KAWAHARA Kohichi 川原浩一

… Alternative Names

川原浩一カワハラコウイチ

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Researcher Number	10347015
Other IDs
Affiliation (Current)	2025: 新潟薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 新潟薬科大学, 薬学部, 教授 2014 – 2021: 新潟薬科大学, 薬学部, 准教授 2013: 熊本大学, 生命科学研究部, 助教 2012: 熊本大学, その他の研究科, 助教 2012: 熊本大学, 大学院・生命科学研究部, 助教 … More 2011: 熊本大学, 大学院生命科学研究部, 助教 2009 – 2010: Kumamoto University, 大学院・生命科学研究部, 助教 2007 – 2008: Kumamoto University, Faculty of Medical and Pharmaceutical Sciences, Research associate 2005 – 2006: 熊本大学, 大学院医学薬学研究部, 助手 2003 – 2006: 熊本大学, 大学院・医学薬学研究部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Biological pharmacy Except Principal Investigator Biological Sciences / Biological pharmacy / Basic Section 47040:Pharmacology-related / Pain science / Physical pharmacy
Keywords	Principal Investigator アルツハイマー病 / レチノイド / ミクログリア / レチノイドX受容体 / レチノイン酸受容体 / Am80 / truncated GPNMB / GPNMB / １型ミクログリア / アルツハイマー病モデルマウス … More / 9F5抗原 / モノクローナル抗体 / HX630 / ２型ミクログリア / インターロイキン４ / 記憶改善 / アミロイドβ / インターロイキン4 / モルヒネアナローグ / インターロイキン-4 / 神経細胞 / 脳虚血 / 特異的抗体 / 酸化ストレス / 抗炎症性サイトカイン / サブタイプ / レチノイド受容体 / 神経変性疾患特異的ミクログリア / 9F5 antibody / type 1 microglia / scavenger receptor / 125I標識オリゴマー状Aβ / Truncated GPNMB / Gpnmb欠損マウス / スカベンジャー受容体 / 9F5抗体 / オリゴマー状Aβ / メラノコルチン関連ペプチド / ミクログリアサブタイプ / GFPノックインマウス / Bexarotene / 毛繕い / 強迫性障害 / 精神疾患 / 脳白質障害 / 視覚障害 / ミクログリア亜種 / 肝臓X受容体 / 記憶障害 / オリゴマー状アミロイドβ / てんかん / ノックアウトマウス / IL-12 / furin-like protease / 1型ミクログリア / 9F5 / ペプチド / βアミロイドペプチド / 2型ミクログリア / CD36 / 脳神経疾患 / レチノイド化合物 … More Except Principal Investigator CD36 / 脳虚血 / Aβクリアランス / アルツハイマー病 / 脂肪細胞 / 酸化ストレス / ミクログリア / ミクログリアサブタイプ / 単クローン抗体 / グリア細胞 / 脊髄 / DREADD / ガストリン放出ペプチド / TRPチャネル / 胆汁うっ滞 / グルココルチコイド / 表皮 / 胆汁うっ滞性そう痒 / そう痒 / 骨芽細胞 / 骨痛 / 骨転移腫瘍 / 腫瘍細胞 / miRNA / セマフォリン / 薬剤抵抗性 / がん幹細胞 / mTOR / がん性疼痛 / セマフォリン3A / al-acid elvconrotein / nrotein binding / biochemistry / 部位特異的変異法 / バリアント / 薬物相互作用 / 変異体 / 光アフィニティラベル法 / マッピング / 薬物結合部位 / α-1酸性糖タンパク質 / α_1-正酸性糖タンパク質 / α_1-酸性糖タンパク質 / タンパク結合 / 生物物理化学 / Adipocytes / Metabolic syndrome / Oxidative stress / 生活習慣病 / アディポカイン / アディポサイトカイン / メタボリックシンドローム / clearance / β-amyloid peptide / Alzheimer's disease / microglia / adipocytes / scavenger receptors / CD3b / ACAT阻害剤 / 肥満 / クリアランス / β-アミロイドペプチド / スカベンジャー受容体 / 細胞骨格 / EP4受容体 / EP3受容体 / GABA-A受容体 / 性行動 / 発熱 / アルツハイマー / 受容体サブタイプ / エンドサイトーシス / 視索前野 / フィロポディア / セクレターゼ / アミロイド / プロスタグランジン / 細胞系譜 / 病態モデルマウス / 神経細胞 / 特異的抗体 / 抗炎症性サイトカイン / サブタイプ / 神経保護作用 / ミクログリアサブタイプ Less

