Yamaguchi Hiroo 山口浩雄

… Alternative Names

YAMAGUCHI Hiroo 山口浩雄

Less

Researcher Number	00701830
Other IDs
Affiliation (Current)	2025: 令和健康科学大学, リハビリテーション学部, 教授 2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 九州大学, 医学研究院, 共同研究員 2023: 令和健康科学大学, リハビリテーション学部, 特任教授 2017 – 2023: 九州大学, 大学病院, 特任講師 2021: 九州大学, 医学研究院, 学術研究員 2015 – 2016: 九州大学, 大学病院, 講師 2013 – 2014: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Neurology / Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator αシヌクレイン / マウスモデル / 多系統萎縮症 / モデルマウス / α-シヌクレイン / 一次性進行型多発性硬化症 / α-synuclein / α- シヌクレイン / 一次進行型多発性硬化症 / 多発性硬化症 / DJ-1 / 酸化ストレス / パーキンソン病 … More Except Principal Investigator … More ミクログリア / コネキシン / 多系統萎縮症 / オリゴデンドログリア / 多発性硬化症 / シヌクレイン / 脱髄 / モデルマウス / アストログリア / オリゴデンドロサイト / αシヌクレイン / グリア炎症 / バイオマーカー / 視神経脊髄炎 / ギャップ結合 / アストロサイト / 脱髄疾患 / 神経変性疾患 / オリゴマー / アルツハイマー病 / グリアシンシチウム / 海馬 / 動物モデル / 皮質異形成 / てんかん / 伝搬 / 多系統萎縮 / α-Synuclein / グリア細胞 / 進行型多発性硬化症 / 小脳型多系統萎縮症 / グリア標的治療 / グリオパチー / α-シヌクレイン / 神経内科疾患 / α―シヌクレイン / 神経炎症 / 小脳失調 / αーシヌクレイン / 末梢神経障害 / SOD1 / ケモカイン / 変異SOD1トランスジェニックマウス / ミスフォールド蛋白 / 筋萎縮性側索効果症 / CCR2 / 変異SOD1 / 異常蛋白 / 末梢神経 / マクロファージ / 筋萎縮性側索硬化症 / トランスジェニックマウス / CSF1R阻害薬 / intermediate monocytes / 神経科学 / タウ蛋白 / 病的タウ / 毒性アミロイドベータ / CD33 / リン酸化タウタンパク / マイクロRNA / エキソソーム / アミロイドβタンパク / 老化 / 薬理学 / 痴呆 / 脳神経疾患 / インスリンシグナリング / 培養細胞 / 毒性ターン / リン酸化タウ蛋白 / 毒性ターン構造 / アミロイドβ蛋白 / アポモルフィン / 糖尿病 / マウスモデル / 実験的自己免疫性脳脊髄炎 / T細胞 / 免疫グリア細胞間相互作用 / GWAS / ネットワーク解析 / 脳磁図 / グリア / モデル動物 / 神経免疫学 / 臨床神経生理学 / 脳波 / ネットワーク / エネルギー供給障害 / グリアアセンブリ / 栄養トランスポーター / 栄養供給障害 / てんかん動物モデル / コネキシン蛋白群 Less

Investigation of early biomarkers and new treatments for multiple system atrophy focusing on alpha-synuclein transmission
- Principal Investigator
  
  松瀬大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
ヘミチャネル阻害薬を用いたαシヌクレイン伝播阻止による多系統萎縮症の治療法開発
- Principal Investigator
  
  真崎勝久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
単一細胞RNA解析による多系統萎縮症増悪性ミクログリア亜群の同定と同細胞標的療法Principal Investigator
- Principal Investigator
  
  山口浩雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Development of innovative microglia-targeted therapy using multiple system atrophy model mice
- Principal Investigator
  
  Matsuse Dai
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Novel therapy for progressive multiple sclerosis and multiple system atrophy by glial regulation
- Principal Investigator
  
  Katsuhisa Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Misfold protein removal therapy with CCR2-positive cells from peripheral nerves in motor neuron disease
- Principal Investigator
  
  Yamasaki Ryo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Establishment of primary-progressive multiple sclerosis (PPMS)/multiple system atrophy (MSA) mice modelPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hiroo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
A novel mice model of MSA by overexpression of mutant alpha-synuclein in oligodendroglia in a temporarily restrictive manner using Tet-off system
- Principal Investigator
  
  Matsuse Dai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Impairment of insulin signaling in Alzheimer's disease and combined therapy with apomorphine and insulin
- Principal Investigator
  
  Ohyagi Yasumasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Ehime University
Elucidation of the role of glial cell in tau transmission and axonal degeneration in Alzheimer's disease and targeted therapy with glial cell
- Principal Investigator
  
  Asai Hirohide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Development of new therapeutic options for multiple sclerosis by suppression of CNS immune system augmentation due to the malfunction of astroglia connexin
- Principal Investigator
  
