Okudaira Noriyuki 奥平准之

… Alternative Names

OKUDAIRA Noriyuki 奥平准之

Less

Researcher Number	10635585
Other IDs	https://orcid.org/0009-0006-8418-7600
Affiliation (Current)	2024: 帝京大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 帝京大学, 医学部, 助教 2020 – 2022: 埼玉医科大学, 医学部, 実験助手 2015 – 2018: 明海大学, 歯学部, 助教 2012 – 2015: 兵庫医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Legal medicine / Basic Section 59040:Nutrition science and health science-related / Basic Section 38050:Food sciences-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57010:Oral biological science-related / Pathobiological dentistry/Dental radiology / Legal medicine
Keywords	Principal Investigator レトロエレメント / ゲノム不安定性 / LINE-1 / 老化 / 副腎 / グルココルチコイド / 発がん物質 / PPARα / Sirtuin6 / Sirtuin … More / CREB / retrotransposition / resveratrol / レスベラトロール / PPAR / SIRT6 / レトロトランスポゾン / DSB / TLR4 / クエン酸フェンタニル / モルヒネ / レトロトランスポジション / MAPK / NR2A / イミプラミン / 乱用薬物 / 遺伝子改変マウス / miRNA / 遺伝子組換えマウス / 心電図 / 胸腺 / 突然死 / RyR2 … More Except Principal Investigator クロモン誘導体 / ハイパーサーミア / 選択毒性 / QSAR / 口腔扁平上皮癌細胞 / 腫瘍選択性 / Geranylgeraniol / 細胞透過性ペプチド / ハイパーサミア / マイルドハイパーサーミア / 併用療法 / 口腔癌 / 腫瘍選択性磁性体 / 低侵襲性治療 / シグナル伝達 / 口腔扁平上皮癌 / 細胞死 / 代謝物変化 / 遺伝子発現 / 作用点 / クロモン誘導体の標識 / 細胞への取り込み / ヒト口腔扁平上皮がん細胞 / 細胞死のタイプ / パスウェイ解析 / キナーゼ阻害活性 / 抗炎症効果 / 構造活性相関 / 相乗効果 / 3-クロモン誘導体 / エストロゲン関連受容体 / 神経毒性 / ケラチノサイト毒性 / 口腔扁平上皮がん細胞 / 副作用の緩和 / 作用機序 / 有機合成 / ヒト口腔扁平上皮癌 / 3-スチリルクロモン類 / 化学記述子 / 置換基 / オーロン / ピペリン酸エステル / スチリルクロモン / subG1 / アポトーシス誘導能 / 3次元構造 / QSAR解析 / カスパーゼ-3 / 細胞周期 / 分子軌道解析 / アポトーシス / クロモン環 / 遺伝性不整脈原因遺伝子 / カルシウム動態 / RyR2 / 不整脈 / 突然死 / 胸腺 Less

老化による副腎皮質組織のグルココルチコイド分泌撹乱とゲノム不安定性との連関性Principal Investigator
- Principal Investigator
  
  奥平准之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Teikyo University
加熱食品由来発癌物質のゲノム不安定性作用に対するレスベラトロールの遺伝子制御機構Principal Investigator
- Principal Investigator
  
  奥平准之
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Teikyo University
Elucidation of selective cytotoxicity against malignant cells by chromone derivatives
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Meikai University
Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
- Principal Investigator
  
  藤内祝
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Long interspersed element-1 retrotransposition induced by abuse drugsPrincipal Investigator
- Principal Investigator
  
  OKUDAIRA Noriyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Legal medicine
- Research Institution
  Meikai University
Pathophysiological study of the mice with thymicolymphaticus-like phenotypes
- Principal Investigator
  
  Nishio Hajime
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Hyogo Medical University
Immunobiological analysis of cardiac muscle type ryanodine receptor genetic mutation micePrincipal Investigator
- Principal Investigator
  
  OKUDAIRA Noriyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Legal medicine
- Research Institution
  Hyogo Medical University

All 2022 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6.2022
- Author(s)
  Okudaira N, Ishizaka Y, Tamamori-Adachi M
- Journal Title
  
  Sci. Rep.
  
