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Ishihara Kumatoshi  石原 熊寿

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ISHIHARA Kumatoshi  石原 熊寿

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Researcher Number 20212912
Other IDs
External Links
Affiliation (Current) 2025: 広島国際大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2016: 広島国際大学, 薬学部, 教授
2002: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授
1999 – 2001: Hiroshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授
1995 – 1998: Hiroshima Univ.Sch.of Med.Assistant Professor, 医学部, 講師
1989 – 1991: Fac. of Med., Kyoto Univ. Instructors, 医学部, 助手
Review Section/Research Field
Principal Investigator
General pharmacology
Except Principal Investigator
General pharmacology / 応用薬理学・医療系薬学 / Neurosurgery / Biological pharmacy
Keywords
Principal Investigator
パッチクランプ / CAl野 / 電撃痙攣処置 / 5-HT_<1A>受容体 / 細胞内記録 / 海馬スライス / シナプス伝達 / 電撃痙攣ショック処置 / グルタミン酸 / 5-HT_3受容体 … More / セロトニン / ニカルジピン / 急性単離神経細胞 / カルシウムチャネル / CA3 / 海馬 / 自然発症てんかんラット … More
Except Principal Investigator
カルシウムチャネル / パッチクランプ法 / SER / Ca^<2+> channel / トレモアラット / 自然発症てんかんラット(SER) / CNK-602A / 欠神様発作 / 強直性けいれん / 自然発症てんかんラット / Caudate nucleus / 尾状核 / c-Fos / mechanism / noda epileptic rat / vagus nerve stimulation / 強直間代性けいれん / 非定型欠神発作 / Vagal nerve stimulation / Noda epileptic rat / Ascending arousal system / 迷走神経刺激術 / Noda Epileptic Rat / Epilepsy / Vagus nerve stimulation / Intracellular recording / Dopamine receptor / Muscarinic receptors / Acetylcholine / Vestibular nucleus / 細胞内記録 / ド-パミン受容体 / ムスカリン受容体 / アセチルコリン / 前庭神経核 / muscle atrophy / clinical pharmacy / pharmacology / exocytosis / RBL-2H3 cells / mast cells / histamine / infrared laser-spectromicroscope / 薬効解析 / 臨床薬学 / アポトーシス / 廃用性筋萎縮 / ヒスタミン / RBL-2H3細胞 / マスト細胞 / アレルギー反応 / 近赤外レーザー顕微鏡 / GABA_A receptor / metabotropic glutamate receptor / N-acetyl aspartate / aspartoacetylase gene / epileptic seizure / tremor rat / ASP遺伝子 / パッチクランプ / 海馬CA3ニューロン / アスパルトアセチレース / N-アセチルアスパルテート / GABA_A受容体 / Ca^<2+>チャネル / 代謝型グルタミン酸受容体 / N-アセチルアスパルテート(NAA) / アスパルトアセチレース遺伝子 / てんかん発作 / tm gene / spontaneously epileptic rat (SER) / nifedipine / aspartpacetylase / calcium influx / hippocampal CA3 / fura / CaィイD12+ィエD1 channel / Syb2 / 海馬CA3細胞 / グルタミン酸 / パッチクランプホールセル記録 / トピラメート / Fura2-AM / ホールセルパッチクランプ / カルシウム電流 / ニカルジピン / tm因子 / ニフェジピン / アスパルトアセチラーゼ / カルシウム流入 / 海馬CA3 / fura2 / Ca^<2+> channel abnormality / depolarization shift / high-amplitude spike / autosomal recessive gene / audiogenic seizure / acoustic priming / epileptic model animal / Noda epileptic rat (NER) / 高電位棘波群発 / 強直-間代性けいれん / 音誘発発作 / 高振幅スパイク / ノダてんかんラット(NER) / Ca^<2+>チャネル異常 / 脱分極シフト / 音振幅スパイク / 常染色体劣性遺伝 / 聴原性発作 / 音刺激プライミング / てんかんモデル動物 / ノダてんかんラット / Ca^<2+> antagonist / TRH analogue / Absence-like seizure / Tonic convulsion / Spontaneously epileptic rats / チッターラット / 遺伝子解析 / 発作自動記録 / カルシウム拮抗薬 / TRH類緑体 / long-term-intake / plasma concentration of drug / prolongation of survival / vaporate / absence-like seizure / tonic convulsion / spontaneously epileptic rat / 強直性けいれん発作 / 血中濃度 / バルブロ酸 / 長期摂取効果 / 抗てんかん薬 / 長期摂取 / バルプロ酸(VPA) / 血漿中濃度 / 延命効果 / 長期効果 / パルプロ酸 / Dopamine D-2 receptor / Potassium ion channel / Muscarinic receptor / Adrenal chromaffin cell / Patch clam method / Software for analysis of electric signals / Electric signals of nerve cells / カリウムチャネル / クロマフィン細胞 / 副腎髄質 / ソフトウェア / 細胞電気信号 / ド-パミンDー2受容体 / カリウムイオンチャンネル / ムスカリン性受容体 / 副腎髓質クロマフィン細胞 / 電気信号解析用ソフトウェア / 神経細胞電気信号 / キスカル酸 / カイニン酸 / AMPA / NMDA / 単離ニュ-ロン / 前庭神経内側核 / グルタミン酸レセプタ- / 6ーヒドロキシド-パミン / ノルアドレナリン前駆体 / レ-スレオドプス / 仙髓ニュ-ロン / 青斑核 / 中枢ノルアドレナリン系 / 排尿障害 Less
  • Research Projects

