Shimizu Soichiro 清水聰一郎

Researcher Number	10385031
Affiliation (Current)	2022: 東京医科大学, 医学部, 主任教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 東京医科大学, 医学部, 主任教授 2019: 東京医科大学, 医学部, 准教授 2014 – 2018: 東京医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator General internal medicine(including psychosomatic medicine) / Basic Section 52010:General internal medicine-related Except Principal Investigator General internal medicine(including psychosomatic medicine) / Neurology / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 認知症 / アルツハイマー病 / フレイル / レビー小体病 / 運動 / サルコペニア / 運動介入 / リハビリ / 高齢者 / 認知機能 … More / 医療・福祉 / 老化 / 睡眠障害 / オレキシン … More Except Principal Investigator 認知症 / 糖尿病 / 14-3-3蛋白 / HMGB1 / Beclin1 / オートファジ－ / アルツハイマ－病 / ＴＤＰ-43 / オ－トファジ－ / Beclin-1 / 頸動脈プラ－ク / アルツハイマー病 / 高齢者総合機能評価 / 生活機能障害 / 生活支援 / 高齢者 / 内科 / 神経細胞死 / １４－３－３蛋白 / ＨＭＧＢ1 / Ｂｅｃｌｉｎ1 / 脳梗塞 / レビ－小体型認知症 / 血栓 / 頸動脈 / リン酸化TDP43 / 筋萎縮性側索硬化症 / Beclin 1 / アミロイド / タウ / PET / 脳脊髄液 / 介護者教育 / 介護負担感 / 介護うつ / BPSD / 認知症介護者 / MCI / WMH / DWMH / PVH / 白質病変容積 / 大脳白質病変 / 抑うつ / 前頭前野背外側 / 軽度認知障害 / 大脳白質病変容積 / 血清シスタチンＣ / シスタチンＣ / シスタチンC / 軽度認知機能障害 / 認知機能 / 脳血流 / 血管性認知症 / 脳血管障害 / 頚動脈プラ-ク / リン酸化TDP-43 / Rubicon / beclin1 / BRCA1 / 脳動脈硬化 / オートファーゴソーム / TDP-43 / 14-3-3タンパク / マクロファ-ジ / 動脈硬化 / 内頚動脈プラ-ク / 分子制御された細胞死 / 分子制御細胞死 / レビー小体型認知症 / 脳血流SPECT / Cingulate Island Sign / IMP-SPECT / Alzheimer / DLB / Lewy / 糖尿病性認知症 / cingulate island sign / Alzheimer病 / Sarcopenia / フレイル Less

Approach from sleep disturbance treatment in dementia treatment-The Importance of orexinergic system-Principal Investigator
- Principal Investigator
  
  清水聰一郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical University
Comprehensive study of "molecular-controlled cell death and autophagy" in dementia and cerebrovascular disease in the elderly
- Principal Investigator
  
  TAKAHIKO UMAHARA
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical University
Exploratory research on treatments for Diabetes-related dementia
- Principal Investigator
  
  KANETAKA HIDEKAZU
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical University
Effects of caregivers' education on depression symptoms and sense of burden of dementia patient caregivers
- Principal Investigator
  
  Sakurai Hirofumi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
The effect of white matter hyperintensity volume on cognition, depressive symptoms, and regional cerebral blood flow in mild cognitive impairment
- Principal Investigator
  
  Hirao Kentaro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
Prevention for aging by exercise intervention for oldPrincipal Investigator
- Principal Investigator
  
  Shimizu Soichiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
Pathophysiological study of diabetes-related dementia
- Principal Investigator
  
  Hanyu Haruo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University
Living support for regional elderly using comprehensive geriatric assessment
- Principal Investigator
  
  Sakurai Hirofumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1
- Principal Investigator
  
  Umahara Takahiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment2021
- Author(s)
  Kentaro Hirao, Fumio Yamashita, Shu Sakurai, Akito Tsugawa, Rieko Haime, Raita Fukasawa, Tomohiko Sato, Hidekazu Kanetaka, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu, Soichiro Shimizu
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 21 Pages: 644-650
- DOI
  10.1111/ggi.14211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09327
[Journal Article] Effects of 12‐month exercise intervention on physical and cognitive functions of nursing home residents requiring long‐term care: a non‐randomised pilot study2020
- Author(s)
  Tsugawa Akito、Shimizu Soichiro、Hirose Daisuke、Sato Tomohiko、Hatanaka Hirokuni、Takenoshita Naoto、Kaneko Yoshitsugu、Ogawa Yusuke、Sakurai Hirofumi、Hanyu Haruo
- Journal Title
  
