KUWANO Ryozo 桑野良三

Researcher Number	20111734
Other IDs
External Links
Affiliation (Current)	2021: 社会福祉法人旭川荘(総合研究所特別研究部門), 特別研究部門, 研究員
Affiliation (based on the past Project Information) *help	2013 – 2017: 新潟大学, 脳研究所, フェロー 2007 – 2013: Niigata University, 脳研究所, 教授 2008: 新潟大学, 附属生命科学リソース脳研究所研究センター, 教授 2008: 新潟大学脳研究所, 附属生命科学リソース研究センター, 教授 2007 – 2008: 新潟大学, 脳研究所, 准教授 … More
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Medical genome science / Neurology / 分子細胞生物学 / Laboratory animal science / Medical genome science / Psychiatric science / Cerebral neurosurgery Except Principal Investigator Neurology … More
Keywords	Principal Investigator 遺伝子発現 / 遺伝子 / 免疫組織化学 / アルツハイマー病 / 脳組織 / Cre-lox / S100蛋白 / ジーントラップ / ゲノム / immunohistochemistry … More Except Principal Investigator 遺伝子 / ゲノム / TDP-43 / 転写 / アルツハイマー病 / 筋萎縮性側索硬化症 / 発現制御 / ニューロン / グリア細胞 / プロモーター / 免疫グロブリン遺伝子 / 脳神経疾患 / gene / 神経変性疾患 / 神経疾患 / ChIP-seq / ALS / 制御因子蛋白 / エンハンサー / ゲルシフト分析 / 非ホジキンリンパ腫 / がん抑制遺伝子 / PLEKHA5 / リボソーム受容体 / 粗面小胞体 / 蛋白質の輸送機構 / 膜透過機構 / ラット肝臓 / 分泌蛋白質の生合成 / コクサッキーアデノウイルス受容体 / 心筋炎 / 新生内膜 / 細胞間接着 / CAR / 心筋障害 / 細胞間結合 / malignant lymphoma / brain / in situ hybridization / 脳原発リンパ腫 / ミオシンV / SNARE機構 / 開口放出 / 原子間力顕微鏡 / プロテオミクス / 成長円錐 / シンタキシン / DNAシーケンシング / トランスクリプトーム / ヒト多型タイピング / データベース / 生体生命情報学 / 進化 / 微生物 / 疾患遺伝子 / シグナル伝達 / 神経科学 / 脳神経学 / 脳神経疾愚 / てんかん / 個別化治療 / Epilepsy / polymorohism / CYP / ion channel / receptor / treatment / transporter / 遺伝子タイピング / ゲノム医学研究 / インフォームド・コンセント / 履行補助者 / 匿名化 / ヒト試料 / 多施設共同研究 / 多型 / 多因子疾患 / 単一遺伝病 / SNP / マイクロサテライト / 相関解析 / 研究支援 / 多因子病 / 心筋梗塞 / 多系統委縮症 / 連鎖解析 / 遺伝子多型 / タイピング / 医薬生物統計 / 疾患感受性遺伝子 / 症例-対照関連解析 / 多段階関連解析法 / Replication-based analysis / Joint analysis / 統計学的検出力 / 陽性反応適中度 / 遺伝子解析 / シミュレーション / 紀伊半島 / パーキンソン認知症複合 / アルツハイマー神経原線維変化 / 酸化ストレス / タウ蛋白 / タウオパチー / 認知症 / パーキンソン症候群 / グアム島 / 臨床病理 / 免疫組織化学 / 封入体 / 分子病理 / 分子生物学 / 人口呼吸 / 封人体 / 遺伝子コピー数 / 遺伝性神経疾患 / 遺伝子同定 / ゲノムワイド解析 / 候補遺伝子アプローチ / 遺伝性精神疾患 / 次世代DNAシーケンサー / RNA-seq / de novo配列決定 / 個人ゲノム / リシーケンシング / GWAS / インフォームドコンセント / 次世代DNAシーケンサ / GEM / U12 snRNA / SMN / 核内小体 / Cajal小体 / 転写制御 / クロマチン / 神経病理学 / TDPー４３ / スプライシング / ナンセンス / mRNA分解機構 / 欠損マウス / ミニジーン / スプライシング因子 / 酵素 / 発生・分化 / 発生 / 分化 / 核内高次構造 / クロマチン構造 / ポストGWAS / コピー数変異 / マイクロアレイ / コピー数多型 / シアリダーゼ / cDNA / クローニング / RNA / エノラーゼ / エクソン / イントロン / DNA / 調節因子蛋白 / 微量分析 / 悪性リンパ腫 / 脳腫瘍 / 免疫グロブリン / 遺伝子再構成 / p53遺伝子 / Malignant Lymphoma / Brain Tumor / Non-Hodgkin Lymphoma / Immunoglobulin / Cene Rearrangement / Tumor Suppressor Gene / β_2-ミクログロブリン / 透析アミロイドーシス / トランスジェニックマウス / 血液透析 / マイクロインジェクション / beta2-microglobulin / dialysis-related amyloidosis / transgenic mouse / hemodialysis / microinjection / 脳リンパ種 / p14遺伝子 / p16遺伝子 / 脳リンパ腫 / Brain lymphoma / non-Hodgikin Lymphoma / Tumor suppressor gene / p14 gene / p16 gene / Immunoglobulin gene / 知的障害 / 常染色体劣性 / 伴性劣性 / 脳萎縮 / 重度知的障害 / Xq28 / 伴性劣性遺伝 / 常染色体劣性遺伝 / PEPP2 / mental retardation / autosomal recessive / X-linked recessive / brain atrophy Less

Identification of microRNA editing related to the brains with Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Kuwano Ryozo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Niigata University
Molecular analysis of the differentially expressed miRNA related to progression of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Kuwano Ryozo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Niigata University
Copy number variation database of Alzheimer's disease for genome analysis
- Principal Investigator
  
