Hashida Mitsuru 橋田充

… Alternative Names

Researcher Number	20135594
Other IDs
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Affiliation (Current)	2021: 京都大学, 薬学研究科, 名誉教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 京都大学, 薬学研究科, 名誉教授 2016: 京都大学, 薬学研究科, 教授 2011 – 2015: 京都大学, 薬学研究科(研究院), 教授 2012: 京都大学, 大学院・薬学研究科, 教授 1997 – 2011: Kyoto University Graduate Sch.Pharm.Sci.Professor, 薬学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Physical pharmacy / Biological Sciences / Medical pharmacy / 応用薬理学・医療系薬学 / Physical pharmacy / Applied pharmacology / 医薬分子機能学 / Biomedical engineering/Biological material science / Medical engineering assessment Except Principal Investigator Physical pharmacy / Biological Sciences / Physical pharmacy / Biological pharmacy
Keywords	Principal Investigator ターゲティング / ドラッグデリバリーシステム / 遺伝子治療 / 体内動態 / ドラッグデリバリー / カタラーゼ / NFκB / DDS / リポソーム / 癌化学療法 … More Except Principal Investigator ドラッグデリバリーシステム / リンパ節転移 / モノクローナル抗体 / ミサイル療法 / モノクロ-ナル抗体 / 抗体療法 / バイスペシフィック抗体 / がん遺伝子産物 / 画像診断 / イディオタイプ抗体 / 化学療法 / 血管新生 / 遺伝子治療 / 高分子制癌剤 / 油性制癌剤 / スマンクス / デキストラン / drug delivery / transporter / receptor / tissue targeting / pharmacokinetics / blood-brain barrier / cloning / efflux pump / DDS / 転移 / 活性炭 / 腹膜播種性転移 / マイクロスフェア / ガングリオシ-ド抗原 / タ-ゲティング / 臓器潅流実験 / 細胞培養 / 微粒子性運搬体 / 高分子運搬体 / 糖鎖認識機構 / 薬物送達システム / ガングリオシド抗原 / 糖鎖転移酵素遺伝子 / 血管新生阻害剤 / アンチセンス遺伝子 / 高分子化制癌剤 / ターゲッティング / 癌転移 / アンチセンスDNA / マイクロスフェア- / キメラ抗体 / 分子標的 / 分子標的治療 / 新しい物理療法 / トランスレーショナル・リサーチ / 分子創薬 / トランスレーショナルリサーチ / 新しい物療法 / ポストゲノム / 領域間インターフェース / 物理化学 / 薬剤学 / 構造生物学 / 分析化学 / プロテオミックス / セロミックス / EPR効果 / ピラン結合アドリアシン / デキストラン-マイトマイシン / 肝転移の予防 / 癌化学療法 / ターゲティング / 抗癌剤 / 腫瘍移行性 / 腫癌組織灌流 / モーメント解析 / プロドラッグ / マイトマイシンC / ピランコポリマー・アドリアマイシン結合物 / マイトマイシン・デキストラン結合物 / 腫瘍ダーゲティング / 腸癌の肝転移の防止 / 磁性化酵素 / リピオドール制癌剤 / EPRー効果 / 微粒子活性炭 / ペプレオマイシン / モノクローナル抗体NCS / マイトマイシン / アドリアマイシン / 薬物吸収 / 共焦点レーザ顕微鏡 / 走査プローブ顕微鏡 / 創薬研究 / 吸収・透過 / 顕微鏡光学技術 / 顕微光学技術 / 経皮吸収 / 初回通回効果 / 高分子薬物 / Durg absorption / Confocal Microscopy / Scanning Probe Microscopy / Investigation of New Drug / Absorption and Transportion / Optical microscopic technique / effux pump / ドラッグデリバリー / トランスポーター / レセプター / 組織標的化 / 薬物速度論 / ペプチド性医薬品 / 化学修飾 / 電荷 / 高分子化修飾 / ポリエチレングリコ-ル / レセプタ-仲介エンドサイトシス / ス-パ-オキサイドジスムタ-ゼ / 大豆トリプシンインヒビター / ウリカーゼ / 体内挙動 / Peptide Drug / Chemical Modification / Electric Charge / Macromolecular Modification / Polyethyleneglycol / Dextran / Receptor-mediated Transport / Superoxide Dismutase Less

Development of safety evaluation system for DDS carrier based on network toxicologyPrincipal Investigator
- Principal Investigator
  
  Hashida Mitsuru
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Kyoto University
Cell surface modification using non-natural amino acid and its application to drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Hashida Mitsuru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cellPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto University
腫瘍関連マクロファージへの核酸ＤＤＳの開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Therapeutic strategy of drug delivery systems utilizing unique tumor environmentPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyoto University
Long-term gene expression in primary cells by transposon and its application for cell therapyPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto University
トランスポゾンを用いたin vivo遺伝子発現長期化による新規慢性疾患療法の開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
免疫細胞指向性ナノ粒子によるNFkB転写制御と移植拒絶抑制への応用Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Development of gene carriers based on in vivo and intracellular distribution real-time analysisPrincipal Investigator
- Principal Investigator
  
  MITSURU Hashida
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasisPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
NFκB活性化抑制に基づく新しい臓器移植における拒絶抑制法の開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
活性酸素消去酵素の細胞選択的ターゲティング・遺伝子導入によるがん転移抑制Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
New therapeutic strategies for treatment of cancer based on basic research
- Principal Investigator
  
