Nagafuchi Seiho 永淵正法

… Alternative Names

NAGAFUCHI Seiho 永淵正法

永渕正法ナガフチセイホウ

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Researcher Number	00150441
Other IDs
Affiliation (Current)	2025: 佐賀大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 佐賀大学, 医学部, 特任教授 2016 – 2017: 佐賀大学, 医学部, 客員研究員 2011 – 2015: 九州大学, 医学(系)研究科(研究院), 教授 2009 – 2011: Kyushu University, 医学研究院, 教授 2007 – 2011: Kyushu University, 大学院・医学研究院, 教授 … More 2005 – 2006: 九州大学, 医学部, 教授 2000 – 2003: 九州大学, 医療技術短期大学部, 教授 2001: Kyusyu University, School of Health Science, Professor, 医療技術短期大学, 教授 1991 – 1997: 九州大学, 医学部, 助手 1992: Kyushu Univ.Fac.Med.Assistant Prof., 歯学部, 助手 1987 – 1988: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics / Basic Section 54030:Infectious disease medicine-related / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Metabolomics / Laboratory animal science / Endocrinology / 内科学一般 / Legal medicine
Keywords	Principal Investigator 糖尿病 / 膵島炎 / Bリンパ球 / 自己免疫 / NODマウス / インターフェロン / ウイルス / 膵島細胞 / lprマウス / autoimmunity … More / B lymphocytes / insulitis / NOD mouse / diabetes / インスリン / 抗原提示 / B細胞 / Tリンパ球 / 自己免疫調節遺伝子(Aire) / 膵島 / 感染防御 / 発症制御機構 / チロシンキナーゼ / 遺伝子 / 感受性 / ２型糖尿病 / １型糖尿病 / エンテロウイルス / コクサッキーBウイルス / エンテロウイルス受容体 / Stat2 / チロシンキナーゼ２ / 脳心筋炎ウイルス / stat / Tyrosine kinase 2 / Stat / Tyrosine kinase 2 (Tyk2) / 感受性遺伝子 / apoptosis / macrophages / pancreatic islet / virus / tyk-2 / シグナル伝達 / 細胞・組織 / 免疫学 / シグナル伝達分子 / NOD MOUSE / BLYMPHOCYTES / INSULITIS / DIABETES / lpvマウス / ノックアウトマウス / Diabetes / STO細胞 / Embryonic stem cell / immunoglobulin subclass / anti-Phospholipid Ab / Glutamic acid Decarboxylase / GAD / Glutamic Acid docarboxylase / 免疫グロブリンサブクラス / 抗リン脂質抗体 / Glutamic Acid Decarboxylase / Protein Isomerase / 自己免疫性膵炎 / Disulfide Isomerase / 自己免疫疾患 / 自己抗体 / 自己免疫調節遺伝子 / 膵臓炎 / 1型糖尿病 / 自己免疫膵炎 / 自己免疫調節(AIRE)遺伝子 / 単純ヘルペスウイルス / 慢性自己免疫性膵炎 / 免疫沈降 / カンジダ / 感染症学 / 樹状細胞 / T細胞 / microRNA / カンジダ感染 / 自己免疫調節遺伝子(AIRE) / 自己免疫性多腺性内分泌不全症・カンジダ症 / アポトーシス … More Except Principal Investigator 糖尿病 / CBP / AIRE / APS-1 / APECED / REGⅠα / インスリン / BrdU / REGIα / EMCウイルス / 再生医学 / ウイルス / 膵ベータ細胞再生 / disease model mice / ES cells / embryo cloning / mdx mice / dy mice / NOD mice / 筋ジストロフィー / クローン / マウス / Dendritic cells / Antigen presenting cells / Thymus / Autoimmune disease / 転写調節因子 / RelB / 免疫応答 / トランスジェニックマウス / SV40T抗原 / 樹状細胞 / 抗原提示細胞 / 胸腺 / 自己免疫疾患 / anti-mitochondrial antibody / T cell epitope / B cell epitope / peptide based vaccine / neutralizing epitope / anti-HTLV-1 antibody / human monoclonal antibody / B lymphocyte repertoire / T-cell エピトープ / B cell エピトープ / 抗HTLV-I抗体 / T Cell エピトープ / B Cell エピトープ / 抗HTLV-1 抗体 / 抗ミトコンドリア抗体 / T-cellエピトープ / B cellエピトープ / ペプチドワクチン / 中和エピトープ / 抗HTLV-1抗体 / ヒト型モノクローナル抗体 / Bリンパ球レパートリー / オリゴペプチド / 高分子 / 低分子 / サイトカイン / 腫瘍増殖制御因子 / 細胞増殖制御 / 再生医療 / 膵ベータ細胞 Less

The significance and the mechanisms of virus-induced diabetes susceptibility genesPrincipal Investigator
- Principal Investigator
  
  Nagafuchi Seiho
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Saga University
Epigenetic regulation of development and maturation processes in pancreatic beta cells
- Principal Investigator
  
  KATSUTA HITOSHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Physiological and pathophysilogical roles of acinar-like cell cluster touching Langerhans islet with thin interstitial surrounding (ATLANTIS) on regeneration and maintenance of beta cell.
- Principal Investigator
  
  Kobayashi Tetsuro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Okinaka Memorial Institute for Medical Research
Clinical significance of anti-disulfide isomerase based on the AIRE researchPrincipal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyushu University
Regeneration of pancreatic beta-cell from pancreatic SP cell
- Principal Investigator
  
  KATSUTA HITOSHI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Analysis of regulatory mechanisms of type 1 diabetes by B cells, based on the AIRE researchPrincipal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
The mechanisms for the deterioration of infection control in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)Principal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyushu University
ウィルス糖尿病高感受性マウスの開発Principal Investigator
- Principal Investigator
  
  永淵正法
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Kyushu University
Pathogenesis of virus induced diabetesPrincipal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  KYUSHU UNIVERSITY
Practical use of cloning technology for NOD and dy disease model mice production
- Principal Investigator
  
  KONO Tomohiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  TOKYO UNIVERSITY OF AGRICULTURE
Roles of the Autoimmune Regulator (AIRE) Gene in Immune Response
- Principal Investigator
  
