Shirasawa Senji 白澤専二

… Alternative Names

SHIRASAWA Senji 白澤専二

白澤専二シラサワセンジ

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Researcher Number	10253535
Other IDs
External Links
Affiliation (Current)	2025: 福岡大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 福岡大学, 医学部, 教授 2017 – 2021: 福岡大学, 医学部, 教授 2014: 福岡大学, 医学部, 教授 2014: 福岡大学, 大学院医学研究科, 教授 2014: 福岡大学医学部, 細胞生物学, 教授 … More 2006 – 2012: 福岡大学, 医学部, 教授 2004 – 2005: International Medical Center of Japan, Research Institute, Director, 臨床病理研究部, 部長 2003: RESEARCH INSTITUTE, INTERNATIONAL MEDICAL CENTER OF JAPAN, DEPARTMENT OF PATHOLOGY, DIRECTOR, 部長 2001 – 2003: 国立国際医療センター, 研究所, 部長 1996 – 2000: 九州大学, 生体防御医学研究所, 助手 1993: 九州大学, 生体防御医学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Human genetics / Basic Section 50010:Tumor biology-related / Human genetics Except Principal Investigator Immunology / Basic Section 50010:Tumor biology-related / Biological Sciences / Tumor biology / 内分泌・代謝学 / Thoracic surgery / Experimental pathology / Tumor biology / Experimental pathology
Keywords	Principal Investigator ZFAT / SNP / 自己免疫疾患 / 自己免疫性甲状腺疾患 / 相関解析 / B細胞 / Mig-6 / 遺伝子欠損マウス / epiregulin / Ki-ras … More / 疾患感受性遺伝子 / マイクロサテライトマーカー / 罹患同胞対法 / Graves病 / 橋本病 / 甲状腺 / がん関連遺伝子 / 大腸癌 / DNA損傷修復 / ゲノム制御 / 癌 / びまん性大細胞型B細胞リンパ腫 / DNAダメージ修復 / 細胞周期 / antisense RNA / association / linkage / affected sib-pairs / microsatellite marker / susceptibility gene / AITD / アンチセンスRNA / 連鎖解析 / 罹患同胞対 / SNPs / 遺伝子ネットワーク / バセドウ病 / Tespa1 / 転写制御因子 / 遺伝子改変マウス / モノクローナル抗体 / モノクロナール抗体 / 発現アレイ解析 / ChIP / ネットワーク / 転写因子 / 自己免疫性甲状腺疾患(AITD) / 癌関連遺伝子 / p53 / 大腸がん / インフォームドコンセント / シグナル伝達 / K-ras … More Except Principal Investigator HLA / KRAS / MHC / 3次元培養 / ZFAT / 低分子化合物 / TCR / HLA-DR / トランスジェニックマウス / 大腸癌 / SNPs / 正の選択 / 胸腺内T細胞分化 / 自己免疫性甲状腺疾患 / CTLA-4 / 自己抗原ペプチド / HLA-B27 / HLA-A2 / スギ花粉症 / T細胞 / ３次元培養 / SNP / 疾患感受性遺伝子 / 相関解析 / ペプチド複合体 / 単一MHC / T細胞受容体 / 肺癌 / エクソソーム / エンドサイトーシス / シャペロン / 癌免疫微少環境 / PMCD / VDAC / BiP / TAM / ゴルジ体 / 薬剤抵抗性 / KDELR / マクロファージ / PMC / 免疫チェックポイント / 免役チェックポイント / 細胞内小器官 / 免疫逃避 / 化合物スクリーニング / Antisense RNA / B cell / association study / Microsatellite markers / Disease susceptibility genes / Autoimmune thyroid disease (AITD) / ゲノム / グレーブス病 / 全ゲノムスキャン / 罹患同胞対法 / 連鎖解析 / 橋本病 / Graves病 / マイクロサテライトマーカー / アンチセンスRNA / B細胞 / マイクロサテライト(MS)マーカー / autoimmunity / positive and negative selection / antigenic peptides / T cell receptor / CDR3 / T細胞レパートリー / 自己免疫 / 正と負の選択 / 抗原ペプチド / 主要組織適合抗原 / Thy1 molecule / positive selection / self peptides / CD4^+CD8^+ thymocytes / T cell differentiation / Thy-1 / アポトーシス / ペプチド複合体相互作用 / TCR-MHC / 単クローン抗体 / Thy1分子 / CD4^+CD8^+胸腺細胞 / autoimmune thyroid disease / TSH receptor / microsatellite / genetic factor / Graves'disease / バセドウ病 / TSH受容体 / マイクロサテライト多型 / 遺伝因子 / パセドウ病 / xenogeneic response / allogeneic response / transgenic mouse / 異種MLR / HLA-DQ6 / 移植 / ゼノ反応性 / アロ反応性 / antigen / peptide / HLA-DP antigen / allergy / HLA-DP / GvH病 / アレルギー / 自己免疫疾患 / 抗原 / ペプチド / cedar pollinosis / Hepatitis B vaccine / immune regulation / T細胞エピトープ / HLA結合ペプチド / HLA-A遺伝子 / HBs抗原 / 溶連菌M蛋白 / トランスジェニックスマウス / DNAタイピング / HLA-B52 / HLA-B51 / B型肝炎ワクチン / 免疫制御 / 末梢分泌型miRNA / 変異KRAS / 縦隔リンパ節サンプル / 腫瘍組織サンプル / 患者血清サンプル / 微小浸潤肺癌 / 微小浸潤癌 / micropapillary pattern / 大腸がん / フィールドエフェクト / 薬剤スクリーニング / 微小環境 / SLE / ZEAT / FCRL3 / リンパ球 / 転写制御因子 / 遺伝子改変マウス / 自己免疫性甲状腺疾患(AITD) / T細胞の選択 / 細胞傷害性T細胞 / 細胞周期 / 細胞接着 / 化学発癌 / 癌治療 / ゲノム医学 / 構造生物学 / シグナル伝達 / ウイルス発癌 / 海外派遣 / 国際学術 / 細胞傷害生T細胞 / HLA結合ペプチドライブラリー Less