  Volume: 12 Issue: 1 Pages: 7772-7772
- DOI
  10.1038/s41598-022-11761-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11651, KAKENHI-PROJECT-20K05943, KAKENHI-PROJECT-22K11788
[Journal Article] 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone hydrochloride and Related Compounds: Potent Cytotoxins Demonstrating Greater Toxicity to Neoplasms Than Non-Malignant Cells2022
- Author(s)
  Roayapalley Praveen Kumar、Dimmock Jonathan R.、Sakagami Hiroshi、Okudaira Noriyki、Sharma Rajendra K.、Das Umashankar
- Journal Title
  
  Medicinal Chemistry
  
  Volume: 18 Issue: 9 Pages: 1001-1012
- DOI
  10.2174/1573406418666220322154110
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、UESAWA YOSHIHIRO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 7 Pages: 3897-3906
- DOI
  10.21873/anticanres.12674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones2018
- Author(s)
  NAGAI JUNKO、SHI HAIXIA、KUBOTA YUKA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4449-4457
- DOI
  10.21873/anticanres.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4459-4467
- DOI
  10.21873/anticanres.12748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] :Quantitative structure-cytotoxicity relationship of 2-azolylchromones2018
- Author(s)
  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 763-770
- DOI
  10.21873/anticanres.12282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of cinnamic acid phenetyl esters2018
- Author(s)
  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 817-823
- DOI
  10.21873/anticanres.12289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Induction of Apoptosis in human oral keratinocyte by doxorubicin.2017
- Author(s)
  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H and Oizumi T
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 3 Pages: 1023-1029
- DOI
  10.21873/anticanres.11412
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] トランスポゾンの歴史と食品への利用2016
- Author(s)
  奥平准之
- Journal Title
  
  New Food Industry
  
  Volume: 58 Pages: 29-32
- NAID
  40020832743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19278
[Journal Article] Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.2016
- Author(s)
  Okudaira N, Ishizaka Y, Nishio H, Sakagami H.
- Journal Title
  
  IN vivo
  
  Volume: 30 Pages: 113-118
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19278
[Journal Article] Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.2016
- Author(s)
  Okudaira N, Ishizaka Y, Nishio H, Sakagami H.
- Journal Title
  
