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iwahara naotoshi  岩原 直敏

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Iwahara Naotoshi  岩原 直敏

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Researcher Number 00613085
Other IDs
Affiliation (Current) 2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2017 – 2023: 札幌医科大学, 医学部, 助教
2016: 札幌医科大学, 医学部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Psychiatric science
Except Principal Investigator
Basic Section 47040:Pharmacology-related
Keywords
Principal Investigator
ミクログリア / 多発性硬化症 / エクソソーム / 細胞膜 / Actin / オートファジー / 膜修復 / 筋ジストロフィー / 骨格筋 / CTTN … More / SIRT1 / 細胞膜修復 / 痴呆 / 脳神経疾患 / アルツハイマー病 / 炎症 / SOCS3 / アミロイドβ / アルツハイマー 病 / 認知症 / アルツハイマー 廟 … More
Except Principal Investigator
SIRT1 / オートファジー / 骨格筋 / 老化 / サルコペニア / ミトコンドリア / マイトファジー / 筋ジストロフィー Less
  • Research Projects

    (5 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (13 People)
  •  Role of microglia-derived exosomes in the neurodegeneration of multiple sclerosis.Principal Investigator

    • Principal Investigator
      岩原 直敏
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Sapporo Medical University
  •  蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発

    • Principal Investigator
      細田 隆介
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  Activation of SIRT1 promotes membrane resealingPrincipal Investigator

    • Principal Investigator
      Naotoshi Iwahara
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Sapporo Medical University
  •  Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.

    • Principal Investigator
      Hosoda Ryusuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  Drug development for Alzheimer's disease targeting microglial dysfunctionPrincipal Investigator

    • Principal Investigator
      Iwahara Naotoshi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Sapporo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024

    • Author(s)
      Nakashima Ryuta、Hosoda Ryusuke、Tatekoshi Yuki、Iwahara Naotoshi、Saga Yukika、Kuno Atsushi
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 1365-1365

    • DOI

      10.1038/s41598-024-51746-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K19373, KAKENHI-PROJECT-22K06632
  • [Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023

    • Author(s)
      Hosoda Ryusuke, Nakashima Ryuta, Yano Masaki, Iwahara Naotoshi, Asakura Seidai, Nojima Iyori, Saga Yukika, Kunimoto Risa, Horio Yoshiyuki, Kuno Atsushi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 152 Issue: 2 Pages: 112-122

    • DOI

      10.1016/j.jphs.2023.04.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06632, KAKENHI-PROJECT-20K07068
  • [Journal Article] Activation of SIRT1 promotes membrane resealing via cortactin2022

    • Author(s)
      Iwahara Naotoshi、Azekami Kuya、Hosoda Ryusuke、Nojima Iyori、Hisahara Shin、Kuno Atsushi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 15328-15328

    • DOI

      10.1038/s41598-022-19136-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07541, KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
  • [Journal Article] SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX2022

    • Author(s)
      Kuno Atsushi、Hosoda Ryusuke、Tsukamoto Miki、Sato Tatsuya、Sakuragi Hiromi、Ajima Nami、Saga Yukika、Tada Kouhei、Taniguchi Yoshiki、Iwahara Naotoshi、Horio Yoshiyuki
    • Journal Title

      Cardiovascular Research

      Volume: 118 Issue: 17 Pages: 3360-3373

    • DOI

      10.1093/cvr/cvac026

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
  • [Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020

    • Author(s)
      Hosoda Ryusuke、Hamada Hiroki、Uesugi Daisuke、Iwahara Naotoshi、Nojima Iyori、Horio Yoshiyuki、Kuno Atsushi
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 376 Issue: 3 Pages: 385-396

    • DOI

      10.1124/jpet.120.000096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019

    • Author(s)
      Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
    • Journal Title

      J Alzheimers Dis.

