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HIRAOKA Yukihiro  平岡 行博

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… Alternative Names

平岡 行博  ヒラオカ ユキヒロ

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Researcher Number 20097512
Other IDs
External Links
Affiliation (Current) 2022: 松本歯科大学, 総合歯科医学研究所, 教授
Affiliation (based on the past Project Information) *help 2014 – 2016: 松本歯科大学, 総合歯科医学研究所, 教授
2007: Matsumoto Dental University, Graduate School, Professor
2006: 松本歯科大学, 大学院歯学独立研究科, 教授
2003 – 2005: Matsumoto Dental University, Graduate School of Oral medicine, Hard Tissue Research, Professor, 大学院・歯学独立研究科, 教授
2002: Institute of Oral Science, Calcified Tissue Research, Professor, 総合歯科医学研究所, 教授 … More
2001: Biochemistry, Associate Professor, 歯学部, 助教授
2000 – 2001: 松本歯科大学, 歯学部, 講師
1995: 松本歯科大学, 歯学部, 講師
1986: 松本歯科大学, 歯学部, 講師 Less
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Applied health science / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Biological Sciences / Functional basic dentistry / Orthodontic/Pediatric dentistry
Keywords
Principal Investigator
SOD / 部位特異的変異 / Porphyromonas gingivalis / スーパーオキシドジスムターゼ / 金属酵素 / 金属選択性 / Porphyromanas gingivalis / 活性酸素 / 酸化還元酵素 / Reactive oxygen … More / Metallo enzyme / Oxidoreductase / 歯周病原菌 / 金属寛容性 / 酵素 / Porhyromonas gingivalis / Superoxyde dismutase / Metal-specific activity / Site-directed mutagenesis / cambialistic / cambialistic enzyme / site-directed mutagenesis / EPR spectrum … More
Except Principal Investigator
破骨細胞 / RANKL / 骨芽細胞 / リポ多糖 / IL-1 / MyD88 / マクロファージ / BMP / ビスフォスフォネート / 骨形成 / 骨吸収 / Smad / アルカリフォスファターゼ / OPG / 骨髄マクロファージ / 炎症性サイトカイン / p38MAPキナーゼ / Osteoclasts / Osteoblast / Lipopolysaccharide / 骨代謝共役 / オステオプロテゲリン / LPS / TRIF / TRAM / IL-6 / IL-17 / T cell / MMP-1 / PGE_2 / ヒトCD14陽性細胞 / TAK1 / 破骨細胞形成抑制因子 / RAW264細胞 / ムラミルジペプチド / Nod2 / 骨粗鬆症治療薬 / p38MAPK / SaOS-4 / 3細胞 / カルシウム / PKC / M-CSF / シグナル伝達 / カップリングファクター / プロリン含有ペプチド / 尿細管 / ミクロビリ画分 / 高速液体クロマトグラフ / ジペプチジルペプチダーゼ【IV】 / アミノペプチダーゼP / Macrophage / Inflammatory cytokine / p38 MAP kinase / ERK / 骨誘導因子 / TNF / Lipopeptide / Toll-like receptor / ビスフォスホネート / 可溶性RANKL / 異所性骨形成 / 骨髄間質細胞 / 骨代謝共役因子 / サイトカイン / Osteoprotegerin (OPG) / Osteoclast / Receptor activator of NF-κB (RANKL) / Bisphosphonate / Coupling / soluble RANKL / ectonic bone formation / マウス / 自然免疫 / TLR4 / bone marrow macrophage / mouse / PDL / メカニカルストレス / periodontal ligament cell / mechanical stress Less
  • Research Projects

    (13 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (20 People)
  •  Development of antibacterial agents of periodontal pathogens : a basic studyPrincipal Investigator

    • Principal Investigator
      HIRAOKA Yukihiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied health science
    • Research Institution
      Matsumoto Dental University
  •  Mechanical stress-generated expression of MMPs in human PDL cell