  Yamasaki Ryo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
New therapeutic investigation targetting to cell membrane protein induced by epileptic brain network
- Principal Investigator
  
  Shigeto Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Analysis for mechanism of spontaneous seizures in a rat model of multiple prenatal freeze lesioning and development of novel treatment for epilepsy focusing on connexin
- Principal Investigator
  
  Kamada Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kurume University
  Kyushu University
Extensive disruption of energy transports via glial syncytium in demyelinating diseases
- Principal Investigator
  
  Masaki Katsuhisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
To generate and analyze new Parkinson's disease mice model with increased oxidative stressPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Hiroo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation2023
- Author(s)
  Nagata Satoshi、Yamasaki Ryo、Takase Ezgi Ozdemir、Iida Kotaro、Watanabe Mitsuru、Masaki Katsuhisa、Wijering Marion Heleen Cath?rine、Yamaguchi Hiroo、Kira Jun-ichi、Isobe Noriko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 9 Pages: 1217-1217
- DOI
  10.3390/biology12091217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-22K07540, KAKENHI-PROJECT-23K06965
[Journal Article] Shadowboxing-induced reflex seizures in a patient with focal epilepsy.2022
- Author(s)
  Okadome T, Takeuchi H, Yamaguchi T, Mukaino T, Ogata H, Masaki K, Shigeto H, Isobe N.
- Journal Title
  
  Epilepsy Behav Rep.
  
  Volume: 19 Pages: 100543-100543
- DOI
  10.1016/j.ebr.2022.100543
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07889
[Journal Article] Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy2022
- Author(s)
  Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka1, Eriko Matsuo, Shotaro Hayashida, Mitsuru Watanabe, Takuya Matsushita, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
- Journal Title
  
  Brain Pathology
  
  Volume: - Issue: 3 Pages: 1-16
- DOI
  10.1111/bpa.13131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07438, KAKENHI-PROJECT-22K07540, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-21K20873, KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-23K19567, KAKENHI-PROJECT-23K06965
[Journal Article] Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination.2021
- Author(s)
  Une H, Yamasaki R, Nagata S, Yamaguchi H, Nakamuta Y, Indiasari UC, Cui YW, Shinoda K, Masaki K, Gotz M, Kira J:
- Journal Title
  
  J Neuroinflammation
  
  Volume: 18 Issue: 1 Pages: 126-126
- DOI
  10.1186/s12974-021-02176-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-20K20470
[Journal Article] Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type2020
- Author(s)
  Dai Matsuse, Ryo Yamasaki, Guzailiayi Maimaitijiang, Hiroo Yamaguchi, Katsuhisa Masaki, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 349 Pages: 577395-577395
- DOI
  10.1016/j.jneuroim.2020.577395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07501, KAKENHI-PROJECT-20K07889
[Journal Article] Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis2020
- Author(s)
  Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira J.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 4 Pages: 2160-2169
- DOI
  10.1073/pnas.1901294117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.2018
- Author(s)
  Fujita A, Yamaguchi H, Yamasaki R, Cui Y, Matsuoka Y, Yamada KI, Kira JI.
- Journal Title
  
  J Neuroinflammation.
  
  Volume: 15 Issue: 1 Pages: 227-227
- DOI
  10.1186/s12974-018-1251-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14884, KAKENHI-PROJECT-16H02657, KAKENHI-PROJECT-16K09694, KAKENHI-PROJECT-17K19663
[Journal Article] Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia2018
- Author(s)
  Fang Mei、Yamasaki Ryo、Li Guangrui、Masaki Katsuhisa、Yamaguchi Hiroo、Fujita Atsushi、Isobe Noriko、Kira Jun-ichi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 2588-2588
- DOI
  10.3389/fimmu.2018.02588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02657, KAKENHI-PROJECT-16K09694, KAKENHI-PROJECT-17K19663
[Journal Article] Dermatomyositis complicated with asymmetric peripheral neuritis on exacerbation: a case report and literature review2016
- Author(s)
  Takashi Irie, Hiroshi Shigeto, Junpei Koge, Hiroo Yamaguchi, Hiroyuki Murai, Jun-ichi Kira
- Journal Title
  
  Clinical & Experimental Neuroimmunology
  
  Volume: 7 Issue: 4 Pages: 373-380
- DOI
  10.1111/cen3.12332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09340
[Journal Article] Stroke-like episodesを呈さずに痙攣重積と横紋筋融解症で発症したmitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes（MELAS）の1例2016
- Author(s)
  横山　淳, 山口　浩雄, 重藤　寛史, 内海　健, 村井　弘之, 吉良　潤一
- Journal Title
  
  臨床神経学
  
  Volume: 56 Pages: 204-207
- NAID
  130005142028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09340
[Journal Article] Multimodal diagnostic approach for limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies2015
- Author(s)
  Takahiko Mukaino, Wataru Shiraishi, Toshitsugu Kamada, Taira Uehara, Hiroo Yamaguchi, Hiroshi Shigeto, Noriko Akutagawa, Takeo Yoshimura, Hiroyuki Murai and Jun-ichi Kira
- Journal Title
  
