KIMURA Tohru 木村徹

… Alternative Names

Researcher Number	30433725
Other IDs
Affiliation (Current)	2022: 杏林大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022: 杏林大学, 医学部, その他 2017 – 2020: 杏林大学, 医学部, 学内講師 2016: 杏林大学, 医学部, 講師 2007 – 2016: Kyorin University, 医学部, 助教 2013: 杏林大学, 医学部, 講師 2007: 杏林大, 医学部, 助手 2006: 杏林大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine / Obstetrics and gynecology / Tumor therapeutics / Basic Section 53040:Nephrology-related / Basic Section 48030:Pharmacology-related Except Principal Investigator General pharmacology / Biological Sciences / Applied pharmacology / Kidney internal medicine / Orthopaedic surgery / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator トランスポーター / シスチン尿症 / タンパク質間相互作用 / 尿酸 / アミノ酸輸送体 / 腎臓 / 極性発現 / 細胞内極性輸送 / 胎盤 / 上皮輸送 … More Except Principal Investigator トランスポーター / 痛風 / 尿酸 / 高尿酸血症 / 薬理学 / 膜輸送 / 複合体 / 生体膜 / 上皮輸送 / PDZタンパク質 / 蛋白質間相互作用 / 腎 / 腎尿細管 / 遺伝子 / 蛋白質 / 有機酸 / 尿酸降下薬 / 尿酸トランスポーター / ABCG2 / 腎外排泄低下型高尿酸血症 / 排泄低下型高尿酸血症 / 産生過剰型高尿酸血症 / 発症年齢 / 腎負荷型高尿酸血症 / 低尿酸血症 / URAT1 / GLUT9 / URATv1 / 短鎖脂肪酸 / 輸送体 / プロテオミクス / 酪酸 / OAT7 / 相互作用 / 有機アニオン / 質量分析 / PDZK1 / プロピオン酸 / PDZ / シグナル伝達 / 亜鉛 / 運動器 / 骨軟骨 / 結合組織 / 亜鉛シグナル / 亜鉛トランスポーター / ZIP7 / ZIP13 / ZIP14 / エーラス・ダンロス症候群 / Neuromedin-U / Nueromedin-U receptor1 / Nueromedin-U receptor2 / Mrgprx-1 / Mrgprx-2 / ILC2 / 2型炎症 / アレルギー性鼻炎 / allergic rhinitis / pathological physiology Less

アミノ酸輸送体を標的とした新規肝嚢胞治療薬の開発Principal Investigator
- Principal Investigator
  
  木村徹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyorin University
Neuromedin Uのアレルギー性鼻炎の病態への関与と画期的な創薬への解析
- Principal Investigator
  
  横井秀格
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyorin University
Therapeutic strategy of ADPKD by anti-amino acid treatmentPrincipal Investigator
- Principal Investigator
  
  木村徹
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kyorin University
Clarification the regulation of short chain fatty acids transport function in the liver.
- Principal Investigator
  
  Fukutomi Toshiyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
inhibition of cancer progression by regulation of amino acid transportersPrincipal Investigator
- Principal Investigator
  
  Kimura Toru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyorin University
How does zinc signal control development and function of musculoskeletal organs?
- Principal Investigator
  
  Fukada Toshiyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokushima Bunri University
  Showa University
Molecular target of urate-lowering drugs: Identification and functional characterization of a novel renal urate transporter URAT2
- Principal Investigator
  
  JUTABHA Promsuk
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Dokkyo Medical University
Identification and analysis of genes influencing serum uric acid levels
- Principal Investigator
  
  ICHIDA Kimiyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of mechanism of the hyperuricemia accompanied by pregnancy induced hypertension (PIH) and multiple pregnancy.Principal Investigator
- Principal Investigator
  
  KIMURA Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyorin University
New drug development for hyperuricemia targeting novel urate efflux transporter URATv1
- Principal Investigator
  
  ANZAI Naohiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Dokkyo Medical University
  Kyorin University
Changing of intracellular trafficking in polarized cells and regulation of serum urate level by the splicing variants of urate transporter URATv1.Principal Investigator
- Principal Investigator
  
