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Tanaka Toshio  田中 利男

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TANAKA Toshio  田中 利男

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Researcher Number 00135443
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 特定教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 三重大学, 医学系研究科, 特定教授
2021 – 2023: 三重大学, 医学系研究科, 産学官連携講座大学教員
2022: 三重大学, 医学系研究科, 産学官連携講座大学教員(特定教授)
2018: 三重大学, 医学系研究科, 産学官連携講座大学教員
2016 – 2017: 三重大学, 医学系研究科, 教授 … More
2011 – 2016: 三重大学, 医学(系)研究科(研究院), 教授
2014: 三重大学, 大学院医学系研究科, 教授
2012: 三重大学, 大学院・医学系研究科, 教授
1988 – 2004: Mie University School of Medicine, Professor, 医学部, 教授
1986 – 1987: 三重大学, 医学部, 講師
1986: 三重大, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
応用薬理学・医療系薬学 / General pharmacology / Biological Sciences / General pharmacology / Basic Section 48030:Pharmacology-related / Applied pharmacology
Except Principal Investigator
Basic Section 56030:Urology-related / 物質生物化学 / General pharmacology / Pediatrics … More / General pharmacology / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / 分子遺伝学・分子生理学 / Hygiene and public health / Risk sciences of radiation/Chemicals / Biological pharmacy / Digestive surgery Less
Keywords
Principal Investigator
S100C / カルシウム結合蛋白質 / 遺伝子発現 / 脳血管攣縮 / カルシウム / S100L / トランスクリプトーム / カルモデュリン / 低酸素 / 心筋 … More / S100蛋白質 / カルポニン / ゼブラフィッシュ / HSP72 / actin / gene expression / 分子薬理学 / caltractin / in situ hybridization / mRNA differential display / Tumor Cell / Differential Gene Expression / Calcium-binding Proteins / 癌細胞 / 遺伝子発現変化 / PAF / Calmodulin / S100 protein / プロテオーム / cerebral vasospasm / 脳血管障害 / Heme Oxygenase-1 / トランスクリプトーム解析 / EFハンド / カルシウム感受性 / プロテインキナーゼ / ラット / cDNAクローニング / S100蛋白質ファミリー / 分子生物学 / 分化制御 / アクチン / カルシウムイオン / 平滑筋 / ⑤ゼブラフィッシュ / ④がん分子標的薬 / ③心毒性機構解析 / ②心毒性防御遺伝子 / ①ハイスループットスクリーニングシステム / がん分子標的薬 / 心毒性機構解析 / ハイスループットスクリーニングシステム / cardiotoxic genes / 心毒性防御遺伝子 / ハイスループットスクリーニング / nilotinib / stanniocalcin1 / sorafenib / oncocardiology / zebrafish / がん幹細胞選択性 / 蛍光試薬 / 免疫不全マウス / ヒトがん幹細胞治療薬 / 悪性腫瘍治療抵抗性 / ZM-B708 / ヒトがん幹細胞阻害薬 / Myosin Light Chain Kinase / Calpain / Calcium-dependent Protease / Protein Kinase C / Molecular Pharmacology / Intracellular Calcium-Receptine Protein / カルモデュリン依存性酵素 / パルブアルブミン / トロポニンC / カルシウムチャンネルブロッカー / カルモデュリン阻害剤 / ミオシン軽鎖リン酸化酵素 / カルパイン / カルシウム依存性プロテアーゼ / プロテインキナーゼC / 細胞内カルシウム受容蛋白質 / proteome database / pulmonary hypertension / stress protein / proteome / vascular remodeling / くも膜下出血 / クモ膜下出血 / タウリン / 低酵素 / プロテオームデータベース / 肺高血圧症 / ストレス蛋白質 / 血管リモデリング / splicing / phosphodiesterase / Basedow's disease / thyroid disease / Pharmacogenomics / クローニング / スプライシング / PDE / バセドウ病 / 甲状腺疾患 / 薬理ゲノミクス / hypoxia / Mg2+-ATPase / calcium sensitization / 血管収縮 / Mg-ATPase活性 / Mg-ATPase / Actin Binding Proteins / calcium / Gene Expression / Disease / S100 Protein Family / 種々の病態 / アクチン結合タンパク質 / 病態 / S100ファミリー / Genomic Gene / Hypoxia / Ischemic Heart Disease / genomic gene / 虚血性心疾患 / breast carcinoma / human clinical pathology / gene therapy / マルチメディアデータベース / キャピラリー電気泳動 / 薬物治療遺伝子 / 病態遺伝子 / 螢光ディファレンシャル・ディスプレイ法 / 薬物治療学 / two-hybrid system / 乳癌 / ヒト疾患病態 / 遺伝子治療 / Eosinophilic Chemotactic Factor / Heart Disease / Proplanolol / 好酸球走化性因子 / 心疾患 / プロプラノロール / Signal transduction / Ca^<2+>-binding protein / Chemotaxis / Eosinophil / Leucocyte / 白血球活性化因子 / 細胞内情報伝達 / 好酸球 / 走化性 / 白血球 / Beart / Kidney / Cytoskeleton / Inhibitor / Calcium binding protein / Calcium ion / S100蛋白質ファミリ- / アフィニティ-クロマトグラフィ- / アフィニティークロマドグラフィー / カルシウム情報伝達 / 心臓 / 腎臓 / 細胞骨格 / 阻害薬 / 免疫寛容関連遺伝子 / 異種細胞免疫寛容機構 / 免疫機構 / ヒト前立腺癌細胞 / ヒト慢性骨髄性白血病細胞 / 悪性腫瘍免疫寛容 / システムズ薬理学 / RNA-seq / immunological tolerance / xenotransplantation / cance / Zebrafish / 疾患モデル / 治療遺伝子 / オミックス / 肥満モデル / 創薬・ゲノム薬理学 / 治療薬ターゲット分子 / 病態応答発現蛋白質クラスター / 病態応答遺伝子クラスター / 遅発性脳血管攣縮 / 薬理プロテオームデータベース / 薬理プロテオミクス / ヘムオキシゲナーゼ / マイクロアレイ / ゲノム創薬 / 遺伝子クラスター / DNAマイクロアレイ / heat shock protein 27 / heat shock protein 72 / antisense oligodeoxynucleotide / rat / basilar artery / hemin / cGMP / CO / 脳虚血 / DNAチップ / ゲノム創薬科学 / 脳底動脈 / 創薬ターゲット / 治療関連遺伝子 / 疾患関連遺伝子 / 薬理ゲノム科学 / ハイポキシアレスポンスエレメント / カルシウム結合蛋白 / 悪性腫瘍 / in silico cDNAクローニング / ESTデータベース / ディファレンシャル・ディスプレイ法 / マイクロアレイ法 / プロテインキナーゼ阻害薬 / チロシンキナーゼ / セリン・スレオニンキナーゼ / カルシウムセンシタイザー / 収縮機構 / 血管平滑筋 / 活性ペプチド / リン酸化部位 / ラフト / 転写因子 / トロポミオシン / 蛋白質リン酸化反応 / プロテインキナ-ゼC / cDNAクロ-ニング / Cキナ-ゼ / cAMP依存性蛋白質リン酸化酵素 / cAMP / メラノーマ / がん細胞 / Sー100 … More
Except Principal Investigator
ゼブラフィッシュ / ML-9 / ミオシン軽鎖キナーゼ / Cキナーゼ / シスプラチン / 膀胱癌 / Myosin light chain kinase / cDNAマイクロアレイ / 肺高血圧 / 低酸素 / 平滑筋 / 炎症 / DNAマイクロアレイ / 耐性機序 / 患者由来異種移植モデル / 薬剤効果判定 / 膀胱がん / 薬物療法 / 異種移植モデル / 心血管・血液 / オミックス解析 / 公共データベース / ユビキチン・プロテアソーム系 / 酸化ストレス / ゲノム編集 / データベース / オミクス解析 / トランスクリプトーム / 肥大型心筋症 / 血管生物学 / エンドセリン / 動物モデル / 血管平滑筋 / 病態 / 治療 / 肺動脈性肺高血圧 / Protein kinase C / Affinity chromatography / Thyroxine / サイロキシン / Aキナーゼ / アフィニティークロマトグラフ / プロテインキナーゼ阻害剤 / protein phosphorylation / Platet / ミオシン軽鎖リン酸化酵素 / 蛋白質リン酸化反応 / 血小板 / Myosin Light Chain Kinase Inhibitor / Aggregation and Secretion Response of Platelets / Myosin Light Chain Kinase Vascular Smooth Muscle Contraction / Myosin Light Chain Phosphorylation / Intracellular Calcium Requlation / 血小板放出反応 / 平滑筋収縮反応 / カルシウム依存性リン酸化反応 / 分子薬理学 / MLー9 / ミオシン軽鎖キナーゼ阻害剤 / 放出反応 / 血小板凝集 / 血管平滑筋収縮 / ミオシン軽鎖リン酸化反応 / 細胞内カルシウム調節機構 / DNA Microarray / Hypoxia / Pulmonary Hypertension / 肺高血圧症 / DNA microarray / pulmonary hypertension / hypoxia / 低酵素 / 肺高気圧 / Centrifuge Microscope / NMR / Motility Assay / Regulation / Calcium / Myosin / Actin / Motor protein / ATP / ダイニン / チュブリン / 原形質流動 / シャジク藻 / カルデスモン / カルポニン / アクトミオシン / アイチン / モーティリティー・アッセイ / 遠心顕微鏡 / 核磁気共鳴 / モ-ティリティー・アッセイ / 制御機能 / カルシウム / ミオシン / アクチン / モーター蛋白質 / 免疫組織化学 / モノクローナル抗体 / CDNAクローン / 発癌プロモーター / 細胞増殖 / チロシンキナーゼ / 心血管毒性 / 安全性 / 環境衛生 / 衛生学 / 環境毒性学 / リスクアセスメント / ナノ素材 / 動脈硬化 / カーボンナノチューブ / ナノ粒子 / 環境ストレス / ゲノム / 薬理 / バイオインフォマティクス / 脂質異常症 / 肥満 / 蛍光生体イメージング / 放射線影響評価 / スクリーニング / 治療薬 / 行動解析 / 発達神経毒性 / 放射線 / マイクロアレイ / 遺伝子 / 遺伝子発現プロファイル / 機能ゲノム科学 / 創薬 / 癌遺伝子 / 癌抑制遺伝子 / 螢光ディファレンシャル・ディスプレイ / 遺伝子発現 / 胆管癌 Less
  • Research Projects

