Maeda Takahiro 前田高宏

… Alternative Names

Takahiro Maeda 前田高宏

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Researcher Number	00791972
Other IDs	https://orcid.org/0000-0003-4530-6460
Affiliation (Current)	2024: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 九州大学, 医学研究院, 教授 2017 – 2019: 九州大学, 大学病院, 准教授
Review Section/Research Field	Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Broad Section I / Hematology Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator CRISPR/Cas9 / 急性骨髄性白血病 / 急性リンパ性白血病 / AML / CRISPR / 白血病 / 機能的ジェノミックス / PROTAC / 機能ジェノミクス / BCL2 … More / TP53 / ALL / 急性白血病 / ゲノム編集 / プレmRNAプロセッシング / 分化誘導療法 / CRISPR/Cas9スクリーニング / PAICS / DCPS … More Except Principal Investigator クローン性造血 / 炎症性腸疾患 / 脊椎関節炎 / 巨細胞性動脈炎 / 加齢性クローナル造血 / 成人スチル病 / ベーチェット病 / がん微小環境 / システイン / トランスフェリン / PDXマウス / 白血病 / EBV / 劇症型NK白血病 / Epstein Bar virus / アグレッシブNK白血病 / DDX41 / HAVCR2 / 悪性リンパ腫 / 体細胞変異 / 胚細胞変異 / 急性骨髄性白血病 / 体細胞性変異 / 胚細胞性変異 / ゲノム解析 / 骨髄異形成症候群 / 発作性夜間血色素尿症 / 再生不良性貧血 / 骨髄不全症候群 Less

自己免疫疾患における加齢性クローナル造血の関連についての検討
- Principal Investigator
  
  小野伸之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyushu University
Development of novel therapeutic strategies for therapy-refractory leukemiaPrincipal Investigator
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Kyushu University
Identifying molecular mechanisms underlying treatment-refractory leukemia and their targeting strategiesPrincipal Investigator
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
Analysis of tumor microenvironment in aggressive NK leukemia
- Principal Investigator
  
  Kotani Ai
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokai University
Clinical application of germline and somatic mutations in bone marrow failure syndromes.
- Principal Investigator
  
  牧島秀樹
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyoto University
Identification of novel targets for leukemia therapy using genome-wide CRISPR/Cas9 screensPrincipal Investigator
- Principal Investigator
  
  Takahiro Maeda
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University

All 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis2019
- Author(s)
  33.Sher F, Hossain M, Seruggia D, Schoonenberg V.A.C., Yao Q, Cifani P, Dassama L.M.K., Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver M.C., Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE.
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 7 Pages: 1149-1159
- DOI
  10.1038/s41588-019-0453-4
- Data Source
  KAKENHI-PROJECT-17H01567
[Journal Article] DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways and protein complexes from CRISPR screens2018
- Author(s)
  Canver Matthew C、Bauer Daniel E、Maeda Takahiro、Pinello Luca
- Journal Title
  
  Bioinformatics
  
  Volume: 5 Issue: 11 Pages: 00-00
- DOI
  10.1093/bioinformatics/bty913
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Journal Article] Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS.2018
- Author(s)
  Sugio T, Miyawaki K, Kato K, Sasaki K, Yamada K, Iqbal J, Miyamoto T, Ohshima K, Maeda T, Miyoshi H, Akashi K.
- Journal Title
  
  Blood Advances
  
  Volume: 2 Issue: 17 Pages: 2242-2252
- DOI
  10.1182/bloodadvances.2018018754
- NAID
  40021890654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19565, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-16K09875
[Journal Article] Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.2018
- Author(s)
  Yamauchi T, et al.
- Journal Title
  
  Cancer Cell.
  
  Volume: 33 Issue: 3 Pages: 386-400
- DOI
  10.1016/j.ccell.2018.01.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-15J10130, KAKENHI-PROJECT-17K15042
[Journal Article] Molecular pathogenesis of disease progression in MLL-rearranged AML.2018
- Author(s)
  Kotani S, Yoda A, Kon A, Kataoka K, Ochi Y, Shiozawa Y, Hirsch C, Takeda J, Ueno H, Yoshizato T, Yoshida K, Nakagawa MM, Nannya Y, Kakiuchi N, Yamauchi T, Aoki K, Shiraishi Y, Miyano S, Maeda T, Maciejewski JP, Takaori-Kondo A, Ogawa S, Makishima H.
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 3 Pages: 612-624
- DOI
  10.1038/s41375-018-0253-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16084, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-16H05338, KAKENHI-PROJECT-17H04990, KAKENHI-PROJECT-17J05245, KAKENHI-PROJECT-17K19595, KAKENHI-PROJECT-19H01053
[Journal Article] CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis2018
- Author(s)
  Schoonenberg Vivien A. C.、Cole Mitchel A.、Yao Qiuming、Macias-Trevino Claudio、Sher Falak、Schupp Patrick G.、Canver Matthew C.、Maeda Takahiro、Pinello Luca、Bauer Daniel E.
- Journal Title
  
  Genome Biology
  
  Volume: 19 Issue: 1 Pages: 00-00
- DOI
  10.1186/s13059-018-1563-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis.2017
- Author(s)
  K. Miyawaki. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi
- Journal Title
  