Development of a novel cancer therapy utilizing the intracellular and extracellular cycle of the chaperone complex controlled by mutant KRAS
- Principal Investigator
  
  角田俊之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka University
ZFATによるゲノム制御機構とその破綻による細胞癌化メカニズムの解明Principal Investigator
- Principal Investigator
  
  白澤専二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka University
Control of KRAS signals in cancer-immune microenvironment
- Principal Investigator
  
  Tsunoda Toshiyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka University
Elucidation of in vivo-like signal regulated by mutated KRAS in colorectal cancer spheroid and development of inhibitor.
- Principal Investigator
  
  Tsunoda Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka University
Elucidation of the mechanism for regulating microenvironment and cancer development by mutant KRAS
- Principal Investigator
  
  Tsunoda Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Fukuoka University
Elucidation of Field Effect in Colorectal Cancer with Mutant KRAS
- Principal Investigator
  
  TSUNODA Toshiyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Fukuoka University
Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse model
- Principal Investigator
  
  DOI Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fukuoka University
Analyse of peripheral secreted microRNA controlled by mutations KRAS in lung cancer.
- Principal Investigator
  
  YOSHIDA Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Fukuoka University
Elucidation of functions and molecular mechanisms ofimmune-related transcription regulatory factors in life sciencesPrincipal Investigator
- Principal Investigator
  
  SHIRASAWA Senji
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Fukuoka University
Immunogenetic Analysis of Autoimmune Thyroid Diseases
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Research Institute, International Medical Center of Japan
Elucidation of the immune-related genes regulated by ZFATPrincipal Investigator
- Principal Investigator
  
  SHIRASAWA Senji
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Fukuoka University
  Research Institute, International Medical Center of Japan
Identification of autoimmune thyroid disease susceptibility genes
- Principal Investigator
  
  HARADA Haruhito, 山本健
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  International Medical Center of Japan
  Kyushu University
変異Ki-Rasにより発現制御される癌関連遺伝子の同定・機能解析Principal Investigator
- Principal Investigator
  
  白澤専二
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Research Institute, International Medical Center of Japan
橋本病における疾患感受性遺伝子の同定Principal Investigator
- Principal Investigator
  
  白澤専二
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
変異Ki-Rasにより発現制御される新規がん関連遺伝子の単離機能解析Principal Investigator
- Principal Investigator
  
  白澤専二
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
GENETIC ANALYSIS ON AUTOIMMUNE THYROID DISEASEPrincipal Investigator
- Principal Investigator
  
  SHIRASAWA Senji
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  RESEARCH INSTITUTE, INTERNATIONAL MEDICAL CENTER OF JAPAN
  Kyushu University
遺伝子標的法を用いた新規がん関連遺伝子の同定および機能解析Principal Investigator
- Principal Investigator
  
  白澤専二
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
Identification of the ligand recognized by a mAb specific for CD4^+CD8^+ thymocyte
- Principal Investigator
  
  FUKUI Yoshinori
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
Molecular basis for T cell repertoire selection in the thymus
- Principal Investigator
  
  FUKUI Yoshinori, 笹月健彦
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
Research into the Genetics of Autoimmune Thyroid Disease
- Principal Investigator
  
  AKAMIZU Takashi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
アメリカ大陸を中心としたがん研究先進グループとの研究交流
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
HLA結合ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の解明
- Principal Investigator
  
  上川路信博
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
胸腺内T細胞分化におけるTCR・MHC/ペプチド複合体相互作用の生化学的解析
- Principal Investigator
  
  福井宣規
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
HLA結合性ペプチドライブラリーを用いた癌特異的T細胞の誘導及び癌抗原群の同定
- Principal Investigator
  
  KAMIKAWAJI Nobuhiro
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Development of model mouse for human immune system.
- Principal Investigator
  
  KAMIKAWAJI Nobuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
Basic research for the development of antigen specific immunosuppressive therapy using HLA.
- Principal Investigator
  
  KAMIKAWAJI Nobuhiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
Molecular mechanism of immune response requlated by HLA
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY

[Book] 自己免疫性甲状腺疾患ゲノム解析の現状と転写関連分子ZFAT2010
- Author(s)
  中林一彦,白澤専二
- Publisher
  小宮山印刷工業株式会社
- Data Source
  KAKENHI-PROJECT-21390102
[Book] 疾患ゲノム解析の現状と展望2009
- Author(s)
  中林一彦,田嶋敦,白澤専二
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-21390102
[Book] 疾患ゲノム解析の現状と展望「日本臨床」 Vol.67, No.3 : 469-4762009
- Author(s)
  中林一彦, 田嶋敦, 白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] 自己免疫性甲状腺疾患-感受性遺伝子群の探索と機能解析2009
- Author(s)
  中林一彦,白澤専二
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21390102
[Book] 自己免疫性甲状腺疾患の遺伝要因と環境要因2009
- Author(s)
  中林一彦,白澤専二
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-21390102
[Book] 「よくわかる甲状腺疾患のすべて改訂第2版」(担当:自己免疫性甲状腺疾患の遺伝要因と環境要因)2009
- Author(s)
  中林一彦、白澤専二
- Total Pages
  514
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-17019069
[Book] よくわかる甲状腺疾患のすべて改訂第2版(自己免疫性甲状腺疾患の遺伝要因と環境要因)2009
- Author(s)
  中林一彦, 白澤専二
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-17019069
[Book] ゲノム医科学NOW(自己免疫性甲状腺疾患の疾患感受性遺伝子探査)2006
- Author(s)
  白澤専二, 笹月健彦
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-17019069
[Book] 自己免疫性甲状腺疾患感受性遺伝子の探索「日本臨床」 Vol.64, No.12 : 2208-22142006
- Author(s)
  白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] 自己免疫性甲状腺疾患の疾患感受性遺伝子探査「ゲノム医科学NOW」 135-1522006
- Author(s)
  白澤専二, 笹月健彦
- Data Source
  KAKENHI-PROJECT-17390101
[Book] ゲノムワイド研究と膠原病・自己免疫疾患「リウマチ・膠原病最新トピックス -変わりゆく研究と診療」(竹原和彦, 佐藤伸一, 桑名正隆編, 診断と治療社) 6-92005
- Author(s)
  山田亮, 白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] リウマチ・膠原病最新トピックス-変わりゆく研究と診療(竹原和彦, 佐藤伸一, 桑名正隆編, ゲノムワイド研究と膠原病・自己免疫疾患)2005
- Author(s)
  山田亮, 白澤専二
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-17019069
[Book] 自己免疫性甲状腺疾患の疾患感受性遺伝子「Medical Practice」(M.P. 内科総合誌) : Vol.22 no.4, 633-6352005
- Author(s)
  白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] 自己免疫性甲状腺疾患「最新医学」第60巻9月増刊号(「臨床遺伝子学'05-多因子遺伝病研究の最前線-」) 2087-20942005
- Author(s)
  白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] 自己免疫性甲状腺疾患感受性遺伝子とその探索「ホルモンと臨床」 Vol.53, No.9, 11-162005
- Author(s)
  白澤専二
- Data Source
  KAKENHI-PROJECT-17390101
[Book] 自己免疫性甲状腺疾患感受性遺伝子の探索「蛋白質・核酸・酵素/増刊号ゲノムから生命システムへ」 Vol.50 No.16, 2097-21022005
- Author(s)
  白澤専二, 笹月健彦
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment2021
- Author(s)
  Kushima Hisako、Tsunoda Toshiyuki、Matsumoto Taichi、Kinoshita Yoshiaki、Izumikawa Koichi、Shirasawa Senji、Fujita Masaki、Ishii Hiroshi
- Journal Title
  
  Microorganisms
  
  Volume: 9 Issue: 7 Pages: 1435-1435
- DOI
  10.3390/microorganisms9071435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08840, KAKENHI-PROJECT-21K06703, KAKENHI-PROJECT-21K07161, KAKENHI-PROJECT-18K15154
[Journal Article] The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes2021
- Author(s)
  Shuhei Ishikura Masayoshi Nagai Toshiyuki Tsunoda Kensuke Nishi Yoko Tanaka Midori Koyanagi Senji Shirasawa
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: NA Issue: 6 Pages: 626-638
- DOI
  10.1002/jcb.29890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07317, KAKENHI-PROJECT-21K07161
[Journal Article] Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP12021
- Author(s)
  Kandasamy Palanivel、Zlobec Inti、Nydegger Damian T.、Pujol‐Gimenez Jonai、Bhardwaj Rajesh、Shirasawa Senji、Tsunoda Toshiyuki、Hediger Matthias A.
- Journal Title
  
  Molecular Oncology
  
  Volume: 15 Issue: 10 Pages: 2782-2800
- DOI
  10.1002/1878-0261.12999
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07161
[Journal Article] CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA2021
- Author(s)
  Shuhei Ishikura, Kazumasa Yoshida, Sayuri Hashimoto, Kazuhiko Nakabayashi, Toshiyuki Tsunoda, Senji Shirasawa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297(4) Issue: 4 Pages: 101213-101213
- DOI
  10.1016/j.jbc.2021.101213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07317, KAKENHI-PROJECT-21K07161
[Journal Article] Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products2021
- Author(s)
  HASHIMOTO SAYURI、NAGAI MASAYOSHI、NISHI KENSUKE、ISHIKURA SHUHEI、NAKABAYASHI KAZUHIKO、YAZAKI RYO、OHSHIMA TAKASHI、SUENAGA MASAHIKO、SHIRASAWA SENJI、TSUNODA TOSHIYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 8 Pages: 4061-4070
- DOI
  10.21873/anticanres.15207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07161
[Journal Article] Mutant KRAS Promotes NKG2D+ T Cell Infiltration and CD155 Dependent Immune Evasion2020
- Author(s)
  NISHI KENSUKE、ISHIKURA SHUHEI、UMEBAYASHI MASAYO、MORISAKI TAKASHI、INOZUME TAKASHI、KINUGASA TETSUSHI、AOKI MIKIKO、NIMURA SATOSHI、SWAIN ANTHONY、YOSHIDA YOICHIRO、HASEGAWA SUGURU、NABESHIMA KAZUKI、SAKATA TOSHIFUMI、SHIRASAWA SENJI、TSUNODA TOSHIYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 8 Pages: 4663-4674
- DOI
  10.21873/anticanres.14465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-20K09114, KAKENHI-PROJECT-18K07215
[Journal Article] MK615 Suppresses Hypoxia Tolerance by Up-regulation of E-cadherin in Colorectal Cancer Cells With Mutant KRAS2020
- Author(s)
  NISHI KENSUKE、TSUNODA TOSHIYUKI、UCHIDA YOSHINORI、SUETA TAKAYUKI、SAWATSUBASHI MOTOHIRO、YAMANO TAKAFUMI、HASHIGUCHI YASUKO、SWAIN ANTHONY、SHIRASAWA SENJI、SAKATA TOSHIFUMI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 8 Pages: 4687-4694
- DOI
  10.21873/anticanres.14468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07215
[Journal Article] Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation2019
- Author(s)
  Charitou Theodosia、Srihari Sriganesh、Lynn Miriam A.、Jarboui Mohamed-Ali、Fasterius Erik、Moldovan Max、Shirasawa Senji、Tsunoda Toshiyuki、Ueffing Marius、Xie Jianling、Xin Jin、Wang Xuemin、Proud Christopher G.、Boldt Karsten、Al-Khalili Szigyarto Cristina、Kolch Walter、Lynn David J.
- Journal Title
  
