Tetsushi、Yamamoto Takashi
- Journal Title
  
  Gene and Genome Editing
  
  Volume: 6 Pages: 100027-100027
- DOI
  10.1016/j.ggedit.2023.100027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN2023
- Author(s)
  Tanihara Fuminori、Hirata Maki、Namula Zhao、Do Lanh Thi Kim、Yoshimura Naoaki、Lin Qingyi、Takebayashi Koki、Sakuma Tetsushi、Yamamoto Takashi、Otoi Takeshige
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11 Pages: 884340-884340
- DOI
  10.3389/fcell.2023.884340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-22K19896
[Journal Article] Platinum Talen-Mediated Knock-in of Single-Stranded DNA Templates Facilitates Manufacturing of Clinical-Scale Non-Virally Gene-Edited T Cells from Peripheral Blood2023
- Author(s)
  Toishigawa Kayo、Edahiro Taro、Magoori Kenta、Sato Hiroyuki、Fukunaga Saori、Budirahardja Yemima Suryani、Ureshino Hiroshi、Suzuki Ryuji、Sakuma Tetsushi、Yamamoto Takashi、Ichinohe Tatsuo
- Journal Title
  
  Blood
  
  Volume: 142 Issue: Supplement 1 Pages: 6794-6794
- DOI
  10.1182/blood-2023-178451
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] UGGT1/2-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins2023
- Author(s)
  Ninagawa Satoshi、Matsuo Masaki、Ying Deng、Aso Shinya、Matsushita Kazutoshi、Fueki Akane、Saito Shunsuke、Imami Koshi、Kizuka Yasuhiko、Sakuma Tetsushi、Yamamoto Takashi、Yagi Hirokazu、Kato Koichi、Mori Kazutoshi
- Journal Title
  
  e Life
  
  Volume: - Pages: 1-29
- DOI
  10.7554/elife.93117.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08605, KAKENHI-PROJECT-21K06137, KAKENHI-ORGANIZER-23H03834, KAKENHI-PLANNED-23H03838, KAKENHI-PROJECT-23K21358
[Journal Article] Updated Overview of TALEN Construction Systems2023
- Author(s)
  Sakuma Tetsushi、Yamamoto Takashi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2637 Pages: 27-39
- DOI
  10.1007/978-1-0716-3016-7_2
- ISBN
  9781071630150, 9781071630167
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Genome editing2022
- Author(s)
  McGrail Maura、Sakuma Tetsushi、Bleris Leonidas
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20497-20497
- DOI
  10.1038/s41598-022-24850-x
- NAID
  40020672959
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology2022
- Author(s)
  Sayumi Shimode, Tetsushi Sakuma, Takashi Yamamoto, Takayuki Miyazawa
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 6641-6641
- DOI
  10.1038/s41598-022-10497-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15692, KAKENHI-PROJECT-21K06137
[Journal Article] Genome editing with removable TALEN vectors harboring a yeast centromere and autonomous replication sequence in oleaginous microalga2022
- Author(s)
  Kurita T, Iwai M, Moroi K, Okazaki K, Nomura S, Saito F, Maeda S, Takami A, Sakamoto A, Ohta H, Sakuma T,
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2480-2480
- DOI
  10.1038/s41598-022-06495-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06725, KAKENHI-PROJECT-21K06137
[Journal Article] Panel of human cell lines with human/mouse artificial chromosomes2022
- Author(s)
  Narumi Uno, Shuta Takata, Shinya Komoto, Hitomaru Miyamoto, Yuji Nakayama, Mitsuhiko Osaki, Ryota Mayuzumi, Natsumi Miyazaki, Chiaki Hando, Satoshi Abe, Tetsushi Sakuma, Takashi Yamamoto, Teruhiko Suzuki, Yoshihiro Nakajima, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 3009-3009
- DOI
  10.1038/s41598-022-06814-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-22K06085, KAKENHI-PROJECT-21H02083
[Journal Article] Gene manipulation in the Mucorales fungus Rhizopus oryzae using TALENs with exonuclease overexpression2022
- Author(s)
  Yuichi Tsuboi, Tetsushi Sakuma, Takashi Yamamoto, Hiroyuki Horiuchi, Fumikazu Takahashi, Kazuaki Igarashi, Hiroshi Hagihara, Yasushi Takimura
- Journal Title
  
  FEMS Microbiology Letters
  
  Volume: 369 Issue: 1
- DOI
  10.1093/femsle/fnac010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Design, Construction, and Validation of Targeted Gene Activation with TREE System in Human Cells2022
- Author(s)
  Kunii Atsushi、Yamamoto Takashi、Sakuma Tetsushi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2577 Pages: 211-226
- DOI
  10.1007/978-1-0716-2724-2_15
- ISBN
  9781071627235, 9781071627242
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Pou5f3.3 is involved in establishment and maintenance of hematopoietic cells during Xenopus development2021
- Author(s)
  Ezawa Minami、Kouno Fumika、Kubo Hideo、Sakuma Tetsushi、Yamamoto Takashi、Kinoshita Tsutomu
- Journal Title
  
  Tissue and Cell
  
  Volume: 72 Pages: 101531-101531
- DOI
  10.1016/j.tice.2021.101531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06269, KAKENHI-PROJECT-19K16111
[Journal Article] Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation2021
- Author(s)
  Arima Yuichiro、Nakagawa Yoshiko、Takeo Toru、Ishida Toshifumi、Yamada Toshihiro、et al.
- Journal Title
  
  Nature Metabolism
  
  Volume: 3 Issue: 2 Pages: 196-210
- DOI
  10.1038/s42255-021-00342-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08110, KAKENHI-PROJECT-19K08520, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-20H04108, KAKENHI-PROJECT-18K06817, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-19H04446, KAKENHI-PROJECT-21H02686, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K19519, KAKENHI-PROJECT-20KK0185, KAKENHI-PROJECT-18H02798, KAKENHI-PROJECT-19H01048
[Journal Article] Improvement of fatty acid productivity of thraustochytrid, Aurantiochytrium sp. by genome editing2021
- Author(s)
  K. Watanabe, C.M.T. Perez, T. Kitahori, K. Hata, M. Aoi, H. Takahashi, T. Sakuma, Y. Okamura, Y. Nakashimada, T. Yamamoto, K. Matsuyama, S. Mayuzumi, T. Aki
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 131 Issue: 4 Pages: 373-380
- DOI
  10.1016/j.jbiosc.2020.11.013
- NAID
  40022545824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05232, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-21K14772
[Journal Article] TALEN-Mediated Gene Editing of slc24a5 (Solute Carrier Family 24, Member 5) in Kawakawa, Euthynnus affinis2021
- Author(s)
  Dipak Pandey, Takahiro Matsubara, Taiju Saito, Yukinori Kazeto, Koichiro Gen, Tetsushi Sakuma, Takashi Yamamoto, Miyuki Mekuchi, Rie Goto
- Journal Title
  
  Journal of Marine Science and Engineering
  
  Volume: 9 Issue: 12 Pages: 1378-1378
- DOI
  10.3390/jmse9121378
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137
[Journal Article] Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.2021
- Author(s)
  Nishinaka-Arai Y, Niwa A, Matsuo S, Kazuki Y, Yakura Y, Hiroma T, Toki T, Sakuma T, Yamamoto T, Ito E, Oshimura M, Nakahata T, Saito MK.
- Journal Title
  
  Haematologica
  
  Volume: 106(2) Issue: 2 Pages: 635-640
- DOI
  10.3324/haematol.2019.242693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17358, KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-19K16111
[Journal Article] CRISPR-Cas9 editing of non-coding genomic loci as a means of controlling gene expression in the sea urchin.2021
- Author(s)
  Pieplow A, Dastaw M, Sakuma T, Sakamoto N, Yamamoto T, Yajima M, Oulhen N, Wessel GM
- Journal Title
  
  Developmental Biology
  
  Volume: 472 Pages: 85-97
- DOI
  10.1016/j.ydbio.2021.01.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06602, KAKENHI-PROJECT-18K06149, KAKENHI-PROJECT-19K16111
[Journal Article] Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF62020
- Author(s)
  Koba Hibiki、Jin Shengyu、Imada Nanami、Ishikawa Tokiro、Ninagawa Satoshi、Okada Tetsuya、Sakuma Tetsushi、Yamamoto Takashi、Mori Kazutoshi
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 45 Issue: 1 Pages: 9-21
- DOI
  10.1247/csf.19030
- NAID
  130007792116
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16111, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18K06216
[Journal Article] Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga, Nannochloropsis oceanica NIES‐21452020
- Author(s)
  Kurita T, Moroi K, Iwai M, Okazaki K, Shimizu S, Nomura S, Saito F, Maeda S, Takami A, Sakamoto A, Ohta H, Sakuma T, Yamamoto T
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Issue: 10 Pages: 695-702
- DOI
  10.1111/gtc.12805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06725, KAKENHI-PROJECT-19K16111
[Journal Article] Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells2020
- Author(s)
  Teratake Y, Takashina T, Iijima K, Sakuma T, Yamamoto T, Ishizaka Y
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 6 Pages: 823-834
- DOI
  10.1038/s41416-019-0708-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16111
[Journal Article] Three multi-allelic gene pairs are responsible for self-sterility in the ascidian Ciona intestinalis2020
- Author(s)
  Sawada H, Yamamoto K, Yamaguchi A, Yamada L, Higuchi A, Nukaya H, Fukuoka M, Sakuma T, Yamamoto T, Sasakura Y, Shirae-Kurabayashi M
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 2514-2514
- DOI
  10.1038/s41598-020-59147-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17K19520
[Journal Article] Various strategies of effector accumulation to improve the efficiency of genome editing and derivative methodologies2020
- Author(s)
  Kunii A, Yamamoto T, Sakuma T
- Journal Title
  
  In Vitro Cellular & Developmental Biology - Animal
  
  Volume: 56 Issue: 5 Pages: 359-366
- DOI
  10.1007/s11626-020-00469-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20J13292, KAKENHI-PROJECT-19K16111
[Journal Article] GABA-Induced GnRH Release Triggers Chordate Metamorphosis.2020
- Author(s)
  Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, Sakuma T, Yamamoto T, Shiraishi A, Hamada M, Satoh N, Sakurai K, Satake H, Sasakura Y.
- Journal Title
  
  Current Biology
  
  Volume: 30 Issue: 8 Pages: 1555-1561
- DOI
  10.1016/j.cub.2020.02.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03204, KAKENHI-PROJECT-16K07433, KAKENHI-PROJECT-19K06752, KAKENHI-PROJECT-20K06737, KAKENHI-PROJECT-19H03262, KAKENHI-PROJECT-19K16111
[Journal Article] Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice2020
- Author(s)
  Shindo Ryodai、Katagiri Takaharu、Komazawa-Sakon Sachiko、Ohmuraya Masaki、Takeda Wakami、Nakagawa Yoshiko、Nakagata Naomi、Sakuma Tetsushi、Yamamoto Takashi、Nishiyama Chiharu、Nishina Takashi、Yamazaki Soh、Kameda Hideto、Nakano Hiroyasu
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100738-100738
- DOI
  10.1016/j.bbrep.2020.100738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-19K08405, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-20H02939, KAKENHI-PROJECT-19K07391
[Journal Article] ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk2020
- Author(s)
  Mariko Sekiguchi, Akiko Kodama,... Emiko Shishido,... Daisuke Mori, Norio Ozaki
- Journal Title
  