  SHIMIZU Nobuyoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
ANALYSIS OF SUPPRESSION OF AUTOIMMUNE DIABETES IN B-CELL DEFICIENT NOD MICE.Principal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYUSHU UNIVERSITY
Functional analysis of infiltrating lymphocytes in islets of NODmice by using gene targeting.Principal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyushu University
Identification of HTLV-1 neutralizing epitopes and the development of an HTLV-1 peptide based vaccine
- Principal Investigator
  
  NAKAMURA Minoru
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kyushu University
Functional analysis of infiltrating lymphocytes to islets in NOD micPrincipal Investigator
- Principal Investigator
  
  NAGAFUCHI Seiho
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYUSHU UNIVERSITY
癌細胞における増殖抑制因子の純化とそれによる癌細胞の増殖機構の解析
- Principal Investigator
  
  NAKANO Shuji
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Kyushu University

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All Journal Article Presentation Book

[Book] グローバル化した保健と医療:アジアの発展と疾病の変化2011
- Author(s)
  永淵正法
- Publisher
  国際書院
- Data Source
  KAKENHI-PROJECT-21659230
[Book] 糖尿病治療ハンドブック2010
- Author(s)
  永淵正法、安西慶三、南昌江、滝井正人、樗木晶子、近藤しおり、久保千春
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-19209037
[Book] 糖尿病治療ハンドブック2010
- Author(s)
  永淵正法、安西慶三、南昌江、滝井正人、樗木晶子、近藤しおり、久保千春
- Total Pages
  317
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-21659230
[Book] 糖尿病治療ハンドブック2010
- Author(s)
  永淵正法、安西慶二、南昌江、滝井正人、樗木晶子、近藤しおり、久保千春
- Total Pages
  317
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-19209037
[Book] 編集代表糖尿病治療ハンドブック2010
- Author(s)
  永淵正法
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.2021
- Author(s)
  Mori H, Takahashi H, Mine K, Higashimoto K, Inoue K, Kojima M, Kuroki S, Eguchi T, Ono Y, Inuzuka S, Soejima H, Nagafuchi S, Anzai K.
- Journal Title
  
  Genes (Basel).
  
  Volume: 12 Issue: 3 Pages: 400-400
- DOI
  10.3390/genes12030400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-18H02853, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-21K19451
[Journal Article] Genetic Susceptibility of the Host in Virus-Induced Diabetes.2020
- Author(s)
  Mine K, Yoshikai Y, Takahashi H, Mori H, Anzai K, Nagafuchi S.
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 8 Pages: 1133-1133
- DOI
  10.3390/microorganisms8081133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02853, KAKENHI-PLANNED-16H06496
[Journal Article] Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice.2020
- Author(s)
  Mine, K.; Nagafuchi, S.; Hatano, S.; Tanaka, K.; Mori, H.; Takahashi, H.; Anzai, K.; Yoshikai, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 521 Issue: 4 Pages: 853-860
- DOI
  10.1016/j.bbrc.2019.10.193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02853, KAKENHI-PROJECT-17J03060, KAKENHI-PLANNED-16H06496
[Journal Article] ウイルス感染と糖尿病2019
- Author(s)
  三根敬一朗、永淵正法、吉開泰信
- Journal Title
  
  日本臨牀
  
  Volume: 別冊　内分泌症候群（第3版） Pages: 84-88
- Data Source
  KAKENHI-PROJECT-18H02853
[Journal Article] Viruses with masked pathogenicity and genetically susceptible hosts -How to discover potentially pathogenic viruses.2019
- Author(s)
  Nagafuchi S, Mine K, Takahashi H, Anzai K, and Yoshikai Y.
- Journal Title
  
  J Med Virol
  
  Volume: 印刷中 Issue: 8 Pages: 1365-1367
- DOI
  10.1002/jmv.25472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-17J03060, KAKENHI-PROJECT-18H02853
[Journal Article] ウイルス感染と糖尿病2019
- Author(s)
  三根敬一朗、永淵正法、吉開泰信
- Journal Title
  
  別冊　日本臨牀　内分泌症候群
  
  Volume: 第3版 Pages: 84-88
- Data Source
  KAKENHI-PROJECT-18H02853
[Journal Article] Viruses with masked pathogenicity and genetically susceptible hosts―How to discover potentially pathogenic viruses.2019
- Author(s)
  Nagafuchi, S.; Mine, K.; Takahashi, H.; Anzai, K.; Yoshikai, Y.
- Journal Title
  
  J. Med. Virol.
  
  Volume: 91 Pages: 1365-1467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02853
[Journal Article] Model Animal Mimicking Human Virus-induced Diabetes2018
- Author(s)
  Mine Keiichiro、Takahashi Hirokazu、Nagafuchi Seiho
- Journal Title
  
  EBioMedicine
  
  Volume: 32 Pages: 8-8
- DOI
  10.1016/j.ebiom.2018.05.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J03060, KAKENHI-PROJECT-18H02853
[Journal Article] TYK2 Promoter Variant and Diabetes Mellitus in the Japanese2015
- Author(s)
  Seiho Nagafuchi; Yumi Kamada-Hibio; Hitoshi Katsuta, et.al.
- Journal Title
  
  E-Biomedicine
  
  Volume: 未定
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591309
[Journal Article] TYK2 promoter variant and diabetes mellitus in the Japanese.2015
- Author(s)
  Nagafuchi S, Kamada Y, Hirakawa K , Tsutsu N, eet al.
- Journal Title
  
  EBioMedicine
  
  Volume: 2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670461
[Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.2015
- Author(s)
  Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 1-10
- DOI
  10.1038/ncomms7748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591309, KAKENHI-PROJECT-24591401, KAKENHI-PROJECT-25670461, KAKENHI-PROJECT-15K15365, KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-26305014
[Journal Article] Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.2014
- Author(s)
  13.Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.da, T., Hirata, S., Takamatsu, K., Haruta, M., Tsukamoto, H., Ito, T., Uchino, M., Ando, Y., Nagafuchi, S., Nishimura, Y., Senju, S.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e115198-e115198
- DOI
  10.1371/journal.pone.0115198
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300334, KAKENHI-PROJECT-25461499, KAKENHI-PROJECT-25670461, KAKENHI-PROJECT-25870540, KAKENHI-PROJECT-26430165
[Journal Article] Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.2013
- Author(s)
  Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S.
- Journal Title
  