  KIMURA Toru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Identification and characterization of cystine transporter interacting proteins for elucidation of cystinuriaPrincipal Investigator
- Principal Investigator
  
  KIMURA Toru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
日本人型シスチン尿症の病因解明の鍵を握る輸送体結合蛋白質の同定とその役割Principal Investigator
- Principal Investigator
  
  木村徹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Organic solute transportsomes: their molecular assembly and functional significance
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyorin University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007

All Journal Article Presentation

[Journal Article] Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells2019
- Author(s)
  Marunaka K, Fujii N, Kimura T, Furuta T, Hasegawa H, Matsunaga T, Endo S, Ikari A
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 9647-9647
- DOI
  10.1038/s41598-019-46250-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08687, KAKENHI-PROJECT-18H02554
[Journal Article] Urate Transport <i>via</i> Paracellular Route across Epithelial Cells2019
- Author(s)
  Kimura T, Tsukada A, Fukutomi T, Ichida K, Ohtsuki S, Sakurai H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 1 Pages: 43-49
- DOI
  10.1248/bpb.b18-00505
- NAID
  130007542224
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08687
[Journal Article] Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporter2017
- Author(s)
  Otsuki H, Kimura T, Yamaga T, Kosaka T, Suehiro JI, Sakurai H.
- Journal Title
  
  Prostate
  
  Volume: 77 Pages: 222-233
- DOI
  10.1002/pros.23263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430121, KAKENHI-PROJECT-15K06879
[Journal Article] Inhibition of epithelial-mesenchymal transition by cetuximab via the EGFR-GEP100-Arf6-AMAP1 pathway in head and neck cancer.2017
- Author(s)
  Matsumoto Y, Sakurai H, Kogashiwa Y, Kimura T, Matsumoto Y, Shionome T, Asano M, Saito K, Kohno N.
- Journal Title
  
  Head Neck.
  
  Volume: 39 Pages: 476-485
- DOI
  10.1002/hed.24626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06879
[Journal Article] Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress2016
- Author(s)
  Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irie, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K., Fukada, T.
- Journal Title
  
  PLoS Genet.
  
  Volume: 12
- DOI
  10.1371/journal.pgen.1006349
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01279, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K11459, KAKENHI-PROJECT-16K08457, KAKENHI-PROJECT-16K15294, KAKENHI-PUBLICLY-16H01369
[Journal Article] Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells.2016
- Author(s)
  Xu M, Sakamoto S, Matsushima J, Kimura T, Ueda T, Mizokami A, Kanai Y, Ichikawa T.
- Journal Title
  
  J Urol.
  
  Volume: 195 Pages: 1588-1597
- DOI
  10.1016/j.juro.2015.11.071
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06879, KAKENHI-PROJECT-25462469, KAKENHI-PROJECT-25293333, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15K15053
[Journal Article] Paracellular Route is the　Major Urate Transport Pathway Across the Blood-Placental Barrier2014
- Author(s)
  Ichiro Uehara, Toru Kimura, Shinji Tanigaki, Toshiyuki Fukutomi, Keiji Sakai, Yoshihiko Shinohara, Kimiyoshi Ichida, Mitsutoshi Iwashita, Hiroyuki Sakurai
- Journal Title
  
  Physiological Reports
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791852
[Journal Article] Paracellular route is the major urate transport pathway across the blood-placental barrier2014
- Author(s)
  Uehara I, Kimura T, Tanigaki S, Fukutomi T, Sakai K, Shinohara Y, Ichida K, Iwashita M, Sakurai H
- Journal Title
  
  Physiol Rep
  
  Volume: 2(5)
- DOI
  10.14814/phy2.12013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791852
[Journal Article] Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells2014
- Author(s)
  Kimura T, Takahashi M, Yan K, Sakurai H
- Journal Title
  
  PLoS One
  
  Volume: 9(1)
- DOI
  10.1371/journal.pone.0084996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791852
[Journal Article] Molecular pathogenic basis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.2014
- Author(s)
  Bin et al.
- Journal Title
  