    (48 results)
  • Research Products

    (98 results)
  • Co-Researchers

    (52 People)
  •  Basic research for clinical application of patient-derived xenograft avatar model by zebrafish

    • Principal Investigator
      井上 貴博
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Mie University
  •  Zebrafish-based oncocardiology research on molecular targeted drugs for cancer.Principal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Mie University
  •  Clinical application of patient-derived xenograft zebrafish model of bladder cancer for evaluating drug efficacy and discovering new seeds of treatment

    • Principal Investigator
      INOUE TAKAHIRO
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Mie University
  •  Systems pharmacology for discovering novel genes related to hypertrophic cardiomyopathy

    • Principal Investigator
      Nishimura Yuhei
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  New treatment for pulmonary arterial hypertension targeting on inflammation-dedifferentiation pathway

    • Principal Investigator
      Mitani Yoshihide
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Mie University
  •  in vivo Mechanisms of Novel Selective Fluorescent Leukemia Stem Cell InhibitorPrincipal Investigator

    • Principal Investigator
      Tanaka Toshio
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  Investigation on the effects of environmental stress on the cardiovascular system

    • Principal Investigator
      ICHIHARA Sahoko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene and public health
    • Research Institution
      Mie University
  •  Novel immunological tolerance in zebrafish of human cancer cell xenotransplants and cancer immunotherapy mechanismsPrincipal Investigator

    • Principal Investigator
      TANAKA TOSHIO
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  Development of zebrafish-based assay to detect developmental neurotoxicity of irradiation and to identify protectants against the neurotoxicity

    • Principal Investigator
      NISHIMURA Yuhei
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Mie University
  •  エリオシトリンによるメタボリックシンドローム改善作用の網羅的メカニズム解析

    • Principal Investigator
      島田 康人
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  Identification of novel drug targets with Omics-based mechanismsfor obesity treatmentPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  薬理プロテオミクスの創成と展開Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Mie University
  •  脳血管障害におけるゲノム創薬ターゲットの作用機構解析Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  Transcriptome analysis of hypoxia induced pulmonary hypertension

    • Principal Investigator
      AMANO Homare
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Mie University
  •  脳血管障害におけるゲノム創薬ターゲット探索法の開発Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  トランスクリプトーム解析とファルマインフォマティクスの統合ゲノム薬理学Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  Pharmacoproteomic mechanisms in stress protein expression inductionPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  脳血管障害におけるゲノム創薬科学解析法の開発Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  脳血管攣縮における一酸化炭素(CO)/cGMPシグナリングの治療的役割Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  Pharmacogenomics of thyroid disease in molecular target discoveryPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  Transcriptome analysis of hypoxia-induced pulmonary hypertension

    • Principal Investigator
      AMANO Homare
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Mie University
  •  トランスクリプトーム解析によるゲノム創薬科学Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  創薬、医療を目的とした「機能ゲノム科学」の戦略的手法の樹立

    • Principal Investigator
      内田 和彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tsukuba
  •  シグナル伝達の細胞内局在に関する薬理ゲノム科学的解析Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  プロテインキナーゼ阻害薬による遺伝子発現制御機構Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Mie University
  •  新しいカルシウムシグナリングの分子機構に関する薬理学的研究Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  Genome pharmacology on novel calcium signaling in diseasesPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  Clinical Therapeutic Research of Calcium SensitizationPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  新しいプロティンキナーゼ基質分子のシグナル伝達機構に関する研究Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  胆管癌の遺伝子発現解析と臨床への応用

    • Principal Investigator
      林 正晃
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Mie University
  •  Molecular cell pharmacology on calcium signaling in diseasesPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  Molecular cell pharmacology on Novel calcium signalingPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Mie University
  •  Novel Molecular Pharmacological Strategy in Clinical Therapeutic ResearchPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Mie University
  •  心筋細胞の分化機構に関する分子生物学的研究Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  心筋細胞の分化制御機構に関する分子生物学的研究Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  Molecular Pharmacology of Leucocyte ActivationPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University
  •  新しいS100蛋白質ファミリ-の癌細胞における発現とその調節機構Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  カルポニンを介する平滑筋収縮の調節機構Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  Role of motor proteins in cell motility

    • Principal Investigator
      KOHAMA Kazuhiro
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      Gunma University School of Medicine
  •  Molecular Pharmacology of Calcium Signal TransductionPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University(School of Medicine)
  •  がん細胞における新しいカルシウム結合蛋白質の検索とその機能発現機構の解析Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  CAMP依存性蛋白質リン酸化反応によるカルシウム情報伝達の制御機構Principal Investigator

    • Principal Investigator
      田中 利男
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  Cキナーゼ活性の新規化合物による分子制御機構の細胞生物学的解析

    • Principal Investigator
      日高 弘義
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  Molecular pharmacological approarches of intracellular calcium regulatory mechanisms

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University School of Medicine
  •  Molcular control of platelets function by protein kinases

    • Principal Investigator
      NAKA Michiko
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      Mie University
  •  Development of analytical method of molecular function in protein kinases by using newly synthesized protein kinase inhibitor - affinity chromatography

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      物質生物化学
    • Research Institution
      Nagoya University School of Medicine
      Mie University
  •  発癌機構におけるCキナーゼ及びチロシンキナーゼによる蛋白質リン酸化反応の意義

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  Molecular Pharmacology of Intracellular Calcium-Receptive Protein SignalingPrincipal Investigator

    • Principal Investigator
      TANAKA Toshio
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Mie University

All 2024 2023 2022 2021 2018 2017 2016 2015 2014 2013 2012 2011 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] Cancer Cell Signaling Methods and Protocols2014

    • Author(s)
      Yasuhito Shimada, Yuhei Nishimura, and Toshio Tanaka
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Book] ゲノム研究実験ハンドブック(辻本豪三、田中利男編)2004

    • Author(s)
      田中利男
    • Total Pages
      6
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Book] ゲノム研究実験ハンドブック(辻本 豪三, 田中 利男編)2004

    • Author(s)
      田中利男
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-16659137
  • [Journal Article] ゼブラフィッシュ腫瘍循環器学の新しい展開2024

    • Author(s)
      田中利男
    • Journal Title

      日本臨牀増刊 腫瘍循環器学-新しい学際領域の最新知見-

      Volume: 82巻 4月増刊号

    • Data Source
      KAKENHI-PROJECT-21H02670
  • [Journal Article] Prognostic Effect of Preoperative Psoas Muscle Hounsfield Unit at Radical Cystectomy for Bladder Cancer2021

