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MIYAMAE Takeaki
宮前 丈明
Connect your ORCID iD
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Researcher Number
00239435
Affiliation (based on the past Project Information)
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1994 – 2000: Yokohama City University Pharmacology Instructor, 医学部, 助手
1999: 横浜市立大学, 医学部・薬理学, 助手
Review Section/Research Field
Principal Investigator
General pharmacology
/
Neurochemistry/Neuropharmacology
Except Principal Investigator
General pharmacology
/
医薬分子機能学
/
応用薬理学・医療系薬学
/
Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
アフリカツメガエル / オピオイド受容体 / リン酸化 / GTP結合蛋白質 / 脱感作 / プロテインキナーゼC / 卵母細胞 / 同種脱感作 / 情報伝達機構 / キメラ変異体
…
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/ 点変異体 / ドーパ受容体 / カルシウムチャネル / 孤束核 / パッチクランプ / 競合的ドーパ拮抗薬 / ドーパ / 神経伝達物質 / 弧束核
…
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Except Principal Investigator
線条体微量透析 / ドーパ / 神経細胞死 / 神経細胞死因子ドーパ / 4血管閉塞脳虚血 / クローニング / アフリカツメガエル卵母細胞 / 脳虚血上流因子内因性ドーパ / ドーパ脱炭酸酵素阻害薬神経細胞死増悪 / グルタミン酸遊離 / オピオイド受容体 / 情報伝達機構 / アフリカツメガエル / 卵母細胞 / G蛋白 / 競合的ドーパ拮抗薬 / L-ドーパ / 孤束核-尾側腹外側延髄ドーパ性投射 / トランスポーター / L-DOPA / transporter / 生存維持因子 / 培養上清 / 胎仔線条体神経細胞培養 / 新規競合的拮抗薬DOPA cylohexyl ester 神経細胞死保護 / グハタミン酸 / 一過性脳虚血 / 新規ドーパ競合的拮抗薬 / 胎仔線条体神経細胞培養系 / 新規競合的拮抗薬DOPA cyclohxyl ester同保護 / 〓イノフィンACセプター / オピオイドレセプター / 情報伝達 / 母細胞 / 発現クローニング / Opioid receptor / Signal transduction / Xenopus Laevis / Oocytes / Cloning / G-protein / パーキンソン病モデルラット線条体 / 微量透析 / グルタミン酸基礎遊離 / ドーパ基礎遊離 / 孤束核微量注入 / ドーパ作動薬 / 弧束核微量注入 / L-ドーパメチルエステル / L-ドーパメチルエステル誘導体 / 内因性アセチルコリン遊離 / パーキンソン病モデル / 内因性ドーパ自発性遊離 / DOPA / Parkinson's model rat striata / Microdialysis / Basal glutamate release / Basal DOPA release / Microinjection into NTS / Competitive DOPA antagonist / Agonist for "DOPAergic receptors" / 圧反射情報路伝達物質 / ドーパ-GABA-相互作用 / ドーパ性伝達変動と高血圧維持 / 高電位活性化Ca^<2+>チャネル電流 / ドーパ誘起グルタミン酸遊離 / 遅発性神経細胞死原因因子 / fura-2を用いて測定したCa^<2+>流入 / 孤束核-腹外側延髄ドーパ性圧受容情報伝達 / 腹外側延髄微量透析ドーパ遊離 / 強力・安定なドーパ競合的拮抗薬開発 / DOPA cyclopentyl ester / ドーパ受容体クローニング / 孤束核単離神経パッチクランプ / 線条体グルタミン酸遊離作用 / ドーパ拮抗薬感受性-高電位活性化Ca^<2+>チャネル電流増大 / 孤束核ドーパ・GABA系相互作用 / 高血圧自然発症ラット / ドーパ性単シナプス性圧受容反射経路 / パーキンソン病ラットモデル線条体 / グルタミン酸遊離増大感作作用 / カルシウム流入増加 / 圧受容器反射第一次求心性神経伝達物質 / シナプス後D_2受容体伝達効率増強 / GTPase活性抑制 / アセチルコリン遊離抑制 / グルタミン酸遊離増大 / Transmitter of baroreflex information pathway / DOPA-GABA-interactions / Altered DOPA ergic transmission and maintenance of hypertension / Competitive DOPA antagonists / High voltage-activated Ca^<2+> channel current / DOPA-induced glutamate release / Causal factor for delayd neuronal cell death / Ca^<2+> influx measured with fura-2 / 両親媒性ペプチド / バキュロウイルス発現系 / メタボスタ.ティック作用 / メタボスタティック作用 / G protein / Xenopus oocytes / amphiphilic peptide / Baculovirus expression system / metabostatic action / 伝達物質 / 受容体 / 線虫 / 変異体 / 変異株 / transmitter / receptor / C.Elegans / mutant / Xenopus laevis oocyte / cloning / 弧束核 / 圧受容体反射 / 線条体 / 虚血 / 海馬 / 圧受容器情報伝達物質ドーパ / 孤束核単離細胞 / 高電位活性化Ca^<2+>チャネル電流促進 / ドーパトランスポーター / 脳虚血グルタミン酸誘発上流因子内因性ドーパ / nucleus tractus solitarii / baroreceptor reflex / striatum / ischemia / neuronal cell death / hippocampus
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Research Projects
(
13
results)
Co-Researchers
(
10
People)
Project Start Year (Newest)
Project Start Year (Oldest)
ドーパ自体のカルシウムチャネル電流増大作用-孤束核パッチクランプを用いた解析-
Principal Investigator
Principal Investigator
宮前 丈明
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Yokohama City University
ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用
Principal Investigator
三須 良實
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama City University
L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rats
Principal Investigator
GOSHIMA Yoshio
,
三須 良實
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
Yokohama City University
ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索
Principal Investigator
MISU Yoshimi
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
脳虚血時、ドーパは同認識部位-グルタミン酸遊離-神経細胞死の要因か?-萠芽的研究
Principal Investigator
古川 信也
Project Period (FY)
1997
Research Category
Grant-in-Aid for Exploratory Research
Research Field
General pharmacology
Research Institution
Yokohama City University
Identification of molecules mediating DOPAergic neurotransmission-Genetic analysis of DOPA-resistant mutants of C.elegans
Principal Investigator
GOSHIMA Yoshio
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Yokohama City University School of Medicine
キメラ及び点変異体作成によるオピオイドδ受容体の同種脱感作機構の解析
Principal Investigator
Principal Investigator
宮前 丈明
Project Period (FY)
1995
Research Category
Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field
General pharmacology
Research Institution
Yokohama City University
Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloning
Principal Investigator
MISU Yoshimi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
General pharmacology
Research Institution
Yokohama City University
Expression cloning of metabostatic receptors and its signal transduction
Principal Investigator
UEDA Hiroshi
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
Nagasaki University
Yokohama City University
神経細胞コミュニティーに働く液性生存維持因子とその受容体クローニング
Principal Investigator
FUKUSHIMA Nobuyuki
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
アフリカツメガエル卵母細胞発現系を用いたオピオイド受容体の脱感作機構の解析
Principal Investigator
Principal Investigator
宮前 丈明
Project Period (FY)
1994
Research Category
Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field
General pharmacology
Research Institution
Yokohama City University
ESTABLISHMENT OF "L-DOPAERGIC RECEPTOR" EXPRESSION SYSTEMS IN PARKINSON'S DISEASE MODEL RATS AND DEVELOPMENT OF L-DOPA-RELATED THERAPEUTIC DRUGS.
Principal Investigator
MISU Yoshimi
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
応用薬理学・医療系薬学
Research Institution
YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE,YOKOHAMA 236, JAPAN.
Cloning, gene expression and signal transduction of opioid kappa-receptor
Principal Investigator
UEDA Hiroshi
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
Yokohama City Univ.
# of Projects (Dsc)
# of Projects (Asc)
1.
GOSHIMA Yoshio
(00153750)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
2.
FURUKAWA Nobuya
(90285114)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
3.
UEDA Hiroshi
(00145674)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
MISU Yoshimi
(10025687)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
5.
FUKUSHIMA Nobuyuki
(10254161)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
6.
SASAKI Yukio
(10295511)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
FUJI Kaoru
(20027056)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
KANAI Yoshikatsu
(60204533)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
KATSURA Isao
(00107690)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
KOJIMA Atsuyuki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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