  UEDA Ryuzo
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
ポストゲノムにおける領域間インターフェースの構築と次世代薬学研究者の育成
- Principal Investigator
  
  NAKANISHI Mamoru
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagoya City University
活性酸素消去酵素の細胞選択的ターゲティング・遺伝子導入によるがん転移抑制Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
レポーター遺伝子導入癌細胞を用いた癌転移過程の定量的解析と転移抑制法の開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfectionPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
活性酸素消去酵素の細胞選択的ターゲティング・遺伝子導入によるがん転移抑制Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
物理刺激と生物学的分子認識の統合による高効率・細胞選択的遺伝子デリバリーPrincipal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto University
Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface propertyPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
受容体介在性エンドサイトーシスを利用した活性酸素分解酵素のダブルターゲティングPrincipal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto University
分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発Principal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
動態-発現相関の解析に基づくin vivo遺伝子導入キャリアーシステムの分子設計Principal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
ドラッグデリバリーの空間的・時間的制御Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Systematic development of targeting systams for prevention of tissue damages in organ transplantationPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYOTO UNIVERSITY
ドラッグデリバリーシステムを利用した癌のターゲティング療法
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics
- Principal Investigator
  
  TSUJI Akira
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Establishment of the theory based on a skin diffusion model for the optimal design of a new approach to enhanced trandermal drug deliveryPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
ドラッグデリバリーシステムを利用した癌のターゲティング療法
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Prefectural University of Medicine
ドラッグデリバリーの空間的・時間的制御Principal Investigator
- Principal Investigator
  
  橋田満
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Bioimaging and theory for drug absorption in living cells
- Principal Investigator
  
  NAKANISHI Mamoru
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagoya City University
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
ドラッグテリバリーシステムを利用した癌のターゲティング療法
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto Prefectural University of Medicine
Establishment of Evaluation Method for Function of Drug Targeting Systems and Systematization of their Physicochemical Character-Function RelationshipPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
モノクローナル抗体による腫瘍関連抗原の検出と治療への応用
- Principal Investigator
  
  高橋利忠
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
モノクロ-ナル抗体による腫瘍関連抗原の検出と治療への応用
- Principal Investigator
  
  高橋利忠
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
タ-ゲティング型製剤の製剤特性ー機能相関の体系化
- Principal Investigator
  
  瀬崎仁
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
抗がん剤のがん病巣集積性評価法の確立とタ-ゲティング型抗がん剤開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Pharmacokinetic modeling and penetration enhancement of the percutaneous drug absorption based on diffusion theoryPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
抗がん剤のがん病巣集積性評価法の確立とターゲティング型抗癌剤開発Principal Investigator
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
薬物送達システム(DDS)を利用した癌転移の化学療法に関する研究
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto Prefectural University of Medicine
Drug Delivery Systemを利用した癌転移の化学療法に関する研究
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto Prefectural University of Medicine
Control of biopharmaceutical properties of peptide drugs by chemical modification employing carbohydrates
- Principal Investigator
  
  SEZAKI Hitoshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYOTO UNIVERSITY
Establishment of a new theory for assessment of drug dispositionPrincipal Investigator
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYOTO UNIVERSITY
制癌霊の高分子化と油性化による腫瘍親和性の増強に関する基礎的研究
- Principal Investigator
  
  前田浩
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
制癌剤の高分子化と油性化による腫瘍親和性の増強に関する基礎的研究
- Principal Investigator
  
  前田浩
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
薬物の腫瘍移行性評価システムの開発とそれを利用したターゲティング型抗癌剤設計
- Principal Investigator
  
  瀬崎仁
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University

[Book] ナノバイオ技術と最新創薬応用研究第5 章ナノバイオ技術を応用した薬物・細胞動態の制御と評価2012
- Author(s)
  樋口ゆり子、橋田充、メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23659284
[Book] ナノバイオ技術と最新創薬応用研究、第5章　ナノバイオ技術を応用した薬物・細胞動態の制御と評価2012
- Author(s)
  樋口ゆり子、橋田充
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23659284
[Journal Article] Evaluation of the Theranostic Potential of Perfluorohexane-Based Acoustic Nanodroplets2019
- Author(s)
  Abdalkader R, Unga J, Yamashita F, Maruyama K, Hashida M
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 12 Pages: 2038-2044
- DOI
  10.1248/bpb.b19-00525
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01861, KAKENHI-PROJECT-18K19939
[Journal Article] The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection2017
- Author(s)
  Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M
- Journal Title
  
  Drug Delivery
  
  Volume: 24 Pages: 320-327
- DOI
  10.1080/10717544.2016.1250139
- NAID
  120006329084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01861, KAKENHI-PROJECT-17H00864
[Journal Article] Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex <i>via</i> Activation of Unfolded Protein Response2014
- Author(s)
  K. Matsumura, C. Sakai, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37(4) Issue: 4 Pages: 648-653
- DOI
  10.1248/bpb.b13-00930
- NAID
  130003390969
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] <i>In Vitro</i> Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages2014
- Author(s)
  Y. Kono, S. Kawakami, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37(1) Issue: 1 Pages: 137-144
- DOI
  10.1248/bpb.b13-00659
- NAID
  130003382116
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072, KAKENHI-PROJECT-23689003
[Journal Article] Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase.2014
- Author(s)
  Hideyuki Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita and Mitsuru Hashida
- Journal Title
  
