TAKATOKU Masaaki 高徳正昭

Researcher Number	20285787
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2004 – 2005: 自治医科大学, 医学部, 講師 2002 – 2003: 自治医科大学, 医学部, 助手 1997 – 1998: Jichi Medical School, Assistant, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator 慢性肉芽腫症 / 遺伝子治療 / iBMT / SAG / CGD / gene therapy / 造血幹細胞移植 / 選択的増幅遺伝子 / 骨髄内移植 / 幹細胞増幅 … More / 造血幹細胞 / 臍帯血細胞 / エリスロポエチン受容体 / トロンボポエチン受容体 / トロンボポエチン / クロストーク / 赤芽球分化 / EPOR / 巨核球分化 / シグナル伝達 / C-mpl / TPC … More Except Principal Investigator GATA-1 / UT-7 / transgenic mice / 赤芽球分化 / STAT 1 / STAT 3 / megakaryocytic differentiation / erythroid differentiation / erythropoietin / 顆粒球・マクロファージコロニー刺激因子 / WAF-1 / p21 / 細胞周期 / チロシンキナーゼ / STAT蛋白 / MAPキナーゼ / トロンボポエチン / エリスロポエチン / STAT1 / STAT3 / 巨核球分化 / えりすろぽえちん / apoptosis / hemopoietic stem cell disorders / erythropoietin receptor / transcription factor / megakaryocytic cell line / erythropoietin gene / hemopoietic factor / hemopoietic stem cell / 赤白血病 / アポトーシス / STAT転写因子群 / 巨核球株細胞 / シグナル伝達 / 受容体 / 造血因子 / 造血幹細胞 Less

The technology development using selective amplified gene for chronic granulomatous disease for clinical application.Principal Investigator
- Principal Investigator
  
  TAKATOKU Masaaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  JICHI MEDICAL UNIVERSITY
ヒト臍帯血幹細胞を標的にした遺伝子導入および選択的増幅技術の基礎検討Principal Investigator
- Principal Investigator
  
  高徳正昭
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
トロンボポエチン受容体機能ドメインの解析とその下流シグナル分子の同定Principal Investigator
- Principal Investigator
  
  高徳正昭
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
analysis of molecular mechanism of hematopoiesis and hematological disorders
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jich Medical School
Molecular control of the regulation of hemopoiesis and clinical application
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  jichi Medical School

All 2005 2004 Other

All Journal Article

[Journal Article] Histone Deacetylase Inhibitor Despeptide(FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax,which is enhanced by the proteasome inhibitor Brotezomib.2005
- Author(s)
  Sutheesophon K, Kobayashi Y, Takatoku M, Ozawa K, Kano Y, Ishii H, Furukawa Y.
- Journal Title
  
  Acta Haematol 115
  
  Pages: 78-90
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Hematopoietic microchimerism in sheep after in utero transplantation of cultured cynomolgus embryonic stem cells2005
- Author(s)
  Sasaki K, Nagao Y, Takatoku M, et al.
- Journal Title
  
  Transplantation 79(1)
  
  Pages: 32-37
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Hematopoietic microchimerism in sheep after in utero transplamtation of cultured cynomolgus embryonic stem cells.2005
- Author(s)
  Sasaki K, Nagao Y, Takatoku M, at. al.
- Journal Title
  
  Transplantation 79
  
  Pages: 32-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Histone Deacetylase Inhibitor Depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor Bortezomib.2005
- Author(s)
  Sutheesophon K, Kobayashi Y, Takatoku M, Ozawa K, Kano Y, Ishii H, Furukawa Y.
- Journal Title
  
  Acta Haematol 115
  
  Pages: 78-90
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.2005
- Author(s)
  Laukkanen MO, Kuramoto K, Calmels B, Takatoku M, von Kalle C, Donahue RE, Dunbar CE.
- Journal Title
  
  Blood 105
  
  Pages: 1010-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Autologous gamete cryopreservation before hemopoietic stem cell transplantation.2005
- Author(s)
  Nagashima T, Muroi K, Kawano-Yamamoto C, Miyoshi T, Ohmine K, Toshima M, Miyazato A, Takatoku M, Nagai T, Mori M, Komatsu N, Ozawa K.
- Journal Title
  
  Med Sci Monit 11
  
  Pages: 91-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Autologous gamete cryopreservation before hemopoietic stem cell transplantation.2005
- Author(s)
  Nagashima T, Muroi K, Takatoku M, et al.
- Journal Title
  