  EMBO Mol Med
  
  Volume: 6 Pages: 1028-1042
- DOI
  10.15252/emmm.201303809
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461364, KAKENHI-PROJECT-25462874, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-26660086
[Journal Article] 妊娠時における母体・胎児間の尿酸代謝解析2013
- Author(s)
  木村徹、上原一朗、谷垣伸治、岩下光利、安西尚彦、櫻井裕之
- Journal Title
  
  発達腎研究会誌
  
  Volume: 21 Pages: 7-11
- Data Source
  KAKENHI-PROJECT-23791852
[Journal Article] Increased expression of SLC2A9 decreases urate excretion from the kidney.2011
- Author(s)
  Kimura T, Amonpatumrat S, Tsukada A, Fukutomi T, Jutabha P, Thammapratip T, Lee EJ, Ichida K, Anzai N, Sakurai H
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids.
  
  Volume: 30 Pages: 1295-1301
- DOI
  10.1080/15257770.2011.628354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073, KAKENHI-PROJECT-23790952
[Journal Article] 新規ヒト有機酸排出トランスポーターhNPT4 (SLC17A3) の輸送特性2011
- Author(s)
  安西尚彦、Jutabha Promsuk、木村徹、遠藤仁、櫻井裕之
- Journal Title
  
  痛風と核酸代謝
  
  Volume: 35 Pages: 31-37
- NAID
  10029325947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073
[Journal Article] Increased expression of SLC2A9 decreases urate excretion from the kidney2011
- Author(s)
  Kimura T, Anzai N, et al
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids
  
  Volume: Vol.30 Pages: 1295-1301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073
[Journal Article] Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms.2011
- Author(s)
  Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H.
- Journal Title
  
  J Pharmacol Sci. 115
  
  Pages: 249-253
- NAID
  10029892290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms.2010
- Author(s)
  Sakata T, Anzai N, Kimura T, et al.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 113 Pages: 263-266
- NAID
  10029889401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate2010
- Author(s)
  Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 35123-35132
- DOI
  10.1074/jbc.m110.121301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073
[Journal Article] Human sodium-phosphate transporter 4 (hNpT4/SLC17A3) as a commonrenal secretory pathway for drugs and urate.2010
- Author(s)
  Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, et al.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285 Pages: 35123-35132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] Human sodium-phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.2010
- Author(s)
  Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H.
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 35123-35132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] 尿酸トランスポーターURAT1トランスジェニックマウスにおける尿酸の体内動態2010
- Author(s)
  塚田愛、木村徹、Promsuk Jutabha、安西尚彦、市田公美、櫻井裕之
- Journal Title
  
  痛風と核酸代謝 34
  
  Pages: 171-178
- NAID
  10027722204
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] ヒト尿酸トランスポーターURAT1 によるサリチル酸輸送2010
- Author(s)
  大津尚子、安西尚彦、福冨俊之、木村徹、櫻井裕之、遠藤仁
- Journal Title
  
  日腎会誌
  
  Volume: 52 Pages: 499-504
- NAID
  10026409305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073
[Journal Article] System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line.2009
- Author(s)
  Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S, Kanai Y, Kohno N.
- Journal Title
  
  Cancer Lett. 276(1)
  
  Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081016
[Journal Article] 新規尿酸排出トランスポータ-URArv1の尿酸輸送特性の解析2009
- Author(s)
  木村徹、安西尚彦、Promsuk Jutabha、三浦大作、遠藤仁、櫻井裕之
- Journal Title
  
  痛風と核酸代謝 33
  
  Pages: 177-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] 新規尿酸排出トランスポーターURATv1の尿酸輸送特性の解析2009
- Author(s)
  木村徹、安西尚彦、Promsuk Jutabha、三浦大作、遠藤仁、櫻井裕之
- Journal Title
  
  痛風と核酸代謝 33
  
  Pages: 177-182
- NAID
  10025596953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] 腎臓の尿酸トランスポーター:最近の進歩2009
- Author(s)
  安西尚彦、Promsuk Jutabha、木村徹、櫻井裕之
- Journal Title
  
  痛風と核酸代謝 33
  
  Pages: 7-15
- NAID
  10025596817
- Data Source
  KAKENHI-PROJECT-21790819
[Journal Article] System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line2009
- Author(s)
  Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S Kauai Y, Kohn N
- Journal Title
  
