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Kubohara Yuzuru  久保原 禅

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… Alternative Names

KUBOHARA Yuzuru  久保原 禅

久保原 禅  クボハラ ユズル

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Researcher Number 00221937
Other IDs
Affiliation (Current) 2025: 順天堂大学, スポーツ健康科学部, 客員教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 順天堂大学, 大学院スポーツ健康科学研究科, 教授
2015 – 2020: 順天堂大学, スポーツ健康科学研究科, 教授
2015: 順天堂大学, スポーツ健康科学部, 教授
2007 – 2014: Gunma University, 生体調節研究所, 准教授
2001 – 2006: 群馬大学, 生体調節研究所, 助教授 … More
2004: 群馬大学, 生体調整研究所, 助教授
1999: 群馬大, 生体調節研究所, 助手
1997 – 1998: 群馬大学, 生体調節研究所, 助手
1994 – 1995: 群馬大学, 生体調節研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Biological pharmacy / 内分泌・代謝学 / Basic Section 38030:Applied biochemistry-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Pharmacology in pharmacy / Metabolomics / Cell biology
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Laboratory animal science … More / Applied health science / Mathematical Sciences in Search of New Cooperation / Medical pharmacy / Functional biochemistry Less
Keywords
Principal Investigator
DIF / 糖尿病 / 細胞性粘菌 / がん / Dictyostelium / PDE1 / トリパノソーマ / 免疫 / calcium / 抗菌剤 … More / 抗がん剤 / 創薬 / K562 / Erk / 抗腫瘍因子 / DIF-1 / 走化性運動 / ミトコンドリア / 糖代謝 / 肥満 / 分化誘導因子 / anti-tumor agent / Dictyostelium discoideum / D. discoideum / 天然物化学 / マラリア / 抗菌薬 / 細胞分化 / 転移阻害剤 / Zinc / 亜鉛 / Cancer / Anti-tumor drug / 癌 / activin / pancreas / diabetes / differentiation / βcell / pancreatic stem cell / insulin / regeneration medicine / 幹細胞 / 分化誘導 / 膵β細胞 / 膵幹細胞 / インスリン / 再生医学 / 低分子化合物 / 抗腫瘍剤 / anti-tamor agent / Dictyostalium / PKB / Akt / P13-kinase / leukemia / HL-60 / AR42J / differentiation-inducing factor / Differentiation / Differentiation-inducing factor … More
Except Principal Investigator
細胞性粘菌 / 一酸化窒素 / ニトロ化 / 酸化ストレス / DIF-1 / 新規免疫制御剤 / DIF誘導体 / IL-2 / サイトカイン / 合成化合物 / セクリトーム解析 / 6-ニトロトリプトファン / アトピー性皮膚炎 / アレルギー / 運動 / 微生物モニタリング / 日和見病原体 / 病原因子 / 細菌分類 / 全ゲノム / 食作用 / Esi / Cdi / Rodentibacter spp. / R. heylii / R. pneumotropicus / RTX毒素 / ドラフトゲノム / 肺パスツレラ / DIF / 炎症 / 肥満 / 高血糖 / 糖尿病 / 3-ニトロチロシン / 6-ニトロトリプトファン / 細胞運動 / 白血球遊走 / 走化性方程式 / Fokker-Planck方程式 / CFD解析 / PIV実験 / Navier-Stokes方程式 / Keller-Segel系 / Langevin方程式 / 流体型移流拡散方程式 / 拡散性 / 走化性 / Dictyopyrones / pharmacological specific target / growth inhibitory activity / leukemia cells / DIF-1 like factors / differentiation-inducing factor / cellular slime mold / ハロゲン化化合物 / キノコ / 4-methyl-5-n-propylbenzene-1,3-diol / Dictiostelium mucoroides / 増殖抑制 / DIF様因子 / dictyopyrones / 薬理学的ターゲット / 増殖阻害活性 / 白血病細胞 / DIF-1様因子 / 分化誘導因子 / Gab-1 / Src / チロシンリン酸化 / カドヘリン / 局在化 / 細胞間接着 / HGF / 増殖因子受容体 Less
  • Research Projects

    (19 results)
  • Research Products

    (179 results)
  • Co-Researchers

    (24 People)
  •  細胞性粘菌由来化合物をリードとした新規肥満治療薬・糖尿病治療薬の開発Principal Investigator

    • Principal Investigator
      久保原 禅
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38030:Applied biochemistry-related
    • Research Institution
      Juntendo University
  •  免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索

    • Principal Investigator
      高橋 克典
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Gunma Paz University
  •  Effects of moderate exercise on type I allergy

    • Principal Investigator
      IIZUMI Kyoichi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Shibata Gakuen University
  •  Drug development using biologically active substances derived from D. discoideum as seedsPrincipal Investigator

    • Principal Investigator
      Kubohara Yuzuru
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      Juntendo University
  •  Search for anti-diabetic agents based on protein nitration

    • Principal Investigator
      IIZUMI Kyoichi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied health science
    • Research Institution
      Tohoku Womens College
      Juntendo University
  •  Reclassification of [Pasteurella] pneumotropica and detection of virulence determinants.

    • Principal Investigator
      Sasaki Hiraku
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Juntendo University
  •  Research on pharmacologically active molecule DIF found in the cellular slime mold Dictyostelium discoieumPrincipal Investigator

    • Principal Investigator
      Kubohara Yuzuru
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Juntendo University
  •  Mathematical modelling of diffusion-drift system of double chemotaxis type coupled with fluid

    • Principal Investigator
      Sugiyama Yoshie
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Mathematical Sciences in Search of New Cooperation
    • Research Institution
      Osaka University
      Kyushu University
  •  Study on the bio-active molecule, DIF, found in the cellular slime mold Dictyostelium discoideumPrincipal Investigator

    • Principal Investigator
      Kubohara Yuzuru
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Juntendo University
      Gunma University
  •  Study on the bio-active molecule, DIF, found in the soil micro-organism Dictyostelium discoideumPrincipal Investigator

    • Principal Investigator
      KUBOHARA Yuzuru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Gunma University
  •  Analysis of the mechanisms of the actions of DIF, a bio-active compound isolated from a soil micro-organism, and development of effective DIF derivativesPrincipal Investigator

    • Principal Investigator
      KUBOHARA Yuzuru
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Gunma University
  •  Analysis of the mechanisms of the actions of DIF-1 and its derivatives, anti-tumor agents isolated from DictyosteliumPrincipal Investigator

