Natsume Toru 夏目徹

… Alternative Names

NATSUME Tohru 夏目徹

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Researcher Number	00357683
Affiliation (Current)	2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 首席研究員
Affiliation (based on the past Project Information) *help	2017 – 2018: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究センター長 2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究センター長 2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 2016: 国立研究開発法人産業技術総合研究所, 創薬プロファイリング研究センター, センター長 2015 – 2016: 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, センター長 … More 2015 – 2016: 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究センター長 2014: 産業技術総合研究所, 創薬分子プロファイリング研究センター, センター長 2013 – 2014: 独立行政法人産業技術総合研究所, 創薬分子プロファイリング研究センター, センター長 2013 – 2014: 独立行政法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究センター長 2012: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 研究チーム長 2012: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 研究員 2009: 産業技術総合研究所, 生物情報解析研究センター, チームリーダー 2008 – 2009: National Institute of Advanced Industrial Science and Technology, バイオメディシナル情報研究センター, 研究チーム長 2007: 独立行政怯人産業技術総合研究所, 生物情報解析研究センター, チームリーダー 2007: National Institute of Advanced Industrial Science and Technology, 独立行政法人産業技術総合研究所・バイオメディシナル情報研究センター, 研究チーム長 2005 – 2006: 独立行政法人産業技術総合研究所, 生物情報解析研究センター, 研究チーム長 2005 – 2006: 独立行政法人産業技術総合研究所, 生物情報解析研究センター・タンパク質ネットワーク解析チーム, チームリーダー Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences Except Principal Investigator Virology / Biological Sciences / General medical chemistry / Biological Sciences
Keywords	Principal Investigator 質量分析 / プロテオミクス / miR-199a / YBX1 / LC-MSMS / LC-MS/MS、 / SWI/SNF複合体 / 定量プロテオミクス / ネットワーク解析 / NS1 … More / LC-MS/MS / HSV-1 / 遺伝子制御ネットワーク / ゲノム / 遺伝子抑制ネットワーク / ゴルジ装置 / ウイルス複製 / 新生タンパク質 / TNF-α / miRNA / HSV-1ウイルス / インフルエンザウイルス / 宿主細胞コンピテンシー / 安定同位体ラベル / Erkイフェクター / 古典的MAPキナーゼカスケ / ダイレクトナノLC / マップキナーゼカスケード / タンパク質問相互作用 / プロテミクス / Erk / シグナル伝達 / マップキナーゼカスケー / 動態解析 / タンパク質ネットワーク解析 / タンパク質間相互作 … More Except Principal Investigator 感染症 / ウイルス / 炎症 / 気道上皮細胞 / サイトカイン / 気道上皮組織 / 炎症応答 / インフルエンザウイルス / ポストゲノム / プロテオミクス / 数理科学 / 感染防御 / 共同研究インターンシップ / 許容性 / 宿主特異性 / 病原性発現 / 感染コンピテンシー / オミックス解析 / 数理科学解析 / 構造解析 / 自然免疫 / コンピテンシー / 宿主因子 / 神経科学 / シグナル伝達 / 神経筋シナプス / 細胞内シグナル伝達 / 腎 / 蛋白質間相互作用 / PDZタンパク質 / 上皮輸送 / 生体膜 / 複合体 / トランスポーター / 膜輸送 Less

Respiratory epithelium-specific inflammatory response against influenza virus infection
- Principal Investigator
  
  Kawaguchi Atsushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  University of Tsukuba
Molecular basis of host cell competency in virus infection
- Principal Investigator
  
  NAGATA Kyosuke
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Understanding the virus-host network by post genome analysisPrincipal Investigator
- Principal Investigator
  
  Natsume Tohru
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Molecular signaling in neuromuscular synaptogenesis and myasthenia
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Quantitation analysis of pathway network analysisPrincipal Investigator
- Principal Investigator
  
  NATSUME Tohru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Organic solute transportsomes: their molecular assembly and functional significance
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyorin University

All 2018 2017 2016 2015 2014 2013 2012 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 明日を拓く新次元プロテオミクス超々高感度質量分析への道のり2009
- Author(s)
  夏目徹
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-17017042
[Book] ストゲノム時代のタンパク質科学2006
- Author(s)
  夏目徹
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17017042
[Book] ゲノムから生命システムへ2005
- Author(s)
  夏目徹
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma2018
- Author(s)
  Kim Yunjung、Shiba-Ishii Aya、Nakagawa Tomoki、Iemura Shun-ichiro、Natsume Tohru、Nakano Noriyuki、Matsuoka Ryota、Sakashita Shingo、Lee SangJoon、Kawaguchi Atsushi、Sato Yukio、Noguchi Masayuki
- Journal Title
  
