Ai Tomohiko 藍智彦

Researcher Number	00570128
Other IDs	https://orcid.org/0000-0003-0376-0227
Affiliation (Current)	2024: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 医学部, 教授 2022 – 2023: 順天堂大学, 医学部, 先任准教授 2018 – 2022: 順天堂大学, 医学部, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 55060:Emergency medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 55060:Emergency medicine-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator iPS細胞 / 機能実験 / 遺伝子検査 / 疾患遺伝子関連 / RBM20 / 拡張型心筋症 / モデル / 遺伝子変異 / 心筋症 / 機能解析 … More / 遺伝子異常 / 神経細胞 / 遺伝子解析 / 症候性 / 性差 / けいれん / 脳疾患 / 心電図 / 遺伝子 / 突然死 / てんかん … More Except Principal Investigator DNAメチル化 / BCL-2 / シングルセル解析 / 急性骨髄性白血病 / 内在性レトロウイルス / 電気的リモデリング / 器質的脳疾患 / 不整脈 / 心電図 / てんかん / 高齢者 / 白血病幹細胞 / バイオマーカー / Single-Cell ATAC-Seq / DNAメチル基転移酵素 / 難治性白血病 / RNA-seq / single cell ATAC-seq / single cell RNA-seq / RNA-seq解析 / メチル化アレイ解析 / 骨髄微小環境 / インターフェロン誘導遺伝子 / DNAメチル化阻害剤 / BCL-2阻害剤 Less

心電図解析によるてんかん患者の発作予後予測に関する検討
- Principal Investigator
  
  森周介
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tokyo Medical and Dental University
難治性白血病の内在性レトロウイルス活性化機序に基づく新規バイオマーカー開発
- Principal Investigator
  
  田部陽子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Juntendo University
臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明Principal Investigator
- Principal Investigator
  
  藍智彦
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
Leukemic stem cell signatures to identify therapeutic targets of elderly acute myeloid leukemia
- Principal Investigator
  
  田部陽子
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Juntendo University
てんかん原因遺伝子の網羅的解析および心電図の診断有用性の検討Principal Investigator
- Principal Investigator
  
  藍智彦
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Juntendo University

All 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] 不整脈2019　遺伝子病としての不整脈：遺伝子診断の光と影2019
- Author(s)
  堀江稔、藍智彦
- Total Pages
  238
- Publisher
  メディカルレビュー
- Data Source
  KAKENHI-PROJECT-18K08900
[Journal Article] Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML2022
- Author(s)
  Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M
- Journal Title
  
  Translational Oncology
  
  Volume: 18 Pages: 101354-101354
- DOI
  10.1016/j.tranon.2022.101354
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-21K06585, KAKENHI-PROJECT-21K07226, KAKENHI-PROJECT-21K20913, KAKENHI-PROJECT-19KK0221, KAKENHI-PROJECT-19H04355
[Journal Article] Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.2022
- Author(s)
  Ozawa J, Ohno S, Melgari D, Wang Q, Fukuyama M, Toyoda F, Makiyama T, Yoshinaga M, Suzuki H, Saitoh A, Ai T, Horie M.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 18984-18984
- DOI
  10.1038/s41598-022-23512-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-21K06781, KAKENHI-PROJECT-21K08135, KAKENHI-PROJECT-22K07840, KAKENHI-PROJECT-22K08179, KAKENHI-PROJECT-21H02888
[Journal Article] Pandora will never regret having opened her box: reappraisal of genes associated with CPVT and SQTS2022
- Author(s)
  Horie M, Ohno S, Ai T.
- Journal Title
  
  Eur Heart J.
  
  Volume: 43 Issue: 15 Pages: 1511-1513
- DOI
  10.1093/eurheartj/ehab794
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08135
[Journal Article] Evidence-Based Assessment of Genes in Dilated Cardiomyopathy2021
- Author(s)
  Jordan E, Peterson L, Ai T, et al.
- Journal Title
  
  Circulation
  
  Volume: 144 Issue: 1 Pages: 7-19
- DOI
  10.1161/circulationaha.120.053033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08135
[Journal Article] Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.2021
- Author(s)
  Saito K, Zhang Q, Yang H, Yamatani K, Ai T, Ruvolo V, Baran N, Cai T, Ma H, Jacamo R, Kuruvilla V, Imoto J, Kinjo S, Ikeo K, Moriya K, Suzuki K, Miida T, Kim YM, Vellano CP, Andreeff M, Marszalek JR, Tabe Y, Konopleva M.
- Journal Title
  