  British Journal of Cancer
  
  Volume: 121 Issue: 1 Pages: 37-50
- DOI
  10.1038/s41416-019-0477-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07215, KAKENHI-PROJECT-17K10659
[Journal Article] Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver2019
- Author(s)
  DOI KEIKO、TSUNODA TOSHIYUKI、KOYANAGI MIDORI、TANAKA YOKO、YAMANO SHIORI、FUJIKANE AYA、NISHI KENSUKE、ISHIKURA SHUHEI、SHIRASAWA SENJI
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 8 Pages: 4495-4502
- DOI
  10.21873/anticanres.13625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07215
[Journal Article] A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells2019
- Author(s)
  Sawata Yuuga、Matsukawa Taiji、Doi Satoshi、Tsunoda Toshiyuki、Arikawa Nagisa、Matsunaga Natsumi、Ohnuki Koichiro、Shirasawa Senji、Kotake Yojiro
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 462 Issue: 1-2 Pages: 25-31
- DOI
  10.1007/s11010-019-03606-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07215, KAKENHI-PROJECT-17K07184
[Journal Article] Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture2018
- Author(s)
  Luo, H.; Nishi, K.; Ishikura, S.; Swain, A.; Morishige, N.; Yazaki, R.; Ohshima, T.; Shirasawa, S.; Tsunoda, T.
- Journal Title
  
  Anticancer research
  
  Volume: 38 Issue: 7 Pages: 4247-4256
- DOI
  10.21873/anticanres.12721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05846, KAKENHI-PROJECT-17H03972, KAKENHI-PROJECT-18K07215
[Journal Article] The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation.2018
- Author(s)
  Naemura M, Kuroki M, Tsunoda T, Arikawa N, Sawata Y, Shirasawa S, Kotake Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Pages: 77-81
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07215
[Journal Article] Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line2018
- Author(s)
  Inozume T, Tsunoda T, Morisaki T, Harada K, Shirasawa S, Kawamura T
- Journal Title
  
  Journal of Dermatology
  
  Volume: 45 Issue: 12 Pages: 1434-1439
- DOI
  10.1111/1346-8138.14651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10148, KAKENHI-PROJECT-18K07215
[Journal Article] A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.2018
- Author(s)
  Okamoto H, Matsukawa T, Doi S, Tsunoda T, Sawata Y, Naemura M, Ohnuki K, Shirasawa S, Kotake Y
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 442(1-2) Issue: 1-2 Pages: 39-45
- DOI
  10.1007/s11010-017-3191-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07184, KAKENHI-PROJECT-18K07215
[Journal Article] The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation2018
- Author(s)
  Naemura M, Kuroki M, Tsunoda T, Arikawa N, Sawata Y, Shirasawa S, Kotake Y.
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 1 Pages: 77-81
- DOI
  10.21873/anticanres.12194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] Zfat expression in ZsGreen reporter gene knoc;in mice: Implications for a novel function of Zfat in definitive erythropoiesis.2018
- Author(s)
  Tsunoda T, Doi K, Ishikura S, Luo H, Nishi K, Matsuzaki H, Koyanagi M, Tanaka Y, Okamura T, Shirasawa S
- Journal Title
  
  Int J Mol Med.
  
  Volume: 42 Pages: 2595-2603
- DOI
  10.3892/ijmm.2018.3806
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08166, KAKENHI-PROJECT-18K07215
[Journal Article] Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS2017
- Author(s)
  Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L, Baillie GS, Sakata T, Shirasawa S, Tsunoda T.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 7 Pages: 3833-3839
- DOI
  10.21873/anticanres.11762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line2017
- Author(s)
  Nishi Kensuke、Iwaihara Yuri、Tsunoda Toshiyuki、Doi Keiko、Sakata Toshifumi、Shirasawa Senji、Ishikura Shuhei
- Journal Title
  
  Cell Death & Disease
  
  Volume: 8 Issue: 12 Pages: 3218-3231
- DOI
  10.1038/s41419-017-0006-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids2017
- Author(s)
  12.Nishi K, Luo H, Nakabayashi K, Doi K, Ishikura S, Iwaihara Y, Yoshida Y, Tanisawa K, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M, Sakata T, Shirasawa S, Tsunoda T
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 7 Pages: 3855-3862
- DOI
  10.21873/anticanres.11765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H01872, KAKENHI-PROJECT-15K06847
[Journal Article] The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.2016
- Author(s)
  Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura　T, Tsunoda T, Shirasawa S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 291(29) Issue: 29 Pages: 15282-91
- DOI
  10.1074/jbc.m116.723734
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
[Journal Article] Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.2016
- Author(s)
  Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, Kawai T, Tanaka Y, Iwaihara Y, Luo H, Nishi K, Okamura T, Shirasawa S.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1859(11) Issue: 11 Pages: 1398-1410
- DOI
  10.1016/j.bbagrm.2016.08.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
[Journal Article] Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells.2016
- Author(s)
  Luo H, Umebayashi M, Doi K, Morisaki T, Shirasawa S, Tsunoda T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 36(7) Pages: 3585-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture2016
- Author(s)
  Naemura M, Tsunoda T, Inoue Y, Okamoto H, Shirakawa S, and Kotake Y
- Journal Title
  
  Molecular and cellular biochemistry.
  
  Volume: 412 Issue: 1-2 Pages: 141-146
- DOI
  10.1007/s11010-015-2618-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430127, KAKENHI-PROJECT-15K06847
[Journal Article] Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.2016
- Author(s)
  Lapa GB, Tsunoda T, Shirasawa S, Baryshnikova MA, Evseev GG, Afanasyeva DA, Chigorina EA.
- Journal Title
  
  Chem Biol Drug Des.
  
  Volume: 87(4) Issue: 4 Pages: 575-82
- DOI
  10.1111/cbdd.12691
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.2015
- Author(s)
  Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.
- Journal Title
  
  J Cell Biochem.
  