  Oncogene
  
  Volume: 37 Issue: 40 Pages: 5387-5402
- DOI
  10.1038/s41388-018-0342-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05192, KAKENHI-PROJECT-17K15634
[Journal Article] A large-scale targeted proteomics assay resource based on an in vitro human proteome.2017
- Author(s)
  Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI.
- Journal Title
  
  Nat Methods
  
  Volume: 14 Issue: 3 Pages: 251-258
- DOI
  10.1038/nmeth.4116
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01407, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14612, KAKENHI-PROJECT-16K14664, KAKENHI-PUBLICLY-17H05625
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017
- Author(s)
  Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 484 Issue: 3 Pages: 522-528
- DOI
  10.1016/j.bbrc.2017.01.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.2017
- Author(s)
  Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S.
- Journal Title
  
  J Biol Chem
  
  Volume: 292(10) Issue: 10 Pages: 4099-4112
- DOI
  10.1074/jbc.m116.769109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-26460479
[Journal Article] Robotic crowd biology with Maholo LabDroids.2017
- Author(s)
  Yachie N; Robotic Biology Consortium (inc. Masaki Matsumoto)., Natsume T.
- Journal Title
  
  Nature Biotechnology
  
  Volume: 35 Issue: 4 Pages: 310-312
- DOI
  10.1038/nbt.3758
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01407, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-16J06287, KAKENHI-PROJECT-15K18466, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-25221303, KAKENHI-PROJECT-15K06845
[Journal Article] Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor2016
- Author(s)
  Takashi Kawakami, Koji Ogawa, Tomohisa Hatta, Naoki Goshima, and Tohru Natsume
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 11 Issue: 6 Pages: 1569-77
- DOI
  10.1021/acschembio.5b01014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26102715, KAKENHI-PROJECT-25870146, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H05372, KAKENHI-PROJECT-15KT0071, KAKENHI-PROJECT-15K13751
[Journal Article] Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi2016
- Author(s)
  Fukuzono T, Pastuhov SI, Fukushima O1, Li C, Hattori A, Iemura SI, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.
- Journal Title
  
  Genes　Cells．
  
  Volume: 21(4) Issue: 4 Pages: 311-24
- DOI
  10.1111/gtc.12338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-26640123, KAKENHI-PUBLICLY-15H01375, KAKENHI-PROJECT-15H02388, KAKENHI-PROJECT-26293063, KAKENHI-PROJECT-16K19032
[Journal Article] The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.2016
- Author(s)
  Yamaki, Y., Kagawa, H., Hatta, T., Natsume, T., and Kawahara, H.
- Journal Title
  
  Mol. Cell. Biochem.
  
  Volume: 414 Issue: 1-2 Pages: 1-12
- DOI
  10.1007/s11010-015-2643-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24112007, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-16K14699
[Journal Article] WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.2016
- Author(s)
  Goto T, Matsuzawa J, Iemura SI, Natsume T, Shibuya H．
- Journal Title
  
  FEBS Lett
  
  Volume: 590(9) Issue: 9 Pages: 1291-1303
- DOI
  10.1002/1873-3468.12180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] Functional profiling of asymmetrically-organized human CCT/TRiC chaperonin.2016
- Author(s)
  Araki K, Suenaga A, Kusano H, Tanaka R, Hatta T, Natsume T, Fukui K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 481(3-4) Issue: 3-4 Pages: 232-238
- DOI
  10.1016/j.bbrc.2016.10.120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress.2016
- Author(s)
  Araki K, Kusano H, Sasaki N, Tanaka R, Hatta T, Fukui K, Natsume T.
- Journal Title
  
  J Proteome Res.
  
  Volume: 15(8) Issue: 8 Pages: 2548-59
- DOI
  10.1021/acs.jproteome.6b00087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.2015
- Author(s)
  Takeshi Inoue, Masahiro Morita, Atsushi Hijikata, Yoko Fukuda-Yuzawa, Shungo Adachi, Kyoichi Isono, Tomokatsu Ikawa, Hiroshi Kawamoto, Haruhiko Koseki, Tohru Natsume, Taro Fukao, Osamu Ohara, Tadashi Yamamoto, Tomohiro Kurosaki
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 212 Issue: 9 Pages: 1465-1479
- DOI
  10.1084/jem.20150384
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19127, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-26670472, KAKENHI-PROJECT-26293229
[Journal Article] CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.2015
- Author(s)
  Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, Tsuruta F, Chiba T
- Journal Title
  