  Nakaya Akihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Osaka University
  Niigata University
Identification of target molecules related the progression of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  Niigata University
chromosome conformation capture variant technique for disease risk genomic loci
- Principal Investigator
  
  HASEGAWA Mai
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Niigata University
ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?
- Principal Investigator
  
  HITOSHI Takahashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Roles of type II DNA topoisomerase in the interaction of distant genomic sites
- Principal Investigator
  
  TSUTSUI KEN
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Okayama University
Personal genome analysis on Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
Platform of large scale and high quality genomics and bioinformatics: Towards the advancement of genome sciences in academia
- Principal Investigator
  
  KOHARA Yuji
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  National Institute of Genetics
Molecular pathogenesis of ALS: approach from TDP-43 function.
- Principal Investigator
  
  NISHIZAWA Masatoyo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Functional analysis of chromatin dynamics during aging by genomic approach
- Principal Investigator
  
  SAKAI Akiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Niigata University
  Tokyo Institute of Technology
Mutations associated with copy number variation in neurological disorders
- Principal Investigator
  
  IKEUCHI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Neurology
  基礎ゲノム科学
- Research Institution
  Niigata University
Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism
- Principal Investigator
  
  TAKAHASHI Hitoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Statistical genetics for designing multistage genome-wide association studies to detect genetic risk factors
- Principal Investigator
  
  AKAZAWA Kohei
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Statistical science
- Research Institution
  Niigata University
Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan
- Principal Investigator
  
  KUZUHARA Shigeki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
  Mie University
Genome medical research supporting committee
- Principal Investigator
  
  HATA Akira
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Genotyping and its use for brain diseasesPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Niigata University
Support of genotyping to identify genes involved in human diseases
- Principal Investigator
  
  YAMAMOTO Ken
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Comprehensive genomics towards the frontiers of biology and med
- Principal Investigator
  
  KOHARA Yuji
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Genetics
Analysis of molecular biology of epilepsy
- Principal Investigator
  
  KANEKO Sunao
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Neurology
- Research Institution
  Hirosaki University
Isolation and characterization of the new genes isolated from three diseases presenting with severe psychomotor retardation.
- Principal Investigator
  
  WAKAMATSU Nobuaki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
脳原発悪性リンパ腫の患者血液中の腫瘍細胞の同定とその意義
- Principal Investigator
  
  WASHIYAMA Kazuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Niigata University
成長円錐退縮の分子機構における逆行性モーター分子の原子間力顕微鏡を用いた役割解析
- Principal Investigator
  
  五十嵐道弘
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
アンチセンス転写で形質発現に破綻をきたすダブルジーントラップマウスの開発Principal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Niigata University
Identification of immature cells in the adult mouse brainPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  NIIGATA UNIVERSITY
胎生時に発現し心筋傷害時に再び出現するCARの働きと意義
- Principal Investigator
  
  相澤義房
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Niigata University
mRNAの軸索輸送と神経成長円錐での蛋白合成Principal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Primary brain lymphoma : Analysis of tumor suppressor genes and immunoglobulin genes.
- Principal Investigator
  
  KUMANISHI Toshiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Niigata University
The role of astrocytes in maintaing reuronal functionPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
A gene trap approach to identify a new gene involved in central nervous system developmentPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Niigata University
DEVELOPMENT OF MODEL MOUSE FOR DIALYSIS-RELATED AMYLOIDOSIS AND ITS APPLICATION FOR THE ANALYSIS OF PATHOGENESIS.
- Principal Investigator
  
  GEJYO Fumitake
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  FUKUI MEDICAL SCHOOL
A gene trap approach to identify a new gene involved in central nervous system developmentPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
小胞体膜リボソーム受容体の同定と機能
- Principal Investigator
  
  市村徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
MAGmRNAのスプライシング異常はニューロンとグリアとの接着を阻害するかPrincipal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子細胞生物学
- Research Institution
  Niigata University
Primary brain lymphoma : analysis of gene alteration
- Principal Investigator
  
  KUMANISHI Toshiro
- Project Period (FY)
  1991 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Niigata University
脳特異蛋白遺伝子に働く細胞特異的転写制御因子の解析Principal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
Analysis of human D2 dopamine receptor gene in schizophreniaPrincipal Investigator
- Principal Investigator
  
  KUWANO Ryozo, 薄井宏
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Niigata University
アルツハイマ-病(ダウン症候群を含む)に関する遺伝子解析の研究Principal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
ニュ-ロン及びグリアに局在する機能蛋白の遺伝子発現調節蛋白の分離と超微量分析Principal Investigator
- Principal Investigator
  
  桑野良三
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
ニューロン及びグリア細胞における細胞特異蛋白遺伝子の転写制御機構の研究
- Principal Investigator
  
  高橋康夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
ニューロン及びグリアに局在する機能蛋白質の遺伝子発現調節蛋白の分離と超微量分析
- Principal Investigator
  
  高橋康夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
ニューロン及びグリア細胞における細胞特量蛋白遺伝子の転写制御機構の研究
- Principal Investigator
  
  高橋康夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Niigata University
シアリドーシスの遺伝子解析的研究
- Principal Investigator
  
  高橋康夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Niigata University
中枢神経系細胞におけるエノラーゼアイソザイム発現の遺伝的制御
- Principal Investigator
  
  高橋康夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Niigata University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials2018
- Author(s)
  Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative
- Journal Title
  
  Alzheimer's & Dementia
  
  Volume: S1552-5260 Pages: 1077-1087
- DOI
  10.1016/j.jalz.2018.03.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14649, KAKENHI-PROJECT-17K09794, KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-17H04193
[Journal Article] Transethnic genome-wide scan identifies novel Alzheimer's disease loci.2017
- Author(s)
  Jun GR, Kuwano R　(51人中28番目）
- Journal Title
  