    • Author(s)
      Sugino Yusuke、Sasaki Takeshi、Kato Manabu、Masui Satoru、Nishikawa Kouhei、Okamoto Takashi、Kajiwara Shinya、Shibahara Takuji、Onishi Takehisa、Tanaka Shiori、Kanda Hideki、Matsuura Hiroshi、Inoue Takahiro
    • Journal Title

      Cancers

      Volume: 13 Issue: 22 Pages: 5629-5629

    • DOI

      10.3390/cancers13225629

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H03066
  • [Journal Article] Tetraploidy in cancer and its possible link to aging.2018

    • Author(s)
      Tanaka K, Goto H, Nishimura Y, Kasahara K, Mizoguchi A, Inagaki M.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 9 Pages: 2632-2640

    • DOI

      10.1111/cas.13717

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08269, KAKENHI-PROJECT-15H02398, KAKENHI-PROJECT-18H02434, KAKENHI-PROJECT-16K08547, KAKENHI-PUBLICLY-18H04896
  • [Journal Article] EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase2018

    • Author(s)
      Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, Tanaka T, Nishimura Y, Mizoguchi A, Goshima N, Inagaki M
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 758-758

    • DOI

      10.1038/s41467-018-03117-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08269, KAKENHI-PLANNED-24113005, KAKENHI-PROJECT-15H02398, KAKENHI-PROJECT-16K08547
  • [Journal Article] New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae2017

    • Author(s)
      Hisashi Matsubara, Yoshitsugu Matsui, Ryohei Miyata, Yuhei Nishimura, Tetsuro Yamamoto, Toshio Tanaka, Mineo Kondo
    • Journal Title

      Documenta Ophthalmologica

      Volume: 135 Issue: 2 Pages: 147-154

    • DOI

      10.1007/s10633-017-9602-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08547, KAKENHI-PROJECT-17K19721
  • [Journal Article] Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch2017

    • Author(s)
      Jing Zhao, Yuhei Nishimura, Akihiko Kimura, Kentaro Ozawa, Toshikazu Kondo, Toshio Tanaka, Masanori Yoshizumi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 16128-16128

    • DOI

      10.1038/s41598-017-15867-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08547, KAKENHI-PROJECT-26293163, KAKENHI-PROJECT-26461277
  • [Journal Article] Titanium dioxide particle type and concentration influence the inflammatory response in Caco-2 cells2016

    • Author(s)
      Tada-Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Suzuki Y, Murakami M, Izuoka K, Chang J, Wu W, Yamada Y, Ichihara S
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 17 Issue: 4 Pages: 576-576

    • DOI

      10.3390/ijms17040576

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15236, KAKENHI-PROJECT-26293149, KAKENHI-PROJECT-25460798, KAKENHI-PROJECT-15H04772, KAKENHI-PROJECT-16H02965, KAKENHI-PROJECT-26305023, KAKENHI-PROJECT-26670329
  • [Journal Article] Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy2016

    • Author(s)
      Shota Sasagawa, Yuhei Nishimura, Shiko Okabe, Soichiro Murakami, Yoshifumi Ashikawa, Mizuki Yuge, Koki Kawaguchi, Reiko Kawase, Ryuji Okamoto, Masaaki Ito and Toshio Tanaka
    • Journal Title

      Frontiers in pharmacology

      Volume: 7 Pages: 162-162

    • DOI

      10.3389/fphar.2016.00162

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08547
  • [Journal Article] DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina2016

    • Author(s)
      Shota Sasagawa, Yuhei Nishimura, Tetsuo Kon, Yukiko Yamanaka, Soichiro Murakami, Yoshifumi Ashikawa, Mizuki Yuge, Shiko Okabe, Koki Kawaguchi, Reiko Kawase and Toshio Tanaka
    • Journal Title

      Front. Pharmacol.

      Volume: 7

    • DOI

      10.3389/fphar.2016.00057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish.2016

    • Author(s)
      Zhang B, Shimada Y, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T.
    • Journal Title

      Transl Res.

      Volume: 170 Pages: 89-98

    • DOI

      10.1016/j.trsl.2015.12.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Using zebrafish in systems toxicology for developmental toxicity testing.2016

    • Author(s)
      Nishimura Y, Inoue A, Sasagawa S, Koiwa J, Kawaguchi K, Kawase R, Maruyama T, Kim S, Tanaka T.
    • Journal Title

      Congenit Anom (Kyoto).

      Volume: 56 Issue: 1 Pages: 18-27

    • DOI

      10.1111/cga.12142

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish.2016

    • Author(s)
      Sasagawa S, Nishimura Y, Koiwa J, Nomoto T, Shintou T, Murakami S, Yuge M, Kawaguchi K, Kawase R, Miyazaki T, Tanaka T.
    • Journal Title

      ACS Chem Biol.

      Volume: 11 Issue: 2 Pages: 381-388

    • DOI

      10.1021/acschembio.5b00751

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs2016

    • Author(s)
      Atsuto Inoue, Yuhei Nishimura, Norihito Matsumoto, Noriko Umemoto , Yasuhito Shimada, Toru Maruyama, Kana Kayasuga, Motohiko Morihara, Jun Katagi, Tsutomu Shiroya, Yasushi Hirota, Soonih Kim , Toshio Tanaka
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 3 Pages: 79-87

    • NAID

      130005140185

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.2015

    • Author(s)
      Nishimura Y, Sasagawa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T.
    • Journal Title

      Front Pharmacol.

      Volume: 6

    • DOI

      10.3389/fphar.2015.00199

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Zebrafish as a systems toxicology model for developmental neurotoxicity testing.2015

    • Author(s)
      Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
    • Journal Title

      Congenit Anom (Kyoto).

