KADOWAKI Makoto 門脇真

Researcher Number	20305709
Other IDs
Affiliation *help	2016 – 2018 : 富山大学, 和漢医薬学総合研究所, 教授 2009 – 2014 : University of Toyama, 和漢医薬学総合研究所, 教授 2012 : 富山大学, 和漢医薬総合研究所, 教授 2005 – 2007 : University of Toyama, Institute of Natural Medicine, Professor, 和漢医薬学総合研究所, 教授 2004 : Institute of Natural Medicine, Division of Gastrointestinal Pathophysiology, Professor, 和漢薬研究所, 教授 2002 – 2003 : 奈良県立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General internal medicine (including Psychosomatic medicine) / General internal medicine(including psychosomatic medicine) / Environmental physiology (including Physical medicine and Nutritional physiology) / Applied pharmacology Except Principal Investigator Environmental pharmacy / Nerve anatomy/Neuropathology / Gastroenterology
Keywords	Principal Investigator 漢方薬 / 樹状細胞 / 食物アレルギー / 腸管粘膜免疫系 / COX-1 / COX-2 / 知覚神経 / capsaicin / 経時的全遺伝子発現解析 / ラット腸管 … More Except Principal Investigator SP / CGRP / IP_3受容体 / 食道壁在性神経細胞 / Fos / Gentiana属生薬 / sensory nerve / Ca channel / 刺五加 / ミトコンドリア / 抗アレルギー / 一酸化窒素作動性神経 / Caチャネル / capsaicin receptor / pacemaker cell / 痴呆 / esophagus / lower esophageal sphincter / タキキニン / 龍胆 / 抗炎症 / エゾウコギ / 筋小胞体 / 品質評価 / キャプサイシン・レセプター / 薬用植物 / 下部食道括約筋 / アレルギー疾患 / 免疫組織化学 / immunohistochemistry / ウィスター・ラット / サブスタンスP(SP) / 抑制反射機構 / 芍薬 / 知覚神経 / 党参 / sarcoplasmic reticulum / ペースメーカー細胞 / 自動運動 / 抑制性反射 / ラット / リアノジン受容体 / interstitial cells of Cajal / IP_3 receptor / autonomic rhythmicity / Wistar rat / mitochondria / 国際協力 / 分子系統学 / 大黄 / 薬用植物学 / ryanodine receptor / カハールの間質細胞 / 秦ギョウ / 迷走神経 Less

漢方薬成分のインシリコ標的タンパク質探索による漢方薬リポジショニングPrincipal InvestigatorOngoing
- Principal Investigator
  
  門脇真
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
漢方薬・大建中湯を応用した慢性大腸炎関連発癌に対する新規薬物治療戦略Principal InvestigatorOngoing
- Principal Investigator
  
  門脇真
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
Construction of a program for sustainable use of traditional medicines, based on integrated study of genetic, chemical and pharmacological diversity of medicinal plants
- Principal Investigator
  
  KOMATSU Katsuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Toyama
Examination of the effects of constituents of traditional Japanese herbal (Kampo) medicines on the migration of plasmacytoid dendritic cells to develop a new therapeutic targetPrincipal Investigator
- Principal Investigator
  
  KADOWAKI MAKOTO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama
Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.Principal Investigator
- Principal Investigator
  
  KADOWAKI Makoto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama
Pathophysiological Role of Cholinergic Anti-inflammatory Pathway via Nicotinic Acetylcholine Receptors in Experimental Ulcerative ColitisPrincipal Investigator
- Principal Investigator
  
  KADOWAKI Makoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Toyama
Inhibitory reflex system by capsaicin-sensitive sensory nerves in lower esophageal sphincter
- Principal Investigator
  
  KURAMOTO Hirofumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto Institute of Technology
Studies on colonic autonomic rhythmicity and its pacemaker mechanism in pathological model animals
- Principal Investigator
  
  TAKAKI Miyako
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nara Medical University
Food allergy and immunologic disease in the intestine : the role of primary afferent neurons in the intestinePrincipal Investigator
- Principal Investigator
  