  CLINICAL AND EXPERIMENTAL NEUROIMMUNOLOGY
  
  Volume: 6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09340
[Presentation] Early and extensive alterations of glial connexins in multiple system atrophy2023
- Author(s)
  Masaki Katsuhisa, Nishimura Yuji, Matsuse Dai, Yamaguchi Hiroo, Tanaka Tatsunori, Sadashima Shoko, Sasagasako Naokazu, Yamasaki Ryo, Iwaki Toru, Isobe Noriko, Kira Junichi
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Marked upregulation of GPR17-positive premyelinating oligodendrocytes in multiple system atrophy2023
- Author(s)
  Nishimura Yuji, Masaki Katsuhisa, Matsuse Dai, Yamaguchi Hiroo, Tanaka Tatsunori, Sadashima Shoko, Sasagasako Naokazu, Yamasaki Ryo, Honda Hiroyuki, Isobe Noriko, Iwaki Toru, Kira Jun-ichi
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Identification of a unique microglia population exacerbating multiple system atrophy2023
- Author(s)
  松瀬大, 山口浩雄, 西村由宇慈, 眞﨑勝久, 田中辰典, 雑賀徹, 原田雅也, 田中謙二, 山﨑亮, 磯部紀子, 吉良潤一
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] 中枢神経作用コネキシン阻害薬による多系統萎縮症小脳型モデルマウスの治療2023
- Author(s)
  原田雅也, 眞崎勝久, 松瀬大, 山口浩雄, 西村由宇慈, 高瀬オズデミールエズギ, 田中栄蔵, 田中辰典, 山崎亮, 竹内英之, 谷脇考恭, 磯部紀子, 吉良潤一
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Identification of a unique microglia population exacerbating multiple system atrophy2023
- Author(s)
  Matsuse Dai, Yamaguchi Hiroo, Nishimura Yuji, Masaki Katsuhisa, Tanaka Tatsunori, Saiga Toru, Harada Masaya, Tanaka Kenji, Yamasaki Ryo, Isobe Noriko, Kira Jun-ichi
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] A centrally acting connexin hemichannel blocker attenuates multiple system atrophy-cerebellar type2023
- Author(s)
  原田雅也, 眞﨑勝久, 松瀨大, 山口浩雄, 西村由宇慈, オズデミールエズギ, 田中栄蔵, 田中辰典, 山﨑亮, 竹内英之, 谷脇考恭, 磯部紀子, 吉良潤一
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Early and extensive alterations of glial connexins in multiple system atrophy2023
- Author(s)
  眞崎勝久, 西村由宇慈, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ケ迫直一, 山﨑亮, 岩城徹, 磯部紀子, 吉良潤一
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Marked upregulation of GPR17-positive premyelinating oligodendrocytes in multiple system atrophy2023
- Author(s)
  西村由宇慈, 眞﨑勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ケ迫直一, 山﨑亮, 本田裕之, 磯部紀子, 岩城徹, 吉良潤一
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] 中枢作用コネキシン阻害薬を用いた多系統萎縮症モデルマウスに対する治療効果の検討2023
- Author(s)
  原田雅也，眞﨑勝久，松瀨大，山口浩雄，西村由宇慈，高瀬オズデミールエズギ，田中栄蔵，田中辰典，山﨑亮，竹内英之，谷脇考恭，磯部紀子，吉良潤一
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Marked upregulation of GPR17-positive premyelinating oligodendrocytes in multiple system atrophy2023
- Author(s)
  Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Hiroyuki Honda, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18266
[Presentation] Early and extensive alterations of glial connexins in multiple system atrophy2023
- Author(s)
  Katsuhisa Masaki, Yuji Nishimura, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06965
[Presentation] Early and extensive alterations of glial connexins in multiple system atrophy2023
- Author(s)
  Katsuhisa Masaki, Yuji Nishimura, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K18266
[Presentation] Connexin hemichannel blockade ameliorates EAE by suppressing glial inflammation2023
- Author(s)
  Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-ichi Kira, Hideyuki Takeuchi, Noriko Isobe
- Organizer
  European Charcot Foundation Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18266
[Presentation] Early loss of connexin 32 in multiple system atrophy; implication for pathogenesis of demyelination2022
- Author(s)
  Yuji NIshimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Shoko Sadashima, Ryo Yamasaki, Toru Iwaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Synucleionopathy-Associated Microglia Uncovered by a Novel Multiple System Atrophy-Cerebellar Type (MSA-c) Mouse Model2022
- Author(s)
  Jun-ichi Kira, Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Ryo Yamasaki, Noriko Isobe
- Organizer
  147th Annual Meeting American Neurological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] .Identification of synucleinopathy associated microglia in a novel mouse model of multiple system atrophy (MSA)-cerebellar type2022
- Author(s)
  Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Kenji Tanaka, Ryo Yamasaki, Noriko lsobe, Jun-ichi Kira.
- Organizer
  Neuroscience 2022 (San Diego, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] A population of inflammatory microglia exacerbates a novel mouse model of multiple system atrophy.2022
- Author(s)
  Dai Matsuse, Hiroo Yamaguchi, Katsuhisa Masaki, Yuji Nishimura, Tatsunori Tanaka, Toru Saiga, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Synucleinopathy-associated microglia uncovered by a novel multiple system atrophy-cerebellar type (MSA-C) mouse model.2022
- Author(s)
  Jun-ichi Kira, Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Ryo Yamasaki, Noriko Isobe.
- Organizer
  The 147th Annual Meeting of the American Neurological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] A population of inflammatory microglia exacerbates a novel mouse model of multiple system atrophy2022
- Author(s)
  Dai Matsuse, Hiroo Yamaguchi, Katsuhisa Masaki, Yuji Nishimura, Tatsunori Tanaka, Toru Saiga, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Identification of synucleinopathy associated microglia in a novel mouse model of multiple system atrophy (MSA)-cerebellar type2022