  Volume: 16(1) Issue: 1 Pages: 149-57
- DOI
  10.1002/jcb.24954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501322, KAKENHI-PROJECT-24590465, KAKENHI-PROJECT-15K08166
[Journal Article] Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules.2015
- Author(s)
  Tsunoda T, Ishikura S, Doi K, Iwaihara Y, Hidesima H, Luo H, Hirose Y, Shirasawa S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35(8) Pages: 4453-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.2015
- Author(s)
  Iwaihara Y, Ishikura S, Doi K, Tsunoda T, Fujimoto T, Okamura T, Shirasawa S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35(8) Pages: 4419-23
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06847
[Journal Article] Oncogenic Ras influences the expression of multiple lncRNAs.2014
- Author(s)
  Kotake Y, Naemura M, Kitagawa K, Niida H, Tsunoda T, Shirasawa S, Kitagawa M.
- Journal Title
  
  Cytotechnology.
  
  Volume: Dec.14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.2014
- Author(s)
  Doi K, Ishikura S, Shirasawa S.
- Journal Title
  
  Anticancer Res
  
  Volume: 34 Pages: 4489-4495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590465
[Journal Article] Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.2014
- Author(s)
  Tsunoda T, Ishikura S, Doi K, Matsuzaki H, Iwaihara Y, Shirasawa S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 34(8) Pages: 4551-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.2013
- Author(s)
  Matsuzaki H, Fujimoto T, Tanaka M, Shirasawa S.
- Journal Title
  
  Biochem Bio- phys Res Commun
  
  Volume: 433(3) Issue: 3 Pages: 322-326
- DOI
  10.1016/j.bbrc.2013.02.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24710265
[Journal Article] Tespa1 protein is phosphoryl- ated in response to store-operated calcium entry2013
- Author(s)
  Fujimoto T, Matsuzaki H, Tanaka M, Shirasawa S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 434(1) Issue: 1 Pages: 162-165
- DOI
  10.1016/j.bbrc.2013.02.128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102
[Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013
- Author(s)
  Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 10 Pages: e76254-e76254
- DOI
  10.1371/journal.pone.0076254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590465
[Journal Article] Roles of ZFAT in haematopoiesis, angiogenesis and cancer development.2013
- Author(s)
  Tsunoda T, Shirasawa S.
- Journal Title
  
  Anticancer Res
  
  Volume: 33 Pages: 2833-2837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013
- Author(s)
  Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T and Shirasawa S
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] Tespa1 is a novel IP3R-binding protein in T- and B-lymphocytes2012
- Author(s)
  Matsuzaki H, Shirasawa S
- Journal Title
  
  FEBS Open Bio
  
  Volume: 2 Issue: 1 Pages: 255-259
- DOI
  10.1016/j.fob.2012.08.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24590465
[Journal Article] KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.2012
- Author(s)
  Ota T, Doi K, Fujimoto T, Tanaka Y, Ogawa M, Matsuzaki H, Kuroki M, Miyamoto S, Shirasawa S, Tsunoda T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 32 Pages: 2271-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.2012
- Author(s)
  Tsunoda T.
- Journal Title
  
  Mol Cancer
  
  Volume: 11(1) Issue: 1 Pages: 46-46
- DOI
  10.1186/1476-4598-11-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24501322, KAKENHI-PROJECT-24590465
[Journal Article] ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.2012
- Author(s)
  Doi K, Shirasawa S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 425(1) Issue: 1 Pages: 107-112
- DOI
  10.1016/j.bbrc.2012.07.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24590465, KAKENHI-PLANNED-22133009
[Journal Article] ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.2012
- Author(s)
  Yoshida Y, Tsunoda T, Doi K, Fujimoto T, Tanaka Y, Ota T, Ogawa M, Matsuzaki H, Kuroki M, Iwasaki A, Shirasawa S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 32 Pages: 2301-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501322
[Journal Article] ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts.2011
- Author(s)
  Doi K, Shirasawa S
- Journal Title
  
  Cell MolBiol Lett
  
  Volume: 16(1) Issue: 3 Pages: 89-100
- DOI
  10.1158/0008-5472.can-10-0714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PLANNED-22133009
[Journal Article] Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.2011
- Author(s)
  Nakabayashi K, Shirasawa S
- Journal Title
  
  J Hum Genet
  
  Volume: 56(11) Issue: 11 Pages: 772-778
- DOI
  10.1038/jhg.2011.99
- NAID
  10030661591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-ORGANIZER-22133001, KAKENHI-PLANNED-22133003, KAKENHI-PLANNED-22133009, KAKENHI-PROJECT-23510242
[Journal Article] Immune-related zinc finger gene ZFAT is an essential transcriptional regulator forhematopoietic differentiation in blood islands2010
- Author(s)
  Tsunoda T, Shirasawa S
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 107(32) Issue: 32 Pages: 14199-14204
- DOI
  10.1073/pnas.1002494107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102
[Journal Article] ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model2010
- Author(s)
  Yoshida Y, Shirasawa S
- Journal Title
  
  Cell Mol Biol Lett
  
  Volume: 15(4) Issue: 4 Pages: 541-550
- DOI
  10.2478/s11658-010-0028-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102
[Journal Article] ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells2009
- Author(s)
  Fujimoto T, Doi K, Koyanagi M, Tsunoda T, Takashima Y, Yoshida Y, Sasazuki T, Shirasawa S.
- Journal Title
  
  FEBS Lett. 583(3)
  
  Pages: 568-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells.2009
- Author(s)
  Sasazuki T(7番目), Shirasawa S(8番目:全8名)
- Journal Title
  
  FEBS Lett 583(3)
  
  Pages: 568-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes2008
- Author(s)
  0Koyanagi M, Nakabayashi K, Fujimoto T, Gu N, Baba I, Takashima Y, Doi K, Harada H, Kato N, Sasazuki T, Shirasawa S.
- Journal Title
  
  Genomics 91(5)
  
  Pages: 451-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] Functional Analysis of ZFAT through Specific siRNA against ZFAT in Ba/F3 cell Line.2008
- Author(s)
  Shirasawa S(6番目:全6名)
- Journal Title
  