A strategy for Alzheimer's disease therapy by targeting neurodegenerative disease-associated one subtype of microgliaPrincipal Investigator
- Principal Investigator
  
  Kohichi Kawahara
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Elucidation of the molecular mechanisms underlying persistent pruritus in primary biliary cholangitis
- Principal Investigator
  
  Maeda Takehiko
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Niigata University of Pharmacy and Medical and Life Sciences
Development of a strategy for Alzheimer's disease therapy by agent to control function and differentiation of microglial subtypesPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Role of tumor-derived semaphorin 3A in the development of cancer pain
- Principal Investigator
  
  Maeda Takehiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Utilization of anti-inflammatory/anti-oxidative/phagocytic activities by type 2 microglia for an Alzheimer's disease therapyPrincipal Investigator
- Principal Investigator
  
  Kohichi Kawahara
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
  Kumamoto University
Selective activation of anti-inflammatory type 2 microglia as a strategy for treatment of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Development of Alzheimer's disease drug candidates promoting Aβ clearance activity of type 2 microgliaPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
プロスタノイドによる中枢シナプスネットワーク調節
- Principal Investigator
  
  杉本幸彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
  Kyoto University
Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi, 中山仁
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:細胞系譜の解析と疾患治療への応用
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Mapping of drug binding sites on al-acid glycoprotein
- Principal Investigator
  
  MARUYAMA Toru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
新たに見い出した2型ミクログリアに特徴的な神経保護作用の分子基盤の解明と応用Principal Investigator
- Principal Investigator
  
  川原浩一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:起源:分子機構解明と疾患治療への応用
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Elucidation of a novel relationship between the oxidative stress-related products and common diseases
- Principal Investigator
  
  KUNIYASU Akihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targets
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University

[Book] ビタミン・バイオファクター総合事典2021
- Author(s)
  竹谷豊、生城浩子、池田彩子、石川孝博、太田好次、小暮健太朗、瀧谷公隆、田中清、津川尚子、内藤裕二、野坂和人、福渡努、影近弘之、川原浩一ほか
- Total Pages
  672
- Publisher
  朝倉書店
- ISBN
  9784254102925
- Data Source
  KAKENHI-PROJECT-19K07004
[Book] Utilities of Anti-ligand Antibody and Mass Spectrum to Elucidate Photolabeled Sites.In: Hatanaka Y., Hashimoto M. (eds) Photoaffinity Labeling for Structural Probing Within Protein.2017
- Author(s)
  Kohichi Kawahara, Katsuyoshi Masuda, Masaji Ishiguro, Hitoshi Nakayama
- Total Pages
  265
- Publisher
  Springer
- ISBN
  9784431565680
- Data Source
  KAKENHI-PROJECT-16K08328
[Journal Article] Truncated <scp>GPNMB</scp>, a microglial transmembrane protein, serves as a scavenger receptor for oligomeric β‐amyloid peptide<sub>1‐42</sub> in primary type 1 microglia2024
- Author(s)
  Kawahara Kohichi、Hasegawa Takuya、Hasegawa Noa、Izumi Taisei、Sato Koji、Sakamaki Toshiyuki、Ando Masayuki、Maeda Takehiko
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: in press Issue: 7 Pages: 1317-1339
- DOI
  10.1111/jnc.16078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16964, KAKENHI-PROJECT-18K06707
[Journal Article] 神経変性疾患特異的１型ミクログリアとアルツハイマー病2022
- Author(s)
  川原浩一
- Journal Title
  
  細胞
  
  Volume: 54(2) Pages: 54-58
- Data Source
  KAKENHI-PROJECT-19K07004
[Journal Article] Structural requirements of cholenamide derivatives as the LXR ligands2019
- Author(s)
  Saida-Tamiya K, Tamiya M, Sekiya G, Isobe K, Kitazawa T, Isaka N, Matsukawa A, Kawahara K, Komuro A, Ishiguro M
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: in press Issue: 11 Pages: 1330-1335
- DOI
  10.1016/j.bmcl.2019.03.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08328, KAKENHI-PROJECT-19K07004
[Journal Article] ミクログリアのサブタイプとアルツハイマー病2018
- Author(s)
  川原浩一
- Journal Title
  