  KADOWAKI Makoto
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  Nara Medical University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner2014
- Author(s)
  Li P., Zhao Q. L., Wu L. H., Jawaid P., Jiao Y. F., Kadowaki M., Kondo T.
- Journal Title
  
  Apoptois
  
  Volume : 19 Pages : 1043-1053
- DOI
  10.1007/s10495-014-0984-1
- Year and Date
  2014-09-26
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PUBLICLY-25108503, KAKENHI-PROJECT-26670551
[Journal Article] CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells.2014
- Author(s)
  Kim JH., Yamamoto T., Lee J., Yashiro T., Hamada T., Hayashi S., Kadowaki M.
- Journal Title
  
  Biomedical Research
  
  Volume : 35 Pages : 285-293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590879
[Journal Article] Arbutin, an intracellular hydroxyl radical scavenger, protects radiation-induced apoptosis in human lymphoma U937 cells.2014
- Author(s)
  Wu L. H., Li P., Zhao Q. L., Piao J. L., Jiao Y. F., Kadowaki M., Kondo T.
- Journal Title
  
  Apoptosis
  
  Volume : 19 Pages : 1654-1663
- DOI
  10.1007/s10495-014-1032-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879
[Journal Article] Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.2014
- Author(s)
  Yamamoto T., Kodama T., Lee J., Utsunomiya N., Hayashi S., Sakamoto H., Kuramoto H., Kadowaki M.
- Journal Title
  
  PLoS One.
  
  Volume : 9 Pages : 85888-85888
- DOI
  10.1371/journal.pone.0085888
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657, KAKENHI-PROJECT-25460891
[Journal Article] The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells2014
- Author(s)
  Piao J. L., Cui Z. G., Furusawa Y., Ahmed K., Rehman M. U., Tabuchi Y., Kadowaki M., Kondo T.
- Journal Title
  
  Chemico-Biological Interaction
  
  Volume : 205 Pages : 1-28
- DOI
  10.1016/j.cbi.2013.06.011
- Year and Date
  2014-03-21
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PUBLICLY-25108503
[Journal Article] Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.2014
- Author(s)
  Wang X., Hayashi S., Umezaki M., Yamamoto T., Kageyama-Yahara N., Kondo T., Kadowaki M.
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume : 224 Pages : 117-127
- DOI
  10.1016/j.cbi.2014.10.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-25460891
[Journal Article] Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.2014
- Author(s)
  Hayashi S., Hamada T., Zaidi SF., Oshiro M., Lee J., Yamamoto T., Ishii Y., Sasahara M., Kadowaki M.
- Journal Title
  
  Americal Journal of Physiology Gastrointestinal and Liver Physiology
  
  Volume : 307
- DOI
  10.1152/ajpgi.00346.2013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590879
[Journal Article] Morphological demonstration of a vagal inhibitory pathway to the lower esophageal sphincter via nitrergic neurons in the rat esophagus.2013
- Author(s)
  Kuramoto H., Kadowaki M., Yoshida N.
- Journal Title
  
  Neurogastroenterol Motil.
  
  Volume : 25 Pages : 485-94
- DOI
  10.1111/nmo.12146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590879
[Journal Article] Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine model.2013
- Author(s)
  Oda S., Uchida K., Wang X., Lee J., Shimada Y., Tominaga M., Kadowaki M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 465 Pages : 895-900
- DOI
  10.1016/j.bbrc.2012.12.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657, KAKENHI-PROJECT-25460891
[Journal Article] TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells.2013
- Author(s)
  Oda S, Uchida K, Wang X, Lee J, Shimada Y, Tominaga M, Kadowaki M.
- Journal Title
  
  Eur J Physiol
  
  Volume : 465 Pages : 1023-1030
- DOI
  10.1007/s00424-013-1219-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249012, KAKENHI-PROJECT-23790267, KAKENHI-PROJECT-24590879
[Journal Article] Oral tolerance induced by transfer of food antigens via breast milk of allergic mothers prevents offspring from developing allergic symptoms in a mouse food allergy model2012
- Author(s)
  Yamamoto T, Tsubota Y, Kodama T, Kageyama-Yahara N, Kadowaki M
- Journal Title
  
  Clin Dev Immunol.
  