      Volume: 55 Issue: 1 Pages: 1-16

    • DOI

      10.1111/cga.12079

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127
  • [Journal Article] In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3)2015

    • Author(s)
      Beibei Zhang, Yasuhito Shimada, Junya Kuroyanagi, Michiko Ariyoshi, Tsuyoshi Nomoto, Taichi Shintou, Noriko Umemoto,Yuhei Nishimura, Takeshi Miyazaki, Toshio Tanaka
    • Journal Title

      Biomaterials

      Volume: 52 Pages: 14-25

    • DOI

      10.1016/j.biomaterials.2015.02.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish.2015

    • Author(s)
      Chang J, Ichihara G, Shimada S, Tada-Oikawa S, Suzuki Y, Radwa S, Kato M, Tanaka T, Ichihara S.
    • Journal Title

      J Nanosci Nanotechnol

      Volume: 15 Pages: 2140-2147

    • NAID

      130004676483

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293149
  • [Journal Article] Downregulation of Stanniocalcin 1 is Responsible for Sorafenib-Induced Cardiotoxicity2015

    • Author(s)
      Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T.
    • Journal Title

      Toxicological Siences

      Volume: 143 Issue: 2 Pages: 374-384

    • DOI

      10.1093/toxsci/kfu235

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish throufg down-regulation of VEGF expression and induction of apoptosis2015

    • Author(s)
      J. Chang, G. Ichihara, Y. Shimada, S. Tada-Oikawa, J. Kuroyanagi, B. Zhang, Y. Suzuki, R. Sehsah, M. Kato, T. Tanaka, S. Ichihara
    • Journal Title

      J Nanosci Nanotechnol

      Volume: 15 Issue: 3 Pages: 2140-2147

    • DOI

      10.1166/jnn.2015.9762

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-25670127
  • [Journal Article] Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers2015

    • Author(s)
      Nishimura Y, Okabe S, Sasagawa S, Murakami S, Ashikawa Y, Yuge M, Kawaguchi K, Kawase R,Tanaka T.
    • Journal Title

      Front Pharmacol.

      Volume: 6

    • DOI

      10.3389/fphar.2015.00257

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Journal Article] Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors.2014

    • Author(s)
      Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T.
    • Journal Title

      Tumour Biology

      Volume: 35 Issue: 12 Pages: 11861-11869

    • DOI

      10.1007/s13277-014-2417-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression2014

    • Author(s)
      Junya Kuroyanagi, Yasuhito Shimada, Beibei Zhang, Michiko Ariyoshi, Noriko Umemoto, Yuhei Nishimura, Toshio Tanaka
    • Journal Title

      FEBS Letters

      Volume: 588 Issue: 18 Pages: 3409-3416

    • DOI

      10.1016/j.febslet.2014.07.033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis2014

    • Author(s)
      Masanori Hiramitsu, Yasuhito Shimada,Junya Kuroyanagi,Takashi Inoue,Takao Katagiri,Liqing Zang,Yuhei Nishimura,Norihiro Nishimura & Toshio Tanaka
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 3708-3708

    • DOI

      10.1038/srep03708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
  • [Journal Article] In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion.2014

    • Author(s)
      Yata K, Nishimura Y, Unekawa M, Tomita Y, Suzuki N, Tanaka T, Mizoguchi A, Tomimoto H.
    • Journal Title

      Stroke.

      Volume: 45 Issue: 12 Pages: 3698-3703

    • DOI

      10.1161/strokeaha.114.005891

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24500422, KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-26350981
  • [Journal Article] Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation2014

    • Author(s)
      Beibei Zhang,Yasuhito Shimada,Junya Kuroyanagi,Noriko Umemoto,Yuhei Nishimura,Toshio Tanaka
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 1 Pages: e85439-e85439

    • DOI

      10.1371/journal.pone.0085439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model2014

    • Author(s)
      Liqing Zang, Yasuhito Shimada, Jumpei Kawajiria, Toshio Tanaka, Norihiro Nishimura
    • Journal Title

      Journal of Functional Foods

      Volume: 10 Pages: 499-510

    • DOI

      10.1016/j.jff.2014.08.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
  • [Journal Article] Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish.2013

    • Author(s)
      Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T.
    • Journal Title

      Molecular Biotechnology

      Volume: 55 Issue: 2 Pages: 131-142

    • DOI

      10.1007/s12033-013-9664-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
  • [Journal Article] Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models.2013

    • Author(s)
      Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T.
    • Journal Title

      ACS Chem Neurosci.

      Volume: 4 Issue: 8 Pages: 1183-1193

    • DOI

      10.1021/cn400010t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127
  • [Journal Article] A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish.2013

    • Author(s)
      Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N.
    • Journal Title

      Zebrafish

      Volume: 10 Issue: 3 Pages: 425-432

    • DOI

      10.1089/zeb.2012.0862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
  • [Journal Article] Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.2013

    • Author(s)
      Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T.
    • Journal Title

      International Journal of Obesity (Lond)

      Volume: 217 Issue: 8 Pages: 1-8

    • DOI

      10.1038/ijo.2013.217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Journal Article] S-nitrosylation regulates mitochondrial quality control via activation of2013

    • Author(s)
      Ozawa K , Komatsubara AT, Nishimura Y, Sawada T, Kawafune H, Tsumoto H, Tsuji Y, Zhao J, Kyotani Y, Tanaka T, Takahashi R, Yoshizumi M
    • Journal Title

      Scientific Reports

      Volume: 3: 2202 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep02202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590306, KAKENHI-PROJECT-25670127
  • [Journal Article] In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.2012

    • Author(s)
      Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T.
    • Journal Title

      BMC Neuroscience

      Volume: 13 Issue: 1 Pages: 101-101

    • DOI

      10.1186/1471-2202-13-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Journal Article] A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening2012

    • Author(s)
      Shimada Y, Hirano M, Nishimura Y,Tanaka T
    • Journal Title

      PLoS ONE

      Volume: 7(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening2012

    • Author(s)
      Shimada Y, Hirano M, Nishimura Y, Tanaka T
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 12 Pages: e52549-e52549