  SCIENTIFIC REPORTS
  
  Volume: 5 Issue: 1
- DOI
  10.1038/srep12857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] Purification of noncoding RNA and bound proteins using FLAG peptide-conjugated antisense-oligonucleotides.2015
- Author(s)
  Adachi S, Natsume T
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1262 Pages: 265-274
- DOI
  10.1007/978-1-4939-2253-6_16
- ISBN
  9781493922529, 9781493922536
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.2015
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 10；462（4） Issue: 4 Pages: 383-388
- DOI
  10.1016/j.bbrc.2015.04.144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25290061
[Journal Article] Preemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.2015
- Author(s)
  Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H
- Journal Title
  
  Cell reports
  
  Volume: 13 Issue: 5 Pages: 944-956
- DOI
  10.1016/j.celrep.2015.09.047
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11080, KAKENHI-PUBLICLY-15H01539, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-25253012, KAKENHI-PROJECT-14J07625, KAKENHI-PROJECT-26860641, KAKENHI-PLANNED-26114009
[Journal Article] CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.2015
- Author(s)
  Suzuki T, Kikuguchi C, Sharma S, Sasaki T, Tokumasu M, Adachi S, Natsume T, Kanegae Y, Yamamoto T
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1
- DOI
  10.1038/srep14779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap12015
- Author(s)
  Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.
- Journal Title
  
  Science Signaling.
  
  Volume: 8 Issue: 404 Pages: 404-404
- DOI
  10.1126/scisignal.aad0667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460354, KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-24115007, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-26650011, KAKENHI-PROJECT-26670150
[Journal Article] Artificial human Met agonists based on macrocycle scaffolds2015
- Author(s)
  Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, Matsumoto K, Suga H.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6373-6373
- DOI
  10.1038/ncomms7373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-15K14473, KAKENHI-PROJECT-26220204
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.2015
- Author(s)
  Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, Yamamoto T.
- Journal Title
  
  Cell　Rep
  
  Volume: 13（12） Issue: 12 Pages: 2756-67
- DOI
  10.1016/j.celrep.2015.11.056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.2015
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura SI, Natsume T, Tomida A
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 117(2): Issue: 2 Pages: 500-9
- DOI
  10.1002/jcb.25301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25290061
[Journal Article] Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.2014
- Author(s)
  Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R, Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T, Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou A, Yamamoto T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 22(11): Issue: 11 Pages: 3021-3029
- DOI
  10.1016/j.bmc.2014.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.2014
- Author(s)
  Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N
- Journal Title
  
  Mol Biol Cell.
  
  Volume: 25(8) Issue: 8 Pages: 1327-37
- DOI
  10.1091/mbc.e13-08-0447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PLANNED-25111005
[Journal Article] TBL2 is a novelPERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.2014
- Author(s)
  Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A
- Journal Title
  
  PLOS ONE
  
  Volume: 13:9(11) Issue: 11 Pages: e112761-e112761
- DOI
  10.1371/journal.pone.0112761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-25290061
[Journal Article] ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway2014
- Author(s)
  Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 42 Issue: 15 Pages: 10037-10049
- DOI
  10.1093/nar/gku652
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-26640080, KAKENHI-PUBLICLY-26116721
[Journal Article] PLEIAD/SIMC1/C5orf25, a Novel Autolysis Regulator for a Skeletal-Muscle-Specific Calpain, CAPN3, Scaffolds a CAPN3 Substrate, CTBP12013
- Author(s)
  Ono, Y., Iemura, SI., Novak, S. M., Doi, N., Kitamura, F., Natsume, T., Gregorio, C. C., Sorimachi H
- Journal Title
  
  J. Mol. Biol
  
  Volume: (in press) Issue: 16 Pages: 2955-2972
- DOI
  10.1016/j.jmb.2013.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770139, KAKENHI-PLANNED-24115007
[Journal Article] IQGAP1 regulates nuclear localization of β-Catenin via importin-β5 in Wnt signaling.2013
- Author(s)
  Goto. T, Sato, A., Adachi, S., Iemura, S., Natsume, T. and Shibuya, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 51 Pages: 36351-36360
- DOI
  10.1074/jbc.m113.520528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24590344
[Journal Article] Ero1-alpha and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.2013
- Author(s)
  Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K
- Journal Title
  
