Hirunagi Tomoki 蛭薙智紀

Researcher Number	00927527
Other IDs
Affiliation (Current)	2025: 名古屋大学, 高等研究院(医), 特任助教
Affiliation (based on the past Project Information) *help	2025: 名古屋大学, 高等研究院(医), 特任助教 2022 – 2024: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related
Keywords	Principal Investigator 超早期病態 / 球脊髄性筋萎縮症 / ポリグルタミン病 / 超早期治療 / 核酸医薬 / シナプス関連遺伝子 / RAN翻訳 / 細胞非自律性メカニズム Except Principal Investigator 球脊髄性筋萎縮症 / 運動ニューロン疾患 … More / 神経変性疾患 / 核酸医薬 / 運動ニューロン / ポリグルタミン / 核酸 / 脊髄小脳失調症 / siRNA / ロングリードシークエンス / リバーストランスレーショナルリサーチ / スプライシング / 軸索 / 軸索異常 / 脊髄性筋萎縮症 / イオンチャンネル / 転写障害 / 早期病態 / エンドソーム / 筋萎縮性側索硬化症 / シングルセル解析 / 胎児 / マルチモーダル解析 / オリゴデンドロサイト / 神経変性 / タンパク質凝集体 / シヌクレイン / タンパク質凝集 / 凝集タンパク質 / アンチセンス核酸 / 低分子干渉RNA Less

The development of therapies targeting neurodegenerative factors for motor neuron disease
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Development of novel nucleic acid therapy for polyglutamine disease
- Principal Investigator
  
  勝野雅央
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
ポリグルタミン病の超早期病態における非細胞自律性メカニズムの解明Principal Investigator
- Principal Investigator
  
  蛭薙智紀
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Development of next-generation antisense therapeutics for neurological diseases
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
- Principal Investigator
  
  勝野雅央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Therapeutic development against protein aggregation
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Understanding of early axonal pathology in motor neuron diseases
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
The pathogenesis of neurodegeneration in the very early stage of polyglutamine disease and the development of nucleic acid therapy in polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  Hirunagi Tomoki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy.2025
- Author(s)
  Iida M, Sahashi K, Hirunagi T, Sakakibara K, Maeda k, Iguchi Y, Li J, Ogura Y, Iizuka M, Akashi T, Hinohara K, Sugio S, Wake H, Nakatochi M, Katsuno M
- Journal Title
  
  JCI Insight.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00420
[Journal Article] Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.2024
- Author(s)
  Hirunagi T, Nakatsuji H, Sahashi K, Yamamoto M, Iida M, Tohnai G, Kondo N, Yamada S, Murakami A, Noda S, Adachi H, Sobue G, Katsuno M.
- Journal Title
  
  J Cachexia Sarcopenia Muscle
  
  Volume: 15 Issue: 1 Pages: 159-172
- DOI
  10.1002/jcsm.13344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06976, KAKENHI-PROJECT-22K15705, KAKENHI-PROJECT-23H00420, KAKENHI-PROJECT-22K19489, KAKENHI-PROJECT-22K15706
[Journal Article] Dysregulation of Aldh1a2 underlies motor neuron degeneration in spinal muscular atrophy2023
- Author(s)
  Kataoka Mayumi、Sahashi Kentaro、Tsujikawa Koyo、Takeda Jun-ichi、Hirunagi Tomoki、Iida Madoka、Katsunoa Masahisa
- Journal Title
  
  Neuroscience Research
  
  Volume: - Pages: 58-65
- DOI
  10.1016/j.neures.2023.04.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20686, KAKENHI-PROJECT-22K15705, KAKENHI-PROJECT-22K19489, KAKENHI-PROJECT-22K15706
[Journal Article] Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy2022
- Author(s)
  Ogura Yosuke、Sahashi Kentaro、Hirunagi Tomoki、Iida Madoka、Miyata Takaki、Katsuno Masahisa
- Journal Title
  
  Cell Death & Disease
  
  Volume: 13 Issue: 7 Pages: 601-601
- DOI
  10.1038/s41419-022-05001-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15705, KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-21H02656, KAKENHI-PROJECT-21K20686, KAKENHI-PUBLICLY-21H00363, KAKENHI-PROJECT-22K19489, KAKENHI-PROJECT-22K15706
[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022
- Author(s)
  Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y.
- Journal Title
  
  Mov Disord.
  
