Hayashi Shusaku 林周作

… Alternative Names

HAYASHI SHUUSAKU 林周作

HAYASHI Shusaku 林周作

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Researcher Number	10548217
Other IDs	https://orcid.org/0000-0002-8304-7255
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 京都薬科大学, 薬学部, 准教授 2023: 京都薬科大学, 薬学部, 准教授 2019 – 2022: 富山大学, 学術研究部薬学・和漢系, 助教 2015 – 2018: 富山大学, 和漢医薬学総合研究所, 助教 2012 – 2013: 富山大学, 和漢医薬学総合研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / General internal medicine (including Psychosomatic medicine) Except Principal Investigator General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator 炎症性腸疾患 / 腸管マクロファージ / 粘膜治癒 / 粘膜バリア / ゆらぎ / 再燃予防 / IBD / 腸管上皮細胞 / オルガノイド / 大腸上皮細胞 … More / IL-10 / DNB / 創傷治癒 / 粘膜免疫 / 遷移点 / ヒトIBD / Wars / 未病 / 動的ネットワークバイオマーカー / 腸管粘膜免疫系 / 粘膜修復 / ベルベリン / 長期寛解維持 / DARTS / IBD再燃モデル / 上皮細胞 / Fatty acid synthase / 上皮・免疫連関 / 腸管粘膜バリア / 大腸上皮オルガノイド / CMKLR1 / 腸管上皮 / 腸管粘膜修復 / CD11c陽性細胞 / 大腸オルガノイド / GPCR / BLT1 / 遊走 / CD206 / マクロファージ / 腸管粘膜免疫 / 大腸炎関連発がん / 潰瘍性大腸炎 … More Except Principal Investigator 漢方薬 / 東洋医学 / 標的タンパク質 / リポジショニング / 和漢医薬学 / 実験薬理学的検証 / 標的タンパク質探索 / 結合シミュレーション / 機械学習手法 / インシリコ / in silico結合シミュレーション / 機械学習 / 医薬ビッグデータ / 複雑系 / ドラッグ・リポジショニング / プエラリン / 腸管粘膜免疫 / 制御性T細胞 / 腸管粘膜免疫系 / 葛根湯 / 食物アレルギー Less

Pathophysiological significance of Wars, a Me-byo gene, in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  林周作
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto Pharmaceutical University
Creation of New Therapeutic Strategy for Inflammatory Bowel Disease Aiming to Prevent Relapse Based on Rebuilding Mucosal BarrierPrincipal Investigator
- Principal Investigator
  
  Hayashi Shusaku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto Pharmaceutical University
  University of Toyama
A Research of Epithelium-Immune Interaction during Mucosal Repair in Inflammatory Bowel DiseasePrincipal Investigator
- Principal Investigator
  
  Hayashi Shusaku
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  University of Toyama
Development of Novel Therapeutic Medicines for Inflammatory Bowel Disease with Enhancement of IL-10 Production in Intestinal MacrophagesPrincipal Investigator
- Principal Investigator
  
  Hayashi Shusaku
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  University of Toyama
Mode-of-action analysis of Kampo formulae and prediction of their new indications for a wide range of diseases
- Principal Investigator
  
  Kadowaki Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
Role of CD206 Positive Macrophages in the Intestinal Homeostasis and Inflammatory Bowel DiseasePrincipal Investigator
- Principal Investigator
  
  Hayashi Shusaku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  University of Toyama
Anti-allergic effect of kakkonto by regulating intestinal mucosal immunity through the induction of regulatory T cells in the colon
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
Search for Therapeutic Drugs Against Ulcerative Colitis-Mechanism Elucidation of DaikenchutoPrincipal Investigator
- Principal Investigator
  
  HAYASHI Shusaku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Allergic inflammation disrupts epithelial electrogenic electrolyte transport through cholinergic regulation in the mouse colon2023
- Author(s)
  Yamamoto Takeshi, Katsuki Yosuke, Kanauchi Yuya, Hayashi Shusaku, Kadowaki Makoto
- Journal Title
  
  Biomed. Res.
  