  Cancer Lett 276
  
  Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081016
[Journal Article] Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer.2009
- Author(s)
  Yamauchi K, Sakurai H,Kimura T, Wiriyasermkul P, et al.
- Journal Title
  
  Cancer Lett. 276
  
  Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081016
[Journal Article] A novel role of the C-terminus of b^<0, +>AT in the ER-Golgi trafficking of the rBAT-b^<0, +>AT heterodimeric amino acid transporter.2009
- Author(s)
  Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.
- Journal Title
  
  Biochem J. 417
  
  Pages: 441-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081016
[Journal Article] A pathogenic C terminus-truncated polycystin- 2 mutant enhances receptor-activated Ca^<2+> entry via association with TRPC3 and TRPC72009
- Author(s)
  Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 34400-34412
- NAID
  120006334914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081016
[Journal Article] 新規尿酸排出トランスポーターURATv1の尿酸輸送特性の解析2009
- Author(s)
  木村徹
- Journal Title
  
  痛風と核酸代謝 33
  
  Pages: 177-183
- NAID
  10025596953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390073
[Journal Article] novel role of the C-terminus of b 0, + AT in the ER/Golgi trafficking of the rBAT/b 0, + AT heterodimeric amino acid transporter.2009
- Author(s)
  Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.
- Journal Title
  
