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Umahara Takahiko  馬原 孝彦

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UMAHARA Takahiko  馬原 孝彦

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Researcher Number 70266477
Affiliation (Current) 2022: 東京医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2018 – 2020: 東京医科大学, 医学部, 客員教授
2011 – 2017: 東京医科大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Neurology / Basic Section 52010:General internal medicine-related
Except Principal Investigator
General internal medicine(including psychosomatic medicine) / General pharmacology / Basic Section 52010:General internal medicine-related
Keywords
Principal Investigator
14-3-3蛋白 / HMGB1 / Beclin1 / TDP-43 / オ-トファジ- / Beclin-1 / 頸動脈プラ-ク / 神経細胞死 / 14-3-3蛋白 / HMGB1 … More / Beclin1 / 脳梗塞 / レビ-小体型認知症 / 血栓 / 頸動脈 / リン酸化TDP43 / オートファジ- / 筋萎縮性側索硬化症 / Beclin 1 / アルツハイマ-病 / オートファーゴソーム / 頚動脈プラ-ク / 脳動脈硬化 / TDP-43 / 14-3-3タンパク / リン酸化TDP-43 / マクロファ-ジ / 動脈硬化 / 内頚動脈プラ-ク / 分子制御された細胞死 / 脳血管障害 / 認知症 / 分子制御細胞死 … More
Except Principal Investigator
アルツハイマー病 / 神経細胞死 / ヒューマニン / 介護者教育 / 介護負担感 / 介護うつ / 認知症 / BPSD / 認知症介護者 / 軽度認知障害 / 大脳白質病変 / WMH / PVH / DWMH / 大脳白質病変容積 / 血清シスタチンC / シスタチンC / MCI / シスタチンC / 軽度認知機能障害 / 認知機能 / 抑うつ / 脳血流 / 糖尿病性認知症 / cingulate island sign / レビー小体型認知症 / IMP-SPECT / Alzheimer病 / Cingulate Island Sign / Sarcopenia / 糖尿病 / フレイル Less
  • Research Projects

    (6 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (18 People)
  •  高齢者の認知症・脳血管障害での「分子制御された細胞死・オ-トファジ-」包括研究Principal Investigator

    • Principal Investigator
      馬原 孝彦
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Tokyo Medical University
  •  糖尿病性認知症の治療法探索研究

    • Principal Investigator
      金高 秀和
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Tokyo Medical University
  •  認知症介護者の介護負担感と介護うつに対する介護者教育の効果に関する研究

    • Principal Investigator
      櫻井 博文
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Tokyo Medical University
  •  軽度認知機能障害における大脳白質病変容積の認知機能、抑うつ、脳血流に対する影響

    • Principal Investigator
      平尾 健太郎
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Tokyo Medical University
  •  Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1Principal Investigator

    • Principal Investigator
      Umahara Takahiko
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical University
  •  Characterization and clinical application of endogenous Alzheimer's disease-suppressing factor

    • Principal Investigator
      MATSUOKA Masaaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tokyo Medical University

All 2020 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries2020

    • Author(s)
      Umahara T, Uchihara T, Hirao K, Shimizu S, Hashimoto T, Akimoto J, Kohno M, Hanyu H.
    • Journal Title

      Histol Histopathol

      Volume: 35 Pages: 159-167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07426
  • [Journal Article] Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.2020

    • Author(s)
      Umahara T, Uchihara T, Hirao K, Shimizu S, Hanyu H.
    • Journal Title

      Histology and Histopathology

      Volume: 35 Pages: 1023-1028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07426
  • [Journal Article] Essential autophagic protein Beclin 1 localizes to atherosclerotic lesions of human carotid and major intracranial arteries.2020

    • Author(s)
      Umahara Takahiko、Uchihara Toshiki、Hirao Kentaro、Shimizu Soichiro、Hashimoto Takao、Kohno Michihiro、Hanyu Haruo
    • Journal Title

      J Neurol Sci

      Volume: 414 Pages: 116836-116836

    • DOI

      10.1016/j.jns.2020.116836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07426, KAKENHI-PROJECT-17H03555
  • [Journal Article] 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease2018

    • Author(s)
      Wakabayashi Kaori、Umahara Takahiko、Hirokawa Katsuiku、Hanyu Haruo、Uchihara Toshiki
    • Journal Title

      Neuroscience Letters

      Volume: 674 Pages: 171-175

    • DOI

      10.1016/j.neulet.2018.03.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K14572, KAKENHI-PROJECT-26461282, KAKENHI-PROJECT-17H03555
  • [Journal Article] 14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis2016

    • Author(s)
      Umahara T, Uchihara T, Shibata N, Nakamura A, Hanyu H
    • Journal Title

