Shirai Yoshihiro 白井祥睦

Researcher Number	10785364
Other IDs	https://orcid.org/0000-0002-4907-0101
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 富山大学, 学術研究部医学系, 助教 2016 – 2023: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery
Keywords	Principal Investigator オートファジー / 膵臓癌 / Lysosome酵素 / ライソゾーム / 遺伝子治療 / 抗癌剤耐性 / 酸性αグルコシダーゼ / 腫瘍免疫 / MHCクラスI / 免疫回避機構 … More / ライソゾーム酵素 / スフィンゴリン脂質 / ミトコンドリア / 膵切除 / グルコセレブロシダーゼ / 酸性セラミダーゼ / マイトファジー / アデノウイルスベクター / 酸性さらみだーぜ / Lysosome … More Except Principal Investigator 癌微小環境 / 肝細胞癌 / オートファジー / 肝癌 / ライソゾーム / 膵臓癌 / エクソソーム / アポトーシス / マイトファジー / 複合免疫療法 / microRNA / 血管内皮細胞 / 癌免疫 / レンバチニブ / 薬剤耐性 / 分子標的薬 / アクアポリン / 再発 / 転移 / 乳癌 / 酸性β-グルコシダーゼ / ライソゾーム酵素 / 酸性セラミダーゼ / 腫瘍免疫 / 化学療法抵抗性 / 腸内細菌 / miRNA / アデノウイルスベクター / Parkin / ミトコンドリア / 肝虚血再灌流障害 / 肝虚血再灌障害 Less

アクアポリンを標的とした乳癌休眠細胞の再活性化・転移・再発機構の解明
- Principal Investigator
  
  関根慎一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  University of Toyama
癌微小環境に着目した肝細胞癌の分子標的薬耐性メカニズム解明と革新的治療法の開発
- Principal Investigator
  
  恩田真二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
肝細胞癌の宿主免疫回避機構の解明に基づく新たな治療戦略の開発
- Principal Investigator
  
  池上徹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
肝癌微小環境における癌関連血管内皮細胞の分子生物学的機能解明と革新的治療法開発
- Principal Investigator
  
  春木孝一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Analysis of lysosome enzymes in pancreatic cancer specific immune evasion systemPrincipal Investigator
- Principal Investigator
  
  白井祥睦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Toyama
免疫微小環境を標的とした高悪性度肝細胞癌に対する統合的治療戦略の開発
- Principal Investigator
  
  古川賢英
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
The molecular mechanism of hepatocellular carcinoma associated fibroblast oriented exosome miRNA
- Principal Investigator
  
  Ikegami Toru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Microbiome and chemoresistance in pancreatic cancer
- Principal Investigator
  
  Haruki Koichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Development of innovative treatments based on pancreatic cancer-specific energy metabolism mechanisms.
- Principal Investigator
  
  Uwagawa Tadashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Analysis of lysosomal metabolism in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Shirai Yoshihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
Autophagy and mitophagy in advanced hepatocellular carcinoma
- Principal Investigator
  
  Ikegami Toru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
  Kyushu University
Analysis of lysosome in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Shirai Yoshihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Jikei University School of Medicine
Parkin-dependent mitophagy in hepatic ischemia-reperfusion injury
- Principal Investigator
  
  Yanaga Katsuhiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Jikei University School of Medicine

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Effect of Risk Factor Score on Early Recurrence After Pancreatectomy for Invasive Pancreatic Ductal Adenocarcinoma2024
- Author(s)
  Matsumoto M, Shirai Y, Abe K, Futagawa Y, Haruki K, Furukawa K, Onda S, Hamura R, Tanji Y, Tsunematsu M, Shiozaki H, Okamoto T, Ikegami T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 44 Issue: 4 Pages: 1695-1702
- DOI
  10.21873/anticanres.16968
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15506, KAKENHI-PROJECT-23K08202
[Journal Article] The Signal intensity ratio of pancreas to spleen in magnetic resonance imaging can predict non-alcoholic fatty liver disease following pancreaticoduodenectomy2024
- Author(s)
  Masashi Tsunematsu, Koichiro Haruki, Yoshihiro Shirai, Shinji Onda, Kenei Furukawa, Norimitsu Okui, Kyohei Abe, Taro Sakamoto, Takeshi Gocho, Toru Ikegami.
- Journal Title
  
  Pancreas
  
  Volume: 53 Issue: 4 Pages: e310-e316
- DOI
  10.1097/mpa.0000000000002306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16453, KAKENHI-PROJECT-21K08805
[Journal Article] The prognosis-based classification model in resectable pancreatic cancer2024
- Author(s)
  Okui Norimitsu、Tsunematsu Masashi、Furukawa Kenei、Shirai Yoshihiiro、Haruki Koichiro、Sakamoto Taro、Uwagawa Tadashi、Onda Shinji、Gocho Takeshi、Ikegami Toru
- Journal Title
  
  Surgical Oncology
  
  Volume: 52 Pages: 102035-102035
- DOI
  10.1016/j.suronc.2024.102035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16501, KAKENHI-PROJECT-21K08806
[Journal Article] Osteosarcopenia impacts treatment outcomes for Barcelona Cancer Liver Classification stage A hepatocellular carcinoma.2024
- Author(s)
  Abe K, Furukawa K, Matsumoto M, Futagawa Y, Shiozaki H, Onda S, Haruki K, Shirai Y, Okamoto T, Ikegami T.
- Journal Title
  
  Surg Oncol.
  