  Gene
  
  Volume: 530 Pages: 19-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670461
[Journal Article] Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN mice.2013
- Author(s)
  Kurisaki H Yukihiro Nagao Y, Nagafuchi S, Mitsuyama M.
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 5 Pages: e82-e82
- DOI
  10.1371/journal.pgen.0030082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670461
[Journal Article] ウイルス感染の免疫防御と自己免疫2011
- Author(s)
  永淵正法、栗崎宏憲、勝田仁
- Journal Title
  
  臨床とウイルス
  
  Volume: 39(1) Pages: 3-9
- NAID
  10028119597
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] ウイルス糖尿病と自己免疫糖尿病2011
- Author(s)
  永淵正法
- Journal Title
  
  臨床と微生物 38(1)
  
  Pages: 57-61
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] ウイルス糖尿病と自己免疫性1型糖尿病2011
- Author(s)
  永淵正法
- Journal Title
  
  臨床と微生物
  
  Volume: 38(1) Pages: 57-61
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] ウイルス糖尿病と自己免疫糖尿病2011
- Author(s)
  永淵正法
- Journal Title
  
  臨床と微生物
  
  Volume: 38(1) Pages: 57-61
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance2011
- Author(s)
  Wada N, Nishifuji K, Nagafuchi S, Amagai M, et al.
- Journal Title
  
  J Investig Dermatol
  
  Volume: 131 Pages: 410-417
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance.2011
- Author(s)
  Wada N, Nishifuji K, Yamada, Kudoh J, Shimizu N, Matsumoto M, Peltonen P, Nagafuchi S, Amagai M.
- Journal Title
  
  J Investig Dermatol 131
  
  Pages: 410-417
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] The role of B cells in regulating the magnitude of immune response.2010
- Author(s)
  Nagafuchi S
- Journal Title
  
  Microbiology and immunology
  
  Volume: 54 Pages: 487-490
- NAID
  10029545471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] B-lymphocyte depletion, and Beta-cell function2010
- Author(s)
  Nagafuchi, S., Katsuta, H., Anzai, K. Rituximab
- Journal Title
  
  N Engl J Med 362
  
  Pages: 761-761
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Different effects of islet transplantation and Detemir treatment on the reversal of streptozotocin induced diabetes ssociated with β cell regeneration.2010
- Author(s)
  Akari Inada, Oogi Inada, Hiroshi Fujii, Tomoyuki Akashi, Katsuo Sueishi, Atsushi Fukatsu, Seiho Nagafuchi
- Journal Title
  
  Diabetology International 1(1)
  
  Pages: 49-59
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Different effects of islet transplantation and Detemir treatment on the reversal of streptozotocin induced diabetes associated with βcell regeneration2010
- Author(s)
  Inada A, Inada O, Fujii H, Akashi T, Sueishi K., Fukatsu A, Nagafuchi S.
- Journal Title
  
  Diabetology International
  
  Volume: 1(1) Pages: 49-59
- NAID
  10029620830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] Rituximab, B-lymphocyte depletion, Beta Cell Function.2010
- Author(s)
  Nagafuchi S, Katsuta H, Anzai K.
- Journal Title
  
  New England Journal of Medicine 362
  
  Pages: 761-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Rituximab, B-lymphocyte Depletion, Beta-cell Function2010
- Author(s)
  Nagafuchi S, Katsuta H, Anzai K.
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 362 Pages: 761-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] 自己免疫疾患と炎症2010
- Author(s)
  永淵正法、塚本浩、新納宏昭、小林隆志
- Journal Title
  
  細胞工学
  
  Volume: 29(9) Pages: 769-775
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 自己免疫性1型糖尿病とウイルス感染2010
- Author(s)
  永淵正法、近藤しおり
- Journal Title
  
  Diabetes Frontier
  
  Volume: 21(3) Pages: 19-24
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] The role of B cells in regulating the magnitude of immune response2010
- Author(s)
  Nagafuchi S.
- Journal Title
  
  Microbiol Immunol
  
  Volume: 54 Pages: 487-490
- NAID
  10029545471
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] The role of B cells in regulating the magnitude of immune response.2010
- Author(s)
  Nagafuchi S
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 54 Pages: 487-490
- NAID
  10029545471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 自己免疫性1型糖尿病とウイルス感染2010
- Author(s)
  永淵正法、近藤しおり
- Journal Title
  
  Diabetes Frontier 21(3)
  
  Pages: 314-319
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Different effects of islet transplantation and Detemir treatment on the reversal of streptozotocin induced diabetes associated with β cell regeneration2010
- Author(s)
  Inada A, Inada O, Fujii H, Akashi T, Sueishi K, Fukatsu A, Nagafuchi S.
- Journal Title
  
  Diabetology International
  
  Volume: 1(1) Pages: 49-59
- NAID
  10029620830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 自己免疫疾患と炎症2010
- Author(s)
  永淵正法、塚本浩、新納宏昭、小林隆志
- Journal Title
  
  細胞工学 29(9)
  
  Pages: 769-775
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Different effects of islet transplantation and Detemir treatment on the reversal of streptozotocin induced diabetes associated withβcell regeneration2010
- Author(s)
  Inada A, Inada O, Fujii H, Tomoyuki Akashi T, Sueishi K, Fukatsu A, Nagafuchi S.
- Journal Title
  
  Diabetology International
  
  Volume: 1(1) Pages: 49-59
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] B-lymphocyte depletion, and Beta-cell function.2010
- Author(s)
  Nagafuchi S., Katsuta, H., Anzai, K. Rituximab
- Journal Title
  
  N Engl J Med 362
  
  Pages: 761-761
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Rituximab, B-Lympocyte depletion, and beta-cell function2010
- Author(s)
  Nagafuchi S, Katsuta H, Anzai K.
- Journal Title
  
  N Engl J Med 362
  
  Volume: 362(8) Pages: 761-761
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] Rituximab, B-lymphocyte depletion, Beta Cell Function2010
- Author(s)
  Nagafuchi S, Katsuta H, Anzai K.
- Journal Title
  
  New England Journal of Medicine 362
  
  Pages: 761-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] 自己免疫性1型糖尿病とウイルス感染2010
- Author(s)
  永淵正法、近藤しおり
- Journal Title
  