  Translational psychiatry
  
  Volume: 10 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41398-020-00917-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08072, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K07965, KAKENHI-PROJECT-20K21832, KAKENHI-PROJECT-18K14816, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20K16625, KAKENHI-PROJECT-19H05467, KAKENHI-PUBLICLY-19H05210, KAKENHI-PUBLICLY-20H04841, KAKENHI-PROJECT-18H04040, KAKENHI-PROJECT-20H03611, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-17K07383, KAKENHI-PROJECT-18K15512, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H04252, KAKENHI-PROJECT-18KT0022
[Journal Article] TALEN‐mediated generation of Nkx3.1 knockout rat model2020
- Author(s)
  Lee Ji Min、Kim Ukjin、Yang Hyokyung、Ryu Bokyeong、Kim Jin、Sakuma Tetsushi、Yamamoto Takashi、Park Jae‐Hak
- Journal Title
  
  The Prostate
  
  Volume: 81 Issue: 3 Pages: 182-193
- DOI
  10.1002/pros.24095
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16111
[Journal Article] Hox13 is essential for formation of a sensory organ at the terminal end of the sperm duct in Ciona2020
- Author(s)
  Tajima Y, Hozumi A, Yoshida K, Treen N, Sakuma T, Yamamoto T, Sasakura Y
- Journal Title
  
  Developmental Biology
  
  Volume: 458 Issue: 1 Pages: 120-131
- DOI
  10.1016/j.ydbio.2019.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-19H03262
[Journal Article] EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD2020
- Author(s)
  George Ginto、Ninagawa Satoshi、Yagi Hirokazu、Saito Taiki、Ishikawa Tokiro、Sakuma Tetsushi、Yamamoto Takashi、Imami Koshi、Ishihama Yasushi、Kato Koichi、Okada Tetsuya、Mori Kazutoshi
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.53455
- NAID
  120006817590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06110, KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16111, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18K06216, KAKENHI-PLANNED-17H06414
[Journal Article] Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.2020
- Author(s)
  Takahashi Masanori、Ikeda Keiko、Ohmuraya Masaki、Nakagawa Yoshiko、Sakuma Tetsushi、Yamamoto Takashi、Kawakami Kiyoshi
- Journal Title
  
  Developmental Dynamics
  
  Volume: 0 Issue: 9 Pages: 0-0
- DOI
  10.1002/dvdy.174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06968, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-19K07253, KAKENHI-PROJECT-19K16111
[Journal Article] DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria2020
- Author(s)
  Ozawa K, Tsumoto H, Miura Y, Yamaguchi J, Iguchi-Ariga SMM, Sakuma T, Yamamoto T, Uchiyama Y
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4377-4377
- DOI
  10.1038/s41598-020-61287-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16111
[Journal Article] Pathological characteristics of <i>Ccdc85c</i> knockout rats: a rat model of genetic hydrocephalus2020
- Author(s)
  Konishi S, Tanaka N, Mashimo T, Yamamoto T, Sakuma T, Kaneko T, Tanaka M, Izawa T, Yamate J, Kuwamura M
- Journal Title
  
  Exp. Anim.
  
  Volume: 69 Issue: 1 Pages: 26-33
- DOI
  10.1538/expanim.19-0005
- NAID
  130007791587
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-18H03974
[Journal Article] Anephrogenic phenotype induced by SALL1 gene knockout in pigs.2019
- Author(s)
  Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 8016-8016
- DOI
  10.1038/s41598-019-44387-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H01409
[Journal Article] Targeted mutagenesis of the ryanodine receptor by Platinum TALENs causes slow swimming behaviour in Pacific bluefin tuna (Thunnus orientalis)2019
- Author(s)
  Higuchi K, Kazeto Y, Ozaki Y, Yamaguchi T, Shimada Y, Ina Y, Soma S, Sakakura Y, Goto R, Matsubara T, Nishiki I, Iwasaki Y, Yasuike M, Nakamura Y, Matsuura A, Masuma S, Sakuma T, Yamamoto T, Masaoka T, Kobayashi T, Fujiwara A, Gen K
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13871-13871
- DOI
  10.1038/s41598-019-50418-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16111
[Journal Article] Establishment of knockout adult sea urchins by using a CRISPR‐Cas9 system2019
- Author(s)
  Daming Liu, Akinori Awazu, Tetsushi Sakuma, Takashi Yamamoto, Naoaki Sakamoto
- Journal Title
  
  Development Growth and Regeneration
  
  Volume: 61 Issue: 6 Pages: 378-388
- DOI
  10.1111/dgd.12624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0024, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-16H04035, KAKENHI-PROJECT-17K05614, KAKENHI-PROJECT-17K07241
[Journal Article] Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors.2019
- Author(s)
  Tanigawa S, Naganuma H, Kaku Y, Era T, Sakuma T, Yamamoto T, Taguchi A and Nishinakamura R.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 2 Pages: 322-337
- DOI
  10.1016/j.stemcr.2019.07.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-19K08707, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H06177, KAKENHI-PROJECT-17H01409
[Journal Article] TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma2019
- Author(s)
  Suenaga Yusuke、Yamamoto Mami、Sakuma Tetsushi、Sasada Manabu、Fukai Fumio、Ohira Miki、Yamaguchi Yohko、Yamamoto Takashi、Ando Kiyohiro、Ozaki Toshinori、Nakagawara Akira
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 518 Issue: 2 Pages: 311-318
- DOI
  10.1016/j.bbrc.2019.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07246, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17K10131
[Journal Article] Efficient genome engineering using Platinum TALEN in potato2019
- Author(s)
  Yasumoto S, Umemoto N, Lee HJ, Nakayasu M, Sawai S, Sakuma T, Yamamoto T, Mizutani M, Saito K, Muranaka T
- Journal Title
  
  Plant Biotechnology
  
  Volume: 36 Issue: 3 Pages: 167-173
- DOI
  10.5511/plantbiotechnology.19.0805a
- NAID
  130007724769
- ISSN
  1342-4580, 1347-6114
- Year and Date
  2019-09-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16111
[Journal Article] PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer2018
- Author(s)
  Kuriyama S, Tsuji T, Sakuma T, Yamamoto T, Tanaka M
- Journal Title
  
  Cell Death Discovery
  
  Volume: 4 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41420-017-0006-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0104, KAKENHI-PROJECT-17K19579, KAKENHI-PROJECT-16H04691, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-18K07192
[Journal Article] Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene2018
- Author(s)
  Tanaka Yasuyoshi、Sone Takefumi、Higurashi Norimichi、Sakuma Tetsushi、Suzuki Sadafumi、Ishikawa Mitsuru、Yamamoto Takashi、Mitsui Jun、Tsuji Hitomi、Okano Hideyuki、Hirose Shinichi
- Journal Title
  
  Stem Cell Research
  
  Volume: 28 Pages: 100-104
- DOI
  10.1016/j.scr.2018.01.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-26860833, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-16K15532
[Journal Article] Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays2018
- Author(s)
  Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T, Sakuma T.
- Journal Title
  
  CRISPR J
  
  Volume: 1 Issue: 5 Pages: 337-347
- DOI
  10.1089/crispr.2018.0009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01409
[Journal Article] Tailor-made gene silencing of Staphylococcus aureus clinical isolates by CRISPR interference2018
- Author(s)
  Sato'o Y, Hisatsune J, Yu L, Sakuma T, Yamamoto T, Sugai M.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 1 Pages: e0185987-e0185987
- DOI
  10.1371/journal.pone.0185987
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Unexpected heterogeneity derived from Cas9 ribonucleoprotein-introduced clonal cells at the HPRT1 locus2018
- Author(s)
  Sakuma T, Mochida K, Nakade S, Ezure T, Minagawa S, Yamamoto T.
- Journal Title
  
  Genes Cells
  
  Volume: 23 Issue: 4 Pages: 255-263
- DOI
  10.1111/gtc.12569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.2018
- Author(s)
  Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y.
- Journal Title
  
  Scientific reports
  
  Volume: 8 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-018-21194-3
- NAID
  120006522882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17092, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-18J40203
[Journal Article] Genome editing for dissecting and curing human genetic diseases2018
- Author(s)
  Sakuma T, Yamamoto T.
- Journal Title
  
  J Hum Genet
  
  Volume: 63 Issue: 2 Pages: 105-105
- DOI
  10.1038/s10038-017-0380-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems2018
- Author(s)
  Kawabe Y, Komatsu S, Komatsu S, Murakami M, Ito A, Sakuma T, Nakamura T, Yamamoto T, Kamihira M.
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 125 Issue: 5 Pages: 599-605
- DOI
  10.1016/j.jbiosc.2017.12.003
- NAID
  40021552678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Microhomology-assisted scarless genome editing in human iPSCs2018
- Author(s)
  Kim Shin-Il、Matsumoto Tomoko、Kagawa Harunobu、Nakamura Michiko、Hirohata Ryoko、Ueno Ayano、Ohishi Maki、Sakuma Tetsushi、Soga Tomoyoshi、Yamamoto Takashi、Woltjen Knut
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 939-939
- DOI
  10.1038/s41467-018-03044-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07256, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-16K18478
[Journal Article] Biased genome editing using the local accumulation of DSB repair molecules system.2018
- Author(s)
  Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T
- Journal Title
  
  Nature Communications
  
  Volume: 9(1) Issue: 1 Pages: 3270-3270
- DOI
  10.1038/s41467-018-05773-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07241, KAKENHI-PROJECT-18K19494, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-17H02216, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-17K15045
[Journal Article] Magic wands of CRISPR-lots of choices for gene knock-in2017
- Author(s)
  Sakuma T, Yamamoto T.
- Journal Title
  
  Cell Biol Toxicol
  
  Volume: 33 Issue: 6 Pages: 501-505
- DOI
  10.1007/s10565-017-9409-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells2017
- Author(s)
  Kaku Y, Taguchi A, Tanigawa S, Haque F, Sakuma T, Yamamoto T, Nishinakamura R.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 4554-4554
- DOI
  10.1038/s41598-017-04813-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H06177
[Journal Article] Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology2017
- Author(s)
  Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki K, Takehara S, Nakamura K, Okada A, Tsukazaki Y, Senda N, Honma K, Yamamoto T, Ikawa M, Chiba K, Oshimura M, Kazuki Y.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 15189-15189
- DOI
  10.1038/s41598-017-15033-0
- NAID
  120006957433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN systems2017
- Author(s)
  Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 45 Issue: 9 Pages: 5198-5207
- DOI
  10.1093/nar/gkx130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06365, KAKENHI-PROJECT-16K18478
[Journal Article] Cpf1 and C2c1/2/3―What's next?2017
- Author(s)
  Shota Nakade, Takashi Yamamoto, Tetsushi Sakuma.
- Journal Title
  
  Bioengineered
  
  Volume: - Issue: 3 Pages: 265-273
- DOI
  10.1080/21655979.2017.1282018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J03164, KAKENHI-PROJECT-16K18478
[Journal Article] TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation.2017
- Author(s)
  Nakamura M, Kumrungsee T, Sakuma T, Yamamoto T, Yanaka N.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 81 Issue: 11 Pages: 2164-2167
- DOI
  10.1080/09168451.2017.1373593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07757, KAKENHI-PROJECT-16K18478
[Journal Article] Cancer induction and suppression with transcriptional control and epigenome editing technologies.2017
- Author(s)
  Nakade S, Yamamoto T, Sakuma T.
- Journal Title
  
