MISU Yoshimi 三須良實

… Alternative Names

三須良実ミスヨシミ

MISY Yoshimi 三須良実

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Researcher Number	10025687
External Links
Affiliation (based on the past Project Information) *help	1994 – 1998: 横浜市立大学, 医学部, 教授 1989 – 1992: 横浜市立大学, 医学部, 教授 1987: Yokohama City University . Professor, 医学部, 教授 1986: 横浜市大, 医学部, 教授
Review Section/Research Field	Principal Investigator General pharmacology / 応用薬理学・医療系薬学 Except Principal Investigator Laboratory animal science
Keywords	Principal Investigator ドーパ / 4血管閉塞脳虚血 / 線条体微量透析 / 神経細胞死因子ドーパ / 線条体 / 孤束核-尾側腹外側延髄ドーパ性投射 / L-ドーパ / 競合的ドーパ拮抗薬 / Microdialysis / DOPA … More / グルタミン酸遊離 / ドーパ脱炭酸酵素阻害薬神経細胞死増悪 / 脳虚血上流因子内因性ドーパ / 視床下部 / 神経活性物質 / シナプス前β-アドレナリン受容体 / ドパミン / Presynaptic inhibitory dopamine receptors / Presynaptic facilitatory <beta>-adrenoceptors / Neuroactive substance / Regulatory actions on dopamine and norepinephrine release / DOPA release / シナプス前ドパミン受容体 / チロシン水酸化酵素 / TTX感受性 / 【Ca^(2+)】依存性 / 神経伝達物質 / ドパミン・ノルエピネフリン遊離制御作用 / シナプス前抑制性ドパミン受容体 / シナプス前促進性β受容体 / ドパミン遊離制御作用 / ドーパ遊離 / hippocampus / transporter / neuronal cell death / ischemia / striatum / baroreceptor reflex / nucleus tractus solitarii / L-DOPA / 脳虚血グルタミン酸誘発上流因子内因性ドーパ / ドーパトランスポーター / 高電位活性化Ca^<2+>チャネル電流促進 / 孤束核単離細胞 / 圧受容器情報伝達物質ドーパ / 海馬 / トランスポーター / 神経細胞死 / 虚血 / 圧受容体反射 / 弧束核 / Ca^<2+> influx measured with fura-2 / Causal factor for delayd neuronal cell death / DOPA-induced glutamate release / High voltage-activated Ca^<2+> channel current / Competitive DOPA antagonists / Altered DOPA ergic transmission and maintenance of hypertension / DOPA-GABA-interactions / Transmitter of baroreflex information pathway / グルタミン酸遊離増大 / アセチルコリン遊離抑制 / GTPase活性抑制 / シナプス後D_2受容体伝達効率増強 / 圧受容器反射第一次求心性神経伝達物質 / カルシウム流入増加 / グルタミン酸遊離増大感作作用 / パーキンソン病ラットモデル線条体 / ドーパ性単シナプス性圧受容反射経路 / 高血圧自然発症ラット / 孤束核ドーパ・GABA系相互作用 / ドーパ拮抗薬感受性-高電位活性化Ca^<2+>チャネル電流増大 / 線条体グルタミン酸遊離作用 / 孤束核単離神経パッチクランプ / ドーパ受容体クローニング / DOPA cyclopentyl ester / 強力・安定なドーパ競合的拮抗薬開発 / 腹外側延髄微量透析ドーパ遊離 / 孤束核-腹外側延髄ドーパ性圧受容情報伝達 / fura-2を用いて測定したCa^<2+>流入 / 遅発性神経細胞死原因因子 / ドーパ誘起グルタミン酸遊離 / 高電位活性化Ca^<2+>チャネル電流 / ドーパ性伝達変動と高血圧維持 / ドーパ-GABA-相互作用 / 圧反射情報路伝達物質 / Agonist for "DOPAergic receptors" / Competitive DOPA antagonist / Microinjection into NTS / Basal DOPA release / Basal glutamate release / Parkinson's model rat striata / 内因性ドーパ自発性遊離 / アフリカツメガエル卵母細胞 / パーキンソン病モデル / 内因性アセチルコリン遊離 / L-ドーパメチルエステル誘導体 / L-ドーパメチルエステル / 弧束核微量注入 / ドーパ作動薬 / 孤束核微量注入 / ドーパ基礎遊離 / グルタミン酸基礎遊離 / 微量透析 / パーキンソン病モデルラット線条体 / D_2-potentiation / Quinpirole / Nicotine / DOPA decarboxylase / Locomotor of rat / Dopamine / 自発運動 / αーメチルパラタイロシン / アセチルコリン受容体 / 伝達物質様遊離 / 自発性遊離 / 脳微量透析法 / ド-パ / ドーパ脱炭素酵素 / D_2-ポテンシエーション / クインピロール / ニコチン / ドーパ脱炭酸酵素 / ラット自発運動 / 脳微量透析 / 新規競合的拮抗薬DOPA cyclohxyl ester同保護 / 胎仔線条体神経細胞培養系 / 新規競合的拮抗薬DOPA cylohexyl ester 神経細胞死保護 / 胎仔線条体神経細胞培養 / ノルアドレナリン / Lースレオドプス / Lード-パメチルエステル / Lード-パ / C57Black mouse / 遊離 / パ-キンソン病 / MPTP / L-ド-パ … More Except Principal Investigator 正常血圧Wistar Kyoto rat / 脳卒中易発症ラット(SHRSP) / 自然発症ラット(SHR) Less