  Diabetes Frontier
  
  Volume: 21(3) Pages: 19-24
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 自己免疫疾患と炎症2010
- Author(s)
  永淵正法、塚本浩、新納宏昭、小林隆志
- Journal Title
  
  細胞工学
  
  Volume: 29(9) Pages: 769-775
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] 糖尿病発症に関るウイルス感染2010
- Author(s)
  永淵正法
- Journal Title
  
  感染症 40(5)
  
  Pages: 19-24
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] The role of B cells in regulating the magnitude of immune response.2010
- Author(s)
  永淵正法
- Journal Title
  
  Microbiol Immunol 54
  
  Pages: 487-490
- NAID
  10029545471
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Rituximab, B-lymphocyte Depletion, Beta-cell Function2010
- Author(s)
  Nagafuchi S, Katsuta H, Anzai K.
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 362 Pages: 761-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 1型糖尿病の成因:環境因子2009
- Author(s)
  大澤進、永淵正法
- Journal Title
  
  月刊糖尿病
  
  Volume: 1(6) Pages: 31-39
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] 1型糖尿病の成因 : 環境因子2009
- Author(s)
  大澤進、永淵正法
- Journal Title
  
  月刊糖尿病 1(6)
  
  Pages: 31-39
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 1型糖尿病の成因:環境因子2009
- Author(s)
  大澤進、永淵正法
- Journal Title
  
  月刊糖尿病 1(6)
  
  Pages: 31-39
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 1型糖尿病の成因:環境因子2009
- Author(s)
  大澤進, 永淵正法
- Journal Title
  
  月刊糖尿病 1
  
  Pages: 31-39
- Data Source
  KAKENHI-PROJECT-21659230
[Journal Article] 糖尿病発症に関るウイルス感染症-糖尿病ウイルス原因説-2009
- Author(s)
  永淵正法
- Journal Title
  
  月刊糖尿病 1(1)
  
  Pages: 31-39
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 1型糖尿病の成因(3)環境因子.2008
- Author(s)
  永淵正法, 大澤進, 和泉賢一, 栗崎宏憲, 高上悦志ら
- Journal Title
  
  Diabetes Frontier 19
  
  Pages: 180-184
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Enterovirus infection and organ injuries-damage of pancreatic islet cells and induction of diabetes-2007
- Author(s)
  Nagafuchi S, Ogawa S, Kurisaki H.
- Journal Title
  
  Clinical Virology(in Japanese) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] 特異な自己免疫病APECED (autoimmune polyendocrinopathy-candidiasis ectodermal dystrophy)の責任遺伝子AIRE.2007
- Author(s)
  永淵正法、栗崎宏憲
- Journal Title
  
  感染・炎症・免疫 37
  
  Pages: 88-91
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9・1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Shindo M, et al.
- Journal Title
  
  Journal of Internal Medicine (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] 特異な自己免疫病APECED(autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy)の責任遺伝子AIRE2007
- Author(s)
  永淵正法、栗崎宏憲
- Journal Title
  
  感染・炎症・免疫 37
  
  Pages: 88-91
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] 特異な自己免疫病APECED (autoimmune polyendocrinopathy-candidiasis ectodermal dystrophy) の責任遺伝子AIRE2007
- Author(s)
  永淵正法, 栗崎宏憲
- Journal Title
  
  感染・炎症・免疫 37
  
  Pages: 88-91
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] エンテロウイル感染症と臓器障害のメカニズム-膵島障害と糖尿病誘発2007
- Author(s)
  永淵正法、小川秀一郎、栗崎宏憲
- Journal Title
  
  臨床とウイルス 35
  
  Pages: 146-151
- Data Source
  KAKENHI-PROJECT-18659270
[Journal Article] Recurrent herpes simplex Virus infection in a patient with autoimmune polyendocrinonathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Sinndo M, Kurisaki H, Kudoh J, Shimizu N, Hara T, Harada M.
- Journal Title
  
  Journal of Internal Medicine 261
  
  Pages: 605-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Sinndo M, Kurisaki H, Kudoh J, Shimizu N, Hara T, Harada M.
- Journal Title
  
  J Intern Med 261
  
  Pages: 605-610
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9 -1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Sinndo M, Kurisaki H, Kudoh J, Shimizu N, Hara T, Harada M.
- Journal Title
  
  J Intern Med 261
  
  Pages: 605-610
- Data Source
  KAKENHI-PROJECT-19209037
[Journal Article] エンテロウイルス感染症と臓器障害のメカニズム-膵島障害と糖尿病誘発-2007
- Author(s)
  永淵正法, 栗崎宏憲, 小川秀一郎
- Journal Title
  
  臨床とウイルス 35(印刷中)
- NAID
  10019738426
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S et al.
- Journal Title
  
  Journal of Internal Medicine 261
  
  Pages: 605-610
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] エンテロウイルス感染症と臓器障害のメカニズム-膵島障害と糖尿病誘発-2007
- Author(s)
  永淵正法, 栗崎宏憲, 小川秀一郎
- Journal Title
  
  臨床とウイルス 35(印刷中)
- NAID
  10019738426
- Data Source
  KAKENHI-PROJECT-18659270
[Journal Article] Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis -ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations2007
- Author(s)
  Nagafuchi S et al.
- Journal Title
  
  Journal of Internal Medicine 261(in press)
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus-induced diabetes in mice
- Author(s)
  Kounoue E, Izumi K, Ogawa S, Katsuta H, Shindo M, Nagafuchi S, et al.
- Journal Title
  
  Archives of Virology (revised version submitted.)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Journal Article] The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus- induced diabetes in mice
- Author(s)
  Etsushi Kounoue, Hironori Kurisaki, Hitoshi Katsuta, Seih Nagafuchi et al.
- Journal Title
  