  Journal of human genetics
  
  Volume: 1 Issue: 2 Pages: 187-194
- DOI
  10.1038/s10038-017-0377-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15045, KAKENHI-PROJECT-16K18478
[Journal Article] Germ cell regeneration-mediated, enhanced mutagenesis in the ascidian Ciona intestinalis reveals flexible germ cell formation from different somatic cells.2017
- Author(s)
  Yoshida K, Hozumi A, Treen N, Sakuma T, Yamamoto T, Shirae-Kurabayashi M, Sasakura Y.
- Journal Title
  
  Developmental Biology
  
  Volume: 423 Issue: 2 Pages: 111-125
- DOI
  10.1016/j.ydbio.2017.01.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04815, KAKENHI-PROJECT-15K14520, KAKENHI-PROJECT-16K18478
[Journal Article] Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017
- Author(s)
  Nakagawa Y, Sakuma T, Nishimichi N, Yokosaki Y, Takeo T, Nakagata N, Yamamoto T
- Journal Title
  
  Biology Open
  
  Volume: - Pages: 706-713
- DOI
  10.1242/bio.025122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-17H04161
[Journal Article] ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.2017
- Author(s)
  Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.
- Journal Title
  
  PLos One
  
  Volume: 12 Issue: 11 Pages: e0188320-e0188320
- DOI
  10.1371/journal.pone.0188320
- NAID
  120006800808
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05333, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01737, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16J02252, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01877
[Journal Article] Establishment of expanded and streamlined pipeline of PITCh knock-in - a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO2017
- Author(s)
  Nakamae K, Nishimura Y, Takenaga M, Nakade S, Sakamoto N, Ide H, Sakuma T, Yamamoto T
- Journal Title
  
  Bioengineered
  
  Volume: - Issue: 3 Pages: 302-308
- DOI
  10.1080/21655979.2017.1313645
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01409
[Journal Article] Establishment of pten knockout medaka with transcription activator-like effector nucleases (TALENs) as a model of PTEN deficiency disease2017
- Author(s)
  Matsuzaki Y, Sakuma T, Yamamoto T, Saya H.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 10 Pages: e0186878-e0186878
- DOI
  10.1371/journal.pone.0186878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant2017
- Author(s)
  Mizutani, O., Arazoe, T., Toshida, K., Hayashi, R., Ohsato, S., Skuma, T., Yamamoto, T., Kuwata, S. and Yamada, O.
- Journal Title
  
  Journal of Biotechnology and Bioengineering
  
  Volume: 3 Issue: 3 Pages: 287-293
- DOI
  10.1016/j.jbiosc.2016.09.014
- NAID
  40021152739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18647, KAKENHI-PROJECT-16K07706, KAKENHI-PROJECT-16K18478
[Journal Article] Hox-mediated endodermal identity patterns the pharyngeal muscle formation in the chordate pharynx2017
- Author(s)
  Yoshida K, Nakahata A, Treen N, Sakuma T, Yamamoto T, Sasakura Y
- Journal Title
  
  Development
  
  Volume: - Pages: 1629-1634
- DOI
  10.1242/dev.144436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-16H04815
[Journal Article] Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus.2016
- Author(s)
  Sakuma T, Masaki K, Abe-Chayama H, Mochida K, Yamamoto T, Chayama K.
- Journal Title
  
  Genes Cells.
  
  Volume: 21 Issue: 11 Pages: 1253-1262
- DOI
  10.1111/gtc.12437
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-16K18478
[Journal Article] Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single- amino-acid-substituted, and floxed mice2016
- Author(s)
  Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata and Takashi Yamamoto
- Journal Title
  
  Biology Open
  
  Volume: 5 Issue: 8 Pages: 1142-1148
- DOI
  10.1242/bio.019349
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26293174, KAKENHI-PROJECT-26660112, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-16K18478
[Journal Article] Transcriptional regulation of a horizontally transferred gene from bacterium to chordate.2016
- Author(s)
  Sasakura Y, Ogura Y, Treen N, Yokomori R, Park SJ, Nakai K, Saiga H, Sakuma T, Yamamoto T, Fujiwara S, Yoshida K.
- Journal Title
  
  Proc Biol Sci.
  
  Volume: 283 Issue: 1845 Pages: 20161712-20161712
- DOI
  10.1098/rspb.2016.1712
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04815, KAKENHI-PROJECT-25440113, KAKENHI-PROJECT-16K18478
[Journal Article] Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ.2016
- Author(s)
  Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T, Aizawa H, Yamamoto T, Tanaka K.
- Journal Title
  
  BMC Genomics
  
  Volume: 17 Issue: 1 Pages: 979-979
- DOI
  10.1186/s12864-016-3331-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01383, KAKENHI-PLANNED-26112010, KAKENHI-PROJECT-16J03164, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26430008, KAKENHI-PROJECT-15K19988, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K18478
[Journal Article] Single-Cell-State Culture of Human Pluripotent Stem Cells Increases Transfection Efficiency2016
- Author(s)
  Nii T, Kohara H, Marumoto T, Sakuma T, Yamamoto T, Tani K
- Journal Title
  
  Bioresearch Open Access
  
  Volume: 5 Issue: 1 Pages: 127-136
- DOI
  10.1089/biores.2016.0009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18478
[Journal Article] Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy2016
- Author(s)
  Tochio,N., Umehara,K., Uewaki,J., Flechsig,H., Kondo,M., Dewa,T., Sakuma,T., Yamamoto,T., Saito,T., Togashi,T., Tate,S.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 37887-37887
- DOI
  10.1038/srep37887
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26291015, KAKENHI-PROJECT-16K18478
[Journal Article] Systematic cellular disease models reveal synergistic interactions of trisomy 21 and GATA1 mutations in hematopoietic abnormalities2016
- Author(s)
  K. Banno, S. Omori, K. Hirata, N. Nawa, N. Nakagawa, K. Nishimura, M. Ohtaka, M. Nakanishi, T. Sakuma, T. Yamamoto, T. Toki, E. Ito, T. Yamamoto, C. Kokubu, J. Takeda, H. Taniguchi, H. Arahori, K. Wada, Y. Kitabatake and K. Ozono
- Journal Title
  
  Cell Reports
  
  Volume: 15 Issue: 6 Pages: 1-15
- DOI
  10.1016/j.celrep.2016.04.031
- NAID
  120007135439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461583, KAKENHI-PROJECT-14J04075, KAKENHI-PROJECT-24591601, KAKENHI-PROJECT-25461546, KAKENHI-PROJECT-25461643, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-15K15384, KAKENHI-PROJECT-26860799, KAKENHI-PROJECT-16K10090, KAKENHI-PROJECT-16K18478
[Journal Article] Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa2016
- Author(s)
  Sasaki T, Hanisch FG, Deutzmann R, Sakai LY, Sakuma T, Miyamoto T, Yamamoto T, Hannappel E, Chu ML, Lanig H, von der Mark K
- Journal Title
  
  Matrix Biol
  
  Volume: 56 Pages: 132-149
- DOI
  10.1016/j.matbio.2016.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04321, KAKENHI-PROJECT-26701006, KAKENHI-PROJECT-15K15082, KAKENHI-PROJECT-26461661, KAKENHI-PROJECT-15K15017, KAKENHI-PROJECT-16K18478
[Journal Article] Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.2016
- Author(s)
  Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata J, Okano H, Sasaki E.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 19 Issue: 1 Pages: 127-138
- DOI
  10.1016/j.stem.2016.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18405, KAKENHI-PROJECT-16K18478
[Journal Article] C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection2016
- Author(s)
  Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 6 Pages: 1245-1257
- DOI
  10.1016/j.immuni.2016.10.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06496, KAKENHI-PLANNED-26110003, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-16J06299, KAKENHI-PROJECT-26293098, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-15K08468, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-16K18478
[Journal Article] Homeolog-specific targeted mutagenesis in Xenopus laevis using TALENs2015
- Author(s)
  Nakade S, Sakuma T, Sakane Y, Hara Y, Kurabayashi A, Kashiwagi K, Kashiwagi A, Yamamoto T, Obara M
- Journal Title
  
  In Vitro Cell Dev Biol Anim
  
  Volume: - Issue: 9 Pages: 879-884
- DOI
  10.1007/s11626-015-9912-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Desmocollin-2 alone forms functional desmosomal plaques, with the plaque formation requiring the juxtamembrane region and plakophilins2015
- Author(s)
  Fujiwara M, Nagatomo A, Tsuda M, Obata S, Sakuma T, Yamamoto T, Suzuki ST
- Journal Title
  
  J Biochem
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish.2015
- Author(s)
  Hisano Y, Sakuma T, Nakade S, Ohga R, Ota S, Okamoto H, Yamamoto T, Kawahara A.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 8841-8841
- DOI
  10.1038/srep08841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23120008, KAKENHI-PUBLICLY-25116722, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26460088, KAKENHI-PROJECT-26640064, KAKENHI-PROJECT-13J04914, KAKENHI-PROJECT-26870845
[Journal Article] The microtubule depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation2015
- Author(s)
  Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Matsuura S
- Journal Title
  
  Cell Reports
  
  Volume: 10 Issue: 5 Pages: 664-673
- DOI
  10.1016/j.celrep.2015.01.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PUBLICLY-25113521, KAKENHI-PROJECT-25830138, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26701006, KAKENHI-PROJECT-15K09674
[Journal Article] Cloning-free CRISPR/Cas system facilitates functional cassette knockin in mice2015
- Author(s)
  Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka K, Sakuma T, Yamamoto T, Tanaka K
- Journal Title
  
  Genome Biol
  
  Volume: 16 Issue: 1 Pages: 87-87
- DOI
  10.1186/s13059-015-0653-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290021, KAKENHI-PLANNED-25117005, KAKENHI-PROJECT-15H03123, KAKENHI-PROJECT-26830131
[Journal Article] Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine2015
- Author(s)
  Kawai　N, Ogura Y, Ikuta T, Saiga H, Hamada M, Sakuma T, Yamamoto T, Satoh N, Sasakura Y
- Journal Title
  
  Developmental Biology
  
  Volume: 印刷中 Issue: 1 Pages: 43-56
- DOI
  10.1016/j.ydbio.2015.03.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-25440113
[Journal Article] A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector2015
- Author(s)
  Ebina H, Kanemura Y, Misawa N, Sakuma T, Kobayashi T, Yamamoto T, Koyanagi Y
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0120047-e0120047
- DOI
  10.1371/journal.pone.0120047
- NAID
  120005619759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26670168, KAKENHI-PLANNED-24115008
[Journal Article] Tailor-made TALEN system for highly efficient targeted gene replacement in the rice blast fungus2015
- Author(s)
  Arazoe T, Ogawa T, Miyoshi K, Yamato T, Ohsato S, Sakuma T, Yamamoto T, Arie T, Kuwata S
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: - Issue: 7 Pages: 1335-1342
- DOI
  10.1002/bit.25559
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24580070, KAKENHI-PROJECT-25890014
[Journal Article] Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes2015
- Author(s)
  Nakagawa Y, Sakuma T, Sakamoto T, Ohmuraya M, Nakagata N, Yamamoto T
- Journal Title
  
  BMC Biotechnol
  
  Volume: - Issue: 1 Pages: 33-33
- DOI
  10.1186/s12896-015-0144-x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-15H04606
[Journal Article] Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas92015
- Author(s)
  Hara S, Tamano M, Yamashita S, Kato T, Saito T, Sakuma T, Yamamoto T, Inui M, Takada S
- Journal Title
  
