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moriyama kenji  森山 賢治

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MORIYAMA Kenji  森山 賢治

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Researcher Number 00250217
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
2018 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
2008: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
2008: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 … More
2007: 東京都臨床医学総合研究所, 研究員
2004 – 2006: Tokyo Metropolitan Institute of Medical Science, Genome Dynamics Project, Researcher, 東京都臨床医学総合研究所, 研究員
2004: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
2001: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
2000: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
1999 – 2000: 財団法人 東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
1998: 財団法人東京都臨床医学総合研究所, 細胞生物, 研究員
1998: 財団法人生産開発科学研究所, 研究員
1997: (財)東京都臨床医学総合研究所, 細胞生物, 研究員
1997: (財)東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員
1993 – 1997: 財団法人 東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員
1996: 財団法人東京都臨床医学総合研究所, 細胞生物, 研究員
1995: 財団法人東京都臨床医学総合研究所, 生理活性物質研究部門, 研究員
1994 – 1995: 財団法人東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 Less
Review Section/Research Field
Principal Investigator
Cell biology / Basic Section 43020:Structural biochemistry-related / Functional biochemistry / Biological Sciences
Except Principal Investigator
Cell biology / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Functional biochemistry / 内分泌・代謝学 / Biological Sciences / Molecular biology / Functional biochemistry
Keywords
Principal Investigator
アクチン / コフィリン / アクチン結合タンパク質 / デストリン / ストレス / 染色体ドメイン / DNAループ / クライオ電子顕微鏡 / 天然変性領域 / 単粒子解析 … More / 電子顕微鏡 / G4 DNA / グアニン四重鎖 / オリゴマー / タンパク質精製 / Rif1 / EB virus / origin of replication / cell-free system / pre-replicative complex / chromosomal replication / EBウィルス / 複製起点 / 無細胞系 / 複製前複合体 / 染色体複製 / 構造・機能相関 / ゲルゾリン / ADF / 細胞骨格 / 細胞運動 / 温度感受性 / 炭素源飢餓 / 栄養源飢餓 / 出芽酵母 / 脱リン酸化 / リン酸化 / IRES / アンチセンス / 熱ショック / 神経科学 / 海馬 / 小脳 / 免疫組織化学 … More
Except Principal Investigator
コフィリン / oriP / preRC / Epstein Barr Virus / CTLA-4 / Aip1 / cofilin / アクチン / HSP90 / HSP70 / Cdc7キナーゼ / 複製タイミング / 複製起点 / 細胞周期 / 構造生物学 / 構造機能相関 / 多次元NMR / アクチン結合タンパク質 / デストリン / G-quadruplexes / クライオ電顕 / グアニン4重鎖 / シェルタリン / テロメア / クロマチンループ / 単粒子解析 / 電子顕微鏡 / グアニン四重鎖 / オリゴマー / Rif1 / cell cycle / EBNA1 protein / ORC complex / MCM complex / in vitro DNA replication / in vitro DNA複製 / in viitro DNA複製 / Epstein Brrr Virus / EBNAタンパク質 / ORC複合体 / MCM複合体 / in vitro DNA 複製 / autoimmune thyroid disease / TSH receptor / microsatellite / genetic factor / Graves'disease / バセドウ病 / 自己免疫性甲状腺疾患 / TSH受容体 / マイクロサテライト多型 / 遺伝因子 / パセドウ病 / cellular slime mold / growth cone collapse / acceleration of actin filament depolymerization / actrin filament severing / cell movement / actin / AIP 1 / アクチン調節蛋白質 / GFP / 高浸透圧ストレス / AIP1 / 神経突起 / 高浸透圧・ストレス / 収縮 / Cap1 / 細胞性粘菌 / 神経突起縮退 / アクチン繊維脱重合促進 / アクチン繊維切断 / 細胞運動 / Actin / molecular chaperone / cell defense mechanism / stress response / heat shock protein / stress protein / 分子シャペロン / 細胞防御機構 / ストレス応答 / 熱ショック蛋白質 / ストレス蛋白質 / Human disease-model mouse / Apoptosis / Negative selection of T cell / Thymus / Transgenic mouse / 胸線 / 疾患モデル / アポプトーシス / T細胞負の選択 / 胸腺 / トランスジェニックマウス / 構造解析 / 染色体ダイナミクス / リン酸化 / 染色体DNA複製 / 脳発生 / 細胞分裂 / 乗り越えDNA合成 / 減数分裂期組換え / チェックポイント / 染色体DNA複製開始 / MCMタンパク質 / チェックポイント制御 / DNAヘリカーゼ / DNA複製 / 遺伝子の情報発現と複製 / ゲルゾリン Less
  • Research Projects