  Volume: 37 Issue: 10 Pages: 2075-2085
- DOI
  10.1002/mds.29162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07424, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-21K19443, KAKENHI-PROJECT-22K15706
[Presentation] Single cell analysis reveals oligodendrocyte heterogeneity in spinal and bulbar muscular atrophy2023
- Author(s)
  飯田円, 佐橋健太郎, 蛭薙智紀, 榊原健二, 前田憲多郎, 紅朋浩, 日野原邦彦, 勝野雅央
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23H00420
[Presentation] Polyglutamine-mediated neurotoxicity in the neonatal stage of spinal and bulbar muscular atrophy2023
- Author(s)
  Tomoki Hirunagi, Kentaro Sahashi, Madoka Iida, and Masahisa Katsuno.
- Organizer
  Gordon Research Conference CAG Triplet Repeat Disorders.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15706
[Presentation] Polyglutamine-mediated neurotoxicity in developmental stages of spinal and bulbar muscular atrophy2023
- Author(s)
  Tomoki Hirunagi
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15706
[Presentation] 球脊髄性筋萎縮症におけるアンドロゲン依存的な軸索脆弱性へのMID1の関与2022
- Author(s)
  小椋陽介, 佐橋健太郎, 蛭薙智紀飯田円, 宮田卓樹, 勝野雅央
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19489
[Presentation] 運動による骨格筋AMPKシグナルの活性化は、ポリグルタミン蛋白の凝集体形成による神経筋変性を抑制する2022
- Author(s)
  蛭薙智紀, 中辻秀朗, 佐橋健太郎, 山本幹泰, 飯田円, 藤内玄規, 近藤直英, 山田晋一郎, 村上あゆ香, 野田成哉, 足立弘明, 祖父江元, 勝野雅央
- Organizer
  第16回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-22K15706
[Presentation] Exercise-induced Ampk activation ameliorates polyQ-mediated neuromuscular degeneration in SBMA mice2022
- Author(s)
  蛭薙智紀，中辻秀朗，佐橋健太郎，藤内玄規，飯田円，山田晋一郎，村上あゆ香，野田成哉, 勝野雅央
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15706
[Presentation] 神経特異的タンパク質によるリピート病における細胞変性機序2022
- Author(s)
  佐橋健太郎, 小椋陽介, 蛭薙智紀, 飯田円, 宮田卓樹, 勝野雅央
- Organizer
  第16回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-22K19489

1. Sahashi Kentaro (90710103)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. 勝野雅央 (50402566)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
3. 井口洋平 (80790659)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 横井聡 (30815460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 阿部洋 (80415067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 浅沼浩之 (20282577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 飯田円 (40815437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 辻河高陽 (60880862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ADACHI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. KAHORI Shiba

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirunagi Tomoki 蛭薙 智紀

Research Projects

Research Products

Co-Researchers

The development of therapies targeting neurodegenerative factors for motor neuron disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel nucleic acid therapy for polyglutamine disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ポリグルタミン病の超早期病態における非細胞自律性メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation antisense therapeutics for neurological diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic development against protein aggregation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of early axonal pathology in motor neuron diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The pathogenesis of neurodegeneration in the very early stage of polyglutamine disease and the development of nucleic acid therapy in polyglutamine diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy.2025

Author(s)

Journal Title

Data Source

[Journal Article] Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulation of Aldh1a2 underlies motor neuron degeneration in spinal muscular atrophy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Single cell analysis reveals oligodendrocyte heterogeneity in spinal and bulbar muscular atrophy2023

Author(s)

Organizer

Data Source

Hirunagi Tomoki 蛭薙智紀

[Presentation] 神経特異的タンパク質によるリピート病における細胞変性機序2022