  Sci Rep
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Unliganded thyroid hormone receptor alpha regulates developmental timing via gene repression in Xenopus tropicalis2015
- Author(s)
  J. Choi, K. T. Suzuki, T. Sakuma, L. Shewade, T. Yamamoto and D. R. Buchholz
- Journal Title
  
  Endocrinology
  
  Volume: 156 Issue: 2 Pages: 735-44
- DOI
  10.1210/en.2014-1554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient iPS Cells by TALEN and CRISPR-Cas92015
- Author(s)
  Hongmei Lisa Li
- Journal Title
  
  Stem Cell Reports
  
  Volume: 4 Issue: 1 Pages: 143-154
- DOI
  10.1016/j.stemcr.2014.10.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J01936, KAKENHI-PROJECT-25860236, KAKENHI-PROJECT-25890014
[Journal Article] Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editing2014
- Author(s)
  Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M, Yamamoto T
- Journal Title
  
  Exp Anim
  
  Volume: -
- NAID
  130004677827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Versatile strategy for isolating TALEN-mediated knockout mutants in Caenorhabditis elegans.2014
- Author(s)
  Sugi T, Sakuma T, Ohtani T and Yamamoto T
- Journal Title
  
  Dev Growth Differ
  
  Volume: 56 Issue: 1 Pages: 78-85
- DOI
  10.1111/dgd.12108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25840124, KAKENHI-PROJECT-25890014
[Journal Article] TALEN-induced gene knock out in Drosophila.2014
- Author(s)
  Kondo T
- Journal Title
  
  Development Growth and Differentiation
  
  Volume: 56:1 Issue: 1 Pages: 86-91
- DOI
  10.1111/dgd.12097
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.2014
- Author(s)
  Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K
- Journal Title
  
  J Cell Biol.
  
  Volume: 206 Issue: 3 Pages: 347-356
- DOI
  10.1083/jcb.201404075
- NAID
  120005468381
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26840065
[Journal Article] Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells2014
- Author(s)
  Ochiai, H., Sugawara, T., Sakuma, T., Yamamoto, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 7125-7125
- DOI
  10.1038/srep07125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830138, KAKENHI-PROJECT-25890014
[Journal Article] FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions2014
- Author(s)
  Tokumasu D, Sakuma T, Hayashi Y, Hosoi S, Hiyama E, Yamamoto T
- Journal Title
  
  Genes to Cells
  
  Volume: 19 Issue: 5 Pages: 419-431
- DOI
  10.1111/gtc.12142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23256006, KAKENHI-PROJECT-24249084, KAKENHI-PROJECT-25293359, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26670764
[Journal Article] Targeted mutagenesis in sea urchin embryos using TALENs.2014
- Author(s)
  Hosoi S, Sakuma T, Sakamoto N and Yamamoto T
- Journal Title
  
  Dev Growth Differ
  
  Volume: 56 Issue: 1 Pages: 92-97
- DOI
  10.1111/dgd.12099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Germ cell mutations of the ascidian Ciona intestinalis with TALE nucleases.2014
- Author(s)
  Yoshida K, Treen N, Hozumi A, Sakuma T, Yamamoto T, Sasakura Y.
- Journal Title
  
  Genesis
  
  Volume: in press Issue: 5 Pages: 431-439
- DOI
  10.1002/dvg.22770
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Screening Methods to Identify TALEN-Mediated Knockout Mice2014
- Author(s)
  Nakagawa Y, Yamamoto T, Suzuki KI, Araki K, Takeda N, Ohmuraya M, Sakuma T
- Journal Title
  
  Exp. Anim.
  
  Volume: 63 Issue: 1 Pages: 79-84
- DOI
  10.1538/expanim.63.79
- NAID
  130003391606
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25890014
[Journal Article] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems2014
- Author(s)
  A. Yasue, S. N. Mitsui, T. Watanabe, T. Sakuma, S. Oyadomari, T. Yamamoto, S. Noji, T. Mito and E. Tanaka
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 5705-5705
- DOI
  10.1038/srep05705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-25463184, KAKENHI-PROJECT-25650080, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26293436, KAKENHI-PROJECT-26670270, KAKENHI-PROJECT-26870415
[Journal Article] Tissue-specific and ubiquitous gene knockouts in Ciona by electroporating TALENs provide new approaches to investigate gene functions2014
- Author(s)
  Treen, N., Yoshida, K., Sakuma, T., Sasaki, H., Kawai, N., Yamamoto, T., Sasakura, Y.
- Journal Title
  
  Development
  
  Volume: 141 Issue: 2 Pages: 481-487
- DOI
  10.1242/dev.099572
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
[Journal Article] Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration.2014
- Author(s)
  Hayashi T, Sakamoto K, Sakuma T, Yokotani N, Inoue T, Kawaguchi E, Agata K, Yamamoto T, Takeuchi T
- Journal Title
  
  Development, Growth and Differentiation
  
  Volume: 56 Issue: 1 Pages: 115-121
- DOI
  10.1111/dgd.12103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PLANNED-22124002, KAKENHI-PROJECT-24657155, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113520, KAKENHI-PUBLICLY-25124706, KAKENHI-PROJECT-25840086, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26650082
[Journal Article] Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of transcription activator-like effector nucleases2014
- Author(s)
  Sakane, Y., Sakuma, T., Kashiwagi, K., Kashiwagi, A., Yamamoto, T. and Suzuki, K. T.
- Journal Title
  
  Dev Growth Differ
  
  Volume: 56(1) Issue: 1 Pages: 108-114
- DOI
  10.1111/dgd.12105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21221004, KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
[Journal Article] Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex2014
- Author(s)
  Chizue Hiruta, Yukiko Ogino, Tetsushi Sakuma, Kenji Toyota, Shinichi Miyagawa, Takashi Yamamoto, Taisen Iguchi
- Journal Title
  
  BMC Biotechnology
  
  Volume: 14 Issue: 1 Pages: 95-95
- DOI
  10.1186/s12896-014-0095-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J04065, KAKENHI-PROJECT-12J05579, KAKENHI-PROJECT-24370029, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26840115
[Journal Article] Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas92014
- Author(s)
  S. Nakade, T. Tsubota, Y. Sakane, S. Kume, N. Sakamoto, M. Obara, T. Daimon, H. Sezutsu, T. Yamamoto, T. Sakuma and K. T. Suzuki
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 5560-5560
- DOI
  10.1038/ncomms6560
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23688008, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25292202, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290070
[Journal Article] Simple knockout by electroporation of engineered endonucleases into intact rat embryos2014
- Author(s)
  Kaneko T, Sakuma T, Yamamoto T, Mashimo T
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 6382-6382
- DOI
  10.1038/srep06382
- NAID
  120005477670
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290033
[Journal Article] Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies2014
- Author(s)
  Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M
- Journal Title
  
  Scientific reports
  
  Volume: 4 Issue: 1 Pages: 6136-6136
- DOI
  10.1038/srep06136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-25640044, KAKENHI-PROJECT-25713037, KAKENHI-PROJECT-25890014
[Journal Article] TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.2014
- Author(s)
  Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111(4) Issue: 4 Pages: 1461-6
- DOI
  10.1073/pnas.1317008111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113521, KAKENHI-PROJECT-25830138, KAKENHI-PROJECT-25890014
[Journal Article] Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system2014
- Author(s)
  Sakuma T, Nishikawa A, Kume S, Chayama K, Yamamoto T
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 5400-5400
- DOI
  10.1038/srep05400
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26670383
[Journal Article] Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato2014
- Author(s)
  Sawai, S., Ohyama, K., Yasumoto, S., Seki, H., Sakuma, T., Yamamoto, T., Takebayashi, Y., Kojima, M., Sakakibara, H., Aoki, T., Muranaka, T., Saito, K., Umemoto, N.
- Journal Title
  
  The Plant Cell
  
  Volume: 26 Issue: 9 Pages: 3763-3774
- DOI
  10.1105/tpc.114.130096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J00525, KAKENHI-PROJECT-25890014
[Journal Article] Nuclease-mediated genome editing: At the front-line of functional genomics technology.2014
- Author(s)
  Sakuma, T., and Woltjen, K.
- Journal Title
  
  Development, growth & differentiation
  
  Volume: 56 Issue: 1 Pages: 2-13
- DOI
  10.1111/dgd.12111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710240, KAKENHI-PROJECT-25890014
[Journal Article] Production of Sry knockout mouse using TALEN via oocyte injection.2013
- Author(s)
  Kato T, Miyata K, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, Asahara H, Takada S.
- Journal Title
  
  Scientific reports
  
  Volume: 3 Issue: 1 Pages: 3136-3136
- DOI
  10.1038/srep03136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570265, KAKENHI-PUBLICLY-24115707, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24657156, KAKENHI-PLANNED-25118007, KAKENHI-PUBLICLY-25132713, KAKENHI-PROJECT-25890014
[Journal Article] Efficient TALEN construction and evaluation methods for human cell and animal applications.2013
- Author(s)
  Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
- Journal Title
  
  Genes to Cells
  
  Volume: (In press) Issue: 4 Pages: 315-326
- DOI
  10.1111/gtc.12037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02843, KAKENHI-PROJECT-12J06938, KAKENHI-PLANNED-21112004, KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-23710240, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156
[Journal Article] Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.2013
- Author(s)
  Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 3379-3379
- DOI
  10.1038/srep03379
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-24700427, KAKENHI-PUBLICLY-25113521, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
[Journal Article] 人工ヌクレアーゼを用いたゲノム編集2012
- Author(s)
  佐久間哲史
- Journal Title
  
