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MIYAMAE Takeaki  宮前 丈明

ORCIDConnect your ORCID iD *help
Researcher Number 00239435
Affiliation (based on the past Project Information) *help 1994 – 2000: Yokohama City University Pharmacology Instructor, 医学部, 助手
1999: 横浜市立大学, 医学部・薬理学, 助手
Review Section/Research Field
Principal Investigator
General pharmacology / Neurochemistry/Neuropharmacology
Except Principal Investigator
General pharmacology / 医薬分子機能学 / Neurochemistry/Neuropharmacology / 応用薬理学・医療系薬学
Keywords
Principal Investigator
リン酸化 / オピオイド受容体 / アフリカツメガエル / 弧束核 / 神経伝達物質 / ドーパ / 競合的ドーパ拮抗薬 / パッチクランプ / 孤束核 / カルシウムチャネル … More / ドーパ受容体 / 点変異体 / キメラ変異体 / 情報伝達機構 / 同種脱感作 / 卵母細胞 / プロテインキナーゼC / 脱感作 / GTP結合蛋白質 … More
Except Principal Investigator
ドーパ / 線条体微量透析 / アフリカツメガエル卵母細胞 / クローニング / 4血管閉塞脳虚血 / 神経細胞死因子ドーパ / 神経細胞死 / transporter / L-DOPA / トランスポーター / 孤束核-尾側腹外側延髄ドーパ性投射 / L-ドーパ / 競合的ドーパ拮抗薬 / G蛋白 / 卵母細胞 / アフリカツメガエル / 情報伝達機構 / オピオイド受容体 / グルタミン酸遊離 / ドーパ脱炭酸酵素阻害薬神経細胞死増悪 / 脳虚血上流因子内因性ドーパ / hippocampus / neuronal cell death / ischemia / striatum / baroreceptor reflex / nucleus tractus solitarii / 脳虚血グルタミン酸誘発上流因子内因性ドーパ / ドーパトランスポーター / 高電位活性化Ca^<2+>チャネル電流促進 / 孤束核単離細胞 / 圧受容器情報伝達物質ドーパ / 海馬 / 虚血 / 線条体 / 圧受容体反射 / 弧束核 / cloning / Xenopus laevis oocyte / mutant / C.Elegans / receptor / transmitter / 変異株 / 変異体 / 線虫 / 受容体 / 伝達物質 / metabostatic action / Baculovirus expression system / amphiphilic peptide / Xenopus oocytes / G protein / メタボスタティック作用 / メタボスタ.ティック作用 / バキュロウイルス発現系 / 両親媒性ペプチド / Ca^<2+> influx measured with fura-2 / Causal factor for delayd neuronal cell death / DOPA-induced glutamate release / High voltage-activated Ca^<2+> channel current / Competitive DOPA antagonists / Altered DOPA ergic transmission and maintenance of hypertension / DOPA-GABA-interactions / Transmitter of baroreflex information pathway / グルタミン酸遊離増大 / アセチルコリン遊離抑制 / GTPase活性抑制 / シナプス後D_2受容体伝達効率増強 / 圧受容器反射第一次求心性神経伝達物質 / カルシウム流入増加 / グルタミン酸遊離増大感作作用 / パーキンソン病ラットモデル線条体 / ドーパ性単シナプス性圧受容反射経路 / 高血圧自然発症ラット / 孤束核ドーパ・GABA系相互作用 / ドーパ拮抗薬感受性-高電位活性化Ca^<2+>チャネル電流増大 / 線条体グルタミン酸遊離作用 / 孤束核単離神経パッチクランプ / ドーパ受容体クローニング / DOPA cyclopentyl ester / 強力・安定なドーパ競合的拮抗薬開発 / 腹外側延髄微量透析ドーパ遊離 / 孤束核-腹外側延髄ドーパ性圧受容情報伝達 / fura-2を用いて測定したCa^<2+>流入 / 遅発性神経細胞死原因因子 / ドーパ誘起グルタミン酸遊離 / 高電位活性化Ca^<2+>チャネル電流 / ドーパ性伝達変動と高血圧維持 / ドーパ-GABA-相互作用 / 圧反射情報路伝達物質 / Agonist for "DOPAergic receptors" / Competitive DOPA antagonist / Microinjection into NTS / Basal DOPA release / Basal glutamate release / Microdialysis / Parkinson's model rat striata / DOPA / 内因性ドーパ自発性遊離 / パーキンソン病モデル / 内因性アセチルコリン遊離 / L-ドーパメチルエステル誘導体 / L-ドーパメチルエステル / 弧束核微量注入 / ドーパ作動薬 / 孤束核微量注入 / ドーパ基礎遊離 / グルタミン酸基礎遊離 / 微量透析 / パーキンソン病モデルラット線条体 / G-protein / Cloning / Oocytes / Xenopus Laevis / Signal transduction / Opioid receptor / 発現クローニング / 母細胞 / 情報伝達 / オピオイドレセプター / 〓イノフィンACセプター / 新規競合的拮抗薬DOPA cyclohxyl ester同保護 / 胎仔線条体神経細胞培養系 / 新規ドーパ競合的拮抗薬 / 一過性脳虚血 / グハタミン酸 / 新規競合的拮抗薬DOPA cylohexyl ester 神経細胞死保護 / 胎仔線条体神経細胞培養 / 培養上清 / 生存維持因子 Less
  • Research Projects