  Psychogeriatrics
  
  Volume: -
- DOI
  10.1111/psyg.12517
- Data Source
  KAKENHI-PROJECT-16K09260
[Journal Article] Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries2020
- Author(s)
  Umahara T, Uchihara T, Hirao K, Shimizu S, Hashimoto T, Akimoto J, Kohno M, Hanyu H.
- Journal Title
  
  Histol Histopathol
  
  Volume: 35 Pages: 159-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426
[Journal Article] Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.2020
- Author(s)
  Umahara T, Uchihara T, Hirao K, Shimizu S, Hanyu H.
- Journal Title
  
  Histology and Histopathology
  
  Volume: 35 Pages: 1023-1028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426
[Journal Article] Association between cerebrospinal fluid Orexin A level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies2020
- Author(s)
  Inagawa Yuta、Shimizu Soichiro、Takenoshita Naoto、Tsugawa Akito、Hirose Daisuke、Kanbayashi Takashi、Imanishi Aya、Sakurai Hirofumi、Hanyu Haruo、Kanetaka Hidekazu、Hirao Kentaro
- Journal Title
  
  Psychogeriatrics
  
  Volume: 21 Pages: 128-130
- DOI
  10.1111/psyg.12618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08037, KAKENHI-PROJECT-20K07811
[Journal Article] Essential autophagic protein Beclin 1 localizes to atherosclerotic lesions of human carotid and major intracranial arteries.2020
- Author(s)
  Umahara Takahiko、Uchihara Toshiki、Hirao Kentaro、Shimizu Soichiro、Hashimoto Takao、Kohno Michihiro、Hanyu Haruo
- Journal Title
  
  J Neurol Sci
  
  Volume: 414 Pages: 116836-116836
- DOI
  10.1016/j.jns.2020.116836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426, KAKENHI-PROJECT-17H03555
[Journal Article] Positive Association Between Cognitive Function and Cerebrospinal Fluid Orexin A Levels in Alzheimer's Disease2020
- Author(s)
  Shimizu Soichiro、Takenoshita Naoto、Inagawa Yuta、Tsugawa Akito、Hirose Daisuke、Kaneko Yoshitsugu、Ogawa Yusuke、Serisawa Shuntaro、Sakurai Shu、Hirao Kentaro、Kanetaka Hidekazu、Kanbayashi Takashi、Imanishi Aya、Sakurai Hirofumi、Hanyu Haruo
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 73 Pages: 117-123
- DOI
  10.3233/jad-190958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08037, KAKENHI-PROJECT-20K07811
[Journal Article] Classification of Clinically Diagnosed Alzheimer’s Disease Associated with Diabetes Based on Amyloid and Tau PET Results2019
- Author(s)
  Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 71 Pages: 261-271
- DOI
  10.3233/jad-190620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07479, KAKENHI-PROJECT-19K07898, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K09813
[Journal Article] Neuroimaging Characteristics of Frailty Status in Patients with Alzheimer's Disease.2019
- Author(s)
  Hirose D, Shimizu S, Hirao K, Ogawa Y, Sato T, Kaneko Y, Takenoshita N, Namioka N, Fukasawa R, Umahara T, Sakurai H, Watanabe R, Hanyu H.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 67 Pages: 1201-1208
- DOI
  10.3233/jad-180701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09260
[Journal Article] Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease.2018
- Author(s)
  Ogawa Y, Kaneko Y, Sato T, Shimizu S, Kanetaka H, Hanyu H
- Journal Title
  
  Front Neurol.
  
  Volume: 9 Pages: 7-10
- DOI
  10.3389/fneur.2018.00710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07479
[Journal Article] Cerebrospinal fluid analysis in individuals with diabetes-related dementia.2017
- Author(s)
  Kanetaka H, Fukasawa R, Shimizu S, Takenoshita N, Hanyu H
- Journal Title
  
  eNeurological Sci
  
  Volume: 8 Pages: 9-10
- DOI
  10.1016/j.ensci.2017.06.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09362
[Journal Article] Peripheral oxidative stress markers in diabetes-related dementia.2016
- Author(s)
  Hatanaka H, Hanyu H, Fukasawa R, Sato T, Shimizu S, Sakurai H.
- Journal Title
  
