Fujita Yu 藤田雄

Researcher Number	10737133
Other IDs	https://orcid.org/0000-0002-8916-7303
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京慈恵会医科大学, 医学部, 准教授 2020 – 2022: 東京慈恵会医科大学, 医学部, 講師 2019: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 55030:Cardiovascular surgery-related / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator COPD / エクソソーム / サルコペニア / 糖鎖 / scRNA-seq / 肺オルガノイド / scRNAseq / II型肺胞上皮細胞 / 2型肺胞上皮 / 細胞外小胞 … More / II型肺胞上皮 / IPF / 老化 / microRNA / SASP / 肺がん / 特発性肺線維症 … More Except Principal Investigator エクソソーム / 血管新生阻害薬 / 癌微小環境 / microRNA / 血管内皮細胞 / 肝細胞癌 / 細胞外小胞 / マイクロRNA / リンパ管内皮細胞 / 間葉系幹細胞 / リンパ浮腫 / 細胞外分泌小顆粒 / metabolic reprograming / 細胞外分泌小胞顆粒 / 特発性肺線維症 / Extracellular vesicle / 幹細胞性 / II型肺胞上皮細胞 / lipofibroblast / 慢性閉塞性肺疾患 Less

miRNA誘導リンパ管内皮細胞と間葉系幹細胞による二次性リンパ浮腫治療の研究開発
- Principal Investigator
  
  村橋睦了 (伊賀睦了)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Jikei University School of Medicine
Development of a novel EV treatment for pulmonary fibrosis through induction of lipofibroblast differentiation.
- Principal Investigator
  
  Araya Jun
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
エクソソーム表面糖鎖を基軸としたCOPDサルコペニア病態解明とsenotherapyの開発Principal Investigator
- Principal Investigator
  
  藤田雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
肝癌微小環境における癌関連血管内皮細胞の分子生物学的機能解明と革新的治療法開発
- Principal Investigator
  
  春木孝一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Pathogenesis via a novel type 2 alveolar epithelial cell subgroup in COPDPrincipal Investigator
- Principal Investigator
  
  Fujita Yu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
The roles of senescence-related exosomes in the lung cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Fujita Yu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling2024
- Author(s)
  Fujita Yu、Kadota Tsukasa、Kaneko Reika、Hirano Yuta、Fujimoto Shota、Watanabe Naoaki、Kizawa Ryusuke、Ohtsuka Takashi、Kuwano Kazuyoshi、Ochiya Takahiro、Araya Jun
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 514-514
- DOI
  10.1038/s42003-024-06197-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-24K02461
[Journal Article] Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration2024
- Author(s)
  Fujimoto Shota、Hirano Yuta、Watanabe Naoaki、Matsubayashi Sachi、Inukai Shun、Nishioka Saiko、Yoshida Masahiro、Ito Saburo、Minagawa Shunsuke、Hara Hiromichi、Ohtsuka Takashi、Wiriyasermkul Pattama、Nagamori Shushi、Kuwano Kazuyoshi、Araya Jun、Fujita Yu
- Journal Title
  
  bioRxiv
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-24K02461
[Journal Article] Fibroblast-Derived Extracellular Vesicles Induce Lung Cancer Progression in the IPF Microenvironment2023
- Author(s)
  Fujita Yu、Fujimoto Shota、Miyamoto Atsushi、Kaneko Reika、Kadota Tsukasa、Watanabe Naoaki、Kizawa Ryusuke、Kawamoto Hironori、Watanabe Junko、Utsumi Hirofumi、Wakui Hiroshi、Minagawa Shunsuke、Araya Jun、Ohtsuka Takashi、Ochiya Takahiro、Kuwano Kazuyoshi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: online ahead of print Issue: 1 Pages: 34-44
- DOI
  10.1165/rcmb.2022-0253oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08213, KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-20K08578
[Journal Article] Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration.2022
- Author(s)
  Kadota T, Fujita Y, Araya J, Ochiya T, Kuwano K.
- Journal Title
  
  Eur Respir Rev
  
  Volume: 31(163) Issue: 163 Pages: 210106-210106
- DOI
  10.1183/16000617.0106-2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02930
[Journal Article] Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease2022
- Author(s)
  Watanabe Naoaki、Fujita Yu、Nakayama Jun、Mori Yutaro、Kadota Tsukasa、Hayashi Yusuke、Shimomura Iwao、Ohtsuka Takashi、Okamoto Koji、Araya Jun、Kuwano Kazuyoshi、Yamamoto Yusuke
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 67 Issue: 6 Pages: 708-719
- DOI
  10.1165/rcmb.2021-0555oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02721, KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-20J01794, KAKENHI-PROJECT-21K15562
[Journal Article] Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk2021
- Author(s)
  Kadota Tsukasa、Fujita Yu、Araya Jun、Watanabe Naoaki、Fujimoto Shota、Kawamoto Hironori、Minagawa Shunsuke、Hara Hiromichi、Ohtsuka Takashi、Yamamoto Yusuke、Kuwano Kazuyoshi、Ochiya Takahiro
- Journal Title
  