  Med. Bull.(Fukuoka Univ.) 35(4)
  
  Pages: 187-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes.2008
- Author(s)
  Sasazuki T(10番目), Shirasawa S(11番目:全11名)
- Journal Title
  
  Genomics 91(5)
  
  Pages: 451-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] Functional Analysis of ZFAT through Specific siRNA against ZFAT in Ba/F3 cell Line2008
- Author(s)
  Koyanagi M, Doi K, Fujimoto T, Tsunoda T, Takashima Y, Shirasawa S.
- Journal Title
  
  Med.Bull.Fukuoka univ. 35(4)
  
  Pages: 187-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease2005
- Author(s)
  Hiratani H, Bowden DW, Ikegami S, Shirasawa S, Shimizu A, Iwatani Y, Akamizu T.
- Journal Title
  
  J. Clin. Endocrinol. Metab. 90(5)
  
  Pages: 2898-2903
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease.2005
- Author(s)
  Shirasawa S(4番目:全7名)
- Journal Title
  
  J. Clin. Endocrinol. Metab. 90(5)
  
  Pages: 2898-2903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] A functional variant in FcRL3, encoding Fc Receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.2005
- Author(s)
  Shirasawa S(5番目), Sasazuki T(22番目:全23名)
- Journal Title
  
  Nature Genet. 37(5)
  
  Pages: 478-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] A functional variant in FcRL3, encoding Fc Receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities2005
- Author(s)
  Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae S-C, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K.
- Journal Title
  
  Nature Genet. 37(5)
  
  Pages: 478-485
- Data Source
  KAKENHI-PROJECT-17390101
[Journal Article] Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells.2005
- Author(s)
  Sasazuki T(4番目), Shirasawa S(5番目:全5名)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 337(1)
  
  Pages: 271-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019069
[Journal Article] Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage.2004
- Author(s)
  Shirasawa S et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101(38)
  
  Pages: 13921-13926
- Data Source
  KAKENHI-PROJECT-13204066
[Journal Article] SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.2004
- Author(s)
  Shirasawa S et al.
- Journal Title
  
  Human Molecular Genetics 13(19)
  
  Pages: 2221-2231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204066
[Journal Article] Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage.2004
- Author(s)
  Shirasawa S et al.
- Journal Title
  
  Proc. Natl Acad. Sci. USA 101(38)
  
  Pages: 13921-13926
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204066
[Journal Article] 自己免疫性甲状腺疾患感受性遺伝子の解明2003
- Author(s)
  白澤専二
- Journal Title
  
  最新医学 58
  
  Pages: 1649-1656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12307056
[Journal Article] 自己免疫性甲状腺疾患感受性遺伝子の解明AITS-1遺伝子の同定2003
- Author(s)
  白澤専二
- Journal Title
  
  実験医学 21
  
  Pages: 25-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12307056
[Journal Article] 自己免疫性甲状腺疾患とゲノム2002
- Author(s)
  白澤専二
- Journal Title
  
  ゲノム医学 2
  
  Pages: 149-157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12307056
[Journal Article] 自己免疫性甲状腺疾患のゲノム解析2002
- Author(s)
  白澤専二
- Journal Title
  