  Volume: 44 Issue: 1 Pages: 31-40
- DOI
  10.2220/biomedres.44.31
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2023-01-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07908, KAKENHI-PROJECT-17KK0166, KAKENHI-PROJECT-21K06593
[Journal Article] Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells2022
- Author(s)
  Kanauchi Yuya、Yamamoto Takeshi、Yoshida Minako、Zhang Yue、Lee Jaemin、Hayashi Shusaku、Kadowaki Makoto
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 54-54
- DOI
  10.1038/s41598-021-04154-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-19K07908, KAKENHI-PROJECT-20K07098, KAKENHI-PROJECT-21K06593
[Journal Article] Intestinal epithelial BLT1 promotes mucosal repair2022
- Author(s)
  Hayashi Shusaku、Muraleedharan Chithra K.、Oku Makito、Tomar Sunil、Hogan Simon P.、Quiros Miguel、Parkos Charles A.、Nusrat Asma
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 23
- DOI
  10.1172/jci.insight.162392
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0166, KAKENHI-PROJECT-21K06593
[Journal Article] Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice2021
- Author(s)
  Yashiro Tomoe、Ogata Hanako、Zaidi Syed Faisal、Lee Jaemin、Hayashi Shusaku、Yamamoto Takeshi、Kadowaki Makoto
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 7 Pages: 1586-1586
- DOI
  10.3390/cells10071586
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-19K07908, KAKENHI-PROJECT-20K07098
[Journal Article] Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan2020
- Author(s)
  Koizumi Keiichi、Oku Makito、Hayashi Shusaku、Inujima Akiko、Shibahara Naotoshi、Chen Luonan、Igarashi Yoshiko、Tobe Kazuyuki、Saito Shigeru、Kadowaki Makoto、Aihara Kazuyuki
- Journal Title
  
  Evidence-Based Complementary and Alternative Medicine
  
  Volume: 2020 Issue: 1 Pages: 1-9
- DOI
  10.1155/2020/9129134
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-15H05707
[Journal Article] Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function2020
- Author(s)
  Hertati Ai、Hayashi Shusaku、Ogawa Yudai、Yamamoto Takeshi、Kadowaki Makoto
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11 Pages: 573470-573470
- DOI
  10.3389/fphar.2020.573470
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-20K07098, KAKENHI-PROJECT-17KK0166
[Journal Article] Morphological elucidation of short-chain fatty acid receptor GPR41-positive enteric sensory neurons in the colon of mice with dextran sulfate sodium-induced colitis2020
- Author(s)
  Hertati Ai、Hayashi Shusaku、Ogata Hanako、Miyata Kana、Kato Ryo、Yamamoto Takeshi、Kadowaki Makoto
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 12 Pages: e05647-e05647
- DOI
  10.1016/j.heliyon.2020.e05647
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-20K07098, KAKENHI-PROJECT-17KK0166
[Journal Article] Unraveling the Pathogenesis of Inflammatory Bowel Disease and Search for New Therapeutic Medicines2020
- Author(s)
  Hayashi Shusaku
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 2 Pages: 123-128
- DOI
  10.1248/yakushi.19-00164
- NAID
  130007793320
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06698
[Journal Article] Isoflavones Suppress Cyp26b1 Expression in the Murine Colonic Lamina Propria2020
- Author(s)
  Yamamoto Takeshi、Nagata Yuka、Hayashi Shusaku、Kadowaki Makoto
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 12 Pages: 1945-1949
- DOI
  10.1248/bpb.b20-00355
- NAID
  130007948731
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-19K07908, KAKENHI-PROJECT-20K07098
[Journal Article] Therapeutic Benefit in Allergic Dermatitis Derived from the Inhibitory Effect of Byakkokaninjinto on the Migration of Plasmacytoid Dendritic Cells2020
- Author(s)
  Yamamoto Takeshi、Zhang Yue、Kigasawa Ai、Hayashi Shusaku、Kadowaki Makoto
- Journal Title
  
