KUBO Hitoshi 久保均

Researcher Number	00325292
Other IDs
Affiliation *help	2016 – 2017 : 福島県立医科大学, ふくしま国際医療科学センター, 教授 2016 – 2017 : 福島県立医科大学, 公私立大学の部局等, 教授 2017 : 福島県立医科大学, 新医療系学部設立準備室, 教授 2016 : 福島県立医科大学, 先端臨床研究センター, 教授 2015 – 2016 : 福島県立医科大学, 公私立大学の部局等, 准教授 … More
Review Section/Research Field	Principal Investigator Radiation science / Medical Physics/Radiological Technology / Medical Physics and Radiological Technology / Radiation science Except Principal Investigator Radiation science / Orthopaedic surgery / Thoracic surgery / Biomedical engineering and related fields
Keywords	Principal Investigator 代謝物 / 分子イメージング / 定量化 / マウス / 造影剤 / ダイナミック測定 / 無麻酔 / 超変極 / 超高磁場磁気共鳴装置 / 陽電子放出断層撮影 … More Except Principal Investigator MRS / NAA / MRI / GABA / PET / PET/MR / MEGA-PRESS / SPECT / 脳梗塞 / バイオマーカー / 骨格筋 / IVIM法 / 3T MRI / 神経筋疾患 / α線 / PET定量 / 代謝 / stroke / preclinical animal model / バイオマーカ / シスプラチン / At-211 / 核医学 / glutamate / infarction / 神経科学 / hemorrahge / 内科 / 内照射 / 脳 / 体動補正 / 3 Tesla / 消化器癌 / 筋・神経病学 / アルツハイマー病 / CXCR4 / 骨格筋マルチバラメトリックイメージング / ポジトロン放出断層法（PET） / 骨格筋MRI / 脳灌流 / glucose / 標的アイソトープ治療 / 13C / 拡散強調像 / 危険因子 / 同所性移植 / neurotrasmitter / がん幹細胞 / pyruvate / 脳卒中 / 一過性脳虚血発作 / Lu-177 / RI内用療法 / Dixon法 / whole-body MRI / 受容体占拠率 / MOCO / 脳・神経 / 肺癌 / 核磁気共鳴スペクトロスコピー（MRS) / 薬理学 / ASL法 / 定量評価 / 大腸癌 / PET/CT / 末梢神経疾患 / 血栓溶解療法 / MR spectroscopy / 放射線 / 内照射療法 / 減弱補正 / UTE法 / 運動 / T2*-WI / Glutamate Less

Integrated multimodal imaging of brain and muscle activities with PET/MROngoing
- Principal Investigator
  
  田代学
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Challenging Research (Exploratory)
- Research Field
  
  Biomedical engineering and related fields
- Research Institution
  Tohoku University
PETとMRSの融合による新しいヒト脳内薬物濃度・受容体占拠率測定法の開発Ongoing
- Principal Investigator
  
  田代学
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
がん幹細胞及びがん細胞を標的とするα線放出核種を用いた膵がんの新規治療法開発Ongoing
- Principal Investigator
  
  織内昇
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
進行消化器癌に対するα線核種内照射療法による治療戦略の確立Ongoing
- Principal Investigator
  
  絹谷清剛
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Radiation science
- Research Institution
  Kanazawa University
同時収集型PET/MRI装置による認知症分子病態診断の高度化Ongoing
- Principal Investigator
  
  伊藤浩
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
末梢神経疾患における骨格筋マルチパラメトリックイメージング法の臨床応用の開発Ongoing
- Principal Investigator
  
  松田希
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Fukushima Medical University
癌の個別化医療に資するマルチモーダルセラノスティクストレーサーの臨床応用法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  久保均
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical Physics and Radiological Technology
- Research Institution
  Fukushima Medical University
PET/MRを利用したFDGによる認知症診断精度の向上Ongoing
- Principal Investigator
  
  南部武幸
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
System of measuring anti-cancer effect of orthotopic lung cancer transplantation mouse models using small animal PET/CT.
- Principal Investigator
  
  KONDO Kazuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  The University of Tokushima
Development of quantitative functional evaluation system for small animals using malti-modal imaging systemPrincipal Investigator
- Principal Investigator
  
  KUBO Hitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical Physics/Radiological Technology
- Research Institution
  Fukushima Medical University
  The University of Tokushima
Biomarker using 3TMRI for application of rtPA therapy in patients with brain infarction
- Principal Investigator
  
  HARADA Masahumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Evaluation of new clinical biomarkers of carbon isotope using high field MR equipment.Principal Investigator
- Principal Investigator
  
  KUBO Hitoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Clinical index and development of the method to evaluate dynamic cerebral function using multinuclear high field MRI
- Principal Investigator
  
  HARADA Masafumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
高磁場の利点を活用した新たな乳がんコントラスト画像の開発Principal Investigator
- Principal Investigator
  
  久保均
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Visualization of Molecular Mechanism of Brain Function and Neurological Disease Using High Magnetic Field MRI
- Principal Investigator
  
  HARADA Masafumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
超高磁場臨床用MR装置を用いたダイナミック代謝物測定による脳機能検査法の検討Principal Investigator
- Principal Investigator
  