  Volume: 53 Pages: 102043-102043
- DOI
  10.1016/j.suronc.2024.102043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718
[Journal Article] The postoperative platelet-to-lymphocyte ratio predicts the outcome of patients undergoing pancreaticoduodenectomy for pancreatic head cancer2023
- Author(s)
  Shirai Yoshihiro、Hamura Ryoga、Tanji Yoshiaki、Taniai Tomohiko、Yanagaki Mitsuru、Haruki Koichiro、Furukawa Kenei、Onda Shinji、Sakamoto Taro、Gocho Takeshi、Ikegami Toru
- Journal Title
  
  Surgery Today
  
  Volume: 54 Issue: 3 Pages: 247-257
- DOI
  10.1007/s00595-023-02727-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08202
[Journal Article] Sustained Systemic Inflammatory Response Predicts Survival in Patients with Hepatocellular Carcinoma After Hepatic Resection.2023
- Author(s)
  Haruki K, Taniai T, Yanagaki M, Furukawa K, Tsunematsu M, Onda S, Shirai Y, Matsumoto M, Okui N, Ikegami T.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 30 Issue: 1 Pages: 604-613
- DOI
  10.1245/s10434-022-12464-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718
[Journal Article] Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes.2023
- Author(s)
  Furukawa K, Haruki K, Taniai T, Yanagaki M, Tsunematsu M, Tanji Y, Ishizaki S, Shirai Y, Onda S, Ikegami T.
- Journal Title
  
  Cancers (Basel).
  
  Volume: 15 Issue: 23 Pages: 5513-5513
- DOI
  10.3390/cancers15235513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718
[Journal Article] Open Thoracic Drainage Followed by Proximal Splenic Artery Embolization for Massive Hydrothorax Before Living Donor Liver Transplantation2023
- Author(s)
  Taniai Tomohiko、Haruki Koichiro、Furukawa Kenei、Yanagaki Mitsuru、Hamura Ryoga、Akaoka Munetoshi、Tsunematsu Masashi、Onda Shinji、Shirai Yoshihiro、Uwagawa Tadashi、Ikegami Toru
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 55 Issue: 4 Pages: 884-887
- DOI
  10.1016/j.transproceed.2023.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08805, KAKENHI-PROJECT-22K20804
[Journal Article] A novel combined C‐reactive protein‐albumin ratio and modified albumin‐bilirubin score can predict long‐term outcomes in patients with hepatocellular carcinoma after hepatic resection2023
- Author(s)
  Aida Takashi、Haruki Koichiro、Akaoka Munetoshi、Furukawa Kenei、Onda Shinji、Shirai Yoshihiro、Shiozaki Hironori、Takahashi Keita、Oikawa Tsunekazu、Ikegami Toru
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 8 Issue: 1 Pages: 143-150
- DOI
  10.1002/ags3.12727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16547, KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-21K08805
[Journal Article] Liver Only Living Donor Transplantation for Polycystic Disease in a Patient on Chronic Hemodialysis: Case Report2023
- Author(s)
  Yanagaki Mitsuru、Haruki Koichiro、Furukawa Kenei、Taniai Tomohiko、Akaoka Munetoshi、Shirai Yoshihiro、Abe Kyohei、Onda Shinji、Matsumoto Michinori、Uwagawa Tadashi、Ikegami Toru
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 55 Issue: 4 Pages: 1095-1097
- DOI
  10.1016/j.transproceed.2023.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08805
[Journal Article] Preoperative Therapy for Unresectable Locally Advanced Pancreatic Cancer for >6 Months Improves Prognosis After Pancreatectomy.2023
- Author(s)
  Matsumoto M, Shirai Y, Uwagawa T, Tsunematsu M, Sakamoto T, Fujioka S, Takahashi K, Onda S, Furukawa K, Haruki K, Hamura R, Gocho T, Ikegami T.
- Journal Title
  
