Watanabe Shiro 渡辺志朗

… Alternative Names

Researcher Number	00222406
Other IDs	https://orcid.org/0000-0003-4435-6992
Affiliation (Current)	2021: 富山大学, 学術研究部薬学・和漢系, 准教授
Affiliation (based on the past Project Information) *help	2019: 富山大学, 学術研究部薬学・和漢系, 准教授 2011 – 2018: 富山大学, 和漢医薬学総合研究所, 准教授 1999 – 2001: 富山医科薬科大学, 和漢薬研究所, 助教授 1997 – 1998: 名古屋市立大学, 薬学部, 講師 1993: 名古屋市立大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / General internal medicine (including Psychosomatic medicine) / General internal medicine(including psychosomatic medicine) / Basic Section 52010:General internal medicine-related Except Principal Investigator Biological pharmacy / 矯正・小児・社会系歯学 / Eating habits / General physiology / Gastroenterology
Keywords	Principal Investigator 胆汁酸 / マクロファージ / エイコサペンタエン酸 / ドコサヘキサエン酸 / FXR / リトコール酸 / alpha-リノレン酸 / リノール酸 / 食餌必須脂肪酸 / 腫瘍壊死因子 … More Except Principal Investigator α-リノレン酸 / α‐リノレン酸 / 炎症 / リノール酸 / ドコサヘキサエン酸 / エイコサペンタエン酸 / 学習能 / アセチルコリン / モノアミン / 神経成長因子 / AMPA受容体 / alpha-linolenic acid / linoleic aicd / docosahexaenoic acid / eicosapentaenoic acid / learning ability / acetylcholine / monoamine / nerve growth factor / 口内炎 / しそ油 / 大豆油 / なたね油 / 脂肪酸構成 / 介入試験 / シソ油 / 植物油 / 二重盲検法 / aphthous stomatitis / perilla oil / soybean oil / rapeseed oil / fatty acid composition / intervention study / 脳虚血モデルマウス / 摂食障害 / 海馬神経細胞死 / 消化管上皮 / 伸展刺激 / ATP放出 / TRPV4 / VNUT / 胃 / ATP / 伸展 / メチル化 / 結腸 / 上皮細胞 Less

Experimental assessment of preventive effects of kampo medicines against metabolic syndromes through the modification of intestinal bile acid metabolismPrincipal InvestigatorOngoing
- Principal Investigator
  
  渡辺志朗
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Toyama
Evaluation of protective effect of dietary supplementation with n-3 fatty acids against feeding disorder following cerebral ischemia in mice
- Principal Investigator
  
  Doshi Masaru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Teikyo University
Role of pregnane X receptor in the preventive effect of Boiogito against experimentally induced cholestatic liver injuryPrincipal Investigator
- Principal Investigator
  
  Watanabe Shiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epithelium
- Principal Investigator
  
  Mihara Hiroshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
  Gastroenterology
- Research Institution
  University of Toyama
Detection of novel actions of kampo medicines for lipid metabolism by lipidomic analysisPrincipal Investigator
- Principal Investigator
  
  SHIRO Watanabe
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama
Prevention of aphtous stomatitis with α-linolenic acid -a double-blind study-
- Principal Investigator
  
  HAMAZAKI Tomohito
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Toyama Medical and Pharmaceutical University
食餌n-3系不飽和脂肪酸がII型糖尿病に及ぼす影響とその機構の解析Principal Investigator
- Principal Investigator
  
  渡辺志朗
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
食餌性n-3系不飽和脂肪酸の生理・病態に及ぼす影響の基礎的研究Principal Investigator
- Principal Investigator
  
  渡辺志朗
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Mechanisms by which dietary oils affect behavioral patterns of rats
- Principal Investigator
  
  OKUYAMA Harumi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
食餌必須脂肪酸バランスによる腫瘍壊死因子(TNF)産生制御の機構に関する研究Principal Investigator
- Principal Investigator
  
  渡辺志朗
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 日本人は絶滅危惧民族　－誤った脂質栄養が拍車―2019
- Author(s)
  大原直樹、小林哲幸、浜　六郎、内野　元、岩本晃明、橋本道男、籠橋有紀子、渡辺志朗、坂井恵子、橋本洋子、立松憲次郎、市川祐子、大西浩之、日比野英彦．
- Total Pages
  126
- Publisher
  中日出版
- ISBN
- Data Source
  KAKENHI-PROJECT-18K07441
[Journal Article] Boiogito prevents dietary lithocholic acid (LCA)‐induced cholestatic liver injury through the suppression of intestinal LCA absorption2019
- Author(s)
  Watanabe Shiro、Chen Zhuoer、Fujita Kyosuke
- Journal Title
  