  Journal of Biotechnology
  
  Volume: 186 Pages: 139-147
- DOI
  10.1016/j.jbiotec.2014.07.012
- NAID
  120005466731
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670259, KAKENHI-PROJECT-25702028
[Journal Article] Tumour-associated macrophage targeted NF-kappaB decoy transfection with mannose-modified bubble lipoplexes inhibits tumour growth in tumour bearing mice2014
- Author(s)
  Y. Kono, S. Kawakami, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: (in press)
- DOI
  10.3109/1061186x.2014.880443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072, KAKENHI-PUBLICLY-25114705
[Journal Article] Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice2013
- Author(s)
  M. Ikemura, M. Nishikawa, K. Kusamori, M. Fukuoka, F. Yamashita, M. Hashida
- Journal Title
  
  J. Controlled Release
  
  Volume: 170(2) Pages: 191-197
- DOI
  10.1016/j.jconrel.2013.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] Enhancement of gene expression by transcriptional activation using doxorubicin-loaded liposome/pDNA complexes2012
- Author(s)
  K. Un, Y. Kono, F. Yamashita, S. Kawakami, M.Hashida
- Journal Title
  
  Pharmazie
  
  Volume: 67(5) Pages: 400-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound -responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation2012
- Author(s)
  Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Hepatology
  
  Volume: (in press) Pages: 259-269
- DOI
  10.1002/hep.25607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01875, KAKENHI-PUBLICLY-23114506, KAKENHI-PROJECT-23240072, KAKENHI-PROJECT-23500567, KAKENHI-PROJECT-23689003
[Journal Article] Enhancement of gene expression by transcriptional activation using doxorubicin-loaded liposome/pDNA complexes2012
- Author(s)
  Keita Un, Yusuke Kono, Mitsuru Yoshida, Fumiyoshi Yamashita, Shigeru Kawakami and Mitsuru Hashida
- Journal Title
  
  Pharmazie
  
  Volume: 67 Pages: 400-405
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23114506
[Journal Article] The involvement of NK cells activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice2012
- Author(s)
  Shuwen Zhou・Shigeru Kawakami・Yuriko Higuchi・Fumiyoshi Yamashita・Mitsuru Hashida
- Journal Title
  
  Clin. Exp. Metastasis
  
  Volume: 29 Pages: 63-70
- DOI
  10.1007/s10585-011-9429-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02743, KAKENHI-PROJECT-23240072
[Journal Article] Cration of pure nanodrugs and their anticancer properties2012
- Author(s)
  H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 51 Pages: 10315-10318
- DOI
  10.1002/anie.201204596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072, KAKENHI-PROJECT-23658098, KAKENHI-PROJECT-24300162, KAKENHI-PROJECT-24650263, KAKENHI-PROJECT-24688011
[Journal Article] Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells2011
- Author(s)
  Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M
- Journal Title
  
  J Biotechnol
  
  Volume: 154 Pages: 205-208
- DOI
  10.1016/j.jbiotec.2011.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J01309, KAKENHI-PROJECT-23659284
[Journal Article] Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells.2011
- Author(s)
  Hideyuki Nakanishi, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita and Mitsuru Hashida
- Journal Title
  
  Journal of Biotechnology
  
  Volume: Vol.154 、No.4 Pages: 205-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659284
[Journal Article] PiggyBac Transposon Mediated Long-term Gene Expression in Mice2010
- Author(s)
  Nakanishi H, Higuchi Y, Hashida M., et al.
- Journal Title
  
  Molecular Therapy
  
  Volume: 18(4) Pages: 707-714
- NAID
  120002515182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659008
[Journal Article] Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice.2010
- Author(s)
  S. Zhou, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Cancer Letters 287(1)
  
  Pages: 75-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Strategies for In Vivo Delivery of siRNAs : Recent Progress2010
- Author(s)
  Higuchi Y, Kawakami S, Hashida M.
- Journal Title
  
  BioDrugs
  
  Volume: 24(3) Pages: 195-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659008
[Journal Article] Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase.2009
- Author(s)
  K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 137(2)
  
  Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Immunostimulatory Characteristics Induced by LinearPolyethyleneimine/plasmid DNA Complexes in Cultured Macrophages2009
- Author(s)
  Yasunori Saito, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Human Gene Therapy 20(2)
  
  Pages: 137-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.2009
- Author(s)
  T. Okuda, S. Kawakami, Y. Higuchi, Y. Oka, T. Satoh, M. Yokoyama, F. Yamashita, M. Hashida
- Journal Title
  
  International Journal of Pharmaceutics 373(1-2)
  
  Pages: 100-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Anti-tumor effect of all-trans retinoic acid loaded polymeric micelles in solid tumor bearing mice.2008
- Author(s)
  N. Chansri, S. Kawakami, M. Yokoyama, T. Yamamoto, P. Charoensit, M. Hashida
- Journal Title
  
  Pharmaceutical Research 25(2)
  
  Pages: 428-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Insertion of nuclear factor-κB binding sequence into plasmid DNA for increased transgene expression in colon carcinomacells2008
- Author(s)
  Oranuch Thanaketpaisarn, Makiya Nishikawa, Takayuki Okabe, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Biotechnology 133(1)
  
  Pages: 36-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Renal press-mediatedtransfection method for plasmid DNAand siRNA to the kidney2008
- Author(s)
  Hidefumi Mukai, Shigeru Kawakami, Mitsuru Hashida
- Journal Title
  
  Biochemical and Biophysical Research Communications 372(3)
  
