Hashimoto Kenji 橋本謙二

… Alternative Names

HASHIMOTO Kenji 橋本謙二

橋本謙二ハシモトケンジ

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Researcher Number	10189483
Other IDs	https://orcid.org/0000-0002-8892-0439
Affiliation (Current)	2025: 千葉大学, 社会精神保健教育研究センター, 特任教授
Affiliation (based on the past Project Information) *help	2005 – 2023: 千葉大学, 社会精神保健教育研究センター, 教授 2008: 千葉大学, 社会精神保健教育センター, 教授 2005: 千葉大学, 大学院・医学研究院, 教授 2002 – 2004: 千葉大学, 大学院・医学研究院, 助教授 1994: 国立精神・神経センター, 精神保健研究所・薬物依存研究部, 研究員
Review Section/Research Field	Principal Investigator Psychiatric science / Biological Sciences / Biological Sciences / Psychiatric science / Medium-sized Section 10:Psychology and related fields / Basic Section 52030:Psychiatry-related / Transformative Research Areas, Section (III) / 医薬分子機能学 Except Principal Investigator Psychiatric science / Basic Section 10030:Clinical psychology-related … More / Biological Sciences / Clinical psychology / Pathological medical chemistry / Radiation science / Neurochemistry/Neuropharmacology / Psychiatric science Less
Keywords	Principal Investigator 統合失調症 / NMDA受容体 / うつ病 / ストレス / 脳・神経疾患 / D型セリン / レジリエンス / 炎症 / 脳由来神経栄養因子 / 脳神経疾患 … More / D型アミノ酸 / 迷走神経 / 脳ー腸相関 / 腸-脳相関 / 腸内細菌 / 認知機能障害 / セリンラセマーゼ / グルタミン酸 / グリア細胞 / 代謝物 / 予防 / 脳-腸相関 / 栄養学 / 双極性障害 / ニコチン受容体 / スパイン / 神経科学 / ケタミン / ＮＭＤＡ受容体 / グルタミン酸受容体 / 動物モデル / D型アミノ酸酸化酵素 / グリシントランスポーター / 死後脳 / 脳 / シグマ受容体 / うう病 / 抗うつ作用 / 光学異性体 / 抗うつ効果 / 予防効果 / 骨密度 / アールケタミン / ミエリン / 抗うつ薬 / ストレス性精神障害 / うつ症状 / RNA-seq解析 / 巨核球 / BDNF / iPS細胞 / 自閉症 / 酸化的ストレス / ミトコンドリア / クエン酸回路 / バイオマーカー / Fluvoxamine / Cognitive deficits / Glutamate / Tropisetron / Sigma Receptor / Nicotine Receptor / Schizophrenia / NMDA receptor / フャンサイクルジン / フルボキサミン / トロピセトロン / 精神疾患 / グルタミン酸神経系 / TrkB受容体 / 薬理学 / Dセリン / ピルビン酸 / 脳疾患 / Ｄ型アスパラギン酸 / Ｄ型セリン / Ｄ型アミノ酸 / D 型アスパラギン酸 / D 型セリン / D 型アミノ酸 / D型サイクロセリン / D型アラニン / 薬物依存 / 覚せい剤 / 驚愕反応 / 脳内透析法 / D型アミノ酸分解酵素 / グルタミン / グリア / グリシン / ニューロン / 熱ストレス蛋白質 / 神経毒性 … More Except Principal Investigator 統合失調症 / 思春期 / 双極性障害傾向 / PTSD / ADHD / fMRI / うつ病 / 脳・神経 / 神経栄養因子 / 抑うつ / 行動遺伝学 / 抑うつ傾向 / 児童期 / マイクロエンドフェアタイプ / 神経科学科学 / 躁うつ病 / 双極性障害 / 気分障害 / マイクロエンドフェノタイプ / 精神病態 / 精神疾患 / 神経科学 / 認知機能 / 縦断調査 / 自己制御 / CBT / 精神病理学 / ストレス科学 / 心理療法 / 認知行動療法 / Mastermind / Notchシグナル / 定量分析 / 可視化 / 分子イメージング用リガンド / 脳精神・神経疾患 / 分子イメージング / 動物 / 放射性薬剤 / PDE10A / 脳 / 活性型ミクログリア / PET / 活性ミクログリア / 精神薬理学 / NMDA / ドーパミン / 自閉症 / P50 抑制 / プレパルス抑制 / 感覚ゲート機構 / グルタミン酸 / 中間表現型 / 神経画像 / 遺伝子 / ミッドカイン / 海馬 / サイトカイン / midkine Less

Understanding of biological mechanisms of resilience based on gut-brain axisPrincipal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 10:Psychology and related fields
- Research Institution
  Chiba University
Constructive understanding of stress-related psychiatric disorders by brain-gut-microbiota axisPrincipal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Study of stress-related psychiatric disorders based on brain-gut axis via vagus nervePrincipal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Chiba University
Study of molecular mechanisms underlying antidepressant actions of (R)-ketaminePrincipal Investigator
- Principal Investigator
  
  Hashimoto Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Chiba University
思春期の抑うつ・双極性障害傾向とADHDとの併存の問題に関する発達心理学的研究
- Principal Investigator
  
  田中麻未
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  Teikyo University
  Chiba University
Transomics modeling using iPSC of bipolar disorderPrincipal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Problem of coexisting bipolarity and ADHD in childhood and adolescence
- Principal Investigator
  
  TANAKA Mami
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  Chiba University
Prevention of schizophrenia based on Keap1-Nrf2 systemPrincipal Investigator
- Principal Investigator
  
  Hashimoto Kenji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
統合失調症のモデル動物におけるＢＤＮＦ－ＴｒｋＢシグナル系の役割Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Relationship between bipolarity and self-regulation in adolescence
- Principal Investigator
  
  Tanaka Mami
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical psychology
- Research Institution
  Chiba University
Metabolomics analysis of CSF from bipolar disorder patientsPrincipal Investigator
- Principal Investigator
  
  Kenji Hashimoto
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
統合失調症のモデル動物におけるＢＤＮＦ－ＴｒｋＢシグナル系の役割Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Molecular mechanism of inflammation-induced depressionPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO KENJI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Microendophenotype of psychiatric disorders by glutamatergic signalPrincipal Investigator
- Principal Investigator
  
  Kenji Hashimoto
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Involvement of a co-factor of Notch signaling, Mastermind, into Schizophrenia
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
Unraveling the micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels
- Principal Investigator
  
  Kida Satoshi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Agriculture
核医学手法による生体脳内ホスホジエステラーゼの可視化と定量法の創出
- Principal Investigator
  
  呉勁
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Study of synthesis and metabolism of D-serine in the brainPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Kenji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Molecular mechanism of D-serine for pathophysiology of schizophreniaPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
うつ病の病態発生機序と活性型ミクログリアの関連に関するPETを用いた研究
- Principal Investigator
  
  関根吉統
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Study on Molecular Pathophysiology of SchizophreniaPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Kenji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
統合失調症の病態におけるD型アラニンの役割に関する研究Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
グリア-ニューロン間におけるD型セリンの分子機構解明Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Integrative approach toward understanding impaired glutamatergic neurotransmission in schizophrenia
- Principal Investigator
  
  KASAI Kiyoto
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The University of Tokyo
Sensory gating deficits in schizophrenia and midkine deficiency
- Principal Investigator
  
  SHIMIZU Eiji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Chiba University
Study on Molecular Pathophysiology of SchizophreniaPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
Effects of prolonged exposure on brain activation of a PTSD patients using script driven fMRI
- Principal Investigator
  
  KIM Yoshiharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
グリア-ニューロン間におけるD型セリンの分子機構解明Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ミッドカイン欠損による海馬発達障害と精神分裂病の生物学的脆弱性との関連
- Principal Investigator
  
  SHIMIZU Eiji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Chiba University
中枢神経系におけるシグマ受容体とNMDA受容体の相互作用に関する研究Principal Investigator
- Principal Investigator
  
  橋本謙二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Center of Neurology and Psychiatry

[Book] New Rapid-acting Antidepressants2021
- Author(s)
  Kai Zhang and Kenji Hashimoto
- Total Pages
  149
- Publisher
  Springer
- ISBN
  9783030797898
- Data Source
  KAKENHI-PROJECT-21H02846
[Book] NMDA Receptors2017
- Author(s)
  Hashimoto K
- Total Pages
  148
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-24116006
[Book] Melatonin and Neuroprotective Agents in Neuropsychiatric Disorders.2015
- Author(s)
  Hashimoto K
- Publisher
  Spｒinger Publisher
- Data Source
  KAKENHI-PLANNED-24116006
[Book] SSRI: Pharmacology, Mechanisms of Action and Potential Side Effects.2015
- Author(s)
  Albayrak Y, Hashimoto K.
- Publisher
  Nova Publsihers
- Data Source
  KAKENHI-PLANNED-24116006
[Book] The Handbook of Behavior, Diet and Nutrition2011
- Author(s)
  K.Hashimoto
- Publisher
  Springer Publishers In press
- Data Source
  KAKENHI-PROJECT-22390220
[Book] The Handbook of Behavior, Diet and Nutrition2010
- Author(s)
  Hashimoto K.
- Publisher
  Food coloring, sodium benzoate preservative and D-serine : implication for behavior(In press)
- Data Source
  KAKENHI-PROJECT-19390301
[Book] D-Serine and Schizophrenia.(In : Diamino Amino Acids, ed. Schafer HA, and Wohlbier LM)2010
- Author(s)
  Hashimoto, K.
- Publisher
  Nova Publishers(in press)
- Data Source
  KAKENHI-PROJECT-19390301
[Book] Glycine transporter inhibitors as therapeutic agents for schizophrenia(In : Frontiers in CNS Drug Discovery (Volume 1), ed. Choudhary, M. I. and Rahman A.)2010
- Author(s)
  Hashimoto, K.
- Publisher
  Bentham Science Publishers(in press)
- Data Source
  KAKENHI-PROJECT-19390301
[Book] Food coloring, sodium benzoate preservative and D-serine : Implication for behavior(In : The Handbook of Behavior, Diet and Nutrition, ed. Preedy, V. R.)2010
- Author(s)
  Hashimoto, K.
- Publisher
  Springer Publishers(in press)
- Data Source
  KAKENHI-PROJECT-19390301
[Book] D-Amino acids2008
- Author(s)
  Hashimoto K.
- Publisher
  Nova Publisher Inc.(未定)
- Data Source
  KAKENHI-PROJECT-18053004
[Journal Article] Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine2024
- Author(s)
  Huang C, Wu Z, Wang D, Qu Y, Zhang J, Jiang R, Xu X, Xu X, Wang Y, Liu H, He T, Liu C, Chen G, Yang JJ, Hashimoto K, Yang C.
- Journal Title
  