  Traditional & Kampo Medicine
  
  Volume: 6 Pages: 71-78
- DOI
  10.1002/tkm2.1214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07441
[Journal Article] Ameliorative effect of animal bile preparations on dextran sulfate sodium-induced colitis in mice2018
- Author(s)
  Watanabe Shiro、Fujita Kyosuke、Nishida Takeshi、Imura Johji
- Journal Title
  
  Traditional & Kampo Medicine
  
  Volume: 5 Pages: 67-74
- DOI
  10.1002/tkm2.1094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07441, KAKENHI-PROJECT-17K17746
[Journal Article] Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium2017
- Author(s)
  Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa,Toshiro Sugiyama
- Journal Title
  
  Helicobacter
  
  Volume: 22
- DOI
  10.1111/hel.12361
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Journal Article] Ursodeoxycholic acid suppresses lipogenesis in mouse liver: possible role of the decrease in β-muricholic acid, a farnesoid X receptor antagonist.2017
- Author(s)
  Fujita K., Iguchi Y., Une M., Watanabe S.
- Journal Title
  
  Lipids
  
  Volume: 52 Pages: 335-344
- DOI
  10.1007/s11745-017-4242-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460903
[Journal Article] Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia2016
- Author(s)
  Mihara H, Sugiyama , et al.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22 Pages: 5512-5519
- DOI
  10.3748/wjg.v22.i24.5512
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-26870214
[Journal Article] Dipasperoside B, a new trisiridoid glucoside from Dipsacus asper.2016
- Author(s)
  Li F., Tanaka K., Watanabe S., Tezuka Y.
- Journal Title
  
  Nat. Prod. Commun.
  
  Volume: 11 Pages: 891-894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460903
[Journal Article] Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by Boiogito, a Japanese herbal medicine, in mice.2016
- Author(s)
  Watanabe S, Fujita K, Tsuneyama K, Nose M.
- Journal Title
  
  Trad Kampo Med.
  
  Volume: 3 Pages: 9-19
- DOI
  10.1002/tkm2.1032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460903
[Journal Article] A novel method for determining peroxisomal fatty acid β-oxidation.2016
- Author(s)
  Masashi Morita, Shun Matsumoto, Airi Okazaki, Kaito Tomita, Shiro Watanabe, Kosuke Kawaguchi, Daishiro Minato, Yuji Matsuya, Nobuyuki Shimozawa, Tsuneo Imanaka.
- Journal Title
  
  J Inherit. Metab. Dis.
  
  Volume: 39 Pages: 725-731
- DOI
  10.1007/s10545-016-9952-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04875, KAKENHI-PROJECT-26460063, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-15K15389
[Journal Article] Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia.2015
- Author(s)
  Niu Y, Li F, Inada C, Tanaka K, Watanabe S, Fujiwara H, Sasaki-Hamada S, Oka J, Matsumoto K.
- Journal Title
  
  J Pharm Biomed Anal.
  
  Volume: 104 Pages: 21-30
- DOI
  10.1016/j.jpba.2014.11.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460903
[Journal Article] Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase2015
- Author(s)
  Morita M, Kawamichi M, Shimura Y, Kawaguchi K, Watanabe S, Imanaka T.
- Journal Title
  
  Metab Brain Dis
  
  Volume: 30 Pages: 1359-1367
- DOI
  10.1007/s11011-015-9701-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460063, KAKENHI-PROJECT-26460903
[Journal Article] Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage.2014
- Author(s)
  Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 307
- DOI
  10.1152/ajpgi.00105.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-26870214
[Journal Article] Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues.2014
- Author(s)
  Watanabe S, Fujita K.
- Journal Title
  
