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Sugiyama Toshiro  杉山 敏郎

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SUGUYAMA Toshiro  杉山 敏郎

SUGIYAMA Toshiro  杉山 敏郎

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Researcher Number 00196768
Other IDs
Affiliation (Current) 2022: 北海道医療大学, 先端研究推進センター, 客員教授
Affiliation (based on the past Project Information) *help 2018: 富山大学, 大学院医学薬学研究部(医学), 特任教授
2011 – 2017: 富山大学, 大学院医学薬学研究部(医学), 教授
2014: 富山大学, 富山大学大学院医学薬学研究部(医学), 教授
2008 – 2010: 富山大学, 医学薬学研究部(医学), 教授
2008 – 2010: 富山大学, 大学院・医学薬学研究部(医学), 教授 … More
2006 – 2007: 富山大学, 大学院・医学薬学研究部, 教授
2006: 富山大学, 大学院医学薬学研究部, 教授
2005: 富山大学, 医学部, 教授
2004 – 2005: 富山医科薬科大学, 医学部, 教授
2003: 北海道大学, 医学部, 助教授
2000 – 2003: 北海道大学, 大学院・医学研究科, 助教授
2001: 北海道大学, 医学部・附属病院, 助教授
1999 – 2000: 北海道大学, 医学部・附属病院, 講師
1998: 北海道大学, 医学部, 講師
1997 – 1998: 北海道大学, 医学部附属病院, 講師
1995 – 1997: 札幌医科大学, 医学部, 講師
1992 – 1993: Sapporo Medical College, Dept. of Int. Med., Assist. Prof., 医学部, 講師
1987 – 1991: 札幌医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology / Biological Sciences
Except Principal Investigator
Gastroenterology / Biological Sciences / Gastroenterology / 内科学一般 / Science and Engineering / Nerve anatomy/Neuropathology / Applied pharmacology / General physiology
Keywords
Principal Investigator
H.pylori / 胃癌 / HELICOBACTER PYLORI / アポトーシス / Carcinoembryonic antigen / Adhesion molecule / Collagen gel / Differentiation / 胃潰瘍 / 再生上皮 … More / NCAM / H^+,K^+-ATPase / gastric ulcer / neural cell adhesion molecule / regeneration / ヘリコバクタ・ピロリ / 胃がん / 腸上皮化生 / TPR-MET再構成 / DNAアレイ / 胃上皮細胞 / クローン病 / CARD15 / Nod2遺伝子 / ヘリコバクター属 / GIST / c-kit / stomach / intestine / gastric GIST / intestinal GIST / GIST / c-kit遺伝子 / 由来臓器悪性度 / Helicobacter pylori / Heat shock protein / Gastritis / HEAT SHOCK PROTEIN / GASTRITIS / カタラーゼ / ワクチン / H.Pylori / CATALASE / VACCINATION / GASTRIC CANCER / 外膜蛋白 / 接着 / 4型分泌機構 / HELICOBACTER PYLOR / OUTER MEMBRANE / ADHESION / TYPE 4 SECRETION MACHINERY / 胃マルトリンパ腫 / API2-MALT1遺伝子転座 / NF-kB / NF-κB / H.pylon / Gastric MALT lymphoma / API2-MALT1 chimeric transcript / NF-kB activation / 非ステロイド系抗炎症剤 / 小腸潰瘍 / 透過性亢進 / TRPV4 / 非ステロイド系抗炎症薬 / 細胞膜透過性亢進 / TRPV4阻害薬 / NSAIDs / 細胞膜透過性 / NSAIDs小腸潰瘍 / NSAIDs / 細胞透過性 … More
Except Principal Investigator
胃癌 / H.pylori / 腸上皮化生 / 萎縮性胃炎 / Helicobacter pylori / モノクローナル抗体 / 抗イディオタイプ抗体 / H. pylori / 胃炎 / 疫学 / H.pylori抗体 / EMR / 抗体遺伝子 / ヘリコバクタ・ピロリ菌 / 慢性胃炎 / モノクロ-ナル抗体 / Campylobacter pylori / CEA / イディオタイプネットワーク / 抗原のインターナルイメージ / Cag A gene / テロメア / テロメラーゼ / TRAP / ヘリコバクター / 胃粘膜萎縮 / 免疫 / 感染宿主 / 人種差 / 遺伝子型 / CagA抗体 / 酵母 / ルシフェラーゼ / 転写因子 / ペルオキシソーム / PPAR / p53 / 除菌 / 未分化癌 / 分化型胃癌 / 感染症 / 抗体医薬 / 細胞チップ / リコンビナント抗体 / リンパ球チップ / 感染症治療 / B細胞 / 抗体産生細胞 / リコンビナント蛋白 / 抗体療法 / 超音波力学 / 多剤耐性遺伝子 / 肝癌 / 分子標的薬 / 劇症肝炎 / 肝マクロファージ / 超音波造影剤 / マクロファージ / マイクロバブル / 腸内細菌 / 前癌病変マーカー / 癌遺伝子 / DNAプローブ / カンピロバクタ・ピロリ菌 / 局所免疫応答 / 胃潰瘍 / 十二指腸潰瘍 / 組織学的重症度 / Chronic Gastritis / Monoclinal antibody / Local immune response / フィブロネクチン / 胃粘膜上皮 / 〓細胞 / 胃粘膜防御機構 / 免疫組織学 / ウエスタンブロット法 / エタノ-ル潰瘍 / 主細胞 / ウェスタンブロット法 / 胃粘膜上位 / Fibronectin / Gastric mucosal epithelium / Chief cell / Gastric mucosal protection / Immunohistology / Western blotting / Ethanol-induced ulcer / ヘリコバタタ・ピロリ菌 / 病態解析 / 胃液 / SIgA / SIgA抗体 / Chronic gastritis / Analysis of the Disease / Gastric juice / sIgA / 早期胃癌 / 疫学研究 / CagA gene / gastritis / intestinal metaplasia / gastric cancer / early gastric cancer / epidemiology / ギランバレー症候群 / ヘリコバクターピロリ / 抗VacA抗体 / Na^+-K^+ ATPase α subunit / ミエリンP0蛋白 / 分子相同性 / 髄液抗HSP抗体 / 自然免疫応答 / 免疫組織化学 / 末梢神経・神経根 / Na^+-K^+ ATPaseαsubunit / ミエリンPO蛋白 / anti-VacA antibody / cerebrospinal fluid / Guillain-Barre syndrome / molecular homology / 潰瘍性大腸炎 / オキサゾロン / ニコチン性アセチルコリン受容体 / 腸管粘膜免疫系 / Th2 / サイトカイン / ニコチン受容体 / ulcerative Colitis / oxazolone / nicotinic acetylcholine receptor s / intestinal mucosal immune system / type-2 helper T cell / cytokine / 自己抗体 / anti-idiotypic antibody / Monoclonal antibody / autoimmune disease / 消化管上皮 / 伸展刺激 / ATP放出 / TRPV4 / VNUT / 胃 / ATP / 伸展 / メチル化 / 結腸 / 上皮細胞 Less
  • Research Projects