  細胞
  
  Volume: 50(6) Pages: 54-59
- Data Source
  KAKENHI-PROJECT-16K08328
[Journal Article] ミクログリア亜種とアルツハイマー病2017
- Author(s)
  川原浩一
- Journal Title
  
  BIO Clinica
  
  Volume: 32 Pages: 56-62
- Data Source
  KAKENHI-PROJECT-16K08328
[Journal Article] アルツハイマー治療を目指したタミバロテンの前臨床及び臨床研究2017
- Author(s)
  深澤弘志, 川原浩一, 影近弘之
- Journal Title
  
  ビタミン
  
  Volume: 91 Pages: 419-425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08328
[Journal Article] Cancer pain relief achieved by disrupting tumor-driven semaphorin 3A signaling in mice.2016
- Author(s)
  Maeda T, Yamada D, Kawahara K.
- Journal Title
  
  Neurosci Lett
  
  Volume: 632 Pages: 147-151
- DOI
  10.1016/j.neulet.2016.08.060
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08682
[Journal Article] Differentiated expression patterns and phagocytic activities of type 1 and 2 microglia2016
- Author(s)
  Akira Haga, Eri Takahashi, Yasuya Inomata, Koichi Kawahara, Hidenobu Tanihara
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460150
[Journal Article] Plexin A1 signaling confers malignant phenotypes in lung cancer cells.2016
- Author(s)
  Yamada D, Watanabe S, Kawahara K, Maeda T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 480 Issue: 1 Pages: 75-80
- DOI
  10.1016/j.bbrc.2016.10.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08682
[Journal Article] Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of rapamycin pathway2016
- Author(s)
  Yamada D, Kawahara K, Ozaki M, Maeda T
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 80 Issue: 5 Pages: 942-944
- DOI
  10.1080/09168451.2015.1136881
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08682
[Journal Article] Autocrine Semaphorin3A signaling is essential for the maintenance of stem-like cells in lung cancer.2016
- Author(s)
  Yamada D, Takahashi K, Kawahara K, Maeda T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 480 Issue: 3 Pages: 375-379
- DOI
  10.1016/j.bbrc.2016.10.057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08682
[Journal Article] The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain.2016
- Author(s)
  Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H.
- Journal Title
  
  Glia
  
  Volume: 64 Issue: 11 Pages: 1938-1961
- DOI
  10.1002/glia.23034
- NAID
  120006510950
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08682, KAKENHI-PROJECT-16K08328, KAKENHI-PROJECT-15K14983
[Journal Article] mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling.2016
- Author(s)
  Yamada D, Kawahara K, Maeda T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 476 Issue: 4 Pages: 475-480
- DOI
  10.1016/j.bbrc.2016.05.147
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08682
[Journal Article] Differentiated Expression Patterns and Phagocytic Activities of Type 1 and 2 Microglia.2016
- Author(s)
  Haga A, Takahashi E, Inomata Y, Kawahara K, Tanihara H.
- Journal Title
  
  Investigative Ophthalmology & Visual Sciences
  
  Volume: 57 Issue: 6 Pages: 2814-2823
- DOI
  10.1167/iovs.15-18509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26861457, KAKENHI-PROJECT-16K08328
[Journal Article] Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors.2015
- Author(s)
  Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1851 Issue: 4 Pages: 414-421
- DOI
  10.1016/j.bbalip.2014.07.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116003, KAKENHI-PROJECT-25460150, KAKENHI-PROJECT-26670030, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-24390017
[Journal Article] レチノイン酸受容体α/βとレチノイドX受容体の同時活性化によるアルツハイマー病の治療2015
- Author(s)
  川原浩一, 中山仁
- Journal Title
  
  MedChem News (Essay)
  