    • Principal Investigator
      KUBOHARA Yuzuru
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Gunma University
  •  Search for novel anti-tumor drugs and study on the action mechanism

    • Principal Investigator
      HOSAKA Kohei
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Gunma University
  •  Analysis of the actions and the action mechanism of DIF, an anti-tumor agent isolated from a soil microorganismPrincipal Investigator

    • Principal Investigator
      KUBOHARA Yuzuru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Gunma University
  •  増殖因子受容体の細胞接着部位特異的な局在化の分子機構

    • Principal Investigator
      的崎 尚
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      Gunma University
  •  Cell Biology of the Pancreatic Stem CellsPrincipal Investigator

    • Principal Investigator
      KUBOHARA Yuzuru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Institute for Molecular and Cellular Regulation, Gunma University
  •  細胞性粘菌より単離された分化誘導因子DIFの抗腫瘍作用の解析Principal Investigator

    • Principal Investigator
      久保原 禅
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Gunma University
  •  腫瘍細胞の再分化誘導因子の単離/同定と再分化機構の解析Principal Investigator

    • Principal Investigator
      久保原 禅
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  腫瘍細胞の再分化誘導因子の単離/同定と再分化機構の解析Principal Investigator

    • Principal Investigator
      久保原 禅
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] 細胞性粘菌(研究の新展開)~モデル生物、創薬資源、バイオ~2012

    • Author(s)
      阿部知顕、前田靖男(編著)、久保原禅 他(著)
    • Total Pages
      552
    • Publisher
      アイピーシー社
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Book] 群馬に多い病気~生活習慣病を知り、克服する2007

    • Author(s)
      小島至、久保原禅(他7名)、ブックレット群馬大学1
    • Total Pages
      72
    • Publisher
      上毛新聞社刊
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Isolation and Structure Determination of New Pyrones from Dictyostelium spp. Cellar Slime Molds Coincubated with Pseudomonas spp.2024

    • Author(s)
      Nishimura T, Murotani T, Sasaki H, Uekusa Y, Eguchi H, Ishigaki H, Takahashi K, Kubohara Y, Kikuch H.
    • Journal Title

      Molecules

      Volume: 29

    • Data Source
      KAKENHI-PROJECT-22K11759
  • [Journal Article] <i>Dictyostelium</i> Differentiation-inducing Factor Derivatives Reduce the Glycosylation of PD-L1 in MDA-MB-231 Human Breast Cancer Cells2023

    • Author(s)
      Airi Hirayama, Hirotaka Ishigaki, Katsunori Takahashi, Yusuke Miura, Haruhisa Kikuchi, Yuzuru Kubohara
    • Journal Title

      Juntendo Medical Journal

      Volume: 69 Issue: 2 Pages: 105-115

    • DOI

      10.14789/jmj.JMJ22-0039-OA

    • ISSN
      2187-9737, 2188-2126
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Journal Article] Dictyostelium Differentiation-Inducing Factor-1 Promotes Glucose Uptake, at Least in Part, via an AMPK-Dependent Pathway in Mouse 3T3-L1 Cells2021

    • Author(s)
      Kubohara Yuzuru、Homma Yoshimi、Shibata Hiroshi、Oshima Yoshiteru、Kikuchi Haruhisa
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 5 Pages: 2293-2293

    • DOI

      10.3390/ijms22052293

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Journal Article] Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo.2021

    • Author(s)
      Mita T, Hirai M, Maki Y, Nahar S, Yoshida N, Oshima Y, Kikuchi H, Kubohara Y.
    • Journal Title

      Biochem Pharmacol

      Volume: - Pages: 114834-114834

    • DOI

      10.1016/j.bcp.2021.114834

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04074, KAKENHI-PROJECT-18K07095, KAKENHI-PROJECT-19K07139, KAKENHI-PROJECT-20K07466
  • [Journal Article] 炎症性腸疾患の抑制に関わる分子の探索 ―動物モデルを用いた運動の効果―2021

    • Author(s)
      飯泉恭一、重永綾子、都築孝允、川崎広明、山倉文幸、久保原禅
    • Journal Title

      東北女子大学紀要

      Volume: 59 Pages: 15-19

    • NAID

      120007030476

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K11799
  • [Journal Article] Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds2020

    • Author(s)
      Sasaki Hitomi、Kubohara Yuzuru、Ishigaki Hirotaka、Takahashi Katsunori、Eguchi Hiromi、Sugawara Akihiro、Oshima Yoshiteru、Kikuchi Haruhisa
    • Journal Title

      Molecules

      Volume: 25 Issue: 12 Pages: 2895-2895

    • DOI

      10.3390/molecules25122895

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H02837, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
  • [Journal Article] Derivatives of <i>Dictyostelium</i> Differentiation-Inducing Factors Inhibit Serum-Dependent Cell Migration of Murine Osteosarcoma LM8 Cells2019

    • Author(s)
      Kubohara Y, Kikuchi H, Oshima Y.
    • Journal Title

      Juntendo Medical Journal

      Volume: 65 Issue: 1 Pages: 71-76

    • DOI

      10.14789/jmj.2019.65.JMJ18-OA10

    • NAID

      130007631916

    • ISSN
      2187-9737, 2188-2126
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Journal Article] Antimicrobial Activities of Dictyostelium Differentiation-Inducing Factors and Their Derivatives2019

    • Author(s)
      Kubohara Yuzuru、Shiratsuchi Yoshiko、Ishigaki Hirotaka、Takahashi Katsunori、Oshima Yoshiteru、Kikuchi Haruhisa
    • Journal Title

      Biomolecules

      Volume: 9 Issue: 5 Pages: 163-163

    • DOI

      10.3390/biom9050163

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
  • [Journal Article] Halogen-Substituted Derivatives of Dictyostelium Differentiation-Inducing Factor-1 Suppress Serum-Induced Cell Migration of Human Breast Cancer MDA-MB-231 Cells in Vitro2019

    • Author(s)
      Kyoko Totsuka、Yuka Makioka、Kyoichi Iizumi、Katsunori Takahashi、Yoshiteru Oshima、Haruhisa Kikuchi、Yuzuru Kubohara
    • Journal Title

      Biomolecules

      Volume: 9 Issue: 7 Pages: 256-256

    • DOI

      10.3390/biom9070256

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H02837, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
  • [Journal Article] Dictyostelium: an important source of structural and functional diversity in drug discovery.2019