  医学のあゆみ 202
  
  Pages: 827-832
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12307056
[Patent] ピラゾール誘導体及び医薬組成物2020
- Inventor(s)
  白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
- Industrial Property Rights Holder
  白澤専二、角田俊之、大嶋孝志、矢崎亮、末永正彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-017307
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K07215
[Patent] フェニルテトラヒドロピリドインドール誘導体及び医薬組成物2018
- Inventor(s)
  白澤　専二、角田　俊之、大嶋　孝志、矢崎　亮
- Industrial Property Rights Holder
  白澤　専二、角田　俊之、大嶋　孝志、矢崎　亮
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-147801
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K07215
[Patent] 変異KRAS関連シグナル阻害用組成物2017
- Inventor(s)
  白澤専二、角田俊之
- Industrial Property Rights Holder
  白澤専二、角田俊之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-140139
- Filing Date
  2017
- Acquisition Date
  2017
- Data Source
  KAKENHI-PROJECT-15K06847
[Patent] ZFAT遺伝子発現抑制RNA2008
- Inventor(s)
  白澤専二、藤本崇宏、角田俊之、土井佳子、小柳緑
- Industrial Property Rights Holder
  学校法人福岡大学
- Filing Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-17019069
[Patent] ZFAT遺伝子発現抑制RNA2008
- Inventor(s)
  白澤専二, 他
- Industrial Property Rights Holder
  学校法人福岡大学
- Filing Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-17019069
[Patent] ZFAT遺伝子発現抑制RNA2008
- Inventor(s)
  白澤専二、藤本崇宏、角田俊之、土井佳子、小柳緑
- Industrial Property Rights Holder
  学校法人福岡大学
- Filing Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] セントロメアに生じたDNA２重鎖切断の修復メカニズム2023
- Author(s)
  石倉　周平、吉田　和真、丸田　弦、前岡　尚憲、白澤　専二
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06643
[Presentation] Growth of Tumor with Mutated-KRAS Related Signals are inhibited by a dual VDAC1 and KDELR1 regulator.2021
- Author(s)
  Tsunoda T and Shirasawa S.
- Organizer
  The Third RAS Initiative Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07161
[Presentation] KRASが誘導する発癌性ROSはVDAC1およびKDELR1の2重調節剤により抑制される。2021
- Author(s)
  角田俊之, 西憲祐, 白澤専二．
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07161
[Presentation] VDACおよびKDELRを標的とする低分子化合物STAR2は変異KRAS関連シグナルを抑制する．2020
- Author(s)
  角田俊之, 橋本小百合, 永井正義, 西憲祐, 石倉周平,白澤専二．
- Organizer
  第24回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] 変異KRAS関連シグナルが活性化した癌細胞の増殖はVDAC1およびKDELR1の2重調節剤により抑制される．2020
- Author(s)
  角田俊之, 西憲祐, 白澤専二
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] 変異KRAS関連シグナルが活性化した癌細胞株の増殖を抑制する低毒性化合物2019
- Author(s)
  角田俊之, 西憲祐, 白澤専二
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] 変異KRASはTNK細胞の腫瘍内浸潤とCD155依存的な免疫逃避を誘導する．2019
- Author(s)
  角田俊之, 西憲祐, 石倉周平, 梅林雅代, 森崎隆, 猪爪隆史, 衣笠哲史, 青木光希子, 二村聡, スウェイン・アンソニー, 吉田陽一郎, 長谷川傑, 鍋島一樹, 坂田俊文, 白澤専二．
- Organizer
  第23回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] KRAS変異大腸癌細胞塊とCytokine-activated killer細胞の共培養系におけるCD155/TIGIT経路の役割の解析2018
- Author(s)
  角田俊之, 西憲祐, 羅昊, 梅林雅代, 森崎隆, 白澤専二
- Organizer
  第22回バイオ治療法研究会学術集会，東京，12月8日
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] 3-deaza-cytarabineは3次元浮遊培養において変異KRAS陽性大腸癌細胞塊の増殖を抑制する2018
- Author(s)
  角田俊之, 西憲祐, 白澤専二
- Organizer
  第77回日本癌学会学術総会，大阪，9月27-29日
- Data Source
  KAKENHI-PROJECT-18K07215
[Presentation] 三次元共培養法を用いた、KRAS変異大腸癌に対するCytokine-activated killer細胞と免疫チェックポイント阻害薬併用効果の検討2017
- Author(s)
  西　憲祐、羅　昊、梅林　雅代、森崎　隆、白澤専二、角田俊之
- Organizer
  第21回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] PDE4 阻害剤アプレミラストは変異KRAS 陽性大腸癌細胞株にアポトーシスを誘導する．2017
- Author(s)
  角田俊之, 白澤専二
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] レスベラトロールはAKTを脱リン酸化しBRAF変異メラノーマのベムラフェニブ耐性化を抑制する2016
- Author(s)
  角田俊之, 白澤専二
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] PDE4阻害剤Apremilastの抗腫瘍効果の検討2016
- Author(s)
  羅　昊、西　憲祐、角田俊之、白澤専二
- Organizer
  第20回バイオ治療法研究会学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] ALPK2のQ1853E変異は大腸癌の造腫瘍活性を促進する2016
- Author(s)
  西　憲祐、羅　昊、角田俊之、白澤専二
- Organizer
  第20回バイオ治療法研究会学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] 変異KRAS制御シグナル関連分子を標的とする薬剤をスクリーニングするための３次元浮遊培養システムの構築2015
- Author(s)
  角田俊之, 白澤専二
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋　名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] 3次元特異的変異KRAS制御分子KRAPの造腫瘍メカニズムの解明2015
- Author(s)
  角田俊之,土井佳子, 白澤専二
- Organizer
  第19回バイオ治療法研究会学術集会
- Place of Presentation
  東京　東京理科大学　森戸記念館
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] 大腸癌造腫瘍能におけるALPK2遺伝子変異の機能的解析2015
- Author(s)
  角田俊之, 新井冨生、森聖二郎、沢辺元司、村松正明、田中雅嗣、白澤専二
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  東京　新宿　京王プラザホテル
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K06847
[Presentation] 膵臓癌のジェムシタビン耐性化には３次元特異的変異KRAS制御分子群が関与する2014
- Author(s)
  角田俊之, 佐々木隆光, 土井佳子, 石倉周平, 白澤専二
- Organizer
  第18回バイオ治療法研究会学術集会
- Place of Presentation
  高松
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] 大腸癌スフェロイドにおける変異KRASカスケードの解明とその応用2014
- Author(s)
  角田俊之, 白澤専二．
- Organizer
  第2回細胞凝集研究会
- Place of Presentation
  福岡
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] 変異KRASが制御する３次元特異的癌増殖経路阻害のためのドラッグスクリーニング法の開発2014
- Author(s)
  角田俊之, 土井佳子, 石倉周平, 白澤専二.
- Organizer
  化学療法基盤支援活動第３回シンポジウム
- Place of Presentation
  名護
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進2014
- Author(s)
  土井佳子、石倉周平、岡村匡史、角田俊之、田中陽子、白澤専二
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  船堀
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-24590465
[Presentation] 大腸癌における３次元特異的変異KRAS制御microRNAの解析2013
- Author(s)
  角田俊之, 土井佳子, 石倉周平, 白澤専二
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] PDE4の抑制は3次元大腸クリプトモデルにおいてアポトーシスとAKTの脱リン酸化を誘導する.2013
- Author(s)
  角田俊之, 白澤専二
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] 転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明2013
- Author(s)
  土井佳子、小川雅弘、岡村匡史、石倉周平、角田俊之、田中陽子、白澤専二
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590465