  Anticancer Res
  
  Volume: 43 Issue: 9 Pages: 4097-4104
- DOI
  10.21873/anticanres.16599
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15483, KAKENHI-PROJECT-23K08202
[Journal Article] Osteosarcopenia is a significant predictor of recurrence and the prognosis after resection for extrahepatic bile duct cancer2023
- Author(s)
  Matsumoto Michinori、Onda Shinji、Igarashi Yosuke、Hamura Ryoga、Uwagawa Tadashi、Furukawa Kenei、Shirai Yoshihiro、Gocho Takeshi、Haruki Koichiro、Ikegami Toru
- Journal Title
  
  Surgery Today
  
  Volume: 54 Issue: 5 Pages: 407-418
- DOI
  10.1007/s00595-023-02747-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08806
[Journal Article] Dynamics of the prognostic nutritional index in preoperative chemotherapy in patients with colorectal liver metastases.2023
- Author(s)
  Taniai T, Furukawa K, Igarashi Y, Shirai Y, Haruki K, Onda S, Iwase R, Matsumoto M, Fujioka S, Ikegami T.
- Journal Title
  
  Surg Oncol.
  
  Volume: 49 Pages: 101966-101966
- DOI
  10.1016/j.suronc.2023.101966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-22K20804
[Journal Article] Superior mesenteric vein/portal vein contact in preoperative imaging indicates biological malignancy in anatomically resectable pancreatic cancer2023
- Author(s)
  Shirai Yoshihiro、Onda Shinji、Tanji Yoshiaki、Hamura Ryoga、Matsumoto Michinori、Yanagaki Mitsuru、Tsunematsu Masashi、Taniai Tomohiko、Haruki Kochiro、Furukawa Kenei、Abe Kyohei、Sakamoto Taro、Gocho Takeshi、Uwagawa Tadashi、Ikegami Toru
- Journal Title
  
  Surgical Oncology
  
  Volume: 51 Pages: 101998-101998
- DOI
  10.1016/j.suronc.2023.101998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08202
[Journal Article] Clinical significance of cachexia index in patients with hepatocellular carcinoma after hepatic resection.2022
- Author(s)
  Akaoka M, Haruki K, Taniai T, Yanagaki M, Igarashi Y, Furukawa K, Onda S, Tsunematsu M, Shirai Y, Okui N, Gocho T, Ikegami T.
- Journal Title
  
  Surg Oncol.
  
  Volume: 45 Pages: 101881-101881
- DOI
  10.1016/j.suronc.2022.101881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718
[Journal Article] Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer.2022
- Author(s)
  Yanagaki M, Shirai Y, Shimada Y, Hamura R, Taniai T, Horiuchi T, Takada N, Haruki K, Furukawa K, Uwagawa T, Kobayashi H, Ikegami T.
- Journal Title
  
  Carcinogenesis.
  
  Volume: 43 Issue: 9 Pages: 826-837
- DOI
  10.1093/carcin/bgac060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-21K08805, KAKENHI-PROJECT-20K17665
[Journal Article] Preoperative cachexia index can predict the prognosis of extrahepatic biliary tract cancer after resection.2022
- Author(s)
  Hamura R, Haruki K, Shirai Y, Tanji Y, Taniai T, Okui N, Furukawa K, Shiozaki H, Onda S, Ikegami T.
- Journal Title
  
  Surg Oncol.
  
  Volume: 44 Pages: 101825-101825
- DOI
  10.1016/j.suronc.2022.101825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-22K16523, KAKENHI-PROJECT-22K16547
[Journal Article] The clinical management of peripancreatic fluid collection after distal pancreatectomy2022
- Author(s)
  Tsunematsu Masashi、Shirai Yoshihiro、Hamura Ryoga、Taniai Tomohiko、Yanagaki Mitsuru、Haruki Koichiro、Furukawa Kenei、Onda Shinji、Toyama Yoichi、Gocho Takeshi、Ikegami Toru
- Journal Title
  
  Surgery Today
  
  Volume: epub Issue: 11 Pages: 1524-1531
- DOI
  10.1007/s00595-022-02483-x
- Data Source
  KAKENHI-PROJECT-20K17665
[Journal Article] Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases.2022
- Author(s)
  Tanji Y, Furukawa K, Haruki K, Taniai T, Onda S, Tsunematsu M, Shirai Y, Yanagaki M, Igarashi Y, Ikegami T.
- Journal Title
  
  Ann Gastroenterol Surg.
  