  Biochem. J. 417
  
  Pages: 441-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790590
[Presentation] Identification of interacting proteins for a liver-specific butyrate transporter OAT72019
- Author(s)
  Toshiyuki Fukutomi, Toru Kimura, Naohiko Anzai, Hiroyuki Sakurai.
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08555
[Presentation] 前立腺癌アンドロゲン受容体高発現細胞株におけるロイシン輸送トランスポータ2015
- Author(s)
  大槻英男、木村徹、山賀貴、末弘淳一、櫻井裕之
- Organizer
  第 132 回日本薬理学会関東部会
- Place of Presentation
  浦安
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-15K06879
[Presentation] 上皮細胞における尿酸のparacellular輸送とclaudinの発現2013
- Author(s)
  木村徹、塚田愛、大槻純男、福冨俊之、市田公美、櫻井裕之
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 上皮細胞における尿酸輸送とclaudinの発現2013
- Author(s)
  木村徹、塚田愛、大槻純男、福冨俊之、市田公美、櫻井裕之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 上皮細胞における尿酸のparacellular輸送2013
- Author(s)
  木村徹、塚田愛、市田公美、櫻井裕之
- Organizer
  第46回日本痛風・核酸代謝学会総会
- Place of Presentation
  新宿
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 上皮細胞における尿酸のparacellular輸送2013
- Author(s)
  木村徹、塚田愛、市田公美、櫻井裕之
- Organizer
  第46回　日本痛風・核酸代謝学会総会
- Place of Presentation
  東京・新宿
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] HPRT欠損症：新たな日本人家系のHPRT1変異とPRPP濃度2013
- Author(s)
  山田裕一, 野村紀子, 山農亜里佐, 山田憲一郎, 木村礼子, 福士大輔, 長谷川弘, 中村真希子, 市田公美, 若松延昭
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591205
[Presentation] Uric acid crosses the placental barrier through paracellular route2012
- Author(s)
  Toru Kimura, Ichiro Uehara, Shinji Tanigaki, Mitsutoshi Iwashita, Hiroyuki Sakurai
- Organizer
  2012 ASCB Annual Meeting
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 腎尿酸トランスポーター遺伝子改変マウスを用いた高尿酸血症発症機序の解明2011
- Author(s)
  安西尚彦、木村徹^1(^1 杏林大・医)
- Organizer
  第54回日本腎臓学会学術総会ワークショップ1 腎疾患・病態の理解を目指すトランスポーター遺伝子改変動物の利用
- Place of Presentation
  横浜
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] 新規ヒト尿酸/有機酸トランスポーターURAT2の分子同定2011
- Author(s)
  安西尚彦,Jutabha P,木村徹,北村健一郎,市田公美
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591205
[Presentation] 尿酸トランスポーターURATv1/GLUT9の組織発現と極性細胞におけるソーティングの解析2011
- Author(s)
  木村徹
- Organizer
  第44回日本痛風・核酸代謝学会総会
- Place of Presentation
  新宿
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] Elucidation of urate transport mechanism by analysis of renal urate transporters' transgenic mice.2011
- Author(s)
  Toru Kimura
- Organizer
  14th International Symposium on Purine and Pyrimidine Metabolism in Man (PP11)
- Place of Presentation
  新宿
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] Urate transport between maternal and umbilical cord blood in the placent2011
- Author(s)
  木村徹、上原一郎、谷垣伸治、岩下光利、安西尚彦、櫻井裕之
- Organizer
  International Joint Meeting of Cellular and Molecular Physiology in Epithelia
- Place of Presentation
  北里大学(白金キャンパス)
- Year and Date
  2011-07-31
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 新規尿酸トランスポーターの分子同定:ヒト尿酸代謝の全貌解明に向けて2011
- Author(s)
  安西尚彦、Jutabha Promsuk、福冨俊之、木村徹、三浦大作^1(^1 兵庫医療大・薬)
- Organizer
  日本薬学会第131 年会一般シンポジウムS18 痛風・高尿酸血症:最近の進歩
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] Urate transport between maternal and umbilical cord blood in the placent2011
- Author(s)
  木村徹、上原一郎、谷垣伸治、岩下光利、安西尚彦、櫻井裕之
- Organizer
  International Joint Meeting of Cellular and Molecular Physiology in Epithelia
- Place of Presentation
  北里大学（白金キャンパス）
- Data Source
  KAKENHI-PROJECT-23791852
[Presentation] 腎臓における有機酸輸送2010
- Author(s)
  安西尚彦、Jutabha Promsuk、木村徹、福冨俊之
- Organizer
  第54回日本薬学会関東支部大会シンポジウム2「トランスポーター研究の最前線」
- Place of Presentation
  八王子
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] 腎臓の有機酸輸送:尿細管管腔側有機酸排出の分子機序2010
- Author(s)
  安西尚彦、Jutabha Promsuk、木村徹、福冨俊之
- Organizer
  トランスポーター研究会第4回九州部会シンポジウム「膜輸送研究の最前線」
- Place of Presentation
  長崎
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] 尿酸輸送体過剰発現マウスを用いた尿酸輸送機構の解析2010
- Author(s)
  木村徹
- Organizer
  第53回日本腎臓学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] Isoform specific tissue distribution of URATv1/GLUT9 and their trafficking in the polarized cells.2010
- Author(s)
  Toru Kimura
- Organizer
  50^<th> The American Society for Cell Biology Annual Meeting
- Place of Presentation
  アメリカフィラデルフィア
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] Isoform specific tissue distribution of URATv1/GLUT9 and their trafficking in the polarized cells.2010
- Author(s)
  Toru Kimura, Anzai Naohiko, Hiroyuki Sakurai
- Organizer
  50^<th> The American Society for Cell Biology Annual Meeting
- Place of Presentation
  アメリカフィラデルフィア
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] 腎尿細管利尿薬分泌経路の分子機序:新規ヒト電位依存性有機酸トランスポーターhOATv1 の同定2010
- Author(s)
  安西尚彦、Promsuk Jutabha、福冨俊之、木村徹、遠藤仁、櫻井裕之
- Organizer
  第122 回日本薬理学会関東部会ミニシンポジウム3 チャネル・トランスポーターの薬理学
- Place of Presentation
  静岡
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] 尿酸輸送機構の解明を目的とした尿酸トランスポーター過剰発現マウスの解析2010
- Author(s)
  木村徹
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21790819
[Presentation] 高尿酸血症の発症機序解明および新規治療薬創製を目指した尿酸輸送体過剰発現マウスの解析2010
- Author(s)
  木村徹、安西尚彦、金井好克^1、櫻井裕之(^1 阪大院・医)
- Organizer
  第2 回FRONT-J スペシャルシンポジウム「腎尿細管トランスポーター:遺伝子改変動物を用いた疾患・病態の理解」
- Place of Presentation
  中央区
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21390073
[Presentation] 有機アニオントランスポーター:腎尿細管上皮輸送における新たな展開2007
- Author(s)
  金井好克, 安西尚彦, 平田拓, 木村徹, 上野剛, 福冨俊之
- Organizer
  第84回日本生理学会大会
- Place of Presentation
  大阪
- Year and Date
  2007-03-22
- Data Source
  KAKENHI-PROJECT-17081016