    (13 results)
  • Co-Researchers

    (10 People)
  •  ドーパ自体のカルシウムチャネル電流増大作用-孤束核パッチクランプを用いた解析-Principal Investigator

    • Principal Investigator
      宮前 丈明
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yokohama City University
  •  ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用

    • Principal Investigator
      三須 良實
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Yokohama City University
  •  L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rats

    • Principal Investigator
      GOSHIMA Yoshio, 三須 良實
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama City University
  •  ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索

    • Principal Investigator
      MISU Yoshimi
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  脳虚血時、ドーパは同認識部位-グルタミン酸遊離-神経細胞死の要因か?-萠芽的研究

    • Principal Investigator
      古川 信也
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama City University
  •  Identification of molecules mediating DOPAergic neurotransmission-Genetic analysis of DOPA-resistant mutants of C.elegans

    • Principal Investigator
      GOSHIMA Yoshio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yokohama City University School of Medicine
  •  キメラ及び点変異体作成によるオピオイドδ受容体の同種脱感作機構の解析Principal Investigator

    • Principal Investigator
      宮前 丈明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama City University
  •  Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloning

    • Principal Investigator
      MISU Yoshimi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama City University
  •  Expression cloning of metabostatic receptors and its signal transduction

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Nagasaki University
      Yokohama City University
  •  神経細胞コミュニティーに働く液性生存維持因子とその受容体クローニング

    • Principal Investigator
      FUKUSHIMA Nobuyuki
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  アフリカツメガエル卵母細胞発現系を用いたオピオイド受容体の脱感作機構の解析Principal Investigator

    • Principal Investigator
      宮前 丈明
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Yokohama City University
  •  ESTABLISHMENT OF "L-DOPAERGIC RECEPTOR" EXPRESSION SYSTEMS IN PARKINSON'S DISEASE MODEL RATS AND DEVELOPMENT OF L-DOPA-RELATED THERAPEUTIC DRUGS.

    • Principal Investigator
      MISU Yoshimi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE,YOKOHAMA 236, JAPAN.
  •  Cloning, gene expression and signal transduction of opioid kappa-receptor

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Yokohama City Univ.
  • 1.  GOSHIMA Yoshio (00153750)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 2.  FURUKAWA Nobuya (90285114)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  UEDA Hiroshi (00145674)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  MISU Yoshimi (10025687)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  FUKUSHIMA Nobuyuki (10254161)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  SASAKI Yukio (10295511)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  FUJI Kaoru (20027056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KANAI Yoshikatsu (60204533)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KATSURA Isao (00107690)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KOJIMA Atsuyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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