  Volume: 6 Issue: 6 Pages: 804-812
- DOI
  10.1002/ags3.12578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08718
[Journal Article] Inhibition of lysosomal acid β-glucosidase induces cell apoptosis via impairing mitochondrial clearance in pancreatic cancer.2022
- Author(s)
  Yanagaki M, Shirai Y, Shimada Y, Hamura R, Taniai T, Horiuchi T, Takada N, Haruki K, Furukawa K, Uwagawa T, Kobayashi H, Ikegami T.
- Journal Title
  
  Carcinogenesis
  
  Volume: 43 Pages: 826-837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08806
[Journal Article] Novel combined fibrosis-based index predicts the long-term outcomes of hepatocellular carcinoma after hepatic resection2022
- Author(s)
  Yanagaki Mitsuru、Shirai Yoshihiro、Hamura Ryoga、Taniai Tomohiko、Tanji Yoshiaki、Haruki Koichiro、Furukawa Kenei、Onda Shinji、Shiba Hiroaki、Ikegami Toru
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 4 Pages: 717-728
- DOI
  10.1007/s10147-021-02111-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17665, KAKENHI-PROJECT-21K15515
[Journal Article] Phase II trial of nafamostat mesilate/gemcitabin/S-1 for unresectable pancreatic cancer.2022
- Author(s)
  Uwagawa T, Sakamoto T, Gocho T, Shiba H, Onda S, Yasuda J, Shirai Y, Hamura R, Furukawa K, Yanaga K, Ikegami T.
- Journal Title
  
  PLoS One
  
  Volume: 17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08806
[Journal Article] The impact of S-1 for the patient with lymph nodal metastasis biliary tract cancer as adjuvant chemotherapy: a multicenter database analysis.2022
- Author(s)
  Hamura R, Haruki K, Taniai T, Yanagaki M, Shirai Y, Furukawa K, Usuba T, Fujioka S, Okamoto T, Nakabayashi Y, Uwagawa T, Ikegami T.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 27 Pages: 1188-1195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08806
[Journal Article] The novel index using preoperative C-reactive protein and neutrophil-to-lymphocyte ratio predicts poor prognosis in patients with pancreatic cancer.2021
- Author(s)
  Taniai T, Haruki K, Furukawa K, Onda S, Yasuda J, Shirai Y, Gocho T, Yanagaki M, Hamura R, Shiba H, Ikegami T.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 26 Issue: 10 Pages: 1922-1928
- DOI
  10.1007/s10147-021-01964-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-21K08805, KAKENHI-PROJECT-21K16390
[Journal Article] Simultaneous dual hepatic vascular embolization (DHVE) for massive hepatectomy2021
- Author(s)
  Haruki K, Furukawa K, Ashida H, Shirai Y, Onda S, Tsunematsu M, Ikegami T.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 28 Issue: 13 Pages: 8246-8246
- DOI
  10.1245/s10434-021-10433-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08805
[Journal Article] The significance of the rapid turnover protein score as a predictor of the long-term outcomes in hepatocellular carcinoma after hepatic resection2021
- Author(s)
  Yanagaki M, Haruki K, Yasuda J, Furukawa K, Onda S, Tsunematsu M, Shirai Y, Gocho T, Taniai T, Hamura R, Ikegami T.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 28 Issue: 13 Pages: 8130-9
- DOI
  10.1245/s10434-021-10704-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08805, KAKENHI-PROJECT-21K15515
[Journal Article] Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells2021
- Author(s)
  Taniai T, Shirai Y, Shimada Y, Hamura R, Yanagaki M, Takada N, Horiuchi T, Haruki K, Furukawa K, Uwagawa T, Tsuboi K, Okamoto Y, Shimada S, Tanaka S, Ohashi T, Ikegami T.
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Pages: 4570-4579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08806
[Journal Article] Thrombomodulin expression impacts the recurrence and long‐term survival in pancreatic cancer2021
- Author(s)
  Sugano Hiroshi、Shirai Yoshihiro、Sato Shun、Hamatani Shigeharu、Hamura Ryoga、Taniai Tomohiko、Horiuchi Takashi、Gocho Takeshi、Eto Ken、Ikegami Toru
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 5 Issue: 4 Pages: 567-574
- DOI
  10.1002/ags3.12447
- Data Source
  KAKENHI-PROJECT-20K17665
[Journal Article] “Graft Recipient Weight Ratio” or “Graft volume standard liver volume ratio” in clinical practice in living donor liver transplantation2021
- Author(s)
  Haruki K, Furukawa K, Onda S, Shirai Y, Ikegami T.
- Journal Title
  