    (17 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (31 People)
  •  On-grid biochemistry: Structural analyses of G-quadruplex-telomere factor complexes

    • Principal Investigator
      正井 久雄
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Electron microscopic analysis of a G4 DNA-binding protein Rif1, a key organizer of chromosomal domainsPrincipal Investigator

    • Principal Investigator
      MORIYAMA Kenji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Elucidation of DNA replication program in mammalian cells

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Cell-Free Reconstitution of Site-Specific Assembly of Human Pre-Replicative ComplexPrincipal Investigator

    • Principal Investigator
      MORIYAMA Kenji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Enzymatic analyses of eukaryotic chromosomal DNA replication using the Epstein Barr Virus-derived oriP replicon

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  構造・機能相関に基づくアクチン調節タンパク質コフィリンの作用メカニズムの解析Principal Investigator

    • Principal Investigator
      森山 賢治
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Research into the Genetics of Autoimmune Thyroid Disease

    • Principal Investigator
      AKAMIZU Takashi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      内分泌・代謝学
    • Research Institution
      KYOTO UNIVERSITY
  •  Functions of cofilin, an actin-regulating protein

    • Principal Investigator
      IIDA Kazuko, 矢原 一郎
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      The Tokyo Metropolitan Institute of Medical Science
  •  細胞の生存に必要不可欠なコフィリンの活性の解析Principal Investigator

    • Principal Investigator
      森山 賢治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Defense Mechanism of cells from stresses

    • Principal Investigator
      MATSUMOTO Seiji, YAHARA Ichiro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      The Tokyo Metropolitan Institute of Medical Science
  •  NMRによるコフィリン・デストリンの立体構造解析と機能相関

    • Principal Investigator
      畠中 秀樹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  コフィリンのリン酸化部位の同定、及びリン酸化・脱リン酸化による活性制御の解析Principal Investigator

    • Principal Investigator
      森山 賢治
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  NMRによるコフィリン・デストリンの立体構造解析と機関相関

    • Principal Investigator
      畠中 秀樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  コフィリン及びデストリンの動物培養細胞に於ける発現・機能制御システムの構築Principal Investigator

    • Principal Investigator
      森山 賢治
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Analysis of transgenic mice expressing human HSP70

    • Principal Investigator
      ISHII Ai
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      The Tokyo Metropolitan Institute of Medical Science
  •  アクチン結合タンパク質コフィリン及びデストリンの脳内動態の研究Principal Investigator

    • Principal Investigator
      森山 賢治
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

All 2023 2021 2020 2019 2018 2012 Other

All Journal Article Presentation

  • [Journal Article] G-quadruplex binding protein Rif1, a key regulator of replication timing2020

    • Author(s)
      Alavi Sana、Ghadiri Hamed、Dabirmanesh Bahareh、Moriyama Kenji、Khajeh Khosro、Masai Hisao
    • Journal Title

      The Journal of Biochemistry

      Volume: 169 Issue: 1 Pages: 1-14

    • DOI

      10.1093/jb/mvaa128

    • NAID

      40022490610

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21410, KAKENHI-PROJECT-20KK0157, KAKENHI-PROJECT-17H01418, KAKENHI-PROJECT-18K06102, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-19H05277, KAKENHI-PROJECT-20H00463
  • [Journal Article] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities2019

    • Author(s)
      Masai Hisao、Fukatsu Rino、Kakusho Naoko、Kanoh Yutaka、Moriyama Kenji、Ma Yue、Iida Keisuke、Nagasawa Kazuo
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8618-8618

    • DOI

      10.1038/s41598-019-44736-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05349, KAKENHI-PROJECT-18K06072, KAKENHI-PROJECT-18K06102, KAKENHI-PROJECT-19K16082, KAKENHI-PUBLICLY-19H05277, KAKENHI-PUBLICLY-18H04387, KAKENHI-PROJECT-17H01418
  • [Journal Article] Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex(Orc) on oriP of Epstein-Barr virus with purified proteins:stimulation by Cdc6 through its direct interaction with EBNA1.2012

    • Author(s)
      Moriyama K
    • Journal Title

      The Journal of biological chemistry

      Volume: 287 Issue: 28 Pages: 23977-23994

    • DOI

      10.1074/jbc.m112.368456

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20114006, KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23570243, KAKENHI-PROJECT-23657081, KAKENHI-PROJECT-24370071, KAKENHI-PUBLICLY-24114520
  • [Presentation] Association of Rif1 with nuclear membrane is essential for genome-wide replication timing regulation2023