  Archives of Virology (Revised version resubmitted)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390265
[Presentation] EMC-Dウイルス誘発糖尿病におけるメスの感受性に関する検討2020
- Author(s)
  三根敬一朗、森仁恵、高橋宏和、吉開泰信、安西慶三、永淵正法
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] NOD マウスにおけるTyk2 遺伝子の意義の解明2020
- Author(s)
  三根敬一朗、吉開泰信、森仁恵、高橋宏和、安西慶三、永淵正法
- Organizer
  第58回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] ウイルス感染時にけるＤＢＡ/2マウス膵β細胞の解析2019
- Author(s)
  三根敬一朗、皆川洋子、永淵正法
- Organizer
  第60回日本臨床ウイルス学会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] Pancreatic beta cell specific reduced Stat2 gene expression isresponsible for serving susceptibility to virus-induced diabetes in DBA/2 mice2019
- Author(s)
  Mine K, Nagafuchi S, Mori, H, Takahashi K, Yoshikai Y, Anzai K.
- Organizer
  55th ANNUAL MEETING EASD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] A Promoter　Variant of TYK2,a Putative Virus-Induced Susceptibility Gene,Is Associated with Impaired Insulin Secretion and Nonobese Type2 Diabetes.2019
- Author(s)
  Mori H, Takahashi H, Mine M, Inoue K, Kojima M, Kuroki S, Ono Y, Inuzuka S, Nagafuchi S, Anzai K.
- Organizer
  Food Security Heart ＆　Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] 新規ウイルス糖尿病感受性遺伝子の同定と発症メカニズムの解析2019
- Author(s)
  三根敬一朗、森仁恵、高橋宏和、吉開泰信、安西慶三、永淵正法
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] EMC-D virus-induced diabetes in DBA/2 mice2018
- Author(s)
  Keiichiro Mine, Seiho Nagafuchi, Hirokazu Takahashi, Yasunobu Yoshikai, Hitoe Mori, Yayoi Matsuda, Keizo Anzai
- Organizer
  54th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] 実験的ウイルス糖尿病研究の進歩とこれからの展開2018
- Author(s)
  永淵正法
- Organizer
  第16回１型糖尿病研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] 2 型糖尿病のインスリン分泌能にTKY2 遺伝子多型が与える影響2018
- Author(s)
  森仁恵，高橋宏和，三根敬一朗，井上佳奈子，松田やよい，小野恭祐，永淵正法，安西慶三
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] 未知のウイルス糖尿病感受性遺伝子の探索ーウイルス糖尿病予防ワクチン開発を目指してー2018
- Author(s)
  永淵正法
- Organizer
  第22回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] TYK2 遺伝子多型，IgE，抗GAD 抗体から考えられた日本人T1D 患者の特徴2018
- Author(s)
  三根敬一朗，永淵正法，南昌江，岡田朗，近藤しおり，平川可南子，日比生由美，小島夫美子，栗崎宏憲，藤本秀士，筒信隆，横川泰，吉開泰信，森仁恵，松田やよい，高橋宏和，安西慶三
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] DBA/2 マウスにおけるウイルス性1 型糖尿病感受性遺伝子の探索2018
- Author(s)
  三根敬一朗，森仁恵，田中賢一，畑野晋也，高橋宏和，吉開泰信，安西慶三，永淵正法
- Organizer
  第56回糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] デュラグルチド導入の契機・効果発揮の時系列が詳細に評価できた一例と12 例の使用報告2018
- Author(s)
  柴山栄梨香，森松恵美子，小田真理，古家成美，北原奈美，藤野みゆき，三枝あずさ，梅野守男，永淵正法
- Organizer
  第56回糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] ヒトウイルス糖尿病感受性遺伝子多型　TYK2 promoter variant(TYK2PV)の同定とその意義2018
- Author(s)
  永淵正法，小島夫美子，藤本秀士，栗崎宏憲，吉開泰信，安西慶三，三根敬一朗，高橋宏和
- Organizer
  第92回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] ウイルス感染による糖尿病発症の遺伝的基盤2018
- Author(s)
  永淵正法，小島夫美子，藤本秀士，栗崎宏憲，吉開泰信，安西慶三，三根敬一朗，高橋宏和
- Organizer
  第56回糖尿病学会九州地方会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02853
[Presentation] ウイルス糖尿病誘発性と宿主の感受性2014
- Author(s)
  永淵　正法
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23591309
[Presentation] Regulatory mechanisms off autoimmune regulator (AIRE) gene and protein expression in central and peripheral immune system2013
- Author(s)
  Morita Y, Matsuo T,Oda Y, Noguchi Y, Kurisaki H, katsuta H, Nagafuchi S
- Organizer
  73rd Annual Meeting of the American Assoiation of Diabtest (ADA), 2013
- Place of Presentation
  Chicago, U.S.A.
- Data Source
  KAKENHI-PROJECT-25670461
[Presentation] The role of TNFa pathway and microRNA in regulating autoimmune regulator gene expression and translatio2013
- Author(s)
  Morita Y, Oda Y, Matsuo T, Kurisaki H, katsuta H, Nagafuchi S
- Organizer
  Immunolgy 2013, The 100th Annual Meeting of the American Assoiation of Immunologist (AAI)
- Place of Presentation
  Honolulu, Hawai, U.S.A.
- Data Source
  KAKENHI-PROJECT-25670461
[Presentation] ウイルス誘発糖尿病におけるTyk2遺伝子の意義2012
- Author(s)
  手嶋美穂, 甲斐裕次, 甲斐克也, 三根敬一朗, 和泉賢一, 栗崎宏憲, 勝田仁, 永淵正法
- Organizer
  日本臨床ウイルス学会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-23591309
[Presentation] ナノコートディッシュ培養マウス由来ES細胞の未分化能の検討2012
- Author(s)
  中島紫, 永淵正法, 勝田仁, 原口和敏
- Organizer
  日本糖尿病学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591309
[Presentation] アフィニティカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRE蛋白の発現解析2011
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、藤田麻子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第54回日本糖尿病学会学術講演会
- Place of Presentation
  福岡市
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 自己免疫性膵炎モデル動物としての自己免疫調節遺伝子(Aire)遺伝子欠損マウス2011
- Author(s)
  永尾幸大、栗崎宏憲、松尾友仁、諸石亜利沙、近藤しおり、安西慶三、勝田仁、永淵正法
- Organizer
  第54回日本糖尿病学会学術講演会
- Place of Presentation
  札幌市
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] C末端12ペプチドアフィニティー精製抗AIRE抗体を用いたWestern blotting法によるAIRE蛋白の発現解析2011
- Author(s)
  松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第81回日本感染症学会西日本地方会学術集会
- Place of Presentation
  北九州市
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 樹状細胞におけるNF-κB経路によるAIRE遺伝子の発現制御の検討2011
- Author(s)
  小田淑恵子、進藤美恵子、松尾友仁、野口由樹、永尾幸大、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第9回1型糖尿病研究会
- Place of Presentation
  神奈川県大磯
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] C末端12ペプチドアフィニティカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRE蛋白の発現解析2011
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第85回日本感染症学会総会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] C末端12ペプチドアフィニテイカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRE蛋白の発現解析2011
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第85回日本感染症学会総会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] アフィニティカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRE蛋白の発現解析2011