  Ann Gastroenterol Surg
  
  Volume: 5 Issue: 6 Pages: 865-6
- DOI
  10.1002/ags3.12461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08805
[Journal Article] Nafamostat mesilate, a nuclear factor kappa B inhibitor, enhances the antitumor action of radiotherapy on gallbladder cancer cells2021
- Author(s)
  Takada Naoki、Sugano Hiroshi、Shirai Yoshihiro、Saito Nobuhiro、Hamura Ryoga、Taniai Tomohiko、Uwagawa Tadashi、Yanaga Katsuhiko、Ikegami Toru、Ohashi Toya、Eto Ken
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 9 Pages: e0257019-e0257019
- DOI
  10.1371/journal.pone.0257019
- Data Source
  KAKENHI-PROJECT-20K17665
[Journal Article] Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells2021
- Author(s)
  Taniai Tomohiko、Shirai Yoshihiro、Shimada Yohta、Hamura Ryoga、Yanagaki Mitsuru、Takada Naoki、Horiuchi Takashi、Haruki Koichiro、Furukawa Kenei、Uwagawa Tadashi、Tsuboi Kazuhito、Okamoto Yasuo、Shimada Shu、Tanaka Shinji、Ohashi Toya、Ikegami Toru
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 11 Pages: 4570-4579
- DOI
  10.1111/cas.15123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07165, KAKENHI-PROJECT-19K08634, KAKENHI-PROJECT-20K21627, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-20K11571, KAKENHI-PROJECT-21K08718, KAKENHI-PROJECT-20K17665
[Journal Article] Suppression of lysosomal acid alpha‐glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer2021
- Author(s)
  Hamura Ryoga、Shirai Yoshihiro、Shimada Yohta、Saito Nobuhiro、Taniai Tomohiko、Horiuchi Takashi、Takada Naoki、Kanegae Yumi、Ikegami Toru、Ohashi Toya、Yanaga Katsuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 6 Pages: 2335-2348
- DOI
  10.1111/cas.14921
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08195, KAKENHI-PROJECT-20K17665
[Journal Article] Effectiveness of anatomical resection for small hepatocellular carcinoma: a propensity score-matched analysis of a multi-institutional database2021
- Author(s)
  Haruki K, Furukawa K, Fujiwara Y, Taniai T, Hamura R, Shirai Y, Yasuda J, Shiozaki H, Onda S, Gocho T, Shiba H, Usuba T, Nakabayashi Y, Fujioka S, Okamoto T, Ikegami T.
- Journal Title
  
  J Gastrointest Surg
  
  Volume: 25 Issue: 11 Pages: 2835-41
- DOI
  10.1007/s11605-021-04985-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08805
[Journal Article] Small-for-size graft, small-for-size syndrome and inflow modulation in living donor liver transplantation.2020
- Author(s)
  Ikegami T, Onda S, Furukawa K, Haruki K, Shirai Y, Gocho T
- Journal Title
  
  J Hepatobiliary Pancreat Sci.
  
