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KAWANO Seiko  川野 誠子

ORCIDConnect your ORCID iD *help
Researcher Number 00177718
Other IDs
Affiliation (based on the past Project Information) *help 2010: Tokyo Medical and Dental University, 人間健康学部, 教授
2009: Komazawa Women's University, 人間健康学部・健康栄養学科, 教授
2008: Tokyo Medical and Dental University, 難治疾患研究所, 准教授
2001 – 2005: 東京医科歯科大学, 難治疾患研究所, 助教授
2004: 国立大学法人東京医科歯科大学, 難治疾患研究所, 助教授
2003 – 2004: 東京医科歯科大学, 医学部, 助教授
1993 – 1998: 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field
Principal Investigator
General physiology / General physiology / Thoracic surgery
Except Principal Investigator
Circulatory organs internal medicine / 医薬分子機能学
Keywords
Principal Investigator
クロライドチャネル / 心筋細胞 / 筋小胞体 / イオンチャネル / ES細胞 / リアノジン受容体 / 幹細胞 / カルシュウム / Signal Transduction / Cardiac Myocyte … More / Ca^<2+> / Ryanodine Receptor / Sarcoplasmic Reticulum / 分化 / 分化誘導 / 胚性幹細胞 / Na-Ca交換機構 / Na-Kポンプ / Caチャネル / CFTR / Heart Failure / Remodeling / Lethal Arrhtymia / Cardiomyopathic hamster / K Channel / Ca Channel / HERG Channel / Arrhythmia / Ion Channel / 圧負荷 / ペースメーカーチャネル / 容積感受性クロールチャネル / 心不全 / 心肥大 / HERG電流密度減少 / チャネル蛋白発現 / 蛋白チロシン燐酸化 / L型Caチャネル / 一過性外向きKチャネル / チャネルリモデリング / チャネル輸送 / Long QT症候群 / KCNQ1 / HERG / 遺伝子異常 / リモデリング / 致死性不整脈 / 心筋症ハムスター / Kチャネル / HERGチャネル / 不整脈 / Na^+・K^+ pump / Na^+ Ca^<2+> exchanger / Ca^<2+> signaling pathway / Ryanodine receptor / IP3 receptor / excitation-contraction coupling / cardiomyocyte / ES cell / 心筋 / 容量性カルシュウム流入 / カルシュウムチャネル / Na-K pump / Na-Ca exchanger / plasma membrane Ca pump / Caシグナル伝達 / Caシグナル伝達経路 / IP3受容体 / 興奮-収縮連関 / Cl-channel / カルモジュリン / Mg^<2+> / 細胞内Ca^<2+> / C1-channel / ClC family / Ca / トランスポーター / クロライドチンネル / 間葉系幹細胞 / 脂肪細胞 / Calcium / T-type / L-type / 心筋分化 / アデニンヌクレオチド / 電気生理学 / 人工脂質膜 / ATP通過 / パッチクランプ / クロライド電流 / イオン透過性 … More
Except Principal Investigator
K ATPase / Na / cardiomyocvtes / Ca exchanger / ion channels / stem cells / Ca電流 / IP_3レセプター / カルシウム / 胚性幹細胞 / 心筋細胞 / Ca交換系 / KATPase / イオンチャネル / 幹細胞 / drug design / new compounds / structural biology / drug binding site / photoaffinity labeling / Calcium antagonist / 薬理活性 / 抗ペプチド抗体 / 精密合成化学 / 心筋Caチャンネル / 光アフィニティラベリング / ドラッグデザイン / 新規化合物 / 構造生物学 / 薬物結合部位 / 光アフィニティ ラベリング / Ca拮抗薬 / Ryanodine receptor channel / Ca^<2+> -activated Cl^- -channel / HERG K^+ channel / K^+ channel / ATP-sensitive / L-type Ca^<2+> channel / protein phosphorylation / Ca活性化Clチャネル / cGMP / α受容体 / リン酸化部位 / Caチャネル / Ca放出リヤノジン受容体 / L型Caチャネル / HERG Kチャネル / ATP感受性Kチャネル / 蛋白リン酸化 / Cl-channel / artificial lipid bilayr / sarcoplasmic reticulum / Ryanodine receptor Ca^<2+> release channel / 隣酸化 / 小胞体 / リャノジン受容体チャネル / Cl-チャネル / 人工脂質膜 / リアノジン受容体チャネル / 筋小胞体 / Ca^<2+>放出 / HCN4 / cibenzoline / maturation / glycosilation / c-Src / tyrosine kinase / trafficking defect / HERG Less
  • Research Projects