    • Author(s)
      Kubohara Y, Kikuchi H.
    • Journal Title

      Cells

      Volume: 8 Issue: 1 Pages: 6-6

    • DOI

      10.3390/cells8010006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Journal Article] Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion2017

    • Author(s)
      Van Hai Nguyen, Haruhisa Kikuchi, Hikaru Sasaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 5 Pages: 583-588

    • DOI

      10.1016/j.tet.2016.12.040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
  • [Journal Article] Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds2017

    • Author(s)
      Haruhisa Kikuchi, Ikuko Ito, Katsunori Takahashi, Hirotaka Ishigaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
    • Journal Title

      Journal of Natural Products

      Volume: 80 Issue: 10 Pages: 2716-2722

    • DOI

      10.1021/acs.jnatprod.7b00456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
  • [Journal Article] Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from <i>Dictyostelium discoideum</i>2017

    • Author(s)
      Takahashi Katsunori、Kikuchi Haruhisa、Nguyen Van Hai、Oshima Yoshiteru、Ishigaki Hirotaka、Nakajima-Shimada Junko、Kubohara Yuzuru
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 11 Pages: 1941-1947

    • DOI

      10.1248/bpb.b17-00484

    • NAID

      130006191965

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Journal Article] Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.2016

    • Author(s)
      Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y.
    • Journal Title

      Biochem. Biophys. Rep.

      Volume: 8 Pages: 219-226

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Journal Article] Differentiation-inducing factor 2 modulates chemotaxis via the histidine kinase DhkC-dependent pathway in Dictyostelium discoideum.2016

    • Author(s)
      Kuwayama H, & Kubohara Y.
    • Journal Title

      FEBS Lett.

      Volume: 590 Issue: 6 Pages: 760-768

    • DOI

      10.1002/1873-3468.12111

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
  • [Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015

    • Author(s)
      Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
    • Journal Title

      Int. J. Cancer Clinic. Res.

      Volume: 2 Pages: 3-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015

    • Author(s)
      Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
    • Journal Title

      Int. J. Cancer Clinic. Res.

      Volume: 2 Pages: 3-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Journal Article] Development of novel DIF-1 derivatives that selectively suppress innate immune responses.2015

    • Author(s)
      Nguyen VH, Kikuchi H, Kubohara Y, Takahashi K, Katou Y, & Oshima Y.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 15 Pages: 4311-4315

    • DOI

      10.1016/j.bmc.2015.06.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
  • [Journal Article] Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid&#8211;stimulated migration of murine osteosarcoma LM8 cells.2015

    • Author(s)
      Kubohara Y, Komachi M, Homma Y, Kikuchi H, & Oshima Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 463 Issue: 4 Pages: 800-805

    • DOI

      10.1016/j.bbrc.2015.06.016

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
  • [Journal Article] Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum.2014

    • Author(s)
      Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
    • Journal Title

      Biology Open

      Volume: 3 Issue: 4 Pages: 289-296

    • DOI

      10.1242/bio.20146585

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590110, KAKENHI-PROJECT-15K07964
  • [Journal Article] Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo2013

    • Author(s)
      Nakajima-Shimada J, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, & Kubohara Y
    • Journal Title

      Biochemical Pharmacology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Journal Article] Chlorinated Dibenzofurans Isolated from the Cellular Slime Mold, Polysphondylium filamentosum, and Their Biological Activities2013

    • Author(s)
      Kikuchi, H.; Kubohara, Y.; Nguyen, V. H.; Katou, Y.; Oshima, Y. Novel
    • Journal Title

      Bioorg. Med. Chem

      Volume: (In press) Issue: 15 Pages: 4628-4633

    • DOI

      10.1016/j.bmc.2013.05.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
  • [Journal Article] The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.2013

    • Author(s)
      Yamada Y, Kubohara Y, Kikuchi H, Oshima Y, Wang HY, Ross S, & Williams JG.
    • Journal Title

      Intenational Journal of Developmental Biology

      Volume: 57 Issue: 5 Pages: 375-381

    • DOI

      10.1387/ijdb.130046jw

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Journal Article] Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum.2013

    • Author(s)
      Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e72118-e72118

    • DOI

      10.1371/journal.pone.0072118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012

    • Author(s)
      Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K
    • Journal Title

      Brit. J. Pharmacol

      Volume: 165(4) Pages: 870-879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012

    • Author(s)
      Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa KI
    • Journal Title

      British Journal of Pharmacology

      Volume: 165 Issue: 4 Pages: 870-879

    • DOI

      10.1111/j.1476-5381.2011.01541.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090, KAKENHI-PROJECT-23591077
  • [Journal Article] Isolation, Synthesis and Biological Activity of Biphenyl and m-Terphenyl-Type Compounds from Dictyostelium Cellular Slime Molds2012

    • Author(s)
      Kikuchi, H.; Matsuo, Y.; Katou, Y.; Kubohara, Y.; Oshima, Y
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 43 Pages: 8884-8889

    • DOI

      10.1016/j.tet.2012.08.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
  • [Journal Article] Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells2012

    • Author(s)
      Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y
    • Journal Title

      Toxicology Letters

      Volume: 211 Issue: 3 Pages: 312-318

    • DOI

      10.1016/j.toxlet.2012.04.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells2011

    • Author(s)
      Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
    • Journal Title

      Life Sciences

      Volume: 88(11-12) Pages: 480-485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation.2011

    • Author(s)
      Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y.
    • Journal Title

      Cell Structure and Function

      Volume: 36 Pages: 21-26

    • NAID

      130004137560

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Atg1 allows second-signalled autophagic cell death in Dictyostelium2011

    • Author(s)
      Luciani M-F, Giusti C, Harms B, Oshima Y, Kikuchi H, Kubohara Y, Golstein P
    • Journal Title

      Autophagy

      Volume: 7(6) Pages: 501-508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation2011

    • Author(s)
      Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y
    • Journal Title

      Cell Structure and Function

      Volume: 36(1) Pages: 21-26

    • NAID

      130004137560

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.2011

    • Author(s)
      Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
    • Journal Title

      Life Sciences

      Volume: 88 Pages: 480-485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] 細胞性粘菌の細胞分化と走化性運動を制御する低分子化合物2010

    • Author(s)
      久保原禅, 桑山秀一
    • Journal Title

      生化学

      Volume: 82巻12号 Pages: 1132-1137

    • NAID

      10027880258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1. Biochem. Biophys2010