  Evidence-Based Complementary and Alternative Medicine
  
  Volume: 2020 Issue: 1 Pages: 1-10
- DOI
  10.1155/2020/9532475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06698, KAKENHI-PROJECT-19K07908, KAKENHI-PROJECT-20K07098
[Journal Article] KampoDB, database of predicted targets and functional annotations of natural medicines.2018
- Author(s)
  Sawada R, Iwata M, Umezaki M, Usui Y, Kobayashi T, Kubono T, Hayashi S, Kadowaki M, Yamanishi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 11216-11216
- DOI
  10.1038/s41598-018-29516-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05276
[Journal Article] Improvement of Therapeutic Efficacy of Oral Immunotherapy in Combination with Regulatory T Cell-Inducer Kakkonto in a Murine Food Allergy Model.2017
- Author(s)
  Nagata Y, Yamamoto T, Hayashi M, Hayashi S, Kadowaki M.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 1 Pages: e0170577-e0170577
- DOI
  10.1371/journal.pone.0170577
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09234, KAKENHI-PROJECT-15K18873, KAKENHI-PROJECT-16H05276
[Journal Article] PI3K p85alpha Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production.2017
- Author(s)
  Hayashi S., Hamada T., Zinsou D. G. A., Oshiro M., Itoi K., Yamamoto T., Kadowaki M.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 6187-6187
- DOI
  10.1038/s41598-017-06464-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05276, KAKENHI-PROJECT-16K15408, KAKENHI-PROJECT-15K18873
[Journal Article] Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation.2016
- Author(s)
  Yamada-Nomoto K, Yoshino O, Akiyama I, Ushijima A, Ono Y, Shima T, Nakashima A, Hayashi S, Kadowaki M, Osuga Y, Saito S.
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: 76 Issue: 6 Pages: 491-498
- DOI
  10.1111/aji.12592
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462479, KAKENHI-PROJECT-15K18873
[Journal Article] Induction of regulatory T cells as a novel mechanism underlying the therapeutic action of kakkonto, a traditional Japanese herbal medicine, in a murine food allergy model2016
- Author(s)
  Yamamoto T, Fujiwara K, Tsubota Y, Kageyama-Yahara N, Hayashi S, Kadowaki M
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 169 Issue: 3 Pages: 146-156
- DOI
  10.1159/000445433
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460891, KAKENHI-PROJECT-16H05276
[Journal Article] Induction of Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto, a Traditional Japanese Herbal Medicine, in a Murine Food Allergy Model.2016
- Author(s)
  Yamamoto T, Fujiwara K, Tsubota Y, Kageyama-Yahara N, Hayashi S, Kadowaki M.
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 169 Pages: 146-156
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18873
[Journal Article] Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin.2016
- Author(s)
  Takeuchi K, Endoh T, Hayashi S, Aihara T.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 7
- DOI
  10.3389/fphar.2016.00278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18873
[Journal Article] Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.2015
- Author(s)
  Takeuchi K, Kita K, Takahashi K, Aihara E, Hayashi S.
- Journal Title
  
  Journal of Physiology and Pharmacology
  
  Volume: 66 Pages: 391-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18873
[Journal Article] H2S-induced HCO3-secretion in the rat stomach - Involvement of nitric oxide, prostaglandins, and capsaicin-sensitive sensory neurons.2015
- Author(s)
  Takeuchi K, Ise F, Takahashi K, Aihara E, Hayashi S.
- Journal Title
  
  Nitric Oxide
  
  Volume: 46 Pages: 157-164
- DOI
  10.1016/j.niox.2014.11.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18873
[Journal Article] Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells2014
- Author(s)
  Wang X., Hayashi S., Umezaki M., Yamamoto T., Kageyama-Yahara N., Kondo T., Kadowaki M.
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 224 Pages: 117-127
- DOI
  10.1016/j.cbi.2014.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-25460891
[Journal Article] <b>CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast </b><b>cells </b>2014
- Author(s)
  Kim JH., Yamamoto T., Lee J., Yashiro T., Hamada T., Hayashi S., Kadowaki M.
- Journal Title
  
  Biomed. Res.
  
