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Ohyama Kyoji  大山 恭司

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OHYAMA Kyoji  大山 恭司

KYOJI Ohyama  大山 恭司

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Researcher Number 00255423
Other IDs
Affiliation (Current) 2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東京医科大学, 医学部, 准教授
2017: 東京医科大学, 大学院医学研究科, 准教授
2013: 長崎大学, 医歯薬学総合研究科, 准教授
2012: 長崎大学, 医歯(薬)学総合研究科, 准教授
2011: 長崎大学, 大学院・医歯薬学総合研究科, 准教授
1994 – 1998: 慶應義塾大学, 医学部, 助手
1995: KEIO UNIV., SCH.OF MEDICINE,DEPT.OF ANATOMY,ASSISTANT, 医学部, 助手
Review Section/Research Field
Principal Investigator
Nerve anatomy/Neuropathology / Basic Section 46020:Anatomy and histopathology of nervous system-related
Except Principal Investigator
Nerve anatomy/Neuropathology / Basic Section 58040:Forensics medicine-related / Basic Section 59040:Nutrition science and health science-related / Neurochemistry/Neuropharmacology / Neuroscience in general / Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
メタボリック症候群 / グリア / ニューロン / 視床下部 / Wnt / Notch / Olig2 / アストロサイト / POMC / NCAM-H … More / Migration / Dopamine neuron / Mesencephalon / phosphacan / 6B4 proteoglycan / L1 / 細胞外基質 / インテグリン / 伸長経路 / 軸索 / 発生 / 中枢神経系 … More
Except Principal Investigator
L1 / マウス / オートファジー / アセチル化 / 老化 / インスリンシグナル / アセチル化修飾 / mTOR / 分子シャペロン / Mdm20 / HDAC6 / development / アンチセンスDNA / NCAM-H / 神経接着分子 / 発生 / 放射状グリア / テネイシン / チロシン水酸化酵素 / DiI / 細胞移動 / ドーパミンニューロン / 中脳黒質 / 心不全 / グリオーシス / 周産期死亡 / 不妊症 / 流産 / 心機能 / 乳幼児突然死症候群 / 睡眠時無呼吸症候群 / 間歇的低酸素 / タンパク質の品質管理 / 老化シグナル / 健康長寿 / シャペロン介在性オートファジー / Akt/PKB / 精子形成 / マイクロRNA / NGS解析 / mTORシグナル / エイコサノイド / 細胞老化 / HSP105 / 炎症性サイトカイン / シャペロン介在生オートファジー / 老化制御因子 / ホメオスタシス / アクチンリモデリング / Rictor / mTORC2 / Akt / 神経老化 / antisense oligo DNA / exo utero surgery / cerebral cortex / rat / ニューロカン / ラット / TAG-1 / 大脳皮質 / 子宮外手術 / phosphacan / whole embryo culture / midbrain / mouse / 中脳 / 全胚培養 / Ll / Radial glia / Tenascin / Tyrosine Hydroxylase / Neuronal Migration / Dopamine Neuron / Substantia Nigra / 共焦点レーザー顕微鏡 / 蛋白凝集 / 微小管 / 可塑性 / 神経 / 蛋白質凝集 / シグナル伝達 / 神経可塑性 / 脳 / 寿命 Less
  • Research Projects

    (10 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (16 People)
  •  視床下部POMCニューロン産生制御機構の解明―メタボリック症候群の予防に向けてPrincipal Investigator

    • Principal Investigator
      大山 恭司
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46020:Anatomy and histopathology of nervous system-related
    • Research Institution
      Tokyo Medical University
  •  Basic research on sleep apnea syndrome and infertility and sudden infant death syndrome

    • Principal Investigator
      前田 秀将
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58040:Forensics medicine-related
    • Research Institution
      Osaka University
  •  The regulation of mTOR signaling and aging by the Yin and Yang effect of acetyl modification

    • Principal Investigator
      Yasuda Kunihiko
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Teikyo University
  •  Regulation of neuronal ageing through the mTOR signaling by acetylation

    • Principal Investigator
      YASUDA KUNIHIKO
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai Gakuin University
      Nagasaki University
  •  Positive and negative regulations of cytoskeletal dynamism and neuronal lifespan

    • Principal Investigator
      MORI Nozomu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Nagasaki University
  •  マウス全胚培養法を用いた中脳黒質ドーパミンニューロンの移動の機序の解析Principal Investigator

    • Principal Investigator
      大山 恭司
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Keio University
  •  Application of the whole embryo culture system to the study on the brain development

    • Principal Investigator
      KAWANO Hitoshi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      KEIO UNIVERSITY
  •  Application of the exo utero surgery to the study on the development of the cerebral cortical

    • Principal Investigator
      KAWAMURA Koki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      KEIO UNIVERSITY
  •  中枢神経発生過程における軸索の伸長経路決定の分子機構Principal Investigator

    • Principal Investigator
      大山 恭司
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Keio University
  •  Confocal laser microscopic study on the mechanism of the migration of dopamine neurons in the mouse mesencephalon.