  Lipids
  
  Volume: 49 Pages: 963-973
- DOI
  10.1007/s11745-014-3947-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460903
[Journal Article] Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of <i>Dipsacus asper</i>2013
- Author(s)
  Li F., Tanaka K., Watanabe S., Tezuka Y., Saiki I.
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 61 Issue: 12 Pages: 1318-1322
- DOI
  10.1248/cpb.c13-00546
- NAID
  130003381796
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet2013
- Author(s)
  Watanabe S., Tsuneyama K
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 3 Pages: 379-390
- DOI
  10.2131/jts.38.379
- NAID
  10031158904
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Pig bile reduces hepatic triglyceride content in mice.2013
- Author(s)
  Watanabe S., Fujita K
- Journal Title
  
  J. Trad. Med.
  
  Volume: 30 Pages: 190-197
- NAID
  130004942435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Pig bile reduces hepatic triglyceride content in mice2013
- Author(s)
  Watanabe S., Fujita K.
- Journal Title
  
  J. Trad. Med.
  
  Volume: 30 Pages: 190-197
- NAID
  130004942435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet2013
- Author(s)
  Watanabe S., Tsuneyama K.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Pages: 379-390
- NAID
  10031158904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis2013
- Author(s)
  Tanaka K., Li F., Tezuka Y., Watanabe S., Kawahara N., Kida H.
- Journal Title
  
  Nat. Prod. Commun.
  
  Volume: 8 Pages: 75-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS.2012
- Author(s)
  Watanabe K, Ishikawa C, Kuwahara H, Sato K, Komuro S, Nakagawa T, Nomura N, Watanabe S, Yabuki M.
- Journal Title
  
  Anal. Bioanal. Chem.
  
  Volume: 402 Pages: 2033-2042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.2012
- Author(s)
  Watanabe S., Tsuneyama K.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 105-121
- NAID
  10030037499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice : mediation by cholic acid2012
- Author(s)
  Watanabe S., Tsuneyama K.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37 Pages: 105-121
- NAID
  10030037499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Journal Article] Cattle bile aggravates diclofenac sodium-induced small intestinal injury in mice2011
- Author(s)
  Ishikawa H., Watanabe S.
- Journal Title
  