      Brain Reserch

      Volume: 1646 Pages: 132-132

    • DOI

      10.1016/j.brainres.2016.05.051

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430057, KAKENHI-PROJECT-25670427, KAKENHI-PROJECT-26461282, KAKENHI-PROJECT-16K14572
  • [Presentation] 軽度認知障害における局所大脳白質病変容積と認知機能との関連2020

    • Author(s)
      櫻井周,平尾健太郎,山下典生,都河明人,ハイメ理恵子,深澤雷太,佐藤友彦,金高秀和,馬原孝彦,櫻井博文,羽生春夫,清水聰一郎
    • Organizer
      日本認知症学会
    • Data Source
      KAKENHI-PROJECT-17K09327
  • [Presentation] 脳梗塞剖検脳における急性期および慢性期でのHMGB1局在の差異2017

    • Author(s)
      馬原孝彦、山川仁子、櫻井博文、羽生春夫
    • Organizer
      第51回日本成人病(生活習慣病)学会学術集会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2017-01-14
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 14-3-3 sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites of the patients with Lewy body disease2017

    • Author(s)
      Umahara T, Wakabayashi K Hirokawa K, Hanyu H , Uchihara T
    • Organizer
      XXIII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 免疫組織化学から認知症治療開発へ向けての情報提示2017

    • Author(s)
      馬原孝彦
    • Organizer
      日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 高齢者脳動脈および脳実質病変でのHMGB1の発現様式2016

    • Author(s)
      馬原孝彦 廣瀬大輔 深沢雷太 清水聰一郎 山川仁子 平尾健太郎 金高秀和 櫻井博文 羽生春夫 内原俊記
    • Organizer
      第58回日本老年医学会学会学術集会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2016-06-08
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] Localizaton of Beclin-1 in human main cerebral and caroed arteries2016

    • Author(s)
      Takahiko Umahara, Shoichiro Shimizu, Kentaro Hirao, Haruo Hanyu, Toshiki Uchihara
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] Immunohistochemical Examination of Human Mural Thrombus Associated with Carotid Plaques2016

    • Author(s)
      Takahiko Umahara, Haruo Hanyu, Toshiki Uchihara
    • Organizer
      the 9th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-10-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 脳細動脈におけるマクロファ-ジとHMGB 1蛋白の局在2016

    • Author(s)
      馬原 孝彦
    • Organizer
      第50回日本成人病(生活習慣病)学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2016-01-17
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 急性期脳梗塞剖検脳でのHMGB 1の発現様式-抗体治療の基礎的研究として-2016

    • Author(s)
      馬原 孝彦
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] オ-トファジ-関連物質Beclin 1の頸動脈硬化病変での発現-第二報-2015

    • Author(s)
      馬原 孝彦
    • Organizer
      第57回日本老年医学会学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2015-06-14
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] Immunolocalization of 14-3-3 proteins in atheroslerotic lesions of human carotid and main cerebral arteries2015

    • Author(s)
      馬原 孝彦
    • Organizer
      International Association of Gerontology and Geriatrics Asia/Oceania 2015 Congress
    • Place of Presentation
      チェンマイ タイ
    • Year and Date
      2015-10-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 主幹脳動脈および頸動脈病変でのHMGB1蛋白の局在意義-続報-2015

    • Author(s)
      馬原 孝彦
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-05-15
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] ダメ-ジ関連分子パタ-ンHMGB 1蛋白の局在様式-脳卒中治療応用への基礎的検討-

    • Author(s)
      馬原 孝彦
    • Organizer
      日本脳卒中学会総会
    • Place of Presentation
      広島県広島市 リーガロイヤルホテル広島
    • Year and Date
      2015-03-26 – 2015-03-27
    • Data Source
      KAKENHI-PROJECT-26461282
  • [Presentation] 障害関連分子HMGB1の分布-「炎症と認知機能障害」の基礎的検討として-

    • Author(s)
      馬原 孝彦
    • Organizer
      日本認知症学会総会学術集会
    • Place of Presentation
      神奈川県横浜市 パシフィコ横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461282
  • 1.  羽生 春夫 (10228520)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 11 results
  • 2.  清水 聰一郎 (10385031)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 6 results
  • 3.  平尾 健太郎 (40516639)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 4.  櫻井 博文 (60235223)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  金高 秀和 (90385021)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  秋元 治朗 (10212440)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  橋本 孝朗 (60266517)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  佐藤 友彦 (70421071)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 9.  MATSUOKA Masaaki (70222297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  IWAMOTO Toshihiko (10246168)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  宮澤 啓介 (50209897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  赫 寛雄 (70307338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  織田 順 (60459500)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  深澤 雷太 (30795646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  山下 典生 (90628455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  河野 道宏 (50718707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  高田 祐輔 (20449193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  内原 俊記
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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