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Higashikawa Kei  東川 桂

ORCIDConnect your ORCID iD *help
Researcher Number 10756878
Other IDs
Affiliation (based on the past Project Information) *help 2015 – 2019: 北海道大学, アイソトープ総合センター, 助教
Review Section/Research Field
Principal Investigator
Radiation science / Basic Section 52040:Radiological sciences-related
Except Principal Investigator
Radiation science / Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
チミジンホスホリラーゼ / 核医学 / NASH / [123/125I]IIMU / 非アルコール性脂肪肝炎 / メチオニン・コリン欠乏食 / 分子イメージング / 慢性炎症 / 補体 / Properdin … More / 核医学診断薬 / TP / [123I]IIMU / SS … More
Except Principal Investigator
放射線 / 核医学 / 組織因子 / 癌 / RI内用療法 / 動脈硬化 / 核医学診断 / 不安定プラーク / 低酸素イメージング / マクロファージ / インテグリンαvβ3 / インテグリンαvβ3 / がん / グリオキサラーゼⅠ / 放射性分子プローブ / 質的診断 / 治療効果予測 / 悪性度診断 / 放射性医薬品 / グリオキサラーゼI / PET / 薬剤合成装置 / オン・デマンド / 自己遮蔽型 / ディスポチップ / PET薬剤合成装置 / ディスポ・チップ型 / がんのイメージング / 薬学 / チミジンホスホリラーゼ(TP) / ヨウ素標識IIMU / 核医学診断薬 / SPECTイメージング / 5-フルオロウラシル(5-FU) / プロドラッグ / 抗がん剤Paclitaxel / 担癌モデル動物 / 5-フルオロウラシル(5-FU) / 5-FUプロドラッグ / がんの核医学的分子イメージング / IIMU / PET/SPECT / 5-フルオロウラシル / 治療用放射性薬剤 / チミジンホスホリラーゼ / アスタチン / 細胞老化 / 腫瘍 / Id-1 / 質量分析イメージング / プロテオーム / α線治療 / がん免疫 / α線 / 核医学治療 Less
  • Research Projects

    (12 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (26 People)
  •  PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivativesOngoing

    • Principal Investigator
      西嶋 剣一
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Development of a MS imaging-based diagnosis for novel cancer senotherapyOngoing

    • Principal Investigator
      安井 博宣
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Hokkaido University
  •  α線治療はなぜ効くのか?ーがん免疫から迫るーOngoing

    • Principal Investigator
      小川 美香子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Hokkaido University
  •  生検に代わる診断法:NASH鑑別診断を可能とする新規核医学イメージング法の開発Principal Investigator

    • Principal Investigator
      東川 桂
    • Project Period (FY)
      2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Hokkaido University
  •  Development of an imaging method of complement complex for the diagnosis of chronic inflammatory diseasePrincipal Investigator

    • Principal Investigator
      Higashikawa Kei
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  A new disposable chip type PET drug synthesizer for on-demand PET examination

    • Principal Investigator
      KUGE YUJI
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Hokkaido University
  •  細胞周期制御因子CDK2を標的とした放射性プローブの開発Ongoing

    • Principal Investigator
      北浦 廣剛
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Health Sciences University of Hokkaido
  •  Development of a radiolabeled probe to detect a novel target, glyoxalase I, for diagnosing characteristics of cancers

    • Principal Investigator
      AKIZAWA Hiromichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Showa Pharmaceutical University
  •  Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept

    • Principal Investigator
      Zhao Songji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Fukushima Medical University
  •  A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration

    • Principal Investigator
      KUGE YUJI
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylasePrincipal Investigator

    • Principal Investigator
      Higashikawa Kei
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM

    • Principal Investigator
      KUGE Yuji
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University

All 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis2020

    • Author(s)
      Higashikawa Kei、Horiguchi Sawako、Tarisawa Makoto、Shibata Yuki、Ohkura Kazue、Yasui Hironobu、Takeda Hiroshi、Kuge Yuji
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 82-83 Pages: 25-32

    • DOI

      10.1016/j.nucmedbio.2019.12.006

    • Data Source
      KAKENHI-PROJECT-19K17255
  • [Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models.2019

    • Author(s)
      Zhao Songji、Yu Wenwen、Ukon Naoyuki、Tan Chengbo、Nishijima Ken-ichi、Shimizu Yoichi、Higashikawa Kei、Shiga Tohru、Yamashita Hiroko、Tamaki Nagara、Kuge Yuji
    • Journal Title

      EJNMMI Research.

      Volume: 9 Pages: 51-51

    • DOI

      10.1186/s13550-019-0521-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-18H02757
  • [Journal Article] Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models2019

    • Author(s)
      Zhao S, Yu W, Ukon N, Tan C, Nishijima K, Shimizu Y, Higashikawa K, Shiga T, Yamashita H, Tamaki N, Kuge Y.
    • Journal Title

      EJNMMI Res

      Volume: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Journal Article] Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO2019

    • Author(s)
      Watanabe Shiro、Shiga Tohru、Hirata Kenji、Magota Keiichi、Okamoto Shozo、Toyonaga Takuya、Higashikawa Kei、Yasui Hironobu、Kobayashi Jun、Nishijima Ken-ichi、Iseki Ken、Matsumoto Hiroki、Kuge Yuji、Tamaki Nagara
    • Journal Title