  Mol Psychiatry
  
  Volume: in pree Issue: 6 Pages: 1741-1753
- DOI
  10.1038/s41380-023-02288-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Depression-like phenotypes in mice following common bile duct ligation: Insights into the gut-liver-brain axis via the vagus nerve2024
- Author(s)
  Yang Y, Eguchi A, Mori C, Hashimoto K
- Journal Title
  
  Neurobiol Dis
  
  Volume: 192 Pages: 106433-106433
- DOI
  10.1016/j.nbd.2024.106433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Depression-like phenotypes in mice with hepatic ischemia/reperfusion injury: A role of gut-microbiota-liver-brain axis via vagus nerve2024
- Author(s)
  Yang Y, Eguchi A, Wan X, Mori C, Hashimoto K
- Journal Title
  
  J Affect Disord
  
  Volume: 345 Pages: 157-167
- DOI
  10.1016/j.jad.2023.10.142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] A role of gut-brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress2024
- Author(s)
  Ma L, Eguchi A, Liu G, Qu Y, Wan X, Murayama R, Mori C, Hashimoto K
- Journal Title
  
  Pharmacol Biochem Behav
  
  Volume: 238 Pages: 173736-173736
- DOI
  10.1016/j.pbb.2024.173736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?2024
- Author(s)
  Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: in press
- DOI
  10.1007/s00406-024-01770-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Comments to behavioral tests for antidepressant-like actions of (2R,6R)-hydroxynorketamine by Bonaventura et al2023
- Author(s)
  Chang L, Hashimoto K
- Journal Title
  
  Mol Psychiatry
  
  Volume: in press Issue: 1 Pages: 3-4
- DOI
  10.1038/s41380-022-01766-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress2023
- Author(s)
  Liu G, Ma L, Qu Y, Wan X, Xu D, Zhao M, Murayama R, Hashimoto K.
- Journal Title
  
  Pharmacol Biochem Behav
  
  Volume: 233 Pages: 173659-173659
- DOI
  10.1016/j.pbb.2023.173659
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Abnormal compositions of gut microbiota and metabolites are associated with susceptibility versus resilience in rats to inescapable electric stress2023
- Author(s)
  Wang X, Eguchi A, Fujita Y, Wan X, Chang L, Yang Y, Shan J, Qu Y, Ma L, Shirayama Y, Mori C, Yang J, Hashimoto K
- Journal Title
  
  J Affect Disord
  
  Volume: 331 Pages: 369-379
- DOI
  10.1016/j.jad.2023.03.073
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice2023
- Author(s)
  Ma L, Wang L, Qu Y, Wan X, Hashimoto K
- Journal Title
  
  Transl Psychiatry
  
  Volume: 13(1) Issue: 1 Pages: 269-269
- DOI
  10.1038/s41398-023-02564-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Neuroinflammation through the vagus nerve-dependent gut-microbiota-brain axis in treatment-resistant depression2023
- Author(s)
  Hashimoto K
- Journal Title
  
  Prog Brain Res
  
  Volume: 278 Pages: 61-77
- DOI
  10.1016/bs.pbr.2023.01.003
- ISBN
  9780323957786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Ketamine and its metabolites: Potential as novel treatments for depression2023
- Author(s)
  Hashimoto K, Chaki S
- Journal Title
  
  Neuropharmacology
  
  Volume: 230 Pages: 109492-109492
- DOI
  10.1016/j.neuropharm.2023.109492
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Ketamine and its metabolites: Potential as novel treatments for depression2023
- Author(s)
  Zhang K, Yao Y, Hashimoto K
- Journal Title
  
  Neuropharmacology
  
  Volume: 222 Pages: 109305-109305
- DOI
  10.1016/j.neuropharm.2022.109305
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Repeated use of 3,4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: A role of gut-microbiota-brain axis2023
- Author(s)
  Qu Y, Eguchi A, Wan X, Ma L, Chang L, Shan J, Yang Y, Mori C, Hashimoto K
- Journal Title
  
  Psychiatry Res
  
  Volume: 320 Pages: 115020-115020
- DOI
  10.1016/j.psychres.2022.115020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Beneficial effects of arketamine on the reduced bone mineral density in susceptible mice after chronic social defeat stress: Role of the gut-microbiota-bone-brain axis2023
- Author(s)
  Wan X, Eguchi A, Chang L, Mori C, Hashimoto K
- Journal Title
  
  Neuropharmacology
  
  Volume: 228 Pages: 109466-109466
- DOI
  10.1016/j.neuropharm.2023.109466
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PROJECT-21H02846, KAKENHI-PUBLICLY-21H00184
[Journal Article] Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain2023
- Author(s)
  Wang X, Eguchi A, Yang Y, Chang L, Wan X, Shan J, Qu Y, Ma L, Mori C, Yang J, Hashimoto K
- Journal Title
  
  Neurobiol Dis
  
  Volume: 176 Pages: 105951-105951
- DOI
  10.1016/j.nbd.2022.105951
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice2023
- Author(s)
  Qu Y, Chang L, Ma L, Wan X, Hashimoto K
- Journal Title
  
  Pharmacol Biochem Behav
  
  Volume: 222 Pages: 173500-173500
- DOI
  10.1016/j.pbb.2022.173500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Arketamine for cognitive impairment in psychiatric disorders2023
- Author(s)
  Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: in press Issue: 7 Pages: 1513-1525
- DOI
  10.1007/s00406-023-01570-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PROJECT-21H02846, KAKENHI-PUBLICLY-21H00184
[Journal Article] Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX56222022
- Author(s)
  Yang Y, Ishima T, Wan X, Wei Y, Chang L, Zhang J, Qu Y, Hashimoto K.
- Journal Title
  
  Eur Arch psychiatry Clin Neurosci
  
  Volume: 272(3) Issue: 3 Pages: 483-495
- DOI
  10.1007/s00406-021-01325-0
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05612
[Journal Article] A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model2022
- Author(s)
  Ma L, Wang L, Chang L, Shan J, Qu Y, Wang X, Fujita Y, Hashimoto K
- Journal Title
  
  Neuropharmacology
  
  Volume: 219 Pages: 109250-109250
- DOI
  10.1016/j.neuropharm.2022.109250
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential2022
- Author(s)
  Zhang X, Liu H, Hashimoto K, Yuan S, Zhang J
- Journal Title
  
  Crit Care
  
  Volume: 26(1) Issue: 1 Pages: 23-23
- DOI
  10.1186/s13054-022-04090-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis2022
- Author(s)
  Wan X, Eguchi A, Sakamoto A, Fujita Y, Yang Y, Qu Y, Hatano M, Mori C, Hashimoto K
- Journal Title
  
  Brain Behav Immun Health
  
  Volume: 27 Pages: 100573-100573
- DOI
  10.1016/j.bbih.2022.100573
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Effects of (R)-ketamine on reduced bone mineral density in ovariectomized mice: A role of gut microbiota2022
- Author(s)
  Wan X, Eguchi A, Fujita Y, Ma L, Wang X, Yang Y, Qu Y, Chang L, Zhang J, Mori C, Hashimoto K
- Journal Title
  
  Neuropharmacology
  
  Volume: 213 Pages: 109139-109139
- DOI
  10.1016/j.neuropharm.2022.109139
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PROJECT-21H02846
[Journal Article] Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring2022
- Author(s)
  Wei Y, Chang L, Liu G, Wang X, Yang Y, Hashimoto K
- Journal Title
  
  J Nutr Biochem
  
  Volume: 109 Pages: 109098-109098
- DOI
  10.1016/j.jnutbio.2022.109098
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice2022
- Author(s)
  Yang Y, Eguchi A, Wan X, Chang L, Wang X, Qu Y, Mori C, Hashimoto K
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 120 Pages: 110652-110652
- DOI
  10.1016/j.pnpbp.2022.110652
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Brain-spleen axis in health and diseases: A review and future perspective2022
- Author(s)
  Wei Y, Wang T, Liao L, Fan X, Chang L, Hashimoto K.
- Journal Title
  
  Brain Res Bull
  
  Volume: 182 Pages: 130-140
- DOI
  10.1016/j.brainresbull.2022.02.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00184, KAKENHI-PUBLICLY-21H05612
[Journal Article] Mental health during the COVID-19 pandemic, impact of childhood trauma in psychiatric disorders, and predictable biomarkers for bipolar disorder2022
- Author(s)
  Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 272(5) Issue: 5 Pages: 753-755
- DOI
  10.1007/s00406-022-01445-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Depression-like behaviors in mouse model of Sjogren's syndrome: A role of gut-microbiota-brain axis2022
- Author(s)
  Pu Y, He Y, Zhao X, Zhang Q, Wen J, Hashimoto K, Liu Y
- Journal Title
  
  Pharmacol Biochem Behav
  
  Volume: 219 Pages: 173448-173448
- DOI
  10.1016/j.pbb.2022.173448
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] 10.1016/j.neubiorev.2022.1047622022
- Author(s)
  Wang X, Yang J, Hashimoto K
- Journal Title
  
  Neurosci Biobehav Rev
  
  Volume: 139 Pages: 104762-104762
- DOI
  10.1016/j.neubiorev.2022.104762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PROJECT-21H02846, KAKENHI-PUBLICLY-21H00184
[Journal Article] Gut-microbiota-brain axis by bile acids in depression2022
- Author(s)
  Hashimoto K
- Journal Title
  
  Psychiatry Clin Neurosci.
  
  Volume: 76(7) Issue: 7 Pages: 281-281
- DOI
  10.1111/pcn.13370
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] (R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut-microbiota-brain axis2022
- Author(s)
  Wang X, Chang L, Wan X, Tan Y, Qu Y, Shan J, Yang Y, Ma L, Hashimoto K.
- Journal Title
  
  Neurobiol Dis
  
  Volume: 165 Pages: 105635-105635
- DOI
  10.1016/j.nbd.2022.105635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00184, KAKENHI-PROJECT-21H02846
[Journal Article] The role of hippocampal KCNQ2 channel in antidepressant actions of ketamine2022
- Author(s)
  Ma L, Hashimoto K
- Journal Title
  
  Neuron
  
  Volume: 110(14) Issue: 14 Pages: 2201-2203
- DOI
  10.1016/j.neuron.2022.05.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice2022
- Author(s)
  Ma L, Wang L, Chang L, Shan J, Qu Y, Wang X, Wan X, Fujita Y, Hashimoto K
- Journal Title
  
  Transl Psychiatry
  
  Volume: 12(1) Issue: 1 Pages: 417-417
- DOI
  10.1038/s41398-022-02192-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine2022
- Author(s)
  Ma L, Zhang J, Fujita Y, Qu Y, Shan J, Wan X, Wang X, Ishima T, Kobayashi K, Wang L, Hashimoto K.
- Journal Title
  
  Transl Psychaitry
  
  Volume: 12(1) Issue: 1 Pages: 27-27
- DOI
  10.1038/s41398-022-01803-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Ketamine: anesthetic, psychotomimetic, antidepressant, or anthelmintic?2022
- Author(s)
  Hashimoto K
- Journal Title
  