  Alzheimers Dement
  
  Volume: 13 Pages: 1-12
- DOI
  10.1016/j.jalz.2016.12.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14649
[Journal Article] Sample Size Estimation for Alzheimer's Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging2017
- Author(s)
  Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, Matsuda H; Japanese Alzheimer’s Disease Neuroimaging Initiative (ADNI).
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 56 Pages: 75-88
- DOI
  10.3233/jad-160621
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K14649
[Journal Article] Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex.2017
- Author(s)
  Sakai Akiko、Nakato Ryuichiro、Ling Yiwei、Hou Xubin、Hara Norikazu、Iijima Tomoya、Yanagawa Yuchio、Kuwano Ryozo、Okuda Shujiro、Shirahige Katsuhiko、Sugiyama Sayaka
- Journal Title
  
  Front Neurosci.
  
  Volume: 11 Pages: 1-15
- DOI
  10.3389/fnins.2017.00307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14781, KAKENHI-PUBLICLY-17H05942, KAKENHI-PROJECT-15H02369, KAKENHI-PROJECT-16H06811, KAKENHI-PROJECT-16K14649
[Journal Article] Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer's diseasc.2017
- Author(s)
  Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikeuchi T, Kuwano R.
- Journal Title
  
  Acta Ncuropathol Commun
  
  Volume: 5 Issue: 1 Pages: 10-10
- DOI
  10.1186/s40478-017-0414-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14649, KAKENHI-PROJECT-16H06277
[Journal Article] Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer's Disease.2016
- Author(s)
  Kikuchi M, Ogishima S, Mizuno S, Miyashita A, Kuwano R, Nakaya J, Tanaka H.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1303 Pages: 479-491
- DOI
  10.1007/978-1-4939-2627-5_29
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25330333, KAKENHI-PROJECT-26640122, KAKENHI-PROJECT-26240044
[Journal Article] AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer's Disease Pathogenesis.2016
- Author(s)
  Ogishima S, Mizuno S, Kikuchi M, Miyashita A, Kuwano R, Tanaka H, Nakaya J.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1303 Pages: 423-32
- DOI
  10.1007/978-1-4939-2627-5_25
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25330333, KAKENHI-PROJECT-26640122, KAKENHI-PROJECT-26240044
[Journal Article] A Second Pedigree with Amyloid-less Familial Alzheimer's Disease Harboring an Identical Mutation in the <i>Amyloid Precursor Protein</i> Gene (E693delta)2015
- Author(s)
  Kutoku Y　ほか
- Journal Title
  
  Internal Medicine
  
  Volume: Epub Issue: 2 Pages: 205-208
- DOI
  10.2169/internalmedicine.54.3021
- NAID
  130004903009
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-24591281, KAKENHI-PROJECT-26640122, KAKENHI-PROJECT-25290018
[Journal Article] HAP2/GCS1 Is Involved in the Sexual Reproduction System of the Marine Macroalga<i> Ulva compressa</i> (Ulvales, Chlorophyta)2015
- Author(s)
  Yamazaki, T., Endo, M., Ito, K., Suzuki, R., Ota, S., Kuwano, K., Miyamura, S., Toyoda, A. and Kawano, S.
- Journal Title
  
  CYTOLOGIA
  
  Volume: 79 Issue: 4 Pages: 575-584
- DOI
  10.1508/cytologia.79.575
- NAID
  130004801645
- ISSN
  0011-4545, 1348-7019
- Year and Date
  2015-01-16
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24657046, KAKENHI-PROJECT-25291070, KAKENHI-PROJECT-25840135, KAKENHI-PROJECT-221S0002
[Journal Article] A Polymorphism in CCR1/CCR3 Is Associated with Narcolepsy2015
- Author(s)
  Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Kawamura Y, Otowa T, Miyashita A,　Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K
- Journal Title
  
  Brain Behav. Immun.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0002
[Journal Article] Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease2014
- Author(s)
  Akinori Miyashita, Hiroyuki Hatsuta, Masataka Kikuchi, Akihiro Nakaya, Yuko Saito, Tamao Tsukie, Norikazu Hara, Soichi Ogishima, Nobutaka Kitamura, Kohei Akazawa, Akiyoshi Kakita, Hitoshi Takahashi, Shigeo Murayama, Yasuo Ihara, Takeshi Ikeuchi, and Ryozo Kuwano
- Journal Title
  
  Translational Psychiatry
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430181
[Journal Article] Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.2014
- Author(s)
  Tokutake T, Ishikawa A, Yoshimura N, Miyashita A, Kuwano R, Nishizawa M, Ikeuchi T
- Journal Title
  
  Parkinsonism ＆ Related Disorders
  
  Volume: 20 Pages: 262-264
- DOI
  10.1016/j.parkreldis.2013.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25893077
[Journal Article] Relative ratio and level of amyloid-ß 42 surrogate in cerebrospin T, Takeda Mal fluid of familal Alzheimer’s disease patients with presenilin 1 mutations2014
- Author(s)
  Tagami et al.
- Journal Title
  
  Neurodegener Dis. .
  
