Higashikawa Kei 東川桂

Researcher Number	10756878
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2019: 北海道大学, アイソトープ総合センター, 助教
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator チミジンホスホリラーゼ / 核医学 / NASH / [123/125I]IIMU / 非アルコール性脂肪肝炎 / メチオニン・コリン欠乏食 / 分子イメージング / 慢性炎症 / 補体 / Ｐｒｏｐｅｒｄｉｎ … More Except Principal Investigator 放射線 / 核医学 / 組織因子 / 癌 / RI内用療法 / 動脈硬化 / 核医学診断 / 不安定プラーク / 低酸素イメージング / マクロファージ / インテグリンαvβ３ / インテグリンαvβ3 / がん / グリオキサラーゼⅠ / 放射性分子プローブ / 質的診断 / 治療効果予測 / 悪性度診断 / 放射性医薬品 / グリオキサラーゼI / PET / 薬剤合成装置 / オン・デマンド / 自己遮蔽型 / ディスポチップ / PET薬剤合成装置 / ディスポ・チップ型 / がんのイメージング / 薬学 / チミジンホスホリラーゼ（TP） / ヨウ素標識IIMU / 核医学診断薬 / SPECTイメージング / 5－フルオロウラシル（5-FU) / プロドラッグ / 抗がん剤Paclitaxel / 担癌モデル動物 / 5-フルオロウラシル（5-FU） / ５－FUプロドラッグ / がんの核医学的分子イメージング / IIMU / ＰＥＴ／ＳＰＥＣＴ / 5-フルオロウラシル / 治療用放射性薬剤 / チミジンホスホリラーゼ / アスタチン / 細胞老化 / 腫瘍 / Id-1 / 質量分析イメージング / プロテオーム / α線治療 / がん免疫 / α線 / 核医学治療 Less

PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivativesOngoing
- Principal Investigator
  
  西嶋剣一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
Development of a MS imaging-based diagnosis for novel cancer senotherapyOngoing
- Principal Investigator
  
  安井博宣
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hokkaido University
α線治療はなぜ効くのか？ーがん免疫から迫るーOngoing
- Principal Investigator
  
  小川美香子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hokkaido University
生検に代わる診断法：NASH鑑別診断を可能とする新規核医学イメージング法の開発Principal Investigator
- Principal Investigator
  
  東川桂
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of an imaging method of complement complex for the diagnosis of chronic inflammatory diseasePrincipal Investigator
- Principal Investigator
  
  Higashikawa Kei
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
A new disposable chip type PET drug synthesizer for on-demand PET examination
- Principal Investigator
  
  KUGE YUJI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Hokkaido University
細胞周期制御因子CDK2を標的とした放射性プローブの開発Ongoing
- Principal Investigator
  
  北浦廣剛
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of a radiolabeled probe to detect a novel target, glyoxalase I, for diagnosing characteristics of cancers
- Principal Investigator
  
  AKIZAWA Hiromichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Showa Pharmaceutical University
Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept
- Principal Investigator
  
  Zhao Songji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration
- Principal Investigator
  
  KUGE YUJI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylasePrincipal Investigator
- Principal Investigator
  
  Higashikawa Kei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis2020
- Author(s)
  Higashikawa Kei、Horiguchi Sawako、Tarisawa Makoto、Shibata Yuki、Ohkura Kazue、Yasui Hironobu、Takeda Hiroshi、Kuge Yuji
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 82-83 Pages: 25-32
- DOI
  10.1016/j.nucmedbio.2019.12.006
- Data Source
  KAKENHI-PROJECT-19K17255
[Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models.2019
- Author(s)
  Zhao Songji、Yu Wenwen、Ukon Naoyuki、Tan Chengbo、Nishijima Ken-ichi、Shimizu Yoichi、Higashikawa Kei、Shiga Tohru、Yamashita Hiroko、Tamaki Nagara、Kuge Yuji
- Journal Title
  
  EJNMMI Research.
  
  Volume: 9 Pages: 51-51
- DOI
  10.1186/s13550-019-0521-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-18H02757
[Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models2019
- Author(s)
  Zhao S, Yu W, Ukon N, Tan C, Nishijima K, Shimizu Y, Higashikawa K, Shiga T, Yamashita H, Tamaki N, Kuge Y.
- Journal Title
  
  EJNMMI Res
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Journal Article] Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO2019
- Author(s)
  Watanabe Shiro、Shiga Tohru、Hirata Kenji、Magota Keiichi、Okamoto Shozo、Toyonaga Takuya、Higashikawa Kei、Yasui Hironobu、Kobayashi Jun、Nishijima Ken-ichi、Iseki Ken、Matsumoto Hiroki、Kuge Yuji、Tamaki Nagara
- Journal Title
  
  EJNMMI Research
  
  Volume: 9 Pages: 60-60
- DOI
  10.1186/s13550-019-0525-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-17K10428
[Journal Article] [18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.2018
- Author(s)
  Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K.
- Journal Title
  