  Medical Science Digest
  
  Volume: 38 Pages: 328-329
- Data Source
  KAKENHI-PROJECT-12J06938
[Patent] 標的遺伝子にエフェクタータンパク質を集積するための組成物、およびその利用2018
- Inventor(s)
  山本卓、佐久間哲史、國井厚志
- Industrial Property Rights Holder
  国立大学法人広島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-041322
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K18478
[Patent] 標的遺伝子にエフェクタータンパク質を集積するための組成物、およびその利用2018
- Inventor(s)
  山本卓、佐久間哲史、國井厚志
- Industrial Property Rights Holder
  山本卓、佐久間哲史、國井厚志
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H01409
[Patent] 核酸挿入用ベクター2013
- Inventor(s)
  鈴木賢一、坂根祐人、佐久間哲史、山本卓
- Industrial Property Rights Holder
  国立大学法人広島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-230349
- Filing Date
  2013-11-06
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Nuclear base editing in human cells by the cooperation of novel single-molecule nickase and deaminase fused with TAL effectors2024
- Author(s)
  Tetsushi Sakuma, Nahoko Nishibori, Hina Kubota, Tadahiko Yoshima
- Organizer
  KEYSTONE SYMPOSIA - PRECISION GENOME ENGINEERING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] ゲノム編集技術の現状と2050年展望2024
- Author(s)
  佐久間　哲史
- Organizer
  日本生物工学会創立100周年記念シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] High-performance transcriptional activation using Class 1 Type I-E CRISPR system2024
- Author(s)
  Maya Oko, Atsushi Kunii, Kazuto Yoshimi, Tomoji Mashimo, Tetsushi Sakuma
- Organizer
  KEYSTONE SYMPOSIA - PRECISION GENOME ENGINEERING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] CRISPR-Cascadeを用いた高機能転写活性化システムの開発2023
- Author(s)
  大古　真矢、國井　厚志、吉見　一人、真下　知士、佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] CRISPRaic: simultaneous, orthogonal, and high-efficiency control of the activation and repression of transcription and DNA cleavage2023
- Author(s)
  Shunichiro Usui, Atsushi Kunii, Tetsushi Sakuma
- Organizer
  JAACT2023 Nogoya
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 拡張型LoADシステムを用いたゲノム編集結果の制御技術の開発2023
- Author(s)
  西川　想大、佐藤　瑞貴、佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Development and optimization of CRISPR-Cas3-mediated gene knock-in technology2023
- Author(s)
  Daiki Nagatomo, Kazuto Yoshimi, Tomoji Mashimo, Tetsushi Sakuma
- Organizer
  JAACT2023 Nogoya
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 転写の活性化、抑制およびDNA切断を同時制御するCRISPRaicシステムの開発2023
- Author(s)
  宇吹　俊一郎、國井　厚志、佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Two-pronged approach to genome editing and transcriptional control using CRISPR-Cas9/Cas12a and CRISPR-Cascade/Cas32023
- Author(s)
  Tetsushi Sakuma
- Organizer
  16th International Symposium on Nanomedicine (ISNM2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Simultaneous, orthogonal, and high-efficiency control of the activation and repression of transcription and DNA cleavage by CRISPRaic system2023
- Author(s)
  Shunichiro Usui, Atsushi Kunii, Tetsushi Sakuma
- Organizer
  Frontiers in Genome Engineering 2023 (FGE2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Efficient genome engineering with controllable editing outcomes through expansion of the LoAD system2023
- Author(s)
  Sota Nishikawa, Mizuki Sato, Tetsushi Sakuma
- Organizer
  16th International Symposium on Nanomedicine (ISNM2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] DNAポリメラーゼを用いたCas9およびCas12aにより誘発される変異パターンの制御技術の開発2023
- Author(s)
  塩田　千空、中出　翔太、中前　和恭、Lu Timothy K.、佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 長鎖欠失ツールCRISPR-Cas3を用いた遺伝子ノックイン技術の開発2023
- Author(s)
  永友　大暉、吉見　一人、真下　知士、佐久間　哲史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 新規単分子ニッカーゼとデアミナーゼの協働によるCas9非依存型核ゲノム塩基編集技術の開発2023
- Author(s)
  佐久間　哲史、西堀　奈穂子、久保田　日菜、吉間　忠彦
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] CRISPR-Cas3を用いた遺伝子ノックインの最適化2023
- Author(s)
  永友　大暉、吉見　一人、真下　知士、佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 多様化するゲノム編集の“今”2023
- Author(s)
  佐久間　哲史
- Organizer
  日本ゲノム編集学会第8回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] CRISPRaic：転写の活性化、抑制およびDNA切断を同時制御可能なシステムの開発と応用2023
- Author(s)
  宇吹　俊一郎、國井　厚志、佐久間　哲史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] DNAポリメラーゼはCas9およびCas12aにより誘発される変異パターンの制御を可能にする2023
- Author(s)
  塩田　千空、中出　翔太、中前　和恭、Lu Timothy K.、佐久間　哲史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Development of a high-performance transcriptional activation system using Class 1 CRISPR system2023
- Author(s)
  Maya Oko, Atsushi Kunii, Kazuto Yoshimi, Tomoji Mashimo, Tetsushi Sakuma
- Organizer
  JAACT2023 Nogoya
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] LoADシステムの拡張がゲノム編集結果に高度なバイアスをかける2023
- Author(s)
  西川　想大、佐藤　瑞貴、佐久間　哲史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 多様化するゲノム編集の基盤技術開発2023
- Author(s)
  佐久間　哲史
- Organizer
  神戸大学学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] CRISPR-free Nuclear Base Editing by the Cooperation of Novel Single-molecule Nickase and Deaminase Fused with TAL Effectors2023
- Author(s)
  Tetsushi Sakuma, Nahoko Nishibori, Hina Kubota, Tadahiko Yoshima
- Organizer
  JAACT2023 Nogoya
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] TALE-based nuclear base editing by the cooperation of novel single-molecule nickase and deaminase2023
- Author(s)
  Tetsushi Sakuma, Nahoko Nishibori, Hina Kubota, Tadahiko Yoshima
- Organizer
  Frontiers in Genome Engineering 2023 (FGE2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Expansion of the LoAD system for efficient genome engineering by strongly biasing the editing outcomes2023
- Author(s)
  Sota Nishikawa, Mizuki Sato, Tetsushi Sakuma
- Organizer
  JAACT2023 Nogoya
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Highly specific and efficient C-to-T and A-to-G base editing with TALE-deaminases assisted by Type I or Type II CRISPR systems2022
- Author(s)
  Tetsushi Sakuma, Nahoko Nishibori, Tadahiko Yoshima, Takashi Yamamoto
- Organizer
  Cold Spring Harbor Laboratory Meeting - Genome engineering: CRISPR frontiers
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] From nuclease-based genome editing to DNA double-strand break-free precision gene engineering2022
- Author(s)
  Tetsushi Sakuma
- Organizer
  15th International Symposium on Nanomedicine (ISNM2022)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 最先鋭ゲノム編集の現在地2022
- Author(s)
  佐久間哲史
- Organizer
  日本ゲノム編集学会第7回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Highly specific and efficient C-to-T and A-to-G base editing by Cas9 and TALE cooperation2022
- Author(s)
  Tetsushi Sakuma, Nahoko Nishibori, Tadahiko Yoshima, Takashi Yamamoto
- Organizer
  FASEB Science Research Conference - The Genome Engineering Conference: Cutting-edge Research and Applications
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Cas9とTALEの協働によるC→TおよびA→Gの特異的で高効率な塩基編集2022
- Author(s)
  佐久間哲史, 西堀奈穂子, 吉間忠彦, 山本卓
- Organizer
  日本ゲノム編集学会第7回大会
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] ゲノム編集の最新動向と今後の展望2021
- Author(s)
  佐久間哲史
- Organizer
  第６回川島カンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] Recent advances in genome editing and beyond2021
- Author(s)
  Tetsushi Sakuma
- Organizer
  14th International Symposium on Nanomedicine (ISNM2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] 培養細胞を用いたゲノム編集研究の最前線2021
- Author(s)
  佐久間哲史
- Organizer
  日本ゲノム編集学会第6回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06137
[Presentation] ゲノム編集技術update -2021-2021
- Author(s)
  佐久間哲史
- Organizer
  日本ゲノム編集学会会員特別セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] Development of transcriptional activation platforms of cancer-related genes using Class 1 and Class 2 CRISPR systems2020
- Author(s)
  Tetsushi Sakuma
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] ゲノム編集技術の現状と将来2020
- Author(s)
  佐久間哲史
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] ゲノム編集および関連技術の最新開発動向2019
- Author(s)
  佐久間哲史
- Organizer
  第442回川崎医学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] 最先端バイオテクノロジー “ゲノム編集”の研究開発動向2019
- Author(s)
  佐久間哲史
- Organizer
  令和元年度広島バイオフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] ゲノム編集および関連技術の最新開発動向2019
- Author(s)
  佐久間哲史
- Organizer
  第60回日本生化学会中国・四国支部例会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16111
[Presentation] Biased genome editing using the LoAD (local accumulation of DSB repair molecules) system2018
- Author(s)
  Tetsushi Sakuma, Shota Nakade, Keiji Mochida, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, and Takashi Yamamoto
- Organizer
  Precision Genome Editing with Programmable Nucleases - Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Parallel generation of multiplex knock-in cell collections using CRISPR-Cas9 assisted by locally enhanced MMEJ2018
- Author(s)
  Tetsushi Sakuma, Shota Nakade, Keiji Mochida, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, and Takashi Yamamoto
- Organizer
  The 9th Takeda Science Foundation Symposium on PharmaSciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Concurrent MMEJ-assisted fusional knock-in of long gene cassette in human cells and mouse embryos2018
- Author(s)
  Sakuma T et al.
- Organizer
  Keystone Symposia Conference _ Genome Engineering
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01409
[Presentation] Cas9 RNP導入細胞のクローン化に伴うheterogeneityの解析2017
- Author(s)
  佐久間哲史、持田圭次、中出翔太、江連徹、皆川吉、山本卓
- Organizer
  日本ゲノム編集学会第２回大会
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Highly practical gene knock-in in mammalian cells and zygotes with MMEJ-dependent strategy2017
- Author(s)
  Tetsushi Sakuma
- Organizer
  2nd Annual Genome Editing & Engineering Conference
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2017-02-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎恭之、竹尾透、山本卓、中潟直己
- Organizer
  第2回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] がん抑制およびがんモデリングのための人工転写調節技術の開発2017
- Author(s)
  佐久間哲史
- Organizer
  第２回日本遺伝子細胞治療学会若手研究会セミナー
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Recent advances in genome editing technology2017
- Author(s)
  Tetsushi Sakuma
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy (JSGCT2017)
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Updated summary of genome editing technology2017
- Author(s)
  Tetsushi Sakuma
- Organizer
  11th International Symposium on Nanomedicine (ISNM2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Recent Development and Application of Genome Editing Tools and Methods2017
- Author(s)
  Tetsushi Sakuma
- Organizer
  The 20th US-Japan Cellular and Gene Therapy Conference, CRISPR/Cas9 Gene Editing In Vivo
- Place of Presentation
  Silver Spring, MD, USA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎恭之、若松和子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、石田恵理、坂本亘、土山修治、竹尾　透、山本　卓、中潟直己
- Organizer
  第64回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] Recent advances in gene knock-in techniques for cultured cell engineering2017
- Author(s)
  Tetsushi Sakuma, Shota Nakade, and Takashi Yamamoto
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Cas9によるゲノム編集とヒト疾患解析・治療への応用2017
- Author(s)
  佐久間哲史
- Organizer
  第57回日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017
- Author(s)
  中川佳子、佐久間哲史、西道教尚、横崎泰之、近藤朋子、竹下由美、中牟田裕子、石田恵理、坂本亘、土山修治、竹尾　透、山本　卓、中潟直己
- Organizer
  第35回動物生殖工学研究会
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ゲノム編集の技術開発と培養細胞での利用2017
- Author(s)
  佐久間哲史
- Organizer
  日本ゲノム編集学会第２回大会
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] Advanced method to generate gene cassette knock-in and floxed mice using the PITCh system facilitated with MMEJ enhancer2017
- Author(s)
  Tetsushi Sakuma, Tomomi Aida, Shota Nakade, Takashi Yamamoto, Kohichi Tanaka
- Organizer
  Keystone Symposia, Precision Genome Engineering
- Place of Presentation
  Breckenridge, CO, USA
- Year and Date
  2017-01-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集技術を用いた鎖骨頭蓋異形成症モデルマウスの作成2017
- Author(s)
  吉本由紀、森　健吾、星野　麻里、田中　誠真、渡邊　仁美、佐久間　哲史、山下　寛、岡本　哲治、近藤　玄、山本　卓、開　祐司、宿南　知佐
- Organizer
  日本ゲノム編集学会第2回大会
- Data Source
  KAKENHI-PROJECT-16K15780
[Presentation] Culture time of zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017
- Author(s)
  Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, and Takashi Yamamoto
- Organizer
  2nd annual Genome Editing & Engineering Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] MMEJ-directed gene cassette knock-in in mammalian cells and zygotes2016
- Author(s)
  Tetsushi Sakuma, Shota Nakade, Tomomi Aida, Kohichi Tanaka, Takashi Yamamoto
- Organizer