  久保均
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
脳腫瘍性疾患の客観的画像診断及び治療効果判定のための定量的画像診断法の構築Principal Investigator
- Principal Investigator
  
  久保均
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima

All 2016 2014 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] 核医学機器の進歩　PET/MRIの有用性と技術的展望2016
- Author(s)
  伊藤　浩、石井士朗、南部武幸、久保　均、宮嶋正之、関野啓史、黒岩大地、末永博紀、菅原茂耕、長谷川　靖、橋本直人、織内　昇
- Journal Title
  
  Rad Fan
  
  Volume : 14 Pages : 28-30
- Data Source
  KAKENHI-PROJECT-16K10356
[Journal Article] Optimized workflow and imaging protocols for whole-body oncologic PET/MRI2016
- Author(s)
  Ishii S, Hara T, Nanbu T, Suenaga H, Sugawara S, Kuroiwa D, Sekino H, Miyajima M, Kubo H, Oriuchi N, Ito H
- Journal Title
  
  Jpn J Radiol
  
  Volume : 34 Pages : 754-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10356
[Journal Article] The impact of self-shielded cyclotron operation on small-animal PET/CT equipment installed nearby, on the floor just above2014
- Author(s)
  Kubo H, Otani T, Otsuka H, Harada M.
- Journal Title
  
  Journal of Medical Investiagtion
  
  Volume : 61(1.2) Pages : 46-52
- Data Source
  KAKENHI-PROJECT-23602009
[Journal Article] The impact of self-shielded cyclotron operation on small animal PEt/CT equipment installed neaby, on the floor just above.2014
- Author(s)
  Hitoshi Kubo, Tamaki Otani, Hideki Otsuka, Masafumi Harada
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume : Vol. 61 No. 1, 2 Pages : 46-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23602009
[Journal Article] Non-invasive monitoring of anticancer effects of cisplatin on lung cancer in an orthotopic SCID mouse model using [18F] FDG PET-CT2014
- Author(s)
  Mokhtar M, Kondo K, Takizawa H, Ohtani T, Otsuka H, Kubo H, Kajiura K, Nakagawa Y, Kawakami Y, Yoshida M, Fujino H, Sakiyama S, Tangoku A.
- Journal Title
  
  ONCOLOGY REPORTS
  
  Volume : 31 Pages : 2007-2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659634
[Journal Article] 13C-NMR測定による代謝情報可視化の試み2010
- Author(s)
  久保均, 原田雅史, 前澤博, 阿部孝政
- Journal Title
  
  放射線生物研究 44(4)
  
  Pages : 447-459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591445
[Journal Article] Selection of endogenous 13C substrates for observation of intracellular metabolism using the dynamic nuclear polarization technique.2010
- Author(s)
  Harada M, Kubo H, Abe T, Maezawa H, Otsuka H.
- Journal Title
  
  Jpn J Radiol. 28(2)
  
  Pages : 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591445
[Journal Article] 基礎から臨床へ,MRを用いた代謝機能可視化の最前線2008
- Author(s)
  久保均, 原田雅史, 阿部孝政, 西谷弘
- Journal Title
  
  四国医学雑誌 64(5,6)
  
  Pages : 170-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591445
[Journal Article] 高磁場多核種MR spectroscopyと安定同位体標識化合物の臨床応用2008
- Author(s)
  原田雅史, 久保均, 西谷弘
- Journal Title
  
  日本安定同位体・生体ガス医学応用学会雑誌 vol.1
  
  Pages : 39-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390321
[Journal Article] Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulated of a subgroup of absessive-compulsive disorder patients2007
- Author(s)
  S. Sumitani, M. Harada, H. Kubo, T. Ohmori
- Journal Title
  
  Psychitry Research 154
  
  Pages : 85-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390321
[Journal Article] High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-tesla clinical MRI instrument
- Author(s)
  M. Taki, M. Harada, K. Mori, H. Kubo, A. Nose, T. Matsuda, H. Nishitani
- Journal Title
  
