SATO Mitsunobu 佐藤光信

Researcher Number	00028763
Other IDs
Affiliation (based on the past Project Information) *help	2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 1987 – 2003: 徳島大学, 歯学部, 教授 1986: 徳島大, 歯学部, 教授
Review Section/Research Field	Principal Investigator Surgical dentistry / 外科・放射線系歯学 / Surgical dentistry / 病態科学系歯学(含放射線系歯学) Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator OK-432 / ヒト唾液腺癌細胞 / 口腔癌 / アポトーシス / 分化誘導 / DNA hypomethylation / 唾液腺癌細胞 / 放射線 / ベスナリノン / Oral cancer … More / 抗腫瘍効果 / Toll-like receptor 4 / リポタイコ酸関連分子 / TSC-22 / LAK cells / 末梢リンパ球亜群 / LAK細胞 / NF-κB / UFT / MD-2 / 放射線治療 / NO / 口腔扁平上皮癌 / 5-フルオロウラシル / リポタイコ酸 / 細胞分化 / FdUMP / Apoptosis / Human salivary cancer cells / Hexamethylene bisacetamide / dibutyryl cAMP / 癌免疫療法 / NF-kB / p27^<Kip1> / p21^<Waf1> / IFN-γ / 転写活性化能 / 分化誘導療法 / 唾液腺癌 / p21^<WAF1> / 抗腫瘍活性 / 骨芽細胞 / 分化因子 / 唾液腺腺房細胞 / 造腫瘍性ヒト唾液腺介在部導管上皮細胞 / Radiotherapy / Subsets of peripheral blood lymphocytes / Local immunotherapy / Interleukin 2 / インターロイキン2 / 局所免疫療法 / インタ-ロイキン2 / Therapy of Oral cancer / Phenotype of cancer cells / Subsets of peripheral blood lymphocyte / NK cells / Killer lymphocyte / Immune response / Killer リンパ球 / 単クローン抗体 / リンパ球亜群 / ADCC / Killerリンパ球 / 口腔癌治療 / 癌細胞表現形質 / 抹消リンパ球亜群 / NK細胞 / killerリンパ球 / 免疫応答 / Lipoteichoic acid-related molecule / Radiation / DC局所療法 / 樹状細胞(DC) / テガフール / Toll様受容体4 / リポタイコ酸関連分子OK-PSA / 抗腫瘍免疫療法剤OK-432 / Toll-like receptor4 / anti-tumor effect / Th1-type cytokine / lipoteichoic acid-related molecule / radiotherapy / iNOS gene / oral cancer / NK / TIL / iNOS / 口腔小唾液腺癌 / iNos遺伝子 / Th1-タイプサイトカイン / iNOS遺伝子 / p27^<Klp1> / oral squamous cell carcinoma / salivary gland cancer / p21^<waf1> / apoptosis / cellular differentiation / vesnarinone / TGF-β / p27^<kip1> / p21^<WAF> / 5-Fluorouracil / p27^<Kipl> / 口腔扁平皮癌 / killer cells / liposome / cytokine / head and neck cancer / 5-fluorouracil / radiation / lipoteichoic acid / キラー活性 / 頭頚部癌 / キラー細胞 / リポソーム / サイトカイン / 頭頸部癌 / Plectin / Proteosome / Cytokeratin / Cellular differentiation / Drug receptor / プレクチン / プロテオソーム / サイトケラチン / 薬物受容体 / Anti-tumor agents / Salivary adenoid squamous carcinoma-forming cells / Screening system / Cellular differentiation-inducing agents / 分化誘導剤 / 造腫瘍性ヒト腺房細胞癌細胞 / 口腔小唾液腺由来腺様扁平上皮癌細胞 / 抗癌剤 / 唾液腺由来腺様扁平上皮癌細胞 / スクリーニングシステム / 細胞分化誘導剤 / Protein kinase A / Protein kinase C / Differentiation therapy / 8-chloroadenosine 3' : 5'-cyclic monophosphate / Human salivary gland cancer cells / Hー7 / プロテイン・キナ-ゼC / 8ーchloro odenosine 3':5'ーcyclic monophosphate / 高転移性唾液腺癌細胞 / 5-fluoro-2'-deoxyuridine / エトポシド / グリア線維酸性蛋白 / ニューロフイラメント / 不死化正常ヒト唾液腺細胞 / 高転移性ヒト唾液腺癌細胞 / 8-chloroadenosine 3':5'-cyclic monophosphate / プロテイン・キナーゼA / プロテイン・キナーゼC / 8-chloroadenosine3':5'-cyclic monophosphate / Hesamethylene bisacetamide / 放射線療法 / 5-FU / SOCS-1 / 抗腫瘍性サイトカイン / Toll-like receptor 9 / 細菌DNA / pAkt / 抗癌効果 / タキソテール / ノックアウトマウス / INF-α / 細胞受容体 / IL-2 / LAK / 放射線感受性 / 抗癌剤感受性 / TSC-22遺伝子 / 分化誘導抑制効果 / 口腔扁平上皮癌細胞 / nm23遺伝子 / EBNA / EBVレセプター抗原(CR-2) / EBVレセプター / C3d / EBV / ヒト唾液腺癌細胞HSG / TGF-β1 / 破骨細胞 / オステオネクチン / オスチオポンチン / I型コラーゲン / アルカリフォスファターゼ / oxa型ビタミンD誘導体 / 分化因子遺伝子 / 唾液腺筋上皮細胞 / 唾液腺上皮細胞 … More Except Principal Investigator ヒト唾液腺癌細胞 / DNAメチル化 / Cbfa1 / BMP-2 / 癌増殖 / オートクライン / パラクライン / サイトカイン / ヒト癌細胞 Less