  Pages: 383-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Mannosylated semiconductor quantum dots for the labeling of macrophage.2008
- Author(s)
  Y. Higuchi, M. Oka, S. Kawakami, M. Hashida
- Journal Title
  
  Journal of Controlled Release 125(2)
  
  Pages: 131-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Pharmacokinetic considerations reganding non-viral cancer gene theraphy2008
- Author(s)
  Makiya Nishikawa, Yoshinobu Takakura,Mitsuru Hashida
- Journal Title
  
  Cancer Science 95(5)
  
  Pages: 856-862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] SOD derivatives prevent metastatic tumor gtowth aggravated by tumor removal.2008
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, M. Ikemura, F. Yamashita, M. Hashida
- Journal Title
  
  Clinical & Experimental Metastasis 25(5)
  
  Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.2008
- Author(s)
  T. Okuda, S. Kawakami, M. Yokoyama, T. Yamamoto, F. Yamashita, M. Hashida
- Journal Title
  
  International Journal of Pharmaceutics 357
  
  Pages: 318-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Hydrogen perpxide-mediated nuclear KappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.2008
- Author(s)
  Y. Kobayashi, M. Nishikawa, K. Hyoudou, F. Yamashita, M. Hashida
- Journal Title
  
  Cancer Science 99(8)
  
  Pages: 1546-1552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Hepatocyte-selective gene transfer by galactosylated protein/linear polyethylenimine/plasmid DNA complexes in mice2007
- Author(s)
  Miyuki Hohokabe, Yuriko Higuchi, Hidefumi Mukai, Shigeru Kawakami, Mitsuru Hashida
- Journal Title
  
  Journal of Biome dical Nanotechnology 3(3)
  
  Pages: 277-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationicliposomes in mice2007
- Author(s)
  Ayumi Sato, Motoki Takagi, Akira Shimamoto, Shigeru Kawakami, Mitsuru Hashida
- Journal Title
  
  Biomaterials 28(7)
  
  Pages: 1434-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 122(2)
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, S. Mukai, M. Ikemura, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 119
  
  Pages: 121-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] The potential role of fucosylated cationic liposome/NFkB decoy complexesin the treatment of cytokine-related liver disease2007
- Author(s)
  Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Biomaterials 28(3)
  
  Pages: 532-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Analysis of in vivo NF-kappaB activation during liver inflammation in mice: prevention by catalase delivery.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Molecular Pharmacology 71(2)
  
  Pages: 446-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Efficient protection by cationizedcatalase against H2O2 injury in primary cultured alveolar epithelial cells2007
- Author(s)
  Takayuki Nemoto, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 121(1-2)
  
  Pages: 74-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity.2007
- Author(s)
  S. Ma, M. Nishikawa, K. Hyoudou, R. Takahashi, M. Ikemura, Y. Kobayashi, F. Yamashita, M. Hashida
- Journal Title
  
  Kidney International 72(12)
  
  Pages: 1474-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.2006
- Author(s)
  T. Okuda, S. Kawakami, T. Maeie, T. Niidome, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 114(1)
  
  Pages: 69-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipidconntaining galactosylated liposomes for hepatocellular carcinoma-selec tive targeting2006
- Author(s)
  Takeshi Terada, Mieko Iwai, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 111(3)
  
  Pages: 333-342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice.2006
- Author(s)
  T. Okuda, S. Kawakami, N. Akimoto, T. Niidome, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 116(3)
  
  Pages: 330-336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase.2006
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Clinical & Experimental Metastasis 23(5-6)
  
  Pages: 269-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Pegylated catalase prevents metastatic tumor growth aggravated by tumor removal.2006
- Author(s)
  Hyoudou, K., Hashida M., et al.
- Journal Title
  
  Free Radical Biol. Med. 41(9)
  
  Pages: 1449-1458
- Data Source
  KAKENHI-PROJECT-16062101
[Journal Article] Analysis of the molecular interaction of glycosylated prpteins with rabbit liver asialoglycoprotein receptors using surface plasmon resonance spectroscopy2006
- Author(s)
  Takeshi Terada, Makiya Nishikawa, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 41
  
  Pages: 966-972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Inhibition of pulmonary metastasis by all-trans retinoic acid incorporated in cationic liposomes in mice.2006
- Author(s)
  S. Suzuki, S. Kawakami, N. Chansri, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 116(1)
  
  Pages: 58-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Improved anti-oxidant activity of superoxide dismutase by direct chemical modification2006
- Author(s)
  Ishimoto N, Nemoto T, Nagayoshi K, Yamashita F, Hashida M
- Journal Title
  
  J.Control.Release 111(1-2)
  
  Pages: 204-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.2006
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Umeyama, F. Yamashita, M. Hashida
- Journal Title
  
  Free Radical Biology & Medicine 41(9)
  
  Pages: 1449-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Inhibition of peritoneal dissemination of tumor cells bysingle dosing of phosphodiester CpGoligonucleotide/cationic liposome complex2006
- Author(s)
  Yukari Kuramoto, Makiya Nishikawa, Kenji Hyoudou, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 115(2)
  
  Pages: 226-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid conntaining galactosylated liposomes for hepatocellular carcinoma-selective targeting.2006
- Author(s)
  T. Terada, M. Iwai, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 111(3)
  
  Pages: 333-342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Liver targeting of catalase by cationization for prevention of acute liver failure in mice2006
- Author(s)
  Ma SF, Nishikawa M, Katsumi H, Yamashita F, Hashida M.
- Journal Title
  