  Volume: 27 Issue: 11 Pages: 799-809
- DOI
  10.1002/jhbp.822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08647
[Presentation] 膵癌患者の組織とリキッドバイオプシー検体を用いた分子プロファイリングの有用性2023
- Author(s)
  柳垣充, 宇和川匡, 上野敏秀, 今井健太, 高橋数冴, 新井田厚司, 恒松雅, 白井祥睦, 春木孝一郎, 古川賢英, 後町武志, 池上徹, 間野博行, 高阪真路
- Organizer
  第82回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 解剖学的切除可能膵癌におけるSMV/PV接触の生物学的意義2023
- Author(s)
  白井祥睦, 丹治芳明, 羽村凌雅, 後町武志, 恒松雅, 奥井紀光, 塩崎弘憲, 阿部恭平, 松本倫典, 坂本太郎, 五十嵐陽介, 谷合智彦, 柳垣充, 赤岡宗紀, 山畑勇統, 春木孝一郎, 安田淳吾, 古川賢英, 恩田真二, 池上徹
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-23K08202
[Presentation] 肝細胞癌におけるARID4Bの分子生物学的意義と予後予測因子としての有用性の検討2023
- Author(s)
  柳垣充, 春木孝一郎, 古川賢英, 恩田真二, 石崎俊太, 恒松雅, 白井祥睦, 奥井紀光, 松本倫典, 坂本太郎, 後町武志, 丹治芳明, 五十嵐陽介, 谷合智彦, 池上徹
- Organizer
  JDDW 2023
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 切除不能膵臓癌に対するconversion surgeryの現状と課題2023
- Author(s)
  白井祥睦、後町武志、羽村凌雅、恩田真二、松本倫典、坂本太郎、藤岡秀一、岡本友好、宇和川匡、池上徹
- Organizer
  第 78 回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-23K08202
[Presentation] 上腸間膜静脈閉塞および胃・十二指腸との交通を伴った膵巨大粘液癌に対して施行した膵全摘出術2022
- Author(s)
  白井祥睦, 恩田真二, 羽村凌雅, 堀内尭, 恒松雅, 奥井紀光, 坂本太郎, 後町武志, 丹治芳明,塩崎弘憲, 池上徹
- Organizer
  第49回日本膵切研究会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] NF-kB阻害剤による膵癌肝転移抑制におけるmiRNA解析2022
- Author(s)
  柳垣　充，白井祥睦，斉藤庸博，羽村凌雅，谷合智彦，丹治芳明，春木　孝一郎，古川賢英，恩田真二，後町武志，池上　徹
- Organizer
  第31回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵癌における酸性βグルコシダーゼ(GBA)阻害はマイトファジー障害とエネルギー代謝不全を誘導する2022
- Author(s)
  柳垣　充，白井祥睦，羽村凌雅，谷合智彦，堀内　尭，春木　孝一郎，古川賢英，奥井紀光，坂本太郎，後町武志，池上　徹
- Organizer
  第33回日本消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵頭部癌における膵頭十二指腸切除術後最大血小板/リンパ球比が示すがん再発と長期予後2022
- Author(s)
  白井祥睦, 後町武志, 羽村凌雅, 恒松雅, 堀内尭, 奥井紀光, 鈴木文武, 塩崎弘憲, 坂本太郎, 春木孝一郎, 古川賢英, 恩田真二, 大木隆生, 池上徹
- Organizer
  第122 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵臓癌におけるトロンボモジュリンの働き.2022
- Author(s)
  白井祥睦, 後町武志, 羽村凌雅, 恒松雅, 柳垣充, 谷合智彦, 坂本太郎, 堀内尭, 奥井紀光, 塩崎弘憲, 春木孝一郎, 古川賢英, 恩田真二, 柴浩明, 池上徹
- Organizer
  第20回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵癌における酸性βグルコシダーゼ阻害はマイトファジー不全とアポトーシスを誘導する2022
- Author(s)
  柳垣　充，白井祥睦，嶋田洋太，羽村凌雅，谷合智彦，堀内　尭，春木孝一郎，古川賢英，小林博司，池上　徹.
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 腹腔鏡下脾温存膵体尾部切除術における血行動態に着目した手技の工夫2022
- Author(s)
  白井祥睦, 恩田真二, 羽村凌雅, 堀内尭, 恒松雅, 奥井紀光, 坂本太郎, 後町武志, 柳垣充, 丹治芳明, 塩崎弘憲, 安田淳吾, 春木孝一郎, 古川賢英, 池上徹
- Organizer
  第35回日本内視鏡外科学会総会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵癌における酸性βグルコシダーゼ阻害はマイトファジー不全とアポトーシスを誘導する2022
- Author(s)
  柳垣　充，白井祥睦, 嶋田洋太, 羽村凌雅，谷合智彦, 堀内　　尭，春木孝一郎，古川賢英, 小林博司, 池上　徹
- Organizer
  第60回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Methods of laparoscopic extensive distal and central pancreatectomy2022
- Author(s)
  白井祥睦, 後町武志, 恩田真二, 堀内尭, 奥井紀光, 坂本太郎, 羽村凌雅, 柳垣充, 恒松雅,丹治芳明, 谷合智彦, 春木孝一郎, 古川賢英, 池上徹
- Organizer
  第34回日本肝胆膵外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 癌代謝メカニズムに着目し、抗癌剤耐性を改善する2022
- Author(s)
  白井祥睦，後町武志，羽村凌雅，柳垣充，谷合智彦, 丹治芳明, 恒松雅, 奥井紀光, 塩崎弘憲, 坂本太郎, 恩田真二, 池上徹
- Organizer
  第54回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] NF-kB inhibitors suppress pancreatic cancer metastasis by downregulating FSCN1 expression through miR-145a-5p2022
- Author(s)
  Yanagaki M, Shirai Y, Saito N，Hamura R，Taniai T, Tanji Y，Tsunematsu M，Sakamoto T，Ikegami T
- Organizer
  第53回日本膵臓学会大会・第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] NF-kB inhibitors induce FSCN1 expression through miR-145a-5p in pancreatic cancer metastasis2022
- Author(s)
  Yanagaki M, Shirai Y, Saito N, Hamura R, Taniai T, Horiuchi T, Takada N, Tsunematsu M, Gocho T, Ikegami T
- Organizer
  第34回日本肝胆膵外科学会総会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Minimally invasive laparoscopic extensive central and distal pancreatectomy2022
- Author(s)