    • Principal Investigator
      KAWAMURA Koki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      KEIO UNIVERSITY

All 2023 2013 2012 Other

All Journal Article Presentation Other

  • [Journal Article] PSmad3+/Olig2? expression defines a subpopulation of gfap-GFP+/Sox9+ neural progenitors and radial glia-like cells in mouse dentate gyrus through embryonic and postnatal development2023

    • Author(s)
      Ohyama Kyoji、Shinohara Hiroshi M.、Omura Shoichiro、Kawachi Tomomi、Sato Toru、Toda Keiko
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17 Pages: 1-14

    • DOI

      10.3389/fnins.2023.1204012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07233, KAKENHI-PROJECT-23K05995
  • [Journal Article] Mdm20 stimulates PolyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation2013

    • Author(s)
      Yasuda K, Ohyama K, Onga K, Kakizuka A, Mori N
    • Journal Title

      PLoS One

      Volume: 16;8(12)

    • NAID

      120006986747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Journal Article] Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain : Implications for co-operative versus non-co-operative actions of Mdm20 and Nat52012

    • Author(s)
      Ohyama K, Yasuda K, Onga K, Kakizuka A, Mori N
    • Journal Title

      Gene Expr Patterns

      Volume: 12 Pages: 36-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] 視床下部POMCニューロンの発生・新生と環境応答2023

    • Author(s)
      大山恭司、嘉和知朋美、新井優樹、小川文寧、金城ありさ、中村剛、高橋宗春、前田秀将
    • Organizer
      第44回基礎老化学会
    • Data Source
      KAKENHI-PROJECT-23K05995
  • [Presentation] Control of POMC Neurogenesis in the Hypothalamus2023

    • Author(s)
      Kyoji Ohyama
    • Organizer
      The 40th Spring Conference of the Korean Society for Gerontology & Korea-Japan Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K05995
  • [Presentation] マウス海馬歯状回 Olig2 発現アストロサイトの同定2023

    • Author(s)
      大村捷一郎、小川莉奈、杉本大貴 、嘉和知朋美、篠原広志、小川文寧、新井優樹、高橋宗春、前田秀将、大山恭司
    • Organizer
      第29回海馬と高次脳機能学会
    • Data Source
      KAKENHI-PROJECT-23K05995
  • [Presentation] SHH and NOTCH regulate SOX9+ progenitors to govern arcuate POMC neurogenesis2023

    • Author(s)
      Kyoji Ohyama, Elsie Place, Liz Manning, Don Won Kim, Arisa Kinjo, Go Nakamura
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-23K05995
  • [Presentation] An in vitro aging model of long-term cultured hippocampal neurons2013

    • Author(s)
      Okamoto A., Taguchi H., Onga K., Ohyama K., and Mori N
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] 神経保護因子BDNFによるシグナルアダプターN-Shc蛋白質(リン酸化型)の海馬神経細胞内局在の変化2013

    • Author(s)
      大山恭司、岡本愛子、森望
    • Organizer
      第28回日本老年学会総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] 初代培養神経細胞におけるHDAC6によるmTORを介したオートファジー誘導について2013

    • Author(s)
      安田邦彦、大山恭司、田口祥身、森望
    • Organizer
      日本基礎老化学会第36回大会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] Mdm20, an auxiliary subunit of the N-terminal acetyltransferase complex NatB, involves in polyQ aggregate clearance2013

    • Author(s)
      Yasuda K., Ohyama K. and Mori N
    • Organizer
      The 20th IAGG world congress of gerontology and geriatrics
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] Ageing-dependent TGF beta1 signalling in the neuroprotection against an oxidative stress2013

    • Author(s)
      Ohyama K., Yasuda K., Onga K. and Mori N
    • Organizer
      The 20th IAGG world congress of gerontology and geriatrics
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] Ageing-dependent adaptive response of primary hippocampal neurons to an oxidative stress by TGF beta12013

    • Author(s)
      Ohyama K., Yasuda K., Onga K., and Mori N
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] N-アセチル化制御関連分子Mdm20によるAktのリン酸化制御及びオートファジーを介したpolyQタンパク質排除機構2012

    • Author(s)
      安田邦彦、大山恭司、大神和子、垣塚彰、森望
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] Ageing-Dependent Tgf Beta1 Signalling in the Neuroprotection Against an Oxidative Stress.

    • Author(s)
      Ohyama K, Yasuda K, Onga K, Mori N
    • Organizer
      第20回国際老年学会
    • Place of Presentation
      ソウル COEX国際会議場(韓国)
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] Age-Dependent Adaptive Response of Primary Hippocampal Neurons to an Oxidative Stress by TGF beta1.

    • Author(s)
      Ohyama K, Yasuda K, Onga K, Mori N
    • Organizer
      Cold Spring Harbor -Asia symposium: Molecular Basis of Aging and Disease
    • Place of Presentation
      CSH-Asia, Suzhou(中国・蘇州)
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] MDM20, an Auxiliary Subunit of the N-Terminal Acetyltransferase Coplex NATB, Involves in Polyq Aggregate Clearance.

    • Author(s)
      Yasuda K, Ohyama K, Mori N
    • Organizer
      第20回国際老年学会
    • Place of Presentation
      ソウル COEX国際会議場(韓国)
    • Data Source
      KAKENHI-PROJECT-22300121
  • [Presentation] An in vitro aging model of long-term cultured hippocampal neurons

    • Author(s)
      Okamoto A, Taguchi H, Onga K, Ohyama K, Mori N
    • Organizer
      Cold Spring Harbor -Asia symposium: Molecular Basis of Aging and Disease
    • Place of Presentation
      CSH-Asia, Suzhou(中国・蘇州)
    • Data Source
      KAKENHI-PROJECT-22300121
  • []

  • []

  • 1.  KUNIHIKO Yasuda (50278446)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 2.  KAWAMURA Koki (40048286)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KAWANO Hitoshi (20161341)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  NOGAMI Haruo (30119838)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MORI Nozomu (00130394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 6.  TAKEUCHI Kosei (90206946)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MASAHIKO Sibazaki (20445109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SHO Kakizawa (40291059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YOKO Hiraishi-yamaguchi (50311345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAGATA Kazuhiro (50127114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NAKAYAMA Yuji (10280918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SAITO Yohei (90411032)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  前田 秀将 (60407963)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  細道 純 (00420258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  高橋 宗春 (30313125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  篠原 広志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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