      EJNMMI Research

      Volume: 9 Pages: 60-60

    • DOI

      10.1186/s13550-019-0525-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-17K10428
  • [Journal Article] [18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.2018

    • Author(s)
      Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K.
    • Journal Title

      EJNMMI Res

      Volume: 8 Pages: 35-35

    • DOI

      10.1186/s13550-018-0392-6

    • NAID

      120006482581

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Presentation] チミジンホスホリラーゼイメージングプローブを用いた非アルコール性脂肪肝炎の鑑別法の開発研究2019

    • Author(s)
      東川桂, 上原里穂, 堀口紗和子, 柴田悠貴, 足澤誠, 北浦廣剛, 安井博宣, 武田宏司, 久下裕司
    • Organizer
      第14 回日本分子イメージング学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-19K17255
  • [Presentation] Investigation of the potentials of a thymidine phosphorylase imaging probe for the differential diagnosis of nonalcoholic steatohepatitis2019

    • Author(s)
      Kei Higashikawa, Riho Uehara, Sawako Horiguchi, Yuki Shibata, Makoto Tarisawa, Hirotake Kitaura, Hironobu Yasui, Hiroshi Takeda, Yuji Kuge
    • Organizer
      The 23rd International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17255
  • [Presentation] 含水18F溶液と濃縮18F化法による18-FMISOの18F化反応の検討2019

    • Author(s)
      阿保 憲史, 桐生 真登, 東川 桂, 志賀 哲, 久下 裕司
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17K19640
  • [Presentation] チミジンホスホリラーゼ標的プローブを非アルコール性脂肪肝炎診断に応用するためのin vivo機能解析2019

    • Author(s)
      上原里穂, 東川桂, 堀口紗和子, 足澤誠, 柴田悠貴, 大久保直登, 北浦廣剛, 安井博宣, 久下裕司, 武田宏司
    • Organizer
      第3回日本核医学会分科会放射薬品科学研究会/第19回放射性医薬品・画像診断薬研究会
    • Data Source
      KAKENHI-PROJECT-19K17255
  • [Presentation] チミジンホスホリラーゼ標的核医学イメージングプローブを用いた非侵襲的NASH診断法の開発研究2019

    • Author(s)
      東川 桂, 上原 里穂, 堀口 紗和子, 柴田 悠貴, 足澤 誠, 北浦 廣剛, 安井 博宣, 武田 宏司, 久下 裕司
    • Organizer
      第72回 日本酸化ストレス学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K17255
  • [Presentation] チミジンホスホリラーゼイメージングプローブによる非アルコール性脂肪肝炎の診断法の開発研究。2018

    • Author(s)
      東川 桂、堀口 紗和子、足澤 誠、小松由紀子、大倉一枝、安井 博宣、武田 宏司、久下 裕司。
    • Organizer
      第13回日本分子イメージング学会
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Presentation] Potentials of a thymidine phosphorylase imaging agent in the diagnosis of nonalcoholic steatohepatitis.2018

    • Author(s)
      Higashikawa K, Horiguchi S, Uehara R, Tarisawa M, Shibata Y, Kitaura H, Yasui H, Takeda H, Kuge Y.
    • Organizer
      The Tenth China-Japan-Korea Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic steatohepatitis.2018

    • Author(s)
      Higashikawa K, Horiguchi S, Ebita Y, Tarisawa M, Komatsu Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Presentation] Investigation of the influence of intratumoral glutathione status on the distribution of a hypoxic probe [18F]FMISO.2018

    • Author(s)
      Yasui H, Higashikawa K, Shimizu Y, Shibata Y, Zhao S, Matsumoto H, Shiga T, Tamaki N, Kuge Y.
    • Organizer
      WFNMB 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • [Presentation] マクロファージの極性化が18F-FMISOと125I-BMIPPの集積に及ぼす影響2017

    • Author(s)
      1.本村新,志水陽一,高倉栄男,安井博宣,東川桂,玉木長良,久下裕司,小川美香子
    • Organizer
      第1回放射性薬品科学研究会(京都市)
    • Data Source
      KAKENHI-PROJECT-26293268
  • [Presentation] Effect of eribulin on remodeling of tumor vasculature confirmed by FMISO PET imaging-Small-animal PET study in human breast cancer cell xenograft-2017

    • Author(s)
      Zhao S, Yu W, Ukon N, Nishijima K, Shimizu Y, Higashikawa K, Yamashita H, Tamaki N, Kuge Y.
    • Organizer
      The 64th Society of Nuclear Medicine Annual Meeting in Denver
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10335
  • 1.  KUGE YUJI (70321958)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 2.  西嶋 剣一 (60364254)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  志水 陽一 (90634212)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 4.  大倉 一枝 (60094827)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  AKIZAWA Hiromichi (90311795)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Zhao Songji (80374239)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 7.  志賀 哲 (80374495)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 8.  川井 恵一 (30204663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  浅田 祐士郎 (70202588)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  鐙谷 武雄 (80270726)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  七戸 秀夫 (80374479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  山下 篤 (90372797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  玉木 長良 (30171888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  宿里 充穗 (20525571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  尾江 悟 (90756107)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  木村 寛之 (50437240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  北浦 廣剛 (10281817)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  大島 伸宏 (80508648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  北川 善政 (00224957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  粟生木 美穂 (10783227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  安井 博宣 (10570228)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  稲波 修 (10193559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  孫 略 (40757704)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  小川 美香子 (20344351)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  Abo Norifumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  OKAMOTO Shouzo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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