  Mol Psychiatry
  
  Volume: 27(8) Issue: 8 Pages: 3116-3118
- DOI
  10.1038/s41380-022-01587-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation2022
- Author(s)
  Pu Y, Zhang Q, Tang Z, Lu C, Wu L, Zhong Y, Chen Y, Hashimoto K, Luo Y, Liu Y
- Journal Title
  
  Transl Psychiatry
  
  Volume: 12(1) Issue: 1 Pages: 223-223
- DOI
  10.1038/s41398-022-01993-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Arketamine, a new rapid-acting antidepressant: A historical review and future directions2022
- Author(s)
  Zhang JC, Yao W, Hashimoto K
- Journal Title
  
  Neuropharmacology
  
  Volume: 218 Pages: 109219-109219
- DOI
  10.1016/j.neuropharm.2022.109219
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] A bibliometric analysis of research on (R)-ketamine from 2002 to 20212022
- Author(s)
  He T, Wang D, Wu Z, Huang C, Xu X, Xu X, Liu C, Hashimoto K, Yang C
- Journal Title
  
  Neuropharmacology
  
  Volume: 218 Pages: 109207-109207
- DOI
  10.1016/j.neuropharm.2022.109207
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis2022
- Author(s)
  Ma L, Zhang J, Fujita Y, Shinno-Hashimoto H, Shan J, Wan X, Qu Y, Chang L, Wang X, Hashimoto K
- Journal Title
  
  J Affect Disord
  
  Volume: 317 Pages: 156-165
- DOI
  10.1016/j.jad.2022.08.087
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence2022
- Author(s)
  Wan X, Eguchi A, Qu Y, Yang Y, Chang L, Shan J, Mori C, Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 272(7) Issue: 7 Pages: 1297-1309
- DOI
  10.1007/s00406-022-01437-1
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05612, KAKENHI-PUBLICLY-21H00184
[Journal Article] Brain-gut-microbiota axis in depression: A historical overview and future directions2022
- Author(s)
  Chang L, Wei Y, Hashimoto K.
- Journal Title
  
  Brain Res Bull
  
  Volume: 182 Pages: 44-56
- DOI
  10.1016/j.brainresbull.2022.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00184, KAKENHI-PUBLICLY-21H05612
[Journal Article] Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve2021
- Author(s)
  Wang S, Ishima T, Qu Y, Shan J, Chang L, Wei Y, Zhang J, Pu Y, Fujita Y, Tan Y, Wang X, Ma L, Wan X, Hammock BD, Hashimoto K
- Journal Title
  
  J Affect Disord
  
  Volume: 292 Pages: 565-573
- DOI
  10.1016/j.jad.2021.06.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00184, KAKENHI-PUBLICLY-21H05612
[Journal Article] Risk of neuropsychiatric disorders in offspring of COVID-19-infected pregnant women and nutritional intervention2021
- Author(s)
  Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 271 Issue: 2 Pages: 387-389
- DOI
  10.1007/s00406-020-01148-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor2021
- Author(s)
  Hashimoto K
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 271 Issue: 2 Pages: 249-258
- DOI
  10.1007/s00406-020-01231-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05203, KAKENHI-PROJECT-17H04243
[Journal Article] Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine2021
- Author(s)
  Yao W, Cao Q, Luo S, He L, Yang C, Chen J, Qi Q, Hashimoto K, Zhang JC.
- Journal Title
  
  Mol Psychiatry
  
  Volume: none Issue: 3 Pages: 1618-1629
- DOI
  10.1038/s41380-021-01377-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Journal Article] Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents2021
- Author(s)
  Yao W, Lin S, Su J, Cao Q, Chen Y, Chen J, Zhang Z, Hashimoto K, Qi Q, Zhang J.
- Journal Title
  
  Trans Psychiatry
  
  Volume: 11 Issue: 1 Pages: 140-140
- DOI
  10.1038/s41398-021-01261-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Current status of potential therapeutic candidates for the COVID-19 crisis2020
- Author(s)
  Zhang J, Xie B, Hashimoto K
- Journal Title
  
  Brain Behav Immun
  
  Volume: 87 Pages: 59-73
- DOI
  10.1016/j.bbi.2020.04.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05203, KAKENHI-PROJECT-17H04243
[Journal Article] Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase2020
- Author(s)
  Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wan D, Hwang SH, Hammock BD, Hashimoto K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 117 Issue: 21 Pages: 11753-11759
- DOI
  10.1073/pnas.1922287117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation2020
- Author(s)
  Fujita Y, Hashimoto K
- Journal Title
  
  Neuropsychopharmacol Rep
  
  Volume: 40 Issue: 3 Pages: 268-274
- DOI
  10.1002/npr2.12112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study.2020
- Author(s)
  Seki, R., Hashimoto, T., Tanaka, M., Sato, A., Kimura, H., Kimura, A., Handa, S., Kanahara, N., Okayama, J., Omoto, A., Endo, M., Osone, Y., Watanabe, H., Tanaka, H., Nakazato, M., Shozu, M., & Iyo, M.
- Journal Title
  
  Clinical Neuropsychopharmacology and Therapeutics
  
  Volume: 11 Issue: 0 Pages: 61-66
- DOI
  10.5234/cnpt.11.61
- NAID
  130007921985
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K03129
[Journal Article] Dietary intake of glucoraphanin prevents the reduction of dopamine transporter in the mouse striatum after repeated administration of MPTP2019
- Author(s)
  Pu Y, Qu Y, Chang L, Wang S, Zhang K, Ushida Y, Suganuma H, Hashimoto K
- Journal Title
  
  Neuropsychopharmacology Report
  
  Volume: 39 Issue: 3 Pages: 247-251
- DOI
  10.1002/npr2.12060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Recent advances in the eraly intervention in schizophrenia: future direction from preclinical findings.2019
- Author(s)
  Hashimoto K.
- Journal Title
  
  Current Psychiatry Reports
  
  Volume: 21 Issue: 8 Pages: 75-75
- DOI
  10.1007/s11920-019-1063-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation2019
- Author(s)
  Ma Min、Ren Qian、Yang Jun、Zhang Kai、Xiong Zhongwei、Ishima Tamaki、Pu Yaoyu、Hwang Sung Hee、Toyoshima Manabu、Iwayama Yoshimi、Hisano Yasuko、Yoshikawa Takeo、Hammock Bruce D.、Hashimoto Kenji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 14 Pages: 7083-7088
- DOI
  10.1073/pnas.1819234116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-17H04243, KAKENHI-PROJECT-17J03385, KAKENHI-PROJECT-19K08023, KAKENHI-PROJECT-20K20388, KAKENHI-PROJECT-18H03579
[Journal Article] Understanding the link between maternal infections and neurodevelopmental disorders in offspring: The role of abnormalities in metabolism of polyunsaturated fatty acids2019
- Author(s)
  Hashimoto Kenji
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 81 Pages: 4-5
- DOI
  10.1016/j.bbi.2019.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05203
[Journal Article] Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.2018
- Author(s)
  Zhang JC, Yao W, Dong C, Han M, Shirayama Y, Hashimoto K
- Journal Title
  
  Eur ARch psychiatry Clin Neurosci
  
  Volume: 268(8) Issue: 8 Pages: 865-870
- DOI
  10.1007/s00406-017-0848-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease2018
- Author(s)
  Ren Qian、Ma Min、Yang Jun、Nonaka Risa、Yamaguchi Akihiro、Ishikawa Kei-ichi、Kobayashi Kenta、Murayama Shigeo、Hwang Sung Hee、Saiki Shinji、Akamatsu Wado、Hattori Nobutaka、Hammock Bruce D.、Hashimoto Kenji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 25
- DOI
  10.1073/pnas.1802179115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K06535, KAKENHI-PROJECT-18K15463, KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-17H04243, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-18K15439
[Journal Article] Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation2018
- Author(s)
  Matsuura Akiko、Ishima Tamaki、Fujita Yuko、Iwayama Yoshimi、Hasegawa Shunsuke、Kawahara-Miki Ryouka、Maekawa Motoko、Toyoshima Manabu、Ushida Yusuke、Suganuma Hiroyuki、Kida Satoshi、Yoshikawa Takeo、Iyo Masaomi、Hashimoto Kenji
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2158-2158
- DOI
  10.1038/s41598-018-20538-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-17H06084, KAKENHI-PROJECT-15H02488, KAKENHI-PROJECT-17H04243, KAKENHI-PUBLICLY-17H05581, KAKENHI-PUBLICLY-17H05961, KAKENHI-PROJECT-18H03944, KAKENHI-PROJECT-17K19464, KAKENHI-PROJECT-15K09814
[Journal Article] Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective.2018
- Author(s)
  Hashimoto K
- Journal Title
  
  Front Pharmacol
  
  Volume: 9 Pages: 1182-1182
- DOI
  10.3389/fphar.2018.01182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04243
[Journal Article] Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation2017
- Author(s)
  Han M, Zhang JC, Huang XF, Hashimoto K.
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 15 Issue: 5 Pages: 479-483
- DOI
  10.1007/s00406-017-0802-1
- Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16F14711
[Journal Article] Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.2017
- Author(s)
  Balan S, Yamada K, Iwayama Y, Hashimoto T, Toyota T, Shimamoto C, Maekawa M, Takagai S, Wakuda T, Kameno Y, Kurita D, Yamada K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T
- Journal Title
  
  Schizophrenia Research
  
  Volume: 印刷中 Pages: 33-40
- DOI
  10.1016/j.schres.2017.01.003
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-15K09814, KAKENHI-PROJECT-16K10186
[Journal Article] Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression.2017
- Author(s)
  Shirayama Y, Hashimoto K.
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 267 Issue: 2 Pages: 177-182
- DOI
  10.1007/s00406-016-0718-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Reduction of dopamine D<sub>2/3</sub> receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.2017
- Author(s)
  Hashimoto K, Kakiuchi T, Ohba H, Nishiyama S, Tsukada H.
- Journal Title
  
  Eur Arch Psychiatry Clin Neurosci
  
  Volume: 267 Issue: 2 Pages: 173-176
- DOI
  10.1007/s00406-016-0692-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.2017
- Author(s)
  Han M, Zhang JC, Hashimoto K.
- Journal Title
  
  Clin Psychopharmacol Neurosci
  
  Volume: 15 Issue: 1 Pages: 64-67
- DOI
  10.9758/cpn.2017.15.1.64
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16F14711
[Journal Article] Intake of 7,8-Dihydroxyflavone During Juvenile and Adolescent Stages Prevents Onset of Psychosis in Adult Offspring After Maternal Immune Activation.2016
- Author(s)
  Han M, Zhang JC, Yao W, Yang C, Ishima T, Ren Q, Ma M, Dong C, Huang XF, Hashimoto K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 36087-36087
- DOI
  10.1038/srep36087
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16F14711
[Journal Article] Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.2016
- Author(s)
  Yoshimi N, Futamura T, Bergen SE, Iwayama Y, Ishima T, Sellgren C, Ekman CJ, Jakobsson J, Palsson E, Kakumoto K, Ohgi Y, Yoshikawa T, Landen M, Hashimoto K
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 21 Pages: 1504-1510
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24116001
[Journal Article] Ketamine's antidepressant action: beyond NMDA receptor inhibition.2016
- Author(s)
  Hashimoto K
- Journal Title
  