    • Author(s)
      Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y
    • Journal Title

      Res. Commun

      Volume: 396(2) Pages: 364-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds.2010

    • Author(s)
      Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y.
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 6000-6007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity.2010

    • Author(s)
      Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T.
    • Journal Title

      Journal of Pharmacological Sciences 112

      Pages: 320-326

    • NAID

      10027744481

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Autophagy in Dictyostelium : genes and pathways2010

    • Author(s)
      Calvo-Garrido J, Carilla-Latorre S, Kubohara Y, Santos N, Mesquita A, Soldati T, Golstein P, Escalante R
    • Journal Title

      cell death and infection. Autophagy

      Volume: 6(6) Pages: 686-701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds2010

    • Author(s)
      Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y
    • Journal Title

      Tetrahedron

      Volume: 66(32) Pages: 6000-6007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1.2010

    • Author(s)
      Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 396 Pages: 364-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity2010

    • Author(s)
      Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T
    • Journal Title

      J. Pharmacol. Sci

      Volume: 112(3) Pages: 320-326

    • NAID

      10027744481

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] oligosaccharide has suppressive activity against human leukemia cell proliferation2009

    • Author(s)
      Hosomi O, Misawa Y, Takeya AMatahira Y, Sugahara K, Kubohara Y, Yamaura F,& Kudo S. Novel
    • Journal Title

      Glycoconjugate J 26

      Pages: 189-198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors.2009

    • Author(s)
      Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y.
    • Journal Title

      Life Sciences 85

      Pages: 438-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Differentiation-inducing factor-1 and-2 function also as modulators for Dictyostelium chemotaxis2009

    • Author(s)
      Kuwayama H, Kubohara Y
    • Journal Title

      PLoS ONE

      Volume: 4(8)

    • NAID

      120007131231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-1.2009

    • Author(s)
      Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P.
    • Journal Title

      Cell Death & Differentiation 16

      Pages: 564-570

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Novel diterpene pyrone-type compounds, Metarhizin A and B, isolated from entomopathogenic fungus2009

    • Author(s)
      Kikuchi H, Hoshi T, Kitayama M, Sekiya M, Katou Y, Ueda K, Kubohara Y, Sato H, Shimazu M, Kurata S & Oshima Y.
    • Journal Title

      Metarhizium flavoviride and their structural requirements for inhibiting cellular proliferation. Tetrahedron 65

      Pages: 469-477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors2009

    • Author(s)
      Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y
    • Journal Title

      Life Sciences

      Volume: 85(11-12) Pages: 438-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-12009

    • Author(s)
      Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P
    • Journal Title

      Cell Death & Differ

      Volume: 16(4) Pages: 264-570

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis.2009

    • Author(s)
      kuwayama H, Kubohara Y.
    • Journal Title

      PLoS ONE 4

    • NAID

      120007131231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Journal Article] Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium2008

    • Author(s)
      Kikuchi H, Ishiko S, Oshima Y, Gonkan N, Hosaka K & Kubohara Y.
    • Journal Title

      Biochem.Biophys. Res. Commun 377

      Pages: 1012-1017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells2008

    • Author(s)
      Kubohara Y, Kikuchi H & Oshima Y.
    • Journal Title

      Life Sciences 83

      Pages: 608-612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Exploitation of the derivatives of Dictyostelium differentiation inducing fact or 1, which promote glucose consumption in mammalian cells.2008

    • Author(s)
      Kubohara, Y. 他
    • Journal Title

      Life Sciences 83

      Pages: 608-612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] 細胞性粘菌由来の薬理活性物質DIF-1が示す抗腫瘍作用と糖代謝促進作用2007

    • Author(s)
      久保原 禅
    • Journal Title

      細胞工学 26

      Pages: 1052-1053

    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Pharmacological activities of the Dictyostelium differentiation-inducing factor-1 (DIF-1):Cellular slime molds are fascinating lower eukaryotes!2007

    • Author(s)
      Kubohara, Y.
    • Journal Title

      Seikagaku 79

      Pages: 148-151

    • NAID

      10018733652

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca^<2+> and H^+ concentrations in Dictyostelium discoidewn.2007

    • Author(s)
      Kubohara Y, Arai A, Gokan N, Hosaka K.
    • Journal Title

      Develop. Growth & Differ. 49・3

      Pages: 253-264

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] 細胞性粘菌由来の薬理活性物質DIF-1が示す抗腫瘍作用と糖代謝促進作用2007

    • Author(s)
      久保原禅
    • Journal Title

      細胞工学 26

      Pages: 1052-1053

    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] 細胞性粘菌の分化誘導因子DIF-1が示す薬理作用 : 下等生物(粘菌)は面白い2007

    • Author(s)
      久保原 禅
    • Journal Title

      生化学 79・2

      Pages: 148-151

    • NAID

      10018733652

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] 細胞性粘菌の分化誘導因子DIF-1が示す薬理作用 : 下等生物(粘菌)は面白い!2007

    • Author(s)
      久保原 禅
    • Journal Title

      生化学 79

      Pages: 148-151

    • NAID

      10018733652

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca^<2+> and H^+ concentrations in Dictyostelium discoideum.2007

    • Author(s)
      Kubohara, Y., et al.
    • Journal Title

      Develop. Growth & Differ. 49

      Pages: 253-264

    • NAID

      40015330264

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells2007

    • Author(s)
      Omata W, Shibata H, Nagasawa M,Kojima I, Kikuchi H, Oshima Y, Hosaka K,& Kubohara Y
    • Journal Title

      FEBS Journal 274

      Pages: 3392-3404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Dihydrodictyopyrone A and C : New members of dictyopyrone family isolated from Dictyostelium cellular slime molds2007

    • Author(s)
      Kikuchi H, Nakamura K, Kubohara Y, Gokan N, Hosaka K, Maeda Y, & Oshima Y.
    • Journal Title

      Tetrahedron Lett 48

      Pages: 5905-5909

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca~<2+>and H^+ concentrations in Dictyostelium discoideum.2007

    • Author(s)
      Kubohara, Y., et al.
    • Journal Title

      Develop. Growth & Differ. 49

      Pages: 253-264

    • NAID

      40015330264

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 cells.2006

    • Author(s)
      Kikuchi H, Oshima Y, Ichimura A, Gokan N, Hasegawa A, Hosaka K, KuboharaY.
    • Journal Title

