Meng Hong Rui 孟紅蕊

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MENG Hongrui 孟紅蕊

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Researcher Number	90736498
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 順天堂大学, 医学部, 非常勤助教 2020: 順天堂大学, 医学(系)研究科(研究院), 非常勤助教 2019: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2017 – 2018: 順天堂大学, 医学(系)研究科(研究院), 博士研究員 2017: 順天堂大学, 医学研究科, 研究員 2016: 順天堂大学, 医学(系)研究科(研究院), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator CHCHD2 / ミトコンドリア / パーキンソン病 / α-Synuclein / alpha-Synuclein / リソソーム / Ca2+ / カルシウム / TDP-43 / ショウジョウバエ … More / 筋萎縮性側索硬化症 / α-synuclein / CHCHD２ / 神経変性 … More Except Principal Investigator 神経変性疾患 / キナーゼ / 神経変性 / シグナル伝達 / 遺伝学 / 酸化ストレス / ユビキチン / パーキンソン病 / ショウジョウバエ / ドパミン神経 / iPS / CHCHD2 / Parkin / PINK1 / リン酸化 / iPS細胞 / ドーパミン神経 / ミトコンドリア Less

Characterization of disease-specific variants of the mitochondrial protein CHCHD2Principal Investigator
- Principal Investigator
  
  Meng Hongrui
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Analysis of the molecular mechanism by which mitochondrial dysfunction leads to alpha-Synaclein aggregationPrincipal Investigator
- Principal Investigator
  
  Meng Hongrui
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Characterization of Parkinson's disease-associated protein CHCHD2 and its molecular signaling networkPrincipal Investigator
- Principal Investigator
  
  Meng Hongrui
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Methods Mol Biol.2017
- Author(s)
  Imai Y, Inoshita T, Shiba-Fukushima K, Meng H, Hattori N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease.2019
- Author(s)
  Imai Y, Inoshita T, Meng H, Shiba-Fukushima K, Hara KY, Sawamura N, Hattori N.
- Journal Title
  
  Commun Biol.
  
  Volume: 2 Issue: 1 Pages: 424-424
- DOI
  10.1038/s42003-019-0674-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15465
[Journal Article] Mutations in CHCHD2 cause α-synuclein aggregation2019
- Author(s)
  Ikeda A., Nishioka K., Meng H., Takanashi M., Hasegawa I., Inoshita T., Shiba-Fukushima K., Li Y., Yoshino H., Mori A., Okuzumi A., Yamaguchi A., Nonaka R., Izawa N., Ishikawa K.I., Saiki H., Morita M., Hasegawa M., Hasegawa K., Elahi M., et al.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 28 Issue: 23 Pages: 3895-3911
- DOI
  10.1093/hmg/ddz241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-18K15465
[Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019
- Author(s)
  Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116(41) Issue: 41 Pages: 20689-20699
- DOI
  10.1073/pnas.1902958116
- NAID
  120007132272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K06978, KAKENHI-PROJECT-19K07042, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K16928, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-PUBLICLY-18H05025, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-19H03372, KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-16H02613
[Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia2019
- Author(s)
  Imai Yuzuru、Meng Hongrui、Shiba-Fukushima Kahori、Hattori Nobutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 4 Pages: 908-908
- DOI
  10.3390/ijms20040908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-16K19525
[Journal Article] Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila2017
- Author(s)
  Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Hongrui Meng, Nobutaka Hattori, Yuzuru Imai
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1007/7651_2017_9
- ISBN
  9781493977499, 9781493977505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-16K09679
[Journal Article] Measurements of the mitochondrial respiration and glycolytic activity in Drosophila embryonic cells2017
- Author(s)
  Meng Hongrui、Yamashita Chikara、Hattori Nobutaka、Imai Yuzuru
- Journal Title
  