  Expert Opin Ther Targets
  
  Volume: 20 Issue: 11 Pages: 1389-1392
- DOI
  10.1080/14728222.2016.1238899
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression.2016
- Author(s)
  16.Liu WX, Wang J, Xu N, Xie ZM, Zhang GF, Jia M, Zhou ZQ, Hashimoto K, Yang, JJ.
- Journal Title
  
  Psychopharmacology
  
  Volume: 233 Issue: 3 Pages: 405-415
- DOI
  10.1007/s00213-015-4128-2
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Loss of parvalbumin-immunoreactivity in mouse brain regions after repeated intermittent administration of esketamine, but not R-ketamine.2016
- Author(s)
  Yang C, Han M, Zhang JC, Ren Q, Hashimoto K.
- Journal Title
  
  Psychiatry Res
  
  Volume: 239 Pages: 281-283
- DOI
  10.1016/j.psychres.2016.03.034
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-16J00514
[Journal Article] Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model.2016
- Author(s)
  13.Sun HL, Zhou ZQ, Zhang GF, Yang C, Wang XM, Shen JC, Hashimoto K, Yang JJ.
- Journal Title
  
  Translational Psychiatry
  
  Volume: 6 Issue: 2 Pages: e741-e741
- DOI
  10.1038/tp.2016.21
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: Evidence in support of mitochondrial dysfunction hypothesis.2016
- Author(s)
  11.Yoshimi N, Futamura T, Bergen SE, Iwayama Y, Ishima T, Sellgren C, Ekman CJ, Jakobsson J, Pålsson E, Kakumoto K, Ohgi Y, Yoshikawa T, Landén M, Hashimoto K
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 印刷中 Issue: 11 Pages: 1504-1510
- DOI
  10.1038/mp.2015.217
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15423, KAKENHI-PLANNED-24116002, KAKENHI-ORGANIZER-24116001
[Journal Article] Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression.2016
- Author(s)
  Yang B, Zhang JC, Han M, Yao W, Yang C, Ren Q, Ma M, Chen QX, Hashimoto K.
- Journal Title
  
  Psychopharmacology (Berl)
  
  Volume: 233 Issue: 19-20 Pages: 3647-3657
- DOI
  10.1007/s00213-016-4399-2
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.2016
- Author(s)
  Yoshimi N, Futamura T, Kakumoto K, Salehi AM, Sellgren CM, Holmén-Larsson J, Jakobsson J, Pålsson E, Landén M, Hashimoto K.
- Journal Title
  
  BBA Clinical
  
  Volume: 5 Pages: 151-158
- DOI
  10.1016/j.bbacli.2016.03.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15423
[Journal Article] Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia.2015
- Author(s)
  Balan S, Iwayama Y, Yamada K, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Ide M, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T, Maekawa M.
- Journal Title
  
  J Neural Transm
  
  Volume: 122 Issue: 3 Pages: 477-485
- DOI
  10.1007/s00702-014-1269-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293267, KAKENHI-PROJECT-26860954, KAKENHI-PROJECT-15K09849, KAKENHI-PLANNED-24116002, KAKENHI-ORGANIZER-24116001
[Journal Article] Antidepressant effects of TrkB ligands on depression-like behavior and dendtritic changes in the hippocampus and nucleus accumbens after inflammation.2015
- Author(s)
  Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K
- Journal Title
  
  Int. J. Neuropsychopharmacol.
  
  Volume: 18 Issue: 4 Pages: 1-5
- DOI
  10.1093/ijnp/pyu077
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] R-ketamine: a rapid-onset and sustained anmtidepressant without psychotomimetic side effects2015
- Author(s)
  9.Yang C, Shirayama Y, Zhang JC, Ren Q, Yao W, Ma M, Dong C, Hashimoto K.
- Journal Title
  
  Translational Psychiatry
  
  Volume: 5 Issue: 9 Pages: e632-e632
- DOI
  10.1038/tp.2015.136
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Population-dependent contribution of the major histocompatibility complex region to schizophrenia susceptibility.2015
- Author(s)
  Yamada K, Hattori E, Iwayama Y, Toyota T, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Mori N, Yoshikawa T
- Journal Title
  
  Schizophrenia Research
  
  Volume: 168 Issue: 1-2 Pages: 444-449
- DOI
  10.1016/j.schres.2015.08.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116002, KAKENHI-ORGANIZER-24116001
[Journal Article] Regional differences in brain-derived neurotrophic factor and dendritic spine density confer resilience to inescapable stress.2015
- Author(s)
  Yang C, Shirayama Y, Zhang JC, Ren Q, Hashimoto K
- Journal Title
  
  Int. J. Neuropsychopharmacol.
  
  Volume: in press Issue: 7
- DOI
  10.1093/ijnp/pyu121
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms.2015
- Author(s)
  8.Ren Q, Ma M, Yang C, Zhang JC, Yao W, Hashimoto K.
- Journal Title
  
  Translational Psychiatry
  
  Volume: 5 Issue: 10 Pages: e666-e666
- DOI
  10.1038/tp.2015.157
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-15J00058
[Journal Article] Genetic analysis of the glyoxalase system in schizophrenia.2015
- Author(s)
  Bangel FN, Yamada K, Arai M, Iwayama Y, Balan S, Toyota T, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Mori N, Itokawa M, Stork O, Yoshikawa T
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 59 Pages: 105-110
- DOI
  10.1016/j.pnpbp.2015.01.014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-25253074, KAKENHI-PROJECT-26293267, KAKENHI-PROJECT-26860954, KAKENHI-PROJECT-15K14973, KAKENHI-ORGANIZER-24116001
[Journal Article] Combination of nitrous oxide with isoflurane or scopolamine for treatment-resistant major depression.2015
- Author(s)
  Yang C, Hashimoto K
- Journal Title
  
  Clin. Psychopharmacol. Neurosci.
  
  Volume: 13（1） Issue: 1 Pages: 118-120
- DOI
  10.9758/cpn.2015.13.1.118
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders.2015
- Author(s)
  Ohgi Y, Futamura T, Hashimoto K.
- Journal Title
  
  Curr Mol Med
  
  Volume: 15 Pages: 206-221
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Effects of sodium benzoate on prepulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine.2015
- Author(s)
  Matsuura A, Fujita Y, Iyo M, Hashimoto K
- Journal Title
  
  Acta. Neuropsychiatr.
  
  Volume: in press Issue: 3 Pages: 159-167
- DOI
  10.1017/neu.2015.1
- NAID
  120007054170
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.2015
- Author(s)
  403.Zhang, J.C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., and Hashimoto, K.
- Journal Title
  
  Psychopharmacology
  
  Volume: 232 Issue: 23 Pages: 4325-4335
- DOI
  10.1007/s00213-015-4062-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19711, KAKENHI-PLANNED-24116006
[Journal Article] A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia2014
- Author(s)
  Niitsu T., Ishima T., Yoshida T., Hashimoto T., Matsuzawa D., Shirayama Y., Nakazato M., Shimizu E., Hashimoto K., and Iyo M
- Journal Title
  
  Psychiatry Res.
  
  Volume: 215 Issue: 2 Pages: 268-273
- DOI
  10.1016/j.psychres.2013.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Association study of H2AFZ with schizophrenia in a Japanese case-control sample.2014
- Author(s)
  Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T.
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 11 Issue: 6 Pages: 1-9
- DOI
  10.1007/s00702-014-1332-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791202, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-24390280, KAKENHI-ORGANIZER-24116001
[Journal Article] 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine2014
- Author(s)
  Ren Q., Zhang J.C., Ma M., Fujita Y., Wu J., Hashimoto K
- Journal Title
  
  Psychopharmacology
  
  Volume: 231 Issue: 1 Pages: 159-166
- DOI
  10.1007/s00213-013-3221-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Interaction of new antidepressants with sigma-1 receptor chaperones and their potentiation of neurite outgrowth in PC12 cells2014
- Author(s)
  Ishima T., Fujita Y., Hashimoto K
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 727 Pages: 167-173
- DOI
  10.1016/j.ejphar.2014.01.064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] R (-)-Ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine.2014
- Author(s)
  Ｚｈａｎｇ　ＪＣ　ｅｔ　ａｌ．
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 116 Pages: 137-143
- DOI
  10.1016/j.pbb.2013.11.033
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] A prospective comparative study of risperidone long-acting injectable for treatment-resistant schizophrenia with dopamine supersensitivity psychosis2014
- Author(s)
  Kimura H., Kanahara N., Komatsu N., Ishige M., Muneoka K., Yoshimura M., Yamanaka H., Suzuki T., Komatsu H., Sasaki T., Hashimoto T., Hasegawa T., Shiina A., Ishikawa M., Sekine Y., Shiraishi T., Watanabe H., Shimizu E., Hashimoto K., Iyo M
- Journal Title
  
  Schizophrenia Res.
  
  Volume: 155 Issue: 1-3 Pages: 52-58
- DOI
  10.1016/j.schres.2014.02.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Role of the NMDA receptor in cognitive deficits, anxiety, and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure.2014
- Author(s)
  Ｌｉ　ＳＸ　ｅｔ　ａｌ．
- Journal Title
  
  Ｎｅｕｒｏｂｉｏｌｏｇｙ　ｏｆ　Ｄｉｓｅａｓｅ
  
  Volume: 62 Pages: 124-134
- DOI
  10.1016/j.nbd.2013.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-αLevels and Depression-like Behavior in Mice after Lipopolysaccharide Administration2014
- Author(s)
  Ma M., Ren Q., Zhang J.C., Hashimoto K
- Journal Title
  
  Clin. Psychopharmacol. Neurosci.
  
  Volume: 12 Issue: 1 Pages: 31-36
- DOI
  10.9758/cpn.2014.12.1.31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] R-Stereoisomer of ketamine as alternative of ketamine for treatment-resistant major depression2014
- Author(s)
  Hashimoto K
- Journal Title
  
  Clin. Psychopharmacol. Neurosci.
  