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、藤田麻子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第54回日本糖尿病学会学術講演会
- Place of Presentation
  札幌市
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation]2011
- Author(s)
  永尾幸大、栗崎宏憲、松尾友仁、諸石亜利沙、近藤しおり、安西慶三、勝田仁、永淵正法
- Organizer
  第54回日本糖尿病学会学術講演会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 樹状細胞におけるAIRE遺伝子の発現、AIRE遺伝子の表出の検討2011
- Author(s)
  小田淑恵子、松尾友仁、野口由樹、進藤美恵子、永尾幸大、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第85回日本感染症学会総会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 樹状細胞におけるAIRE遺伝子の発現、AIRE遺伝子の表出の検討2011
- Author(s)
  小田淑恵、松尾友仁、野口由樹子、進藤美恵子、永尾幸大、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第85回日本感染症学会総会
- Place of Presentation
  東京
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] Aire欠損マウスへのListeria monocytogenes, Candida albicansmの感染実験2011
- Author(s)
  栗崎宏憲、松尾友仁、小田淑恵、勝田仁、光山正雄、永淵正法
- Organizer
  第81回日本感染症学会西日本地方会学術集会
- Place of Presentation
  北九州市
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 自己免疫調節 (Autoimmune Regulator : AIRE) 遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御機構2010
- Author(s)
  野口由樹子, 松尾友仁, 進藤美恵子, 小田淑恵, 栗崎宏憲, 永淵正法
- Organizer
  83回日本感染症学会総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節遺伝子(AIRE)欠損マウスにおける膵病変の検討2010
- Author(s)
  永尾幸大、松尾友仁、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第48回日本糖尿病学会九州地方会
- Place of Presentation
  別府市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] アフィニテイカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRE蛋白の発現解析2010
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、藤田麻子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第53回日本糖尿病学会学術講演会
- Place of Presentation
  岡山市
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節遺伝子(AIRE)遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御とその意義2010
- Author(s)
  野口由樹子、松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、永淵正法
- Organizer
  第84回日本感染症学会総会
- Place of Presentation
  京都府国際会館
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節遺伝子(AIRE)欠損マウスにおける膵病変の検討2010
- Author(s)
  永尾幸大、松尾友仁、栗崎宏憲, 勝田仁, 永淵正法
- Organizer
  第48回日本糖尿病学会九州地方会
- Place of Presentation
  別府市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節遺伝子(AIRE)遺伝子のAIRE:遺伝子導入細胞とT細胞における発現制御とその意義2010
- Author(s)
  野口由樹子、松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、永淵正法
- Organizer
  第84回日本感染症学会総会
- Place of Presentation
  京都府国際会館
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 自己免疫調節遺伝子(AIRE)遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御とその意義2010
- Author(s)
  野口由樹子、松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、永淵正法
- Organizer
  第84回日本感染症学会総会学術講演会
- Place of Presentation
  京都市
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 自己免疫調節(Autoimmune Regulator : AIRE)遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御機構2010
- Author(s)
  野口由樹子、松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、永淵正法
- Organizer
  83回日本感染症学会総会
- Place of Presentation
  京都市
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] アフィニテイカラム精製抗AIRE抗体を用いたWestern Blotting法によるAIRS蛋白の発現解析2010
- Author(s)
  松尾友仁、進藤美恵子、野口由樹子、永尾幸大、小田淑恵、吉田英子、藤田麻子、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第53回日本糖尿病学会学術講演会
- Place of Presentation
  岡山市
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] 2型糖尿病との関連が示唆されたRS3PE症候群の2症例2009
- Author(s)
  光本富士子, 林武生, 谷合啓明, 豊田一弘, 貝沼茂三郎, 村田昌之, 澤山泰典, 古庄憲浩, 永淵正法, 林純
- Organizer
  第44回日本糖尿病学会九州地方会
- Place of Presentation
  北九州市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] The significance of B cells in the pathogenesis of type 1 diabetes and a possible role of AIRE gene.2009
- Author(s)
  Matsuo T, Noguchi Y, Nagao Y, Shindo M, Kogawa K, Iwakiri R, Akashi 2, Hara T, Kudoh J, Shimizu N, Kurisaki H, Katsuta H, Anzai K, Nagafuchi S.
- Organizer
  The 69^<th> annual meeting of American Diabetes Association Scientific Sessions
- Place of Presentation
  New Orleans.
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] Aire 欠損マウスを用いた Candida albicans の感染防御機構の解析2009
- Author(s)
  栗崎宏憲, 藤本秀士, 光山正雄, 永淵正法
- Organizer
  第83回日本感染症学会総会
- Place of Presentation
  東京都
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] Aire欠損マウスを用いたCandida albicansの感染防御機構の解析2009
- Author(s)
  栗崎宏憲、藤本秀士、光山正雄、永淵正法
- Organizer
  第83回日本感染症学会総会.東京都
- Place of Presentation
  東京都
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節(Autoimmune Regulator : AIRE)遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御機構とその意義2009
- Author(s)
  野口由樹子、松尾友仁、進藤美恵子、小田淑恵、栗崎宏憲、永淵正法
- Organizer
  第77回日本感染症学会西日本地方会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 2型糖尿病との関連が示唆されたRS3PE症候群の2症例2009
- Author(s)
  光本富士子、林武生、谷合啓明、豊田一弘、貝沼茂三郎、村田昌之、澤山泰典、古庄憲浩、永淵正法、林純
- Organizer
  第44回日本糖尿病学会九州地方会
- Place of Presentation
  北九州市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] The significance of B cells in the pathogenesis of type 1 diabetes and a possible role of AIRE gene2009
- Author(s)
  Matsuo T, Noguchi Y, Nagao Y, Shindo M, Kogawa K, Iwakiri R, Akashi 2, Hara T, Kudoh J, Shimizu N, Kurisaki H, Katsuta H, Anzai K, Nagafuchi S.
- Organizer
  The 69^<th> annual meeting of American Diabetes Association Scientific Sessions
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己免疫調節(Autoimmune Regulator:AIRE)遺伝子のAIRE遺伝子導入細胞とT細胞における発現制御機構とその意義2009
- Author(s)
  野口由樹子, 松尾友仁, 進藤美恵子, 小田淑恵, 栗崎宏憲, 永淵正法
- Organizer
  第77回日本感染症学会西日本地方会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-21659230
[Presentation] Aire 欠損マウスを用いた Candida albicans の感染防御機構の解析2009
- Author(s)
  栗崎宏憲, 藤本秀士, 光山正雄, 永淵正法
- Organizer
  第83回日本感染症学会総会
- Place of Presentation
  東京都
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] Aire欠損マウスを用いたCandida albicansの感染防御機構の解析2009
- Author(s)
  栗崎宏憲、藤本秀士、光山正雄、永淵正法
- Organizer
