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MISU Yoshimi
三須 良實
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Alternative Names
三須 良実 ミス ヨシミ
MISY Yoshimi 三須 良実
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Researcher Number
10025687
External Links
Affiliation (based on the past Project Information)
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1994 – 1998: 横浜市立大学, 医学部, 教授
1989 – 1992: 横浜市立大学, 医学部, 教授
1987: Yokohama City University . Professor, 医学部, 教授
1986: 横浜市大, 医学部, 教授
Review Section/Research Field
Principal Investigator
General pharmacology
/
応用薬理学・医療系薬学
Except Principal Investigator
Laboratory animal science
Keywords
Principal Investigator
ドーパ / 線条体 / 神経細胞死因子ドーパ / 線条体微量透析 / 4血管閉塞脳虚血 / ドパミン / シナプス前β-アドレナリン受容体 / 神経活性物質 / 視床下部 / 脳虚血上流因子内因性ドーパ
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/ ドーパ脱炭酸酵素阻害薬神経細胞死増悪 / グルタミン酸遊離 / DOPA / Microdialysis / 競合的ドーパ拮抗薬 / L-ドーパ / 孤束核-尾側腹外側延髄ドーパ性投射 / L-ド-パ / MPTP / パ-キンソン病 / 遊離 / C57Black mouse / Lード-パ / Lード-パメチルエステル / Lースレオドプス / ノルアドレナリン / 胎仔線条体神経細胞培養 / 新規競合的拮抗薬DOPA cylohexyl ester 神経細胞死保護 / 胎仔線条体神経細胞培養系 / 新規競合的拮抗薬DOPA cyclohxyl ester同保護 / 脳微量透析 / ラット自発運動 / ドーパ脱炭酸酵素 / ニコチン / クインピロール / D_2-ポテンシエーション / ドーパ脱炭素酵素 / ド-パ / 脳微量透析法 / 自発性遊離 / 伝達物質様遊離 / アセチルコリン受容体 / αーメチルパラタイロシン / 自発運動 / Dopamine / Locomotor of rat / DOPA decarboxylase / Nicotine / Quinpirole / D_2-potentiation / パーキンソン病モデルラット線条体 / 微量透析 / グルタミン酸基礎遊離 / ドーパ基礎遊離 / 孤束核微量注入 / ドーパ作動薬 / 弧束核微量注入 / L-ドーパメチルエステル / L-ドーパメチルエステル誘導体 / 内因性アセチルコリン遊離 / パーキンソン病モデル / アフリカツメガエル卵母細胞 / 内因性ドーパ自発性遊離 / Parkinson's model rat striata / Basal glutamate release / Basal DOPA release / Microinjection into NTS / Competitive DOPA antagonist / Agonist for "DOPAergic receptors" / 圧反射情報路伝達物質 / ドーパ-GABA-相互作用 / ドーパ性伝達変動と高血圧維持 / 高電位活性化Ca^<2+>チャネル電流 / ドーパ誘起グルタミン酸遊離 / 遅発性神経細胞死原因因子 / fura-2を用いて測定したCa^<2+>流入 / 孤束核-腹外側延髄ドーパ性圧受容情報伝達 / 腹外側延髄微量透析ドーパ遊離 / 強力・安定なドーパ競合的拮抗薬開発 / DOPA cyclopentyl ester / ドーパ受容体クローニング / 孤束核単離神経パッチクランプ / 線条体グルタミン酸遊離作用 / ドーパ拮抗薬感受性-高電位活性化Ca^<2+>チャネル電流増大 / 孤束核ドーパ・GABA系相互作用 / 高血圧自然発症ラット / ドーパ性単シナプス性圧受容反射経路 / パーキンソン病ラットモデル線条体 / グルタミン酸遊離増大感作作用 / カルシウム流入増加 / 圧受容器反射第一次求心性神経伝達物質 / シナプス後D_2受容体伝達効率増強 / GTPase活性抑制 / アセチルコリン遊離抑制 / グルタミン酸遊離増大 / Transmitter of baroreflex information pathway / DOPA-GABA-interactions / Altered DOPA ergic transmission and maintenance of hypertension / Competitive DOPA antagonists / High voltage-activated Ca^<2+> channel current / DOPA-induced glutamate release / Causal factor for delayd neuronal cell death / Ca^<2+> influx measured with fura-2 / 弧束核 / 圧受容体反射 / 虚血 / 神経細胞死 / トランスポーター / 海馬 / 圧受容器情報伝達物質ドーパ / 孤束核単離細胞 / 高電位活性化Ca^<2+>チャネル電流促進 / ドーパトランスポーター / 脳虚血グルタミン酸誘発上流因子内因性ドーパ / L-DOPA / nucleus tractus solitarii / baroreceptor reflex / striatum / ischemia / neuronal cell death / transporter / hippocampus / ドーパ遊離 / ドパミン遊離制御作用 / シナプス前促進性β受容体 / シナプス前抑制性ドパミン受容体 / ドパミン・ノルエピネフリン遊離制御作用 / 神経伝達物質 / 【Ca^(2+)】依存性 / TTX感受性 / チロシン水酸化酵素 / シナプス前ドパミン受容体 / DOPA release / Regulatory actions on dopamine and norepinephrine release / Neuroactive substance / Presynaptic facilitatory <beta>-adrenoceptors / Presynaptic inhibitory dopamine receptors
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Except Principal Investigator
自然発症ラット(SHR) / 脳卒中易発症ラット(SHRSP) / 正常血圧Wistar Kyoto rat
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Research Projects
(
10
results)
Co-Researchers
(
14
People)
Project Start Year (Newest)
Project Start Year (Oldest)
ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用