    (14 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (15 People)
  •  Investigation of the physiological functions of anion channels during the differentiation in stem cells.Principal Investigator

    • Principal Investigator
      KAWANO Seiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical and Dental University
  •  HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用

    • Principal Investigator
      HIRANO Yuji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  間葉系幹細胞から心筋細胞への分化過程に於けるイオンチャネルの機能発現機序の検討Principal Investigator

    • Principal Investigator
      川野 誠子
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical and Dental University
  •  Electrophysiological properties of cardiomyocytes differentiated from mouse embrionic stem cells

    • Principal Investigator
      HIRAYAMA Yoshiyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nippon Medical School
  •  The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator

    • Principal Investigator
      KAWANO Seiko, 平岡 昌和
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  The functional development of excitation-contraction coupling during cardiomyogenesis in mouse embryonic stem cellsPrincipal Investigator

    • Principal Investigator
      KAWANO Seiko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical & Dental University
  •  小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

    • Principal Investigator
      川野 誠子
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

    • Principal Investigator
      川野 誠子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels

    • Principal Investigator
      NAKAYAMA Hitoshi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

    • Principal Investigator
      川野 誠子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  心筋に於けるCa2+活性化クロライドチャネルの機能と細胞内調節機構の解明Principal Investigator

    • Principal Investigator
      川野 誠子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical and Dental University
  •  Modulatory mechanisms of cardiac ion channels.

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
  •  Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University, Medical Research Institute
  •  Intracellular regulation of Ca^<2+> release from cardiac sarcoplasmic reticulum.Principal Investigator

    • Principal Investigator
      KAWANO Seiko
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical and Dental University, Medical Research Institute.

All 2011 2010 2005 2004 2003 2002 Other

All Journal Article Presentation

  • [Journal Article] Synergic effects of β-estradiol and erythromycin on hERG currents.2011

    • Author(s)
      Fumiaki Ando, Akinori Kuruma Seiko Kawano
    • Journal Title

      Journal of Membrane Biology May 241(1)

      Pages: 31-8

    • Data Source
      KAKENHI-PROJECT-20590206
  • [Journal Article] Synergic effects of β-estradiol and crythromycin on hERG currents2011

    • Author(s)
      F.Ando, A.Kuruma, S.Kawano
    • Journal Title

      Journal of Membrane Biology

      Volume: 241 Pages: 31-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590206
  • [Journal Article] Na^+/K^+ ATPase and its functional coupling with Na^+/Ca^<2+> exchanger in mouse embryonic stem cells during differentiation into cardiomyocytes2005

    • Author(s)
      K.Otsu, A.Kuruma, E.Yanagida, S.Shoji, T.Inoue, Y.Hirayama, H.Uematsu, Y.Hara, S.Kawano.
    • Journal Title

      Cell Calcium

      Pages: 137-151

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Na^+/K^+ ATPase and its Functional Coupling with Na^+/Ca^<2+> in Mouse Embryonic Stem Cells during Differentiation into Cardiomyocytes2005

    • Author(s)
      K.Otsu, A.Kuruma, H.Uematsu, S.Kawano, et al.
    • Journal Title

      Cell Calcium 37

      Pages: 137-151

    • Data Source
      KAKENHI-PROJECT-15659049
  • [Journal Article] Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.2004

    • Author(s)
      E.Yanagida, S.Shoji, Y.Hirayama, F.Yoshikawa, K.Otsu, H.Uematsu, M.Hiraoka, T.Furuichi, S.Kawano
    • Journal Title

      Cell Calcium 36

      Pages: 135-146

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004

    • Author(s)
      T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
    • Journal Title