    • DOI

      10.1371/journal.pone.0052549

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136, KAKENHI-PROJECT-24590318
  • [Journal Article] Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish2012

    • Author(s)
      Takahiro Hasumura, Yasuhito Shimada,Junya Kuroyanagi, Yuhei Nishimura,Shinichi Meguro, Yoshinori Takema and Toshio Tanaka
    • Journal Title

      Nutrition & Metabolism

      Volume: 9 Pages: 73-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish2012

    • Author(s)
      Takahiro Hasumura, Yasuhito Shimada, Junya Kuroyanagi,Yuhei Nishimura, Shinichi Meguro, Yoshinori Takema and Toshio Tanaka
    • Journal Title

      Nutrition & Metabolism

      Volume: 9 Issue: 1 Pages: 73-73

    • DOI

      10.1186/1743-7075-9-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model.2011

    • Author(s)
      Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T.
    • Journal Title

      Nutrition & metabolism

      Volume: 8 Issue: 1 Pages: 88-88

    • DOI

      10.1186/1743-7075-8-88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] A novel protocol for the oral administration of test chemicals to adultz zebrafish2011

    • Author(s)
      Liqing Zang, Daizo Morikane, Yasuhito Shimada, Toshio Tanaka, and Norihiro Nishimura
    • Journal Title

      Zebrafish December

      Volume: 8(4) Pages: 203-210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] A novel protocol for the oral administration of test chemicals to adult zebrafish.2011

    • Author(s)
      Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N.
    • Journal Title

      Zebrafish

      Volume: 8 Issue: 4 Pages: 203-220

    • DOI

      10.1089/zeb.2011.0726

    • NAID

      120005228797

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Journal Article] Changes in Cyclic Nucleotide Phosphodiesterase Activity and Calmodul in Concentration in Heart Muscle of Cardiomyopathic Hamsters.2004

    • Author(s)
      Rumi Masunaga, Akio Nagasaka, Yoshikuni Sawai, Nobuki Hayakawa, Akira Nakai, Keiko Hotta, Yasuchika Kato, Hitoshi Hishida, Hisahide Takahashi, Michiko Naka, Yasuhito Shimada, Toshio Tanaka, Hiroyoshi Hidaka, Mitsuyasu Itoh
    • Journal Title

      J Mol Cell Cardiol. 37(3)

      Pages: 767-774

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Journal Article] Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.2004

    • Author(s)
      Hirofumi Nikaido, Hiroshi Tsunoda, Yuhei Nishimura, Takaaki Kirino, Toshio Tanaka
    • Journal Title

      Circulation 110(13)

      Pages: 1839-1846

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Journal Article] ファーマコジェノミックスと創薬ターゲットバリデーション2004

    • Author(s)
      田中利男
    • Journal Title

      癌治療と宿主 16・4

      Pages: 307-313

    • Data Source
      KAKENHI-PROJECT-16659137
  • [Journal Article] ファーマコゲノミクスとファーマコインフォマティクス2004

    • Author(s)
      田中利男
    • Journal Title

      月刊薬事 46・6

      Pages: 37-44

    • Data Source
      KAKENHI-PROJECT-16659137
  • [Journal Article] Target validation in hypoxia-induced vascular remodeling using transcriptome/metabolome analysis.2003

    • Author(s)
      H.Amano, K Maruyama, Michiko Naka, T Tanaka
    • Journal Title

      Pharmacogenomics J 3(3)

      Pages: 183-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Journal Article] Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene.2002

    • Author(s)
      M.Hayashi, Y.Shimada, Y.Nishimura, T.Hama, T.Tanaka
    • Journal Title

      Biochem.Biophys.Res.Commun. 297

      Pages: 1253-1258

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Journal Article] Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis.2002

    • Author(s)
      Matsumoto Y, Oshida T, Obayashi I, Imai Y, Matsui K, Yoshida NL, Nagata N, Ogawa K, Obayashi M, Kashiwabara T, Gunji S, Nagasu T, Sugita Y, Tanaka T, Tsujimoto G, Katsunuma T, Akasawa A, Saito H.
    • Journal Title

      Int Arch Allergy Immunol 129(4)

      Pages: 327-340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Journal Article] Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.2002

    • Author(s)
      Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 297

      Pages: 1282-1290

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207003
  • [Patent] 養殖魚類、畜産動物、ペット動物の内臓脂肪蓄積を抑制する素材、及び該素材を用いた動物用飼料2014

    • Inventor(s)
      田中 利男,島田 康人,國永 史生,椎名 康彦,高橋 義宜
    • Industrial Property Rights Holder
      田中 利男,島田 康人,國永 史生,椎名 康彦,高橋 義宜
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-14
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Patent] イメージング用小魚管理装置及びそれに用いられる小魚用イメージングプレート2014

    • Inventor(s)
      田中 利男,島田 康人,梅本 紀子,小幡 勝,橋本 正敏
    • Industrial Property Rights Holder
      田中 利男,島田 康人,梅本 紀子,小幡 勝,橋本 正敏
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-150299
    • Filing Date
      2014-07-24
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Patent] がん細胞阻害薬、がん幹細胞検出用プローブ2013

    • Inventor(s)
      田中利男,島田康人,西村有平,新藤太一,渡邉耕平,野本毅
    • Industrial Property Rights Holder
      田中利男,島田康人,西村有平,新藤太一,渡邉耕平,野本毅
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-25
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Patent] 異種細胞移植モデル動物の作製方法2013

    • Inventor(s)
      田中 利男,島田 康人,張 貝貝,黒栁 淳哉
    • Industrial Property Rights Holder
      田中 利男,島田 康人,張 貝貝,黒栁 淳哉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-18
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] ヒト膀胱癌ゼブラフィッシュ異種移植モデルの樹立2023