  J.Control.Release 110(2)
  
  Pages: 273-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice2006
- Author(s)
  Shigeru Kawakami, Yoshitaka Ito, Pensri Charoensit, Fumiyoshi Yamashita,Mitsuru Hashida
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 317(3)
  
  Pages: 1382-1390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Tissue-specific characteristics of in vivo electric gene transfer by tissue and intravenous injection of plasmid DNA.2005
- Author(s)
  O. Thanaketpaisarn, M. Nishikawa, F. Yamashita, M. Hashida
- Journal Title
  
  Pharmaceutical Research 22(6)
  
  Pages: 883-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex.2005
- Author(s)
  S. Fumoto, S. Kawakami, K. Shigeta, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 315(2)
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex2005
- Author(s)
  Fumoto, S., Hashida, M., et al.
- Journal Title
  
  J Pharmacology and Experimental Therapeutics 315(2)
  
  Pages: 484-493
- Data Source
  KAKENHI-PROJECT-16062101
[Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation2005
- Author(s)
  Sakai M, Nishikawa M, Thanaketpaisarn O, Yamashita F, Hashida M.
- Journal Title
  
  Gene Ther. 12(7)
  
  Pages: 607-616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo2005
- Author(s)
  Katsumi H, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 314(3)
  
  Pages: 1117-1124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes.2005
- Author(s)
  M. Nishikawa, K. Hyoudou, Y. Kobayashi, Y. Umeyama, Y. Takamura, M. Hashida
- Journal Title
  
  Journal of Controlled Release 109
  
  Pages: 101-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration.2005
- Author(s)
  S. Kawakami, P. Opanasopit, M. Yokoyama, N. Chansri, T. Yamamoto, T. Okano, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Pharmaceutical Sciences 94(2)
  
  Pages: 2606-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Cationic charge-dependent hepatic delivery of amidated serum albumin2005
- Author(s)
  Ma SF, Nishikawa M, Katsumi H, Yamashita F, Hashida M.
- Journal Title
  
  J.Control.Release 102(3)
  
  Pages: 583-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Uptake characteristics of galactosylated emulsion by HepG2 hepatoma cells2005
- Author(s)
  Managit C, Kawakami S, Yamashita F, Hashida M.
- Journal Title
  
  Int.J.Pharm. 301(1-2)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation.2005
- Author(s)
  M. Sakai, M. Nishikawa, O. Thanaketpaisarn, F. Yamashita, M. Hashida
- Journal Title
  
  Gene Therapy 12(7)
  
  Pages: 607-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation2004
- Author(s)
  Fumoto S, Kawakami S, Ito Y, Shigeta K, Yamashita F, Hashida M.
- Journal Title
  
  Mol.Ther. 10(4)
  
  Pages: 719-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin : delivery of nitric oxide in vivo2004
- Author(s)
  Katsumi H, Nishikawa M, Ma SF, Yamashita F, Hashida M.
- Journal Title
  
  J.Pharm.Sci. 93(9)
  
  Pages: 2343-2352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice2004
- Author(s)
  Hattori Y, Kawakami S, Suzuki S, Yamashita F, Hashida M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 317(4)
  
  Pages: 992-999
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation.2004
- Author(s)
  Fumto, S., Hashida M.et al.
- Journal Title
  
  Mol.Ther. 10
  
  Pages: 719-729
- Data Source
  KAKENHI-PROJECT-16062101
[Journal Article] Glycosylated cationic liposomes for carbohydrate receptor-mediated gene transfer2003
- Author(s)
  Nishikawa M, Kawakami S, Yamashita F, Hashida M.
- Journal Title
  
  Methods Enzymol. 373
  
  Pages: 384-399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver2003
- Author(s)
  Morimoto K, Nishikawa M, Kawakami S, Nakano T, Hattori Y, Fumoto S, Yamashita F, Hashida M.
- Journal Title
  
  Mol.Ther. 7(2)
  
  Pages: 254-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Analysis of hepatic disposition of native and galactosylated polyethylenimine complexed with plasmid DNA in perfused rat liver2003
- Author(s)
  Fumoto S, Kawakami S, Ishizuka M, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  Drug Metab.Pharmacokinet. 18(4)
  
  Pages: 230-237
- NAID
  10012458871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I : poly C in a murine lung metastasis model2003
- Author(s)
  Sakurai F, Terada T, Maruyama M, Watanabe Y, Yamashita F, Takakura Y, Hashida M.
- Journal Title
  
  Cancer Gene Ther. 10(9)
  
  Pages: 661-668
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver2003
- Author(s)
  Fumoto S, Nakadori F, Kawakami S, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  Pharm.Res. 20(9)
  
  Pages: 1452-1459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study2003
- Author(s)
  Nishikawa M, Nakano T, Okabe T, Hamaguchi N, Yamasaki Y, Takakura Y, Yamashita F, Hashida M.
- Journal Title
  
  Bioconjug.Chem. 14(5)
  