1. ANZAI Naohiko (70276054)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
2. KANAI Yoshikatsu (60204533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. FUKUTOMI Toshiyuki (30439187)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. JUTABHA Promsuk (90541748)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. ENDOU Hitoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. WEMPE Michael F.

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. NAGAMORI Shushi (90467572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. OHGAKI Ryuichi (20467525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRATA Taku (60372918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. NATSUME Tohru (00357683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. UENO Takeshi (20406979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TANAKA Hidekazu (70273638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. UCHIDA Kohsuke (30168695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KOJIMA Shuichi (60178267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. DOMAE Mariko (20285878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HAYASHI Keitaro (10323106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. YAN Kunimasa (70255389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. MIURA Daisaku (60510873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. KAWAHARA Katsumasa (70134525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ICHIDA Kimiyoshi (80183169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. HOSOYAMADA Makoto (00291659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MATSUO Hirotaka (00528292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAMURA Makiko (80447557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. NAKAMURA Yoshihiro (60415255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. Fukada Toshiyuki (70373363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. 横井秀格 (80317487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 花田礼子 (00343707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TSUKADA Ai

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. AMMONPATUMRAT Sirirat

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. THAMMAPRATIP Thanapol

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. TAEJARERNWIRIYAKUL Ormjai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. JAIYEN Chaliya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. KIMURA Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. SAKAMOTO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. SUEHIRO Junichi

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# of Collaborated Products: 1 results
36. SAKURAI Hiroyuki

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37. 森寿

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# of Collaborated Products: 1 results
38. 佐藤俊朗

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39. 大橋若奈

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40. 美島健二

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41. 入江太朗

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42. 長谷耕二

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43. 市川智彦

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44. 古田巧

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45. 神戸大朋

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# of Collaborated Products: 1 results

KIMURA Tohru 木村 徹

木村 徹 キムラ トオル

Research Projects

Research Products

Co-Researchers

アミノ酸輸送体を標的とした新規肝嚢胞治療薬の開発Principal Investigator

Principal Investigator

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Review Section

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Neuromedin Uのアレルギー性鼻炎の病態への関与と画期的な創薬への解析

Principal Investigator

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Review Section

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Therapeutic strategy of ADPKD by anti-amino acid treatmentPrincipal Investigator

Principal Investigator

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Review Section

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Clarification the regulation of short chain fatty acids transport function in the liver.

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inhibition of cancer progression by regulation of amino acid transportersPrincipal Investigator

Principal Investigator

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How does zinc signal control development and function of musculoskeletal organs?

Principal Investigator

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Molecular target of urate-lowering drugs: Identification and functional characterization of a novel renal urate transporter URAT2

Principal Investigator

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Identification and analysis of genes influencing serum uric acid levels

Principal Investigator

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Elucidation of mechanism of the hyperuricemia accompanied by pregnancy induced hypertension (PIH) and multiple pregnancy.Principal Investigator

Principal Investigator

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New drug development for hyperuricemia targeting novel urate efflux transporter URATv1

Principal Investigator

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Changing of intracellular trafficking in polarized cells and regulation of serum urate level by the splicing variants of urate transporter URATv1.Principal Investigator

Principal Investigator

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Identification and characterization of cystine transporter interacting proteins for elucidation of cystinuriaPrincipal Investigator

Principal Investigator

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Research Institution

日本人型シスチン尿症の病因解明の鍵を握る輸送体結合蛋白質の同定とその役割Principal Investigator

Principal Investigator

Project Period (FY)

KIMURA Tohru 木村徹

木村徹キムラトオル

[Journal Article] Paracellular Route is the　Major Urate Transport Pathway Across the Blood-Placental Barrier2014