  J Cell Biol
  
  Volume: 202(6) Pages: 861-874
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression2013
- Author(s)
  Tsuchiya Y. et al.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 33 Issue: 17 Pages: 3461-3472
- DOI
  10.1128/mcb.01271-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227004, KAKENHI-PLANNED-24115007
[Journal Article] LARP1 specifically recognizes the 3' terminus of poly(A) mRNA.2013
- Author(s)
  Aoki K, Adachi S, Homoto M, Kusano H, Koike K, Natsume T
- Journal Title
  
  Febs Letters
  
  Volume: 587(14) Issue: 14 Pages: 2173-2178
- DOI
  10.1016/j.febslet.2013.05.035
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115007
[Journal Article] Erol-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases2013
- Author(s)
  Kazutaka Araki, Shun-ichiro Iemura, Yukiko Kamiya, David Ron, Koichi Kato, Tohru Natsume, and Kazuhiro Nagata
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 6 Issue: 6 Pages: 861-874
- DOI
  10.1083/jcb.201303027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02049, KAKENHI-ORGANIZER-24115001, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008
[Journal Article] Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic differentiation in myotubes.2013
- Author(s)
  Hoshi T, Tezuka T, Yokoyama K, Iemura S-I, Natsume T, and Yamanashi Y
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 23 Pages: 3749-3754
- DOI
  10.1016/j.febslet.2013.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117511, KAKENHI-PROJECT-23249013, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24121705, KAKENHI-PUBLICLY-25110711, KAKENHI-PUBLICLY-25117708, KAKENHI-PROJECT-25460357
[Journal Article] Dynamic Regulation of Erolα and Peroxiredoxin 4 Localization in the Secretory Pathway2013
- Author(s)
  Taichi Kakihana, Kazutaka Araki, Stefano Vavassori, Shun-ichiro Iemura, Margherita Cortini, Claudio Fagioli, Tohru Natsume, Roberto Sitia and Kazuhiro Nagata
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 41 Pages: 2958629594-2958629594
- DOI
  10.1074/jbc.m113.467845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02049, KAKENHI-PROJECT-12J04142, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24227009
[Journal Article] IQGAP1 functions as a modulator of Dishevelled nuclear localization in Wnt signaling2013
- Author(s)
  Goto, T., Sato, A., Shimizu, M., Adachi, S., Satoh, K., Iemura, S., Natsume, T. and Shibuya, H
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e60865-e60865
- DOI
  10.1371/journal.pone.0060865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390064, KAKENHI-PROJECT-23790358, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-24590344
[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2012
- Author(s)
  Ohte S
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Issue: 3 Pages: 808-814
- DOI
  10.1002/jcb.23408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423, KAKENHI-PROJECT-22791795, KAKENHI-PROJECT-23659732, KAKENHI-PROJECT-24592278, KAKENHI-PLANNED-24115007
[Journal Article] U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells.2012
- Author(s)
  Ideue T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109(15) Issue: 15 Pages: 5693-5698
- DOI
  10.1073/pnas.1200523109
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007
[Journal Article] RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.2012
- Author(s)
  Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.
- Journal Title
  
  Molecular Cell
  
  Volume: 48 Issue: 2 Pages: 182-194
- DOI
  10.1016/j.molcel.2012.07.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700512, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007
[Journal Article] The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP52012
- Author(s)
  Yusuke Sekine, Ryo Hatanaka, Takeshi Watanabe. Naoki Sono, Shun-ichiro Iemura, Tohru Natsume, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, and Hidenori Ichijo
- Journal Title
  
  Molecular Cell
  
  Volume: 48 Issue: 5 Pages: 1-13
- DOI
  10.1016/j.molcel.2012.09.018
- NAID
  120007150217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09553, KAKENHI-PROJECT-20229004, KAKENHI-PLANNED-21117006, KAKENHI-PROJECT-22390347, KAKENHI-PROJECT-23229002, KAKENHI-PROJECT-23659033, KAKENHI-PROJECT-24659027, KAKENHI-PROJECT-24790070, KAKENHI-PUBLICLY-23117510, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007
[Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity.2010
- Author(s)
  Sugiura, Y., K.Araki, S.I.Iemura, T.Natsume, J.Hoseki, K.Nagata
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 7135-7142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010
- Author(s)
  Komatsu, M., H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y.S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, Y. Nishito, S.I. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
- Journal Title
  
  Nat cell biology 12(3)
  
  Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010
- Author(s)
  Komatsu, M., H.Kurokawa, S.Waguri, K.Taguchi, A.Kobayashi, Y.Ichimura, Y.S.Sou, I.Ueno, A.Sakamoto, K.I.Tong, M.Kim, Y.Nishito, S.I.Iemura, T.Natsume, T.Ueno, E.Kominami, H.Motohashi, K.Tanaka, M.Yamamoto
- Journal Title
  
  Nat cell biology. 12
  
  Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.2009
- Author(s)
  Kaneko, T., J.Hamazaki, S.lemura, K.Sasaki, K.Furuyama, T.Natsume, K.Tanaka, S.Murata
- Journal Title
  
  Cell 137
  
  Pages: 914-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009
- Author(s)
  Sagara M、Kawasaki Y、家村俊一郎、夏目徹、Takai Y、秋山徹(東京大学分子細胞生物学研究所)
- Journal Title
  
  Oncogene 28
  
  Pages: 1357-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Promotion of neurite extension by protrudin requires its interaction.2009
- Author(s)
  Saita, S., Shirane, M., Natsume, T., lemura, S., Nakayama, K.
- Journal Title
  
  J Biol Chem. IF=5.58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.2009
- Author(s)
  Nishiyama M、Oshikawa K、Tsukada Y、Nakagawa T、家村俊一郎、夏目徹、Fan Y、Kikuchi A、Skoultchi AI、中山敬一(九州大学生態防御医学研究所)
- Journal Title
  
  Nat Cell Biol 11
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Mys protein regulates protein kinase A activity by interacting with regutatory type 1{alpha} subunit during vertebrate development.2009
- Author(s)
  Kotani, T., S.I.Iemura, T.Natsume, K.Kawakami, M.Yamashita
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 5106-5116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009
- Author(s)
  Kaneko, T., J. Hamazaki, S. Iemura, K. Sasaki, K. Furuyama, T. Natsume, K. Tanaka, S. Murata
- Journal Title
  
  Cell 137(5)
  
  Pages: 914-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Inositol 1, 4, 5-triphosphate receptor-binding protein released with Inositol 1, 4, 5-triphosphate (IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.2009
- Author(s)
  Kiefer H、Mizutani A、家村俊一郎、夏目徹、Ando H、Kuroda Y、御子柴克彦((独)理化学研究所)
- Journal Title
  
  J Biol Chem 284
  
  Pages: 10694-10705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system.2009
- Author(s)
  Tatsumi, K., Y.S.Sou, N.Tada, E.Nakamura, S.I.Iemura, T.Natsume, S.H.Kang, C.H.Chung, M.Kasahara, E.Kominami, M.Yamamoto, K.Tanaka, M.Komatsu
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 5417-5427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy.2009
- Author(s)
  Hosokawa N、Hara T、Kaizuka T、Kishi C、Takamura A、Miura Y、家村俊一郎、夏目徹、Takehana K、Yamada N、Guan JL、Oshiro N、水島昇(東京医科歯科大学私学総合研究科)
- Journal Title
  
  Mol Biol Cell 20
  
  Pages: 1981-1991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis2009
- Author(s)
  Nishiyama, M., K. Oshikawa, Y. Tsukada, T. Nakagawa, S. Iemura, T. Natsume, Y. Fan, A. Kikuchi, A.I. Skoultchi, K.I. Nakayama
- Journal Title
  
  Nat cell biology 11(2)
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Novel In Vitro Protein Fragment Complementation Assay Applicable to High-Throughput Screening in a 1536-Well Format.2009
- Author(s)
  Hashimoto, J., T.Watanabe, T.Seki, S.Karasawa, M.lzumikawa, T.Seki, S.I.lemura, T.Natsume, N.Nomura, N.Goshima, A.Miyawaki, M.Takagi, K.Shin-Ya
- Journal Title
  
  J Biomol Screen. 14
  
  Pages: 970-979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009
- Author(s)
  Ohnishi, E., T.Goto, A.Sato, M.S.Kim, S.I.Iemura, T.Ishitani, T.Natsume, J.Ohnishi, H.Shibuyaup
- Journal Title
  
  Mol cell Biol. 30
  
  Pages: 675-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.2009
- Author(s)
  Patrick, M.S., H.Oda, K.Hayakawa, Y.Sato, K.Eshima, T.Kirikae, S.Iemura, M.Shirai, T.Abe, T.Natsume, T.Sasazuki, H.Suzuki
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 16345-16350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel Grb2 associating protein (Gasp) is critical for positiveselection of thym ocytes,.2009
- Author(s)
  Michael, P., Oda, H., Hayakawa, K., Sato, Y., Eshima, K., Kirikae, T., lemura, S., Shirai, M., Abe, T., Natsume, T., Sasazuki, T., Suzuki, H.
- Journal Title
  