  FASEB Science Research Conference, Genome Engineering - Cutting-Edge Research and Applications
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムによる遺伝子破壊マウスの作製－超過剰排卵誘起法を用いた凍結受精卵の利用－2016
- Author(s)
  中川佳子、佐久間哲史、坂本拓弥、山本卓、若松和子、山下紀代子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、梅野智子、宮川あい、土山修治、竹尾透、中潟直己
- Organizer
  第63回日本実験動物学会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] ゲノム編集の最新技術2016
- Author(s)
  佐久間哲史
- Organizer
  Skeletal Science Retreat 骨代謝スクール
- Place of Presentation
  熱海
- Year and Date
  2016-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集による遺伝子改変の最前線2016
- Author(s)
  佐久間哲史
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集の基礎と最新動向2016
- Author(s)
  佐久間哲史
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集の最新方法論2016
- Author(s)
  佐久間哲史
- Organizer
  DNA鑑定学会第9回大会
- Place of Presentation
  東京
- Year and Date
  2016-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムによる様々なゲノム編集個体の作製―超過剰排卵誘起法を用いた体外受精凍結卵の利用2016
- Author(s)
  中川佳子，佐久間哲史，西道教尚，横崎恭之，矢中規之，竹尾透，中潟直己，山本卓
- Organizer
  第一回ゲノム編集学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] Current advances and future prospects of genome editing technology2016
- Author(s)
  Tetsushi Sakuma
- Organizer
  10th International Symposium on Nanomedicine (ISNM2016)
- Place of Presentation
  つくば
- Year and Date
  2016-11-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] CRISPR-Casシステムによるfloxマウスの作製－超過剰排卵誘起法を用いた凍結受精卵の利用－2016
- Author(s)
  中川佳子、佐久間哲史、矢中規之、山本卓、若松和子、山下紀代子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、梅野智子、土山修治、竹尾　透、中潟直己
- Organizer
  第50回日本実験動物技術者協会総会
- Place of Presentation
  ウェスタ川越（埼玉県川越市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] Highly practical gene cassette knock-in in mammalian cells and zygotes mediated by MMEJ2016
- Author(s)
  Tetsushi Sakuma, Tomomi Aida, Shota Nakade, Kohichi Tanaka, Takashi Yamamoto
- Organizer
  Cold Spring Harbor Laboratory Meeting, Genome Engineering: The CRISPR-Cas Revolution
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2016-08-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集の最新方法論2016
- Author(s)
  佐久間哲史
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山
- Year and Date
  2016-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-16K18478
[Presentation] ゲノム編集の最前線と合成生物学への展開2015
- Author(s)
  佐久間哲史
- Organizer
  2015アジレントゲノミクスフォーラム
- Place of Presentation
  東京
- Year and Date
  2015-06-16
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 凍結受精卵を用いたCRISPR/Cas9システムによる遺伝子破壊マウスの作製2015
- Author(s)
  中川佳子、佐久間哲史、坂本拓弥、大村谷昌樹、山本卓、中潟直己
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15H04606
[Presentation] Platinum TALENおよびマルチガイドCRISPRシステムを用いたゲノム編集2015
- Author(s)
  佐久間哲史
- Organizer
  ゲノム編集マウスワークショップ
- Place of Presentation
  つくば
- Year and Date
  2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Genome editing using Platinum TALENs2014
- Author(s)
  Takashi Yamamoto, Ken-ichi Suzuki, Tetsushi Sakuma
- Organizer
  第47回日本発生生物学会大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using TALENs2014
- Author(s)
  Ken-ichi T Suzuki, Yuto Sakane, Tetsushi Sakuma, Keiko Kashiwagi, Akihiko Kashiwagi, Takashi Yamamoto
- Organizer
  International Symposium on RNAi and Genome Editing Methods
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Platinum Gate TALEN system: Construction of highly-active Platinum TALENs2014
- Author(s)
  Tetsushi Sakuma, Takashi Yamamoto
- Organizer
  International Symposium on RNAi and Genome Editing Methods
- Place of Presentation
  徳島
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Knockout of genes in the chordate Ciona intestinalis2014
- Author(s)
  Nicholas Treen, Haruka Sasaki, Keita Yoshida, Akiko Hozumi, Tetsushi Sakuma, Takashi Yamamoto, Yasunori Sasakura
- Organizer
  第47回日本発生生物学会大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Genome editing with TALENs and Crispr/Cas9 in the ascidian Ciona intestinalis2014
- Author(s)
  Nicholas Treen, Keita Yoshida, Haruka Sasaki, Tetsushi Sakuma, Narudo Kawai, Takashi Yamamoto, Yasunori Sasakura
- Organizer
  International Symposium on RNAi and Genome Editing Methods
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Quantitative analysis of chromatin dynamics and gene expression in murine embryonic stem cells2014
- Author(s)
  Hiroshi Ochiai, Takeshi Sugawara, Tetsushi Sakuma, Takashi Yamamoto
- Organizer
  第2回クロマチン動態数理研究拠点国際シンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 高活性型Platinum TALENを用いたゲノム編集2014
- Author(s)
  佐久間哲史
- Organizer
  第1回KBRPワークショップ
- Place of Presentation
  熊本
- Year and Date
  2014-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Highly efficient gene targeting in filamentous fungus Pyricularia oryzae by Platinum Gate TALEN system2014
- Author(s)
  Takayuki Arazoe, Tetsuya Younomaru, Shuichi Ohsato, Tetsushi Sakuma, Takashi Yamamoto, Tsutomu Arie, Shigeru Kuwata
- Organizer
  International Symposium on RNAi and Genome Editing Methods
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system2014
- Author(s)
  Akihiro Yasue, Silvia Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
- Organizer
  International Symposium on RNAi and Genome Editing Methods
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 人工ヌクレアーゼ TALEN によるトリテルペノイド生合成酵素遺伝子の破壊2014
- Author(s)
  安本周平、關光、福島エリオデット、佐久間哲史、山本卓、村中俊哉
- Organizer
  第55回日本植物生理学会年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] PPR motif as a new DNA/RNA binding module for genome editing2014
- Author(s)
  Yusuke Yagi, Tetsushi Sakuma, Takashi Yamamoto, Takahiro Nakamura
- Organizer
  第55回日本植物生理学会年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Front-line of genome editing technology in various animals2014
- Author(s)
  Tetsushi Sakuma
- Organizer
  2014 KALAS Winter Symposium
- Place of Presentation
  韓国
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 植物の新奇転写抑制モチーフ－真核生物に保存された転写抑制機構の解析－2014
- Author(s)
  伊藤岳、岡村僚太、佐久間哲史、山本卓、高橋陽介
- Organizer
  第55回日本植物生理学会年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 高活性型TALEN を用いたゲノム編集2013
- Author(s)
  山本卓、鈴木賢一、相田知海、田中光一、佐久間哲史
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] FAST-idシステム：TALENによる変異導入細胞および染色体領域欠失細胞の濃縮システムの開発2013
- Author(s)
  徳増大輔、佐久間哲史、林陽子、檜山英三、坂本尚昭、山本卓
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死の p53依存的な誘導機構の解明2013
- Author(s)
  香川晴信、河合秀彦、佐久間哲史、山本卓、塩谷文章、嶋本顕、田原栄俊
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いた受精卵内遺伝子改変による高効率ノックインマウス作製2013
- Author(s)
  相田知海、佐久間哲史、宇佐美貴子、石久保春美、今橋理沙、山本卓、田中光一
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Ascidian Genome Editing Using TALENs2013
- Author(s)
  Nicholas Treen, Keita Yoshida, Tetsushi Sakuma, Haruka Sasaki, Narudo Kawai, Takashi Yamamoto, Yasunori Sasakura
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Highly efficient knockin mouse production by TALEN-mediated in vivo genome editing2013
- Author(s)
  Tomomi Aida, Tetsushi Sakuma, Takako Usami, Harumi Ishikubo, Risa Imahashi, Takashi Yamamoto, Kohichi Tanaka
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] DNA・RNA編集の新しい核酸結合モジュール, PPRモチーフ2013
- Author(s)
  八木祐介、佐久間哲史、山本卓、中村崇裕
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] E-カドヘリンを発現しない上皮細胞の作製およびデスモソーム研究への応用2013
- Author(s)
  鈴木信太郎、藤村基人、藤原美和子、佐久間哲史、山本卓
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Platinum Gate TALEN: Establishment of highly-active TALEN construction system2013
- Author(s)
  Tetsushi Sakuma, Takashi Yamamoto
- Organizer
  Conference on Transposition and Genome Engineering 2013
- Place of Presentation
  ハンガリー
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 細胞増殖シグナル依存的な一次繊毛抑制過程におけるPLK1-KIF2A経路の役割2013
- Author(s)
  宮本達雄、細羽康介、落合博、佐久間哲史、山本卓、松浦伸也
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALEN RNAの受精卵へのマイクロインジェクションによるY連鎖遺伝子のノックアウトマウスの作製と解析2013
- Author(s)
  加藤朋子、宮田康平、園部未来、山下聡、玉野萌恵、宮本新吾、佐久間哲史、山本卓、乾雅史、菊水健史、浅原弘嗣、高田修治
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 人工ヌクレアーゼによる一塩基編集法を利用したPCS（MVA）症候群の遺伝子間領域変異の同定2013
- Author(s)
  松浦伸也、落合博、宮本達雄、金井昭教、細羽康介、佐久間哲史、浅見恵子、小川淳、渡辺輝浩、梶井正、山本卓
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  宮城
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 無尾両生類におけるゲノム編集2013
- Author(s)
  鈴木賢一、坂根祐人、佐久間哲史、坂本尚昭、柏木啓子、柏木昭彦、山本卓
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いたツメガエル発生過程におけるサイトグロビンの機能解析2013
- Author(s)
  中出翔太、鈴木賢一、佐久間哲史、重田美津紀、柏木昭彦、柏木啓子、山本卓、小原政信
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 高活性型Platinum TALENを用いた効率的なゲノム編集2013
- Author(s)
  佐久間哲史、山本卓
- Organizer
  第6回DNA鑑定学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 無尾両生類におけるTALENを用いた標的遺伝子の多重破壊の試み2013
- Author(s)
  坂根祐人、佐久間哲史、坂本尚昭、柏木啓子、柏木昭彦、山本卓、鈴木賢一
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 動物におけるゲノム編集技術の最前線2013
- Author(s)
  佐久間哲史
- Organizer
  第31回九州実験動物研究会総会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Identification of an extragenic mutation of BUB1B gene for PCS (MVA) syndrome and functional analysis using TAL effector nucleases2013
- Author(s)
  T. Miyamoto, H. Ochiai, A. Kanai, K. Hosoba, S. Kume, T. Sakuma, T. Yamamoto, S. Matsuura
- Organizer
  American Society of Human Genetics 2013 Annual Meeting
- Place of Presentation
  アメリカ
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 高活性型Platinum TALENの効率的な作製システムの開発2013
- Author(s)
  佐久間哲史、山本卓
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENによるイモリのゲノム編集の可能性と, 再生研究への展開2013
- Author(s)
  林利憲、坂本興亮、佐久間哲史、横谷直樹、井上武、川口恵里、阿形清和、山本卓、竹内隆
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 人工ヌクレアーゼTALENを用いたカタユウレイボヤの突然変異体系統の作製2013
- Author(s)
  吉田慶太、Treen Nicholas、保住暁子、佐久間哲史、山本卓、笹倉靖徳
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALEN技術を用いたSry KOマウスの作出2013
- Author(s)
  加藤朋子、宮田康平、園部未来、山下聡、玉野萌恵、宮本新吾、佐久間哲史、山本卓、乾雅史、菊水健史、浅原弘嗣、高田修治
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いたカタユウレイボヤ生殖細胞形成機構の解析2013
- Author(s)
  白江-倉林麻貴、佐久間哲史、笹倉靖徳、中村輝、山本卓
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system2013
- Author(s)
  Akihiro Yasue, Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 分裂期キネシンKIF2Aを介した細胞増殖に共役した繊毛退縮機構2013
- Author(s)
  宮本達雄、細羽康介、落合博、佐久間哲史、山本卓、松浦伸也
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALEN, CRISPR/Casシステムを用いたマウス１細胞期胚における標的遺伝子破壊2013
- Author(s)
  泰江章博、三井なおみ、渡辺崇人、佐久間哲史、親泊政一、山本卓、野地澄晴、三戸太郎、田中栄二
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集の新しいDNA/RNA結合モジュール、PPRモチーフ2013
- Author(s)
  八木祐介、佐久間哲史、山本卓、中村崇裕
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENsを利用した効率的なノックアウトマウスの作製について2013
- Author(s)
  中川佳子、佐久間哲史、黒田和子、吉松麗加、竹田直樹、佐々木賢一、山本卓、大村谷昌樹
- Organizer
  日本実験動物技術者協会第47回総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術を用いた霊長類疾患モデルの作製2013
- Author(s)
  岸憲幸、佐藤賢哉、佐久間哲史、奥野弥佐子、岡野ジェイムズ洋尚、山本卓、佐々木えりか、岡野栄之
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENの植物代謝工学研究への応用展開2013
- Author(s)
  村中俊哉、安本周平、關光、福島エリオデット、佐久間哲史、山本卓
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 染色体工学技術とゲノム編集技術によるヒト化モデル動物の作製2013
- Author(s)
  香月康宏、佐久間哲史、小林カオル、阿部智志、平林真澄、千葉寛、山本卓、押村光雄
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] FAST-idシステム：TALENによる変異導入細胞および染色体領域欠失細胞の濃縮システムの開発2013
- Author(s)
  徳増大輔、佐久間哲史、林陽子、檜山英三、山本卓
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いたゼブラフィッシュ母性効果遺伝子の機能解析2013
- Author(s)
  黒川大輔、川原敦雄、佐久間哲史、山本卓、赤坂甲治、相澤慎一
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Improved TALEN construction and evaluation methods for animal and human cell applications2012
- Author(s)
  Tetsushi Sakuma
- Organizer
  FASEB Science Research Conference Genome Engineering - Research & Applications
- Place of Presentation
  Lucca, Italy
- Year and Date
  2012-09-03
- Data Source
  KAKENHI-PROJECT-12J06938
[Presentation] Advanced methods for the construction, evaluation and application of TALENs2012
- Author(s)
  Tetsushi Sakuma
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2012-05-28
- Data Source
  KAKENHI-PROJECT-12J06938
[Presentation] 人工ヌクレアーゼを利用したゲノム編集研究の現状2012
- Author(s)
  佐久間哲史
- Organizer
  第2回ゲノム編集研究会
- Place of Presentation
  愛知県岡崎市
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-12J06938
[Presentation] Stochastic promoter activation affects gene expression variability in murine embryonic stem cells
- Author(s)
  Hiroshi Ochiai, Takeshi Sugawara, Ken-ichi Suzuki, Tetsushi Sakuma, Takashi Yamamoto
- Organizer
  Cold Spring Harbor Laboratory Conference
- Place of Presentation
  NY, USA
- Year and Date
  2014-08-19 – 2014-08-23
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of TALENs
- Author(s)
  Yuto Sakane, Tetsushi Sakuma, Keiko Kashiwagi , Akihiko Kashiwagi, Takashi Yamamoto, Ken-ichi T Suzuki