  第83回日本感染症学会総会
- Place of Presentation
  東京都
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] アフィニティカラム精製抗AIREペプチド抗体をもちいた蛋白の発現解析2008
- Author(s)
  松尾友仁, 吉田英子, 進藤美恵子, 栗崎宏憲, 永淵正法ら.
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] Aire欠損マウスを用いた自己免疫性多腺性内分泌不全症・カンジダ症の感染防御障害機構の解析2008
- Author(s)
  栗崎宏憲、松尾友仁、進藤美恵子、小川秀一郎、藤本秀士、光山正雄、永淵正法
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己調節遺伝子AIRE(Autoimmune Regulator)のEBVtransformed B cellにおける発現制御とその意義2008
- Author(s)
  松尾友仁、進藤美恵子、小川秀一郎、栗崎宏憲、永淵正法
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] The significance of Autoimmune Regulator (AIRE) Gene, Responsible for Autoimmune Polyendocrinopathy-Candidiasis-Ectodermaly Dystrophy (APECED), in Both Central and Peripheral Immune System2008
- Author(s)
  Seiho Nagafuchi, Hironori Kurisaki, Tomohito Matuso, Hiroko Hamada, et al.
- Organizer
  The 68^<th> annual meeting of American Diabetes Association Scientific Session
- Place of Presentation
  Convention Center, San Francisco, U. S. A.
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] The significance of Autoimmune Regulator (AIRE) Gene, Responsible for Autoimmune Polyendocrinopathy-Candidiasis Ectodermaly Dystrophy (APECED), in Both Central and Peripheral Immune System2008
- Author(s)
  Seiho Nagafuchi, Hironori Kurisaki, Tomohito Matuso, Hiroko Hamada, Maya Iwanaga, Miki Kawano, Rimiko Koyanagi-Katsuta, Hitoshi Katsuta, Mieko Shindo, Eiko Yoshida, Kazuhiko Kogawa, Toshirou Hara, Mine Harada, Jun Kudoh, Nobuyoshi Shimizu
- Organizer
  The 68^<th> annual meeting of American Diabetes Association Scientific Sessions
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] アフィニティカラム精製抗AIREペプチド抗体をもちいた蛋白の発現解析。2008
- Author(s)
  松尾友仁、吉田英子、進藤美恵子、濱田寛子、河野弥季、小川秀一郎、内野由梨、栗崎宏憲、永淵正法
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] アフィニティカラム精製抗AIREペプチド抗体をもちいた蛋白の発現解析2008
- Author(s)
  松尾友仁, 吉田英子, 進藤美恵子, 濱田寛子, 河野弥季, 小川秀一郎, 内野由梨, 栗崎宏憲, 永淵正法
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己調節遺伝子AIRE(Autoimmune Regulator)のEBV transformed Bcellにおける発現制御とその意義2008
- Author(s)
  松尾友仁, 進藤美恵子, 小川秀一郎, 栗崎宏憲, 永淵正法
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市県民文化会館
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] Aire欠損マウスを用いた自己免疫性多腺性内分泌不全症・カンジダ症の感染防御障害機構の解析2008
- Author(s)
  栗崎宏憲, 松尾友仁, 進藤美恵子, 光山正雄, 永淵正法ら
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市県民文化会館
- Year and Date
  2008-04-18
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] The significance of Autoimmune Regulator (AIRE) Gene, Responsible for Autoimmune Polyendocrinopathy-Candidiasis Ectodermaly Dystrophy (APECED ), in Both Central and Peripheral Immune System.2008
- Author(s)
  Seiho Nagafuchi, Hironori Kurisaki, Tomohito Matuso, Hiroko Hamada, Maya Iwanaga, Miki Kawano, Rimiko Koyanagi-Katsuta, Hitoshi Kat suta, Mieko Shindo, Eiko Yoshida, Kazuhiko Kogawa, Toshirou Hara, Mine Harada, Jun Kudoh, Nobuyoshi Shimizu
- Organizer
  The 68^<th> annual meeting of American Diabetes Association Scientific Sessions
- Place of Presentation
  San Francisco.
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] Aire 欠損マウスを用いた自己免疫性多腺性内分泌不全症・カンジダ症の感染防御障害機構の解析2008
- Author(s)
  栗崎宏憲, 松尾友仁, 進藤美恵子, 小川秀一郎, 藤本秀士, 光山正雄, 永淵正法
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己調節遺伝子AIRE (Autoimmune Regulator) のEBV transformed B cell における発現制御とその意義2008
- Author(s)
  松尾友仁, 進藤美恵子, 小川秀一郎, 栗崎宏憲, 永淵正法
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己調節遺伝子AIRE(Autoimmune Regulator)の末梢T細胞系列における発現制御とその機能2007
- Author(s)
  松尾友仁、進藤美恵子、松尾友仁、小川秀一郎、栗崎宏憲、原田実根、永淵正法
- Organizer
  第81回日本感染症学会総会
- Place of Presentation
  京都市
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] ウイルス誘発糖尿病におけるアポトーシス関連分子の意義2007
- Author(s)
  小川秀一郎、永淵正法
- Organizer
  第48回日本臨床ウイルス学会
- Place of Presentation
  富山市
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-18659270
[Presentation] 末梢血免疫担当細胞における自己免疫調節(Autoimmune regulator:AIRE)遺伝子の発現制御機構とその機能2007
- Author(s)
  松尾友仁、進藤美恵子、小川秀一郎、栗崎宏憲、永淵正法
- Organizer
  第77回日本感染症学会西日本地方会学術集会
- Place of Presentation
  佐賀市
- Year and Date
  2007-10-13
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 自己調節遺伝子AIRE (Autoimmune Regulator) の末梢T細胞系列における発現制御とその機能2007
- Author(s)
  松尾友仁, 進藤美恵子, 松尾友仁, 小川秀一郎, 栗崎宏憲, 原田実根, 永淵正法
- Organizer
  第81回日本感染症学会総会
- Place of Presentation
  京都市
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 再発性HSV感染症を併発した1型糖尿病を有するAPECED患者の1例2007
- Author(s)
  永淵正法、進藤美恵子、吉田英子、原田実根、小河一彦、安西慶三、赤司朋之
- Organizer
  第45回日本糖尿病学会九州地方会
- Place of Presentation
  宮崎市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 単一の単純ヘルペスウイルス株により初感染から再発性口内炎を繰り返したL29P,IVS9-1G>CのAIRE遺伝子変異を有する自己免疫性多腺性内分泌不全症・カンジダ症・外胚葉性ジストロフィー(APECED)の一例2007
- Author(s)
  永淵正法、小川秀一郎
- Organizer
  第48回日本臨床ウイルス学会
- Place of Presentation
  富山市
- Year and Date
  2007-06-03
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] 末梢血免疫担当細胞における自己免疫調節(Autoimmune regulator : AIRE)遺伝子の発現制御機構とその機能2007
- Author(s)
  松尾友仁、進藤美恵子、小川秀一郎、栗崎宏憲、永淵正法
- Organizer
  第77回日本感染症学会西日本地方会学術集会
- Place of Presentation
  佐賀市
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] マウス脳心筋炎ウイルス(EMCV)誘発糖尿病におけるT,B細胞、マクロファージの役割2007
- Author(s)
  小川秀一郎、松尾友仁、進藤美恵子、原田実根、栗崎宏憲、永淵正法
- Organizer
  第81回日本感染症学会総会
- Place of Presentation
  京都市
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-18659270
[Presentation] 自己調節遺伝子AIRE(Autoimmune Regulator)の末稍細胞系列における発現制御とその機能2007
- Author(s)
  松尾友仁、進藤美恵子、松尾友仁、小川秀一郎、栗崎宏憲、原田実根、永淵正法
- Organizer
  第81回日本感染症学会総会
- Place of Presentation
  京都市
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-19209037
[Presentation] ヒト胸腺および末梢血におけるAIRE遺伝子・蛋白の発現とその制御メカニズム
- Author(s)
  森田賢史、栗崎宏憲、勝田仁、永淵正法
- Organizer
  第54回日本臨床ウイルス学会
- Place of Presentation
  倉敷市
- Data Source
  KAKENHI-PROJECT-25670461