  Proc Natl Acad Sci USA. MS2009-08593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.2009
- Author(s)
  Hosokawa, N., T.Hara, T.Kaizuka, C.Kishi, A.Takamura, Y.Miura, S.lemura, T.Natsume, K.Takehana, N.Yamada, J.L.Guan, N.Oshiro, N.Mizushima
- Journal Title
  
  Molecular biology of the cell 20
  
  Pages: 1981-1991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Atg 101, a novel mammalian autophagy protein interacting with A tg13.2009
- Author(s)
  Hosokawa, N., T.Sasaki, S.I.lemura, T.Natsume, T.Hara, N.Mizushima
- Journal Title
  
  Autophagy 5
  
  Pages: 973-979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Ankyrin repeat domain 28 (ANKRD28), a novel binding partnerof DOCK180, promotes cell migration by regulating focal adhesion formation.2009
- Author(s)
  Tachibana M、Kiyokawa E、Hara S、家村俊一郎、夏目徹、Manabe T、松田道行(京都大学大学院生命科学研究科)
- Journal Title
  
  Exp Cell Res 315
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A parallel affinity purification method for selective isolation of polyubiquitinated proteins.2008
- Author(s)
  伊藤隆司(東京大学)、夏目徹、家村俊一郎、太田一寿(東京大学)、紀藤圭治(東京大学)
- Journal Title
  
  Proteomics 8
  
  Pages: 3004-3007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CAATT/enhancer-binding proteins alpha and delta interact wit h NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.2008
- Author(s)
  Takeshi Tomita(National Institutes of Health)、夏目徹、家村俊一郎、Taketomo Kido(National Institutes of Health)、黒谷玲子(横浜市立大学)、Esta Sterneck(National Institutes of Health)、Charles Vinson(National Institutes of Health)、Shioko Kimura(National Institutes of Health)
- Journal Title
  
  J Biol Chem 283
  
  Pages: 25617-25627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] FIP200, a ULK-interacting protein, is required for autophago some formation in mammalian cells.2008
- Author(s)
  Hara T, Takanlura A, Kishi C, 家村俊一郎, 夏目徹, Guan JL, Mizushima N.
- Journal Title
  
  J Cell Biol. 181
  
  Pages: 497-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex2008
- Author(s)
  Saneyoshi, T., G. Wayman, D. Fortin, M. Davare, N. Hoshi, N. Nozaki, T. Natsume, T.R. Soderling
- Journal Title
  
  Neuron 57(1)
  
  Pages: 94-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells2008
- Author(s)
  Hara, T., A. Takamura, C. Kishi, S. Iemura, T. Natsume, J.L. Guan, N. Mizushima
- Journal Title
  
  The Journal of cell biology 181(3)
  
  Pages: 497-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.2008
- Author(s)
  原重雄(大阪大学)、夏目徹、家村俊一郎、松田道行(京都大学)、清川悦子(京都大学)、Thomas Wassmer(University of Bristol)、Peter J. Cullen (University of Bristol)、日合弘(滋賀県立成人病センター)
- Journal Title
  
  J Biol Chem 19
  
  Pages: 3823-3835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development2007
- Author(s)
  Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 7623-7630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Anchoring of the 26S proteasome to the organellar membrane by FKBP382007
- Author(s)
  Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI.
- Journal Title
  
  Genes Cells 12
  
  Pages: 709-719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007
- Author(s)
  Komatsu, M., S. Waguri, M. Koike, Y.S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, J. Hamazaki, Y. Nishito, S. Iemura, T. Natsume, T. Yanagawa, J. Uwayama, E. Warabi, H. Yoshida, T. Ishii, A. Kobayashi, M. Yamamoto, Z. Yue, Y. Uchiyama, E. Kominami, K. Tanaka
- Journal Title
  
  Cell 131(6)
  
  Pages: 1149-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2007
- Author(s)
  Iioka, H., S. Iemura, T. Natsume, N. Kinoshita
- Journal Title
  
  Nat cell biology 9(7)
  
  Pages: 813-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XRab40 and XCullin5 form aubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee RH, Iioka H, Ohashi M, Iemura S, Natsume T, Kinoshita N.
- Journal Title
  
  EMBO J 26
  
  Pages: 3592-3606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2007
- Author(s)
  Iioka H, Iemura S, Natsume T, Kinoshita N.
- Journal Title
  