    (33 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (60 People)
  •  TRP ion channel related to the pathogenic mechanism of small intestinal ulceration induced by NSAIDs usePrincipal Investigator

    • Principal Investigator
      Sugiyama Toshiro
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Exploitation of a novel therapy for fulminant hepatitis using microbubbles for contrast enhancement ultrasound

    • Principal Investigator
      Minemura Masami
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epithelium

    • Principal Investigator
      Mihara Hiroshi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Oncogenic mechanism of gastro-intestinal stromal tumore using temperature-sensitive transformed Cajal cellsPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Toshiro
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  次世代マイクロチップを用いた単一リンパ球機能のハイスループット解析法の開発

    • Principal Investigator
      村口 篤
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      University of Toyama
  •  Exploitation of the novel therapy for the drug-resistant liver cancer using ultrasonic energy

    • Principal Investigator
      MINEMURA Masami
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  リンパ球マイクロアレイを用いた免疫機能の診断・治療システムの開発

    • Principal Investigator
      村口 篤
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      University of Toyama
  •  Pathophysiological Role of Cholinergic Anti-inflammatory Pathway via Nicotinic Acetylcholine Receptors in Experimental Ulcerative Colitis

    • Principal Investigator
      KADOWAKI Makoto
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      University of Toyama
  •  Helicobacter pylori感染と胃癌粘膜病変の検討 -特に胃癌との関わり

    • Principal Investigator
      浅香 正博
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  クローン病と関連する新規ヘリコバクター属の同定Principal Investigator

    • Principal Investigator
      杉山 敏郎
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
      Toyama Medical and Pharmaceutical University
  •  Helicobacter pylori感染と胃粘膜病変の検討 ―特に胃癌との関わり―

    • Principal Investigator
      浅香 正博
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  An evaluation of anti-VacA antibody and its target molecules in the cerebrospinal fluid of patients with demyelinating form of Guillain-Barre syndrome.