- Author(s)
  Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  Neuroscience 2022
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] 中枢神経脱髄におけるオリゴデンドログリア変性によるミクログリア活性化メカニズムの解明2022
- Author(s)
  松下拓也, 西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 吉良潤一, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07889
[Presentation] 多系統萎縮症におけるconnexin蛋白群の早期かつ広範な変化と脱髄病態との関連2022
- Author(s)
  西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ヶ迫直一, 山崎亮, 磯部紀子, 岩城徹, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07889
[Presentation] Early loss of connexin 32 in multiple system atrophy; implication for pathogenesis of demyelination2022
- Author(s)
  Yuji NIshimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Shoko Sadashima, Ryo Yamasaki, Toru Iwaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 小脳型多系統萎縮症モデルマウスを用いた新規創薬ターゲットの探索2022
- Author(s)
  山口浩雄, 西村由宇慈, 松瀬大, 眞崎勝久, 田中辰典, 雑賀徹, 原田雅也, 田中謙二, 山埼亮, 磯部紀子, 吉良潤一
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 小脳型多系統萎縮症モデルマウスを用いた新規創薬ターゲットの探索2022
- Author(s)
  山口浩雄, 西村由宇慈, 松瀬大, 眞崎勝久, 田中辰典, 雑賀徹, 原田雅也, 田中謙二, 山埼亮, 磯部紀子, 吉良潤一
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07889
[Presentation] 多系統萎縮症におけるconnexin蛋白群の早期かつ広範な変化と脱髄病態との関連2022
- Author(s)
  西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ヶ迫直一, 山崎亮, 磯部紀子, 岩城徹, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 小脳型多系統萎縮症モデルマウスを用いた新規創薬ターゲットの探索2022
- Author(s)
  山口浩雄, 西村由宇慈, 松瀬大, 眞崎勝久, 田中辰典, 雑賀徹, 原田雅也, 田中謙二, 山埼亮, 磯部紀子, 吉良潤一
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] A population of inflammatory microglia exacerbates a novel mouse model of multiple system atrophy2022
- Author(s)
  Dai Matsuse, Hiroo Yamaguchi, Katsuhisa Masaki, Yuji Nishimura, Tatsunori Tanaka, Toru Saiga, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  63rd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] 中枢神経脱髄におけるオリゴデンドログリア変性によるミクログリア活性化メカニズムの解明2022
- Author(s)
  松下拓也, 西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 吉良潤一, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 多系統萎縮症におけるconnexin蛋白群の早期かつ広範な変化と脱髄病態との関連2022
- Author(s)
  西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ヶ迫直一, 山崎亮, 磯部紀子, 岩城徹, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Synucleionopathy-Associated Microglia Uncovered by a Novel Multiple System Atrophy-Cerebellar Type (MSA-c) Mouse Model2022
- Author(s)
  Jun-ichi Kira, Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Ryo Yamasaki, Noriko Isobe
- Organizer
  147th American Neurological Association (ANA)
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] Identification of synucleinopathy associated microglia in a novel mouse model of multiple system atrophy (MSA)-cerebellar type2022
- Author(s)
  Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Kenji Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-ichi Kira
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 中枢神経脱髄におけるオリゴデンドログリア変性によるミクログリア活性化メカニズムの解明2022
- Author(s)
  松下拓也, 西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 吉良潤一, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07540
[Presentation] 新規小脳型多系統萎縮症モデルのCSF-1R阻害剤治療2021
- Author(s)
  松瀬大、山口浩雄、眞﨑勝久、西村由宇慈、田中辰典、雑賀徹、田中謙二、山﨑亮、吉良潤一、磯部紀子
- Organizer
  第15回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 小脳型多系統萎縮症/一次進行型多発性硬化症モデルマウスの樹立とこれら疾患の新規創薬ターゲットの探索2021
- Author(s)
  山口浩雄、松瀬大、眞﨑勝久、雑賀徹、西村由宇慈、田中辰典、田中謙二、山﨑亮、吉良潤一、磯部紀子
- Organizer
  第39回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] 新規小脳型多系統萎縮症モデルのCSF-1R阻害剤治療.2021
- Author(s)
  松瀬大, 山口浩雄, 眞﨑勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山﨑亮, 吉良潤一, 磯部紀子
- Organizer
  第15回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] 小脳型多系統萎縮症/一次進行型多発性硬化症モデルマウスの樹立とこれら疾患の新規創薬ターゲットの探索2021
- Author(s)
  山口浩雄、松瀬大、眞崎勝久、雑賀徹、西村由宇慈、田中辰典、田中謙二、山崎亮、吉良潤一、磯部紀子
- Organizer
  第39回日本神経治療学会
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Elimination of CSF1R-positive microglia exacerbates a novel mouse model of multiple system atroph2021
- Author(s)
  Nishimura Yuji, Masaki Katsuhisa, Matsuse Dai, Yamaguchi Hiroo, Saiga Toru, Tanaka Tatsunori, Sadashima Shoko, Yamasaki Ryo, Tanaka Kenji, Iwaki Toru, Kira Jun-ichi
- Organizer
  62nd Annual Meeting of the Japanese Society of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Eliminaion of CSF1R-positive microglia exacerbates a novel mouse model of multiple system atrophy2021
- Author(s)
  西村由宇慈, 真崎勝久, 松瀬大, 山口浩雄, 雑賀徹, 田中辰典, 貞島祥子, 山崎亮, 田中謙二, 岩城徹, 吉良潤一
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] Early dysregulation of connexins in astroglia and oligodendroglia in multiple system atrophy2021
- Author(s)
  眞崎勝久, 西村由宇慈, 松瀬大, 山口浩雄, 雑賀徹, 田中辰典, 貞島祥子, 山崎亮, 田中謙二, 岩城徹, 吉良潤一
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症モデルの樹立2021
- Author(s)
  松瀬大, 山口浩雄, 眞﨑勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山﨑亮, 吉良潤一
- Organizer
  第14回日本パーキンソン病・運動障害疾患学会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] Early dysregulation of connexins in astroglia and oligodendroglia in multiple system atrophy2021
- Author(s)
  Masaki Katsuhisa, Nishimura Yuji, Matsuse Dai, Yamaguchi Hiroo, Saiga Toru, Tanaka Tatsunori, Sadashima Shoko, Yamasaki Ryo, Tanaka Kenji, Iwaki Toru, Kira Jun-ichi
