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FURUKAWA Nobuya
古川 信也
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Researcher Number
90285114
External Links
Affiliation
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1997 – 1998 : Yokohama City Univ.Sch.Med., Dept.Pharmacol., Res. Assoc., 医学部, 助手
Review Section/Research Field
Principal Investigator
General pharmacology
Except Principal Investigator
General pharmacology
/
Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
神経細胞死 / 新規ドーパ競合的拮抗薬 / ドーパ / 一過性脳虚血 / 線条体微量透析 / グハタミン酸
Except Principal Investigator
神経細胞死因子ドーパ / 4血管閉塞脳虚血 / 孤束核-尾側腹外側延髄ドーパ性投射 / グルタミン酸遊離
…
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/ ドーパ / 線条体微量透析 / トランスポーター / ドーパ脱炭酸酵素阻害薬神経細胞死増悪 / 脳虚血上流因子内因性ドーパ / transporter / L-DOPA / 孤束核単離細胞 / mutant / 弧束核 / 圧反射情報路伝達物質 / fura-2を用いて測定したCa^<2+>流入 / 海馬 / 強力・安定なドーパ競合的拮抗薬開発 / カルシウム流入増加 / 変異株 / receptor / ドーパ受容体クローニング / Xenopus laevis oocyte / baroreceptor reflex / 脳虚血グルタミン酸誘発上流因子内因性ドーパ / 圧受容体反射 / 線条体グルタミン酸遊離作用 / DOPA cyclopentyl ester / 孤束核単離神経パッチクランプ / 受容体 / 腹外側延髄微量透析ドーパ遊離 / 神経細胞死 / クローニング / ドーパ-GABA-相互作用 / ドーパ性伝達変動と高血圧維持 / シナプス後D_2受容体伝達効率増強 / 競合的ドーパ拮抗薬 / Competitive DOPA antagonists / 孤束核ドーパ・GABA系相互作用 / 新規競合的拮抗薬DOPA cyclohxyl ester同保護 / 高血圧自然発症ラット / L-ドーパ / パーキンソン病ラットモデル線条体 / グルタミン酸遊離増大感作作用 / DOPA-induced glutamate release / High voltage-activated Ca^<2+> channel current / hippocampus / 変異体 / 孤束核-腹外側延髄ドーパ性圧受容情報伝達 / アフリカツメガエル卵母細胞 / 虚血 / 伝達物質 / 高電位活性化Ca^<2+>チャネル電流促進 / C.Elegans / striatum / Transmitter of baroreflex information pathway / ドーパ誘起グルタミン酸遊離 / 胎仔線条体神経細胞培養系 / Ca^<2+> influx measured with fura-2 / アセチルコリン遊離抑制 / transmitter / nucleus tractus solitarii / 圧受容器情報伝達物質ドーパ / 線虫 / DOPA-GABA-interactions / GTPase活性抑制 / 新規競合的拮抗薬DOPA cylohexyl ester 神経細胞死保護 / Causal factor for delayd neuronal cell death / ドーパ性単シナプス性圧受容反射経路 / 線条体 / ドーパトランスポーター / グルタミン酸遊離増大 / ドーパ拮抗薬感受性-高電位活性化Ca^<2+>チャネル電流増大 / 胎仔線条体神経細胞培養 / neuronal cell death / ischemia / 遅発性神経細胞死原因因子 / 圧受容器反射第一次求心性神経伝達物質 / 高電位活性化Ca^<2+>チャネル電流 / Altered DOPA ergic transmission and maintenance of hypertension / cloning
Less
Research Projects
(
6
results)
Co-Researchers
(
8
People)
Project Start Year(Newest)
Project Start Year(Oldest)
ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用
Principal Investigator
三須 良實
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama City University
L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rats
Principal Investigator
GOSHIMA Yoshio
,
三須 良實
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
Yokohama City University
ドーパは神経細胞死の要因か?-線条体培養系,前脳虚血時の役割と新規拮抗薬防御能研索
Principal Investigator
MISU Yoshimi
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
脳虚血時、ドーパは同認識部位-グルタミン酸遊離-神経細胞死の要因か?-萠芽的研究
Principal Investigator
Principal Investigator
古川 信也
Project Period (FY)
1997
Research Category
Grant-in-Aid for Exploratory Research
Research Field
General pharmacology
Research Institution
Yokohama City University
Identification of molecules mediating DOPAergic neurotransmission-Genetic analysis of DOPA-resistant mutants of C.elegans
Principal Investigator
GOSHIMA Yoshio
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Yokohama City University School of Medicine
Studies on DOPA as a Transmitter, searching for its selective binding site, intracellular signal transduction mechanism and receptor cDNA cloning
Principal Investigator
MISU Yoshimi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
General pharmacology
Research Institution
Yokohama City University
# of Projects (Dsc)
# of Projects (Asc)
1.
MIYAMAE Takeaki
(00239435)
# of Collaborated Projects :
6results
# of Collaborated Products :
0results
2.
GOSHIMA Yoshio
(00153750)
# of Collaborated Projects :
6results
# of Collaborated Products :
0results
3.
MISU Yoshimi
(10025687)
# of Collaborated Projects :
4results
# of Collaborated Products :
0results
4.
SASAKI Yukio
(10295511)
# of Collaborated Projects :
2results
# of Collaborated Products :
0results
5.
FUKUSHIMA Nobuyuki
(10254161)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
6.
UEDA Hiroshi
(00145674)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
7.
KANAI Yoshikatsu
(60204533)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
8.
KATSURA Isao
(00107690)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
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