  Pages: 955-961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Presentation] DDSの進歩と将来像：医薬品・医療機器・再生医療統制品の展開に向けて2018
- Author(s)
  橋田　充
- Organizer
  第34回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] 薬物投与技術の進歩と未来の医療2018
- Author(s)
  橋田　充
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] Bio-distribution characteristics of liposomes bearing structurally simplified sialyl Lewis X2018
- Author(s)
  Yuuki Yamane,Chanikarn Chantarasrivong, Ryosaku Ohta, Yuriko Higuchi, Mitsuru Hashida, Fumiyoshi Yamashita
- Organizer
  日本薬物動態学会第33回年会/MDO国際合同学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] ユビキチン－プロテアソーム系によるリプレッサー分解を利用した新規遺伝子発現制御システムの構築2017
- Author(s)
  〇高見理沙、樋口ゆり子、佐々木明彦、山下富義、橋田　充
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] Progress in drug administration technology and the future of medicine2017
- Author(s)
  橋田　充
- Organizer
  The Cutting Edge in Pharmaceutical Sciences -50 Years of Progress Celebrating Les Benet’s 80th Birthday Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] Functional Characterization of novel Sialyl Lewix X mimic coated-liposomes targeting to E-selectin2016
- Author(s)
  Chanikarn Chantarasrivong, Akiharu Ueki, Hiromune Ando, Shinya Nakamura, Isao Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita, Makoto Kiso, Mitsuru Hashida
- Organizer
  3ｒｄ International Conference on Biomaterials Science in Tokyo
- Place of Presentation
  東京大学本郷キャンパス（東京）
- Year and Date
  2016-11-28
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] 医療イノベーションを支えるサイエンス2016
- Author(s)
  橋田　充
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] Development and evaluation of sialyl lewis X mimic-coated liposomes2016
- Author(s)
  Chanikarn Chantarasrivong, Akiharu Ueki, Hiromune Ando, Shinya Nakamura, Isao Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita, Makoto Kiso, Mitsuru Hashida
- Organizer
  The 1st Workshop Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  京都教育文化センター（京都）
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] mKO2の特定の位置で結合したmKO2-PEG-DSPE結合体の合成と細胞膜表面修飾への応用2016
- Author(s)
  ○樋口ゆり子、杉田かおり、山下富義、橋田　充
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K14940
[Presentation] ペプチドPEG脂質を用いて表面修飾された間葉系幹細胞と血管内皮細胞との接着における鎖長の影響2015
- Author(s)
  ○樋口ゆり子、小田敬昌、山下富義、橋田　充
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K14940
[Presentation] 非天然アミノ酸を介して結合させたタンパク質-PEG脂質誘導体による細胞膜表面修飾2015
- Author(s)
  ○杉田かおり、樋口ゆり子、山下富義、橋田　充
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学薬学研究院　亥鼻キャンパス（千葉県）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K14940
[Presentation] Pharmaceutical Sciences 2020: Cutting Edge Technologies in Drug Delivery2014
- Author(s)
  Mitsuru Hashida
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne Convention and Exhibition Center
- Year and Date
  2014-04-06
- Invited
- Data Source
  KAKENHI-PROJECT-25670259
[Presentation] ターゲティング型ＤＤＳの設計と評価2014
- Author(s)
  橋田充
- Organizer
  第３０回日本ＤＤＳ学会学術集会
- Place of Presentation
  慶應義塾大学薬学部
- Year and Date
  2014-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-25670259
[Presentation] マンノース修飾バブルリポソームを用いたNF-kappaB 活性制御による腫瘍関連マクロファージのphenotype 変化2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、鈴木亮、丸山一雄、山下富義、橋田充
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち(愛知県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] マンノース修飾バブルリポソームを用いたNF-kappaB活性制御による腫瘍関連マクロファージのphenotype変化2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、鈴木亮、丸山一雄、山下富義、橋田充
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Evaluation of the inhibition of NF-kB activation by NF-kB decoy transfection in M2 like macrophages using mannose-modified bubble lipoplexes with ultrasound exposure2013
- Author(s)
  Yusuke Kono, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  3rd International Symposium on Carcinogenic Spiral and International Symposium on Tumor Biology in Kanazawa
- Place of Presentation
  金沢エクセルホテル東急（石川県）
- Year and Date
  2013-01-24
- Data Source
  KAKENHI-PUBLICLY-23114506
[Presentation] Ultrasound triggered doxorubicin loaded microbubbles for effective therapeutic outcomes in melanoma2013
- Author(s)
  Rodi Abdalｋader, Mitsuru Hashida, Shigeru Kawakami, Ryo Suzuki, Kazuo Maruyama
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Visualization of IkappaBalpha dagradation in hela cells with IkappaBalpha fragments fused to mK022013
- Author(s)
  Nilufar Rahimova, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第28回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25670259
[Presentation] マンノース６リン酸受容体を標的としたがん細胞指向性新規糖修飾リポソームの開発2013
- Author(s)
  松田顕也、川上茂、安藤弘宗、樋口ゆり子、山下富義、木曽真、橋田充
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都府）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] NF-kB decoyの腫瘍関連マクロファージ選択的DDSの開発：TAM phenotypeの再分化の誘導評価2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Inhibition of tumor growth by NF-kappaB decoy transfection into TAM using mannose-modified bubble lipoplexes in mice2013
- Author(s)
  河野裕允、川上茂、鈴木亮、丸山一雄、橋田充
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Inhibition of tumor growth by NF-κ B decoy transfection into TAM using mannose-modified bubble lipoplexes in mice2013
- Author(s)
  河野裕允、川上茂、鈴木亮、丸山一雄、橋田充
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Ultrasound triggered doxorubicin loaded microbubbles for effective therapeutic outcomes in melanoma2013
- Author(s)
  R. Abdalkader, M. Hashida, S. Kawakami, R. Suzuki, K. Maruyama
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] 哺乳類細胞におけるpiggyBacトランスポゾンを用いた遺伝子組込みに対してベクターの設計並びに投与量が与える影響2012
- Author(s)
  中西秀之、樋口ゆり子、川上　茂、山下富義、橋田　充
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] 配列選択的DNA結合蛋白質を用いた位置選択的遺伝子組込み型ベクターの開発2012
- Author(s)
  中西秀之、樋口ゆり子、川上　茂、山下富義、橋田　充
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] NF-kB を標的とする抑制性オリゴ核酸による癌微小環境中のマクロファージの免疫再賦活化2012
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Place of Presentation
  仙台市民会館(宮城県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] GRP78 siRNAリポプレックスによるがん細胞アポトーシスの誘導と抗がん剤耐性の克服2012
- Author(s)
  松村一史、川上茂、山下富義、橋田充
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] 薬物治療とドラッグデリバリーシステム2012
- Author(s)
  橋田充
- Organizer
  薬工連携セミナー
- Place of Presentation
  立命館大学びわこくさつキャンパス(滋賀県)
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] 配列選択的 DNA 結合蛋白質を用いた位置選択的遺伝子組込み型ベクターの開発2012
- Author(s)
  中西秀之、樋口ゆり子、川上茂、山下富義、橋田充
- Organizer
  第28回日本 DDS学会学術集会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] 哺乳類細胞におけるpiggyBac トランスポゾンを用いた遺伝子組込みに対してベクターの設計並びに投与量が与える影響2012
- Author(s)
  中西秀之、樋口ゆり子、川上茂、山下富義、橋田充
- Organizer
  第35回日本分子生物学会年会、
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡(福岡県)
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] NF-kBを標的とする抑制性オリゴ核酸による癌微小環境中のマクロファージの免疫再賦活化2012
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム２０１２
- Place of Presentation
  仙台市民会館（宮城県）
- Year and Date
  2012-09-24
- Data Source
  KAKENHI-PUBLICLY-23114506
[Presentation] New Drug Delivery Systems2012
- Author(s)
  Mitsuru Hashida
- Organizer
  3rd International Regulatory Workshop on A to Z on Bioequivalence
- Place of Presentation
  The Hungarian Academy of Sciences (Budapest, Hungary)