Research Projects
(10 results)
Co-Researchers
(14 People)

ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用Principal Investigator
- Principal Investigator
  
  三須良實
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Yokohama City University
L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in ratsPrincipal Investigator
- Principal Investigator
  
  GOSHIMA Yoshio, 三須良實
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索Principal Investigator
- Principal Investigator
  
  三須良實
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloningPrincipal Investigator
- Principal Investigator
  
  MISU Yoshimi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
高血圧・脳卒中モデルとその対照系統の遺伝的標準化に関する研究
- Principal Investigator
  
  家森幸男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
ESTABLISHMENT OF "L-DOPAERGIC RECEPTOR" EXPRESSION SYSTEMS IN PARKINSON'S DISEASE MODEL RATS AND DEVELOPMENT OF L-DOPA-RELATED THERAPEUTIC DRUGS.Principal Investigator
- Principal Investigator
  
  MISU Yoshimi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE,YOKOHAMA 236, JAPAN.
Is DOPA an neurotransmitter?Principal Investigator
- Principal Investigator
  
  MISU Yoshimi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
ド-パは神経伝達物質たりうるか?ーその競合的拮抗薬並びに高親和性結合部位の探究Principal Investigator
- Principal Investigator
  
  三須良実
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
マウスパ-キンソン病モデル線条体と同生体位におけるド-パのドパミン遊離調節機構Principal Investigator
- Principal Investigator
  
  三須良実
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University
Transmitter-like release of endogenous DOPA and regulatory actions of L-DOPA on the release of dopamine via presynaptic receptors in rat striatal and hypothalamic slices.Principal Investigator
- Principal Investigator
  
  MISY Yoshimi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama City University

1. GOSHIMA Yoshio (00153750)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. MIYAMAE Takeaki (00239435)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. FURUKAWA Nobuya (90285114)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SASAKI Yukio (10295511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEDA Hiroshi (00145674)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKAMURA S. (20207880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJI Kaoru (20027056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUSHIMA Nobuyuki (10254161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 家森幸男 (80025600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 西尾一郎 (40089165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 猿田享男 (70051571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 黒川清 (30167390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 荻原俊男 (60107042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOJIMA Atsuyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MISU Yoshimi 三須 良實

三須 良実 ミス ヨシミ

MISY Yoshimi 三須 良実

Research Projects

Co-Researchers

ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高血圧・脳卒中モデルとその対照系統の遺伝的標準化に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ESTABLISHMENT OF "L-DOPAERGIC RECEPTOR" EXPRESSION SYSTEMS IN PARKINSON'S DISEASE MODEL RATS AND DEVELOPMENT OF L-DOPA-RELATED THERAPEUTIC DRUGS.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Is DOPA an neurotransmitter?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ド-パは神経伝達物質たりうるか?ーその競合的拮抗薬並びに高親和性結合部位の探究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウスパ-キンソン病モデル線条体と同生体位におけるド-パのドパミン遊離調節機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transmitter-like release of endogenous DOPA and regulatory actions of L-DOPA on the release of dopamine via presynaptic receptors in rat striatal and hypothalamic slices.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MISU Yoshimi 三須良實

三須良実ミスヨシミ

MISY Yoshimi 三須良実