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HIRAOKA Yukihiro
平岡 行博
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Alternative Names
平岡 行博 ヒラオカ ユキヒロ
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Researcher Number
20097512
Other IDs
External Links
Affiliation (Current)
2022: 松本歯科大学, 総合歯科医学研究所, 教授
Affiliation (based on the past Project Information)
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2014 – 2016: 松本歯科大学, 総合歯科医学研究所, 教授
2007: Matsumoto Dental University, Graduate School, Professor
2006: 松本歯科大学, 大学院歯学独立研究科, 教授
2003 – 2005: Matsumoto Dental University, Graduate School of Oral medicine, Hard Tissue Research, Professor, 大学院・歯学独立研究科, 教授
2002: Institute of Oral Science, Calcified Tissue Research, Professor, 総合歯科医学研究所, 教授
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2001: Biochemistry, Associate Professor, 歯学部, 助教授
2000 – 2001: 松本歯科大学, 歯学部, 講師
1995: 松本歯科大学, 歯学部, 講師
1986: 松本歯科大学, 歯学部, 講師
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Review Section/Research Field
Principal Investigator
Functional basic dentistry
/
Applied health science
/
Functional basic dentistry
Except Principal Investigator
Functional basic dentistry
/
Biological Sciences
/
Functional basic dentistry
/
Orthodontic/Pediatric dentistry
Keywords
Principal Investigator
SOD / 部位特異的変異 / Porphyromonas gingivalis / スーパーオキシドジスムターゼ / 金属酵素 / 金属選択性 / Porphyromanas gingivalis / 活性酸素 / 酸化還元酵素 / Reactive oxygen
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/ Metallo enzyme / Oxidoreductase / 歯周病原菌 / 金属寛容性 / 酵素 / Porhyromonas gingivalis / Superoxyde dismutase / Metal-specific activity / Site-directed mutagenesis / cambialistic / cambialistic enzyme / site-directed mutagenesis / EPR spectrum
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More
Except Principal Investigator
破骨細胞 / RANKL / 骨芽細胞 / リポ多糖 / IL-1 / MyD88 / マクロファージ / BMP / ビスフォスフォネート / 骨形成 / 骨吸収 / Smad / アルカリフォスファターゼ / OPG / 骨髄マクロファージ / 炎症性サイトカイン / p38MAPキナーゼ / Osteoclasts / Osteoblast / Lipopolysaccharide / 骨代謝共役 / オステオプロテゲリン / LPS / TRIF / TRAM / IL-6 / IL-17 / T cell / MMP-1 / PGE_2 / ヒトCD14陽性細胞 / TAK1 / 破骨細胞形成抑制因子 / RAW264細胞 / ムラミルジペプチド / Nod2 / 骨粗鬆症治療薬 / p38MAPK / SaOS-4 / 3細胞 / カルシウム / PKC / M-CSF / シグナル伝達 / カップリングファクター / プロリン含有ペプチド / 尿細管 / ミクロビリ画分 / 高速液体クロマトグラフ / ジペプチジルペプチダーゼ【IV】 / アミノペプチダーゼP / Macrophage / Inflammatory cytokine / p38 MAP kinase / ERK / 骨誘導因子 / TNF / Lipopeptide / Toll-like receptor / ビスフォスホネート / 可溶性RANKL / 異所性骨形成 / 骨髄間質細胞 / 骨代謝共役因子 / サイトカイン / Osteoprotegerin (OPG) / Osteoclast / Receptor activator of NF-κB (RANKL) / Bisphosphonate / Coupling / soluble RANKL / ectonic bone formation / マウス / 自然免疫 / TLR4 / bone marrow macrophage / mouse / PDL / メカニカルストレス / periodontal ligament cell / mechanical stress
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Research Projects
(
13
results)
Research Products
(
2
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Development of antibacterial agents of periodontal pathogens : a basic study
Principal Investigator
Principal Investigator
HIRAOKA Yukihiro
Project Period (FY)
2014 – 2016
Research Category
Grant-in-Aid for Challenging Exploratory Research
Research Field
Applied health science
Research Institution
Matsumoto Dental University
Mechanical stress-generated expression of MMPs in human PDL cell
Principal Investigator
UEMATSU Setsuko
Project Period (FY)
2005 – 2007
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Orthodontic/Pediatric dentistry
Research Institution
Osaka University
Matsumoto Dental University
A change of the metal-specific active site structure of superoxide dismutase from Porphyromonas gingivalis by the mutation of Gly155Thr.