- Invited
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] NF-ｋBを標的とする抑制性オリゴ核酸による癌微小環境中のマクロファージの免疫再賦活化2012
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム２０１２
- Place of Presentation
  仙台市民会館（宮城県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] ドキソルビシン封入リポプレックスによるAP-1, NF-kB活性化に基づく遺伝子導入効率の改善2012
- Author(s)
  河野裕允、運敬太、吉田允、山下富義、川上茂、橋田充
- Organizer
  医療薬学フォーラム2012
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PUBLICLY-23114506
[Presentation] New Drug Delivery Systems2012
- Author(s)
  M. Hashida
- Organizer
  3rd International Regulatory Workshop on A to Z on Bioequivalence
- Place of Presentation
  The Hungarian Academy of Sciences, Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Evalution of the inhibition of NF-κB activity by using decoy oligonucleotides on the immune response of macrophages cultured in various cancer cells conditioned medium2012
- Author(s)
  Yusuke Kono, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都大学薬学部（京都府）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Evalustion of endosomal escape of lysine-histidine dendrons by live cell imaging2011
- Author(s)
  Yuriko Higuchi, Kai-ling Chang, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場(広島県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Development of piggyBac transposon-based vector system for long-term gene expression.2011
- Author(s)
  Hideyuki Nakanishi, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  The 6th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Seoul (Korea)
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] New technologies impacting drug discovery2011
- Author(s)
  橋田充
- Organizer
  World Congress of Pharmacy and Pharmaceutical Sciences 2011
- Place of Presentation
  ハイデラバード(インド)
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Mechanisms of Enhanced Gene Expression by Gene Transfer Using Ultrasound-Responsive and Mannose-Modified Gene Carriers2011
- Author(s)
  K.Un, S.Kawakami, M.Yoshida, R.Suzuki, K.Maruyama, F.Yamashita, M.Hashida
- Organizer
  AMERICAN SOCIETY of GENE & CELL THERAPY (ASGCT) 14th Annual Meeting
- Place of Presentation
  シアトル(アメリカ合衆国)(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PUBLICLY-23114506
[Presentation] Development of piggyBac transposon-based vector system for long-term gene expression2011
- Author(s)
  Hideyuki Nakanishi, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  The 6th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Seoul (Korea)
- Data Source
  KAKENHI-PROJECT-23659284
[Presentation] piggyBacトランスポゾンを用いた遺伝子発現持続化における線状・環状DNA間の比較2010
- Author(s)
  中西秀之, 樋口ゆり子, 橋田充, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター (岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21659008
[Presentation] 長期発現に向けたpiggyBacトランスポゾン導入ベクター設計の最適化2010
- Author(s)
  中西秀之、樋口ゆり子、川上茂、山下富義、橋田充
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  北海道大学学術交流会館(北海道)
- Year and Date
  2010-06-02
- Data Source
  KAKENHI-PROJECT-21659008
[Presentation] CpG DNA lipoplex経鼻投与による肺転移・腹膜播種抑制の機構解明2010
- Author(s)
  周舒文, 川上茂, 山下富義, 橋田充
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] CpGDNA lipoplexp経鼻投与による肺転移・腹膜播種抑制の機構解明2010
- Author(s)
  周舒文, 川上茂, 山下富義, 橋田充
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] piggyBacトランスポゾンを用いたEmGFP長期発発現骨髄由来間葉系幹細胞の構築2009
- Author(s)
  奥村聡子, 樋口ゆり子, 橋田充, 他
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル (東京都)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21659008
[Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009
- Author(s)
  増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル(東京)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] 医療薬学のカッティングエッジ:時空世界に思いを込めて2009
- Author(s)
  橋田充
- Organizer
  第19回日本医療薬学会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009
- Author(s)
  増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル(東京都)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Enhanced growth inhibition of metastatic lung tumor by intravenous injection of IL12-ATRA-lipoplexes in mice2009
- Author(s)
  Pensri Charoensit, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Glycosylated liposomes for drug nucleic acids delivery2008
- Author(s)
  Shigeru Kawakami, Yuriko Higuchi, Mitsuru Hashids
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  黄浜シンポジア
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] 抗体-アミノ酸デンドリマーコンジュゲートによるHER2選択的細胞内デリバリー2008
- Author(s)
  宮野拓也、川上茂、新留琢郎、橋田充
- Organizer
  第24回日本dds学会
- Place of Presentation
  六本木アカデミーヒルズ(東京)
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Inhalation of Dexamethasone Palmitate Encapsulated Mannosylated Liposomes Efficiently Ameliorates LPS-Induced Lung Inflammation in Rats2008
- Author(s)
  Wassana Wijagkanalan, Shigeru Kawakami, Mariko Kuroda, Hitoshi Sasaki, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Inhalation of Dexamethasone Palmitate Encapsulated Mannosylated Liposomes Efficiently Ameliorates LPS-Induced Lung Inflammation in Rats2008
- Author(s)
  Wassana wijagkanalan, Shigeru Kawakami, Mariko Kuroda, Hitoshi Sasaki, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リボソーム研究会議
- Place of Presentation
  横浜シンポジア
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Glycosylated liposomes for drug nucleic acids delivery2008
- Author(s)
  Shigeru Kawakami, Yuriko Higuchi, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜シンポジア(神奈川)
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Evaluation of proinflammatory cytokine production induced by siRNA/polyethylenimine complexes2008
- Author(s)
  Pensri Charoensit, 川上茂, 山下富義, 橋田充
- Organizer
  第24回日本DDS学会
- Place of Presentation
  六本木アカデミーヒルズ
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] カタラーゼデリバリーによる癌の接着抑制2008
- Author(s)
  古林裕貴、西川元也、橋田充
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Evaluation of proinflammatory cytokine production inducedby siRNA/polyethylenimine complexes2008
- Author(s)
  Pensri Charoensit、川上茂、山下富義、橋田充
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] 抗体-アミノ酸デンドリマーコンジュゲートによるHER2選択的細胞内デリバリー2008
- Author(s)
  宮野拓也、川上茂、新留琢郎、橋田充
- Organizer
  第24回日本DDS学会
- Place of Presentation
  六本木アカデミーヒルズ
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Intranasally Administered CpG DNA /Cationic Liposome Complexes Prevents Lung Metastases in Mice2008
- Author(s)
  Shuwen Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜シンポジア(神奈川)
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] カタラーゼデリバリーによる癌の接着抑制2008
- Author(s)
  古林裕貴、西川元也、橋田充
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Intranasally Administered CpG DNA/Cationic Liposome Complexes Prevents Lun Metastases in Mice2008
- Author(s)
  Shuwen-Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜シンポジア
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] 樹状細胞選択的遺伝子送達キャリアを用いた新規DNAワクチン療法の開発2006
- Author(s)
  川上茂、橋田充
- Organizer
  第65回日本癌学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2006-09-29
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] 薬物治療とドラッグデリバリーシステム
- Author(s)
  橋田　充
- Organizer
  薬工連携セミナー
- Place of Presentation
  立命館大学びわこくさつキャンパス（滋賀県）
- Invited
- Data Source
  KAKENHI-PROJECT-23659284