- Organizer
  62nd Annual Meeting of the Japanese Society of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] 新規小脳型多系統萎縮症モデルのCSF-1R阻害剤治療2021
- Author(s)
  松瀬大、山口浩雄、眞﨑勝久、西村由宇慈、田中辰典、雑賀徹、田中謙二、山﨑亮、吉良潤一、磯部紀子
- Organizer
  第15回パーキンソン病運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症モデルの樹立2021
- Author(s)
  松瀬大、山口浩雄、眞﨑勝久、西村由宇慈、田中辰典、雑賀徹、田中謙二、山﨑亮、吉良潤一
- Organizer
  第14回パーキンソン病運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] Early decrease of peripheral blood intermediate monocytes in multiple system atrophy cerebellar-type2021
- Author(s)
  Dai Matsuse, Ryo Yamasaki, Guzailiayi Maimaitijiang, Hiroo Yamaguchi, Jun-ichi Kira , Noriko Isobe
- Organizer
  62nd Annual Meeting of the Japanese Society of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07438
[Presentation] Drug targets for multiple system atrophy and primary progressive multiple sclerosis by a novel model2020
- Author(s)
  西村由宇慈, 真崎勝久, 松瀬大, 山口浩雄, 雜賀徹, 田中辰典, 渡邊充, 山﨑亮, 田中謙二, 吉良潤一
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] Drug targets for multiple system atrophy and primary progressive multiple sclerosis by a novel model2020
- Author(s)
  Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Tatsunori Tanaka, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  61ｓｔ Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Gene expression profile of multiple system atrophy/primary progressive multiple sclerosis mice model2020
- Author(s)
  Hiroo Yamaguchi, Tasunori Tanaka, Dai Mtasuse, Yuji Nishimura, Katsuhisa Masaki, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  61ｓｔ Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Gene expression profile of multiple system atrophy/primary progressive multiple sclerosis mice model.2020
- Author(s)
  Yamaguchi Hiroo, Tanaka Tatsunori, Matsuse Dai, Nishimura Yuji, Masaki Katsuhisa, Saiga Toru, Watanabe Mitsuru, Yamasaki Ryo, Tanaka Kenji, Kira Jun-ichi
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] 新規小脳型多系統萎縮症モデルによる脱髄・神経細胞障害機序とグリア制御による新規治療法開発の試み2020
- Author(s)
  西村由宇慈, 眞﨑勝久, 松瀬大, 山口浩雄, 雑賀徹, 田中辰典, 田中謙二, 山﨑亮, 岩城徹, 吉良潤一.
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] 多系統萎縮症および一次進行型多発性硬化症モデルマウスを用いた治療標的探索2020
- Author(s)
  田中辰典、西村由宇慈、真崎勝久、松瀬大、山口浩雄、雑賀徹、渡邊充、山崎亮、田中謙二、吉良潤一
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] Therapeutic drug search using model mice for multiple system atrophy and primary progressive multiple sclerosis.2020
- Author(s)
  Tanaka Tatsunori, Nishimura Yuji, Masaki Katsuhisa, Matsuse Dai, Yamaguchi Hiroo, Saiga Toru, Watanabe Mitsuru, Yamasaki Ryo, Tanaka Kenji, Kira Jun-ichi
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症モデルの樹立2020
- Author(s)
  松瀬大, 山口浩雄, 眞﨑勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山﨑亮, 吉良潤一
- Organizer
  第14回日本パーキンソン病・運動障害疾患学会（Movement Disorder Society-Japan）
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Gene expression profile of multiple system atrophy/primary progressive multiple sclerosis mice model2020
- Author(s)
  山口浩雄, 田中辰典, 松瀬大, 西村由宇慈, 真崎勝久, 雑賀徹, 渡邊充, 山﨑亮, 田中謙二, 吉良潤一
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] Early decrease of peripheral blood intermediate monocytes in multiple system atrophy cerebellar-type.2020
- Author(s)
  Matsuse Dai, Yamasaki Ryo, Maimaitijiang Guzailiayi, Yamaguchi Hiroo, Kira Jun-ichi
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] 新規小脳型多系統萎縮症モデルによる脱髄・神経細胞障害機序とグリア制御による新規治療法開発の試み2020
- Author(s)
  西村由宇慈, 眞﨑勝久, 松瀬大, 山口浩雄, 雑賀徹, 田中辰典, 田中謙二, 山﨑亮, 岩城徹, 吉良潤一
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] Therapeutic drug search using model mice for multiple system atrophy and primary progressive multiple sclerosis2020
- Author(s)
  Tatsunori Tanaka, Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka and Jun-ichi Kira
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Early decrease of peripheral blood intermediate monocytes in multiple system atrophy cerebellar-type2020
- Author(s)
  Dai Matsuse, Ryo Yamasaki, Maimaitjiang Guzailiayi, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  61ｓｔ Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Expression of mutant α-synuclein in oligodendrocytes induces remarkable glial inflammation and demyelination in the spinal cord and brainstem/cerebellar white matter: A novel model of multiple system atrophy-cerebellar type and primary progressive multiple sclerosis2019
- Author(s)
  Hiroo Yamaguchi, Dai Matsuse, Katsushisa Masaki, Toru Saiga, Yuji Nishimura, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] Expression of mutant α-synuclein in oligodendrocytes induces remarkable glial inflammation and demyelination in the spinal cord and brainstem/cerebellar white matter: A novel model of multiple system atrophy-cerebellar type and primary progressive multiple sclerosis2019
- Author(s)
  Hiroo Yamaguchi, Dai Matsuse, Katsushisa Masaki, Toru Saiga, Yuji Nishimura, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症・一次進行型多発性硬化症モデル2019
- Author(s)
  真崎勝久、松瀬大、山口浩雄、雑賀徹、西村由宇慈、田中辰典、渡邉充、田中謙二、山﨑亮、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] A novel model of multiple system atrophy-cerebellar type and primary progressive multiple sclerosis2019
- Author(s)
  Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Yuji Nishimura, Tatsunori Tanaka, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  The 24th Annual Meeting of the Japan Glia