  In Vivo
  
  Volume: 30 Pages: 113-118
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] ピラノ[4,3-b]クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  永井純子、史海霞、久保田夕香、坂東健二郎、奥平准之、植沢芳広、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 3-(N-サイクリックアミノ)クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  坂上宏、史　海霞、永井純子、坂詰つかさ、坂東健二郎、奥平　准之、植沢芳広、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] Long interspersed element-1 retrotransposition induced by imipramine depends on NR2A.2018
- Author(s)
  Okudaira N.
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] LINE-1 retrotransposition by peroxisome proliferator-activated receptor α inhibited by resveratrol2017
- Author(s)
  奥平准之、石坂幸人
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] Involvement of long interspersed element 1 Retrotransposition induced by imipramine.2017
- Author(s)
  奥平准之、坂上宏
- Organizer
  第90回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] 食品成分由来の発がん物質ヘテロサイクリックアミンのレトロトランスポジション2017
- Author(s)
  奥平准之
- Organizer
  日本食品免疫学会第13回学術大会（JAFI2017）
- Invited
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] 体細胞におけるLINE-1レトロトランスポジションの転移機構2017
- Author(s)
  奥平准之
- Organizer
  日薬レトロポゾン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] フラノクロモン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、高尾浩一、杉田義、加賀谷肇、奥平准之、坂上宏
- Organizer
  第138回日本薬理学会関東部会、慶応義塾大学薬学部、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] Involvement of long interspersed element 1 Retrotransposition induced by imipramine.2017
- Author(s)
  奥平准之、坂上宏.
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] ドキソルビシンのヒト口腔ケラチノサイトに対する傷害性を緩和する物質の探索2016
- Author(s)
  坂上宏、奥平准之、天野修、横瀬敏志
- Organizer
  第58回歯科基礎医学会総会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] Analysis of long interspersed element 1 Retrotransposition in various drugs2016
- Author(s)
  奥平准之、坂上宏
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] 鎮痛薬のLong Interspersed Element 1転移機構2015
- Author(s)
  奥平准之、西口美紀、主田英之、大塚洋輔、西尾元
- Organizer
  第99回日本法医学会
- Place of Presentation
  高知
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15K19278
[Presentation] 心筋型リアノジン受容体遺伝子変異マウス（RyR2-R420W mice）の病態解析2013
- Author(s)
  奥平　准之
- Organizer
  日本法医学会（北海道総会）
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24890282
[Presentation] Mice with the R420W Cardiac Ryanodine Receptor Mutation Exhibit Status Thymicolymphaticus-Like Phenotypes(心筋型リアノジン受容体遺伝子(RyR2)変異マウスの免疫生物学的機能解析)2013
- Author(s)
  奥平准之、西尾元
- Organizer
  第36回日本分子生物学会年会演題番号
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24890282
[Presentation] 筋型リアノジン受容体遺伝子変異マウス(RyR2-R420W mice)の病態解析2013
- Author(s)
  奥平准之、森川公子、西口美紀、主田英之、大内晴美、佐藤貴子、鈴木廣一、西尾元心
- Organizer
  第97次日本法医学会学術全国集会
- Year and Date
  2013-06-28
- Data Source
  KAKENHI-PROJECT-24890282
[Presentation] 心筋型リアノジン受容体遺伝子変異マウス（RyR2-R420W mice）の病態解析
- Author(s)
  奥平准之、森川公子、西口美紀、主田英之、大内晴美、佐藤貴子、鈴木廣一、西尾元
- Organizer
  第97次日本法医学会学術全国集会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24890282
[Presentation] 心筋型リアノジン受容体遺伝子変異マウス（RyR2-R420W mice）の病態解析
- Author(s)
  奥平准之、森川公子、西口美紀、主田英之、大内晴美、佐藤貴子、鈴木廣一、西尾元
- Organizer
  第97次日本法医学会学術全国集会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293164
[Presentation] Mice with the R420W Cardiac Ryanodine Receptor Mutation Exhibit Status Thymicolymphaticus-Like Phenotypes
- Author(s)
  奥平准之、西尾元
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25293164
[Presentation] Mice with the R420W Cardiac Ryanodine Receptor Mutation Exhibit Status Thymicolymphaticus-Like Phenotypes
- Author(s)
  奥平准之、西尾元
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24890282

1. Sakagami Hiroshi (50138484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. BANDOW KENJIRO (50347093)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. 杉田義昭 (20255029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. 高尾浩一 (70337484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. 植沢芳広 (90322528)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. 友村美根子 (30217559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 天野滋 (90167958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Nishio Hajime (90253260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. NAGAI JUNKO (50828142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 杉本昌弘 (30458963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 須永克佳 (70236040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田沼靖一 (10142449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐藤聡 (40530663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤内祝 (50172127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山本信治 (60385185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中鍛治里奈 (80845511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 坂下英明 (10178551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 友村明人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. 安達三美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okudaira Noriyuki 奥平 准之

OKUDAIRA Noriyuki 奥平 准之

Research Projects

Research Products

Co-Researchers

老化による副腎皮質組織のグルココルチコイド分泌撹乱とゲノム不安定性との連関性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加熱食品由来発癌物質のゲノム不安定性作用に対するレスベラトロールの遺伝子制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of selective cytotoxicity against malignant cells by chromone derivatives

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Long interspersed element-1 retrotransposition induced by abuse drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiological study of the mice with thymicolymphaticus-like phenotypes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunobiological analysis of cardiac muscle type ryanodine receptor genetic mutation micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone hydrochloride and Related Compounds: Potent Cytotoxins Demonstrating Greater Toxicity to Neoplasms Than Non-Malignant Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] :Quantitative structure-cytotoxicity relationship of 2-azolylchromones2018

Author(s)

Okudaira Noriyuki 奥平准之

OKUDAIRA Noriyuki 奥平准之