  Volume: 13 Pages: 166-170
- DOI
  10.1159/000355258
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591234, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-26461746
[Journal Article] SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.2013
- Author(s)
  Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, et al.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 35(2) Pages: 387-387
- DOI
  10.3233/jad-122395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590968, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24510275, KAKENHI-PROJECT-24650149, KAKENHI-PROJECT-24700371, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-22129004
[Journal Article] CSF levels of phosphorylated tau and Aβ(1-38/1-40/1-42) in Alzheimer’s disease with novel PS1 mutations2013
- Author(s)
  Ikeda M, Yonemura K, Kakuda S, Tashiro Y, Fujita Y, Takai E, Hashimoto Y, Makioka K, Furuta N, Ishiguro K, Maruki R, Yoshida J, Miyaguchi O, Tsukie T, Kuwano R, Yamazaki T, Yamaguchi H, Amari M, Takatama M, Harigaya Y, Okamoto K
- Journal Title
  
  Amyloid
  
  Volume: 20 Pages: 107-112
- DOI
  10.3109/13506129.2013.790810
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-23500426, KAKENHI-PROJECT-23591231, KAKENHI-PROJECT-24310144
[Journal Article] Identification of unstable network modules reveals disease modules associated with the progression of Alzheimer’s disease.2013
- Author(s)
  Kikuchi M, Ogishima S, Miyamoto T, Miyashita A, Kuwano R, Nakaya J, Tanaka H
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0076162
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25330333
[Journal Article] Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS2012
- Author(s)
  Shiga A, et al ;
- Journal Title
  
  PLos One
  
  Volume: 7(8)
- DOI
  10.1371/journal.pone.0043120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07914, KAKENHI-PROJECT-22249036, KAKENHI-PROJECT-23240049, KAKENHI-PROJECT-24510275, KAKENHI-PROJECT-24790875, KAKENHI-PLANNED-22129004
[Journal Article] Alterarion of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS2012
- Author(s)
  Shiga A, Ishihara T, Miyashita A, Kuwabara M, Kato T, Watanabe N, Yamahira A, Kondo C, Yokoseki A, Takahashi M, Kuwano R, Kakita A, Nishizawa M, Takahashi H, Onodera O
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240049
[Journal Article] Clinical characteristics and evidence for a common founder in Japanese families with MAPT R406W mutation2011
- Author(s)
  Ikeuchi T, Imamura T, Kawase Y, Kitade Y, Tokutake T, Yajima R, Tsukie T, Miyashita A, Sugishita M, Kuwano R, Nishizawa M
- Journal Title
  
  Dementia Geriatric Cognitive Disorders EXTRA
  
  Volume: 1 Pages: 267-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200041
[Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease : a distinct clinicopathological and biochemical disease entity.2010
- Author(s)
  Fu Y-J, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao Y-S, Tan C-F, Tani T, Koike R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H.
- Journal Title
  
  Acta Neuropathol 120
  
  Pages: 21-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20240037
[Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, parkinsonism and motor neuron disease: a distinct clinicopathological and biochemical disease entity2010
- Author(s)
  Fu Y, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koide R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 120 Pages: 21-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200041
[Journal Article] Hoque MA: Programs for calculating the statistical powers of detecting susceptibility genes in case-control studies based on multistage designs2009
- Author(s)
  Kitamura N, Akazawa K, Miyashita A, Kuwano R, Toyabe SI, Nakamura J, Nakamura N, Sato T
- Journal Title
  
  Bioinformatics 25
  
  Pages: 272-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Programs for calculating the statistical powers of detecting susceptibility genes in case-control studies based on multistage designs2009
- Author(s)
  Kitamura N, Akazawa K, Miyashita A, Kuwano R, Toyabe SI, Nakamura J, Nakamura N, Sato T, Hoque MA
- Journal Title
  
  Bioinformatics 25(2)
  
  Pages: 272-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data2009
- Author(s)
  Fukuda Y, Nakahara Y, Date H, Takahashi Y, Goto J, Miyashita A, Kuwano R, Adachi H, Nakamura E, Tsuji S.
- Journal Title
  
  BMC Bioinformatics 10
  
  Pages: 121-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation2009
- Author(s)
  Kasuga K, Ohno T, Ishihara T, Miyashita A, Kuwano R, Onodera O, Nishizawa M, Ikeuchi T.
- Journal Title
  
  J Neurol 256
  
  Pages: 1351-1353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] GAB2 is not associated with late-onset Alzheimer's disease in Japanese2009
- Author(s)
  Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R.
- Journal Title
  
  Eur J Hum Genet 17
  
  Pages: 682-686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese2009
- Author(s)
  Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, Odani S, Kuwano R, the Japanese Genetic Study Consortium for Alzheimer Disease
- Journal Title
  
  Genomics 93
  
  Pages: 441-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease2009
- Author(s)
  Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, Kawata H, Koyama A, Arima K, Takahashi T, Ikeda M, Shiota H, Tamura M, Shimoe Y, Hirayama M, Arisato T, Yanagawa S, Tanaka A, Nakano I, Ikeda S, Yoshida Y, Yamamoto T, Ikeuchi T, Kuwano R, Nishizawa M, Tsuji S, Onodera O.
- Journal Title
  
  N Engl J Med 360
  
  Pages: 1729-1739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Prediction of Disease-associated Single Nucleotide Polymorphisms Using Virtual Genomes Constructed from a Public Haplotype Database2008
- Author(s)
  Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K
- Journal Title
  
  Methods Inf Med 47(6)
  
  Pages: 522-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations2008
- Author(s)
  Ikeuchi T, Kaneko H, Miyashita A, Nozaki H, Kasuga K, Tsukie T, Tsuchiya M, Imamura T, Ishizu H, Aoki K, Ishikawa A, Onodera O, Kuwano R, Nishizawa M
- Journal Title
  
  ement Geriatr Cogn Disord 26(1)
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Prediction of Disease-associated Single Nucleotide Polymorphisms Using Virtual Genomes Constructed from a Public Haplotype Database2008
- Author(s)
  Toyabe S, Miyashita A, Kitamura N, Kuwano R, Akazawa K
- Journal Title
  
  Methods Inf Med 47(6)
  
  Pages: 522-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes.2008
- Author(s)
  Kitamura N, Akazawa K, Toyabe SI, Miyashita A, Kuwano R, Nakamura J
- Journal Title
  