  Volume: 35 Issue: 4 Pages: 285-293
- DOI
  10.2220/biomedres.35.285
- NAID
  130004678584
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460891
[Journal Article] Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model2014
- Author(s)
  Yamamoto T., Kodama T., Lee J., Utsunomiya N., Hayashi S., Sakamoto H., Kuramoto H., Kadowaki M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: 85888-85888
- DOI
  10.1371/journal.pone.0085888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657, KAKENHI-PROJECT-25460891
[Journal Article] TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells2013
- Author(s)
  Oda S., Uchida K., Wang X., Lee J., Shimada Y., Tominaga M., Kadowaki M.
- Journal Title
  
  Pflugers Archiv : European journal of physiology
  
  Volume: 465 Issue: 3 Pages: 895-900
- DOI
  10.1016/j.bbrc.2012.12.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657, KAKENHI-PROJECT-25460891
[Journal Article] Cinacalcet a Calcimimetic, Prevents Nonsteroidal Anti- inflammatory Drug–Induced Small Intestinal Damage in Rats2013
- Author(s)
  Hayashi S, Kurata N, Kitahirachi E, Nishimura Y, Amagase K, Yano T, Takeuchi K.
- Journal Title
  
  J Physiol Pharmacol
  
  Volume: 64 Pages: 453-463
- URL
  http://www.jpp.krakow.pl/journal/archive/08_13/pdf/453_08_13_article.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790657
[Journal Article] Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice2012
- Author(s)
  Wang X, Kageyama-Yahara N, Hayashi S, Yamamoto T, Kadowaki M.
- Journal Title
  