  Protocol Exchange
  
  Volume: －
- DOI
  10.1038/protex.2017.069
- Open Access
- Data Source
  KAKENHI-PROJECT-16K19525
[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 15500-15500
- DOI
  10.1038/ncomms15500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N, JaCALS
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07361
[Presentation] Analyses of CHCHD2 pathophysiology by human brain, iPSC and Drosophila model2020
- Author(s)
  Aya Ikeda, Hongrui Meng2 , Kenya Nishioka, Masashi Takanashi, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Akio Mori, Risa Nonaka, Nana Izawa, Keiichi Ishikawa, Hidemoto Saiki, Masayo Morita, Manabu Funayama, Masato Hasegawa, Hideyuki Okano, Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07361
[Presentation] CHCHD2変異がα-シヌクレインの凝集化を促進する2019
- Author(s)
  孟紅蕊、井下強、柴-福島佳保里、池田彩、西岡健弥、今居譲、服部信孝
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15465
[Presentation] 生体膜恒常性の変調によるα-Synuclein凝集メカニズム2019
- Author(s)
  今居譲、森暁生、井下強、柴-福島佳保里、孟紅蕊、服部信孝
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15465
[Presentation] Analyses of CHCHD2 pathophysiology by human brain, iPSC and Drosophila model2019
- Author(s)
  Ikeda A, Meng H, Nishioka K, Takanashi M, Li Y, Yoshino H, Inoshita T, Shiba-Fukushima K, Okuzumi A, Mori A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa KI, Saiki H, Morita M, Funayama M, Hasegawa M, Okano H, Akamatsu W, Imai Y, Hattori N
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15465
[Presentation] Mutations of CHCHD2 accelerate α-synuclein aggregation, conferring a prion-like seeding property to α-synuclein2019
- Author(s)
  Meng H, Ikeda A, Nishioka K, Takanashi M, Inoshita T, Shiba-Fukushima K, Okuzumi A, Funayama M, Imai Y, Hattor N
- Organizer
  第42回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15465
[Presentation] Mutations of CHCHD2 exacerbate α-synuclein accumulation in Drosophila2018
- Author(s)
  孟　紅蕊
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K19525
[Presentation] Mutations of CHCHD2 exacerbate α-synuclein accumulation in Drosophila2018
- Author(s)
  孟　紅蕊
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K15465
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
- Author(s)
  Meng Hongrui、Yamashita Chikara、Shiba-Fukushima Kahori、Inoshita Tsuyoshi、Imai Yuzuru、Hattori Nobutaka
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K19525
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会　シンポジウム
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] The Loss of Parkinson's Disease-Associated Protein CHCHD2 Affects Mitochondrial Cristae Structure and Destabilizes Cytochrome c2016
- Author(s)
  Hongrui Meng, Chikara Yamashita, Kahori Shiba, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Yuzuru Imai, Nobutaka Hattori
- Organizer
  第39 回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K19525
[Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
- Author(s)
  山下力、孟　紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御2016
- Author(s)
  井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、服部　信孝、今居　譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] CHCHD２, a Parkinson’s-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
- Author(s)
  Hongrui Meng, Chikara Yamashita, Kahori Shiba, Tsuyoshi Inoshita, Yuzuru Imai, Nobutaka Hattori
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16K19525
[Presentation] Mutations of mitochondrial protein CHCHD2 lead to parkinson’s disease-like phenotypes in Drosophila2016
- Author(s)
  Hongrui Meng, Chikara Yamashita, Kahori Shiba, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Yuzuru Imai, Nobutaka Hattori
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-16K19525
[Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes2015
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Cell Symposia
- Place of Presentation
  シカゴ
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293070

1. INOSHITA Tsuyoshi (20601206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. SHIBA Kahori (30468582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Imai Yuzuru (30321730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. ARANO Taku (80750091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HATANO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Meng Hong Rui 孟 紅蕊

MENG Hongrui 孟 紅蕊

Research Projects

Research Products

Co-Researchers

Characterization of disease-specific variants of the mitochondrial protein CHCHD2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the molecular mechanism by which mitochondrial dysfunction leads to alpha-Synaclein aggregationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of Parkinson's disease-associated protein CHCHD2 and its molecular signaling networkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods Mol Biol.2017

Author(s)

Publisher

Data Source

[Journal Article] Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations in CHCHD2 cause α-synuclein aggregation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila2017

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Measurements of the mitochondrial respiration and glycolytic activity in Drosophila embryonic cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022

Author(s)

Organizer

Data Source

[Presentation] Analyses of CHCHD2 pathophysiology by human brain, iPSC and Drosophila model2020

Author(s)

Organizer

Data Source

[Presentation] CHCHD2変異がα-シヌクレインの凝集化を促進する2019

Author(s)

Meng Hong Rui 孟紅蕊

MENG Hongrui 孟紅蕊