      Life Sciences 80・2

      Pages: 160-165

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.2005

    • Author(s)
      Kikuchi H, Saito Y, Sekiya J, Okano Y, Saito M, Nakahata N, Kubohara Y, Oshima Y
    • Journal Title

      J.Org.Chem. 70

      Pages: 8854-8858

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells.2005

    • Author(s)
      Tanaka, S., Akaishi, E., Hosaka, K., Okamura, S., Kubohara, Y.
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 162-167

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005

    • Author(s)
      Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
    • Journal Title

      Biochemical Pharmacology 70

      Pages: 676-685

    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on proliferation of astrocytoma cells.2005

    • Author(s)
      Kikuchi, H., Saito, Y., Sekiya, J., Okano, Y., Saito, M., Nakahata, H., Kubohara, Y., Oshima, Y.
    • Journal Title

      J.Org.Chem. 70

      Pages: 8854-8858

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005

    • Author(s)
      Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
    • Journal Title

      Biochmical Pharmacology 70

      Pages: 676-685

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Structural requirements of Dictyosterium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005

    • Author(s)
      Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y
    • Journal Title

      Biochemical Pharmacolgy 70

      Pages: 676-685

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp.,Promote stalk cell differentiation in Dictyostelium discoideum.2005

    • Author(s)
      Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
    • Journal Title

      Differentiation 73

      Pages: 377-384

    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005

    • Author(s)
      Arai, A., Goto, Y., Hasegawa, A., Hosaka, K., Kikuchi, H., Oshima, Y., Tanaka, S., Kubohara, Y.
    • Journal Title

      Differentiation 73

      Pages: 377-384

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., p romote stalk cell differentiation in Dictyostelium discoideum.2005

    • Author(s)
      Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
    • Journal Title

      Differentiation 73

      Pages: 377-384

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005

    • Author(s)
      Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y
    • Journal Title

      Differentiation 73

      Pages: 377-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells.2005

    • Author(s)
      Gokan, N., Kikuchi, H., Nakamura, K., Oshima, Y., Hosaka, K., Kubohara, Y.
    • Journal Title

      Biochem.Pharmacol. 70

      Pages: 676-685

    • Data Source
      KAKENHI-PROJECT-17590115
  • [Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004

    • Author(s)
      Akaishi E, Narita T, Kawai S, Miwa Y, Sasaguri T, Kubohara Y
    • Journal Title

      Eur J Pharmacol. 485

      Pages: 21-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase(PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004

    • Author(s)
      Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y.
    • Journal Title

      Cancer Research 64

      Pages: 2568-2571

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Structural requirements of dictyopyrones isolated from Dictyosterium spp. in the regulation of Dictyosterium development and in anti-leukemic activity.2004

    • Author(s)
      Kikuchi H, Sasaki K, Maeda Y, Amagai A, Kubohara Y, Oshima Y
    • Journal Title

      Bioorg.Med.Chem. 12

      Pages: 3203-3214

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004

    • Author(s)
      Akaishi, E., Narita, T., Kawai, S., Miwa, Y, Sasaguri, T., Hosaka, K., Kubohara, Y.
    • Journal Title

      Eur.J.Pharmacol. 485

      Pages: 21-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004

    • Author(s)
      Shimizu, K., Murata, T., Tagawa, T., Takahashi, K., Ishikawa, R., Abe, Y, Hosaka, K., Kubohara, Y.
    • Journal Title

      Cancer Res. 64

      Pages: 2568-2571

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity.2004

    • Author(s)
      Kikuchi, H., Sasaki, K., Sekiya, J., Maeda, Y., Amagai, A., Kubohara, Y., Oshima, Y.
    • Journal Title

      Bioorg.Med.Chem. 12

      Pages: 3203-3214

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004

    • Author(s)
      Akaishi E, Narita T, Kawai S, Miw, Hosaka K, Kubohara Y.
    • Journal Title

      Eur J Pharmacol. 485

      Pages: 21-29

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Prespore-to-stalk convertion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004

    • Author(s)
      Kubohara Y, Arai A, Takahashi K, Hosaka K, Okamoto K
    • Journal Title

      Biochem.Biophys.Res.Commun. 320

      Pages: 468-473

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004

    • Author(s)
      Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 320

      Pages: 468-473

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glvcoprotein, wst25 in the cellular slime mould Dictyosterium discoideum.2004

    • Author(s)
      Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 320

      Pages: 468-473

    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Structural requirements of dictyopyrones isolated from Dictyostelium spp.in the regulation of Dictyostelium development and in anti-leukemic activity.2004

    • Author(s)
      Kikuchi H, Sasaki K, Sekiya J, Maeda Y, Amagai A, Kubohara Y, Oshima Y
    • Journal Title

      Bioorg.Med.Chem. 12

      Pages: 3203-3214

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004

    • Author(s)
      Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y
    • Journal Title

      Cancer Research 64

      Pages: 2568-2571

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Journal Article] Calmodulin-dependent cyclic nucleotide phosphoiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004

    • Author(s)
      Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y.
    • Journal Title

      Cancer Research 64

      Pages: 2568-2571

    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003

    • Author(s)
      Takahashi-Yanaga, F., Taba, Y., Miwa, Y., Kubohara, Y., Watanabe, Y., Hirata, M., Morimoto, S., Sasaguri, T.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 9663-9670

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity2003

    • Author(s)
      Akashi E, Narita T, Kawai S, Miwa Y, Sasaguri T, Hosaka K, Kubohara Y.
    • Journal Title

      European Journal of Pharmacology 485

      Pages: 21-29

    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Differentiation-inducing factor-1(DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK dependent pathway.2003

    • Author(s)
      Kanai, M., Konda, Y., Nakajima, T., Izumi, Y, Nanakin, A., Kanda, N., Kubohara, Y., Chiba, T.
    • Journal Title

      Oncogene 22

      Pages: 548-554

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Differentiation-inducing factor-1(DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK dependent pathway.2003

    • Author(s)
      Kanai M, Konda Y, Nakajima T, Izumi Y, Nanakin A, Kanda N, Kubohara Y, Chiba T
    • Journal Title

      Oncogene 22

      Pages: 548-554

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003

    • Author(s)
      Takahashi-Yanaga F, Taba Y, Miwa Y, Kubohara Y, Watanabe Y, Hirata M, Morimoto S, Sasaguri T
    • Journal Title