    • Author(s)
      杉野友亮、景山拓海、佐々木豪、井上貴博、田中利男
    • Organizer
      第32回 泌尿器科分子・細胞研究会
    • Data Source
      KAKENHI-PROJECT-21H03066
  • [Presentation] ゼブラフィッシュ発生毒性トランスクリプトームのLSKB/AI(BERT)解析2023

    • Author(s)
      田中利男
    • Organizer
      第50回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-21H02670
  • [Presentation] 新しいハイスループット個別蛋白尿治療薬スクリーニングシステムの構築と応用2023

    • Author(s)
      田中利男
    • Organizer
      第9回ゼブラフィッシュ・メダカ創薬研究会 (ZMDD2023)
    • Data Source
      KAKENHI-PROJECT-21H02670
  • [Presentation] ゼブラフィッシュ創薬とグローバル展開2023

    • Author(s)
      田中利男
    • Organizer
      日本実験動物技術者協会東海北陸支部第9回春季大会 『医療を支える実験動物』
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02670
  • [Presentation] ゼブラフィッシュ心毒性試験からoncocardiologyへの展開2022

    • Author(s)
      田中利男
    • Organizer
      第49回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-21H02670
  • [Presentation] Prognostic impact of preoperative psoas muscle Hounsfield unit at radical cystectomy for bladder cancer.2021

    • Author(s)
      Sugino Yusuke、Sasaki Takeshi、Kato Manabu、Masui Satoru、Nishikawa Kouhei、Okamoto Takashi、Kajiwara Shinya、Shibahara Takuji、Onishi Takehisa、Tanaka Shiori、Kanda Hideki、Matsuura Hiroshi、Inoue Takahiro
    • Organizer
      The 37th Korea-Japan Urological Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03066
  • [Presentation] 新規線毛症モデルゼブラフィッシュの作出2018

    • Author(s)
      西村有平、笠原広介、青木啓将、清野透、王淑杰、弓削瑞葵、白水崇、田中利男、溝口明、五島直樹、稲垣昌樹
    • Organizer
      第4回ゼブラフィッシュ・メダカ創薬研究会
    • Data Source
      KAKENHI-PROJECT-16K08547
  • [Presentation] 新規嚢胞性腎疾患モデルゼブラフィッシュの開発2018

    • Author(s)
      西村有平、笠原広介、青木啓将、清野透、王淑杰、弓削瑞葵、白水崇、田中利男、溝口明、五島直樹、稲垣昌樹
    • Organizer
      第28回日本循環薬理学会
    • Data Source
      KAKENHI-PROJECT-16K08547
  • [Presentation] トランスクリプトームを利用した肺高血圧の病態解析2018

    • Author(s)
      西村有平、澤田博文、田中利男、三谷義英、丸山一男
    • Organizer
      第47回日本心脈管作動物質学会年会シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08547
  • [Presentation] Differentially Expressed Genes in Early and Late Treatment for Occlusive Pulmonary Vasculopathy in Sugen/hypoxia Models: Molecular Basis for Early Treatment2017

    • Author(s)
      Yoshihide Mitani, Hirofumi Sawada, Tsutomu Shinohara, Shoichiro Otsuki, Noriko Yodoya, Hiroyuki Ohashi, Taichi Kato, Erquan Zhang, Yuhei Nishimura, Toshio Tanaka, Kazuo Maruyama, Masahiro Hirayama.
    • Organizer
      American Heart Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09688
  • [Presentation] トランスレーショナル薬理学とゼブラフィッシュ創薬2016

    • Author(s)
      田中利男
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] Zebrafish-Based Drug Discovery and Systems Pharmacology2016

    • Author(s)
      田中利男
    • Organizer
      International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県・岡崎市)
    • Year and Date
      2016-03-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] 肥大型心筋症の新規関連遺伝子GSTK1の発見と機能解析2016

    • Author(s)
      西村有平、笹川翔太、岡部志功、村上宗一郎、芦川芳史、弓削瑞葵、川口幸輝、島田康人、岡本隆二、伊藤正明、田中利男
    • Organizer
      第26回日本循環薬理学会
    • Place of Presentation
      信州大学(長野県・松本市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-16K08547
  • [Presentation] ゼブラフィッシュ創薬と個別化医療の新展開2015

    • Author(s)
      田中利男
    • Organizer
      第62回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都府・京都市)
    • Year and Date
      2015-05-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] ゼブラフィッシュによるシステムズ栄養学のグローバル展開2015

    • Author(s)
      田中利男
    • Organizer
      第69回日本栄養・食糧学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-05-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] システムズ薬理学とゼブラフィッシュ創薬2015

    • Author(s)
      田中利男
    • Organizer
      第21回小型魚類研究会
    • Place of Presentation
      大阪大学銀杏会館(大阪府・吹田市)
    • Year and Date
      2015-09-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] High Throughput Forward and Reverse Screen for Cardiotoxicology of Anticancer Drugs in Zebrafish2015

    • Author(s)
      田中利男
    • Organizer
      ZDM8
    • Place of Presentation
      Boston(アメリカ合衆国)
    • Year and Date
      2015-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] ゼブラフィッシュ創薬の新しい展開2015

    • Author(s)
      田中利男
    • Organizer
      第1回ゼブラフィッシュ創薬研究会
    • Place of Presentation
      三重大学(三重県・津市)
    • Year and Date
      2015-11-06
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] 次世代ゼブラフィッシュ創薬の新展開2015

    • Author(s)
      田中利男
    • Organizer
      第88回日本薬理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] ゼブラフィッシュを用いた創薬スクリーニング2015

    • Author(s)
      西村有平、川瀬玲子、田中利男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] ゼブラフィッシュ創薬の国際的展開2015

    • Author(s)
      田中利男
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] Systems Pharmacology for Retinal Diseases2015