  Blood
  
  Volume: 印刷中 Issue: 25 Pages: 3332-3343
- DOI
  10.1182/blood-2016-09-741611
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-15H04859, KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-17H01567, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-15K15365, KAKENHI-PROJECT-16K19578
[Patent] Identification of 131 Acute Myeloid Leukemia (AML) essential genes2018
- Inventor(s)
  Maeda T, Yamauchi T, MaedaM
- Industrial Property Rights Holder
  Maeda T, Yamauchi T, MaedaM
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H01567
[Patent] DCPS as a target for Acute Myeloid Leukemia2017
- Inventor(s)
  Maeda T, Yamauchi T, MaedaM
- Industrial Property Rights Holder
  Maeda T, Yamauchi T, MaedaM
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] Genome-wide CRISPR screen identifies PAICS, and enzyme involved in de novo purine synthesis, as a potential target for AML therapy.2019
- Author(s)
  Yamauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T
- Organizer
  FASEB: The Hematologic Malignancies Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] CRISPR-Cas9 screen identifies XPO7 as a potential therapeutic target for TP53-mutated AML.2019
- Author(s)
  42.SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
- Organizer
  61th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] CRISPR-Cas9 screen identifies Me2, a mitochondrial malic enzyme, as a molecule relevant for MCL1 inhibitor resistance2019
- Author(s)
  Nakao F, Yamauchi T, SembaY, Nogami J, Akashi K and Maeda T.
- Organizer
  FASEB: The Hematologic Malignancies Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] CRISPR-Cas9 screen identifies Me2, a mitochondrial malic enzyme, as a molecule relevant for MCL1 inhibitor resistance in AML.2019
- Author(s)
  Nakao F, Yamauchi T, SembaY, Nogami J, Akashi K and Maeda T.
- Organizer
  61th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML2019
- Author(s)
  SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
- Organizer
  Society of Hematologic Oncology (SOHO) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] Genome-wide CRISPR screen identifies PAICS, an enzyme involved in de novo purine synthesis, as a potential target for AML therapy2019
- Author(s)
  amauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T.
- Organizer
  Society of Hematologic Oncology (SOHO) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML2019
- Author(s)
  34.SembaY, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
- Organizer
  FASEB: The Hematologic Malignancies Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] PAICS, a de novo purine synthetic enzyme, is a novel target for AML therapy.2019
- Author(s)
  Yamauchi T, Miyawaki K, Semba Y, Nakao F, Nogami J, Sugio T, Sasaki K, Canver MC, Osborne S, Pinello L, Taylor D, Bauer DR, Akashi K, Maeda T.
- Organizer
  61th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] PAICS inhibition is a potential therapeutic strategy for MYC-positive DLBCL2019
- Author(s)
  Miyawaki K, Yamauchi T, SugioT, Sasaki K, Miyoshi H, Osborne S, Taylor D, Ohshima K, Kato K, Maeda T, Akashi K
- Organizer
  61th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] PAICS inhibition is a potential therapeutic strategy for MYC-positive aggressive DLBCL2019
- Author(s)
  Miyawaki K, Yamauchi T, SugioT, Sasaki K, Miyoshi H, Osborne S, Taylor D, Ohshima K, Kato K, Maeda T, Akashi K
- Organizer
  Society of Hematologic Oncology (SOHO) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] Leukemia-specific dependence on a nuclear pre-mRNA processing pathway regulated by the DCPS decapping enzyme. Novel insights into nuclear events in cancer.2018
- Author(s)
  Takahiro Maeda
- Organizer
  Novel insights into nuclear events in cancer, Singapore
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01567
[Presentation] Identifying novel targets for leukemia therapy using the CRISPR/Cas9 gene-editing tool2018
- Author(s)
  Takahiro Maeda
- Organizer
  Japanese Cancer Association Annual Meeting, Osaka
- Invited
- Data Source
  KAKENHI-PROJECT-17H01567

1. 山内拓司 (20796213)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 野上順平 (60801751)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 増田豪 (70383940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 仙波雄一郎 (90816787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Kotani Ai (00517477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菊繁吉謙 (40619706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 牧島秀樹 (40402127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 村松秀城 (00572570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮崎泰司 (40304943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 半田寛 (90282409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小野伸之 (00336025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 江里口芳裕 (70552016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KATO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 赤司浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 宮脇恒太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 宮本敏浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 昆彩奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maeda Takahiro 前田 高宏

Takahiro Maeda 前田 高宏

Research Projects

Research Products

Co-Researchers

自己免疫疾患における加齢性クローナル造血の関連についての検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategies for therapy-refractory leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifying molecular mechanisms underlying treatment-refractory leukemia and their targeting strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of tumor microenvironment in aggressive NK leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical application of germline and somatic mutations in bone marrow failure syndromes.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel targets for leukemia therapy using genome-wide CRISPR/Cas9 screensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways and protein complexes from CRISPR screens2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular pathogenesis of disease progression in MLL-rearranged AML.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis.2017

Author(s)

Journal Title

DOI

Data Source

[Patent] Identification of 131 Acute Myeloid Leukemia (AML) essential genes2018

Inventor(s)

Industrial Property Rights Holder

Maeda Takahiro 前田高宏

Takahiro Maeda 前田高宏