Principal Investigator
Principal Investigator
三須 良實
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama City University
L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rats
Principal Investigator
Principal Investigator
GOSHIMA Yoshio
, 三須 良實
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
Yokohama City University
ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索
Principal Investigator
Principal Investigator
三須 良實
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloning
Principal Investigator
Principal Investigator
MISU Yoshimi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
General pharmacology
Research Institution
Yokohama City University
高血圧・脳卒中モデルとその対照系統の遺伝的標準化に関する研究
Principal Investigator
家森 幸男
Project Period (FY)
1994
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Laboratory animal science
Research Institution
Kyoto University
ESTABLISHMENT OF "L-DOPAERGIC RECEPTOR" EXPRESSION SYSTEMS IN PARKINSON'S DISEASE MODEL RATS AND DEVELOPMENT OF L-DOPA-RELATED THERAPEUTIC DRUGS.
Principal Investigator
Principal Investigator
MISU Yoshimi
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
応用薬理学・医療系薬学
Research Institution
YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE,YOKOHAMA 236, JAPAN.
Is DOPA an neurotransmitter?
Principal Investigator
Principal Investigator
MISU Yoshimi
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
General pharmacology
Research Institution
Yokohama City University
ド-パは神経伝達物質たりうるか?ーその競合的拮抗薬並びに高親和性結合部位の探究
Principal Investigator
Principal Investigator
三須 良実
Project Period (FY)
1990
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General pharmacology
Research Institution
Yokohama City University
マウスパ-キンソン病モデル線条体と同生体位におけるド-パのドパミン遊離調節機構
Principal Investigator
Principal Investigator
三須 良実
Project Period (FY)
1989
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General pharmacology
Research Institution
Yokohama City University
Transmitter-like release of endogenous DOPA and regulatory actions of L-DOPA on the release of dopamine via presynaptic receptors in rat striatal and hypothalamic slices.
Principal Investigator
Principal Investigator
MISY Yoshimi
Project Period (FY)
1986 – 1987
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
General pharmacology
Research Institution
Yokohama City University
# of Projects (Dsc)
# of Projects (Asc)
1.
GOSHIMA Yoshio
(00153750)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
2.
MIYAMAE Takeaki
(00239435)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
3.
FURUKAWA Nobuya
(90285114)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
4.
SASAKI Yukio
(10295511)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
UEDA Hiroshi
(00145674)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
NAKAMURA S.
(20207880)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
FUJI Kaoru
(20027056)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
FUKUSHIMA Nobuyuki
(10254161)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
家森 幸男
(80025600)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
西尾 一郎
(40089165)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
猿田 享男
(70051571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
黒川 清
(30167390)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
荻原 俊男
(60107042)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
KOJIMA Atsuyuki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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