  Evid Based Complement Alternat Med
  
  Volume: 2012 Pages: 862743-862743
- DOI
  10.1155/2012/862743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790616, KAKENHI-PROJECT-24406005, KAKENHI-PROJECT-24590879, KAKENHI-PROJECT-24790657
[Patent] 動的ネットワークバイオマーカーとしてのトリプトファニルｔＲＮＡ合成酵素様タンパク質を有効成分として含む、炎症性腸疾患の治療、再燃予防、又は寛解維持のための医薬組成物2024
- Inventor(s)
  林周作, 門脇真, 奥牧人, 齋藤滋, 合原一幸, 井村順一
- Industrial Property Rights Holder
  林周作, 門脇真, 奥牧人, 齋藤滋, 合原一幸, 井村順一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-014859
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] 大腸上皮BLT1は傷害された粘膜の治癒に寄与する2024
- Author(s)
  林周作, Miguel Quiros, 奥牧人, Charles A. Parkos, Asma Nusrat
- Organizer
  日本薬学会第114年会
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] 傷害された大腸粘膜の治癒における大腸上皮細胞BLT1の役割2024
- Author(s)
  林周作, Miguel Quiros, 奥牧人, Charles A. Parkos, Asma Nusrat
- Organizer
  第51回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] 大腸炎マウスの腸管神経系における神経新生の解析2023
- Author(s)
  林周作, 宮田佳奈, 山本武, 門脇真
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] Comprehensive mathematical understanding of the complex control system between organs, and challenge for ultra-early precision medicine.2023
- Author(s)
  Hayashi S, Oku M, Akagi K, Taketani A, Oshima Y, Koizumi K, Kadowaki M, Saito S.
- Organizer
  Japan-U.S. Research Collaboration Week: Tracking our health trajectories
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] Berberine, a fatty acid synthase activator, enhances IL-10 production in macrophages and suppresses relapse in murine colitis model.2023
- Author(s)
  Hayashi S, Ogawa Y, Yamamoto T, Kadowaki M.
- Organizer
  Digestive Disease Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] Preferential neurogenesis of nitrergic neurons in the myenteric plexus of DSS colitis mouse colon causes the colonic dysmotility in the colitis.2023
- Author(s)
  Miyata K, Yamamoto T, Hayashi S, Kadowaki M.
- Organizer
  Digestive Disease Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] GPR41-positive enteric sensory neurons are in close proximity to intestinal macrophages in the colonic mucosa of murine colitis model2022
- Author(s)
  Hayashi S, Hertati A, Yamamoto T, Kadowaki M
- Organizer
  Cell Symposia: The Neuro-Immune Axis
- Data Source
  KAKENHI-PROJECT-17KK0166
[Presentation] 腸管上皮BLT1は腸管粘膜の創傷治癒において重要な役割を担う2022
- Author(s)
  林周作, Quiros M, 奥牧人, Parkos CA, Nusrat A
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17KK0166
[Presentation] Neurogenesis and neurodegeneration in enteric neurons of DSS colitis mouse colon2022
- Author(s)
  Miyata K, Ogata H, Yamamoto T, Hayashi S, Kadowaki M
- Organizer
  Cell Symposia: The Neuro-Immune Axis
- Data Source
  KAKENHI-PROJECT-17KK0166
[Presentation] 炎症性腸疾患において再燃予防を実現する治療戦略の提案.2022
- Author(s)
  林周作, 小川雄大, 山本武, 門脇真.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] GPR41-positive enteric sensory neurons are in close proximity to intestinal macrophages in the colonic mucosa of murine colitis model.2022
- Author(s)
  Hayashi S, Hertati A, Yamamoto T, Kadowaki M.
- Organizer
  Cell Symposia: The Neuro-Immune Axis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] Neurogenesis and neurodegeneration in enteric neurons of DSS colitis mouse colon.2022
- Author(s)
  Miyata K, Ogata H, Yamamoto T, Hayashi S, Kadowaki M.
- Organizer
  Cell Symposia: The Neuro-Immune Axis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] 腸管上皮BLT1は腸管粘膜の創傷治癒において重要な役割を担う.2022
- Author(s)
  林周作, Quiros M, 奥牧人, Parkos CA, Nusrat A.
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06593
[Presentation] 炎症性腸疾患において再燃予防を実現する治療戦略の提案2022
- Author(s)
  林周作, 小川雄大, 山本武, 門脇真
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17KK0166
[Presentation] 腸管マクロファージでのIL-10 産生を亢進させるベルベリンは炎症性腸疾患モデルにおける再燃を抑制する.2020
- Author(s)
  小川雄大，林周作，山本武，門脇真.
- Organizer
  富山薬学研究会
- Data Source
  KAKENHI-PROJECT-18K06698
[Presentation] 腸管マクロファージでのIL-10産生亢進作用を有するベルベリンの新規炎症性腸疾患治療薬としての可能性2019
- Author(s)
  小川雄大, 若林ののか, 林周作, 山本武, 門脇真
- Organizer
  第36回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06698
[Presentation] Enhancer of IL-10 production in intestinal macrophages ameliorates an experimental colitis in mice.2018
- Author(s)
  Hayashi S., Wakabayashi N., Ogawa Y., Hertati A., Kadowaki M.
- Organizer
  10th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] Berberine Chloride Suppresses the Development of Murine Acute Colitis due to the Enhancement of IL-10 Production in Macrophages.2018
- Author(s)
  Hayashi S., Wakabayashi N., Kadowaki M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06698
[Presentation] 腸管マクロファージのIL-10産生を亢進する薬物の炎症性腸疾患の治療への応用. シンポジウム「炎症性疾患の病態薬理研究と創薬のための標的分子の提案」.2018
- Author(s)
  林周作, 門脇真.
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18K06698
[Presentation] Role of CD206 Positive Macrophages in the Mucosal Repair after Intestinal Inflammation.2018
- Author(s)
  Hayashi S.、Sendo M.、Hertati A.、Tobe K.、Kadowaki M.
- Organizer
  KEYSTONE SYMPOSIA -The Resolution of Inflammation in Health and Disease-
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] 炎症性腸疾患の病態解明と新たな治療薬の探索研究. 学術奨励賞受賞講演.2018
- Author(s)
  林周作.
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-18K06698
[Presentation] Berberine Chloride, an Enhancer of IL-10 Production in Macrophages, Suppresses the Development of an Experimental Colitis in Mice.2018
- Author(s)
  Hayashi S., Wakabayashi N., Kadowaki M.
- Organizer
  Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] IL-10 を高産生する腸管マクロファージは急性大腸炎の発症を抑制する.2017
- Author(s)
  林周作, ジンスドナルド, 糸井佳奈, 若林ののか, 門脇真.
- Organizer
  第 90 回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] CD206 Positive Intestinal Macrophages Accelerate the Colonic Epithelial Wound Healing.2017