    • Author(s)
      Tomohiro Iguchi, Sayuri Ito, Naoko Kakusho, Rino Fukatsu, Kenji Moriyama, Asako Sawano, Asami Oji, Mikihiro Shibata, Atsushi Miyawaki, Ichiro Hiratani, Hiroyuki Sasanuma and Hisao Masai
    • Organizer
      CSHL Meeting 2023 on Eukaryotic DNA Replication & Genome Maintenance
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0157
  • [Presentation] 染色体動態・維持・機能を決定する多様な因子2023

    • Author(s)
      井口 智弘、伊藤 さゆり、覺正 直子、深津 理乃、森山 賢治、坂上-沢野 朝子、大字 亜沙美、柴田 幹大、宮脇 敦史、平谷 伊智朗、笹沼 博之、正井 久雄
    • Organizer
      第46回 日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20KK0157
  • [Presentation] Mechanisms of membrane association of Rif1 and its role in replication timing regulation2021

    • Author(s)
      Tomohiro Iguchi, Sayuri Ito, Naoko Kokusho, Yutaka Kanoh, Kaho, Takasawa, Kenji Moriyama, Hiroyuki Sasanuma, Hisao Masai.
    • Organizer
      Cold Spring Harbor Laboratory Meeting EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0157
  • [Presentation] 複製タイミング制御因子Rif1の欠失が誘導する2細胞期胚様細胞のZscan4遺伝子エンハンサー構造2019

    • Author(s)
      吉沢直子、森山賢治、正井久雄
    • Organizer
      第42回日本分子生物学会年会 2019.12.6. 福岡国際会議場(4P-0217)
    • Data Source
      KAKENHI-PROJECT-18K06102
  • [Presentation] In search of a universal mode of DNA replication.2019

    • Author(s)
      Masai, H., Kanoh, Y., Tanaka, T., Yoshizawa, N., Ito, S., Moriyama, K., et al.
    • Organizer
      第42回日本分子生物学会年会 2019.12.4. 福岡国際会議場(2PW-04-4)
    • Data Source
      KAKENHI-PROJECT-18K06102
  • [Presentation] Identification of dual G-quadruplex DNA-binding domains in murine Rif1, a key organizer of higher-order chromatin architecture2018

    • Author(s)
      森山賢治、吉沢直子、正井久雄
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K06102
  • [Presentation] DNA-RNA hybrid and G-quadruplex: exploring their biological significance as new genome signatures2018

    • Author(s)
      正井久雄、加納豊、覚正直子、深津理乃、田中卓、吉沢直子、森山賢治、小林駿介、鷺朋子、關口直樹、松本清治、加藤宏幸
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K06102
  • [Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes

    • Author(s)
      Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
    • Organizer
      第86回日本生化学会大会事務局 インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-23247031
  • [Presentation] Rif1: a potential global regulator of DNA replication, DNA repair, and recombination

    • Author(s)
      正井 久雄、山崎 聡志、Lai Mongsing、Foiani Marco、吉沢 直子、加納 豊、松本 清治、森山賢治、覺正 直子、深津 理乃、松嶋 夢叶、河野 暢明、Renard-Guillet Claire
    • Organizer
      第36回(2013年)日本分子生物学会年会,ワークショップ 『DNA二重鎖切断のend-resectionと修復機構の選択・制御』
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2013-12-03 – 2013-12-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-23247031
  • 1.  MATSUMOTO Seiji (40190532)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  MASAI Hisao (40229349)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 3.  YOSHIZAWA Naoko (30344071)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  TAKAI Yuko (90332270)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  ISHII Ai (80124436)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  YAHARA Ichiro (60109957)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  IIDA Kazuko (40151229)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  畠中 秀樹 (00260331)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  SHINMOTO Micie (20216237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MIYATAKE Syouitirou (30239420)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  KANO Yutaka (90450593)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 12.  AIZAWA Hiroyuki (90221704)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  TANAKA Taku (80425686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ODA Masako (50399474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  ITO Sayuri (60462777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  HAYANO Motoshi (30593644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  KAKUSHO Naoko (30599593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  TAYA Choji (90175456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  YONEKAWA Hiromichi (30142110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  ABE Hiroshi (00222662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  AKAMIZU Takashi (20231813)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MORIVAMA Kenji (00301739)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SHIRASAWA Senji (10253535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TSURIMOTO Toshiki (30163885)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SIRAKATA Masaki (70251551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  神田 大輔 (80186618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  井口 智弘 (10783516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 28.  TAMAI Katsuyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  SALE Michele
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  BOWDEN donal
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  飯田 圭介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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