  Volume: 25 Pages: 69-74
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460150
[Journal Article] Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer’s disease.2014
- Author(s)
  Kohichi Kawahara, Michita Suenobu, Hideyuki Ohtsuka, Akihiko Kuniyasu, Yukihiko Sugimoto, Madoka Nakagomi, Hiroshi Fukasawa, Koichi Shudo, Hitoshi Nakayama
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460150
[Journal Article] Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer’s disease.2014
- Author(s)
  Kawahara K, Suenobu M, Ohtsuka H, Kuniyasu A, Sugimoto Y, Nakagomi M, Fukasawa H, Shudo K, Nakayama H
- Journal Title
  
  J Alzheimer’s Dis
  
  Volume: 42 Issue: 2 Pages: 587-605
- DOI
  10.3233/jad-132720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116003, KAKENHI-PROJECT-24390017, KAKENHI-PROJECT-25460150
[Journal Article] Tamibarotene : A candidate retinoid drug for Alzheimer's disease2012
- Author(s)
  Hiroshi Fukasawa, Madoka Nakagomi, Naoko Yamagata, Hiroshi Katsuki, Kohichi Kawahara, Kazuyoshi Kitaoka, Takami Miki, and Koichi Shudo
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 1206-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790133
[Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice2012
- Author(s)
  Kohichi Kawahara, Michita Suenobu, Akira Yoshida, Kiyohiro Koga, Atsushi Hyodo, Hideyuki Ohsuka, Akihiko Kuniyasu, Nobuaki Tamamaki, Yukihiko Sugimoto, and Hitoshi Nakayama
- Journal Title
  
  Neuroscience
  
  Volume: 207 Pages: 243-260
- NAID
  120005199489
- URL
  http://hdl.handle.net/2298/26643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790133
[Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice.2012
- Author(s)
  Kawahara K. et al.
- Journal Title
  
  Neuroscience
  
  Volume: 207 Pages: 243-260
- NAID
  120005199489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790133
[Journal Article] Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes,2011
- Author(s)
  Kuniyasu, A., Tokunaga, M., Yamamoto, T., Inoue, S., Obama, K., Kawahara, K., Nakayama, H.
- Journal Title
  
  Biochim Biophys Acta. 1811
  
  Pages: 153-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-a in rat CD40+ microglia by comparison to CD40- microglia.2009
- Author(s)
  Kawahara, K., Yoshida, A., Koga, K., Yokoo, S., Kuniyasu, A., Gotoh, T., Sawada, M., Nakayama, H.
- Journal Title
  
  J.Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-a in rat CD40+ microglia by comparison to CD40- microglia2009
- Author(s)
  Kawahara, K., Yoshida, A., Koga, K., Yokoo, S., Kuniyasu, A., Gotoh, T., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Oral administration of synthetic retinoid Am80 (tamibarotene) decreases brain β-amyloid peptides in APP23 mice.2009
- Author(s)
  Kawahara, K., et al.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1307-1309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-α in rat CD40+ microglia by comparison to CD40- microglia.2009
- Author(s)
  Kawahara, K., et al.
- Journal Title
  
  J.Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] A synthetic approach to develop peptide inhibitors delective for brain-type sodium channels on the basis of pompilidotoxin structure2009
- Author(s)
  Yokote, S., Setoguchi, R., Shimizu, E., Kawahara, K., Kuniyasu, A., Shirasaki, T., Takahama, K., Konno, K., Kawai, N., Yamaoka, K., Kinoshita, E., Nakayama H.
- Journal Title
  
  Heterocycles 79
  
  Pages: 925-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain β-amyloid peptides in APP23 mice2009
- Author(s)
  Kawahara, K., Nishi, K., Suenobu, M., Ohtsuka, H., Maeda, A., Nagatomo, K., Kuniyasu, A., Staufenbiel, M., Nakagomi, M., Shudo, K., Nakayama, H.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1307-1309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-α in rat CD40+ microglia by comparison to CD40- microglia2009
- Author(s)
  Kawahara, K.
- Journal Title
  
  J. Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] A synthetic approach to develop peptide inhibitors delective for brain-type sodium channels on the basis of pompilidotoxin structure.2009
- Author(s)
  Yokote, S., Setoguchi, R., Shimizu, E., Kawahara, K., Kuniyasu, A., Shirasaki, T., Takahama, K., Konno, K., Kawai, N., Yamaoka, K., Kinoshita, E., Nakayama H.
- Journal Title
  