      J.Biol.Chem. 278

      Pages: 9663-9670

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003

    • Author(s)
      Takahashi K, Akaishi E, Abe Y, Ishikawa R, Tanaka S, Hosaka K, Kubohara Y
    • Journal Title

      Biochem.Biophys.Res.Commun. 307

      Pages: 64-68

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003

    • Author(s)
      Takahashi, N., Akaishi, E., Abe, Y, Ishikawa, R., Tanaka, S., Hosaka, K., Kubohara, Y.
    • Journal Title

      Biochem.Biophys.Res.Commun. 307

      Pages: 64-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Patent] マラリア予防治療薬2021

    • Inventor(s)
      美田敏宏、久保原禅、菊地晴久、大島吉輝
    • Industrial Property Rights Holder
      学校法人 順天堂
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-055575
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Patent] マラリア原虫の増殖抑制剤2019

    • Inventor(s)
      美田敏宏、久保原禅、菊地晴久、大島吉輝
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-040682
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Patent] マラリア原虫の増殖抑制剤2019

    • Inventor(s)
      美田敏宏、久保原禅、菊地晴久、大島吉輝
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-040682
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Patent] アミド誘導体2014

    • Inventor(s)
      菊地晴久、大島吉輝、服部俊夫、久保原禅、他
    • Industrial Property Rights Holder
      東北大学、群馬大学、扶桑薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-038919
    • Filing Date
      2014-02-21
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Patent] ジクチオピロン誘導体又はジヒドロジクチオピロン誘導体を有効成分とするオステオポンチン産生阻害剤2013

    • Inventor(s)
      菊地晴久、大島吉輝、服部俊夫、久保原禅、他
    • Industrial Property Rights Holder
      群馬大学、東北大学、扶桑薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-046197
    • Filing Date
      2013-03-08
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Patent] Method of lowering blood glucose and method of treating diabetes and obesity2010

    • Inventor(s)
      久保原禅, 柴田宏
    • Industrial Property Rights Holder
      群馬大学
    • Acquisition Date
      2010-12-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 抗腫瘍剤2010

    • Inventor(s)
      久保原禅, 保坂公平
    • Industrial Property Rights Holder
      群馬大学
    • Acquisition Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 走化性運動制御剤2010

    • Inventor(s)
      久保原禅, 岡島史和, 小町麻由美, 桑山秀一, 大島吉輝, 菊地晴久
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2010-004319
    • Filing Date
      2010-01-12
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 抗トリパノソーマ剤およびトリパノソーマ症治療薬2010

    • Inventor(s)
      久保原禅, 嶋田淳子
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2010-163039
    • Filing Date
      2010-07-20
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 走化性運動制御剤2010

    • Inventor(s)
      久保原禅、岡島史和、小町麻由美、桑山秀一、大島吉輝、菊地晴久
    • Industrial Property Rights Holder
      久保原禅、桑山秀一、大島吉輝、菊地晴久
    • Industrial Property Number
      2010-004319
    • Filing Date
      2010-01-12
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 抗トリパノソーマ剤およびトリパノソーマ症治療薬2010

    • Inventor(s)
      久保原禅、嶋田淳子
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2010-163039
    • Filing Date
      2010-07-20
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング法2010

    • Inventor(s)
      久保原禅
    • Industrial Property Rights Holder
      群馬大学
    • Acquisition Date
      2010-02-12
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2010

    • Inventor(s)
      久保原禅, 柴田宏
    • Industrial Property Rights Holder
      群馬大学
    • Acquisition Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] インターロイキン-2産生抑制剤2009

    • Inventor(s)
      久保原禅, 村上正巳, 高橋克典, 大島吉輝, 菊地晴久
    • Industrial Property Rights Holder
      群馬大学、東北大学
    • Industrial Property Number
      2009-112974
    • Filing Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 新規DIF-1誘導体2009

    • Inventor(s)
      久保原禅
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2009-02-05
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Patent] 抗腫瘍剤2009

    • Inventor(s)
      久保原禅, 保坂公平
    • Industrial Property Rights Holder
      群馬大学
    • Acquisition Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] インターロイキン-2産生抑制剤2009

    • Inventor(s)
      久保原禅、村上正巳、高橋克典、大島吉輝、菊地晴久
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2009-112974
    • Filing Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Patent] 新規DIF-1誘導体2009

    • Inventor(s)
      久保原禅
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2009-025149
    • Filing Date
      2009-02-05
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Patent] Method of lowering blood glucose and method of preventing or treating blood glucose and method of preventing or treating diabetes and obesity2007

    • Inventor(s)
      久保原禅、柴田宏
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-10-24
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Patent] Method of lowering blood glucose and method of preventing or treating bolld glucose and method of preventing or treating diabetes and obesity2007

    • Inventor(s)
      久保原 禅, 柴田 宏
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-10-24
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Patent] 抗腫瘍剤2006

    • Inventor(s)
      久保原 禅, 保坂 公平
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2006-022530
    • Filing Date
      2006-01-31
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 抗腫瘍剤2006

    • Inventor(s)
      久保原禅, 保坂公平
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2006-022530
    • Filing Date
      2006-01-31
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 細胞性粘菌より単離された新規抗腫瘍因子2005

    • Inventor(s)
      久保原禅, 保坂公平
    • Filing Date
      2005-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590105
  • [Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング方法2005

    • Inventor(s)
      久保原禅
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-166839
    • Filing Date
      2005-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 抗腫瘍剤2005

    • Inventor(s)
      久保原禅, 保坂公平
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-223927
    • Filing Date
      2005-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2005

    • Inventor(s)
      久保原禅, 柴田宏
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-114576
    • Filing Date
      2005-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 抗腫瘍剤2005

    • Inventor(s)
      久保原 禅, 保坂 公平
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-223927
    • Filing Date
      2005-08-02
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2005

    • Inventor(s)
      久保原 禅, 柴田 宏
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-114576
    • Filing Date
      2005-04-12
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング方法2005

    • Inventor(s)
      久保原 禅
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2005-166839
    • Filing Date
      2005-06-07
    • Data Source
      KAKENHI-PROJECT-17590115
  • [Patent] PDE1阻害剤2004

    • Inventor(s)
      久保原禅, 保坂公平, 清水香澄, 村田 琢, 田川俊郎
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2004-108018
    • Filing Date
      2004-03-31
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Patent] PDE1阻害剤2004