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] A novel mice model of PPMS/MSA by oligodendroglial overexpression of mutant alpha-synuclein2019
- Author(s)
  Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Katsuhisa Masaki, Yiwen Cui, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  第42回日本神経科学大会／第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] A novel mice model of PPMS/MSA by oligodendroglial overexpression of mutant alpha-synuclein2019
- Author(s)
  Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Katsuhisa Masaki, Yiwen Cui, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  第42回日本神経科学大会／第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] A novel model of multiple system atrophy-cerebellar type and primary progressive multiple sclerosis2019
- Author(s)
  Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Yuji Nishimura, Tatsunori Tanaka, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  The 24th Annual Meeting of the Japan Glia
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] A novel model of primary progressive multiple sclerosis by oligodendroglial mutant alpha-synuclein2019
- Author(s)
  Toru Saiga, Hiroo Yamaguchi, Dai Matsuse, Katsuhisa Masaki, Yiwen Cui, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07976
[Presentation] オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症・一次進行型多発性硬化症モデル2019
- Author(s)
  真崎勝久、松瀬大、山口浩雄、雑賀徹、西村由宇慈、田中辰典、渡邉充、田中謙二、山﨑亮、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] A novel model of primary progressive multiple sclerosis by oligodendroglial mutant alpha-synuclein2019
- Author(s)
  Toru Saiga, Hiroo Yamaguchi, Dai Matsuse, Katsuhisa Masaki, Yiwen Cui, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07501
[Presentation] Expression of mutant α-synucelin in oligodendrocytes during myelination period induces remarkable glial inflammation and demyelination in the spinal cord and brainstem/cerebellar white matter: a novel model of multiple system atrophy-cerebellar type and primary progressive mutliple sclerosis2019
- Author(s)
  Yamaguchi H, et al.
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Astroglial connexin (Cx)30 and Cx43 and oligodendroglial Cx47 differentially modulate acute and chronic experimental autoimmune encephalomyelitis2018
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi
- Organizer
  International Society of Neuroimmunology Congress 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Oligodendroglia-specific conditional ablation of connexin 47 is sufficient to produce relapse and progression in demyelinating disease2018
- Author(s)
  Yinan Zhao, Ryo Yamasaki, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Oligodendroglia-specific conditional ablation of connexin 47 is sufficient to produce relapse and　progression in demyelinating disease2018
- Author(s)
  Yinan Zhao, Ryo Yamasaki, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Astroglial connexin (Cx)30 and Cx43 and oligodendroglial Cx47 differentially modulate acute and chronic experimental autoimmune encephalomyelitis2018
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi
- Organizer
  International Society of Neuroimmunology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Oligodendroglia-specific connexin47 deletion produces a relapse-remitting multiple sclerosis model2018
- Author(s)
  Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD.
- Organizer
  第59回日本神経学会学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Elucidation of the effects of gap junction protein connexin on the pathogenesis of multiple sclerosis model mice and development of new therapeutic options by functional modification ギャップ結合蛋白コネキシンが多発性硬化症モデルマウスの病態に及ぼす影響の解析2018
- Author(s)
  Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Mei Fang MD, Guangrui Li MD, PhD, Hayato Une MD, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD.
- Organizer
  第61回日本神経化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] A novel secondary progressive multiple sclerosis model by oligodendroglia-specific inducible conditional knockout of connexin 472018
- Author(s)
  Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD.
- Organizer
  International Society of Neuroimmunology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Oligodendroglia-specific connexin47 deletion produces a relapse-remitting multiple sclerosis model2018
- Author(s)
  Ryo Yamasaki, Yinan Zhao, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] A novel secondary progressive multiple sclerosis model by oligodendroglia-specific inducible conditional knockout of connexin 472018
- Author(s)
  Ryo Yamasaki, Yinan Zhao, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  International Society of Neuroimmunology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis2017
- Author(s)
  Ryo Yamasaki, Mei Fang, Yinan Zhao, Hayato Une, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  The 22nd Annual Meeting of the Japan Glia
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Oligodendroglia-specific Connexin 47 deletion induced relapse-remitting EAE model mice.2017
- Author(s)
  Ryo Yamasaki, Yinan Zhao, Hiroo Yamaguchi, Jun-ichi Kira
- Organizer
  the 10th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] T-05-040C Astrocytic connexin 30 deletion leads to hypersensitivity in a MPTP mouse model of Parkinson’s disease2017