- Author(s)
  Hayashi S.、Zinsou D.、Tobe K.、Kadowaki M.
- Organizer
  18th International Congress of Mucosal Immunology (ICMI2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] CD206 Positive Macrophages is Involved in the Resolution of Intestinal Injury.2017
- Author(s)
  Hayashi S, Zinsou D, Tobe K, Kadowaki M.
- Organizer
  The 19th Takeda Science Foundation Symposium on Bioscience (Chronic Inflammation - Initiation, Progression and Resolution)
- Place of Presentation
  Suita
- Year and Date
  2017-01-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] Search for an Enhancer of IL-10 Production in the Intestinal Macrophages for New Therapy against Inflammatory Bowel Disease.2017
- Author(s)
  Wakabayashi N., Hayashi S., Kadowaki M.
- Organizer
  Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] インシリコスクリーニングを応用した炎症性腸疾患に対する新規治療薬の探索研究.2017
- Author(s)
  窪野孝貴, 林周作, 福西快文, 門脇真
- Organizer
  次世代を担う創薬・医療薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] Intestinal Regulatory T Cells Induced by Kakkonto, a Traditional Japanese Herbal Medicine, Improve Therapeutic Efficacy of Oral Immunotherapy in Food Allergy Model Mice.2017
- Author(s)
  Yamamoto T., Nagata Y., Hayashi M., Kadowaki M
- Organizer
  International Congress of Mucosal Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] Improvement of Therapeutic Efficacy of Oral Immunotherapy in Combination with Regulatory T Cell-inducer Kakkonto in a Murine Food Allergy Model.2017
- Author(s)
  Kadowaki M., Nagata Y., Hayashi M., Hayashi S., Yamamoto T
- Organizer
  East-West Integrative Medicine for Immunology & Wellness
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] CD206 Positive Intestinal Macrophages Contribute to the Colonic Epithelial Wound Healing.2017
- Author(s)
  Hayashi S.、Sendo M.、Hertati A.、Tobe K.、Kadowaki M.
- Organizer
  The 5th Annual Meeting of the International Cytokine & Interferon Society (Cytokine 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] Role of CD206 positive macrophages in the intestinal wound healing.2016
- Author(s)
  林周作, Putu Era Sandhi Kusuma Yuda, 濱田貴之, 戸邉一之, 門脇真.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] 腸管マクロファージの IL-10 産生亢進を標的とした炎症性腸疾患に対する新規治療戦略.2016
- Author(s)
  林周作, 濱田貴之, ジンスドナルド, 門脇真.
- Organizer
  生体機能と創薬シンポジウム 2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] インシリコスクリーニングを用いた炎症性腸疾患に対する新規治療薬の探索.2016
- Author(s)
  窪野孝貴, 林周作, 梅嵜雅人, 門脇真
- Organizer
  日本薬学会北陸支部第128回例会
- Data Source
  KAKENHI-PROJECT-16H05276
[Presentation] PI3 Kinase p85α Subunit-Deficient Macrophages Suppress the Development of DSS-induced Acute Colitis due to the Enhancement of IL-10 Production.2016
- Author(s)
  Hayashi S, Hamada T, Itoi K, Kadowaki M.
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  San Diego
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] PI3Kp85αの欠損は腸管マクロファージのIL-10産生能を増強しDSS誘起大腸炎の発症を抑制する.2015
- Author(s)
  林周作, 濱田貴之, 門脇真.
- Organizer
  第52回日本消化器免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] PI3 kinase p85α subunit-deficient macrophages protect mice from DSS-induced acute colitis due to the enhancement of anti-inflammatory cytokine production.2015
- Author(s)
  Hayashi S., Hamada T., Kadowaki M.
- Organizer
  17th International Congress of Mucosal Immunology (ICMI2015)
- Place of Presentation
  Berlin
- Year and Date
  2015-07-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18873
[Presentation] ニコチンはIL-6/Stat3経路の阻害を介して大腸炎関連発がんを抑制する2014
- Author(s)
  林周作,濱田貴之,石井陽子,笹原正清,門脇真
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] Nicotine Suppresses Colonic Tumorigenesis Associated with Chronic Colitis through the Inhibition of IL-6/Stat3 Pathway in Mice2014
- Author(s)
  Shusaku Hayashi, Takayuki Hamada, Yoko Ishii, Masakiyo Sasahara, Makoto Kadowaki
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] Nicotine Suppresses Colonic Tumorigenesis Associated with Chronic Colitis in Mice through the Inhibition of IL-6 and TNF-αExpression2013
- Author(s)
  Hayashi S, Hamada T, Kadowaki M
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, USA.
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] DSS誘起大腸炎モデルマウスにおける腸管マクロファージの機能制御を介したPI3K p85αの役割2013
- Author(s)
  濱田貴之,林周作,門脇真
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Year and Date
  2013-11-17
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] ニコチンは大腸炎関連発がんの形成を抑制する2013
- Author(s)
  林周作,濱田貴之,門脇真
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] Nicotine suppresses colonic tumorigenesis associated with chronic colitis in mice through the inhibition of IL-6 and TNF-α expression2013
- Author(s)
  Shusaku Hayashi、Takayuki Hamada、Makoto Kadowaki
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando、USA
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] Shikonin suppresses the activation of mucosal mast cells through the inhibition of nuclear orphan receptors NR4A expression2012
- Author(s)
  Hayashi S, Wang X, Umezaki M, Yamamoto T, Kadowaki M.
- Organizer
  5th International Symposium on Scientific Research of Traditional Medicine
- Place of Presentation
  富山
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] マウスDSS誘起大腸炎におけるPI3K p85αサブユニットの役割2012
- Author(s)
  林周作,大城百恵,山本武,門脇真
- Organizer
  第49回日本消化器免疫学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] 紫雲膏の主要活性成分シコニンの核内オーファン受容体NR4Aの遺伝子発現抑制を介したマスト細胞に対する作用2012
- Author(s)
  王暁宇,林周作,山本武,門脇真
- Organizer
  第29回和漢医薬学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790657
[Presentation] a7ニコチン受容体によるJAK2-カスパーゼの活性を介した形質細胞様樹状細胞遊走抑制作用2012
- Author(s)
  山本武,金内優也,林周作,門脇真
- Organizer
  第14回日本神経消化器病学会
- Place of Presentation
  大阪
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-24790657