[Presentation] ZFATは末梢T細胞の恒常性とT細胞レセプター刺激に対する増殖応答性に関与する2012
- Author(s)
  角田俊之,土井佳子,黒木政秀,白澤専二
- Organizer
  第16回バイオ治療法研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 癌・代謝関連遺伝子KRAPの細胞内カルシウムイオン制御機構に関する研究2012
- Author(s)
  藤本崇宏,白澤専二
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 遺伝子改変マウスを利用した転写制御分子ZFATの機能解明2012
- Author(s)
  土井佳子,白澤専二
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] KRAP・ZFATを対象とした生命科学における基盤研究と創薬シーズの探索2011
- Author(s)
  白澤専二
- Organizer
  第39回薬物活性シンポジウム
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] KRAP・ZFATを対象とした生命科学における基盤研究と創薬シーズの探索2011
- Author(s)
  白澤専二
- Organizer
  第39回薬物活性シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 遺伝子欠損マウスを利用した新規転写制御因子ZFATの機能解明2010
- Author(s)
  土井佳子、白澤専二
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  埼玉
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 生命科学と創薬開発のための基礎研究2010
- Author(s)
  白澤専二
- Organizer
  第14回バイオ治療法研究会学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] Genome-Wide Association Studies(GWAS)on AITD and AITD susceptibility genes2010
- Author(s)
  白澤専二
- Organizer
  14th International Congress of Endocrinology(ICE2010)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] Genetic risk factors for autoimmune thyroid disease and a novel transcriptional regulator ZFAT.2010
- Author(s)
  Shirasawa S
- Organizer
  Thyroid Satellite Symposium of 14th International Congress of Endocrinology(ICE2010)(シンポジウム)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-17019069
[Presentation] Genetic risk factors for autoimmune thyroid disease and a novel transcriptional regulator ZFAT.2010
- Author(s)
  白澤専二
- Organizer
  Thyroid Satellite Symposium of 14th International Congress of Endocrinology (ICE2010)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-17019069
[Presentation] 転写制御因子ZFATの機能および転写ネットワークに関する研究2009
- Author(s)
  土井佳子,白澤専二
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 自己免疫性甲状腺疾患のゲノム解析とZFAT2009
- Author(s)
  白澤専二
- Organizer
  第37回日本臨床免疫学会総会(シンポジウム)
- Place of Presentation
  東京
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-17019069
[Presentation] 自己免疫性甲状腺疾患のゲノム解析とZFAT2009
- Author(s)
  白澤専二
- Organizer
  第37回日本臨床免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-17019069
[Presentation] 自己免疫性甲状腺疾患ゲノム解析の現状と転写関連分子ZFAT2009
- Author(s)
  白澤専二,中林一彦
- Organizer
  第37回日本臨床免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells2009
- Author(s)
  高島康郎, 白澤専二
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21390102
[Presentation] 生命科学と創薬シーズの探索(招待口演-国内学会・研究会)2008
- Author(s)
  白澤専二
- Organizer
  第40回日本臨床分子形態学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] BおよびT細胞におけるZFATの発現とその制御因子の解析2008
- Author(s)
  角田俊之, 小柳緑, 藤本崇宏, 馬場賀, 中林一彦, 土井佳子, 高島康郎, 吉田康浩, 笹月健彦, 白澤専二
- Organizer
  日本人類遺伝学会第52回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] Genome-wide survey of ZFAT-regulated genes in antigen-primed CD4+ T cell2008
- Author(s)
  Yasuo Takashima, Midori Koyanagi, Keiko Doi, Iwai Baba, Yoko Tanaka, Toshiyuki Tsunoda, Takahiro Fujimoto, Kazuhiko Nakabayashi, Takehiko Sasazuki, Senji Shirasawa
- Organizer
  第31回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] 免疫系転写関連因子ZFATの転写ネットワークの解明2007
- Author(s)
  中林一彦, 藤本崇弘, 馬場賀, 小柳緑, 顧寧, 土井佳子, 加藤規弘, 笹月健彦, 白澤専二
- Organizer
  日本人類遺伝学会第52回大会
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] Genome Analysis on Autoimmune Thyroid Disease(招待口演-国際学会・研究会)2006
- Author(s)
  Shirasawa S.
- Organizer
  The 6^<th> HUGO-Pacific Meeting & the 7^<th> Asia-Pacific Conference on Human Genetics
- Place of Presentation
  Taipei
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] 新規免疫系転写因子 ZFAT・TR-ZFATを軸とする転写ネットワークとその生理機能の解明2006
- Author(s)
  中林一彦、馬場賀、藤本崇弘、加藤規弘,笹月健彦、白澤専二
- Organizer
  日本人類遺伝学会第51回大会
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] Epiregulin欠損マウスにおけるアトピー様皮膚炎発症の分子機構(招待口演-国内学会・研究会)2005
- Author(s)
  白澤専二
- Organizer
  第55回日本アレルギー学会総会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] 自己免疫性甲状腺疾患のゲノム解析2005
- Author(s)
  白澤専二, 石川繭子, 杉山滋, 中林一彦, 野本順子, 赤水尚史, 伴良行, 青木正幸, 山本健, 笹月健彦
- Organizer
  日本人類遺伝学会第50回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] 自己免疫性甲状腺疾患(AITD)感受性候補遺伝子ZFATの同定と機能解析2005
- Author(s)
  中林一彦, 杉山滋, 馬場賀, 加藤規弘, 赤水尚志, 山本健, 笹月健彦, 白澤専二
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17390101
[Presentation] 大腸癌spheroidに対するPDE4阻害剤の効果検討
- Author(s)
  角田俊之, 太田岳晴, 土井佳子, 石倉周平, 白澤専二
- Organizer
  第17回バイオ治療法研究会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] 変異KRAS陽性癌を標的とする薬剤開発のためのスクリーニングシステム
- Author(s)
  角田俊之, 白澤専二．
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501322
[Presentation] KRAS制御分子ALPK2の造腫瘍メカニズムの解析
- Author(s)
  角田俊之, 土井佳子, 石倉周平, 白澤専二
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  船堀
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24501322

1. FUKUI Yoshinori (60243961)

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Shirasawa Senji 白澤 専二

SHIRASAWA Senji 白澤 専二

白澤 専二 シラサワ センジ

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ZFATによるゲノム制御機構とその破綻による細胞癌化メカニズムの解明Principal Investigator

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Elucidation of functions and molecular mechanisms ofimmune-related transcription regulatory factors in life sciencesPrincipal Investigator

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Elucidation of the immune-related genes regulated by ZFATPrincipal Investigator

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変異Ki-Rasにより発現制御される癌関連遺伝子の同定・機能解析Principal Investigator

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橋本病における疾患感受性遺伝子の同定Principal Investigator

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Shirasawa Senji 白澤専二

SHIRASAWA Senji 白澤専二

白澤専二シラサワセンジ