  EJNMMI Res
  
  Volume: 8 Pages: 35-35
- DOI
  10.1186/s13550-018-0392-6
- NAID
  120006482581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] チミジンホスホリラーゼイメージングプローブを用いた非アルコール性脂肪肝炎の鑑別法の開発研究2019
- Author(s)
  東川桂, 上原里穂, 堀口紗和子, 柴田悠貴, 足澤誠, 北浦廣剛, 安井博宣, 武田宏司, 久下裕司
- Organizer
  第14 回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] Investigation of the potentials of a thymidine phosphorylase imaging probe for the differential diagnosis of nonalcoholic steatohepatitis2019
- Author(s)
  Kei Higashikawa, Riho Uehara, Sawako Horiguchi, Yuki Shibata, Makoto Tarisawa, Hirotake Kitaura, Hironobu Yasui, Hiroshi Takeda, Yuji Kuge
- Organizer
  The 23rd International Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] 含水18Ｆ溶液と濃縮18Ｆ化法による18-FMISOの18Ｆ化反応の検討2019
- Author(s)
  阿保憲史，桐生真登，東川桂，志賀哲，久下裕司
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K19640
[Presentation] チミジンホスホリラーゼ標的プローブを非アルコール性脂肪肝炎診断に応用するためのin vivo機能解析2019
- Author(s)
  上原里穂, 東川桂, 堀口紗和子, 足澤誠, 柴田悠貴, 大久保直登, 北浦廣剛, 安井博宣, 久下裕司, 武田宏司
- Organizer
  第3回日本核医学会分科会放射薬品科学研究会/第19回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] チミジンホスホリラーゼ標的核医学イメージングプローブを用いた非侵襲的NASH診断法の開発研究2019
- Author(s)
  東川桂, 上原里穂, 堀口紗和子, 柴田悠貴, 足澤誠, 北浦廣剛, 安井博宣, 武田宏司, 久下裕司
- Organizer
  第72回日本酸化ストレス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17255
[Presentation] チミジンホスホリラーゼイメージングプローブによる非アルコール性脂肪肝炎の診断法の開発研究。2018
- Author(s)
  東川桂、堀口紗和子、足澤誠、小松由紀子、大倉一枝、安井博宣、武田宏司、久下裕司。
- Organizer
  第13回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Potentials of a thymidine phosphorylase imaging agent in the diagnosis of nonalcoholic steatohepatitis.2018
- Author(s)
  Higashikawa K, Horiguchi S, Uehara R, Tarisawa M, Shibata Y, Kitaura H, Yasui H, Takeda H, Kuge Y.
- Organizer
  The Tenth China-Japan-Korea Symposium on Radiopharmaceutical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic　steatohepatitis.2018
- Author(s)
  Higashikawa K, Horiguchi S, Ebita Y, Tarisawa M, Komatsu Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Investigation of the influence of intratumoral glutathione status on the distribution of a hypoxic probe [18F]FMISO.2018
- Author(s)
  Yasui H, Higashikawa K, Shimizu Y, Shibata Y, Zhao S, Matsumoto H, Shiga T, Tamaki N, Kuge Y.
- Organizer
  WFNMB 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] マクロファージの極性化が18F-FMISOと125I-BMIPPの集積に及ぼす影響2017
- Author(s)
  1.本村新，志水陽一，高倉栄男，安井博宣，東川桂，玉木長良，久下裕司，小川美香子
- Organizer
  第1回放射性薬品科学研究会(京都市)
- Data Source
  KAKENHI-PROJECT-26293268
[Presentation] Effect of eribulin on remodeling of tumor vasculature confirmed by FMISO PET imaging-Small-animal PET study in human breast cancer cell xenograft-2017
- Author(s)
  Zhao S, Yu W, Ukon N, Nishijima K, Shimizu Y, Higashikawa K, Yamashita H, Tamaki N, Kuge Y.
- Organizer
  The 64th Society of Nuclear Medicine Annual Meeting in Denver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335

1. KUGE YUJI (70321958)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. 西嶋剣一 (60364254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 志水陽一 (90634212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 大倉一枝 (60094827)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. AKIZAWA Hiromichi (90311795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Zhao Songji (80374239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 志賀哲 (80374495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 川井恵一 (30204663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 浅田祐士郎 (70202588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鐙谷武雄 (80270726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 七戸秀夫 (80374479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山下篤 (90372797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 玉木長良 (30171888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 宿里充穗 (20525571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 尾江悟 (90756107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 木村寛之 (50437240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 北浦廣剛 (10281817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大島伸宏 (80508648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 北川善政 (00224957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 粟生木美穂 (10783227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 安井博宣 (10570228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 稲波修 (10193559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 孫略 (40757704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小川美香子 (20344351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Abo Norifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. OKAMOTO Shouzo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashikawa Kei 東川 桂

Research Projects

Research Products

Co-Researchers

PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivativesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a MS imaging-based diagnosis for novel cancer senotherapyOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

α線治療はなぜ効くのか？ーがん免疫から迫るーOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生検に代わる診断法：NASH鑑別診断を可能とする新規核医学イメージング法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an imaging method of complement complex for the diagnosis of chronic inflammatory diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new disposable chip type PET drug synthesizer for on-demand PET examination

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞周期制御因子CDK2を標的とした放射性プローブの開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a radiolabeled probe to detect a novel target, glyoxalase I, for diagnosing characteristics of cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis2020

Author(s)

Journal Title

DOI

Higashikawa Kei 東川桂

[Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic　steatohepatitis.2018