    • Author(s)
      Nishimura Y, Kawase R, Tanaka T
    • Organizer
      The 88th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] 分子標的薬の心毒性に関するシステムズ薬理学2015

    • Author(s)
      田中利男
    • Organizer
      第2回Onco-Cardiology Meeting
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都・千代田区)
    • Year and Date
      2015-10-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15051
  • [Presentation] 遺伝子改変ゼブラフィッシュを用いたニコチンの発達神経毒性評価2014

    • Author(s)
      西村有平、村上宗一郎、芦川芳史、笹川翔太、川端美湖、梅本紀子、有吉美稚子、張貝貝、島田康人、田中利男
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-03
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] ゼブラフィッシュを用いたBBB機能イメージング2014

    • Author(s)
      西村有平、梅本紀子、田中利男
    • Organizer
      第9回トランスポーター研究会年会
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] ゼブラフィッシュによる医薬品の生殖発生毒性評価2014

    • Author(s)
      西村有平、田中利男、島田康人、梅本紀子
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] 医薬品の生殖発生毒性評価のためのパラダイムシフト2014

    • Author(s)
      田中利男
    • Organizer
      第41回日本毒性学会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] Biodistribution and effects of SiO2 NPs in mice and in a transgenic model of zebrafish (Danio rerio).2014

    • Author(s)
      Sandra Vranic, Sahoko Ichihara, Yasuhito Shimada, Toshio Tanaka, Wenting Wu, Sonja Boland, Lang Tran, Gaku Ichihara
    • Organizer
      The 7th International Congress of Nanotoxicology
    • Place of Presentation
      The Congress Center in Limra Hotel & Resort, Antalya, Turkey
    • Year and Date
      2014-04-23
    • Data Source
      KAKENHI-PROJECT-26293149
  • [Presentation] ターゲットバリデーションとオミックス創薬スクリーニング2011

    • Author(s)
      田中 利男
    • Organizer
      ゲノム創薬フォーラム 談話会(招待講演)
    • Place of Presentation
      日本薬学会館 長井記念ホール
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] オミックス創薬科学におけるターゲットバリデーション2011

    • Author(s)
      田中 利男
    • Organizer
      第84回日本生化学会大会(招待講演)
    • Place of Presentation
      京都国際会館
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] 新しい生活習慣病モデルとオミックス医学2011

    • Author(s)
      田中 利男
    • Organizer
      第134回分泌セミナー(招待講演)
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] ターゲットバリテーションとオミックス創薬スクリーニング2011

    • Author(s)
      田中 利男
    • Organizer
      ゲノム創薬フォーラム
    • Place of Presentation
      日本薬学会館 長井記念ホール
    • Year and Date
      2011-11-09
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] オミックス創薬科学におけるターゲットバリテーション2011

    • Author(s)
      田中 利男
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] 新しい生活習慣病モデルとオミックス医学2011

    • Author(s)
      田中 利男
    • Organizer
      第134回分泌セミナー
    • Place of Presentation
      東京都 ノボ ノルディスクファーマ(株)
    • Year and Date
      2011-09-03
    • Data Source
      KAKENHI-PROJECT-23659136
  • [Presentation] ゼブラフィッシュを用いた医薬品の安全性評価

    • Author(s)
      田中利男
    • Organizer
      第117回基礎研究部会総会
    • Place of Presentation
      京都リサーチパーク
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] バルプロ酸による催奇形性のシステムズ薬理学

    • Author(s)
      村上宗一郎、西村有平、笹川翔太、芦川芳史、川端美湖、張貝貝、島田康人、梅本紀子、田中利男
    • Organizer
      第54回日本先天異常学会学術年会
    • Place of Presentation
      麻布大学
    • Year and Date
      2014-07-26 – 2014-07-27
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] ゼブラフィッシュを用いた新しい発達神経毒性評価システム

    • Author(s)
      西村有平、島田康人、田中利男
    • Organizer
      日本先天異常学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] ゼブラフィッシュによる新しい網膜保護機構解析

    • Author(s)
      西村有平、梅本紀子、田中利男
    • Organizer
      第34回日本眼薬理学会年会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2014-09-13 – 2014-09-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] 希少疾患と創薬

    • Author(s)
      田中利男
    • Organizer
      ゲノム創薬フォーラム第33回談話会
    • Place of Presentation
      東大医科研講堂
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] ターゲットバリデ―ションとシステム薬理学

    • Author(s)
      田中利男
    • Organizer
      Shikoku Synphony研究会
    • Place of Presentation
      徳島
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] ゼブラフィッシュによろ定量的システムズ薬理学

    • Author(s)
      田中利男
    • Organizer
      第46回筑波実験動物研究会
    • Place of Presentation
      文科省研究交流センター
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] In vivo fluorescent imaging of blood-brain barrier disruption in zebrafish using a novel dye.

    • Author(s)
      Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
    • Organizer
      DNT4
    • Place of Presentation
      The Inn at Penn, Philadelphia, PA
    • Year and Date
      2014-05-11 – 2014-05-16
    • Data Source
      KAKENHI-PROJECT-24510069
  • [Presentation] 中枢神経系のゼブラフィッシュ安全性システムズ薬理学

    • Author(s)
      田中利男
    • Organizer
      第5回日本安全性薬理研究会学術年会
    • Place of Presentation
      東京大学弥生講堂一条ホール
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670127
  • [Presentation] マウスと遺伝子改変ゼブラフィッシュにおけるシリカナノ粒子の生態分布と影響

    • Author(s)
      ブラニッチ サンドラ、市原 佐保子、島田康人、田中利男、呉文亭、ボーランド ソニア、トラン ラン、市原学
    • Organizer
      第84回日本衛生学会総会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Data Source
      KAKENHI-PROJECT-26293149
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