iwahara naotoshi 岩原直敏

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Iwahara Naotoshi 岩原直敏

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Researcher Number	00613085
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 札幌医科大学, 医学部, 助教 2016: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Psychiatric science Except Principal Investigator Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator ミクログリア / 多発性硬化症 / エクソソーム / 細胞膜 / Actin / オートファジー / 膜修復 / 筋ジストロフィー / 骨格筋 / CTTN … More / SIRT1 / 細胞膜修復 / 痴呆 / 脳神経疾患 / アルツハイマー病 / 炎症 / SOCS3 / アミロイドβ / アルツハイマー病 / 認知症 / アルツハイマー廟 … More Except Principal Investigator SIRT1 / オートファジー / 骨格筋 / 老化 / サルコペニア / ミトコンドリア / マイトファジー / 筋ジストロフィー Less

Role of microglia-derived exosomes in the neurodegeneration of multiple sclerosis.Principal Investigator
- Principal Investigator
  
  岩原直敏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Sapporo Medical University
蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発
- Principal Investigator
  
  細田隆介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Activation of SIRT1 promotes membrane resealingPrincipal Investigator
- Principal Investigator
  
  Naotoshi Iwahara
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Sapporo Medical University
Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.
- Principal Investigator
  
  Hosoda Ryusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Drug development for Alzheimer's disease targeting microglial dysfunctionPrincipal Investigator
- Principal Investigator
  
  Iwahara Naotoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024
- Author(s)
  Nakashima Ryuta、Hosoda Ryusuke、Tatekoshi Yuki、Iwahara Naotoshi、Saga Yukika、Kuno Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1365-1365
- DOI
  10.1038/s41598-024-51746-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19373, KAKENHI-PROJECT-22K06632
[Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023
- Author(s)
  Hosoda Ryusuke, Nakashima Ryuta, Yano Masaki, Iwahara Naotoshi, Asakura Seidai, Nojima Iyori, Saga Yukika, Kunimoto Risa, Horio Yoshiyuki, Kuno Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 2 Pages: 112-122
- DOI
  10.1016/j.jphs.2023.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06632, KAKENHI-PROJECT-20K07068
[Journal Article] Activation of SIRT1 promotes membrane resealing via cortactin2022
- Author(s)
  Iwahara Naotoshi、Azekami Kuya、Hosoda Ryusuke、Nojima Iyori、Hisahara Shin、Kuno Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15328-15328
- DOI
  10.1038/s41598-022-19136-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07541, KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
[Journal Article] SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX2022
- Author(s)
  Kuno Atsushi、Hosoda Ryusuke、Tsukamoto Miki、Sato Tatsuya、Sakuragi Hiromi、Ajima Nami、Saga Yukika、Tada Kouhei、Taniguchi Yoshiki、Iwahara Naotoshi、Horio Yoshiyuki
- Journal Title
  
  Cardiovascular Research
  
  Volume: 118 Issue: 17 Pages: 3360-3373
- DOI
  10.1093/cvr/cvac026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
[Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020
- Author(s)
  Hosoda Ryusuke、Hamada Hiroki、Uesugi Daisuke、Iwahara Naotoshi、Nojima Iyori、Horio Yoshiyuki、Kuno Atsushi
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 376 Issue: 3 Pages: 385-396
- DOI
  10.1124/jpet.120.000096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07102
[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019
- Author(s)
  Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 68 Issue: 1 Pages: 323-337
- DOI
  10.3233/jad-180904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019
- Author(s)
  Yokokawa Kazuki、Iwahara Naotoshi、Hisahara Shin、Emoto Miho C.、Saito Taro、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Matsushita Takashi、Suzuki Syuuichirou、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Issue: 3 Pages: 867-884
- DOI
  10.3233/jad-190817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019
- Author(s)
  Saito Taro、Hisahara Shin、Iwahara Naotoshi、Emoto Miho C.、Yokokawa Kazuki、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Suzuki Syuuichirou、Matsushita Takashi、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 145 Pages: 20-32
- DOI
  10.1016/j.freeradbiomed.2019.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019
- Author(s)
  Fujiwara Daisuke、Iwahara Naotoshi、Sebori Rio、Hosoda Ryusuke、Shimohama Shun、Kuno Atsushi、Horio Yoshiyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 6 Pages: e0218329-e0218329
- DOI
  10.1371/journal.pone.0218329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019
- Author(s)
  Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
- Journal Title
  
  Journal of Alzheimer's disease
  
  Volume: 67 Issue: 3 Pages: 1079-1087
- DOI
  10.3233/jad-180985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-16K10291, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-17K16388
[Journal Article] Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice.2017
- Author(s)
  Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Fujikura M, Manabe T, Suzuki H, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 55 Pages: 1235-1247
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19776
[Presentation] 多発性硬化症を対象とした脳脊髄液由来細胞外小胞のプロテオーム解析2023
- Author(s)
  岩原直敏
- Organizer
  日本神経学会総会
- Data Source
  KAKENHI-PROJECT-23K06967
[Presentation] 細胞外小胞からみた多発性硬化症2023
- Author(s)
  岩原直敏
- Organizer
  日本神経免疫学会　日本多発性硬化症協会研究助成金受賞者公演
- Data Source
  KAKENHI-PROJECT-23K06967
[Presentation] レスベラトロールはオートTreatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.ファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2022
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールは加齢による筋委縮を抑制し運動機能を維持する2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第43回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] Treatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールはオートファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2021
- Author(s)
  細田隆介、久野篤史、中島龍汰、朝倉聖大、岩原直敏、野島伊世里、國本梨沙、堀尾嘉幸
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] ミクログリアによるAβクリアランスを標的とした治療戦略2018
- Author(s)
  岩原直敏,下濱俊
- Organizer
  第３７回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19776
[Presentation] Mesenchymal stem cell-conditioned medium promotes amyloid beta phagocytosis by MG6 cells (Mouse microglial cell line).2017
- Author(s)
  Naotoshi Iwahara
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19776
[Presentation] Mesenchymal stem cell-conditioned medium induces microglia into M2 phenotype and promotes amyloid β-phagocytosis2017
- Author(s)
  Naotoshi Iwahara
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19776
[Presentation] Microglial SOCS3 prevents IL6 production in Alzheimer's disease model mice2016
- Author(s)
  Iwahara, Naotoshi
- Organizer
  Society for Neuroscience Neuroscience 2016
- Place of Presentation
  Sandiego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19776

1. Hosoda Ryusuke (20749428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 久野篤史 (30468079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 堀尾嘉幸 (30181530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 藤谷直樹 (10374191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野島伊世里 (10827398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 山田崇史 (50583176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 村岡賢 (50582681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 齋藤太郎 (60718063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 久原真 (80336403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 下濱俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤井博匡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 江本美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 嵯峨幸夏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

iwahara naotoshi 岩原 直敏

Iwahara Naotoshi 岩原 直敏

Research Projects

Research Products

Co-Researchers

Role of microglia-derived exosomes in the neurodegeneration of multiple sclerosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of SIRT1 promotes membrane resealingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug development for Alzheimer's disease targeting microglial dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of SIRT1 promotes membrane resealing via cortactin2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019

Author(s)

Journal Title

DOI

Data Source

iwahara naotoshi 岩原直敏

Iwahara Naotoshi 岩原直敏