1. Yamamoto Takeshi (70316181)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. Kadowaki Makoto (20305709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. 柴原直利 (10272907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 東田千尋 (10272931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山西芳裕 (60437267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 梅嵜雅人 (80534370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 長田夕佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Shusaku 林 周作

HAYASHI SHUUSAKU 林 周作

HAYASHI Shusaku 林 周作

Research Projects

Research Products

Co-Researchers

Pathophysiological significance of Wars, a Me-byo gene, in inflammatory bowel diseasePrincipal Investigator

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Creation of New Therapeutic Strategy for Inflammatory Bowel Disease Aiming to Prevent Relapse Based on Rebuilding Mucosal BarrierPrincipal Investigator

Principal Investigator

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A Research of Epithelium-Immune Interaction during Mucosal Repair in Inflammatory Bowel DiseasePrincipal Investigator

Principal Investigator

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Development of Novel Therapeutic Medicines for Inflammatory Bowel Disease with Enhancement of IL-10 Production in Intestinal MacrophagesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Mode-of-action analysis of Kampo formulae and prediction of their new indications for a wide range of diseases

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Role of CD206 Positive Macrophages in the Intestinal Homeostasis and Inflammatory Bowel DiseasePrincipal Investigator

Principal Investigator

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Anti-allergic effect of kakkonto by regulating intestinal mucosal immunity through the induction of regulatory T cells in the colon

Principal Investigator

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Search for Therapeutic Drugs Against Ulcerative Colitis-Mechanism Elucidation of DaikenchutoPrincipal Investigator

Principal Investigator

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[Journal Article] Allergic inflammation disrupts epithelial electrogenic electrolyte transport through cholinergic regulation in the mouse colon2023

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[Journal Article] Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells2022

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[Journal Article] Intestinal epithelial BLT1 promotes mucosal repair2022

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[Journal Article] Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice2021

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[Journal Article] Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan2020

Author(s)

Journal Title

Hayashi Shusaku 林周作

HAYASHI SHUUSAKU 林周作

HAYASHI Shusaku 林周作

[Journal Article] Induction of regulatory T cells as a novel mechanism underlying the therapeutic action of kakkonto, a traditional Japanese herbal medicine, in a murine food allergy model2016