  Journal of Human Genetics (印刷中)
- NAID
  10021248775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] Epilepsy Genetic Study Group Japan. Genome-wide identification of febrile seizure and releted epilepsy phenotype loci2008
- Author(s)
  Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K,Fujita H, Hirosa S, Kaneko S.
- Journal Title
  
  Epilepsy & Seizure 1(1)
  
  Pages: 30-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes2008
- Author(s)
  Kitamura N, Akazawa K, Toyabe SI, Miyashita A, Kuwano R, Nakamura J
- Journal Title
  
  J Hum Genet 53(5)
  
  Pages: 390-400
- NAID
  10021248775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] A new amyloidβvariant favoring oligomerization in Alzheimer-type dementia2008
- Author(s)
  Tomiyama, T., Nagata, T., Shimada H., Teraoka, R., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Suzuka Ataka, S., et. Al
- Journal Title
  
  Ann Neurol 63(3)
  
  Pages: 377-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Genome-wide identification of febrile seizure and related epilepsy phenotype loci2008
- Author(s)
  Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K, Fujita H, Hirosa S, Kaneko S, & Epilepsy Genetic Study Group Japan.
- Journal Title
  
  Epilepsy & Seizure 1(1)
  
  Pages: 30-9
- NAID
  130000061687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] Novel locus for benign hereditary chorea with adult-onset maps to chromosome 8q21.3-q23.3.2007
- Author(s)
  Shimohata K, Kuwano R, et al.
- Journal Title
  
  Brain (in press)
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] Genetic association of CTNNA3 with late-onset Alzheimer's disease in females2007
- Author(s)
  Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
- Journal Title
  
  Human Molecular Genetics 16(23)
  
  Pages: 2854-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] Genetic association of CTNNA3 with late-onset Alzheimer‘s disease in females2007
- Author(s)
  Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
- Journal Title
  
  Hum Mol Genet 16(23)
  
  Pages: 2854-2869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] 第48回日本神経学会総会シンポジウム西大西洋地域の筋萎縮性側索硬化症/パーキンソン・認知症複合(ALS/PDC)と関連神経変性疾患.紀伊ALS/PDCの分子遺伝学的.2007
- Author(s)
  原賢寿、桑野良三、宮下哲典、小久保康昌、佐々木良元、中原安雄、後藤順、西澤正豊、葛原茂樹、辻省次
- Journal Title
  
  臨床神経 47
  
  Pages: 974-976
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] Genetic association of CTNNA3 with late-onset Alzheimer's disease in females2007
- Author(s)
  Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R.
- Journal Title
  
  Human Molecular Genetics 16(23)
  
  Pages: 2854-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300095
[Journal Article] Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.2006
- Author(s)
  Kuwano R, et al.
- Journal Title
  
  Hum Mol Genet 15
  
  Pages: 2170-2182
- NAID
  40015443849
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease2006
- Author(s)
  Kuwano R.
- Journal Title
  
  Hum Mol Genet 15
  
  Pages: 2170-2182
- NAID
  40015443849
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] Japanese Genetic Study Consortium for Alzeheimer's Disease. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease2006
- Author(s)
  Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y
- Journal Title
  
  Hum Mol Genet. 15
  
  Pages: 2170-2182
- Data Source
  KAKENHI-PROJECT-17020004
[Journal Article] A rare case of hypohidrotic ectodermal dysplasia by compound heterozygous mutations in the EDAR gene.2004
- Author(s)
  Shimomura Y, Kuwano R, et al.
- Journal Title
  
  J Invest Dermatol 123/4
  
  Pages: 649-655
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] Japanese SCA families with an unusual phenotype linked to a locus overlapping with SCA15 locus.2004
- Author(s)
  Hara K, Kuwano R, Tsuji S, et al.
- Journal Title
  
  Neurology 62/4
  
  Pages: 648-651
- Data Source
  KAKENHI-PROJECT-16109006
[Journal Article] TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan.
- Author(s)
  Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S:
- Journal Title
  
  Am J Med Genet Part B (in press)
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan
- Author(s)
  Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S
- Journal Title
  