  Volume : 2012 Pages : 721085-721085
- DOI
  10.1155/2012/721085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760, KAKENHI-PROJECT-22790616
[Journal Article] Apoptotic cell death by the novel natural compound, cinobufotalin.2012
- Author(s)
  Emam H
- Journal Title
  
  Chem Biol Interact.
  
  Volume : 199 Pages : 154-160
- DOI
  10.1016/j.cbi.2012.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390229, KAKENHI-PROJECT-24590879
[Journal Article] Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.2012
- Author(s)
  Wang X, Kageyama-Yahara N, Hayashi S, Yamamoto T, Kadowaki M.
- Journal Title
  
  Evidence-Based Complementary and Alternative Medicine.
  
  Volume : 2012 Pages : 862743-862743
- DOI
  10.1155/2012/862743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790616, KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657
[Journal Article] Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells2011
- Author(s)
  Kageyama-Yahara N., Wang X., Katagiri T., Wang P., Yamamoto T., Tominaga M., Kadowaki M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume : 416 Pages : 283-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] Rab5a regulates surface expression of FcεRI and functional activation in mast cells2011
- Author(s)
  Kageyama-Yahara N., Suehiro Y., Yamamoto T., Kadowaki M
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume : 34 Pages : 760-763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] Rab5a regulates surface expression of FcεRI and functional activation in mast cells2011
- Author(s)
  Kageyama-Yahara N, Suehiro Y, Yamamoto T, Kadowaki M
- Journal Title
  
  Biol Pharm Bull
  
  Volume : 34 Pages : 760-3
- DOI
  10.1248/bpb.34.760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760, KAKENHI-PROJECT-22790616
[Journal Article] Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigeninduced extracellular calcium influx and degranulation in mucosal mast cells.2011
- Author(s)
  Kageyama-Yahara N, Wang X, Katagiri T, Wang P, Yamamoto T, Tominaga M, Kadowaki M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 416 Pages : 283-8
- DOI
  10.1016/j.bbrc.2011.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760, KAKENHI-PROJECT-22790616
[Journal Article] Pentagalloy lglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo2010
- Author(s)
  Kageyama-Yahara N., Suehiro Y., Maeda F., Kageyama S., Fukuoka J., Katagiri T., Yamamoto T., Kadowaki M
- Journal Title
  
  FEBS Letter
  
  Volume : 584 Pages : 111-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells2010
- Author(s)
  Kageyama-Yahara N., Wang P., Wang X., Yamamoto T., Kadowaki M
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume : 33 Pages : 142-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells.2010
- Author(s)
  Kageyama-Yahara N., Wang P., Wang X., Yamamoto T., Kadowaki M.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume : 33 Pages : 142-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.2010
- Author(s)
  Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M.
- Journal Title
  
  FEBS Lett. 584
  
  Pages : 111-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.2010
- Author(s)
  Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M.
- Journal Title
  
  FEBS Lett.
  
  Volume : 584 Pages : 111-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590760
[Journal Article] The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition.2008
- Author(s)
  Kadowaki H
- Journal Title
  
  Biomedical Research 29
  
  Pages : 113-117
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590507
[Journal Article] The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition2008
- Author(s)
  Kadowaki H
- Journal Title
  
  Biomedical Research (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590507
[Journal Article] Vagus nerve stimulation preferentially induces Fos expression in nitrergic neurons of rat esophagus2006
- Author(s)
  Hirofumi Kuramoto, Makoto Kadowaki
- Journal Title
  
  Cell and Tissue Research 324(3)
  
  Pages : 361-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Vagus nerve stimulationpreferentially induces Fos expression in nitrergic neurons of rat esophagus2006
- Author(s)
  Hirofumi Kuramoto, Makoto Kadowaki
- Journal Title
  
  Cell and Tissue Research (On line)
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition2006
- Author(s)
  Kadowaki, H
- Journal Title
  