- Author(s)
  Atsushi Fujita, MD,1 Hiroo Yamaguchi, MD, PhD,1 Ryo Yamasaki, MD, PhD,1 Yuta Matsuoka, PhD,2 Ken-ichi Yamada, PhD,2 Jun-ichi Kira, MD, PhD
- Organizer
  Euroglia2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Astroglial and Oligodendroglial Connexins Differentially Influence Both Acute and Chronic Progressive Experimental Autoimmune Encephalomyelitis.2017
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi
- Organizer
  International Gap Junction Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Oligodendroglial Cx47 mediates myelin protective effects and plays a role in suppressing infiltration of inflammatory cells in autoimmune encephalomyelitis.2017
- Author(s)
  Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Hayato Une, Yiwen Cui, Jun-ichi Kira
- Organizer
  第29回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis.2017
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi
- Organizer
  The 142nd American Neurological Association Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Elucidation of pathomechanistic effect toward central nervous system (CNS) demyelinating disorders by altered function of gap junction-consisting protein “connexins”2017
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi.
- Organizer
  グリアアセンブリ第5回冬のシンポジウム
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] "Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis"2017
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi
- Organizer
  the 142nd American Neurological Association Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] "Astroglial (Cx30, Cx43) and oligodendroglial (Cx47) connexins modulate acute and chronic experimental autoimmune encephalomyelitis (EAE) "2017
- Author(s)
  "Ryo Yamasaki, Fang Mei, Hayato Une, Zhao Yinan, Hiroo Yamaguchi, Jun-ichi Kira "
- Organizer
  The 4th MS summer college 2017
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Experimental autoimmune encephalomyelitis is ameliorated in mice with gray matter astroglia-specific inducible connexin 43 knock-out.2017
- Author(s)
  Hayato Une, Hiroo Yamaguchi, Yinan Zhao, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, Ryo Yamasaki, Jun-ichi Kira
- Organizer
  XXIII World Congress of Neurology (WCN2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] "Astroglial and Oligodendroglial Connexins Differentially Influence Both Acute and Chronic Progressive Experimental Autoimmune Encephalomyelitis "2017
- Author(s)
  Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi
- Organizer
  "International Gap Junction Conference Glasgow 2017 "
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Astroglial connexin 30 deletion leads to hypersensitivity in a MPTP mouse model of Parkinson’s disease2017
- Author(s)
  Atsushi Fujita, 〇Hiroo Yamaguchi, Ryo Yamasaki, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira
- Organizer
  XXIII World Congress of Neurology（WCN2017）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] "Oligodendroglia-specific Connexin 47 deletion induced relapse-remitting EAE model mice"2017
- Author(s)
  "Ryo Yamasaki MD, PhD, Yinan Zhao, MD, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD."
- Organizer
  "10th PACTRIMS Ho Chi Minh City, Vietｎam"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Connexin 30 欠損マウスにおける慢性進行期EAEの軽症化2017
- Author(s)
  山﨑亮, 方梅, 李広瑞, 藤田篤史, 宇根隼人, 山口浩雄, 吉良潤一
- Organizer
  第29回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Oligodendroglial Cx47 mediates myelin protective effects and plays a role in suppressing infiltration of inflammatory cells in autoimmune encephalomyelitis2017
- Author(s)
  "Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Hayato Une, Yiwen Cui, Jun-ichi Kira "
- Organizer
  The 29th Annual Meeting of the Japanese Society Neuroimmunology
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Elucidation of pathophysiology of glial dysfunction in neurological/psychiatric disorders.2017
- Author(s)
  Jun-ichi Kira, Mitsuru Watanabe, Ryo Yamasaki, Takuya Matsushita, Hiroo Yamaguchi, Katsuhisa Masaki, Atsushi Fujita, Hayato Une, Mei Fang, Takayuki Fujii, Shintaro Hayashida, Ban-yu Saitoh, Wataru Shiraishi, Yinan Zhao, Ulfa Camelia Indiasari
- Organizer
  Glial disorders
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Connexin 30 欠損マウスにおける慢性進行期EAEの軽症化2017
- Author(s)
  "山﨑　亮、方　梅、李　広瑞、藤田篤史、宇根隼人、山口浩雄、吉良潤一 "
- Organizer
  第29回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09694
[Presentation] Experimental autoimmune encephalomyelitis in mice with induced conditional connexin 43 knock-out (Cx43cKO)2016
- Author(s)
  Hayato Une ,Hiroo Yamaguchi, Yinan Zhao,Koji Shinoda,Katsuhisa Masaki, Magdalena Gotz ,Ryo Yamasaki, Jun-ichi Kira
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-16H02657
[Presentation] Experimental Autoimmune Encephalomyelitis (EAE) is Ameliorated in Mice with Gray Matter (GM) Astrocyte- Specific Inducible Conditional Connexin 43 Knock-Out (Cx43cKO)2016
- Author(s)
  Hayato Une, Hiroo Yamaguchi, Yinan Zhao, Koji Shinoda, Katsuhisa Masaki, Magdalena Gotz, Ryo Yamasaki, and Jun- ichi Kira
- Organizer
  9th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2016-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02657