      J.Mol.Cell.Cardiol. 37

      Pages: 1205-1211

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
    • Journal Title

      J.Mol.Cell.Cardiol 37

      Pages: 1205-1211

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      T.Sasano, S.Kawano, M.Hiraoka et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 37

      Pages: 1205-1211

    • Data Source
      KAKENHI-PROJECT-15659049
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M.
    • Journal Title

      J.Mol.Cell.Cardiol. 37

      Pages: 1205-1211

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004

    • Author(s)
      Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Data Source
      KAKENHI-PROJECT-15659049
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004

    • Author(s)
      Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004

    • Author(s)
      Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004

    • Author(s)
      Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004

    • Author(s)
      Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Ca2+ signaling pathways in mouse embryonic stem cells2004

    • Author(s)
      Yanagida E, Otsu Y, Hirayama Y, Shoji H, Uematsu M, Hiraoka M, Kawano S.
    • Journal Title

      Cell Calcium 36

      Pages: 135-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590775
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004

    • Author(s)
      Aizawa Y, Ueda K,.., Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M.
    • Journal Title

      FEBS Lett. 574

      Pages: 145-150

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Block of HERG current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004

    • Author(s)
      Hiramatsu M, Wu L-M, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004

    • Author(s)
      Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka et al.
    • Journal Title

      FEBS letter 574

      Pages: 145-150

    • Data Source
      KAKENHI-PROJECT-15659049
  • [Journal Article] Functional expression of Ca signaling pathways in mouse embryonic stem cells2004

    • Author(s)
      E.Yanagida, S.Shoji, M.Hiraoka, T.Furuichi, S.Kawano
    • Journal Title

      Cell Calcium 36

      Pages: 135-146

    • Data Source
      KAKENHI-PROJECT-15659049
  • [Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003

    • Author(s)
      Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      J Cardiovasc Pharmacol 42

      Pages: 410-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003

    • Author(s)
      Kocic I, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      Basic Res Cardiol 98

      Pages: 367-379

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003

    • Author(s)
      Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      J Cardiovasc Pharmacol 42

      Pages: 410-418

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Moving dipole analysis of normal and abnormal ventricular activation by magnetocardiography.2002

    • Author(s)
      Hiyoshi Y, Sakurada H, Izumida N, Kawano S, Sawanobori T, Hiraoka M.
    • Journal Title

      J Electrocardiol 35

      Pages: 105-114

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Presentation] BLOCKING KINETICS OF CFTR CHANNEL BY AROMATIC CARBOXYLATE POSITIONAL ISOMERS CHARACTERISED USING A NOVEL AMPLITUDE DISTRIBUTION ANALYSIS METHOD2010

    • Author(s)
      Ying-Chun Yu, Yoshiro Sohma, Seiko Kawano, et al
    • Organizer
      54^<th> Biophysical Society(USA)
    • Place of Presentation
      アメリカ合衆国、サンスランシスコ、カリフォルニア
    • Year and Date
      2010-02-22
    • Data Source
      KAKENHI-PROJECT-20590206
  • [Presentation] Blocking kinetics of cftr channel by aromatic carboxylate positional isomers characterised using a novel amplitude distribution analysis method.

    • Author(s)
      Ying-Chun Yu、Yoshiro Sohma, Seiko Kawano, et al
    • Organizer
      in 54^<th> Biophysical Society (USA)
    • Place of Presentation
      at San Francisco
    • Data Source
      KAKENHI-PROJECT-20590206
  • 1.  HIRAOKA Masayasu (80014281)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 2.  HIRANO Yuji (00181181)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 3.  KUNIYASU Akihiko (90241348)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  NAKAYAMA Hitoshi (70088863)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  ICHINOSE Shizuko (60014156)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  ISHIZUKA Tadao (60176203)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YAMAGATA Kazuo (10299323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HIRAYAMA Yoshiyuki (50322516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  吉川 文生 (70342871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  豊島 近 (70172210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  CORONAD Roberts
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HARTZELL Criss
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  FOZZARD Harry A
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NABATA Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  CORONADO Rob
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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