  Biomedical Research 29
  
  Pages : 113-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590507
[Journal Article] Calbindin is predominantly expressed in nitrergic neurons in rat esophagus2006
- Author(s)
  Hirofumi Kuramoto, Makoto Kadowaki, Takeshi Yamamoto, Ryozo Kuwano
- Journal Title
  
  Neuroscience Letters 401(1-2)
  
  Pages : 174-177
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1……2004
- Author(s)
  Makoto Kadowaki, Hirofumi Kuramoto, et al.
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical 116
  
  Pages : 11-18
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.2004
- Author(s)
  Makoto Kadowaki
- Journal Title
  
  Autonomic Neroscience-Basic & Clinical 116
  
  Pages : 11-18
- Data Source
  KAKENHI-PROJECT-14570065
[Journal Article] Combined determination with functionnal and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.2004
- Author(s)
  Makoto Kadowaki
- Journal Title
  
  Autonomic Neuroscience-Basic & Clinical 116
  
  Pages : 11-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570065
[Journal Article] Combined determination with functionnal and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.2004
- Author(s)
  Makoto Kadowaki
- Journal Title
  
  Autonomic Neuroscience : Basic & Clinical 116
  
  Pages : 11-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570065
[Journal Article] Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid lin the myenteric plexus of the rat Jejunum2004
- Author(s)
  Makoto Kadowaki, Hirofumi Kuramoto, Miyako Takaki
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical 116(1)
  
  Pages : 11-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Localization of neurokinin 1 receptor (NK1R) immunoreactivity in rat esophagus2004
- Author(s)
  Hirofumi Kuramoto, Yukio Oomori, Hiroshi Murabayashi, Makoto Kadowaki, Shin-ichiro Karaki, Atsukazu Kuwahara
- Journal Title
  
  The Journal of Comparative Neurology 478(1)
  
  Pages : 11-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum2004
- Author(s)
  Makoto Kadowaki, Hirofumi Kuramoto, Miyako Takaki
- Journal Title
  
  Autonomic Neuroscience Basic and Clinical 116(1)
  
  Pages : 11-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Journal Article] Localization of neurokinin 1 receptor (NK1R) immunoreactivity in rat esophagus2004
- Author(s)
  Hirofumi Kuramoto, Yukio Oomori Hiroshi Murabayashi, Makoto Kadowaki, Shin-Ichiro Karaki, Atsukazu Kuwahara
- Journal Title
  
  The Journal of Comparative Neurology 478(1)
  