口腔癌におけるSOCS-1遺伝子制御因子の探索:OK-432,5-FU,放射線Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
OK-432の細菌DNAにおける抗腫瘍活性の探索Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
口腔癌細胞における抗癌剤タキソテールと分化誘導剤ベスナリノン併用の抗癌効果の検索Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞のDNA脱メチル化による分化誘導―骨芽細胞への変換
- Principal Investigator
  
  内田大亮
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Toll-like receptor 4 signaling : Enhancement of therapeutic effect of anti-cancer drugs and radiation in oral CancerPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
OK-432由来リポタイコ酸関連分子の細胞受容体の探索Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
LAK,IL-2,放射線との併用によるヒト唾液腺癌細胞の骨芽細胞への分化誘導Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of the therapy for oral cancer by transduction of iNOS gene in combination with radiotherapyPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
唾液腺癌のベスナリノンによる分化誘導療法に関する基礎的研究Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
口腔扁平上皮癌細胞におけるnm23遺伝子の分化誘導抑制効果とその制御Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinonePrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞におけるEpstein-Barrウイルス持続感染Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancerPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
ヒト唾液腺の癌細胞におけるベスナリノンの抗腫瘍活性Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞のoxa型ビタミンD誘導体による骨芽細胞への分化誘導に関する研究Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Detection of Novel Drug Receptor and Mechanism of Induction of Differentiation and Apoptosis in Human Salivary Cancer CellsPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Development of screening system for searching cellular differentiation-inducing agents by utlizing human salivary cancer cellsPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  The University of Tokushima
ヒトがん細胞のパラクライン因子とがん増殖の免疫生物学的研究
- Principal Investigator
  
  小倉剛
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
Study of Differentiation Therapy for Salivary Gland CancerPrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  THE UNIVERSITY OF TOKUSHIMA
ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性Principal Investigator
- Principal Investigator
  
  佐藤光信
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
Local Immunotherapy of Oral Cancer with LAK Cells and Interleukin 2Principal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima
Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic SignificancePrincipal Investigator
- Principal Investigator
  
  SATO Mitsunobu
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  The University of Tokushima

All 2006 2005 2004 2003 2002

All Journal Article Book

[Book] Streptococcal preparation, OK-432-based immunotherapy for head and neck cancer : Possible stimulation of dendritic cells via Toll-Like Receptor 42005
- Author(s)
  Masato Okamoto
- Total Pages
  255
- Publisher
  Global Research Network
- Data Source
  KAKENHI-PROJECT-14207090
[Book] Current progress of human cancer gene therapy-Head and neck cancer-(Oral Surgery Hand Manual)(Seto K, Noma H, Katsuki T, Ueda M (ed.))2003
- Author(s)
  Mitsunobu Sato
- Publisher
  Quintessence Press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Book] Effective molecule of a streptococcal preparation OK-432 and its molecular targets : Significance for cancer immunotherapy.2003
- Author(s)
  Masato Okamoto
- Total Pages
  370
- Publisher
  Transworld Research Network
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Book] Effective molecule of a streptococcal preparation OK-432 and its molecular targets : Significance for cancer immunotherapy. (Recent Research Development in Infection & Immunity Vol 1)(S.G.Pandalai (ed.))2003
- Author(s)
  Masato Okamoto
- Publisher
  Transworld Research Network, Kerala, India
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Mechanism of anti-cancer host response induced by OK-432,a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.2006
- Author(s)
  Masato Okamoto
- Journal Title
  