  Nat Cell Biol 9
  
  Pages: 813-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nucleo-cytoplasmic shuttling of the zinc finger protein EZI is mediatedby importin-Independent nuclear import and CRMl-independent exportmechanisms2007
- Author(s)
  Saijou E, Itoh T, Kim KW, Iemura SI, Natsume T, Miyajima A.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 32327-32337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee, R.H., H. Iioka, M. Ohashi, S. Iemura, T. Natsume, N. Kinoshita
- Journal Title
  
  The EMBO journal 26(15)
  
  Pages: 3592-3606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Comparative genomic analysis of transcription regulation elements involved in human man kinase g-protein coupling pathway.2006
- Author(s)
  Polouliakh N, Natsume T, Harada H, Fujibuchi W, Horton P
- Journal Title
  
  Bioinform Comput Biol. 4(2)
  
  Pages: 469-482
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Protein phosphatase 6 down-regulates TAKI kinase activation in the IL-1 signaling pathway.2006
- Author(s)
  Kaj ino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J
- Journal Title
  
  J Biol Chem. 281 (52)
  
  Pages: 39891-39896
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes2006
- Author(s)
  Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
- Journal Title
  
  The EMBO journal 25(19)
  
  Pages: 4524-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Cooperation of Multiple Chaperones Required for the Assembly of Mammalian 20S Proteasomes.2006
- Author(s)
  Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S
- Journal Title
  
  Mol Cell. 24 (6)
  
  Pages: 977-984
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] NARF, an Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF).2006
- Author(s)
  Yamada M, Ohnishi J, Ohkawara B, lemura S, Satoh K, Hyodo-Miura J., Kawachi K, Natsume T, Shibuya H
- Journal Title
  
  J Biol Chem. 281 (30)
  
  Pages: 20749-20760
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.2006
- Author(s)
  Hamazaki J, Iemura S, Natsume T, Yashiroda H, Tanaka K, Murata S
- Journal Title
  
  EMBO J 25 (19)
  
  Pages: 4524-4536
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.2006
- Author(s)
  Hyodo-Miura J, Yamamoto TS, Hyodo AC, lemura S, Kusakabe M Nishida E, Natsume T, Ueno N
- Journal Title
  
  Dev Cell. 11 (1)
  
  Pages: 69-79
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy2006
- Author(s)
  Hishiya, A., Iemura, S., Natsume, T., Takayama, S., Ikeda, K., Watanabe, K.
- Journal Title
  
  Embo J 25(3)
  
  Pages: 554-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Shugoshin collaborates with protein phosphatase 2A to protect cohesin2006
- Author(s)
  Kitajima, T.S., Sakuno, T., Ishiguro, K., Iemura, S., Natsume, T., Kawashima, S.A., Watanabe, Y.
- Journal Title
  
  Nature 441(7089)
  
  Pages: 46-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation2006
- Author(s)
  Hyodo-Miura, J., Yamamoto, T.S., Hyodo, A.C., Iemura, S., Kusakabe, M., Nishida, E., Natsume, T., Ueno, N.
- Journal Title
  
  Dev Cell 11(1)
  