  Blood Adv
  
  Volume: 5 Issue: 20 Pages: 4233-4255
- DOI
  10.1182/bloodadvances.2020003661
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07424, KAKENHI-PROJECT-19K16809, KAKENHI-PROJECT-19KK0221
[Journal Article] Phosphorylation of Lamin A/C at serine 22 modulates Nav 1.5 function2021
- Author(s)
  Olaopa MA, Ai T, Chao B, Xiao X, Vatta M, Habecker BA
- Journal Title
  
  Physiol Rep
  
  Volume: 22 Issue: 22
- DOI
  10.14814/phy2.15121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08135
[Journal Article] Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series2021
- Author(s)
  Atsushi Hori, Tomohiko Ai, Miwa Isshiki, Yumiko Motoi, Kouji Yano, Yoko Tabe, Nobutaka Hattori, Takashi Miida
- Journal Title
  
  Geriatrics
  
  Volume: 6 Issue: 1 Pages: 14-14
- DOI
  10.3390/geriatrics6010014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16532, KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-19K07874
[Journal Article] Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?2021
- Author(s)
  Mori S, Hori A, Turker I, Inaji M, Bello-Pardo E, Miida T, Otomo Y, Ai T
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 10 Issue: 9
- DOI
  10.1161/jaha.120.019778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-20K09341, KAKENHI-PROJECT-20K16532
[Journal Article] Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Nav 1.5 currents in HEK-293 cells2020
- Author(s)
  Turker I, Makiyama T, Ueyama T, Shimizu A, Yamakawa M, Chen PS, Vatta M, Horie M, Ai T
- Journal Title
  
  Pacing Clin Electrophysiol
  
  Volume: 43 Issue: 8 Pages: 838-846
- DOI
  10.1111/pace.13996
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-20K08416
[Journal Article] Variant Interpretation for Dilated Cardiomyopathy: Refinement of the American College of Medical Genetics and Genomics/ClinGen Guidelines for the DCM Precision Medicine Study2020
- Author(s)
  Morales A, Kinnamon DD, Jordan E, Platt J, Vatta M, Dorschner MO, Starkey CA, Mead JO, Ai T, Burke W, Gastier-Foster J, Jarvik GP, Rehm HL, Nickerson DA, Hershberger RE; DCM Precision Medicine study of the DCM Consortium
- Journal Title
  