  Pages : 1-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500236
[Presentation] 食物アレルギー病態モデルにおける葛根湯の有効性とその免疫学的作用機序2013
- Author(s)
  門脇真
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24406005
[Presentation] 食物アレルギー病態モデルにおける葛根湯の有効性とその免疫学的作用機序2013
- Author(s)
  門脇真
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] Nicotine Suppresses Colonic Tumorigenesis Associated With Chronic Colitis in Mice Through the Inhibition of IL-6 and TNF-α Expression.2013
- Author(s)
  Hayashi S., Hamada T., Kadowaki M.
- Organizer
  Digestive Disease Week
- Place of Presentation
  Orlando, U.S.A.
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] Induction of Foxp3+CD4+ Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto, a Traditional Japanese Herbal Medicine, in a Murine Food Allergy Model．2013
- Author(s)
  Yamamoto T., Kadowaki M.
- Organizer
  16th International Congress of Mucosal Immunology
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] Pathophysiological role of CGRP-expressing intrinsic primary afferent neurons in a murine model of food allergy．2013
- Author(s)
  Lee J., Kim J., Zaidi SF., Kadowaki M.
- Organizer
  8th Congress of International Society for Autonomic Neuroscience
- Place of Presentation
  Giessen, Germany
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] 伝統医薬データーベースの構築（３）2013
- Author(s)
  柴原直利，条美智子，小松かつ子，Zhu Shu，門脇真，山本武，東田千尋，紺野勝弘，数馬恒平
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] Activation of the Cholinergic Anti-Inflammatory Pathway Through Alpha-7 Nicotinic Acetylcholine Receptors Improves Symptoms in Murine Oxazolone-Induced Ulcerative Colitis by Inhibiting Migration of Plasmacytoid Dendritic Cells.2013
- Author(s)
  Yamamoto T., Matsunami E., Kanauchi Y., Kadowaki M.
- Organizer
  Digestive Disease Week
- Place of Presentation
  Orlando, U.S.A.
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] 紫雲膏の主要活性成分シコニンの核内オーファン受容体NR4Aの遺伝子発現抑制を介したマスト細胞に対する作用2012
- Author(s)
  王暁宇,林周作,山本武,門脇真
- Organizer
  第29回和漢医薬学会学術大会
- Place of Presentation
  北里大学薬学部(東京)
- Data Source
  KAKENHI-PROJECT-24406005
[Presentation] 葛根湯の粘膜免疫系での制御性T細胞誘導による食物アレルギー抑制作用2012
- Author(s)
  門脇真
- Organizer
  第16回日本統合医療学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] 腸管免疫性疾患に対する和漢薬からのアプローチ2012
- Author(s)
  門脇真
- Organizer
  第15回天然薬物研究方法論アカデミー
- Place of Presentation
  クロス・ウェーブ船橋(千葉)(招待講演)
- Data Source
  KAKENHI-PROJECT-24406005
[Presentation] α7 ニコチン受容体による JAK2 –カスパーゼの活性化を介した形質細胞様樹状細胞遊走抑制作用.2012
- Author(s)
  山本武，金内優也，林周作，門脇真
- Organizer
  第14回日本神経消化器病学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] 腸管免疫性疾患に対する和漢薬からのアプローチ.2012
- Author(s)
  門脇真
- Organizer
  第15回天然薬物研究方法論アカデミー
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-24590879
[Presentation] 樹状細胞を介した葛根湯によるエフェクターT細胞の分化・増殖の抑制2011
- Author(s)
  山本武,原優加,門脇真
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] Traditional Chinese-Japanese medicine research in mucosal immunity.2010
- Author(s)
  Kadowaki M.
- Organizer
  East-West Scientific Symposia on Allergy & Traditional Oriental Medicine
- Place of Presentation
  Luoyang, China
- Year and Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] 食物アレルギー病態モデルにおける葛根湯の新規制御性T細胞を介した腸管粘膜免疫抑制作用2010
- Author(s)
  山本武,藤原加苗,坪田悠真,門脇真
- Organizer
  第27回和漢医薬学会学術大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] Traditional Chinese-Japanese medicine research in mucosal immunity2010
- Author(s)
  Kadowaki M
- Organizer
  East-West Scientific Symposia on Allergy & Traditional Oriental Medicine
- Place of Presentation
  Luoyang, China
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] 食物アレルギー性消化器症状誘発病態モデルにおける葛根湯による制御性T細胞への分化亢進を介する腸管粘膜免疫系の制御機構(プレナリーセッション講演)2009
- Author(s)
  山本武,藤原加苗,氣賀澤愛,吉田益奈子,門脇真
- Organizer
  第26回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] Effect of kakkonto, a traditional Japanese herbal medicine, on the differentiation of CD4+T cells in the colon of food allergy model mouse2009
- Author(s)
  門脇真
- Organizer
  国際粘膜免疫学会
- Place of Presentation
  ボストンアメリカ合衆国
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] Effect of kakkonto, a traditional Japanese herbal medicine, on the differentiation of CD4+T cells in the colon of food allergy model mouse2009
- Author(s)
  Yamamoto T., Fujiwara K., Yoshida M., Kadowaki M
- Organizer
  International Congress of Mucosal Immunology
- Place of Presentation
  Boston, U. S. A.
- Data Source
  KAKENHI-PROJECT-21590760
[Presentation] Pathophysiological Role of Vagal Anti-inflammatory Pathway via α7-Nicotinic Receptors in Experimental Ulcerative Colitis2007
- Author(s)
  Kadowaki, M
- Organizer
  5th Congress of the International Society for Autonomic Neuroscience
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] Cholinergic anti-inflammatory pathway through α7-nicotinic acetylcholine receptors in the colon reduces oxazolone-induced colitis in mouse2007
- Author(s)
  Kadowaki, M
- Organizer
  Falk Workshop "Mechanisms of Intestinal Inflammation"
- Place of Presentation
  Dresden, Germany
- Year and Date
  2007-10-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] Cholinergic anti-inflammatory pathway through α7-nicotinic acetylcholine receptors in the colon reduces oxazolone-induced colitis in mouse.2007
- Author(s)
  Kadowaki M.
- Organizer
  Falk Workshop"Mechanisms of Intestinal Inflammation"
- Place of Presentation
  Dresden, Germany.
- Year and Date
  2007-10-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] Pathophysiological Role of Vagal Anti-inflammatory Pathway via α7-Nicotinic Receptors in Experimental Ulcerative Colitis.2007
- Author(s)
  Kadowaki M.
- Organizer
  5th Congress of the International Society for Autonomic Neuroscience.
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] Chohnergic anti-inflammatory pathway through α7-nicotinic acetylcholinle receptors in the colon reduces oxazolone-induced colitis in mouse2007
- Author(s)
  Kadowaki M.
- Organizer
  Falk workshop "Mechaisms of Intestinal lnflammation"
- Place of Presentation
  Dresden, Germany
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] Pathophysiological Role of Vagal Anti-inflammatory Pathway via α7-Nicotinic Receptors in Experimental Ulcerative Colitis.2007
- Author(s)
  Kadowaki M.
- Organizer
  5th Congress of the International Society for Autonomic Neuroscience.
- Place of Presentation
  京都
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18590507
[Presentation] ムラサキの生化学研究，特にシコニンの抗アレルギー作用の分子作用機序の研究
- Author(s)
  門脇真
- Organizer
  第1回ムラサキに関するシンポジウム
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24406005