  Am J Med Genet Part B (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Presentation] 遺伝子レベルから見た高齢期ダウン症者の特徴と治療に向けて2017
- Author(s)
  桑野良三
- Organizer
  第１回成人期ダウン症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K14649
[Presentation] Identification of Serum microRNA As a Potential Biomarker Related to the Progression of Alzheimer’s Disease2017
- Author(s)
  Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikeuchi T, Kuwano R
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  ロンドン（イギリス）
- Year and Date
  2017-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14649
[Presentation] ダウン症とアルツハイマー病に共通する問題2017
- Author(s)
  桑野良三
- Organizer
  日本発達障害学会第52回研究大会
- Data Source
  KAKENHI-PROJECT-16K14649
[Presentation] ダウン症者早期アルツハイマー病の治療法を考える2017
- Author(s)
  桑野良三
- Organizer
  第59回日本小児神経科学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K14649
[Presentation] Identification of serum microRNA as a potential biomarker related the progression of Alzheimer's disease2017
- Author(s)
  Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikeuchi T, Kuwano R.
- Organizer
  AAIC(Alzheimer Association International Conference)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14649
[Presentation] アルツハイマー病感受性領域が近接する染色体領域の同定2015
- Author(s)
  菊地正隆, 原範和, 長谷川舞衣, 宮下哲典, 桑野良三, 池内健, 中谷明弘
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーション青森・ホテル青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] アルツハイマー病感受性領域が近接する染色体領域の同定2015
- Author(s)
  菊地正隆、原範和、長谷川舞衣、宮下哲典、桑野良三、池内健、中谷明弘
- Organizer
  第３４回日本認知症学会
- Place of Presentation
  リンクステーションホール（青森県、青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] バイオマーカーとしてのゲノム解析2015
- Author(s)
  桑野良三
- Organizer
  第３４回日本認知症学会
- Place of Presentation
  リンクステーションホール（青森県、青森市）
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] Molecular genetics of Alzheimer’s disease2015
- Author(s)
  Ryozo Kuwano
- Organizer
  The First International Taiwanese Congress of Neurology
- Place of Presentation
  台湾、台北
- Year and Date
  2015-05-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] Identification of chromosomal regions interacting with susceptibility loci for Alzheimer’s disease2015
- Author(s)
  Kikuchi M, Hara N, Hasegawa M, Miyashita A, Kuwano R, Ikeuchi T, and Nakaya A
- Organizer
  American Society of Human Genetics Annual Meeting 2015
- Place of Presentation
  Baltimore, MD, USA
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] Autopsy confirmed Alzheimer’s disease, especially early onset and apolipoprotein E4 negative male has the variant in the ATP-binding cassette transporter (ABCA7)2015
- Author(s)
  H.Akatsu, M.Tomioka, T.Kanematsu, Y.Toda, H.Yamagata, S.amamoto, H.Ohara, T.Ikeuchi, R.Kuwano, Y.Hashizume, K.Ueda
- Organizer
  International Association of Gerontology and Geriatrics
- Place of Presentation
  タイ、チェンマイ
- Year and Date
  2015-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] アルツハイマー病感受性領域が近接する染色体領域の同定2015
- Author(s)
  菊地正隆, 原範和, 長谷川舞衣, 宮下哲典, 桑野良三, 池内健, 中谷明弘
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] Genetic risk factors and gene expression analysis of dementias2015
- Author(s)
  Ryozo Kuwano, Shigeru Suemitsu
- Organizer
  American Academy of Developmental Medicine and Dentistry
- Place of Presentation
  アメリカ、ロサンジェルス
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] AD/GD CNVdb (Alzheimer's Disease Genomic Databases, Copy Number Variation Database)2015
- Author(s)
  Nakaya A, Kikuchi M, Miyashita A, Hara N, Kasuga K, Nishida N, Tokunaga K, Kuwano R, and Ikeuchi T
- Organizer
  日本バイオインフォマティクス学会2015年年会
- Place of Presentation
  京都大学宇治キャンパスおうばくプラザ
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] Genomic structure and distribution of copy number variations in relation to Japanese Alzheimer's disease2015
- Author(s)
  Nakaya A, Kikuchi M, Miyashita A, Hara N, Kasuga K, Nishida N, Tokunaga K, Kuwano R, and Ikeuchi T
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] アルツハイマー病感受性領域が近接する染色体領域の同定2015
- Author(s)
  菊地正隆, 原範和, 長谷川舞衣, 宮下哲典, 桑野良三, 池内健, 中谷明弘
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] アルツハイマー病の血清バイオマーカーとしてのマイクロRNA解析2015
- Author(s)
  原範和、菊地正隆、宮下哲典、初田裕幸、齊藤祐子、村山繁雄、春日健作、池内健、桑野良三
- Organizer
  第３４回日本認知症学会
- Place of Presentation
  リンクステーションホール（青森県、青森市）
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] 細胞特異的な染色体高次構造は遺伝子発現を調節するのか?2014
- Author(s)
  菊地正隆, 長谷川舞衣, 原範和, 宮下哲典, 中谷明弘, 池内健, 桑野良三
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] ヒラアオノリ配偶子の一過的形質転換系による葉緑体とミトコンドリアの可視化とその動態2014
- Author(s)
  鈴木亮吾，伊藤寛，尾関海，余哲，山崎誠和，豊田敦，桑野和可，河野重行
- Organizer
  日本藻類学会第38回大会
- Place of Presentation
  東邦大学理学部
- Data Source
  KAKENHI-PROJECT-221S0002
[Presentation] AD/GD CNVdb: アルツハイマー病のコピー数変異データベース2013
- Author(s)
  中谷明弘, 宮下哲典, 菊地正隆, 長谷川舞衣, 原範和, 西田奈央, 徳永勝士, 井原康夫, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25430181
[Presentation] 2）細胞特異的なゲノム高次構造解析法の検討2013
- Author(s)
  長谷川舞衣, 原範和, 菊地正隆, 宮下哲典, 中谷明弘, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] AD/GD CNVdb: アルツハイマー病のコピー数変異データベース.2013
- Author(s)
  中谷明弘, 宮下哲典, 菊地正隆, 長谷川舞衣, 原範和, 西田奈央, 徳永勝士, 井原康夫, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] SORL1 is Genetically Associated With Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.2013
- Author(s)
  Miyashita A, Kuwano R, Schellenberg G, Ihara Y, Kanazawa I, Tsuji S, Yamamoto K, Tokunaga K, Nishida N, Yoshida M, Pericak-Vance M, Haines J, Mayeux R, St. George-Hyslop P, Kim JW, Takahashi S, Wang LS, Jun G, Koike A, Farrer L