    • Principal Investigator
      CHIBA Susumu
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Sapporo Medical University
  •  Helicobacter pylori感染と胃粘膜病変 ―特に胃癌との関わり―

    • Principal Investigator
      浅香 正博
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  API2-MALT1 translocation and tumorgenesis in gastric MALT lymphomaPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Toshiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Helicobacter pyloriと胃癌粘膜病変 ―特に胃癌との関わり―

    • Principal Investigator
      浅香 正博
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  ヘリコバクター感染による胃癌発症関連宿主因子の同定Principal Investigator

    • Principal Investigator
      杉山 敏郎
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  酵母を用いた消化器癌における転写因子解析システムの開発

    • Principal Investigator
      MORIUCHI Tetsuya
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Basic Research for Development of Vaccination for Gastric Cancer Prevention by Catalase of Helicobacter pyloriPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Toshiro
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  ANALYSIS OF INTERACTION BETWEEN HELICOBACTER AND GASTRC EPITHELIAL CELLS BY YEAST TWO-HYBRID METHODPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Toshiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  H.pylori菌感染症の病型決定因子に関する集学的研究

    • Principal Investigator
      若月 芳雄
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Kyoto University
  •  Helicobacter pylori and gastric cancer

    • Principal Investigator
      ASAKA Masahiro
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Helicobacter pyloriと胃癌発生との関わりについての疫学的研究

    • Principal Investigator
      ASAKA Masahiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  ヘリコバクター感染による胃粘膜萎縮・腸上皮化生・胃癌への進展とテロメラーゼ活性

    • Principal Investigator
      渡辺 直樹
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  EXPRESSION OF HEAT SHOCK PROTEIN ON HELICOBACTER PYLORI INFECTERD GASTRIC MUCOSA AND GASTRITISPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Toshiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      SAPPORO MEDICAL UNIVERSITY
  •  腸上皮化生・胃がんへの進展におけるヘリコバクタ感染とTPR-MET再構成の関連Principal Investigator

    • Principal Investigator
      杉山 敏郎
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  細胞間接着分子CEAおよびBGPの大腸腺管形成における役割と癌化に伴う異常Principal Investigator

    • Principal Investigator
      杉山 敏郎
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  胃潰瘍再生上皮における細胞間接着分子発現とH^+,K^+-ATPaseの関連Principal Investigator

    • Principal Investigator
      杉山 敏郎
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical University
  •  Association of H. pylori with immunological aspects of chronic gastritis

    • Principal Investigator
      YACHI Akira
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical College
  •  抗イディオタイプ・モノクローナル抗体を用いた新しい癌の免疫療法の基礎

    • Principal Investigator
      IMAI Kohzoh
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  Effect of Campylobacter Pylori upon Immunological Conditions of Chronic Gastritis.

    • Principal Investigator
      YACHI Akira
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Sapporo Medical College
  •  Role of Fibronectin-Related Substance Located in Gastric Mucosal Epithelium.

    • Principal Investigator
      YABANA Tsuyoshi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      SAPPORO MEDICAL COLLEGE
  •  分子生物学的・免疫学的方法を用いた肝および大腸前癌マーカーの解析と新しい診断法

    • Principal Investigator
      今井 浩三
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  Analysis of the auto-antibody in the serum from patients by use of anti-idiotypic monoclonal antibodies.