1. KURAMOTO Hirofumi (30153373)

# of Collaborated Projects : 3results

# of Collaborated Products : 8results
2. YAMAMOTO Takeshi (70316181)

# of Collaborated Projects : 3results

# of Collaborated Products : 18results
3. TOHDA Chihiro (10272931)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. KAGEYAMA Natsuko (90342865)

# of Collaborated Projects : 2results

# of Collaborated Products : 10results
5. TAKAKI Miyako (00033358)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. KOMATSU Katsuko (50225570)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. ZHU Shu (20377360)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. KAZUMA Kohei (70552446)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. FUKUI Hiroshi (80145838)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. SUGIYAMA Toshito (00196768)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KADOWAKI Takashi (30185889)

# of Collaborated Projects : 1results

# of Collaborated Products : 9results
12. 柴原直利 (10272907)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 林周作 (10548217)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
14. 山西芳裕 (60437267)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 梅嵜雅人 (80534370)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 富永真琴

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 近藤隆

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KADOWAKI Makoto 門脇 真

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漢方薬成分のインシリコ標的タンパク質探索による漢方薬リポジショニングPrincipal InvestigatorOngoing

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漢方薬・大建中湯を応用した慢性大腸炎関連発癌に対する新規薬物治療戦略Principal InvestigatorOngoing

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Construction of a program for sustainable use of traditional medicines, based on integrated study of genetic, chemical and pharmacological diversity of medicinal plants

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Examination of the effects of constituents of traditional Japanese herbal (Kampo) medicines on the migration of plasmacytoid dendritic cells to develop a new therapeutic targetPrincipal Investigator

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Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.Principal Investigator

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Pathophysiological Role of Cholinergic Anti-inflammatory Pathway via Nicotinic Acetylcholine Receptors in Experimental Ulcerative ColitisPrincipal Investigator

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Inhibitory reflex system by capsaicin-sensitive sensory nerves in lower esophageal sphincter

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Studies on colonic autonomic rhythmicity and its pacemaker mechanism in pathological model animals

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Food allergy and immunologic disease in the intestine : the role of primary afferent neurons in the intestinePrincipal Investigator

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[Journal Article] Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner2014

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[Journal Article] CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells.2014

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[Journal Article] Arbutin, an intracellular hydroxyl radical scavenger, protects radiation-induced apoptosis in human lymphoma U937 cells.2014

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[Journal Article] Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.2014

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[Journal Article] The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells2014

KADOWAKI Makoto 門脇真