  Evid. Based. Complement. Alternat. Med.
- DOI
  10.1155/2011/315858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 甲状腺ホルモンがマウス脳虚血再潅流後の神経細胞死の発生に及ぼす影響2020
- Author(s)
  道志勝、渡辺志朗、名取雄人、細山田真、赤江豊
- Organizer
  本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] マウスにおける糞便中への脂質排泄に及ぼす五苓散と猪苓湯の影響2020
- Author(s)
  渡辺志朗、馬青苗、陳卓爾
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] がん悪液質モデルマウスに対するオレアノール酸の効果2020
- Author(s)
  藤田恭輔、茶谷大輝、濱田和花、渡辺志朗
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] 防己黄耆湯はリトコール酸（LCA）の腸管での吸収を抑制することによって胆汁うっ滞性肝傷害を軽減する．2019
- Author(s)
  陳卓爾、渡辺志朗、藤田恭輔．
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] エゴマ（Perilla frutescence）の葉の摂取ががん悪液質モデルに与える効果2019
- Author(s)
  藤田恭輔、濱田和花、茶谷大輝、渡辺志朗
- Organizer
  和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] Boiogito modifies bile acid profiles in feces but not liver and cecum in mice.2019
- Author(s)
  陳　卓爾、加賀谷元太、渡辺志朗
- Organizer
  和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] アラキドン酸による容積感受性外向き整流性Cl-チャネルの制御2019
- Author(s)
  吉住志萌、清水貴浩、藤田恭輔、藤井拓人、渡辺志朗、酒井秀紀
- Organizer
  日本薬学会北陸支部第13
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] リトコール酸誘発性胆汁うっ滞モデルにおける肝傷害と肝臓内胆汁蓄積に対する防己黄耆湯の防御効果．2018
- Author(s)
  渡辺志朗、陳　卓爾、加賀谷元太、藤田恭輔．
- Organizer
  和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07441
[Presentation] α-リノレン酸の給餌がマウス脳内炎症応答に及ぼす影響2018
- Author(s)
  道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
- Organizer
  日本薬学会第１３８年会
- Data Source
  KAKENHI-PROJECT-15K00848
[Presentation] 防己黄耆湯のリトコール酸誘導胆汁うっ滞モデルマウスに対する改善効果.2017
- Author(s)
  藤田恭輔, 渡辺志朗. 2017, 3, 24-27, 仙台
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] ヒオデオキシコール酸の投与はTSODマウスの肝臓における炎症・線維化を促進する．2017
- Author(s)
  渡辺志朗、藤田恭輔、西田建志、井村譲二、常山幸一
- Organizer
  TSODマウス研究会情報交換会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] A mechanosensitive ion channel, TRPV4-methylation silencing in gastric epithelium2017
- Author(s)
  Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama
- Organizer
  Congress of the Asian Neurogastroenterology and Motility Association
- Place of Presentation
  Osaka, Japan
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] α‐リノレン酸の給餌が脳リン脂質中エイコサノイド前駆体脂肪酸含量に及ぼす影響2017
- Author(s)
  道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K00848
[Presentation] 脳虚血モデルマウスにみられる摂食障害に対するω３系脂肪酸の軽減効果2016
- Author(s)
  道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K00848
[Presentation] Ursodeoxycholic acid suppresses lipogenesis and reduces lipid contents in mouse liver possibly by reducing β-muricholic acid, a farnesoid X receptor antagonist.2016
- Author(s)
  Shiro Watanabe, Kyosuke Fujita
- Organizer
  The first international symposium on Toyama-Asia-Africa Pharmaceutical network
- Place of Presentation
  富山
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 脳虚血モデルマウスにみられる摂食障害に対するω３系脂肪酸の軽減効果2016
- Author(s)
  道志勝、渡辺志朗、藤田恭輔、富岡直子、細山田真、赤江豊
- Organizer
  日本脂質栄養学会第２５回大会
- Place of Presentation
  秋田市にぎわい交流館AU（秋田市）
- Year and Date
  2016-09-16
- Data Source
  KAKENHI-PROJECT-15K00848
[Presentation] ヒオデオキシコール酸のデキストラン硫酸ナトリウム誘発大腸炎に対する改善効果.2016
- Author(s)
  藤田恭輔, 杉山和恵, 西川将司, 上田浩, 渡辺志朗.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] リトコール酸誘導胆汁うっ滞モデルマウスにおける肝傷害ならびに胆汁酸蓄積に対する防己黄耆湯の軽減効果．2016
- Author(s)
  渡辺志朗、辻哲也、藤田恭輔
- Organizer
  第33回和漢医薬学会学術大会
- Place of Presentation
  東京
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] H. pylori infection directly induces methylation silencing of a gastric epithelial mechano-sensor, Transient Receptor Potential Vanilloid 4 in gastric epithelial cells2016
- Author(s)
  Hiroshi Mihara, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Toshiro Sugiyama
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego, California United States of America
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] 胆汁酸負荷による肝障害に対する防已黄耆湯の軽減効果2015
- Author(s)
  渡辺志朗、藤田恭輔
- Organizer
  第14回日本臨床中医薬学会学術大会
- Place of Presentation
  富山市
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 豚胆主要成分ヒオデオキシコール酸が肥満モデルマウスに与える影響2015
- Author(s)
  藤田恭輔、常山幸一、辻　哲也、渡辺志朗
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山市
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 大柴胡湯の抗肥満作用に関する研究2015
- Author(s)
  小西明伸、荒　哲也，山崎寛生、渡辺志朗、藤田恭輔
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] ヒオデオキシコール酸はTSODマウスにおける肝炎症反応を促進する2015
- Author(s)
  藤田恭輔、常山幸一、渡辺志朗
- Organizer
  第38回胆汁酸研究会
- Place of Presentation
  横浜市
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] Gastrointestinal epithelia could be luminal sensors for chemical, hypo osmolality, acid, temperature and stretch via ATP release.2015
- Author(s)
  Mihara Hiroshi, Sualeh Muhammad Jibran, Suzuki Nobuhiro, Tabuchi Yoshiaki, Sugiyama Toshiro
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870214
[Presentation] TSODマウスの肝炎に及ぼすヒオデオキシコール酸の効果2015
- Author(s)
  藤田恭輔、常山幸一、渡辺志朗
- Organizer
  日本薬学会北陸支部第127回例会
- Place of Presentation
  富山市
