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KONDO Takahito  近藤 宇史

ORCIDConnect your ORCID iD *help
Researcher Number 00158908
Affiliation (based on the past Project Information) *help 2002 – 2005: Course of Medical and Dental Science, Graduate School of Biomedical Science, professor, 大学院・医歯薬学総合研究科, 教授
1993 – 2002: 長崎大学, 医学部, 教授
1988 – 1991: 北海道大学, 医学部, 講師
1986: Hokkaido University School of Medicine, Instructor, 医学部, 助手
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Hematology / 内分泌・代謝学 / General medical chemistry / Biological pharmacy
Except Principal Investigator
Laboratory animal science / Pathological medical chemistry / 内分泌・代謝学 / Metabolomics / Pathological medical chemistry … More / Risk sciences of radiation/Chemicals / Circulatory organs internal medicine / Hematology / Laboratory medicine / Respiratory organ internal medicine Less
Keywords
Principal Investigator
グルタチオン / ATPase / 膜輸送 / 赤血球 / glutathione / γ-グルタミルシステイン合成酵素 / Glutathione / Erythrocyte / GLUTATHIONE S-CONJUGATE / GLUTATHIONE … More / MEMBRANE TRANSPORT / ERYTHROYCTES / ATP use / グルタチオンS-抱合体 / Primary aldosteronism / Carbonic anhydrase I / 原発性アルドステロン症 / カーボニックアンヒドラーゼI / hammerhead ribozyme / insulin / γ-glutamylcysteine synthetase / pancreatic β-cells / ハンマーヘッドリボザイム / インスリン / 膵β細胞 / TNF-alpha / NF-_kB / redox / beta-Cell / IDDM / ribozyme / gamma-glutamylcysteine / サイトカイン / β-GCS / マウスβ細胞 / NF-κB / TNF-α / NF-kB / レドックス / β-細胞 / 糖尿病 / リボザイム / γ-グルタミルシステイン / Transport / Antioxidant / Drag Resistance / Citotoxicity / gamma-Glutamylcystein Synthetase / 酸化的ストレス / アンチオキシダント / 薬剤耐性 / 細胞障害 / Glutathione S-Conjugate / Membrane Transport / グルタチオン抱合体 / グルタチオンSー抱合体 … More
Except Principal Investigator
γ-GCS / LCMV / apoptosis / グルタチオン / アポトーシス / glutathione S-transferase π / 奇形 / アンチオキシダント / nucleus / anti-cancer drug resistance / exocyclic DNA adducts / oxidative stress / p53 / Akt / GST / doxorubicin / drug resistance / cancer / cisplatin / nuclear translocation / Recombinant antigen / 診断用組換え抗原 / リンパ球性脈絡髄膜炎ウイルス / 2 / ERK1 / activator protein-1 / ROR / RZR / VEGF / 8-OHdG / CD95 / ATL / 糖尿病 / scavenger system / antioxidant system / hyperglycemia / free radical / glutathione / embryo culture / フリーラジカル / スカヴェンジャーシステム / 胎仔培養 / オキシダント / Bcl-2 / Bax / mitochondria / mitochondria import signal / nuclear localization signal / glutathione S-transferasen / glutathione S-transferaseπ / doxoruvicin / deug resistance / molecular chaperone / cardiomyocyte / calreticulin / 分子シャペロン / 心筋細胞 / カルレティキュリン / 遺伝子組換え抗原 / LCMウイルス / 血管内皮増殖因子 / メラトニン / diabetic pregnancy / malformation / organogenesis / bcl-2 / bax / embryo / 20%O_2 / 胎芽 / グルタチオン(GSH) / スカヴェンジャー / 糖尿病ラット / 神経管閉鎖不全 / GLUTATHIONE / ANTIOXIDANT / OXIDANT / FAS / APOPTOSIS / ceramide / GSH / Fas / Apoptosis / gamma-glutamyl transpeptidase / heparin binding EGF-like growth factor / apolipoprotein E / site-directed mutagenesis / glycation / vascular smooth muscle / diabetes / アポプロテインE / 糖転移酵素 / 糖タンパク質 / γ-glutamyl transpeptidase / 糖鎖遺伝子 / r-グルタミルトランスペプチダーゼ / γ-グルタミルトランスペプチダーゼ / ヘパリン結合性EGF様増殖因子 / アポリポプロテインE / 部位特異的変異 / 糖化反応 / 血管平滑筋 / 胎仔 / 高血糖 / 妊娠糖尿病ラット / Sepsis / Manganese superoxide dismutase / Adult respiratory distress syndrome (ARDS) / モノクローナル抗体 / ARDS / Mn-SOD / 酵素免疫測定法(ELISA) / 敗血症 / Mn-スーパーオキシドディスムターゼ(Mn-SOD) / 成人呼吸切迫症候群(ARDS) / Elastin / Antioxidant / Oxidant / Neutrophil elastase / Alveolar macrophage / Bronchoalveolar lavage / Computed tomography / Emphysema / α1-アンチトリプシン / アルファ1-アンチトリプシン / 胸部CT検査 / EDP / 中高年者 / 喫煙 / エラスチン / 好中球エラスターゼ / 肺胞マクロファージ / 気管支肺胞洗浄 / 胸部CT / 肺気腫 / embryo(胎芽) / 軟骨細胞 / RT-PCR / 遺伝子発現 / 3′RACE法 / 染色体転座 / ポジショナルクローニング / 遺伝子 / 多発性外骨腫 Less
  • Research Projects

    (22 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (32 People)
  •  Molecular mechanism of intracellular localization of glutathione S-transferase π

    • Principal Investigator
      GOTO Shinji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Effect of nuclear glutathione on DNA damage by irradiation

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Nagasaki University
  •  Basic Research of Novel Molecular Target on Cancer Chemotherapy

    • Principal Investigator
      GOTO Shinji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Producing and Certification of Recombinant Antigen with LCMV Isolated in Japan for Diagnosis of LCMV Infection in Mice.