    • Inventor(s)
      久保原 禅, 保坂 公平, 清水 香澄, 村田 琢, 田川 俊郎
    • Industrial Property Rights Holder
      群馬大学
    • Industrial Property Number
      2004-108018
    • Filing Date
      2004-03-31
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590123
  • [Presentation] 細胞性粘菌(Dictyostelium discoideum)柄細胞分化誘導因子を用いた新規誘導体の抗マラリア活性2023

    • Author(s)
      吉田菜穂子、平井誠、菊地晴久、久保原禅、美田敏宏
    • Organizer
      日本寄生虫学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] 細胞性粘菌由来の生物活性物質DIF-1とその誘導体によるタンパク質代謝制御機構の解析2022

    • Author(s)
      山田龍,矢野敏史,山越正汰,菊地晴久,久保原禅,原太一
    • Organizer
      日本栄養食糧学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] DIF-1 promotes glucose uptake in mouse C2C12 myotube cells2022

    • Author(s)
      Fukunaga Y, Nakanishi K, Sugita H, Kubohara Y.
    • Organizer
      日本薬理学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] DIF誘導体が熱帯熱マラリア原虫の増殖を阻害する2022

    • Author(s)
      美田敏弘、平井誠、吉田菜穂子、菊地晴久、久保原禅
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] DIF-1による糖代謝促進作用とAMP kinase2020

    • Author(s)
      久保原禅,本間好,大島吉輝,菊地晴久
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] ハロゲン置換した DIF 誘導体の抗腫瘍作用2019

    • Author(s)
      久保原禅, 戸塚響子, 牧岡優佳, 飯泉恭一, 大島吉輝, 菊地晴久
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] DIF誘導体の有する抗菌活性2019

    • Author(s)
      久保原禅, 白土佳子, 石垣宏尚, 高橋克典, 大島吉輝, 菊地晴久
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-19K07139
  • [Presentation] 6-NITROTRYPTOPHAN IN IMMUNOGLOBULIN LIGHT CHAIN AS A NEW POSSIBLE BIOMARKER FOR ATOPIC DERMATITIS2018

    • Author(s)
      Kyoichi Iizumi, Hiroaki Kawasaki, Ayako Shigenaga, Mitsutoshi Tominaga, Ayaka Otsu, Atsuko Kamo, Yayoi Kamata, Yuzuru Kubohara, Kenji Takamori, Fumiyuki Yamakura
    • Organizer
      15th International Society for Tryptophan Research (ISTRY) Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01835
  • [Presentation] 新規DIF-3誘導体、DIF-3(+3)とHex-DIF-3、の生物活性の検討2017

    • Author(s)
      高橋克典、Nguyen Van Hai、菊地晴久、大島吉輝、嶋田淳子、久保原禅
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] DIF-1とその誘導体が有する抗菌活性の研究2017

    • Author(s)
      久保原禅、佐々木啓、菊地晴久、大島吉輝
    • Organizer
      日本細胞性粘菌学会
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] 創薬資源としての細胞性粘菌2017

    • Author(s)
      久保原禅
    • Organizer
      つくば藻類プロティストフォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] DIF-1の機能とミトコンドリアの関係2016

    • Author(s)
      久保原禅、菊地晴久、Nguyen Van Hai、桑山秀一、大島吉輝
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      上智大学(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] DIF-2による粘菌走化性運動の制御メカニズム2015

    • Author(s)
      桑山秀一、久保原禅
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] 1型糖尿病モデルラットの血糖値に対するDIF-1(経口投与)の効果2015

    • Author(s)
      河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] DIF-2による粘菌走化性運動の制御メカニズム2015

    • Author(s)
      桑山秀一、久保原禅
    • Organizer
      日本細胞性粘菌学会第5回例会
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] 1型糖尿病モデルラットの血糖値に対するDIF-1(経口投与)の効果2015

    • Author(s)
      河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
    • Organizer
      日本細胞性粘菌学会第5回例会
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] ヒトがん細胞が高発現するマーカーとオリゴ糖添加による影響2015

    • Author(s)
      牧岡優佳、山本菜々子、久保原禅、細見修
    • Organizer
      第29回日本キチン・キトサン学会大会
    • Place of Presentation
      東海大学熊本キャンパス(熊本県熊本市)
    • Year and Date
      2015-08-20
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] Jurkat T細胞においてマイトジェン刺激で活性化される転写調節因子のマンガンによる影響2015

    • Author(s)
      中島徹、田中進、田中佑季、秋山珠璃、久保原禅、保坂公平
    • Organizer
      日本生化学会第88回大会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] Jurkat T細胞においてマイトジェン刺激で活性化される転写調節因子のマンガンによる影響2015

    • Author(s)
      中島徹、田中進、田中佑季、秋山珠璃、久保原禅、保坂公平
    • Organizer
      日本生化学会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K07964
  • [Presentation] Glutathione S-transferase 4 (GST4) is a putative binding protein for DIFs that regulate the size of fruiting bodies in D. discoideum2014

    • Author(s)
      久保原禅、菊地晴久、大島吉輝、桑山秀一
    • Organizer
      日本細胞性粘菌学会第4回例会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] 細胞性粘菌由来化合物DIF-1誘導体の自然免疫抑制作用とその構造活性相関2014

    • Author(s)
      Van Hai Nguyen、菊地晴久、久保原禅、大島吉輝
    • Organizer
      日本細胞性粘菌学会第4回例会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] Br-DIF-1による胚性癌腫細胞(P19CL6)の1%DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012

    • Author(s)
      瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Br-DIF-1による胚性癌腫細胞 (P19CL6) の1% DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012

    • Author(s)
      瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] P19CL6胚性癌腫細胞の1%DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012

    • Author(s)
      瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] P19CL6胚性癌腫細胞の1% DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012

    • Author(s)
      瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells2011

    • Author(s)
      Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
    • Organizer
      The 28th Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Derivatives of Dictyostelium differentiation-inducing factors regulate mitogen-induced interleukin-2 production in Jurkat cells2011

    • Author(s)
      久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
    • Organizer
      日本細胞生物学会第63回大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-29
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differ entiation of P19CL6 embryonic carcinoma cells2011

    • Author(s)
      Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
    • Organizer
      The 28th Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      東京
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 細胞性粘菌分化誘導因子DIF-3およびその誘導体による抗Trypanosoma cruzi作用の検討2010

    • Author(s)
      細井友夏里, 久保原禅, 畑生俊光, 嶋田淳子
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      旭川
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 細胞性粘菌の分化誘導因子DIF-1とDIF-2は走化性運動の制御因子としても機能する2010