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Hashida Mitsuru 橋田 充

HASHIDA Mitsuru 橋田 充

橋田 満 ハシダ ミツル

Research Projects

Research Products

Co-Researchers

Development of safety evaluation system for DDS carrier based on network toxicologyPrincipal Investigator

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Cell surface modification using non-natural amino acid and its application to drug delivery systemPrincipal Investigator

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Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cellPrincipal Investigator

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腫瘍関連マクロファージへの核酸ＤＤＳの開発Principal Investigator

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Therapeutic strategy of drug delivery systems utilizing unique tumor environmentPrincipal Investigator

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Long-term gene expression in primary cells by transposon and its application for cell therapyPrincipal Investigator

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トランスポゾンを用いたin vivo遺伝子発現長期化による新規慢性疾患療法の開発Principal Investigator

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免疫細胞指向性ナノ粒子によるNFkB転写制御と移植拒絶抑制への応用Principal Investigator

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Development of gene carriers based on in vivo and intracellular distribution real-time analysisPrincipal Investigator

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Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasisPrincipal Investigator

Principal Investigator

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NFκB活性化抑制に基づく新しい臓器移植における拒絶抑制法の開発Principal Investigator

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活性酸素消去酵素の細胞選択的ターゲティング・遺伝子導入によるがん転移抑制Principal Investigator

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New therapeutic strategies for treatment of cancer based on basic research

Principal Investigator

Hashida Mitsuru 橋田充

HASHIDA Mitsuru 橋田充

橋田満ハシダミツル