    (13 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (19 People)
  •  Research for the mechanism of vagus nerve stimulation therapy using Noda epileptic rat

    • Principal Investigator
      Koji Iida
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hiroshima University
  •  Development of a new type of infrared laser-spectromicroscope and its application to analysis of molecular mechanisms in cells and tissues.

    • Principal Investigator
      OZAWA Koichiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Pharmacological research on Ca^<2+> channel abnormality which induces epileptic seizures

    • Principal Investigator
      SASA Masashi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  うつ病治療の電撃痙攣処置による海馬セロトニン受容体機能亢進機構の電気生理学的解明Principal Investigator

    • Principal Investigator
      石原 熊寿
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Hiroshima University
  •  Pharmacological research on CaィイD12+ィエD1 channel abnormality which induces epileptic seizures.

    • Principal Investigator
      SASA Masashi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Hiroshima University
  •  Development and pharmacological application of a newly genetic epilepsy rat (NER)

    • Principal Investigator
      SASA Masahi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  自然発症てんかんラット海馬錐体細胞異常電流発生機構のパッチクラインプ法による解明Principal Investigator

    • Principal Investigator
      石原 熊寿
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Hiroshima University
  •  Production under control of microorganism and pharmacological use of spontaneously epileptic rats.

    • Principal Investigator
      SASA Masashi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  単離前庭神経内側核ニュ-ロンにおけるグルタミン酸レセプタ-の証明

    • Principal Investigator
      SASA Masashi
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto University
  •  排尿障害に対する中枢ノルアドレナリン系の関与とレ-スレオドプスによる修復

    • Principal Investigator
      TAKAORI Shuji
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kyoto University
  •  Establishment of evaluation of long-term effects of antiepileptic drugs in the spontaneously epileptic rat

    • Principal Investigator
      SASA Masashi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kyoto University
  •  Development of Software for Automatic Analysis of Electric Signals of the Nerve Cells Recorded by Patch Clamp Method

    • Principal Investigator
      TAKAORI Shuji
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      General pharmacology
    • Research Institution
      Kyoto University
  •  Specificity of function of acetylcholinergic receptors in the caudate and vestibular nuclei.

    • Principal Investigator
      TAKAORI Shuji
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      KYOTO UNIVERSITY

All 2016 2015

All Presentation

  • [Presentation] Noda epileptic rat のてんかん発作に対する迷走神経刺激による発作抑制効果2016

    • Author(s)
      片桐匡弥、石原熊寿、飯田幸治、香川幸太、橋詰顕、原田佳奈、庫本高志、栗栖薫
    • Organizer
      第39回日本てんかん外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-26462210
  • [Presentation] Noda epileptic rat (NER)のてんかん発作に対する迷走神経刺激による発作抑制効果2015

    • Author(s)
      片桐匡弥、石原熊寿、飯田幸治、香川幸太、橋詰顕、原田佳奈、庫本高志、栗栖薫
    • Organizer
      第74回日本脳神経外科学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-26462210
  • 1.  SASA Masashi (20025654)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 2.  SERIKAWA Tadao (30025655)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  MATSUBAYASHI Hiroaki (60165850)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  UJIHARA Hisamitsu (00213421)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TAKAORI Shuji (10025538)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  MOMIYAMA Toshihiko (20230055)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YAMADA Junzo (90025651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KOHNO Shizuko (30034028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  AMANO Taku (10294547)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OZAWA Koichiro (10211822)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOSHII Michiko (40230677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MASUJIMA Tsutomu (10136054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HARA Mitsuyoshi (50192282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  AKAIKE Akinori (80135558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Koji Iida (20304412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  KATAGIRI Masaya (40793451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  香川 幸太 (40726981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  YAMAMOTO Toshiyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NODA Atsushi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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