  Geriatrics Gerontology International
  
  Volume: 16 Pages: 1312-1318
- DOI
  10.1111/ggi.12645
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09362
[Journal Article] Identification of diabetes-relatde dementia:Longitudinal perfuison SPECT and amyloid PET studies.2015
- Author(s)
  Fukasawa R, Hanyu H, Shimizu S, Kanetaka H, sakurai H, Ishi K
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 349 Pages: 45-51
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09362
[Presentation] レビー小体型認知症のCingulate Island Signと関連する臨床症候2021
- Author(s)
  金高秀和、芹澤俊太郎、竹野下尚仁、小川裕介、深澤雷太、高田祐輔、佐藤友彦、平尾健太郎、清水聰一郎
- Organizer
  日本老年病学会
- Data Source
  KAKENHI-PROJECT-18K07479
[Presentation] Cingulate Island Signを示すDLBの特徴2021
- Author(s)
  金高秀和、稲川雄太、櫻井　周芹澤俊太郎、金子　義嗣、小川裕介、竹野下尚仁、佐藤友彦、平尾健太郎、清水聰一郎
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07479
[Presentation] 軽度認知障害における局所大脳白質病変容積と認知機能との関連2020
- Author(s)
  櫻井周,平尾健太郎,山下典生,都河明人,ハイメ理恵子,深澤雷太,佐藤友彦,金高秀和,馬原孝彦,櫻井博文,羽生春夫,清水聰一郎
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K09327
[Presentation] SEEを用いたIMP-脳血流SPECTのCingulate Island Sign2019
- Author(s)
  金高秀和、清水聰一郎、竹野下尚仁、小川裕介、深澤雷太、高田祐輔、佐藤友彦、平尾健太郎、櫻井博文、羽生春夫
- Organizer
  日本老年医学会
- Data Source
  KAKENHI-PROJECT-18K07479
[Presentation] IMP-脳血流SPECTにおけるCingulate Island Signの適正VOI検討2019
- Author(s)
  金高秀和、稲川雄太、芹澤俊太郎、竹野下尚仁、深澤雷太、佐藤友彦、平尾健太郎、清水聰一郎、櫻井博文、羽生春夫
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07479
[Presentation] Differentiating mild cognitive impairment, Alzheimer’s disease, and dementia with Lewy bodies using Cingulate island sign and perfusion IMP-SPECT2019
- Author(s)
  Hidekazu Kanetaka, Naoto Takenoshita, Daisuke Hirose, Soichiro Shimizu, Hirofumi Sakurai, Haruo Hanyu
- Organizer
  The International Association of Gerontology and Geriatrics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07479
[Presentation] 高齢者脳動脈および脳実質病変でのHMGB1の発現様式2016
- Author(s)
  馬原孝彦　廣瀬大輔　深沢雷太　清水聰一郎　山川仁子　平尾健太郎　金高秀和　櫻井博文　羽生春夫内原俊記
- Organizer
  第58回日本老年医学会学会学術集会
- Place of Presentation
  石川県金沢市
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] Localizaｔon of Beclin-1 in　human main cerebral and　caroed arteries2016
- Author(s)
  Takahiko Umahara, Shoichiro Shimizu, Kentaro Hirao, Haruo Hanyu, Toshiki Uchihara
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461282

1. Hanyu Haruo (10228520)

# of Collaborated Projects: 8 results

# of Collaborated Products: 17 results
2. Sakurai Hirofumi (60235223)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
3. KANETAKA HIDEKAZU (90385021)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
4. Hirao Kentaro (40516639)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
5. Umahara Takahiko (70266477)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
6. 秋元治朗 (10212440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 橋本孝朗 (60266517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 佐藤友彦 (70421071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 土田明彦 (50207396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮澤啓介 (50209897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 赫寛雄 (70307338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 織田順 (60459500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石井賢二 (10231135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 松岡正明 (70222297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 上野竜一 (20384951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 今林悦子 (30406491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 長田卓也 (60297281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松田博史 (90173848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 深澤雷太 (30795646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 山下典生 (90628455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 河野道宏 (50718707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高田祐輔 (20449193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 神林崇 (50323150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. SUZUKI Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Soichiro 清水 聰一郎

Research Projects

Research Products

Co-Researchers

Approach from sleep disturbance treatment in dementia treatment-The Importance of orexinergic system-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive study of "molecular-controlled cell death and autophagy" in dementia and cerebrovascular disease in the elderly

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research on treatments for Diabetes-related dementia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of caregivers' education on depression symptoms and sense of burden of dementia patient caregivers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of white matter hyperintensity volume on cognition, depressive symptoms, and regional cerebral blood flow in mild cognitive impairment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention for aging by exercise intervention for oldPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiological study of diabetes-related dementia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Living support for regional elderly using comprehensive geriatric assessment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of 12‐month exercise intervention on physical and cognitive functions of nursing home residents requiring long‐term care: a non‐randomised pilot study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries2020

Author(s)

Journal Title

Data Source

[Journal Article] Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.2020

Author(s)

Journal Title

Data Source

[Journal Article] Association between cerebrospinal fluid Orexin A level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies2020

Author(s)

Journal Title

DOI

Shimizu Soichiro 清水聰一郎