  Pages: 69-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Presentation] 分子プロファイリングから展開する創薬加速，2015
- Author(s)
  夏目徹
- Organizer
  第362回CBI学会講演会
- Place of Presentation
  東京大学山上会館（東京）
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] ドラッグ・リポジショニングのための分子プロファイリング2015
- Author(s)
  夏目徹
- Organizer
  BMB2015 （ワークショップ座長講演）
- Place of Presentation
  神戸国際展示場（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] インターオミックスー転写・翻訳・分解全てを俯瞰するハイスループット解析から展開する創薬・診断2015
- Author(s)
  夏目徹
- Organizer
  日本プロテオーム学会2015年会
- Place of Presentation
  くまもと森都心プラザ（熊本）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] 創薬支援のためのプロテオミクス2014
- Author(s)
  夏目　徹
- Organizer
  日本プロテオーム学会2014年会
- Place of Presentation
  つくば国際会議場筑波．つくば市
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] 定量プロテオミクスから展開する分子プロファイリング2014
- Author(s)
  夏目徹
- Organizer
  日本薬学会第134年会特別講演
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] ドラッグ・リプロファイリングから展開するドラッグ・リポジショニング2013
- Author(s)
  夏目徹
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] Pharmacoproteomics: Absolute quantification of protein interactions for drug target identification.2013
- Author(s)
  夏目徹
- Organizer
  KHUPO 13th Annual International Proteomics Conference
- Place of Presentation
  Seoul, Korea
- Year and Date
  2013-03-29
- Invited
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] 定量プロテオミクスから展開する分子プロファイリング2013
- Author(s)
  夏目徹
- Organizer
  新アミノ酸分析研究会第3回学術講演会
- Place of Presentation
  東京大学薬学部講堂
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] Pharmacoproteomics: Absolute quantification of protein interactions for drug target identification2013
- Author(s)
  Natsume T.
- Organizer
  KHUPO 13th Annual International Proteomics Conference
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2013-03-29
- Invited
- Data Source
  KAKENHI-ORGANIZER-24115001
[Presentation] 分子プロファイリングから展開するDR2013
- Author(s)
  夏目徹
- Organizer
  CBI学会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] Purmacoproteomics: Target ID and Target Discovery2012
- Author(s)
  夏目　徹
- Organizer
  ChemBioChem Symosium
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Invited
- Data Source
  KAKENHI-ORGANIZER-24115001
[Presentation] Purmacoproteomics: Target ID and Target Discovery.2012
- Author(s)
  夏目徹
- Organizer
  ChemBioChem Symosium
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Invited
- Data Source
  KAKENHI-PLANNED-24115007
[Presentation] New generation proteomics2009
- Author(s)
  夏目徹
- Organizer
  日本ヒトプロテオーム機構
- Place of Presentation
  北里大学
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-17017042
[Presentation] Systematic Analysis of Protein Interaction Networks Using Human Full Length cDNA.2005
- Author(s)
  夏目徹
- Organizer
  International chemical congress of pacific basin societies
- Place of Presentation
  Hilton Hawaiian Village
- Year and Date
  2005-12-16
- Data Source
  KAKENHI-PROJECT-17017042
[Presentation] Systematic analysis of protein interaction network using human full length cDNA2005
- Author(s)
  夏目徹
- Organizer
  VIth European Symposium of The Protein Society
- Place of Presentation
  Barcelona
- Year and Date
  2005-05-01
- Data Source
  KAKENHI-PROJECT-17017042

1. Iba Hideo (60111449)

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2. IEMURA Shun-ichiro (90356410)

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# of Collaborated Products: 34 results
3. NAKAYAMA hiroshi (80321793)

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4. SHIBUYA Kohji (30261324)

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13. YAMANASHI Yuji (40202387)

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17. MOTOMURA Masakatsu (70244093)

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18. NAGATA Kyosuke (40180492)

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19. Park Sam-Yong (20291932)

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20. Takeyasu Kunio (40135695)

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23. Koyanagi Yoshio (80215417)

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24. INADA Ken_ichi (70246081)

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25. HIROKAWA Takatsugu (20357867)

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26. Kawaguchi Atsushi (90532060)

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27. 脇田隆字 (40280789)

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28. 藤田尚志 (10156870)

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30. 小池智 (30195630)

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31. 佐々木顕 (90211937)

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32. SATO Atsushi

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33. GOTO Toshiyasu

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34. OHTE Satoshi

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35. KADOWAKI Hisae

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36. SUZUKI Takafumi

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37. 井上毅

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38. 小野弥子

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39. 川上隆史

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40. 松本雅記

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41. 伊庭英生

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42. 川原裕之

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43. 鎌田英明

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44. 西頭英起

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46. 林田直樹

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47. 渡邊毅

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Natsume Toru 夏目 徹

NATSUME Tohru 夏目 徹

Research Projects

Research Products

Co-Researchers

Respiratory epithelium-specific inflammatory response against influenza virus infection

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Molecular basis of host cell competency in virus infection

Principal Investigator

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Understanding the virus-host network by post genome analysisPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Molecular signaling in neuromuscular synaptogenesis and myasthenia

Principal Investigator

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Quantitation analysis of pathway network analysisPrincipal Investigator

Principal Investigator

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Research Institution

Organic solute transportsomes: their molecular assembly and functional significance

Principal Investigator

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[Book] 明日を拓く新次元プロテオミクス超々高感度質量分析への道のり2009

Author(s)

Publisher

Data Source

[Book] ストゲノム時代のタンパク質科学2006

Author(s)

Publisher

Data Source

[Book] ゲノムから生命システムへ2005

Author(s)

Publisher

Data Source

[Journal Article] Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A large-scale targeted proteomics assay resource based on an in vitro human proteome.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.2017

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Journal Title

DOI

Data Source

[Journal Article] Robotic crowd biology with Maholo LabDroids.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor2016

Author(s)

Natsume Toru 夏目徹

NATSUME Tohru 夏目徹