  Journal of Extracellular Vesicles
  
  Volume: 10 Issue: 10
- DOI
  10.1002/jev2.12124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02721, KAKENHI-PROJECT-21H02930
[Journal Article] Intercellular Communication by Vascular Endothelial Cell-Derived Extracellular Vesicles and Their MicroRNAs in Respiratory Diseases2021
- Author(s)
  Fujimoto Shota、Fujita Yu、Kadota Tsukasa、Araya Jun、Kuwano Kazuyoshi
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 7 Pages: 619697-619697
- DOI
  10.3389/fmolb.2020.619697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17649
[Journal Article] Chaperone-mediated autophagy receptor modulates tumor growth and chemoresistance in non-small cell lung cancer2020
- Author(s)
  Ichikawa A, Fujita Y, Hosaka Y, Kadota T, Ito A, Yagishita S, Watanabe N, Fujimoto S, Kawamoto H, Saito N, Yoshida M, Hashimoto M, Minagawa S, Hara H, Motoi N, Yamamoto Y, Ochiya T, Araya J, Kuwano K.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 11 Pages: 4154-65
- DOI
  10.1111/cas.14629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07036, KAKENHI-PROJECT-19K17649
[Journal Article] Extracellular Vesicles from Fibroblasts Induce Epithelial-Cell Senescence in Pulmonary Fibrosis2020
- Author(s)
  Kadota Tsukasa、Yoshioka Yusuke、Fujita Yu、Araya Jun、Minagawa Shunsuke、Hara Hiromichi、Miyamoto Atsushi、Suzuki Souichiro、Fujimori Sakashi、Kohno Tadasu、Fujii Takeshi、Kishi Kazuma、Kuwano Kazuyoshi、Ochiya Takahiro
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 63 Issue: 5 Pages: 623-636
- DOI
  10.1165/rcmb.2020-0002oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17649
[Presentation] Development of Extracellular Vesicle-based Therapy for Respiratory Diseases2024
- Author(s)
  藤田雄
- Organizer
  第23回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02930
[Presentation] Lipofibroblast由来細胞外小胞を用いた慢性閉塞性肺疾患に対する新規治療法の開発2023
- Author(s)
  藤本祥太、藤田雄、渡邉直昭、犬養舜、西岡彩子、平野悠太、松林沙知、竹越大輔、伊藤三郎、皆川俊介、原弘道、荒屋潤
- Organizer
  第10回細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Lipofibroblast derived-extracellular vesicles attenuate cigarette smoke-induced lung injury2023
- Author(s)
  S. Fujimoto, Y. Fujita, N. Watanabe, S. Matsubayashi, H. Kawamoto, D. Takekoshi, S. Ito, S. Minagawa, H. Hara, J. Araya, K. Kuwano
- Organizer
  ERS congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Lipofibroblast derived-extracellular vesicles attenuate cigarette smoke-induced lung injury.2023
- Author(s)
  Shota Fujimoto, Yu Fujita, Jun Araya, Kazuyoshi Kuwano
- Organizer
  2023 Asia Pacific Societies for Extracellular Vesicles (APSEV) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] 細胞外小胞治療用製剤の開発現状と展望2023
- Author(s)
  藤田雄
- Organizer
  第10回日本細胞外小胞学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02930
[Presentation] Lipofibroblast由来細胞外小胞を用いた肺線維症に対する治療効果の検討2023
- Author(s)
  藤本祥太、藤田雄、荒屋潤、桑野和善
- Organizer
  第63回呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] 線維芽細胞由来細胞外小胞を用いた肺線維化抑制効果の検討.2022
- Author(s)
  藤本祥太、藤田雄、金子麗華、荒屋潤、桑野和善
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Small RNAおよびエクソソームを用いた難治性呼吸器疾患における病態解明と治療法開発2021
- Author(s)
  藤田雄
- Organizer
  第61回日本呼吸器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02930
[Presentation] Small RNAおよびエクソソームを用いた難治性呼吸器疾患における病態解明と治療法開発2021
- Author(s)
  藤田雄
- Organizer
  第61回日本呼吸器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17649
[Presentation] 肺線維化に対する気道上皮細胞由来エクソソームを用いた新規治療戦略2020
- Author(s)
  藤田雄
- Organizer
  第60回日本呼吸器学会学術講演会若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K17649

1. Araya Jun (90468679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 村橋睦了 (20422420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 宮本将平 (20758536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鎌田裕子 (60433984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 春木孝一郎 (60720894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 池上徹 (80432938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 古川賢英 (80624973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 恩田真二 (10459620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 白井祥睦 (10785364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 柳垣充 (80979435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 谷合智彦 (60961860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 桑野和善

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 元井紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujita Yu 藤田 雄

Research Projects

Research Products

Co-Researchers

miRNA誘導リンパ管内皮細胞と間葉系幹細胞による二次性リンパ浮腫治療の研究開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel EV treatment for pulmonary fibrosis through induction of lipofibroblast differentiation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エクソソーム表面糖鎖を基軸としたCOPDサルコペニア病態解明とsenotherapyの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝癌微小環境における癌関連血管内皮細胞の分子生物学的機能解明と革新的治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis via a novel type 2 alveolar epithelial cell subgroup in COPDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of senescence-related exosomes in the lung cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration2024

Author(s)

Journal Title

Data Source

[Journal Article] Fibroblast-Derived Extracellular Vesicles Induce Lung Cancer Progression in the IPF Microenvironment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intercellular Communication by Vascular Endothelial Cell-Derived Extracellular Vesicles and Their MicroRNAs in Respiratory Diseases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chaperone-mediated autophagy receptor modulates tumor growth and chemoresistance in non-small cell lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Vesicles from Fibroblasts Induce Epithelial-Cell Senescence in Pulmonary Fibrosis2020

Fujita Yu 藤田雄

[Presentation] Small RNAおよびエクソソームを用いた難治性呼吸器疾患における病態解明と治療法開発2021