  Circ Genom Precis Med
  
  Volume: 13 Issue: 2
- DOI
  10.1161/circgen.119.002480
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900
[Patent] アルツハイマー病を標的とした治療2022
- Inventor(s)
  Tomohiko Ai
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-000610
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-18K08900
[Presentation] Biomarkers of clinical resistance to Decitabine and Venetoclax therapy inferred by transcriptome and methylation analyses2022
- Author(s)
  Kotoko Yamatani, Abhishek Maiti, Tatsuro Watanabe, Kaori Saitoh, Kala Hayes, Kanako Kinjo, Kazuho Ikeo, Takashi Miida, Shinya Kimura,Courtney D. DiNardo, Su Xiaoping, Yoko Tabe,Marina Konopleva
- Organizer
  64th American Society of Hematology Annual Meeting and Exposition 2022
- Data Source
  KAKENHI-PROJECT-19KK0221
[Presentation] Diverse mechanisms of resistance to Decitabine and Venetoclax therapy in newly diagnosed and relapsed/refractory AML inferred by transcriptome analysis.2021
- Author(s)
  Kotoko Yamatani, Yoko Tabe, Abhishek Maiti, Tomohiko Ai, Kaori Saitoh, Kazuhiro R. Nitta, Sonoko Kinjo, Kazuho Ikeo, Takashi Miida, Courtney D. DiNardo, Su Xiaoping, Marina Konopleva
- Organizer
  63th American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0221
[Presentation] Phenotypic Architecture of FLNC Variant Carriers in a Dilated Cardiomyopathy Cohort2021
- Author(s)
  Peterson L, Jordan E, Ai T, Vatta M, Mead JO, Kinnamon DD, Hershberger RE
- Organizer
  NSGC 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08135
[Presentation] Phenotypic and genetic profile of SCN5A Variants in Idiopathic Dilated Cardiomyopathy2021
- Author(s)
  Ai T, Jordan E, Peterson L, Vatta M, Hurst N, Kinnamon D, Hershberger R
- Organizer
  Heart Failure Society of America HFSA 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08135
[Presentation] 認知症患者で新たに発見されたCLCN1, RYR2及びDCTN1遺伝子変異：認知症患者における遺伝子検査から得た教訓2020
- Author(s)
  1.堀　敦詞, 藍　智彦, 本井　ゆみ子, 一色　美和, 田部　陽子, 平山　哲, 三井田　孝
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08900
[Presentation] CRISPR Cas9 法による DEPDC5 欠損ヒト iPS 細胞の作製の試み2020
- Author(s)
  堀敦詞，藍智彦，赤松和土，三井田孝
- Organizer
  第60回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08900
[Presentation] The direct interactions with bone marrow microenvronment confer resistance to the inhibition of Oxidative Phosphorylation in AML2020
- Author(s)
  Yoko Tabe, Kaori Saitoh, Kotoko Yamatani, Haeun Yang, Rodrigo Jacamo, Helen Ma, Vivian Ruvolo3, Qi Zhang, Vinitha Kuruvilla, Natalia Baran, Junichi Imoto, Kazuho Ikeo5, Kaori Moriya, Yuko Murakami-Tonami, Koya Suzuki, Takashi Miida, Michael Andreeff, Christopher P. Vellano, Joseph R. Marszalek, Marina Konopleva
- Organizer
  American Society of Hematology Annual Meeting
- Data Source
  KAKENHI-PROJECT-19KK0221
[Presentation] Variants In ARVC-Associated Genes Contribute To The Genetic Complexity Of Idiopathic DCM: An Initial Analysis From The DCM Precision Medicine Study2020
- Author(s)
  Elizabeth Jordan, Daniel D. Kinnamon, Jonathan O. Mead, Garrie Haas, Tomohiko Ai, Laiken Peterson, Ray E. Hershberger
- Organizer
  Heart Rhythm 2020 Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900
[Presentation] BCL2A1: a novel target in refractory acute myeloid leukemia with FLT3-ITD/D835 dual mutations2020
- Author(s)
  Kotoko Yamatani, Tomohiko Ai, Kaori Saitoh, Haeun Yang, Sonoko Kinjo, Kazuho Ikeo, Vivian Ruvolo, Po Yee Mak, Hironori Harada, Kazuhiro Katayama, Yoshikazu Sugimoto, Takashi Miida, Marina Konopleva, Weiguo Zhang, Bing Z. Carter, Yoshihide Hayashizaki, Michael Andreeff, Yoko Tabe.
- Organizer
  American Society of Hematology Annual Meeting
- Data Source
  KAKENHI-PROJECT-19KK0221
[Presentation] 器質的脳疾患を有する患者と有さない患者間でのけいれん発作後の心電図の比較2020
- Author(s)
  森　周介, 藍　智彦, 大友康裕
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08900

1. 森周介 (20362072)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. 田部陽子 (70306968)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. 岡崎康司 (80280733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 赤松和土 (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 三井田孝 (80260545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 鈴木浩也 (40788551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 早津徳人 (80543058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 牧山武 (30528302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大野聖子 (20610025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 山崎大樹 (40467428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 稲次基希 (00422486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 木村晋也 (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 里史明 (10468580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 渡邉達郎 (20595714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 堀敦詞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ai Tomohiko 藍 智彦

Research Projects

Research Products

Co-Researchers

心電図解析によるてんかん患者の発作予後予測に関する検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性白血病の内在性レトロウイルス活性化機序に基づく新規バイオマーカー開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Leukemic stem cell signatures to identify therapeutic targets of elderly acute myeloid leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

てんかん原因遺伝子の網羅的解析および心電図の診断有用性の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 不整脈2019 遺伝子病としての不整脈：遺伝子診断の光と影2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pandora will never regret having opened her box: reappraisal of genes associated with CPVT and SQTS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evidence-Based Assessment of Genes in Dilated Cardiomyopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of Lamin A/C at serine 22 modulates Nav 1.5 function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Nav 1.5 currents in HEK-293 cells2020

Ai Tomohiko 藍智彦

[Book] 不整脈2019　遺伝子病としての不整脈：遺伝子診断の光と影2019

[Presentation] 認知症患者で新たに発見されたCLCN1, RYR2及びDCTN1遺伝子変異：認知症患者における遺伝子検査から得た教訓2020