    • Principal Investigator
      OHSAWA Kazutaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Nagasaki University
  •  Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cadiomyoblast H9c2 cells

    • Principal Investigator
      TODA Genji
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagasaki University
  •  糖尿病の奇形発生におけるアポトーシスの誘導機構と分子メカニズムの解明

    • Principal Investigator
      AKAZAWA Shoichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Nagasaki University
  •  The effect of melatonin on the cell proliferation

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Producing of Recombinant Antigen with LCMV Isolated in Japan and Diagnosis of LCMV Infection in Mice

    • Principal Investigator
      OHSAWA Kazutaka
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Nagasaki University
  •  Regulation of pancreatic β-cell function by glutathionePrincipal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Role of apoptosis and the expression of bax and bcl-2 on diabetic embryopathy

    • Principal Investigator
      AKAZAWA Shoichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Nagasaki University
  •  Antioxidant system and apoptosis in diabetes-induced embryonic malformation.

    • Principal Investigator
      AKAZAWA Shoichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Nagasaki University
  •  Significance of sugar moiery of recombinant glycoproteins

    • Principal Investigator
      TANIGUCHI Naoyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  Study on the development of therapy for insulin-dependent diabetes melitus addressing the regulation of pancreatic beta-cells death.Principal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Nagasaki University
  •  THE INVOLVEMENT OF OXIDANT AND ANTIOXIDANT SYSTEM IN FAS-MEDIATED APOPTOSIS OF ATL CELLS.

    • Principal Investigator
      YAMADA Yasuaki
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagasaki University
  •  多発性外骨腫(がん抑制遺伝子のポジショナルクローニングと発がん機構

    • Principal Investigator
      新川 詔夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagasaki University
  •  Development and practical use of predictive methods of adult respiratory distress syndrome in patients with sepsis

    • Principal Investigator
      TANIGUCHI Naoyuki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Osaka University
  •  Augmentation of Transport for Cisplatin-glutathione Adduct in Cisplatinresistant Cancer CellsPrincipal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Nagasaki University
  •  Glutathione-dependent antioxidant system in diabetes-induced embryopathy.

    • Principal Investigator
      AKAZAWA Shoichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Nagasaki University
  •  ROLE OF ALVEOLAR MACROPHAGES IN PATHOGENESIS OF PULMONARY EMPHYSEMA

    • Principal Investigator
      KAWAKAMI Yoshikazu
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Analysis of transport system for glutathione and glutathione conjugates as a factor of cell defense and drug metabolism.Principal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  A NOVEL ATPase OF ERYTHROYCTE MEMBRANES IN RELATION TO TRANSPORT OF GLUTATHIONE AND GLUTATHIONE CONJUGATES.Principal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Clinical and Basic Study on Human Erythrocyte Carbonic Anhydrase I-Presence of a Mixed Disulfide with Glutathione.Principal Investigator

    • Principal Investigator
      KONDO Takahito
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hokkaido University

All 2005 2004

All Journal Article

  • [Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005

    • Author(s)
      Soh, Y., Goto, S., Kitajima, M., Moriyama, S., Kotera, K., Nakayama, T., Nakajima, H., Kondo, T., Ishimaru, T.
    • Journal Title

      Clinical Oncology, 17(4)

      Pages: 264-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuclear glutathione S-transferase p prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004

    • Author(s)
      Kamada, K., Goto, S., Okunaga, T., Ihara, Y., Tsuji, K., Kawai, Y., Uchida, K., Osawa, T., Matsuo, T., Nagata, I., Kondo, T.
    • Journal Title

      Free Radical.Biol.Med., 37(11)

      Pages: 1875-1884

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • 1.  IHARA Yoshito (70263241)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 2.  AKAZAWA Shoichi (10145261)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  GOTO Shinzi (50186889)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 4.  KATNAMINE Shigeru (40161062)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KOJI Takehito (30170179)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TANIGUCHI Naoyuki (90002188)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMASHITA Shunichi (30200679)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  URATA Yoshishige (30185087)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  OHSAWA Kazutaka (90244756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SATO Hiroshi (50072947)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  KAWAKAMI Yoshikazu (10001877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NISHIMURA Masaharu (00208224)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MIYAMOTO Kenji (50190814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SUZUKI Keiichiro (70221322)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  FUJII Junichi (00222258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TOMONAGA Masao (40100854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YAMADA Yasuaki (60145232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KIJIMA Hiroshi (90204859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TODA Genji (00253659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YANO Katsusuke (50039864)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  新川 詔夫 (00111170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  陣野 吉廣 (20179097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  長瀧 重信 (70010311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TSUKADA Yutaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  CHOUVAEV Vladimir V
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  YAMAMOTO Hirotaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  DENNIS James W
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  DEUTSCH Harold F
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  ANDERSON Mary E
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  SIEST Gerard
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  SCHACHTER Harry
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  近藤 英明
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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