  Volume: 12 Issue: 1 Pages: 72-73
- DOI
  10.9758/cpn.2014.12.1.72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Tipepidine in children with Attention-Deficit/Hyperactivity Disorder : A 4-week, open-label, preliminary study2014
- Author(s)
  Sasaki T., Hashimoto K., Tachibana M., Kurata T., Okawada K., Ishikawa M., Kimura H., Komatsu H., Ishikawa M., Hasegawa T., Shiina A., Hashimoto T., Kanahara N., Shiraishi T., Iyo M
- Journal Title
  
  preliminary study. Neuropsychiatrc. Dis. Treatment
  
  Volume: 10 Pages: 147-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Effects of antidepressants on alterations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration.2013
- Author(s)
  Ｏｈｇｉ　Ｙ．　ｅｔ　ａｌ
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 103 Issue: 4 Pages: 853-859
- DOI
  10.1016/j.pbb.2012.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] Old drug ifenprodil, new hope for PTSD with a history of childhood abuse.2013
- Author(s)
  Ｈａｓｈｉｍｏｔｏ　Ｋ．　ｅｔ　ａｌ
- Journal Title
  
  Ｐｓｙｃｈｏｐｈａｒｍａｃｏｌｏｇｙ
  
  Volume: 227 Issue: 2 Pages: 375-376
- DOI
  10.1007/s00213-013-3092-y
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] (2013) Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice.2013
- Author(s)
  Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 62 Pages: 843-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659557
[Journal Article] Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness2013
- Author(s)
  Muneoka K., Shirayama Y., Horio M., Iyo M., Hashimoto K
- Journal Title
  
  Psychopharmacology
  
  Volume: 229 Issue: 1 Pages: 63-71
- DOI
  10.1007/s00213-013-3080-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke2013
- Author(s)
  Marumo T, Takagi Y, Muraki K, Hashimoto N, Miyamoto S, Tanigaki K.
- Journal Title
  
  Neurosci Res
  
  Volume: 75(3) Issue: 3 Pages: 204-9
- DOI
  10.1016/j.neures.2013.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790350, KAKENHI-PROJECT-24659143, KAKENHI-PROJECT-25293308
[Journal Article] Effects of AS2586114, soluble epoxide hydrolase inhibitor, on hyperlocomotion and prepulse inhibition deficits in mice after administration of phencyclidine2013
- Author(s)
  Ma M., Ren Q., Fujita Y., Ishima T., Zhang J.C., Hashimoto K
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 110 Pages: 98-103
- DOI
  10.1016/j.pbb.2013.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Longitudinal changes in serum brain-derived neurotrophic factor in accidient survivors with posttraumatic stress disorder2013
- Author(s)
  Matsuoka Y., Nishi D., Noguchi H., Kim Y., Hashimoto K
- Journal Title
  
  Neuropsychobiology
  
  Volume: 68 Issue: 1 Pages: 44-50
- DOI
  10.1159/000350950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143, KAKENHI-PROJECT-25702043
[Journal Article] Neonatal disruption of serine racemase causes schizophrenia-like behavioral abnormalities in adulthood : Clinical rescue by D-serine2013
- Author(s)
  Hagiwara H., Iyo M., Hashimoto K
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62438-e62438
- DOI
  10.1371/journal.pone.0062438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Reply to : Acute stress symptoms do not worsen in PTSD and abuse with a single subanesthetic dose of ketamine2013
- Author(s)
  Kishimoto A., Hashimoto K
- Journal Title
  
  Biol. Psychiatry
  
  Volume: 73 Issue: 12 Pages: e39-e39
- DOI
  10.1016/j.biopsych.2012.10.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice2013
- Author(s)
  Horio M., Fujita Y., Hashimoto K
- Journal Title
  
  Fund. Clin. Pharmacol.
  
  Volume: 27 Issue: 5 Pages: 483-488
- DOI
  10.1111/j.1472-8206.2012.01045.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Potential role of sigma-1 receptor chaperone in the beneficial effects of donepezil for dementia with Lewy bodies2013
- Author(s)
  Hashimoto K
- Journal Title
  
  Clin. Psychopharmacol. Neurosci.
  
  Volume: 11 Issue: 1 Pages: 43-44
- DOI
  10.9758/cpn.2013.11.1.43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Prenatal immune activation and subsequent peripubertal stress as a new model of schizophrenia2013
- Author(s)
  Yoshimi N., Futamura T., Hashimoto K
- Journal Title
  
  Expert Rev. Neurother.
  
  Volume: 13 Issue: 7 Pages: 747-750
- DOI
  10.1586/14737175.2013.811191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Long-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of mice.2013
- Author(s)
  Ｍａ　ＸＣ　ｅｔ　ａｌ
- Journal Title
  
  ＰＬＯＳ　ＯＮＥ
  
  Volume: 8 Issue: 2 Pages: e56053-e56053
- DOI
  10.1371/journal.pone.0056053
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine, but not quetiapine2013
- Author(s)
  Ünsal C., Albayrak Y., Albayrak N., Kuloğlu M., Hashimoto K
- Journal Title
  
  Neuropsychiatrc Dis. Treatment
  
  Volume: 9 Pages: 1545-1552
- DOI
  10.2147/ndt.s52463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Ifenprodil for the treatment of flashbacks in adolescent female posttraumatic stress disorder patients with a history of abuse2013
- Author(s)
  Sasaki T., Hashimoto K., Okawada K., Tone J., Machizawa A., Tano A., Nakazato M., Iyo M
- Journal Title
  
  Psychother. Psychosom.
  
  Volume: 82 Issue: 5 Pages: 344-345
- DOI
  10.1159/000348585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice2013
- Author(s)
  Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K
- Journal Title
  
  Neurochem. Int
  
  Volume: 62 Issue: 6 Pages: 843-847
- DOI
  10.1016/j.neuint.2013.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220, KAKENHI-PROJECT-23659557, KAKENHI-PROJECT-24659143
[Journal Article] Is D-cycloserine a prodrug forD-serine in the brain? Biol2013
- Author(s)
  Horio, M., Mori, H., and Hashimoto, K
- Journal Title
  
  Psychiatry
  
  Volume: (in press) Issue: 12 Pages: e33-e34
- DOI
  10.1016/j.biopsych.2012.07.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220, KAKENHI-PROJECT-23659557, KAKENHI-PROJECT-24659143
[Journal Article] Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders2013
- Author(s)
  Hashimoto, K., Malchow, B., Falkai, P., and Schmitt, A
- Journal Title
  
  Eur. Arch. Psychiatry Clin. Neurosci
  
  Volume: (in press) Issue: 5 Pages: 367-377
- DOI
  10.1007/s00406-013-0399-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220, KAKENHI-PLANNED-24116006, KAKENHI-PROJECT-24659143
[Journal Article] Beneficial effects of sigma-1 agonist fluvoxamine for tardive dyskinesia and tardive akathisia in patients with schizophrenia : report of three cases2013
- Author(s)
  Albayrak Y., Hashimoto K
- Journal Title
  
  Psychiatry Investigation
  
  Volume: 10 Issue: 4 Pages: 417-420
- DOI
  10.4306/pi.2013.10.4.417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine2013
- Author(s)
  Ren Q., Zhang J.C., Fujita Y., Ma M., Wu J., Hashimoto K
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 106 Pages: 124-127
- DOI
  10.1016/j.pbb.2013.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Neonatal disruption of serine racemase causes schizophrenia-like behavioral abnormalities in adulthood: Clinical rescue by D-serine2013
- Author(s)
  Hagiwara, H., Iyo, M., and Hashimoto, K
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220
[Journal Article] Optimal extent of dopamine D_2 receptor occupancy by antipsychotics for treatment of dopamine supersensitivity psychosis and late-onset psychosis2013
- Author(s)
  Iyo M., Tadokoro S., Kanahara N., Niitsu T., Watanabe H., Hashimoto K
- Journal Title
  
  J. Clin. Psychopharmacol.
  
  Volume: 33 Issue: 3 Pages: 398-404
- DOI
  10.1097/jcp.0b013e31828ea95c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Sigma-1 receptor chaperone and brain-derived neurotrophic factor : emerging links between cardiovascular disease and depression2013
- Author(s)
  Hashimoto K
- Journal Title
  
  Prog. Neurobiol.
  
  Volume: 100 Pages: 15-29
- DOI
  10.1016/j.pneurobio.2012.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143, KAKENHI-PLANNED-24116006
[Journal Article] Understanding depression: linking brain-derived neurotrophic factor (BDNF), transglutaminase 2 (TG2), and serotonin2013
- Author(s)
  Hashimoto K
- Journal Title
  
  Expert Review of Neurotherapeutics
  
  Volume: 13 Issue: 1 Pages: 5-7
- DOI
  10.1586/ern.12.140
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116006
[Journal Article] Effects of the antioxidant sulforaphane on hyperlocomotion and prepulse inhibition deficits in mice after administration of phencyclidine2012
- Author(s)
  Shirai Y., Fujita Y., Hashimoto K
- Journal Title
  
  Clin. Psychopharmacol. Neurosci.
  
  Volume: 10 Issue: 2 Pages: 94-98
- DOI
  10.9758/cpn.2012.10.2.94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] In Vivo Evaluation of (11)C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse Brain2012
- Author(s)
  Zhang J.C., Toyohara J., Wu J., Ishiwata K., Hashimoto, K
- Journal Title
  
  Clin Psychopharmacol Neurosci.
  
  Volume: 10 Issue: 1 Pages: 34-43
- DOI
  10.9758/cpn.2012.10.1.34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine2012
- Author(s)
  Horio M., Kohno M., Fujita Y., Ishima T, Inoue R, Mori H, Hashimoto K
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Protective effects of antioxidant sulforaphane on the behavioral changes and neurotoxicity in mice after administration of methamphetamine2012
- Author(s)
  Chen H., Wu J., Zhang J., Fujita Y., Ishima T., Iyo M., Hashimoto K
- Journal Title
  
  Psychopharmacology
  
  Volume: 222 Issue: 1 Pages: 37-45
- DOI
  10.1007/s00213-011-2619-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.2012
- Author(s)
  Tamaki Ishima
- Journal Title
  
  PLoS One.
  
  Volume: 7(5) Issue: 5 Pages: e37989-e37989
- DOI
  10.1371/journal.pone.0037989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791308, KAKENHI-PROJECT-24659143
[Journal Article] Depressive-like behavior in adrenocorticotropic hormone-treated rats by blocked by memantine2012
- Author(s)
  Tokita K., Fujita Y., Yamaji T., Hashimoto K
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 102 Issue: 2 Pages: 329-334
- DOI
  10.1016/j.pbb.2012.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Beneficial effects of sigma-1 agonist fluvoxamine for tardive dyskinesia in patients with post-psychotic depression : report of five cases2012
- Author(s)
  Albayrak Y., Hashimoto K
- Journal Title
  
  Prim. Care Companion CNS Disorders
  
  Volume: 14
- DOI
  10.4088/pcc.12br01401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.2012
- Author(s)
  Tamaki Ishima
- Journal Title
  
  Translational Psychiatry
  
  Volume: 2 Issue: 10 Pages: e170-e170
- DOI
  10.1038/tp.2012.97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791308, KAKENHI-PROJECT-24659143
[Journal Article] Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine2012
- Author(s)
  Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 4 Pages: e35494-e35494
- DOI
  10.1371/journal.pone.0035494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220
[Journal Article] Possible involvement of brain-derived neurotrophic factor (BDNF) in eating disorders2012
- Author(s)
  Nakazato M., Hashimoto K., Shimizu E., Niitsu T., Iyo M
- Journal Title
  
  IUBMB Life
  
  Volume: 64 Issue: 5 Pages: 355-361
- DOI
  10.1002/iub.1012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] (2013) Is D-cycloserine a prodrug forD-serine in the brain? Biol.2012
- Author(s)
  Horio, M., Mori, H., and Hashimoto, K.
- Journal Title
  
  Psychiatry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659557
[Journal Article] The antibiotic minocycline prevents methamphetamine-induced rewarding effects in mice2012
- Author(s)
  Fujita Y., Kunitachi S., Iyo M., Hashimoto K
- Journal Title
  
  Pharmacol. Biochem. Behav.
  