  J Immunother 29(1)
  
  Pages: 78-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.2006
- Author(s)
  Masato Okamoto
- Journal Title
  
  J Immunother 29・1
  
  Pages: 78-86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling2006
- Author(s)
  Masato Okamoto
- Journal Title
  
  J Immunother 29・1
  
  Pages: 78-86
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effet of dendritic cell-based immunotherapy in conbination with an active component of OK-432, a streptococcal preparation2004
- Author(s)
  Masato Okamoto
- Journal Title
  
  Cancer Res 64・15
  
  Pages: 5461-5470
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation2004
- Author(s)
  Masato Okamoto
- Journal Title
  
  Cancer Res 64・15
  
  Pages: 5461-5470
- Data Source
  KAKENHI-PROJECT-16659556
[Journal Article] Expression of Toll-like receptor 4 on dendritic cells is significant for anti cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432,a streptococcal preparation.2004
- Author(s)
  Masato Okamoto
- Journal Title
  
  Cancer Res 64(15)
  
  Pages: 5461-5470
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation.2004
- Author(s)
  Masato Okamoto
- Journal Title
  
  Cancer Res 64・15
  
  Pages: 5461-5470
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Involvement of Toll-like receptor 4 signaling in interferon-g production and anti-tumor effect by a streptococcal agent OK-432.2003
- Author(s)
  Masato Okamoto
- Journal Title
  
  J Natl Cancer Inst 95(4)
  
  Pages: 316-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Involvement of Toll-like receptor 4 signaling in interferon-g production and ante-tumor effect by a streptococcal agent OK-432.2003
- Author(s)
  Masato Okamoto
- Journal Title
  
  J Natl Cancer Inst 95・4
  
  Pages: 316-326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma : Role of natural killer cells.2002
- Author(s)
  Masato Okamoto
- Journal Title
  
  Anti-Cancer Res 22・6(A)
  
  Pages: 3229-3240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207090
[Journal Article] Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432,a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma : Role of natural killer cells.2002
- Author(s)
  Masato Okamoto
- Journal Title
  
  Anti-Cancer Res 22(6A)
  
  Pages: 3229-3240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207090

1. YOSHIDA Hideo (30116131)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. YURA Yoshiaki (00136277)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. AZUMA Masayuki (20144983)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. OKAMOTO Masato (10243718)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
5. YANAGAWA Tetsuo (40136263)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. KAWAMATA Hitoshi (70224847)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. 伊賀弘起 (40175188)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. HARADA Koji (60253217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 洪英満

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KAJI Ryoji (30204390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKEGAWA Yoshihiro (40035754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 上野明道 (80136267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小倉剛 (00028490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山口建 (90124429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 東野一彌 (30028419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 新津洋司郎 (10045502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 杉山治夫 (70162906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 板東高志 (80208727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 内田大亮 (20335798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 林良夫 (00127854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SATO Mitsunobu 佐藤 光信

Research Projects

Research Products

Co-Researchers

口腔癌におけるSOCS-1遺伝子制御因子の探索:OK-432,5-FU,放射線Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

OK-432の細菌DNAにおける抗腫瘍活性の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔癌細胞における抗癌剤タキソテールと分化誘導剤ベスナリノン併用の抗癌効果の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト唾液腺癌細胞のDNA脱メチル化による分化誘導―骨芽細胞への変換

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Toll-like receptor 4 signaling : Enhancement of therapeutic effect of anti-cancer drugs and radiation in oral CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

OK-432由来リポタイコ酸関連分子の細胞受容体の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LAK,IL-2,放射線との併用によるヒト唾液腺癌細胞の骨芽細胞への分化誘導Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the therapy for oral cancer by transduction of iNOS gene in combination with radiotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

唾液腺癌のベスナリノンによる分化誘導療法に関する基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

口腔扁平上皮癌細胞におけるnm23遺伝子の分化誘導抑制効果とその制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on differentiation and apoptosis-inducing therapy for head and neck cancer by vesnarinonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト唾液腺癌細胞におけるEpstein-Barrウイルス持続感染Principal Investigator

Principal Investigator

Project Period (FY)

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Lipoteichoic acid : Augmentation of the therapeutic effect of radiation and 5-fluorouracil in head and neck cancerPrincipal Investigator

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SATO Mitsunobu 佐藤光信