    • Principal Investigator
      YACHI Akira
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Sapporo Medical College

All 2020 2018 2017 2016 2015 2014 2013 2012 2011 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation2020

    • Author(s)
      Mihara H, Sugiyama T et al.
    • Journal Title

      Digestion

      Volume: 99 Pages: 6-11

    • DOI

      10.1159/000504021

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-19K08366
  • [Journal Article] Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium2017

    • Author(s)
      Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa,Toshiro Sugiyama
    • Journal Title

      Helicobacter

      Volume: 22

    • DOI

      10.1111/hel.12361

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Journal Article] Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia2016

    • Author(s)
      Mihara H, Sugiyama , et al.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Pages: 5512-5519

    • DOI

      10.3748/wjg.v22.i24.5512

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08947, KAKENHI-PROJECT-26870214
  • [Journal Article] Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.2015

    • Author(s)
      Suzuki N, Mihara H, Nishizono H, Tominaga M, Sugiyama T.
    • Journal Title

      Dig Dis Sci.

      Volume: 60 Pages: 3570-8

    • DOI

      10.1007/s10620-015-3822-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Journal Article] 特集 消化器疾患の病態生理H.Pylori 感染胃粘膜における TRPV4 メチル化.2015

    • Author(s)
      三原 弘、杉山 敏郎.
    • Journal Title

      Progress in Medicine (ライフ・サイエンス)

      Volume: 35 Pages: 431-433

    • Data Source
      KAKENHI-PROJECT-26870214
  • [Journal Article] Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage.2014

    • Author(s)
      Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 307

    • DOI

      10.1152/ajpgi.00105.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590873, KAKENHI-PROJECT-26460903, KAKENHI-PROJECT-26870214
  • [Journal Article] 消化管間質腫瘍(胃)2014

    • Author(s)
      杉山敏郎
    • Journal Title

      専門医のための消化器病学

      Volume: なし Pages: 147-149

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590912
  • [Journal Article] 胃粘膜下腫瘍(GIST他)2014

    • Author(s)
      杉山敏郎
    • Journal Title

      消化器病診療(第2版)

      Volume: なし Pages: 57-60

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590912
  • [Journal Article] T.Long-term follow-up outcome of imatinib mesylate treatment for recurrent and unresectable gastrointestinal stromal tumors2013

    • Author(s)
      Saito S, Sugiyama T.et al.
    • Journal Title

      Digestion

      Volume: 87 Pages: 47-52

    • DOI

      10.1159/000343938

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590912
  • [Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients.2013

    • Author(s)
      Kanda T, Nishida T, Wada N, Kobayashi O, Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
    • Journal Title

      Int J Clin Oncol.

      Volume: 18 Pages: 38-45

    • DOI

      10.1007/s10147-011-0339-7

    • NAID

      10031176233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-23590912
  • [Journal Article] A gastrointestinal stromal tumor of the stomach demonstrating a stepwise progression from low- to high-grade malignancy2012

    • Author(s)
      Nakajima T, Sugiyama T, et. al.
    • Journal Title

      Case Rep Gastrointest Med

      Volume: 2012 Pages: 1-3

    • DOI

      10.1155/2012/606832

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590912
  • [Journal Article] Differential cytotoxicity and sonosensitization by sanazole : Effect of cell type and acoustic parameters.2011

    • Author(s)
      Hassan M.A., Furusawa Y., Zhao Q.L., Takasaki I., Ferl L.B.Jr., Tachibana K., Minemura M., Sugiyama T., Kondo T.
    • Journal Title

      J.Med.Ultrasonics. 38

      Pages: 65-72

    • NAID

      10029031195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590765
  • [Journal Article] Five-year follow-up study of mother-to-child transmission H.pylori infection detected by a random amplified polymerase DNA fingerprinting method2005

    • Author(s)
      Konno M, Sugiyama T, et al.
    • Journal Title

      J Clin Microbiol 43

      Pages: 2246-2250

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Direct transmission of H.pylori from challenged to nonchallenged mice in a single cage2005

    • Author(s)
      Karita M, Sugiyama T, et al.
    • Journal Title

      Dig Dis Sci 50

      Pages: 1092-1096

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] In vitro induction of resistance to metronidazole and analysis of mutations in rdxA and frxA genes from H.pylori isolates2005

    • Author(s)
      Perez Aldana L, Sugiyama T, et al.
    • Journal Title

      J Infect Chemother 11

      Pages: 59-63

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] A strain-specific antigen in Japanese Helicobacter pylori recognized in sera of Japanese children2005