1. Masaki Katsuhisa (90612903)

# of Collaborated Projects: 11 results

# of Collaborated Products: 53 results
2. Yamasaki Ryo (10467946)

# of Collaborated Projects: 11 results

# of Collaborated Products: 76 results
3. Matsuse Dai (70596395)

# of Collaborated Projects: 9 results

# of Collaborated Products: 66 results
4. KIRA Jun-ichi (40183305)

# of Collaborated Projects: 8 results

# of Collaborated Products: 46 results
5. 渡邉充 (30748009)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
6. Kamada Takashi (70614460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. Shigeto Hiroshi (50335965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 松下拓也 (00533001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 雑賀徹 (00744880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
10. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUZUKI Satoshi (90294917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Ohyagi Yasumasa (30301336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Asai Hirohide (50510210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高瀬敬一郎 (00467903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 上原平 (30631585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 橋口公章 (80448422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本健 (60274528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 篠田紘司 (70747998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. 藤井敬之 (30822481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 立石貴久 (50423546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 緒方英紀 (90778838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 立川正憲 (00401810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 竹内英之 (30362213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 今村友裕 (30725122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Maimaitijiang Guzailiayi (60887107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. CHATANI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SHIMMURA Mitsunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 松岡悠太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 磯部紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Hiroo 山口 浩雄

YAMAGUCHI Hiroo 山口 浩雄

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

単一細胞RNA解析による多系統萎縮症増悪性ミクログリア亜群の同定と同細胞標的療法Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of primary-progressive multiple sclerosis (PPMS)/multiple system atrophy (MSA) mice modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Yamaguchi Hiroo 山口浩雄

YAMAGUCHI Hiroo 山口浩雄