Principal Investigator
Principal Investigator
HIRAOKA B.Yukihiro
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
Signal transduction of RANK and Toll-like receptor in alveolar bone destruction
Principal Investigator
UDAGAWA Nobuyuki
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
In vitro evolution of SOD by DNA shufihing
Principal Investigator
Principal Investigator
HIRAOKA B.yukihiro
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
骨芽細胞及びリンパ球の分化を促進する破骨細胞由来新規サイトカインの同定
Principal Investigator
宇田川 信之
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
Showa University
Analysis of signal transduction of osteoclast differentiation factor (RANKL) in alveolar bone destruction
Principal Investigator
UDAGAWA Nobuyuki
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
Study on mechanism of the coupling between bone resorption and bone formation
Principal Investigator
TAKAHASHI Naoyuki
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
破骨細胞を調節するシグナル伝達系と骨・歯周疾患における骨破壊機序の解明
Principal Investigator
TAKAHASHI Naoyuki
Project Period (FY)
2000 – 2004
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Biological Sciences
Research Institution
Matsumoto Dental University
Showa University
Analysis of signal transduction of inflammatory cytokines in bone destruction
Principal Investigator
TAKAHASHI Naoyuki
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
MATSUMOTO DENTAL UNIVERSITY
Showa University
Structure of P. gingivalis SOD analyzed by mutagenesis and molecular evolution
Principal Investigator
Principal Investigator
HIRAOKA B.yukihiro
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
P-gingivalisスーパーオキシドジスムターゼの部位特異的変異導入
Principal Investigator
Principal Investigator
平岡 行博
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
糸球体と尿細管におけるプロリン含有ペプチドの加水分解過程の比較
Principal Investigator
原田 実
Project Period (FY)
1986
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Matsumoto Dental University
All
2014
All
Journal Article
[Journal Article] Contribution of the amino acid residues located near the active site metal to the metal-specific activity of Porphyromonas gingivalis SOD induced by a double mutation of Leu72Trp and Leu76Phe.
2014
Author(s)
Masashi Mihara, Miho Komachiya, Shinya Mizoue , Masaki Osawa, Setsuko Uematsu, Yuichiro Kikuchi, Yuichiro Okubo, Kaname Hirai, Akihiro Kuroiwa, Kazuhiro Yamada, Fumiyuki Yamakura and B.Yukihiro Hiraoka
Journal Title
松本歯学
Volume
: 40
Pages
: 26-34
Peer Reviewed / Open Access
Data Source
KAKENHI-PROJECT-26560405
[Journal Article] Effect of substituting Trp for Leu at position 72 on the structure of Porphyromonas gingivalis superoxide dismutase.
2014
Author(s)
Miho Komachiya, Shinya Mizoue , Masashi Mihara, Masaki Osawa, Yuichiro Kikuchi, Setsuko Uematsu, Kaname Hirai, Yuichiro Okubo, Akihiro Kuroiwa, Kazuhiro Yamada, Fumiyuki Yamakura and B.Yukihiro Hiraoka
Journal Title
松本歯学
Volume
: 40
Pages
: 19-25
NAID
120005487655
Peer Reviewed / Open Access
Data Source
KAKENHI-PROJECT-26560405
# of Projects (Dsc)
# of Projects (Asc)
1.
UDAGAWA Nobuyuki
(70245801)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
2.
TAKAHASHI Naoyuki
(90119222)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
3.
MIZOGUCHI Toshihide
(90329475)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
OKUMURA Higeki
(80350825)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
OZAWA Hidehiro
(60018413)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
KOBAYASHI Yasuhiro
(20264252)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
YAMASHITA Teruhito
(90302893)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
SASAKI Takahisa
(50129839)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
中村 美どり
(90278177)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
片桐 岳信
(80245802)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
自見 英治郎
(40276598)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
中道 裕子
(20350829)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
原田 実
(70064657)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
茂木 眞希雄
(00174334)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
深沢 加代子
(60064698)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
FURUSAWA Kiyofumi
(90165481)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
UEMATSU Setsuko
(80271378)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
UEMATSU Takashi
(40203476)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
USUI Yohei
(00387424)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
大嶋 嘉久
(70340057)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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