      Volume: 68 Issue: 1 Pages: 323-337

    • DOI

      10.3233/jad-180904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
  • [Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019

    • Author(s)
      Yokokawa Kazuki、Iwahara Naotoshi、Hisahara Shin、Emoto Miho C.、Saito Taro、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Matsushita Takashi、Suzuki Syuuichirou、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 72 Issue: 3 Pages: 867-884

    • DOI

      10.3233/jad-190817

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
  • [Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019

    • Author(s)
      Saito Taro、Hisahara Shin、Iwahara Naotoshi、Emoto Miho C.、Yokokawa Kazuki、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Suzuki Syuuichirou、Matsushita Takashi、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 145 Pages: 20-32

    • DOI

      10.1016/j.freeradbiomed.2019.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
  • [Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019

    • Author(s)
      Fujiwara Daisuke、Iwahara Naotoshi、Sebori Rio、Hosoda Ryusuke、Shimohama Shun、Kuno Atsushi、Horio Yoshiyuki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 6 Pages: e0218329-e0218329

    • DOI

      10.1371/journal.pone.0218329

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
  • [Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019

    • Author(s)
      Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
    • Journal Title

      Journal of Alzheimer's disease

      Volume: 67 Issue: 3 Pages: 1079-1087

    • DOI

      10.3233/jad-180985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-16K10291, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-17K16388
  • [Journal Article] Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice.2017

    • Author(s)
      Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Fujikura M, Manabe T, Suzuki H, Matsushita T, Suzuki S, Shimohama S.
    • Journal Title

      J Alzheimers Dis.

      Volume: 55 Pages: 1235-1247

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K19776
  • [Presentation] 多発性硬化症を対象とした脳脊髄液由来細胞外小胞のプロテオーム解析2023

    • Author(s)
      岩原直敏
    • Organizer
      日本神経学会総会
    • Data Source
      KAKENHI-PROJECT-23K06967
  • [Presentation] 細胞外小胞からみた多発性硬化症2023

    • Author(s)
      岩原直敏
    • Organizer
      日本神経免疫学会 日本多発性硬化症協会研究助成金受賞者公演
    • Data Source
      KAKENHI-PROJECT-23K06967
  • [Presentation] レスベラトロールはオートTreatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.ファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2022

    • Author(s)
      Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] レスベラトロールは加齢による筋委縮を抑制し運動機能を維持する2021

    • Author(s)
      Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
    • Organizer
      第43回分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Treatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.2021

    • Author(s)
      Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] レスベラトロールはオートファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2021

    • Author(s)
      細田 隆介、久野 篤史、中島 龍汰、朝倉 聖大、岩原 直敏、野島 伊世里、國本 梨沙、堀尾 嘉幸
    • Organizer
      第72回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] ミクログリアによるAβクリアランスを標的とした治療戦略2018

    • Author(s)
      岩原直敏,下濱俊
    • Organizer
      第37回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K19776
  • [Presentation] Mesenchymal stem cell-conditioned medium promotes amyloid beta phagocytosis by MG6 cells (Mouse microglial cell line).2017

    • Author(s)
      Naotoshi Iwahara
    • Organizer
      World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19776
  • [Presentation] Mesenchymal stem cell-conditioned medium induces microglia into M2 phenotype and promotes amyloid β-phagocytosis2017

    • Author(s)
      Naotoshi Iwahara
    • Organizer
      Society for Neuroscience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19776
  • [Presentation] Microglial SOCS3 prevents IL6 production in Alzheimer's disease model mice2016

    • Author(s)
      Iwahara, Naotoshi
    • Organizer
      Society for Neuroscience Neuroscience 2016
    • Place of Presentation
      Sandiego
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19776
  • 1.  Hosoda Ryusuke (20749428)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 2.  久野 篤史 (30468079)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  堀尾 嘉幸 (30181530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  藤谷 直樹 (10374191)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  野島 伊世里 (10827398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  山田 崇史 (50583176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  村岡 賢 (50582681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  齋藤 太郎 (60718063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  久原 真 (80336403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  下濱 俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  藤井 博匡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  江本 美穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  嵯峨 幸夏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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