  NeuroImage (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390321
[Presentation] 3D Maximum A Posteriori Reconstruction Method Improves Robustness and Precision of Myocardial Infarct Size Evaluation in Mice Using Technetium-99m Tetrofosmin SPECT/CT2016
- Author(s)
  Kubo H, Shimizu T, Suzuki S, Ito H, Takenoshita S
- Organizer
  Society of Nuclear Medicine and Molecular Imaging
- Place of Presentation
  San Diego, Ca, USA
- Year and Date
  2016-06-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08698
[Presentation] 超偏極13Cピルビン酸を用いた乳がん細胞における乳酸脱水素酵素活性度の評価2010
- Author(s)
  久保均, 原田雅史, 阿部孝政, 前澤博
- Organizer
  第38回日本磁気共鳴医学会大会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-20591445
[Presentation] MRSを用いた代謝機能の定量評価と画像化2010
- Author(s)
  久保均, 原田雅史, 西谷弘
- Organizer
  日本機械学会第22回バイオエンジニアリング講演会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591445
[Presentation] 超偏極13Cピルビン酸を用いた5FUによる乳がん細胞での代謝変化の検出2009
- Author(s)
  久保均, 原田雅史, 阿部孝政, 前澤博, 西谷弘
- Organizer
  第37回日本磁気共鳴医学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591445
[Presentation] J-Difference editing method to evaluate GABA may reveal the mechanism of ACTH therapy for infantile spasms as a useful predict biomarker2009
- Author(s)
  A. Nose, M. Harada, H. Kubo, K. Mori, T. Matsuda, H. Nishitani
- Organizer
  17th ISMRM
- Place of Presentation
  Hawaii
- Year and Date
  2009-04-21
- Data Source
  KAKENHI-PROJECT-19390321
[Presentation] ROC comparison between diffusion-weighted MR and PET/CT imaging to detect lymphnode metastasis from gastrointestinal cnacer2008
- Author(s)
  H. Kubo, M. harada, T. Goto, M. Ikeguchi, M. Takeuchi, H. Nishitani
- Organizer
  16th ISMRM
- Place of Presentation
  Toronto
- Year and Date
  2008-05-06
- Data Source
  KAKENHI-PROJECT-19390321
[Presentation] ISISを用いたlocalized 13C-MRSの基礎的検討2008
- Author(s)
  久保均, 原田雅史, 松田豪, 西谷弘
- Organizer
  第36回日本磁気共鳴医学会大会
- Place of Presentation
  旭川
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19390321
[Presentation] 臨床用3 Tesla ASTによる13C標識glucoseの脳内代謝の観察2008
- Author(s)
  原田雅史, 久保均, 松田豪, 大塚秀樹, 西谷弘
- Organizer
  第36回日本磁気共鳴医学会大会
- Place of Presentation
  旭川
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19390321
[Presentation] Reproducibility of GABA quantification in the brain and the difference of GABA concentration by female genital cycle measured by MEGA-PRESS using clinical 3T MRI apparatus2008
- Author(s)
  M. Harada, H. Kubo, N. Morita, H. Nishitani, T. Matsuda
- Organizer
  16th ISMRM
- Place of Presentation
  Toronto
- Year and Date
  2008-05-05
- Data Source
  KAKENHI-PROJECT-19390321

1. HARADA Masafumi (20228654)

# of Collaborated Projects : 5results

# of Collaborated Products : 16results
2. 伊藤浩 (20360357)

# of Collaborated Projects : 5results

# of Collaborated Products : 2results
3. KAJI Ryuji (00214304)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
4. 富永英之 (00393348)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. OHMORI Tetsuro (00221135)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
6. KANAMASTU Tomoyuki (30104201)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. 田代学 (00333477)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. 渡部浩司 (40280820)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. 織内昇 (40292586)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. NAGAHIRO Shinji (60145315)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KONDO Kazuya (10263815)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
12. NAKAGAWA Yasushi (80380103)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
13. TAKIZAWA Hiromitsu (90332816)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
14. UENO Syuuichi (80232768)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 佐々木真理 (80205864)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 大島康宏 (00588676)

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17. 石岡典子 (30354963)

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18. 趙松吉 (80374239)

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19. 南部武幸 (60706662)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 絹谷清剛 (20281024)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 萱野大樹 (10547152)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. 鷲山幸信 (80313675)

# of Collaborated Projects : 1results

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23. 小川数馬 (30347471)

# of Collaborated Projects : 1results

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24. 村山敏典 (30378765)

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25. 吉村健一 (30415517)

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26. 今井康人 (60720878)

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27. 栗林義和 (40756186)

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28. 稲野彰洋 (30437933)

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29. 若林大志 (60622818)

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30. 稲木杏吏 (40645131)

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31. 藤本敏彦 (00229048)

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32. 村上丈伸 (00403428)

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33. 松田希 (90726457)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KUBO Hitoshi 久保 均

Research Projects

Research Products

Co-Researchers

Integrated multimodal imaging of brain and muscle activities with PET/MROngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PETとMRSの融合による新しいヒト脳内薬物濃度・受容体占拠率測定法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん幹細胞及びがん細胞を標的とするα線放出核種を用いた膵がんの新規治療法開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

進行消化器癌に対するα線核種内照射療法による治療戦略の確立Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

同時収集型PET/MRI装置による認知症分子病態診断の高度化Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

末梢神経疾患における骨格筋マルチパラメトリックイメージング法の臨床応用の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌の個別化医療に資するマルチモーダルセラノスティクストレーサーの臨床応用法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PET/MRを利用したFDGによる認知症診断精度の向上Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

System of measuring anti-cancer effect of orthotopic lung cancer transplantation mouse models using small animal PET/CT.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of quantitative functional evaluation system for small animals using malti-modal imaging systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biomarker using 3TMRI for application of rtPA therapy in patients with brain infarction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of new clinical biomarkers of carbon isotope using high field MR equipment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical index and development of the method to evaluate dynamic cerebral function using multinuclear high field MRI

Principal Investigator

Project Period (FY)

Research Category

KUBO Hitoshi 久保均

[Journal Article] 核医学機器の進歩　PET/MRIの有用性と技術的展望2016