- Organizer
  15th International Xenopus Conference
- Place of Presentation
  CA, USA
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ヒト紡錘体形成チェックポイント欠損症における細胞増殖に共役した一次繊毛退縮制御の破綻による繊毛病発症機構
- Author(s)
  宮本達雄, 細羽康介, 落合博, Royba Ekaterina, 佐久間哲史, 山本卓, 松浦伸也
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] A new strategy for gene knock-in in Xenopus laevis using Platinum TALENs
- Author(s)
  Yuto Sakane, Tetsushi Sakuma, Miyuki Suzuki, Takashi Yamamoto, Ken-ichi Suzuki
- Organizer
  第47回日本発生生物学会
- Place of Presentation
  愛知
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術による簡便迅速かつ高効率な次世代染色体工学の開発
- Author(s)
  野村淳, 佐久間哲史, 神田暁史, 岸本恵子, 前田知花, 外丸祐介, 山本卓, 内匠透
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Increased or decreased expression of the ladybird bomeobox1 causes scoliosis in zebrafish
- Author(s)
  Long Guo, Hiroshi Yamashita, Tetsushi Sakuma, Ikuyo Kou, Aki Takimoto, Takashi Yamamoto, Taiji Adachi, Yuji Hiraki, Shiro Ikegawa, Chisa Shukunami
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] マウス胚性幹細胞におけるNanogプロモーターの確率的活性化が発現量の不均一性に影響する
- Author(s)
  落合博, 菅原武志, 佐久間哲史, 山本卓
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] In vivo monitoring of histone H3 lysine 9 acetylation using Mintbody transgenic Xenopus laevis during embryogenesis and tail regeneration
- Author(s)
  鈴木美有紀, 坂根祐人, 佐久間哲史, 坂本尚昭, 山本卓, 鈴木賢一
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Genome editing reveals a novel function of keratin in fin formation in X. laevis
- Author(s)
  Ken-ichi T. Suzuki, Keiko Kashiwagi, Tetsushi Sakuma, Akihiko Kashiwagi, Makoto Mochii, Takashi Yamamoto
- Organizer
  15th International Xenopus Conference
- Place of Presentation
  CA, USA
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Ultra-rapid and highly efficient in vivo genome editing in mice
- Author(s)
  Tomomi Aida, Tetsushi Sakuma, Takako Usami, Harumi Ishikubo, Risa Imahashi, Keiho Chiyo, Pawel Obrocki, Takashi Yamamoto, Kohichi Tanaka
- Organizer
  FASEB Science Research Conference: Genome Engineering - Cutting-Edge Research and Applications
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ヒト培養細胞におけるMMEJを利用した汎用的な遺伝子ノックイン法の確立
- Author(s)
  中出翔太, 佐久間哲史, 坂本尚昭, 鈴木賢一, 山本卓
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Vectors for TALEN- and CRISPR/Cas9-mediated genome editing
- Author(s)
  Tetsushi Sakuma
- Organizer
  第21回日本遺伝子治療学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-07-24 – 2015-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Targeted genome editing using Platinum TALENs
- Author(s)
  Takashi Yamamoto, Kenichi Suzuki, Tetsushi Sakuma
- Organizer
  第47回日本発生生物学会
- Place of Presentation
  愛知
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いたジャガイモグリコアルカロイド生合成酵素遺伝子の破壊
- Author(s)
  安本周平, 關光, 澤井学, 大山清, 梅基直行, 佐久間哲史, 山本卓, 斉藤和希, 村中俊哉
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems
- Author(s)
  Akihiro Yasue, Silvia N. Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
- Organizer
  X Meeting Spanish Society for Developmental Biology
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-10-13 – 2014-10-15
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 有用なモデル動物となり得る、イベリアトゲイモリを用いた遺伝子操作法の確立
- Author(s)
  林利憲, 茗荷あゆみ, 佐久間哲史, 亀井保博, 横山仁, 山本卓, 竹内隆
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Platinum TALENおよびCRISPRマルチガイドシステムを用いたゲノム編集
- Author(s)
  佐久間哲史, 中出翔太, 坂本尚昭, 鈴木賢一, 山本卓
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Front-line of genome engineering technologies
- Author(s)
  Tetsushi Sakuma
- Organizer
  The 27th Annual Meeting of Japanese Association for Animal Cell Technology
- Place of Presentation
  北九州
- Year and Date
  2014-11-11 – 2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENによる効率的な遺伝子破壊マウスの作製―体外受精により得られた凍結受精卵の使用と採卵に用いる雌マウスの週齢検討―
- Author(s)
  中川佳子, 佐久間哲史, 中潟直己, 大村谷昌樹, 山本卓
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いた麹菌Aspergillus oryzaeにおけるゲノム編集
- Author(s)
  水谷治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本卓, 桑田茂, 山田修
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集のHIVへの応用
- Author(s)
  蝦名博貴, 金村優香, 三沢尚子, 佐久間哲史, 小林朋子, 山本卓, 小柳義夫
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術をもちいた培養精子幹細胞株の遺伝子改変
- Author(s)
  佐藤卓也, 佐久間哲史, 片桐久美子, 越後貫成美, 小倉淳郎, 山本卓, 小川毅彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] グルタミン酸トランスポーターGLASTのヒトレアバリアントは網膜神経節細胞の脆弱性にin vivoで寄与する
- Author(s)
  今橋里沙, 相田知海, 柳澤美智子, 佐久間哲史, 宇佐美貴子, 石久保春美, 山本卓, 田中光一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Analysis of the effect on HBV life cycle by HBV genome editing using TALEN and CRISPR/Cas9 system
- Author(s)
  Hiromi Abe, Tetsushi Sakuma, Masataka Tsuge, Nobuhiko Hiraga, Michio Imamura, Nelson Hayes, Hiroshi Aikata, Takashi Yamamoto, Kazuaki Chayama
- Organizer
  AASLD The Liver Meeting 2014
- Place of Presentation
  MA, USA
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] CRISPR/Casによるノックインマウス作製の効率化
- Author(s)
  相田知海, Keiho Chiyo, 佐久間哲史, 宇佐美貴子, 石久保春美, 今橋里沙, 田中謙二, 山本卓, 田中光一
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Functional analysis of Oct60 in adult organ formation of Xenopus laevis
- Author(s)
  Naoto Ito, Tetsushi Sakuma, Takashi Yamamoto, Tsutomu Kinoshita
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Front-line of genome editing technology for animal cell engineering
- Author(s)
  Tetsushi Sakuma
- Organizer
  The 24th Meeting of the European Society for Animal Cell Technology
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-05-31 – 2015-06-03
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術を用いた鳥類性決定関連遺伝子の解析
- Author(s)
  枡岡久子, 中川祐樹, 江崎僚, 佐久間哲史, 黒岩麻里, 山本卓, 堀内浩幸
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集によるMMEJを利用した汎用的な遺伝子ノックイン法の確立
- Author(s)
  中出翔太, 坂根祐人, 佐久間哲史, 小原政信, 鈴木賢一, 山本卓
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Platinum TALENによる高速・高効率なノックインマウス作製とヒトゲノム多様性の個体レベルでの機能解釈
- Author(s)
  今橋里沙, 相田知海, 柳澤美智子, 佐久間哲史, 宇佐美貴子, 石久保春美, 山本卓, 田中光一
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Unliganded thyroid hormone receptor alpha regulates gene repression and developmental timing as revealed by gene knockout in Xenopus tropicalis
- Author(s)
  Jinyoung Choi, Ken-ichi Suzuki, Tetsushi Sakuma, Leena Shewade, Takashi Yamamoto, Daniel R. Buchholz
- Organizer
  15th International Xenopus Conference
- Place of Presentation
  CA, USA
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALENを用いたメダカの環境依存的性決定機構の解析
- Author(s)
  竹中亨彰, 濱崎心, 内村友哉, 長船奈津美, 高木久徳, 佐久間哲史, 山本卓, 北野健
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Identification of Sterol Side Chain Reductase 2 (SSR2), a Key Enzyme in the Biosynthesis of Cholesterol As the Common Precursor of Toxic Steroidal Glycoalkaloids in Potato
- Author(s)
  Kazuki Saito, Satoru Sawai, Kiyoshi Ohyama, Shuhei Yasumoto, Hikaru Seki, Tetsushi Sakuma, Takashi Yamamoto, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Toshio Aoki, Toshiya Muranaka, Naoyuki Umemoto
- Organizer
  International Plant & Animal Genome XXIII
- Place of Presentation
  CA, USA
- Year and Date
  2015-01-10 – 2015-01-14
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Gene expression and function of Oct91 during lateral line formation in Xenopus laevis
- Author(s)
  Aya Amakawa, Tetsushi Sakuma, Takashi Yamamoto, Tsutomu Kinoshita
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] CRISPR/Cas9 システムを用いた精巧な遺伝子導入技術の開発
- Author(s)
  久野悠, 佐久間哲史, 太田聡, 王賀理恵, 岡本仁, 山本卓, 川原敦雄
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] PITCh systems: MMEJ-assisted gene knockin in human cells using TALENs and CRISPR/Cas9
- Author(s)
  Tetsushi Sakuma, Shota Nakade, Yuto Sakane, Ken-ichi T Suzuki, Takashi Yamamoto
- Organizer
  CRISPR Precision Gene Editing Congress
- Place of Presentation
  MA, USA
- Year and Date
  2015-02-25 – 2015-02-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] MMEJ-mediated integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
- Author(s)
  Shota Nakade, Takuya Tsubota, Yuto Sakane, Satoshi Kume, Naoaki Sakamoto, Masanobu Obara, Takaaki Daimon, Hideki Sezutsu, Takashi Yamamoto, Tetsushi Sakuma, Ken-ichi T. Suzuki
- Organizer
  Keystone Symposia: Precision Genome Engineering and Synthetic Biology
- Place of Presentation
  MT, USA
- Year and Date
  2015-01-11 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] アフリカツメガエルにおけるTALENを用いた標的遺伝子の改変
- Author(s)
  坂根祐人, 佐久間哲史, 鈴木美有紀, 柏木啓子, 柏木昭彦, 坂本尚昭, 山本卓, 鈴木賢一
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Knockout of genes in the chordate Ciona intestinalis
- Author(s)
  Nicholas Treen, Haruka Sasaki, Keita Yoshida, Akiko Hozumi, Tetsushi Sakuma, Takashi Yamamoto, Yasunori Sasakura
- Organizer
  第47回日本発生生物学会
- Place of Presentation
  愛知
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 核の凝縮機構の解析ー無細胞アポトーシス系を用いて
- Author(s)
  刀祢重信, 杉本憲治, 網代廣三, 佐久間哲史, 山本卓, 栗林太
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術をもちいた培養精子幹細胞株の遺伝子改変法の開発
- Author(s)
  佐藤卓也, 佐久間哲史, 片桐久美子, 越後貫成美, 小倉淳郎, 山本卓, 小川毅彦
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ミジンコ（Daphnia pulex）におけるPlatinum TALENを用いた標的遺伝子破壊法の確立
- Author(s)
  蛭田千鶴江, 荻野由紀子, 佐久間哲史, 豊田賢治, 山本卓, 井口泰泉
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 一塩基置換導入法による高発がん性遺伝病の変異の特定
- Author(s)
  落合博, 宮本達雄, 佐久間哲史, 山本卓, 松浦伸也
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術を用いた遺伝子改変ラット作製の現状
- Author(s)
  金子武人, 佐久間哲史, 山本卓, 真下知士
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ツメガエルにおける簡便なノックイン技術の確立:PITChシステム
- Author(s)
  鈴木賢一, 坂根祐人, 佐久間哲史, 山本卓
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Unliganded thyroid hormone receptor alpha regulates tissue sensitivity and gene repression as revealed by gene knockout in Xenopus tropicalis
- Author(s)
  Jinyoung Choi, Ken-ichi T. Suzuki, Tetsushi Sakuma, Leena Shewade, Takashi Yamamoto, Daniel R. Buchholz
- Organizer
  6th Great Lakes Nuclear Receptor Conference
- Place of Presentation
  WI, USA
- Year and Date
  2014-10-17 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 機能カセットノックインマウスのためのCRISPR/Casを用いたin vivoゲノム編集
- Author(s)
  相田知海, Keiho Chiyo, 佐久間哲史, 宇佐美貴子, 石久保春美, 今橋里沙, 田中謙二, 山本卓, 田中光一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集技術による簡便迅速かつ高効率な次世代染色体工学の開発
- Author(s)
  野村淳, 佐久間哲史, 神田暁史, 岸本恵子, 前田知花, 外丸祐介, 山本卓, 内匠透
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集の原理と基礎知識
- Author(s)
  佐久間哲史
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11 – 2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集の基礎と動物における利用の現状
- Author(s)
  佐久間哲史
- Organizer
  平成26年度日本実験動物技術者協会関西支部秋季広島大会
- Place of Presentation
  広島
- Year and Date
  2014-11-29 – 2014-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] TALEN-mediated genome editing is very useful in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration
- Author(s)
  Toshinori Hayashi, Kousuke Sakamoto, Tetsushi Sakuma, Ayumi Myouga, Naoki Yokotani, Takeshi Inoue, Eri Kawaguchi, Kiyokazu Agata, Takashi Yamamoto, Takashi Takeuchi
- Organizer
  第47回日本発生生物学会
- Place of Presentation
  愛知
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Transcription activator-like effector nucleases (TALENs)システムを用いて作製したphosphatase and tensin homolog (PTEN)ノックアウトメダカ
- Author(s)
  松崎ゆり子, 佐久間哲史, 山本卓, 佐谷秀行
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Platinum TALENおよびCRISPR/Cas9を用いたゲノム編集
- Author(s)
  佐久間哲史
- Organizer
  第39回日本比較内分泌学会大会
- Place of Presentation
  岡崎
- Year and Date
  2014-11-07 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ネフロン前駆細胞特異的レポーター遺伝子を持つiPS細胞の樹立
- Author(s)
  賀来祐介, 太口敦博, 佐久間哲史, 山本卓, 西中村隆一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Duchenne型筋ジストロフィーiPS細胞の遺伝子修復とゲノムワイド変異解析
- Author(s)
  李紅梅, 藤本直子, 笹川典子, 白井紗矢, 大亀登紀子, 佐久間哲史, 田中道廣, 天野直己, 渡辺亮, 櫻井英俊, 山本卓, 山中伸弥, 堀田秋津
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] 糸状菌型Platinum TALENの作製とイネいもち病菌(糸状菌)における高効率遺伝子改変
- Author(s)
  荒添貴之, 小川哲央, 大里修一, 佐久間哲史, 山本卓, 有江力, 桑田茂
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] ゲノム編集の基礎と最新動向
- Author(s)
  佐久間哲史
- Organizer
  第4 回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] Genome editing using Platinum TALENs
- Author(s)
  Tetsushi Sakuma, Ken-ichi Suzuki, Takashi Yamamoto
- Organizer
  FASEB Science Research Conference: Genome Engineering - Cutting-Edge Research and Applications
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25890014
[Presentation] マルチgRNAシステムを用いたCRISPR/Cas9によるゲノム編集
- Author(s)
  佐久間哲史, 中出翔太, 西川綾美, 茶山一彰, 鈴木賢一, 山本卓
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25890014