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] マウスにおけるヒオデオキシコール酸とウルソデオキシコール酸の脂質低下作用の比較2014
- Author(s)
  渡辺志朗，藤田恭輔
- Organizer
  第36回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 加味四物湯のサルコペニア(筋肉減少症)改善作用の検討(2)2013
- Author(s)
  田邊宏樹、水野弘樹、井上未央里、森智一、中島健一、渡辺志朗、林忠紘、中島賢治、和田篤敬、井上誠
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 防已黄耆湯の胆汁酸誘発性肝障害抑制作用2013
- Author(s)
  藤田恭輔、田中謙、能勢充彦、渡辺志朗
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] ケイヒのLC-MSによる網羅的成分分析と産地特有のマーカー化合物の同定2013
- Author(s)
  田中謙、李峰、渡辺志朗、川原信夫
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Exogenous/endogenous substances detected in the plasma and brain after chitosan treatment in mice.2013
- Author(s)
  牛一民、稲田千香子、趙キ、李峰、渡辺志朗、岡淳一郎、松本欣三
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Exogenous/endogenous substances detected in the plasma and brain after chitosan treatment in mice2013
- Author(s)
  牛一民、稲田千香子、趙キ、李峰、渡辺志朗、岡淳一郎、松本欣三
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 加味四物湯のサルコペニア（筋肉減少症）改善作用の検討（２）2013
- Author(s)
  田邊宏樹、水野弘樹、井上未央里、森智一、中島健一、渡辺志朗、林忠紘、中島賢治、和田篤敬、井上誠
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 豚胆の脂質低下作用2012
- Author(s)
  渡辺志朗、李峰、米山惇志、湖間戸俊輔
- Organizer
  第29回和漢医薬学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-09-12
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Phytochemical study on the root of Dipsacus asper, a Kampo medicine2012
- Author(s)
  李峰、渡辺志朗、手塚康弘、田中謙
- Organizer
  日本生薬学会第59回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] コール酸/高脂肪添加食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012
- Author(s)
  渡辺志朗
- Organizer
  日本脂質栄養学会第21回大会
- Place of Presentation
  麻布
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Eicosapentenoic acid supplementation attenuates hepatic accumulation of cholesterol esters but aggravates liver injury in mice fed a fatand sodium cholate-supplemented diet in mice2012
- Author(s)
  Shiro Watanabe
- Organizer
  The 1st International Conferecence on Pharma and Food
- Place of Presentation
  Shizuoka
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 胆汁酸添加高脂肪食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012
- Author(s)
  渡辺志朗
- Organizer
  胆汁酸研究会
- Place of Presentation
  名古屋
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Phytochemical study on the root of Dipsacus asper, a Kampo medicine.2012
- Author(s)
  李峰、渡辺志朗、手塚康弘、田中謙
- Organizer
  日本生薬学会第59回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching-LC/MS/MS2012
- Author(s)
  渡辺健一,石川千裕,桑原弘,佐藤公彦,小室勢津子,中川徹也,野村成章,矢吹昌司,渡辺志朗
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Eicosapentenoic acid supplementation attenuates hepatic accumulation of cholesterol esters but aggravates liver injury in mice fed a fat- and sodium cholate-supplemented diet in mice2012
- Author(s)
  Shiro Watanabe
- Organizer
  The 1st International Conference on Pharma and Food
- Place of Presentation
  Shizuoka
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 脂肪細胞でのトランス脂肪酸によるインスリン抵抗性に関する解析2011
- Author(s)
  澤田啓介,根橋佳奈,大藏直樹,渡辺志朗,厚味厳一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 牛胆によって誘導される脂質代謝変化と脂肪性肝炎様症状における胆汁酸の役割,2011
- Author(s)
  渡辺志朗
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] トランス脂肪酸は脂肪細胞のインスリン応答性を低下させる2011
- Author(s)
  大嶋利之、澤田啓介、根橋佳奈、大蔵直樹、渡辺志朗、厚味厳一
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 牛胆は一価不飽和脂肪酸含有コレステロールエステルの優位な蓄積を伴う脂肪肝を誘導する2011
- Author(s)
  渡辺志朗,常山幸一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 牛胆によって誘導される脂質代謝変化と脂肪性肝炎様症状における胆汁酸の役割2011
- Author(s)
  渡辺志朗
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] エイコサペンタエン酸がコール酸添加高脂肪食により誘導される脂肪性肝炎様症状に及ぼす影響2011
- Author(s)
  渡辺志朗、吉田康彦、湖間戸俊輔、浜田雄大、常山幸一
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 牛胆の投与によって誘導される脂肪性肝炎様症状に伴う脂質代謝変化の解析2011
- Author(s)
  渡辺志朗
- Organizer
  第12回Pharmaco-hematology Symposium
- Place of Presentation
  富山
- Year and Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] Chemical profiling of endogenous and exogenous markers of chitosan in an animal model of diabetes
- Author(s)
  Niu Yimin, Li Feng, Hironori Fujiwara, Ken Tanaka, Shiro Watanabe, Sachie Sasak-Hamada, Jun-Ichiro Oka, Kinzo Matsumoto
- Organizer
  第31回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 脂肪酸構成の網羅的分析によるコール酸誘発性肝障害とその防已黄耆湯による軽減の機構解析
- Author(s)
  渡辺志朗，藤田恭輔
- Organizer
  第31回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] ヒオデオキシコール酸およびウルソデオキシコール酸の肝臓中トリグリセリド含量低下作用
- Author(s)
  藤田恭輔、松川征也、井上俊、渡辺志朗
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] 大柴胡湯の抗肥満作用の検討
- Author(s)
  林忠紘、荒哲也、和田篤敬、藤田恭輔、渡辺志朗
- Organizer
  日本生薬学会第61年会
- Place of Presentation
  福岡
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-26460903
[Presentation] コール酸誘導性肝傷害および肝臓脂質代謝変動に対する防己黄耆湯の効果
- Author(s)
  藤田恭輔、田中謙、能勢充彦、渡辺志朗
- Organizer
  第35回胆汁酸研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590873
[Presentation] 豚胆の脂質低下作用における主要構成胆汁酸の役割
- Author(s)
  渡辺志朗、藤田恭輔
- Organizer
  第35回胆汁酸研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590873