    • Principal Investigator
      UEMATSU Setsuko
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Osaka University
      Matsumoto Dental University
  •  A change of the metal-specific active site structure of superoxide dismutase from Porphyromonas gingivalis by the mutation of Gly155Thr.Principal Investigator

    • Principal Investigator
      HIRAOKA B.Yukihiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  Signal transduction of RANK and Toll-like receptor in alveolar bone destruction

    • Principal Investigator
      UDAGAWA Nobuyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  In vitro evolution of SOD by DNA shufihingPrincipal Investigator

    • Principal Investigator
      HIRAOKA B.yukihiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  骨芽細胞及びリンパ球の分化を促進する破骨細胞由来新規サイトカインの同定

    • Principal Investigator
      宇田川 信之
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
      Showa University
  •  Analysis of signal transduction of osteoclast differentiation factor (RANKL) in alveolar bone destruction

    • Principal Investigator
      UDAGAWA Nobuyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  Study on mechanism of the coupling between bone resorption and bone formation

    • Principal Investigator
      TAKAHASHI Naoyuki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  破骨細胞を調節するシグナル伝達系と骨・歯周疾患における骨破壊機序の解明

    • Principal Investigator
      TAKAHASHI Naoyuki
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Matsumoto Dental University
      Showa University
  •  Analysis of signal transduction of inflammatory cytokines in bone destruction

    • Principal Investigator
      TAKAHASHI Naoyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      MATSUMOTO DENTAL UNIVERSITY
      Showa University
  •  Structure of P. gingivalis SOD analyzed by mutagenesis and molecular evolutionPrincipal Investigator

    • Principal Investigator
      HIRAOKA B.yukihiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  P-gingivalisスーパーオキシドジスムターゼの部位特異的変異導入Principal Investigator

    • Principal Investigator
      平岡 行博
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  糸球体と尿細管におけるプロリン含有ペプチドの加水分解過程の比較

    • Principal Investigator
      原田 実
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University

All 2014

All Journal Article

  • [Journal Article] Contribution of the amino acid residues located near the active site metal to the metal-specific activity of Porphyromonas gingivalis SOD induced by a double mutation of Leu72Trp and Leu76Phe.2014

    • Author(s)
      Masashi Mihara, Miho Komachiya, Shinya Mizoue , Masaki Osawa, Setsuko Uematsu, Yuichiro Kikuchi, Yuichiro Okubo, Kaname Hirai, Akihiro Kuroiwa, Kazuhiro Yamada, Fumiyuki Yamakura and B.Yukihiro Hiraoka
    • Journal Title

      松本歯学

      Volume: 40 Pages: 26-34

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26560405
  • [Journal Article] Effect of substituting Trp for Leu at position 72 on the structure of Porphyromonas gingivalis superoxide dismutase.2014

    • Author(s)
      Miho Komachiya, Shinya Mizoue , Masashi Mihara, Masaki Osawa, Yuichiro Kikuchi, Setsuko Uematsu, Kaname Hirai, Yuichiro Okubo, Akihiro Kuroiwa, Kazuhiro Yamada, Fumiyuki Yamakura and B.Yukihiro Hiraoka
    • Journal Title

      松本歯学

      Volume: 40 Pages: 19-25

    • NAID

      120005487655

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26560405
  • 1.  UDAGAWA Nobuyuki (70245801)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  TAKAHASHI Naoyuki (90119222)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  MIZOGUCHI Toshihide (90329475)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  OKUMURA Higeki (80350825)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  OZAWA Hidehiro (60018413)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KOBAYASHI Yasuhiro (20264252)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMASHITA Teruhito (90302893)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SASAKI Takahisa (50129839)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  中村 美どり (90278177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  片桐 岳信 (80245802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  自見 英治郎 (40276598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  中道 裕子 (20350829)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  原田 実 (70064657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  茂木 眞希雄 (00174334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  深沢 加代子 (60064698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FURUSAWA Kiyofumi (90165481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  UEMATSU Setsuko (80271378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  UEMATSU Takashi (40203476)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  USUI Yohei (00387424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  大嶋 嘉久 (70340057)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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