    • Author(s)
      Okuda M, Sugiyama T, et al.
    • Journal Title

      Clin Diag Lab Immun 12

      Pages: 128-1284

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome.2004

    • Author(s)
      Chiba S, Sugiyama T, Yonekura K, Tanaka S, Matsumoto H, Fujii N, Yokota S, Hirayama T.
    • Journal Title

      Neurology 63

      Pages: 2184-2187

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15500242
  • [Journal Article] Serum Antibodies to H. pylori and its heat-Shock Protein 60 Correlate with the Response of Gastric MALT Lymphoma to Eradication of H. pylori2004

    • Author(s)
      Takenaka R, Sugiyama T
    • Journal Title

      Helicobacter 9

      Pages: 194-200

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Gastric MALT lymphomas are divided into three groups based on responsiveness to H. pylori eradication and detection of API2-MALT1 fusion2004

    • Author(s)
      Inagaki H, Sugiyama T
    • Journal Title

      Am J Surg Pathol 28

      Pages: 1560-1567

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Development of Gastric Cancer associated with H. pylori infection2004

    • Author(s)
      Sugiyama T
    • Journal Title

      Cancer Chemotherapy Pharm 54

      Pages: 12-20

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Helicobacter pylori infection and gastric cancer.2004

    • Author(s)
      Sugiyama T, et al.
    • Journal Title

      Med.Electron Microsc. 37

      Pages: 149-157

    • NAID

      10014171053

    • Data Source
      KAKENHI-PROJECT-16024201
  • [Journal Article] H. pylori infection and Gastric Cancer2004

    • Author(s)
      Sugiyama T
    • Journal Title

      Medical Electron Microscopy 37

      Pages: 149-157

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Melanoidin, a food protein-derived advanced Maillard reaction product, suppresses Helicobacter pylori in vitro and in vivo2004

    • Author(s)
      Hiromoto S, Sugiyama T
    • Journal Title

      Helicobacter 9

      Pages: 439-445

    • Data Source
      KAKENHI-PROJECT-16659178
  • [Journal Article] Antibodies against VacA of Helicobacter pylon can recognize the epitopes of the human peripheral nerve myelin protein.2003

    • Author(s)
      Chiba S, Sugiyama T, Matsumoto H, Yonekura K, Tanaka S et al.
    • Journal Title

      Helicobacter 8(4)

      Pages: 445-445

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15500242
  • [Presentation] Transient Receptor Potential Vanilloid 4 (TRPV4)-Induced Atp Exocytosis from Stomach and Colon Epithelium in Human Cell Lines and Mouse2018

    • Author(s)
      Mihara H, Sugiyama T et al.
    • Organizer
      Digestive Disease Week 2018, Washington DC
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08947
  • [Presentation] 機能性ディスペプシアにおけるTRPV4の関与2018

    • Author(s)
      三原弘、杉山敏郎
    • Organizer
      第 14 回日本消化管学会総会学術集会 コアシンポジウム 3 「消化管機能性疾患の新展開」 -機能性ディスペプシアの病態・標的分子―
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] 機能性ディスペプシアにおけるTRPV4の関与2018

    • Author(s)
      三原 弘、杉山敏郎
    • Organizer
      第14回日本消化管学会総会学術集会コアシンポジウム
    • Data Source
      KAKENHI-PROJECT-15K08947
  • [Presentation] A mechanosensitive ion channel, TRPV4-methylation silencing in gastric epithelium2017

    • Author(s)
      Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama
    • Organizer
      Congress of the Asian Neurogastroenterology and Motility Association
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2017-03-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] マクロファージと細菌の相互作用の検討2016

    • Author(s)
      峯村正実,田尻和人,河合健吾,高木宏明,安村敏,高原照美,杉山敏郎
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      東京ベイ幕張ホール(千葉市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460991
  • [Presentation] Analysis of the Direct Interaction between Macrophages and Microbiota2016

    • Author(s)
      Masami Minemura, Yasuhiro Nakayama, Katsuharu Hirano, Yoshiharu Tokimitsu, Kazuto Tajiri, Kengo Kawai, Hiroshi Kudo, Yutaka Yata, Satoshi Yasumura, Terumi Takahara, and Toshiro Sugiyama
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460991
  • [Presentation] H. pylori infection directly induces methylation silencing of a gastric epithelial mechano-sensor, Transient Receptor Potential Vanilloid 4 in gastric epithelial cells2016