  Volume: 101 Issue: 2 Pages: 303-306
- DOI
  10.1016/j.pbb.2012.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder2012
- Author(s)
  Yoshida T., Ishikawa M., Niitsu T., Nakazato M., Watanabe H., Shiraishi T., Shiina A., Hashimoto T., Kanahara N., Hasegawa T., Enohara M., Kimura H., Iyo M., Hashimoto K
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 8 Pages: e42676-e42676
- DOI
  10.1371/journal.pone.0042676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia : a preliminary study2012
- Author(s)
  Niitsu T., Fujisaki M., Shiina A., Yoshida T., Hasegawa T., Kanahara N., Hashimoto T., Shiraishi T., Fukami G., Nakazato M., Shirayama Y., Hashimoto K., Iyo M
- Journal Title
  
  J. Clin. Psychopharmacol.
  
  Volume: 32 Issue: 1 Pages: 593-601
- DOI
  10.1186/1744-859x-9-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659143
[Journal Article] Magnetic resonance spectroscopy study of the antioxidant defense system in schizophrenia2011
- Author(s)
  Matsuzawa D, Hashimoto K
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: 15 Issue: 7 Pages: 2057-2065
- DOI
  10.1089/ars.2010.3453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220
[Journal Article] (2011) Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice.2011
- Author(s)
  Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 59 Pages: 853-859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659557
[Journal Article] Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice2011
- Author(s)
  Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
- Journal Title
  
  Neurochem. Int
  
  Volume: 59 Issue: 6 Pages: 853-859
- DOI
  10.1016/j.neuint.2011.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220
[Journal Article] Chronic Treatment With Aripiprazole Prevents Development of Dopamine Supersensitivity and Potentially Supersensitivity Psychosis2011
- Author(s)
  Tadokoro S, et al.
- Journal Title
  
  Schizophr Bull
  
  Volume: 38 Issue: 5 Pages: 1-9
- DOI
  10.1093/schbul/sbr006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390110, KAKENHI-PROJECT-24659143
[Journal Article] Glycine transport inhibitors for the treatment of schizophrenia.2010
- Author(s)
  Hashimoto K
- Journal Title
  
  The Open Medicinal Chemistry Journal (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Comments to"The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia"2010
- Author(s)
  K.Hashimoto
- Journal Title
  
  J.Psychopharmacol.
  
  Volume: 24 Pages: 1133-1134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390220
[Journal Article] Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-8012010
- Author(s)
  Okamura, N., Reinscheid, R., Ohgake, S., Iyo, M., Hashimoto, K.
- Journal Title
  
  Neuropharmacology 58
  
  Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Comments to "The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia"2010
- Author(s)
  Hashimoto K
- Journal Title
  
  Journal of Psychopharmacology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Co-administration of D-amino acid oxidase inhibitor potentiates the efficacy of D-serine on prepulse inhibition deficits after administration of dizocilpine2009
- Author(s)
  Hashimoto, K., Fujita, Y., Horio, M., Kunitachi, S., Iyo, M., Ferraris, D., Tsukamoto, T.
- Journal Title
  
  Biol.Psychiatry 65
  
  Pages: 1103-1106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Co-administration of D-amino acid oxidase inhibitor potentiates the efficacy of D-serine on prepulse inhibition deficits after administration of dizocilpine.2009
- Author(s)
  Hashimoto K et al.
- Journal Title
  
  Biological Psychiatry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of donepezil : role of sigma-1 receptors2009
- Author(s)
  Kunitachi, S., Fujita, Y., Ishima, T., Kohno, M., Horio, M., Tanibuchi, Y., Shirayama, Y., Iyo, M., Hashimoto, K.
- Journal Title
  
  Brain Res. 1279
  
  Pages: 189-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Co-administration of D-amino acid oxidase inhibitor potentiates the efficacy of D-serine on prepulse inhibition deficits after administration of dizocilpine.2009
- Author(s)
  Hashimoto K, et al.
- Journal Title
  
  Biological Psychiatry 65
  
  Pages: 1103-1106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Effects of D-amino acid oxidase inhibitor on the extracellular D-alanine levels and the efficacy of D-alanine on dizocilpine-induced prepulse inhibition deficits in mice2009
- Author(s)
  Horio, M., Fujita, Y., Ishima, T., Iyo, M., Ferraris, D., Tsukamoto, T., Hashimoto, K.
- Journal Title
  
  Open Clin.Chem.J. 2
  
  Pages: 16-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of glycine transporter-1 inhibitor NFPS and D-serine2008
- Author(s)
  Hashimoto, K., Fujita, Y., Ishima, T., Chaki, S., Iyo, M.
- Journal Title
  
  Eur.Neuropsychopharmacol. 18
  
  Pages: 414-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of glycine transporter-1 inhibitor NFPS and D-serine2008
- Author(s)
  Hashimoto K., et. al.
- Journal Title
  
  European Neuropsychopharmacology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] D-serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats2008
- Author(s)
  Karasawa, J., Hashimoto, K., Chaki, S.
- Journal Title
  
  Behav.Brain Res. 186
  
  Pages: 78-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone : role of serotonin 5-HT_<1A> receptor2008
- Author(s)
  Hagiwara, H., Fujita, Y., Ishima, T., Kunitachi, S., Shirayama, Y., Iyo, M., Hashimoto, K.
- Journal Title
  
  Eur.Neuropsychopharmacol. 18
  
  Pages: 448-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Deficits in auditory P50 inhibition in obsessive-compulsive disorder2008
- Author(s)
  Hashimoto T, Shimizu E, et. al.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry 32(1)
  
  Pages: 288-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of glycine transporter-1 inhibitor NFPS and D-serine.2008
- Author(s)
  Hashimoto K et al.
- Journal Title
  
  European Neuropsychopharmacology 18(6)
  
  Pages: 414-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective α7 nicotinic receptor agonist SSR1807112008
- Author(s)
  Hashimoto, K., Ishima, T., Fujita, Y., Matsuo, M., Kobashi, T., Takahagi, M., Tsukada, H., Iyo, M.
- Journal Title
  
  Biol.Psychiatry 63
  
  Pages: 92-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] et.al.Deficits in auditory P50 inhibition inobsessive-compulsive disorder2008
- Author(s)
  Hashimoto T, Shimizu E, et.al.
- Journal Title
  
  Prog Neuropsychopharmacol BiolPsychiatry 321)
  
  Pages: 288-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Food addictives and hyperactive behaviors in children2008
- Author(s)
  Hashimoto, K.
- Journal Title
  
  Clin.Psychopharmacol.Neurosci. 6
  
  Pages: 79-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Glycine and D-serine, but not D-cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-8012008
- Author(s)
  Kanahara, N., Shimizu, E., Ohgake, S., Fujita, Y., Kohno, M., Hashimoto, T., Matsuzawa, D., Shirayama, Y., Hashimoto, K., Iyo, M.
- Journal Title
  
  Psychopharmacology 198
  
  Pages: 363-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Modulation of D-serine levels in brains of mice lacking PICK12008
- Author(s)
  Hikida, T., Mustafa, A. K., Maeda, K., Fujii, K., Barrow, R. K., Saleh, M., Oby, L., Huganir, R. L., Snyder, S. H., Hashimoto, K., Sawa, A.
- Journal Title
  
  Biol.Psychiatry 63
  
  Pages: 997-1000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] NMDA-and β-amyloid_<1-42>-induced neurotoxicity is attenuated in serine racemase knockout mice2008
- Author(s)
  Inoue, R., Hashimoto, K., Harai, T., Mori, H.
- Journal Title
  
  J.Neurosci. 28
  
  Pages: 14486-14491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-Induced Cognitive Deficits in Mice are Improved by Subsequent Subchronic Administration of Fluvoxamine : Role of Sigma-1 Receptors.2007
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Neuropsychopharamacology 32・3
  
  Pages: 514-521
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Glycine transporter-1 inhibitors as novel therapeutic drugs for schizophrenia2007
- Author(s)
  Hashimoto, K.
- Journal Title
  
  CNS Agents Med.Chem. 7
  
  Pages: 177-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390301
[Journal Article] Phencyclidine-Induced Cognitive Deficits in Mice are Improved by Subsequent Subchronic Administration of Fluvoxamine : Role of Sigma-1 Receptors.2007
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Neuropsychopharmacology 32・3
  
  Pages: 514-521
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] et.al.Identification of functionalpolymorphisms in the promoter region ofthe human PICK1 gene and their associationwith methamphetamine psychosis2007
- Author(s)
  Matsuzawa D, Hashimoto K, Miyatake R,Shirayama Y, Shimizu E, et.al.
- Journal Title
  
  Am J Psychiatry 1647)
  
  Pages: 1105-1114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Posterior cingulategyrus metabolic changes in chronicschizophrenia with generalized cognitivedeficits2007
- Author(s)
  Shimizu E, Hashimoto K, Ochi S, FukamiG, Fujisaki M, et.al.
- Journal Title
  
  J Psychiatr Res 411-2)
  
  Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Glycine transporter-1 inhibitors as novel therapeutic drugs for schizophrenia.2007
- Author(s)
  Hashimoto K.
- Journal Title
  
  CNS Agents Med. Chem. 7
  
  Pages: 177-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18053004
[Journal Article] Phencyclidine-Induced Cognitive Deficits in Mice are Improved by Subsequent Subchronic Administration of Fluvoxamine : Role of Sigma-1 Receptors.2007
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  32(3)
  
  Pages: 514-521
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Increased levels of glutamate in brains from patients with mood disorders.2007
- Author(s)
  Hashimoto K, et. al.
- Journal Title
  
  Biol. Psychiatry 62
  
  Pages: 1310-1316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18053004
[Journal Article] Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits.2007
- Author(s)
  Shimizu E, Hashimoto K, Ochi S, Fukami G, Fujisaki M, et al.
- Journal Title
  
  J Psychiatr Res 41(1-2)
  
  Pages: 49-56
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with menthamphtamine psychosis2007
- Author(s)
  Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, et. al.
- Journal Title
  
  Am J psychiatry 164(7)
  
  Pages: 1105-1114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder2007
- Author(s)
  Okamura N, Hashimoto K, Iyo M, S himizu E, et. al.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry 31(7)
  