1. YAMAMOTO TAKASHI (90244102)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. Nishimichi Norihisa (00583486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Nakagata Naomi (30159058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. Shukunami Chisa (60303905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Yuki Yoshimoto (40735304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 仙谷和弘 (30508164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横崎恭之 (80210607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 外丸祐介 (90309352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 細羽康介 (20781264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中川佳子 (30732739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
11. 三浦重徳 (70511244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石田紗恵子 (50777927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 栗田朋和 (40788915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 深澤拓也 (20379845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 近藤英作 (30252951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山辻知樹 (40379730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 瀧川奈義夫 (60325107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ABE Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. TAKADA Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. AWAZU Akinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. OHSATO Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. SUENAGA Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. NAKAZAWA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. SUZUKI Kenichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. KITABATAKE Yasuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. YAGI Hirokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 栗山正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 堀居拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 森田純代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 坂本敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 岡田徹也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 武田俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 曽根岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 落合博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 岡本仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 松浦伸也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 宮本達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
38. 笹倉靖徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
39. 桧山英三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 高山和雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 木下勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 下出紗弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 矢中規之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 堀江健生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 中出翔太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 江良択実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 秋庸裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 野地澄晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 田中光一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 山崎創

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 西中瑶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 阿形清和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 安藤清宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 東島恵美子(宍戸恵美子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 楯真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 坂本尚昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
57. 荒添貴之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 高橋武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 川上潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 池田啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. KNUT Woltjen

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
63. 吉開康信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakuma Tetsushi 佐久間 哲史

SAKUMA TETSUSHI 佐久間 哲史

Research Projects

Research Products

Co-Researchers

Development and application of multi-functional and orthogonal genome editing platform named CRISPR-bacflipPrincipal Investigator

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微細藻類における導入遺伝子サイズや導入回数の制限を解除する新規ノックイン法の開発

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Elucidation of molecular pathogenesis and carcinogenesis in pulmonary large cell neuroendocrine carcinoma using patient derived organoids

Principal Investigator

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マウスin vivo エピゲノム編集による焦点性てんかん発症機序の解明

Principal Investigator

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Review Section

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Development of muliplex, large-scale, and high-resolution genome editing technology using multi-class CRISPR systemPrincipal Investigator

Principal Investigator

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Research Institution

Development of a novel epigenome editing technology using the expanded TREE system and its application in cancer studyPrincipal Investigator

Principal Investigator

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Development of genome editing platform technology for various disease models

Principal Investigator

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Development of disease-modeling technology using hierarchical genome/epigenome editingPrincipal Investigator

Principal Investigator

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Establishment of a new mouse model of cledocranial dysplasia by TALEN mediated genome editing

Principal Investigator

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Role of polymeric OPN on fibrosis

Principal Investigator

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Application of lipofection-mediated genome editing in mouse zygotes created by IVF via ultra-superovulation

Principal Investigator

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Development of CRISPR/Cas system enabling advanced genome editing on chromosome levelPrincipal Investigator

Principal Investigator

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TALEヌクレアーゼを用いた遺伝子ノックイン/ノックアウト技術の確立と応用Principal Investigator

Principal Investigator

Project Period (FY)

Sakuma Tetsushi 佐久間哲史

SAKUMA TETSUSHI 佐久間哲史

[Book] 完全版　ゲノム編集実験スタンダード2019

[Book] 完全版　ゲノム編集実験スタンダード2019