  Shirai Y, Gocho T, Sakamoto T, Tsunematsu M, Okui N, Hamura R, Tanji Y, Yanagaki M, Horiuchi T, Shiozaki H, Onda S, Ikegami T
- Organizer
  Joint Congress of the 26th Meeting of International Association of Pancreatology and the 53rd Annual Meeting of Japan Pancreas Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Maximum platelet to lymphocyte ratio predicts outcome of pancreaticoduodenectomy in patients with pancreatic head cancer2022
- Author(s)
  白井祥睦, 後町武志, 羽村凌雅, 柳垣充, 坂本太郎, 春木孝一郎, 古川賢英, 恩田真二, 柴浩明, 池上徹
- Organizer
  第77回日本消化器外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Lysosome酵素に着目した革新的治療法の開発　癌代謝メカニズムへの新たなアプローチ2021
- Author(s)
  白井祥睦, 池上徹, 羽村凌雅, 谷合智彦, 柳垣充, 堀内尭, 嶋田洋太, 鐘ヶ江裕美, 坪井一人, 岡本安雄, 後町武志, 大橋十也, 大木隆生
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08718
[Presentation] 膵癌におけるライソゾーム機構の分子機序解明と革新的治療の開発2021
- Author(s)
  羽村凌雅，白井祥睦，谷合智彦，柳垣　充，春木孝一郎，古川賢英，坂本太郎，後町武志，池上　徹．
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 膵癌に対するGPR15を標的とした新規治療法の開発2021
- Author(s)
  古川賢英，春木孝一郎，羽村凌雅，河合裕成，谷合智彦，白井祥睦，柳垣　充，恩田真二，坂本太郎，後町武志，池上　徹．
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 肝細胞癌における切除後全身炎症反応持続の臨床的意義2021
- Author(s)
  春木孝一郎，古川賢英，恩田真二，安田淳吾，羽村凌雅，白井祥睦，恒松　雅，飯田智憲，坂本太郎，谷合智彦，柳垣　充，河合裕成，後町武志，池上　徹．
- Organizer
  第19回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] 膵臓癌に対するセラミド代謝制御による抗腫瘍効果の分子生物学的機序の解明2021
- Author(s)
  谷合智彦，白井祥睦，嶋田洋太，羽村凌雅，柳垣充，古川賢英，春木孝一郎，河合裕成，恩田真二，坂本太郎，後町武志，宇和川匡，島田周，田中真二，池上徹
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵臓癌に対するセラミド代謝制御による抗腫瘍効果の分子生物学的機序の解明2021
- Author(s)
  谷合智彦，白井祥睦，嶋田洋太，羽村凌雅，柳垣　充，古川賢英，春木孝一郎，河合裕成，恩田真二，坂本太郎，後町武志，宇和川　匡，島田　周，田中真二，池上　徹．
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K08805
[Presentation] トロンボモジュリンの抗炎症作用による膵癌進展抑制効果2021
- Author(s)
  白井祥睦, 後町武志, 羽村凌雅, 恒松雅, 堀内尭, 塩崎弘憲, 坂本太郎, 谷合智彦, 柳垣充, 春木孝一郎, 安田淳吾, 古川賢英, 恩田真二, 奥井紀光, 鈴木文武, 阿部恭平, 宇和川匡, 菅野宏, 佐藤峻, 池上徹
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K08718
[Presentation] Gene therapy targeting lysosomal enzymes in pancreatic cancer.2021
- Author(s)
  Shirai Y, Yanagaki M, Hamura R, Taniai T, Ikegami T.
- Organizer
  IASGO-CME Advanced Post-Graduate Course in Ngaasaki 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Lysosome酵素に着目した革新的療法の開発～癌代謝メカニズムへの新たなアプローチ～2021
- Author(s)
  白井祥睦, 池上徹, 羽村凌雅, 谷合智彦, 柳垣充, 堀内尭, 嶋田洋太, 鐘ヶ江裕美, 坪井一人, 岡本安雄, 後町武志, 大橋十也, 大木隆生
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 膵臓癌に対するLysosome酵素制御によるTFEB抑制を介した抗腫瘍効果誘導の試み2021
- Author(s)
  羽村凌雅、白井祥睦、谷合智彦、柳垣充、斉藤庸博、堀内尭、高田直樹、嶋田洋太、鐘ヶ江裕美、大橋十也、矢永勝彦
- Organizer
  第51回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Inhibition of sphingolipid metabolism induces mitophagy and lysosomal dysfunction in pancreatic cancer2021
- Author(s)
  Mitsuru Yanagaki, Yoshihiro Shirai, Ryoga Hamura, Tomohiko Taniai, Yohta Shimada, Takashi Horiuchi, Naoki Takada, Nobuhiro Saito, Toya Ohashi, Toru Ikegami
- Organizer
  The 33rd Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery.
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] 大腸癌肝転移肝切除における外科感染症のリスク因子の検討と長期予後改善を目指した対策2020
- Author(s)
  古川賢英, 後町武志, 谷合智彦, 柳垣充, 羽村凌雅, 堀内尭, 白井祥睦, 安田淳吾, 春木孝一郎, 塩崎弘憲, 恩田真二, 池上徹
- Organizer
  第82回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-18K08647
[Presentation] ライソゾーム酵素による膵臓癌におけるオートファジー調整機構の解明2020
- Author(s)
  羽村凌雅、白井祥睦、谷合智彦、柳垣充、高田直樹、堀内尭、嶋田洋太、鐘ヶ江裕美、大橋十也、池上徹
- Organizer
  第31回消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Inhibition of sphingolipid metabolism has ceramide-induced anti-tumor effect on pancreatic cacner cells2020
- Author(s)
  Tomohiko Taniai, Yoshihiro Shirai, Yohta Shimada, Ryoga Hamura, Mitsuru Yanagaki, Naoki Takada, Kazuhito Tsuboi, Yasuo Okamoto, Toya Ohashi, Katsuhiko Yanaga, Toru Ikegami
- Organizer