    • Author(s)
      桑山秀一、久保原禅
    • Organizer
      生体運動研究班会議
    • Place of Presentation
      中央大学(東京)
    • Year and Date
      2010-01-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 新規生物資源の開拓ー昆虫寄生糸状菌と卵菌ー2010

    • Author(s)
      菊地晴久, 佐藤雄一, 星朋子, 喜多山実, 関谷瑞樹, 礒辺真人, 三原健, 久保原禅, 佐藤大樹, 島津光明, 加藤泰弘, 倉田祥一朗, 大島吉輝
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 多機能分子DIFの受容体の探索2010

    • Author(s)
      久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
    • Organizer
      第13回細胞性粘菌研究会
    • Place of Presentation
      富山
    • Year and Date
      2010-11-20
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 細胞性粘菌の分化誘導因子DIF-1とDIF-2は走化性運動の制御因子としても機能する2010

    • Author(s)
      桑山秀一, 久保原禅
    • Organizer
      生体運動研究班会議
    • Place of Presentation
      東京
    • Year and Date
      2010-01-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] DIFアミド化誘導体による粘菌柄細胞分化と走化性運動の制御2010

    • Author(s)
      久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
    • Organizer
      第13回細胞性粘菌研究会
    • Place of Presentation
      富山
    • Year and Date
      2010-11-20
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 柄細胞分化誘導因子DIF-1とDIF-2は粘菌走化性運動の制御因子としても機能する2009

    • Author(s)
      桑山秀一, 久保原禅
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Induction of autophagy in mouse fibloblast NIH3T3 cells by DIF-1, a stalk cell differentiation inducing factor of the cellular slime mould Dictyostelium discoideum and its derivatives (DIFs)2009

    • Author(s)
      根津亜季子, 久保原禅, 菊地晴久, 大島吉輝, 山本章嗣
    • Organizer
      第61回日本細胞生物学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009

    • Author(s)
      久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009

    • Author(s)
      久保原禅、高橋克典、村上正巳、菊地晴久、大島吉輝
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口大学(山口市)
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] 柄細胞分化誘導因子DIF-1とDIF-2は粘菌走化性運動の制御因子としても機能する2009

    • Author(s)
      桑山秀一、久保原禅
    • Organizer
      第12回細胞性粘菌研究会
    • Place of Presentation
      山口大学(山口市)
    • Year and Date
      2009-10-10
    • Data Source
      KAKENHI-PROJECT-21590090
  • [Presentation] Biological activities of DIF-1 derivatives.2008

    • Author(s)
      Kubohara, Y. 他
    • Organizer
      International Dictyostelium conference
    • Place of Presentation
      筑波
    • Year and Date
      2008-09-16
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] Biological activities of DIF-1 derivatives2008

    • Author(s)
      Kubohara Y, Kikuchi H,& Oshima Y.
    • Organizer
      International Dictyostelium conference
    • Place of Presentation
      Tsukuba
    • Year and Date
      2008-09-16
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] 胚性癌腫細胞(P19.CL6)の心筋細胞への分化におけるBr-DIF-1の役割2008

    • Author(s)
      瀬谷和彦、(他9名)、久保原禅、古川賢一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] Anti-leukemic activities of Dictyostelium secondary metabolites:A novel aromatic metabolite,4-methyl-5-n-pentylbenzene-1,3-diol,isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells.2007

    • Author(s)
      久保原 禅, 他
    • Organizer
      細胞生物学会・発生生物学会合同学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] 哺乳類細胞に対するDIF-1の糖代謝促進作用2007

    • Author(s)
      久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
    • Organizer
      第10回細胞性粘菌研究会
    • Place of Presentation
      弘前
    • Year and Date
      2007-11-03
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] 哺乳類細胞に対するDIF-1およびその誘導体の糖代謝促進作用2007

    • Author(s)
      久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
    • Organizer
      第10回細胞性粘菌研究会
    • Place of Presentation
      弘前
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] 哺乳類細胞に対するDIF-1の薬理作用2007

    • Author(s)
      久保原 禅
    • Organizer
      第10回細胞性粘菌研究会
    • Place of Presentation
      弘前
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation]2007

    • Author(s)
      久保原禅
    • Organizer
      第10回細胞性粘菌研究会
    • Place of Presentation
      弘前
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5- n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells2007

    • Author(s)
      久保原禅、後閑直美、保坂公平、菊地晴久、大島吉輝
    • Organizer
      細胞生物・発生生物合同学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
    • Data Source
      KAKENHI-PROJECT-19590136
  • [Presentation] 細胞性粘菌由来の薬理活性物質によるインターロイキン-2(IL-2)発現制御

    • Author(s)
      高橋克典,村上正巳,菊池晴久,大島吉輝,久保原禅
    • Organizer
      第59回日本臨床検査医学学術集会
    • Place of Presentation
      京都国際会館
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] 南米シャーガス病の病原虫トリパノソーマに対するDIFの効果

    • Author(s)
      嶋田淳子、細井友夏里、畑生俊光、菊地晴久、大島吉輝、久保原禅
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      京都大学
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] 生物活性の無いDIF-3蛍光体の特性

    • Author(s)
      久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      京都大学
    • Data Source
      KAKENHI-PROJECT-24590110
  • [Presentation] HeLa細胞におけるDIF蛍光体の局在と機能

    • Author(s)
      久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
    • Organizer
      日本細胞性粘菌学会第2回例会
    • Place of Presentation
      東京大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590110
  • 1.  KOJIMA Itaru (60143492)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 2.  HOSAKA Kohei (70108992)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 29 results
  • 3.  OSHIMA Yoshiteru (00111302)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 48 results
  • 4.  菊地 晴久 (90302166)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 5.  IIZUMI Kyoichi (30439351)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  山倉 文幸 (20053358)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  原 太一 (00392374)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 8.  MOGAMI Hideo (90311604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Sugiyama Yoshie (60308210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Sasaki Hiraku (20384969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  的崎 尚 (80252782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  齊藤 宣一 (00334706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  仙葉 隆 (30196985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  永井 敏隆 (40112172)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  手老 篤史 (60431326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  桑山 秀一 (40397659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  池 郁生 (40183157)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  松本 綾子 (20833825)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  川崎 広明 (40531380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  高橋 克典 (90597551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  木村 鮎子 (50553616)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  福永 優子 (80254522)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  美田 敏宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  平井 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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