- Organizer
  AAIC
- Place of Presentation
  アメリカ、ボストン
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] 細胞特異的なゲノム高次構造解析法の検討2013
- Author(s)
  長谷川舞衣,原範和,菊地正隆,宮下哲典,中谷明弘,池内健,桑野良三
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市)
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] AD/GD CNVdb : アルツハイマー病のコピー数変異データベース2013
- Author(s)
  中谷明弘,宮下哲典,菊地正隆,長谷川舞衣,原範和,西田奈央,徳永勝士,井原康夫,池内健,桑野良三
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市)
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] SORL1 is Genetically Associated With Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.2013
- Author(s)
  Miyashita A, Kuwano R, Schellenberg G, Ihara Y, Kanazawa I, Tsuji S, Yamamoto K, Tokunaga K, Nishida N, Yoshida M, Pericak-Vance M, Haines J, Mayeux R, St. George-Hyslop P, Kim JW, Takahashi S, Wang LS, Jun G, Koike A, Farrer L
- Organizer
  AAIC
- Place of Presentation
  アメリカ、ボストン
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] SORL1 is Genetically Associated With Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.2013
- Author(s)
  Miyashita A, Kuwano R, Schellenberg G, Ihara Y, Kanazawa I, Tsuji S, Yamamoto K, Tokunaga K, Nishida N, Yoshida M, Pericak-Vance M, Haines J, Mayeux R, St. George-Hyslop P, Kim JW, Takahashi S, Wang LS, Jun G, Koike A, Farrer L
- Organizer
  AAIC
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-221S0002
[Presentation] 細胞特異的なゲノム高次構造解析法の検討2013
- Author(s)
  長谷川舞衣, 原範和, 菊地正隆, 宮下哲典, 中谷明弘, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] 細胞特異的なゲノム高次構造解析法の検討2013
- Author(s)
  長谷川舞衣, 原範和, 菊地正隆, 宮下哲典, 中谷明弘, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県）
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] 細胞特異的な転写制御にかかわるゲノム高次構造の解析法の検討2013
- Author(s)
  長谷川舞衣,原範和,菊地正隆,中谷明弘,宮下哲典,池内健,桑野良三
- Organizer
  第43回新潟神経学夏期セミナー
- Place of Presentation
  新潟大学脳研究所統合脳機能研究センターセミナーホール(新潟県新潟市)
- Year and Date
  2013-07-26
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] AD/GD CNVdb: アルツハイマー病のコピー数変異データベース2013
- Author(s)
  中谷明弘, 宮下哲典, 菊地正隆, 長谷川舞衣, 原範和, 西田奈央, 徳永勝士, 井原康夫, 池内健, 桑野良三
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県）
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] 細胞特異的な転写制御にかかわるゲノム高次構造の解析法の検討2013
- Author(s)
  長谷川舞衣, 原範和, 菊地正隆, 中谷明弘, 宮下哲典, 池内健, 桑野良三
- Organizer
  第４３回新潟神経学夏期セミナー
- Place of Presentation
  新潟大学（新潟県）
- Data Source
  KAKENHI-PROJECT-24651221
[Presentation] 経験依存的な神経回路の可塑性に関わるクロマチン動態の解析2012
- Author(s)
  酒井晶子、桑野良三、杉山清佳
- Organizer
  第6回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22710183
[Presentation] アルツハイマー型認知症の分子遺伝学2012
- Author(s)
  桑野良三
- Organizer
  日本生物学的精神医学
- Place of Presentation
  神戸
- Year and Date
  2012-09-28
- Invited
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] Genome-wide association study of Alzheimer’s disease: a collaborative genetic study on Alzheimer’s disease with Japan, Korea and the Alzheimer’s Disease Genetics Consortium2012
- Author(s)
  Kuwano R
- Organizer
  the Alzheimer's Association International Conference (AAIC)
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] 臨界期におけるマウス視覚野のクロマチン動態の解析2012
- Author(s)
  酒井晶子、中戸隆一郎、桑野良三、白髭克彦、杉山清佳
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22710183
[Presentation] 日本人における晩期発症型アルツハイマー病のGWAS2011
- Author(s)
  桑野良三
- Organizer
  日本神経科学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] Aberrant splicing ofPOLDIP3 gene in motor neuron with ALS.2011
- Author(s)
  A. SHIGA1, T. ISHIHARA1, A.MIYASHITA1, T. KATO1, M. KUWABARA1, A. YOKOSEKI2, R. KUWANO1, A. KAKITA1,H. TAKAHASHI1, M. NISHIZAWA1, O. ONODERA1
- Organizer
  6th Brain Research Conference RNA-Binding Proteins in NeurologicalDisease
- Place of Presentation
  Washington, D. C.
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] Aberrant splicing of POLDIP3 gene in motor neuron with ALS2011
- Author(s)
  A.SHIGA, T.ISHIHARA, A.MIYASHITA, T.KATO, M.KUWABARA, A.YOKOSEKI, R.KUWANO, A.KAKITA, H.TAKAHASHI, M.NISHIZAWA, O.ONODERA
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington, D.C.
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] Aberrant splicing of POLDIP3 gene in motor neuron with ALS2011
- Author(s)
  A.SHIGA, T.ISHIHARA, A. MIYASHITA, T.KATO, M.KUWABARA, A.YOKOSEKI, R.KUWANO, A.KAKITA, H.TAKAHASHI, M.NISHIZAWA, O.ONODERAI
- Organizer
  6th Brain Research Conference : RNA-Binding Proteins in Neurological Disease
- Place of Presentation
  Washington, D.C.
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] Aberrant splicing ofPOLDIP3 gene in motor neuron with ALS2011
- Author(s)
  A. SHIGA1, T. ISHIHARA1, A.MIYASHITA1, T. KATO1, M. KUWABARA1, A. YOKOSEKI2, R. KUWANO1, A. KAKITA1,H. TAKAHASHI1, M. NISHIZAWA1, O.ONODERA1
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington, D. C.
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] TDP-43 depletion causes splicing defects in the genes associated with endomemb rane system.2010
- Author(s)
  A.SHIGA, T.ISHIHARA, A.MIYASHITA, M.YOKOO, Y..ARIIZUMI, A.YOKOSEKI, R.KUWANO, M.NISHIZAWA, O.ONODERA
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] TDP-43 depletion causes splicingdefects in the genes associated withendomembrane system2010
- Author(s)
  A. SHIGA, T. ISHIHARA, A. MIYASHITA,M. YOKOO, Y. ARIIZUMI, A. YOKOSEKI,R. KUWANO, M. NISHIZAWA, O. ONODERA
- Organizer
  Neuroscience 2010 Saturday
- Place of Presentation
  SanDiego