  Heterocycles 79
  
  Pages: 925-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790114
[Journal Article] IL-4-induced selective clearance of oligomeric ・-amyloid peptide_<1-42> by rat type-2 microglia2008
- Author(s)
  Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Immunol 181
  
  Pages: 6503-6513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Subdomain IIIA of dog albumin contains a binding site similar to site II of human albumin2008
- Author(s)
  Kaneko, K., Fukuda, H., Chuang, V. T., Yamasaki, K., Kawahara, K., Nakayama, H., Suenaga, A., Maruyama, T., Otagiri, M.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 81-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] NO-induced apoptosis and ER stress in microglia (Review).2004
- Author(s)
  K.Kawahara, et al.
- Journal Title
  
  Folia Pharmacol.Jpn. 124
  
  Pages: 401-408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390029
[Journal Article] NO-induced apoptosis and ER stress in microglia (Review).2004
- Author(s)
  Kawahara, K. et al.
- Journal Title
  
  Folia pharmacol. Jpn. 124
  
  Pages: 401-408
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390029
[Journal Article] No-induced apoptosis and ER stress in microglia (review)2004
- Author(s)
  Kawahara, K. et al.
- Journal Title
  
  Folia Pharmacol.Jpn. 124
  
  Pages: 401-408
- Data Source
  KAKENHI-PROJECT-15390029
[Journal Article] No-induced apoptosis and ER stress in mereglia2004
- Author(s)
  Kawahara, K. et al.
- Journal Title
  