  American Collage of Surgeons (ACS) clinical congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] スフィンゴリン脂質代謝に着目した膵臓がんに対する抗腫瘍効果の検討2020
- Author(s)
  谷合智彦、池上徹、矢永勝彦、白井祥睦、柳垣充、羽村凌雅、高田直樹、堀内尭、嶋田洋太、後町武志、柴浩明、大橋十也、大木隆生
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K17665
[Presentation] Down-regulation of acid-α glucosidase induce antitumor effect via mitochondrial dysfunction in pancreatic cancer cell2019
- Author(s)
  Ryoga Hamura, Yoshihiro Shirai, Nobuhiro Saito, Tomohiko Taniai, Yohta Shimada, Takashi Horiuchi, Hiroshi Sugano, Naoki Takada, Yumi Kanegae, Toya Ohashi, Katsuhiko Yanaga
- Organizer
  第78回　日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] Parkin-dependent mitophagy in hepatic ischemia-reperfusion injury2019
- Author(s)
  白井祥睦
- Organizer
  第31回日本肝胆膵外科学会学術集会
- Data Source
  KAKENHI-PROJECT-15K10173
[Presentation] 抗癌剤耐性膵癌におけるライソソーム酵素の機能解析と遺伝子制御による塩酸ゲムシタビンの抗腫瘍効果増強の試み2019
- Author(s)
  羽村凌雅, 矢永勝彦, 白井祥睦, 谷合智彦, 斉藤庸博, 嶋田洋太, 堀内尭, 菅野宏, 高田直樹, 鐘ヶ江裕美, 大橋十也, 大木隆生
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] 抗癌剤耐性膵癌におけるライソソーム酵素の機能解析と遺伝子制御による塩酸ゲムシタビンの抗腫瘍効果増強の試み2019
- Author(s)
  羽村凌雅, 矢永勝彦, 白井祥睦, 谷合智彦, 斉藤庸博, 嶋田洋太, 堀内尭, 菅野宏, 高田直樹, 鐘ヶ江裕美, 大橋十也, 大木隆生.
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] Inhibition of lysosomal enzyme activity enhances antitumor effect of gemcitabine in pancreatic cancer cells.2019
- Author(s)
  Ryoga Hamura, Yoshihiro Shirai, Nobuhiro Saito, Tomohiko Taniai, Yohta Shimada, Takashi Horiuchi, Hiroshi Sugano, Naoki Takada, Yumi Kanegae, Toya Ohashi, Katsuhiko Yanaga
- Organizer
  14th Annual Academic Surgical Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] Inhibition of lysosomal enzyme activity enhances antitumor effect of gemcitabine in pancreatic cancer cells.2019
- Author(s)
  Hamura R, Shirai Y, Saito N, Taniai T, Shimada Y, Horiuchi T, Sugano H, Takada N, Kanegae Y, Ohashi T, Yanaga K.
- Organizer
  14th Annual Academic Surgical Congress (ASC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] Inhibition of acid ceramidase enhances antitumor effect of gemcitabine on pancreatic cancer cells2019
- Author(s)
  Tomohiko Taniai, Yoshihiro Shirai, Ryoga Hamura, Takashi Horiuchi, Nobuhiro Saito, Mitsuru Yanagaki, Yohta Shimada, Naoki Takada, Toya Ohashi, Katsuhiko Yanaga
- Organizer
  第78回　日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16584
[Presentation] Suppression of lysosomal enzyme improves chemoresistance in pancreatic cancer cells.2018
- Author(s)
  Hamura R, Shirai Y, Saito N, Taniai T, Shimada Y, Horiuchi T, Sugano H, Takada N, Kanegae Y, Ohashi T, Yanaga K
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16584

1. Ikegami Toru (80432938)

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35. 鐘ヶ江裕美

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Shirai Yoshihiro 白井 祥睦

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Analysis of lysosome enzymes in pancreatic cancer specific immune evasion systemPrincipal Investigator

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Analysis of lysosomal metabolism in pancreatic cancerPrincipal Investigator

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Analysis of lysosome in pancreatic cancerPrincipal Investigator

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[Journal Article] Effect of Risk Factor Score on Early Recurrence After Pancreatectomy for Invasive Pancreatic Ductal Adenocarcinoma2024

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[Journal Article] The Signal intensity ratio of pancreas to spleen in magnetic resonance imaging can predict non-alcoholic fatty liver disease following pancreaticoduodenectomy2024

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Shirai Yoshihiro 白井祥睦