1. KURISAKI Hironori (70403962)

# of Collaborated Projects: 3 results

# of Collaborated Products: 56 results
2. SHIMADA Kazuya (90311844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KATSUTA HITOSHI (50333240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. NAKANO Shuji (40164248)

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5. NAKAMURA Minoru (40217906)

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# of Collaborated Products: 0 results
6. MITSUYAMA Masao (10117260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. KITAMURA Daisuki (70204914)

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8. OTSUKA Takeshi (50213773)

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9. WATANABE Takeshi (40028684)

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10. SHIMIZU Nobuyoshi (50162706)

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11. TAKAYANAGI Atsushi (80245464)

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12. MINOSHIMA Shinsei (90181966)

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13. KUDOH Jun (80178003)

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14. SAKAGUCHI Shimon (30280770)

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15. KONO Tomohiro (80153485)

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16. ITO Mamoru (00176364)

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17. Kobayashi Tetsuro (30113442)

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18. 陳嘉竝 (10296725)

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19. 浅川修一 (30231872)

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20. 梅村創 (90136432)

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21. 雨宮三千代 (00288101)

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22. 會田薫 (50184015)

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23. 高橋宏和 (20607783)

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24. 安西慶三 (60258556)

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25. AKASHI Tomoyuki

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26. 一瀬一郎

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27. 中山政明

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28. 西村康治

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29. 吉開康信

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30. 東元健

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Nagafuchi Seiho 永淵 正法

NAGAFUCHI Seiho 永淵 正法

永渕 正法 ナガフチ セイホウ

Research Projects

Research Products

Co-Researchers

The significance and the mechanisms of virus-induced diabetes susceptibility genesPrincipal Investigator

Principal Investigator

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Review Section

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Epigenetic regulation of development and maturation processes in pancreatic beta cells

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Physiological and pathophysilogical roles of acinar-like cell cluster touching Langerhans islet with thin interstitial surrounding (ATLANTIS) on regeneration and maintenance of beta cell.

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Clinical significance of anti-disulfide isomerase based on the AIRE researchPrincipal Investigator

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Regeneration of pancreatic beta-cell from pancreatic SP cell

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Analysis of regulatory mechanisms of type 1 diabetes by B cells, based on the AIRE researchPrincipal Investigator

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The mechanisms for the deterioration of infection control in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)Principal Investigator

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ウィルス糖尿病高感受性マウスの開発Principal Investigator

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Pathogenesis of virus induced diabetesPrincipal Investigator

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Practical use of cloning technology for NOD and dy disease model mice production

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Roles of the Autoimmune Regulator (AIRE) Gene in Immune Response

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ANALYSIS OF SUPPRESSION OF AUTOIMMUNE DIABETES IN B-CELL DEFICIENT NOD MICE.Principal Investigator

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Functional analysis of infiltrating lymphocytes in islets of NODmice by using gene targeting.Principal Investigator

Principal Investigator

Nagafuchi Seiho 永淵正法

NAGAFUCHI Seiho 永淵正法

永渕正法ナガフチセイホウ