  Pages: 1444-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] et.al. Gender-specificassociation of a functional codingpolymorphism in the Neuropeptide Sreceptor gene with panic disorder but notwith schizophrenia orattention-deficit/hyperactivitydisorder.2007
- Author(s)
  Okamura N, Hashimoto K, Iyo M, ShimizuE, et.al.
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry 317)
  
  Pages: 1444-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Possible applications as therapeutic drugs and as radiopharmaceuticals.2006
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Curr Pharm Des 12(30)
  
  Pages: 3857-3876
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Protective effects of minocycline on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain.2006
- Author(s)
  Zhang L, Shirayama Y, Shimizu E, Iyo M, Hashimoto K.
- Journal Title
  
  Eur J Pharmacol 544(1-3)
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] The NMDA receptor hypofunction gypothesis for schizophrenia and glycine modulatory sites on the NMDA receptors as potential therapeutic drugs.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  Clin Psychopharmacol Neurosci 4・1
  
  Pages: 3-10
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron : Role of α7 nicotinic receptors.2006
- Author(s)
  Hashimoto K et al.
- Journal Title
  
  Eur J Pharmacol 28・553(1-3)
  
  Pages: 191-195
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Sigma receptor ligands : Possible applications as therapeutic drugs and as radiopharmaceuticals.2006
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Curr Pharm Des 12・30
  
  Pages: 3857-3876
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Glycine transporter inhibitors as therapeutic agents for schizophrenia.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  Recent Patents on CNS Drug Discovery 1・
  
  Pages: 43-53
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Glycine transporter inhibitors as therapeutic agents for schizophrenia.2006
- Author(s)
  Hashimoto K
- Journal Title
  
  Recent Patents on CNS Drug Discovery 1
  
  Pages: 43-53
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron : Role of α7 nicotinic receptors.2006
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  553(1-3)
  
  Pages: 191-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] The NMDA receptor hypofunction hypothesis for schizophrenia and glycine modulatory sites on the NMDA receptors as potential therapeutic drugs.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  Clin Psychopharmacol Neurosci 4・(1)
  
  Pages: 3-10
- Data Source
  KAKENHI-PROJECT-18053004
[Journal Article] The NMDA receptor hypofunction hypothesis for schizophrenia and glycine modulatory sites on the NMDA receptors as potential therapeutic drugs.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  4(1)
  
  Pages: 3-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] The NMDA receptor hypofunction hypothesis for schizophrenia and glycine modulatory sites on the NMDA receptors as potential therapeutic drugs.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  Clin Psychopharmacol Neurosci 4・1
  
  Pages: 3-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Glycine transporter inhibitors as therapeutic agents for schizophrenia.2006
- Author(s)
  Hashimoto K.
- Journal Title
  
  Recent Patients on CNS Drug Discovery 1
  
  Pages: 43-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Protective effects ofminocycline on3, 4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic anddopaminergic neurons of mouse brain2006
- Author(s)
  Zhang L, Shirayama Y, Shimizu E, IYO M, Hashimoto K
- Journal Title
  
  Eur J Pharmacol 5441-3)
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500289
[Journal Article] Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron : Role of α7 nicotinic receptors.2006
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Eur J Pharmacol 28・553(1-3)
  
  Pages: 191-195
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Dysfunction of glia-neuron communication in pathophysiology of schizopherenia.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Current Psychiatry Review 1・2
  
  Pages: 151-163
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K et al.
- Journal Title
  
  BMC Psychiatry 5・1
  
  Pages: 6-6
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] α7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Current Medicinal Chemistry CNS Agents 5・3
  
  Pages: 171-184
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Progress in Neuro-Psychopharmacology & Biological Psychiatry 29・5
  
  Pages: 767-769
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Progress in Neuro-Psychopharmacology & Biological Psychiatry 29・5
  
  Pages: 767-769
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  BMC Psychiatry 5・1
  
  Pages: 6-6
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Identification of multiple serine recemase mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Biological Psychiatry (In press)
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry (In press)
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Dysfunction of glia-neuron communication in pathophysiology of schizophrenia.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Current Psychiatry Review 1・2
  
  Pages: 151-163
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients.2005
- Author(s)
  Hashimoto K et al.
- Journal Title
  
  BMC Psychiatry 5・1
  
  Pages: 6-6
- Data Source
  KAKENHI-PROJECT-17390316
[Journal Article] α7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia.2005
- Author(s)
  Hashimoto K. et al.
- Journal Title
  