    • Author(s)
      Hiroshi Mihara, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Toshiro Sugiyama
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego, California United States of America
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] Gastrointestinal epithelia could be luminal sensors for chemical, hypo osmolality, acid, temperature and stretch via ATP release.2015

    • Author(s)
      Mihara Hiroshi, Sualeh Muhammad Jibran, Suzuki Nobuhiro, Tabuchi Yoshiaki, Sugiyama Toshiro
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      Washington DC
    • Year and Date
      2015-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] 化合物,低浸透圧,酸,伸展,温度の各種刺激により胃上皮細胞から放出されたATPが胃内の情報を神経に伝達しうる.2014

    • Author(s)
      三原 弘,Muhammad JS,鈴木庸弘,杉山敏郎,田渕圭章.
    • Organizer
      第7回Japan-Functional Dyspepsia research society(J-FD研究会)
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] TRPV4 活性化による胃上皮細胞からのATP 放出機構の破綻が,H. pylori 関連ディスペプシアの一因になり得る.

    • Author(s)
      三原 弘,鈴木庸弘、Muhammad JS,山脇秀元,安藤孝将,藤浪 斗,細川 歩,杉山敏郎
    • Organizer
      第16回日本神経消化器病学会,第8回機能性ディスペプシア研究会,第82回消化器心身医学研究会,第4回IBS研究会 合同学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-06 – 2014-11-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870214
  • [Presentation] What is the role of TRPV4 expressed in gastric epithelium?

    • Author(s)
      Mihara H, Suzuki N, Ando T, Tominaga M, Sugiyama T.
    • Organizer
      The 2nd International Symposium on Mechanobiology (ISMB 2014)
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-20 – 2014-05-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870214
  • 1.  ASAKA Masahiro (10113507)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  YACHI Akira (50045324)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  IMAI Kohzoh (60117603)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  YABANA Tsuyoshi (70045491)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  HINODA Yuji (10165128)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  加藤 元嗣 (60271673)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  TSUJISAKI Masayuki (50217311)
    # of Collaborated Projects: 2 results
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  • 8.  FUJII Nobuhiro (90133719)
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  • 9.  MORIUCHI Tetsuya (20174394)
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 11.  ANDO Takamasa (30600671)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 12.  ENDO Takao (40191928)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  Mihara Hiroshi (00612623)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 14.  千葉 勉 (30188487)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  村口 篤 (20174287)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  北島 勲 (50214797)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  小澤 龍彦 (10432105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  TAKAHARA Terumi (60240777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KOIZUMI Keiichi (10334715)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KONDO Yoshihiro (40205571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KIKUCHI Syogo (40224901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  AKAIKE Takaaki (20231798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  CHIBA Susumu (30167514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 24.  IMAI Tomihiro (40231162)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NONAKA Michio (50363685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KADOWAKI Makoto (20305709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  YAMAMOTO Takeshi (70316181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KURAMOTO Hirofumi (30153373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KADOWAKI Takashi (30185889)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  KAGEYAMA Natsuko (90342865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  NISHIZONO Hirofumi (10502289)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 32.  TOMINAGA Makoto (90260041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 33.  TABUCHI Yoshiaki (20322109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  藤岡 利生 (90145368)
    # of Collaborated Projects: 1 results
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  • 38.  三木 一正 (70107639)
    # of Collaborated Projects: 1 results
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  • 39.  今井 章介 (60232592)
    # of Collaborated Projects: 1 results
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  • 40.  渡辺 直樹 (10158644)
    # of Collaborated Projects: 1 results
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  • 41.  八木橋 厚仁 (40260757)
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  • 44.  菅野 健太郎 (60179116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  中澤 晶子 (40053053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  本多 立 (90377250)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  岸 裕幸 (60186210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  穂刈 格 (70301885)
    # of Collaborated Projects: 1 results
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  • 49.  加藤 康夫 (90185877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  KEIDA Yoshihide
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  OGOSHI Kazuei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  HIRAYAMA Fumihiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  YAMAWAKI Hidemoto
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 54.  SUZUKI Nobuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 55.  KOZAWA Toyomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 60.  廣田 誠一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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