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22249036
[Presentation] 健忘主体の臨床徴候を呈するタウ遺伝子R406W変異を伴う家族性認知症2010
- Author(s)
  池内健,春日健作,宮下哲典,川瀬康裕,杉下守弘,桑野良三,西澤正豊
- Organizer
  第51回日本神経学会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21200041
[Presentation] Fine SNP mapping in and around the APOE in late-onset Alzheimei disease.2009
- Author(s)
  Kuwano R.
- Organizer
  ICAD
- Place of Presentation
  オイーン(オーストリア)
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] JGSCAD): Fine SNP mapping in and around the APOE in late-onset Alzheimer disease2009
- Author(s)
  Kuwano R, Takei N, Miyashita A, Ihara Y
- Organizer
  The 12th International Conference on Alzheimer's Disease
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] Genomo-waide identification of febrile seizure and related epilepsy phenotype loci2008
- Author(s)
  Yoshida S, Miyashita A, Kuwano R, Kojima T, Zhu G, Kanai K, Fujita K, Hirano S, and Kaneko S.
- Organizer
  7^<th> Asian & Oceanian Epilepsy Congress
- Place of Presentation
  Xiamen. CHINA
- Data Source
  KAKENHI-PROJECT-16109006
[Presentation] Gene Expression Profiling of Postmortem Brain Tissues Affected by Alzheimer's Disease2008
- Author(s)
  Miyashita A, Saitoh Y, Kakita A, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano R
- Organizer
  The 11th International Conference on Alzheimer ' s Disease and Related Disorders
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-29
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] リスクファクターとしての遺伝子2007
- Author(s)
  桑野良三
- Organizer
  第48回日本神経学総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-15
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] Identification of new genetic risk factors2007
- Author(s)
  Kuwano R.
- Organizer
  Alzheimer's Association International Conference on Prevention of Dementia
- Place of Presentation
  Washington D.C
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] てんかん・熱性けいれん遺伝子解析グループ.マイクロサテライトマーカーを用いたFS・GEFS+・SMEIにおける新規責任遺伝子の網羅的検索(第1報).2007
- Author(s)
  吉田秀一, 桑野良三, 宮下哲典, 小島俊男, 佐々木智美, 朱剛, 金井数明, 伊藤正利, 藤田浩史, 廣瀬伸一, 兼子直, ,
- Organizer
  第1回日本てんかん学会東北地方会
- Place of Presentation
  仙台
- Year and Date
  2007-07-14
- Data Source
  KAKENHI-PROJECT-16109006
[Presentation] Genetic Association Study for late-onset Alzheimer's Disease in Japan2007
- Author(s)
  Kuwano R
- Organizer
  The 2nd Alzheimer's Association International Conference on Prevention of Dementia
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-17020004
[Presentation] Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease brains
- Author(s)
  Miyashita A, Kuwano R, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kakita A, Takahashi H, Murayama S, Ihara, Ikeuchi T
- Organizer
  AAIC
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2014-07-11 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] Molecular Genetics of Alzheimer's disease
- Author(s)
  Kuwano R
- Organizer
  1st ITCC
- Place of Presentation
  Taipei International Convention Center
- Year and Date
  2015-05-07 – 2015-05-10
- Invited
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] 認知症の表現型を説明する遺伝子解析の試み
- Author(s)
  桑野良三
- Organizer
  第18回日本認知神経科学会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] アルツハイマー病における生体分子間ネットワーク解析手法の提案
- Author(s)
  菊地正隆, 原範和, 宮下哲典, 初田裕幸, 齊藤祐子, 村山繁雄, 池内健, 桑野良三
- Organizer
  日本認知症学会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-27 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] ヒト剖検脳を用いたアルツハイマー病関連マイクロRNAの解析.
- Author(s)
  原範和、菊地正隆、宮下哲典、初田裕幸、齊藤祐子、村山繁雄、赤津裕康、池内健、桑野良三
- Organizer
  日本認知症学会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-27 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26640122
[Presentation] 認知症の表現型を説明する遺伝子解析の試み
- Author(s)
  桑野良三
- Organizer
  第18回日本認知神経科学会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PLANNED-22129004
[Presentation] 細胞特異的な遺伝子発現は染色体高次構造の影響を受けるのか？
- Author(s)
  菊地正隆, 長谷川舞衣, 原範和, 宮下哲典, 中谷明弘, 池内健, 桑野良三
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] アオサ藻綱ヒラアオノリのゲノム解読と雌雄ゲノムの比較による性決定領域の探索
- Author(s)
  山﨑誠和, 鈴木亮吾, 市原健介, 豊田敦, 桑野和可, 鈴木穣, 河野重行
- Organizer
  日本藻類学会第39回大会
- Place of Presentation
  九州大学
- Year and Date
  2015-03-20 – 2015-03-25
- Data Source
  KAKENHI-PROJECT-221S0002
[Presentation] アルツハイマー病における生体分子間ネットワーク解析手法の提案
- Author(s)
  菊地正隆, 原範和, 宮下哲典, 初田裕幸, 齊藤祐子, 村山繁雄, 池内健, 桑野良三
- Organizer
  日本認知症学会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-27 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-24310144
[Presentation] ヒト剖検脳を用いたアルツハイマー病関連マイクロRNAの解析.
- Author(s)
  原範和、菊地正隆、宮下哲典、初田裕幸、齊藤祐子、村山繁雄、赤津裕康、池内健、桑野良三
- Organizer
  日本認知症学会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-24310144

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KUWANO Ryozo 桑野 良三

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Identification of microRNA editing related to the brains with Alzheimer's diseasePrincipal Investigator

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Molecular analysis of the differentially expressed miRNA related to progression of Alzheimer's diseasePrincipal Investigator

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Identification of target molecules related the progression of Alzheimer's diseasePrincipal Investigator

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Personal genome analysis on Alzheimer's diseasePrincipal Investigator

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KUWANO Ryozo 桑野良三