  Folia Pharmacol.Jpn. 124
  
  Pages: 401-408
- Data Source
  KAKENHI-PROJECT-16047224
[Patent] Medicament for treatment of Alzheimer's disease2016
- Inventor(s)
  K Kawahara, M Suenobu, K Shudo
- Industrial Property Rights Holder
  K Kawahara, M Suenobu, K Shudo
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Acquisition Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08328
[Patent] Medicament for treatment of Alzheimer’s disease2014
- Inventor(s)
  川原浩一, 末延道太, 首藤紘一
- Industrial Property Rights Holder
  川原浩一, 末延道太, 首藤紘一
- Industrial Property Rights Type
  特許
- Filing Date
  2014-05-30
- Overseas
- Data Source
  KAKENHI-PROJECT-25460150
[Patent] Method for Treatment of Alzheimer’s Disease2013
- Inventor(s)
  川原浩一、末延道太、首藤紘一
- Industrial Property Rights Holder
  川原浩一、末延道太、首藤紘一
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-10
- Overseas
- Data Source
  KAKENHI-PROJECT-25460150
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2011
- Inventor(s)
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Industrial Property Rights Holder
  熊本大学
- Acquisition Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23790133
[Patent] ラット１型ミクログリアを特異的に認識するモノクローナル抗体2011
- Inventor(s)
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Rights Type
  特許
- Filing Date
  2011-07-08
- Acquisition Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23790133
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Industrial Property Rights Holder
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-18053019
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体またはその断片2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2007-501565
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] 特許願2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学川原浩一中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-16047224
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体またはその断片。2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  国立大学法人熊本大学
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-17790067
[Presentation] 胆汁うっ滞性掻痒モデルのそう痒行動におけるTRPチャネルの機能的関与2022
- Author(s)
  長谷川拓也，斎須拓哉，藤原関斗，川原浩一，前田武彦
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06707
[Presentation] 9月齢5xFADマウスの記憶障害に及ぼすGpnmb遺伝子の影響2021
- Author(s)
  川原浩一、小嶋雪菜、熊倉夏希、佐野正明、細貝恒太、山田拓実、長谷川拓也、前田武彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07004
[Presentation] アルツハイマー病モデルマウスにおけるGpnmb遺伝子の機能解析2020
- Author(s)
  川原浩一、熊倉夏希、小嶋雪菜、長谷川拓也、前田武彦
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06707
[Presentation] 肺がん骨移植による悪液質モデルの作製と解析2020
- Author(s)
  長谷川拓也、山崎知槻、羽田裕介、川原浩一、前田武彦
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06707
[Presentation] アルツハイマー病モデルマウスにおけるGpnmb遺伝子の機能解析2020
- Author(s)
  川原浩一、熊倉夏希、小嶋雪菜、長谷川拓也、前田武彦
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07004
[Presentation] アルツハイマー病におけるGPNMB陽性１型ミクログリアの役割2019
- Author(s)
  川原浩一、相馬和希、長谷川拓也、前田武彦
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] 9月齢APP23マウスの空間認知障害に及ぼすGpnmb遺伝子の影響2019
- Author(s)
  倉橋諒、相馬和希、田中怜旺那、川原浩一、長谷川拓也、前田武彦
- Organizer
  N-Hybrid conference 2019
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] 新生仔ラット脳においてミクログリアはヘテロな細胞集団である2019
- Author(s)
  川原浩一、中山仁、長谷川拓也、前田武彦
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07004
[Presentation] Retinoid receptor ligand as a medicament for treatment of Alzheimer's disease2018
- Author(s)
  Kohichi Kawahara
- Organizer
  Frontier of Genomic Medicine "Retinoid (Am80, Tamibarotene) as therapeutics for intractable diseases"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] アルツハイマー病モデルマウスにおけるGPNMB陽性１型ミクログリアの役割2018
- Author(s)
  川原浩一、相馬和希、俵山悟、對馬沙耶香、長谷川拓也、前田武彦
- Organizer
  日本レチノイド研究会第29回学術集会
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] 多発性硬化症に伴う神経障害性疼痛のモデル動物の作製と薬理学的特徴付け2017
- Author(s)
  川原浩一、阿部小海、藤巻凛、笹岡直樹、長谷川万里菜、山田大祐、前田武彦
- Organizer
  第90回日本薬理学年会
- Place of Presentation
  長崎ブリックホール, 長崎
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] GPNMBの高齢発症てんかんの抑制分子としての役割2017
- Author(s)
  川原浩一、豊岡万貴、長谷川拓也、前田武彦
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] RXR agonist with Am80 improved memory deficits in a mouse model of Alzheimer's disease2016
- Author(s)
  Kohichi Kawahara, Haruna Takase, Yusuke Yamada, Daisuke Yamada, Takehiko Maeda, Hitoshi Nakayama, Hiroshi Fukasawa, Koichi Shudo
- Organizer
  SFN2016
- Place of Presentation
  San Diego Convention Center, San Diego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] がん疼痛下のモルヒネ報酬効果減弱におけるミクログリアの関与2016
- Author(s)
  前田武彦、池田崇志、丸山光、塚本敬、五十嵐悠亮、山田大祐、川原浩一
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-15K08682
[Presentation] 自己分泌型セマフォリン3aシグナルによる骨転移腫瘍の発症制御機構2016
- Author(s)
  山田大祐、川原浩一、前田武彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K08682
[Presentation] 癌性疼痛下のモルヒネ報酬効果減弱におけるミクログリアの機能的関与2016
- Author(s)
  前田武彦、山田大祐、川原浩一、池田崇志、丸山光、塚本敬、五十嵐悠亮、中沢美穂
- Organizer
  第67回日本薬理学会北部会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-15K08682
[Presentation] がん疼痛形成のセマフォリン3aによる制御機構2016
- Author(s)
  前田武彦、山田大祐、川原浩一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-15K08682
[Presentation] てんかんと１型ミクログリア2016
- Author(s)
  川原浩一、前田武彦
- Organizer
  第38回日本生物学的精神医学会/第59回日本神経化学会大会合同大会
- Place of Presentation
  福岡国際会議場, 福岡
- Data Source
  KAKENHI-PROJECT-16K08328
[Presentation] レチノイン酸受容体α/βとレチノイドX受容体の同時活性化によるアルツハイマー病の治療2015
- Author(s)
  川原浩一
- Organizer
  平成27年度日本生化学会関東支部例会/第56回新潟生化学会懇談会
- Place of Presentation
  新潟日報メディアシップ、新潟
- Year and Date
  2015-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] アルツハイマー病モデルマウスにおけるレチノイン酸受容体アゴニストAm80とレチノイドX受容体アゴニストHX630の協調的な治療効果2015
- Author(s)
  川原浩一, 末延道太, 大塚英起, 國安明彦, 杉本幸彦, 前田武彦, 中込まどか, 深澤弘志, 首藤紘一, 中山仁
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸, 神戸市
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] レチノイド化合物によるアルツハイマー病治療2015
- Author(s)
  川原浩一、前田武彦、首藤紘一、中山仁
- Organizer
  第17回応用薬理シンポジウム
- Place of Presentation
  新潟大学医学部、新潟
- Year and Date
  2015-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] Retinoid receptor ligand as a candidate drug for treatment of Alzheimer’s disease2015
- Author(s)
  Kohichi Kawahara
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  Gifu Grand Hotel, Gifu