1. TSUNEYAMA Koichi (10293341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. OKUYAMA Harumi (90080176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IKEMOTO Atsushi (60295615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HAMAZAKI Tomohito (70167592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Doshi Masaru (30392385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Mihara Hiroshi (00612623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. NISHIZONO Hirofumi (10502289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SUGIYAMA Toshiro (00196768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. TOMINAGA Makoto (90260041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. TABUCHI Yoshiaki (20322109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. UCHIDA Kunitoshi (20581135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KOIZUMI Schuichi (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 藤田恭輔 (70707538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
14. YAMAWAKI Hidemoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. SUZUKI Nobuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. KOZAWA Toyomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Fujinami Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. ANDO Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. NANJO Sohachi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. Boudaka Ammar

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. Muhammad Jibran Sualeh

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. 今中常雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 下澤伸行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Shiro 渡辺 志朗

SHIRO Watanabe 渡辺 志朗

WATANABE Shiro 渡辺 志朗

渡辺 志朗 ワタナベ シロウ

Research Projects

Research Products

Co-Researchers

Experimental assessment of preventive effects of kampo medicines against metabolic syndromes through the modification of intestinal bile acid metabolismPrincipal InvestigatorOngoing

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Review Section

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Evaluation of protective effect of dietary supplementation with n-3 fatty acids against feeding disorder following cerebral ischemia in mice

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Role of pregnane X receptor in the preventive effect of Boiogito against experimentally induced cholestatic liver injuryPrincipal Investigator

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Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epithelium

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Detection of novel actions of kampo medicines for lipid metabolism by lipidomic analysisPrincipal Investigator

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Prevention of aphtous stomatitis with α-linolenic acid -a double-blind study-

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食餌n-3系不飽和脂肪酸がII型糖尿病に及ぼす影響とその機構の解析Principal Investigator

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食餌性n-3系不飽和脂肪酸の生理・病態に及ぼす影響の基礎的研究Principal Investigator

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Mechanisms by which dietary oils affect behavioral patterns of rats

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食餌必須脂肪酸バランスによる腫瘍壊死因子(TNF)産生制御の機構に関する研究Principal Investigator

Principal Investigator

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[Book] 日本人は絶滅危惧民族 －誤った脂質栄養が拍車―2019

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[Journal Article] Boiogito prevents dietary lithocholic acid (LCA)‐induced cholestatic liver injury through the suppression of intestinal LCA absorption2019

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[Journal Article] Ameliorative effect of animal bile preparations on dextran sulfate sodium-induced colitis in mice2018

Author(s)

Watanabe Shiro 渡辺志朗

SHIRO Watanabe 渡辺志朗

WATANABE Shiro 渡辺志朗

渡辺志朗ワタナベシロウ

[Book] 日本人は絶滅危惧民族　－誤った脂質栄養が拍車―2019