  Current Medicinal Chemistry CNS Agents 5・3
  
  Pages: 171-184
- Data Source
  KAKENHI-PROJECT-16047203
[Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
- Author(s)
  Takizawa R, Hashimoto K, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390319
[Patent] 薬物依存症の治療薬としてのTrkB受容体拮抗薬2014
- Inventor(s)
  橋本謙二
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-230008
- Filing Date
  2014-11-12
- Data Source
  KAKENHI-PLANNED-24116006
[Patent] R-ケタミンおよびその塩の医薬品としての応用2014
- Inventor(s)
  橋本謙二
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-190066
- Filing Date
  2014-09-12
- Overseas
- Data Source
  KAKENHI-PLANNED-24116006
[Patent] R-ケタミンおよびその塩の医薬品としての応用．2013
- Inventor(s)
  橋本謙二
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-190066
- Filing Date
  2013-09-13
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] Recent topics on antidepressant effects of ketamine enantiomers2021
- Author(s)
  Kenji Hashimoto
- Organizer
  Zhongyuan-International Neuroscience and Anesthesiology Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Presentation] Prophylactic effects of (R)-ketamine on schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling2021
- Author(s)
  Kenji Hashimoto
- Organizer
  American College of Neuropsychopharmacology (ACNP)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02846
[Presentation] Sulforaphane: A prophylactic natural compound for psychiatric disorders.2018
- Author(s)
  Kenji Hashimoto
- Organizer
  The 8th Mind-Body Interface International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04243
[Presentation] Sulforaphane as prophylactic compound for the onset of depression and psychosis2017
- Author(s)
  Kenji Hashimoto
- Organizer
  ISNPR2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04243
[Presentation] Supplementation of 7,8-dihydroxyflavone during juvenile and adolescence prevents onset of schizophrenia-like symptoms at adulthood of offspring after maternal immune activation2016
- Author(s)
  Han M, Zhang JC, Yao W, Yang C, REn Q, Ma M, Dong C, Hashimoto K
- Organizer
  第39回日本神経科学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16F14711
[Presentation] 双極性障害患者の血液メタボロミクス解析によるクエン酸回路、尿素回路、アミノ酸代謝の異常2016
- Author(s)
  275.吉見典子、二村隆史、角元慶二、サレヒ　アリレザ、セルグレン　カール、ホルメンーラーション　ジェシカ、ジャコブソン　ジョエル、ポルソン　エリック、ランデン　ミカエル、橋本謙二
- Organizer
  第46回日本神経精神薬理学会
- Place of Presentation
  韓国ソウル市
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-15K15423
[Presentation] Metabolomic analysis of CSF from patients with bipolar disorder2016
- Author(s)
  Hashimoto K
- Organizer
  16th Conference of the International Society for Monitoring Molecules in Neuroscience
- Place of Presentation
  スウェーデン国エーテボリ市
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15423
[Presentation] 脳脊髄液のメタボロミクス解析による双極性障害におけるイソクエン酸デヒドロゲナーゼの異常2016
- Author(s)
  278.吉見典子、二村隆史、ベルゲン　サラ、岩山佳美、セルグレン　カール、エクマン　カール、ジャコブソン　ジョエル、ポルソン　エリック、石間　環、角元慶二、大木雄太、菊池哲郎、吉川武男、ランデン　ミカエル、橋本謙二
- Organizer
  第46回日本神経精神薬理学会
- Place of Presentation
  韓国ソウル市
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-15K15423
[Presentation] うつ病治療におけるBDNF-TrkB-mTORシグナルの役割2015
- Author(s)
  橋本謙二
- Organizer
  第45回日本神経精神薬理学会/第37回日本生物学的精神医学会合同学会
- Place of Presentation
  タワーホール船堀（東京都・江戸川区）
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] BDNF-TrkB signaling as a potential therapeutic target for methamphetamine abuse.2015
- Author(s)
  Kenji Hashimoto
- Organizer
  ＷＰＡ　Ｃｏｎｇｒｅｓｓ
- Place of Presentation
  Ｔａｉｐｅｉ，　Ｔａｉｗａｎ
- Year and Date
  2015-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] 即効性の抗うつ薬および気分安定薬の可能性2015
- Author(s)
  橋本謙二
- Organizer
  第12回日本うつ病学会総会/第15回日本認知療法学会同時開催
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] Auditory sensory gating and inflammation as translational biomarkers of alpha-7 nicotinic acetylcholine receptor agonists in the treatment of neuropsychiatric disorders2015
- Author(s)
  Kenji Hashimoto
- Organizer
  Satellite Events of Society for Neuroscience Meeting
- Place of Presentation
  Ｃｈｉｃａｇｏ，　ＩＬ，　ＵＳＡ
- Year and Date
  2015-10-14
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] トランスレーショナル・バイオマーカーを用いた統合失調症の新規治療薬の開発．2014
- Author(s)
  橋本謙二
- Organizer
  第9回統合失調症学会
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-25670510
[Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012
- Author(s)
  堀尾菜央、森寿、橋本謙二
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀県大津市
- Data Source
  KAKENHI-PROJECT-22390220
[Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012
- Author(s)
  堀尾菜央、森寿、橋本謙二
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀県大津市
- Data Source
  KAKENHI-PROJECT-23659557
[Presentation] D－サイクロセリンは、脳においてD-セリンのプロドラッグか？2012
- Author(s)
  堀尾菜央（橋本謙二）
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀県大津市
- Data Source
  KAKENHI-PROJECT-23659557
[Presentation] D－サイクロセリンは、脳においてD-セリンのプロドラッグか？2012
- Author(s)
  堀尾菜央（橋本謙二）
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀県大津市
- Invited
- Data Source
  KAKENHI-PROJECT-22390220
[Presentation] Therapeutic effects of metabotropic glutamate receptor 5positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice2012
- Author(s)
  Hashimoto, K., Horio, M., and Fujita, Y
- Organizer
  22^<nd> Neuropharmacology Conference "Cognitive Enhancers"
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22390220
[Presentation] セリンラセマーゼ遺伝子欠損マウスでの覚せい剤投与による行動感作の欠如2011
- Author(s)
  堀尾菜央、河野眞美、藤田有子、井上蘭、森寿、橋本謙二
- Organizer
  第7回D-アミノ酸研究会学術講演会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-22390220
[Presentation] セリンラセマーゼ遺伝子欠損マウスでの覚せい剤投与による行動感作の欠如2011
- Author(s)
  堀尾菜央、河野眞美、藤田有子、井上蘭、森寿、橋本謙二
- Organizer
  第7回D-アミノ酸研究会学術講演会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23659557
[Presentation] Lack of behavioral sensitization in serine racemase knock-out mice after administration of methamphetamine2011
- Author(s)
  Horio, M., Fujita, Y., Kohno, M., Inoue, R., Mori, H., and Hashimoto, K
- Organizer
  The 41th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22390220
[Presentation] Reduction of D-serine in neonatal mouse brain caused schizophrenia-like behavioral abnormalities in adulthood ; a novel animal model of schizophrenia2009
- Author(s)
  Hagiwara, H., Iyo, M., Hashimoto K.
- Organizer
  World Psychiatric Association-International Congress
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] 脳内D-セリンの機能解析2008
- Author(s)
  趙英らん, 宮一志, 橋本謙二, 森寿
- Organizer
  第31回日本神経科学会大会
- Place of Presentation
  東京都
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] 古典的恐怖条件づけの獲得および消去過程における聴性誘発電位P50 抑制の変化第38 回日本臨床神経生理学会学術大会2008
- Author(s)
  倉山太一、中澤健、松澤大輔、橋本佐、南部誠、吉田晋、伊豫雅臣、清水栄司
- Organizer
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-18500289
[Presentation] プレパルスインヒビションのQTL解析による責任遺伝子の同定2008
- Author(s)
  Watanabe, A., Toyota, T., Owada, Y., Hayashi, T., Iwayama, Y., Matsumata, M., Ishitsuka, Y., Maekawa, M., Ohnishi, T., Yamada, K., Hashimoto, K., Osumi, N., Yoshikawa, T.
- Organizer
  第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同学会
- Place of Presentation
  東京都
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] フェインサイクリジン投与による認知機能障害に及ぼす非定型抗精神病薬ペロスピロンの効果2008
- Author(s)
  萩原裕子, 藤田有子, 石間環, 伊豫雅臣, 橋本謙二
- Organizer
  第13回日本行動薬理研究会
- Place of Presentation
  千葉市
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] [^<11>C]CHIBA-1001 as a novel PET ligand for α7 nicotinic receptors in the brain2008
- Author(s)
  Hashimoto, K., Nishiyama, S., Ohba, H., Matsuo, M., Kobashi, T., Takahagi, M., Iyo, M., Kitashoji, T., Tsukada, H.
- Organizer
  The 38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Co-administration of D-amino acid oxidase inhibitor potentiates the efficacy of D-serine on dizocilpine-induced cognitive deficits2008
- Author(s)
  Fujita, Y., Ishima, T., Horio, M., Matsuzawa, D., Iyo, M., Ferraris, D., Tsukamoto, T., Hashimoto, K.
- Organizer
  The 38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Phencyclidine-induced cognitive deficits are ameliorated by subsequent subchronic administration of donepezil : role of sigma-1 receptors2008
- Author(s)
  Kunitachi, S., Fujita, Y., Ishima, T., Kohno, M., Hagiwara, H., Shirayama, Y., Iyo, M., Hashimoto, K.
- Organizer
  The 38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] MK-801によるプレパルス抑制障害に対するNMDA受容体グリシンサイトアゴニストの改善作用2008
- Author(s)
  金原信久, 清水栄司, 大掛真太郎, 藤田有子, 橋本謙二, 伊豫雅臣
- Organizer
  第13回日本行動薬理研究会
- Place of Presentation
  千葉市
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] 3D-SSP-SPECT による統合失調症患者の脳血流変化~病初期群、亜慢性群、慢性群における比較検討~2007
- Author(s)
  清水栄司、金原信久、内田佳孝、橋本佐、原口正、松澤大輔、宮武良輔、藤崎美久、白山幸彦、浅野誠、橋本謙二、伊豫雅臣
- Organizer
  第2 回日本統合失調症学会富山国際会議場
- Place of Presentation
  富山
- Year and Date
  2007-03-24
- Data Source
  KAKENHI-PROJECT-18500289
[Presentation] Glycine improves MK-801 induced prepulseinhibition deficits in a way similar toD-serine2007
- Author(s)
  Nobuhisa Kanahara, Eiji Shimizu, Shintaro Ohgake, Kenji Hashimoto, YukoFujita,Tasuku Hashimoto, YukihikoShirayama, Masaomi Iyo
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会・合同年会札幌
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-18500289
[Presentation] フェインサイクリジン投与による認知機能障害に及ぼすα7ニコチン受容体アゴニストSSR 180711の効果2007
- Author(s)
  石間環, 藤田有子, 松尾昌昭, 小橋達弘, 高萩誠, 塚田秀夫, 伊豫雅臣, 橋本謙二
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Glycine improves MK-801 induced prepulse inhibition deficits in a way similar to D-serine2007
- Author(s)
  Kanahara, N., Shimizu, E., Ohgake, S., Hashimoto, K., Fujita, Y., Hashimoto, T., Shirayama, Y., Iyo, M.
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Synthesis of D-amino acid oxidase inhibitors and their effect on the plasma and brain levels of D-serine2007
- Author(s)
  Duvall, B., Ferraris, D., Ko, Y. S., Thomas, A., Rojas, C., Tsukamoto, T., Hashimoto, K.
- Organizer
  234^<th> ACS National Meeting & Exposition
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] フェインサイクリジン投与による認知機能障害に及ぼすグリシントランスポーター1阻害薬NFPSの効果2007
- Author(s)
  藤田有子, 石間環, 茶木茂之, 伊豫雅臣, 橋本謙二
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Phencyclidine-induced cognitive deficits are ameliorated by subsequent subchronic administration of the selective α7 nicotinic receptor agonist SSR1807112007
- Author(s)
  Hashimoto, K., Ishima, T., Fujita, Y., Matsuo, M., Kobashi, T., Takahagi, M., Tsukada, H., Iyo, M.
- Organizer
  The 37th Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] フェインサイクリジン投与による認知機能障害に及ぼす非定型抗精神病薬ペロスピロンの効果2007
- Author(s)
  萩原裕子, 藤田有子, 石間環, 伊豫雅臣, 橋本謙二
- Organizer
  第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] セリンラセマーゼノックアウトを用いた脳内D-セリンの機能解析2007
- Author(s)
  趙英らん, 高田義美, 橋本謙二, 崎村健司, 森寿
- Organizer
  第30回日本神経科学大会・第50回日本神経化学大会・第17回日本神経回路学会大会合同学会
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Phencyclidine-induced cognitive deficits are ameliorated by subsequent subchronic administration of glycine transporter-1 inhibitor and D-serine2006
- Author(s)
  Hashimoto, K., Fujita, Y., Ishima, T., Chaki, S., Iyo, M.
- Organizer
  The 36th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Genetic architecture that defines prepulse inhibition in mice and relevance of candidate genes to schizophrenia2006
- Author(s)
  Watanabe, A., Toyota, T., Owada, Y., Hashimoto, K., Ishitsuka, Y., Ohba, H., Iwayama, Y., Itokawa, M., Nakata, A., Hayashi, T., Maekawa, M., Ohnishi, T., Yamada, K., Kondo, H., Osumi, N., Yoshikawa, T.
- Organizer
  The 36th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-19390301
[Presentation] Prevention of psychosis at adult by early intervention with D-serine.
- Author(s)
  Hashimoto K
- Organizer
  The XVI World Congress of Psychiartry (2014WPA)
- Place of Presentation
  Convention Center (Madrid, Spain)
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] Clinical implications of sigma-1 receptor chaperone agonists. In Symposium 5: Sigma-1 Receptor Chaperone and Neuroprotection.
- Author(s)
  Hashimoto K
- Organizer
  The 12th Meeting of the Asian-Pacific Society for Neurochemistry (2014APSN)
- Place of Presentation
  Howard Plaza Hotel (台湾高雄市)
- Year and Date
  2014-08-24 – 2014-08-26
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] Role of BDNF-TrkB signaling in depression-lioke behavior in mice after withdrawal from repeated administration of methamphetamine.
- Author(s)
  Ren Q, Ma M, Yang C, Yao W, Zhang JC, Hashimoto K.
- Organizer
  The 44th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Convention Center (Washington DC, USA)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PLANNED-24116006
[Presentation] 覚せい剤の繰り返し投与後のうつ症状におけるBDNF-TrkBシグナルの役割．
- Author(s)
  任乾、馬敏、張継春、楊春、橋本謙二
- Organizer
  平成26年度アルコール・薬物依存関連学会合同学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-10-03 – 2014-10-04
- Data Source
  KAKENHI-PLANNED-24116006
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1. IYO Masaomi (50191903)

# of Collaborated Projects: 8 results

# of Collaborated Products: 28 results
2. SHIMIZU Eiji (00292699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. ISHIMA Tamaki (00597130)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. FUJITA Yuko (40623591)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. Tanaka Mami (90600198)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. HAN MEI

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. SASAKI Tsukasa (50235256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. AOKI Shigeki (80222470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. ABE Osamu (50302716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. YAMADA Haruyasu (70359610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. FUJISAKI Mihisa (30361447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. FUKAMI Goro (70361433)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. MORI Hisashi (00239617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
14. YOSHIKAWA Takeo (30249958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
15. 幡野雅彦 (20208523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. KASAI Kiyoto (80322056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. KITAGAWA Motoo (40262026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TANIGAKI Kenji (70362473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. ZHANG Ji-chun (00733320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. KIM Yoshiharu (60225117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAKAJIMA Satomi (20285753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Kida Satoshi (80301547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. TOMITA Hiroaki (90295064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NAWA Hiroyuki (50183083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 村松喬 (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 関根吉統 (70324358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 呉勁 (20375512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 廣瀬謙造 (00292730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 加藤忠史 (30214381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 岩本和也 (40342753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 林朗子 (60415271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. OHNISHI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. TOYOSHIMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 治徳大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 山田和男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 前川素子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 豊田倫子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hashimoto Kenji 橋本 謙二

HASHIMOTO Kenji 橋本 謙二

橋本 謙二 ハシモト ケンジ

Research Projects

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Co-Researchers

Understanding of biological mechanisms of resilience based on gut-brain axisPrincipal Investigator

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Constructive understanding of stress-related psychiatric disorders by brain-gut-microbiota axisPrincipal Investigator

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Study of stress-related psychiatric disorders based on brain-gut axis via vagus nervePrincipal Investigator

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Study of molecular mechanisms underlying antidepressant actions of (R)-ketaminePrincipal Investigator

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Transomics modeling using iPSC of bipolar disorderPrincipal Investigator

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Prevention of schizophrenia based on Keap1-Nrf2 systemPrincipal Investigator

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統合失調症のモデル動物におけるＢＤＮＦ－ＴｒｋＢシグナル系の役割Principal Investigator

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Metabolomics analysis of CSF from bipolar disorder patientsPrincipal Investigator

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統合失調症のモデル動物におけるＢＤＮＦ－ＴｒｋＢシグナル系の役割Principal Investigator

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Molecular mechanism of inflammation-induced depressionPrincipal Investigator

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Hashimoto Kenji 橋本謙二

HASHIMOTO Kenji 橋本謙二

橋本謙二ハシモトケンジ