- Year and Date
  2015-10-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] 骨がん性疼痛モデルマウスの特性とオキシコドンの効果2015
- Author(s)
  前田武彦、丸山恵奈、柳真美、山岸明、山田大祐、川原浩一
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-15K08682
[Presentation] アルツハイマー病モデルマウスにおけるレチノイン酸受容体作動薬とレチノイドX受容体作動薬の協調的な治療効果2014
- Author(s)
  川原浩一, 末延道太, 大塚英起, 國安明彦, 杉本幸彦, 中込まどか, 深澤弘志, 首藤紘一, 中山仁
- Organizer
  日本レチノイド研究会第２５回学術集会
- Place of Presentation
  秋田大学医学部, 秋田市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young APP23 mice.2013
- Author(s)
  Kohichi Kawahara, Michita Suenobu, Yukihiko Sugimoto, Hitoshi Nakayama
- Organizer
  43rd Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego convention center, San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] インターロイキン4/インターロイキン13の脳内微量注入は抗炎症性M2様ミクログリアを活性化しアルツハイマー病モデルマウスの空間認知障害を改善する2013
- Author(s)
  川原浩一, 末延道太, 吉田陽, 古賀清弘, 兵藤敦, 大塚英起, 國安明彦, 玉巻伸章, 杉本幸彦, 中山仁
- Organizer
  Neuro2013
- Place of Presentation
  京都国際会議場, 京都市
- Data Source
  KAKENHI-PROJECT-25460150
[Presentation] Oral administration of a retinoic acid receptor agonist Am80 decreases brain β-amyloid peptides in Alzheimer's disease model mice2011
- Author(s)
  Kohichi Kawahara
- Organizer
  41^<st> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington Convention Center, Washington DC, USA
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23790133
[Presentation] 新たに見出したIL-4/IL-13脳内投与によるβアミロイド分解酵素誘導の分子機序の解析2011
- Author(s)
  川原浩一
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市,京都国際会館
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23790133
[Presentation] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation and improves cognitive deficits in young APP23 mice2010
- Author(s)
  Kawahara, K., et al.
- Organizer
  29th Naito Conference on "GLIA WORLD-Dynamic Function of Glial Cells in the Brain-"
- Place of Presentation
  Shonan Village Center (Kanagawa)
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] 抗炎症性2型ミクログリアの選択的活性化によるアルツハイマー病治療法の開発2010
- Author(s)
  川原浩一
- Organizer
  武田薬品創薬研究所研究講演会
- Place of Presentation
  武田薬品工業(大阪)(招待講演)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] 抗炎症性2型ミクログリアの選択的活性化によるアルツハイマー病治療法の開発2010
- Author(s)
  川原浩一
- Organizer
  武田薬品創薬研究所研究講演会
- Place of Presentation
  武田薬品工業, 大阪(招待講演)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] レチノイン酸受容体アゴニストAm80の経口投与はアルツハイマー病モデルマウスにおける脳内βアミロイドペプチドを減少させる2010
- Author(s)
  川原浩一
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートピアホテル(神戸)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β -amyloid accumulation and improves cognitive deficits in young APP23 mice2010
- Author(s)
  Kawahara, K.
- Organizer
  29th Naito Conference on " GLIA WORLD- Dynamic Function of Glial Cells in the Brain -"
- Place of Presentation
  Shonan Village Center, Kanagawa
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] レチノイン酸受容体アゴニストAm80 の経口投与はアルツハイマー病モデルマウスにおける脳内βアミロイドペプチドを減少させる2010
- Author(s)
  川原浩一
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場, 神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] インターロイキン4で活性化したラット初代培養2型ミクログリアによるオリゴマー状アミロイドβペプチド_<1-42>の選択的クリアランス2009
- Author(s)
  川原浩一, ら
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド、神戸市
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] IL-4/IL-13で誘導されるAβクリアランス能 : アルツハイマー病モデルAPP23マウスでの評価2009
- Author(s)
  川原浩一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Interleukin-4-induced selective clearance of oligomeric β-amyloid peptied_<1-42> by rat primary type 2 microglia2009
- Author(s)
  Kawahara, K., et al.
- Organizer
  39th Annual Meeting of Society for Neuroscience
- Place of Presentation
  McCormic Place, Chicago, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] Interleukin-4-induced selective clearance of oligomeric β-amyloid peptide_1-42 by rat primary type 2 microglia2009
- Author(s)
  Kawahara, K.
- Organizer
  39th Annual Meeting of Society for Neuroscience
- Place of Presentation
  McCormick Place convention center, Chicago, US
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] インターロイキン4で活性化したラット初代培養2型ミクログリアによるオリゴマー状アミロイドβペプチド1-42の選択的クリアランス2009
- Author(s)
  川原浩一
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場, 神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790114
[Presentation] LPS/IFN γ 海馬内投与ラツトにおいてiNOSタンパク質はKM9F5陽性ミクロクリアに発現する2008
- Author(s)
  川原浩一
- Organizer
  第81回日本生化学会大会第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療の可能性.2008
- Author(s)
  川原浩一
- Organizer
  日本レチノイド研究会第19回学術集会
- Place of Presentation
  東京
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療の可能性2008
- Author(s)
  川原浩一
- Organizer
  日本レチノイド研究会第19回学術集会
- Place of Presentation
  東京
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] LPS/IFNγ海馬内投与ラットにおいてiNOSタンパク質はKM9F5陽性ミクログリアに発現する2008
- Author(s)
  川原浩一
- Organizer
  第81回日本生化学会大会第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Different induction of iNOS and TNFα by LPS in two subtypes of rat microglia.2007
- Author(s)
  川原浩一
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Different induction of iNOS and TNF-alpha by LPS in two subtypes of rat microglia2007
- Author(s)
  川原浩一
- Organizer
  第80回日本生化学会大会第30回日本分子生物学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Different induction of iNOS and TNFα by LPS in two subtypes of rat microglia.2007
- Author(s)
  川原浩一
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18053019
[Presentation] Oral administration of a retinoic acid receptor agonist Am80 decreases brain β-amyloid peptides in Alzheimer’s disease model mice
- Author(s)
  Kawahara K et al
- Organizer
  41st Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, Washington Convention Center,USA
- Data Source
  KAKENHI-PROJECT-23790133
[Presentation] レチノイン酸受容体アゴニストAm80とレチノイドX受容体HX630の併用投与はアルツハイマー病モデルAPP23マウスの不溶性アミロイドβペプチドを減少させ記憶障害を改善する
- Author(s)
  川原浩一
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子市, 米子コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23790133
[Presentation] 新たに見出したIL-4/IL-13脳内投与によるβアミロイド分解酵素誘導の分子機序の解析
- Author(s)
  川原浩一ら
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市, 京都国際会館
- Data Source
  KAKENHI-PROJECT-23790133

1. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. Maeda Takehiko (50271010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
4. NAKAJIMA Makoto (50207792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MARUYAMA Toru (90423657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 杉本幸彦 (80243038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 瀬木恵里 (70378628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山田大祐 (50733680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. 長谷川拓也 (80813287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. KAWAHARA Atsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 高橋枝里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 谷原秀信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAHARA Kohichi 川原 浩一

川原 浩一 カワハラ コウイチ

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A strategy for Alzheimer's disease therapy by targeting neurodegenerative disease-associated one subtype of microgliaPrincipal Investigator

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Development of a strategy for Alzheimer's disease therapy by agent to control function and differentiation of microglial subtypesPrincipal Investigator

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Utilization of anti-inflammatory/anti-oxidative/phagocytic activities by type 2 microglia for an Alzheimer's disease therapyPrincipal Investigator

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Selective activation of anti-inflammatory type 2 microglia as a strategy for treatment of Alzheimer's diseasePrincipal Investigator

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Development of Alzheimer's disease drug candidates promoting Aβ clearance activity of type 2 microgliaPrincipal Investigator

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Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator

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新たに見い出した2型ミクログリアに特徴的な神経保護作用の分子基盤の解明と応用Principal Investigator

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KAWAHARA Kohichi 川原浩一

川原浩一カワハラコウイチ