  Med Sci Monit 11
  
  Pages: 91-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Hematopoietic microchimerism in sheep after in utero transplantation of cultured cynomolgus embryonic stem cells.2005
- Author(s)
  Sasaki K, Nagao Y, Kitano Y, Hasegawa H, Shibata H, Takatoku M, Hayashi H, Ozawa K, Hanazono Y.
- Journal Title
  
  Transplantation 79
  
  Pages: 32-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.2005
- Author(s)
  Laukkanen MO, Kuramoto K, Calmels B, Takatoku M, et al.
- Journal Title
  
  Blood 105
  
  Pages: 1010-5
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates2004
- Author(s)
  Ueda K, Hanazono Y, Takatoku M, et al.
- Journal Title
  
  Mol Ther 10(3)
  
  Pages: 469-477
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells2004
- Author(s)
  Laukkanen MO, Takatoku M, et al.
- Journal Title
  
  Blood 105(3)
  
  Pages: 1010-1015
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] High-Level in Vivo Gene Marking after Gene-Modified Autologous Hematopoietic Stem Cell Transplantation without Marrow Conditioning in Nonhuman Primates.2004
- Author(s)
  Ueda K, Hanazono Y, Shibata H, Ageyama N, Ueda Y, Ogata S, Tabata T, Nagashima T, Takatoku M, Kume A, Ikehara S, Taniwaki M, Terao K, Hasegawa M, Ozawa K.
- Journal Title
  
  Mol Ther 10(3)
  
  Pages: 469-477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] プロテアソーム阻害剤bortezomibが奏効したサリドマイド抵抗性難治性多発性骨髄腫2004
- Author(s)
  高徳正昭, ほか7名
- Journal Title
  
  臨床血液 45(2)
  
  Pages: 144-148
- NAID
  10012841869
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Treatment with a proteasome inhibitor, bortezomib, for thalidomide-resistant multiple myeloma.2004
- Author(s)
  Takatoku M, Noborio-Hatano K, Takahashi S, Kikuchi S, Mori M, Muroi K, Komatsu N, Ozawa K.
- Journal Title
  
  Jpn J Clin Hematol 45(2)
  
  Pages: 144-148
- NAID
  10012841869
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Involvement of the esophagus and stomach as a first manifestation of varicella zoster virus infection after allogeneic bone marrow transplantation2004
- Author(s)
  Takatoku M, Muroi K, et al.
- Journal Title
  
  Intern Med 43(9)
  
  Pages: 861-864
- NAID
  130000085100
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] High-Level in Vivo Gene Marking after Gene-Modified Autologous Hematopoietic Stem Cell Transplantation without Marrow Conditioning in Nonhiman Primates.2004
- Author(s)
  Ueda K, Hanazono Y, Shibata H, Ueda Y, Ogata S, Nagashima T, Takatoku M, et al.
- Journal Title
  
  Mol Ther 10
  
  Pages: 469-77
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Severe hepatitis and coplete molecular response caused by imatinib mesylate : possible association of its serum concentration with clinical outcomes.2004
- Author(s)
  Kikuchi S, Muroi K, Takahashi S, Kawano-Yamamoto C, Takatoku M, Miyazato A, Nagao T, Mori M, Komatsu N, Ozawa K.
- Journal Title
  
  Leuk Lymphoma 45(11)
  
  Pages: 2349-2351
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Involvement of the esophagus and stomach as a first manifestation of varicella zoster virus infection after allogeneic bone marrow transplantation.2004
- Author(s)
  Takatoku M, Muroi K, Yamamoto CK, Nagai T, Komatsu N, Ozawa K.
- Journal Title
  
  Internal Med 43(9)
  
  Pages: 861-864
- NAID
  130000085100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Involvement of the esophagus and stomach as a first manifestation of varicella zoster virus infection after allogeneic bone marrow transplantation2004
- Author(s)
  Takatoku M, Muroi K, Yamamoto CK, Nagata T, Komatsu K, Ozawa K.
- Journal Title
  
  Internal Med 43
  
  Pages: 861-4
- NAID
  130000085100
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Severe hepatitis and coplete molecular response caused by imatinib mesylate : possible association of its serum concentration with clinical outcomes.2004
- Author(s)
  Kikuchi S, Muroi K, Takahashi S, Kawano-Yamamoto C, Takatoku M, et al.
- Journal Title
  
  Leuk Lymphoma 45
  
  Pages: 2349-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] Severe hepatitis and complete molecular response caused by imatinib mesylate : possible association of its serum concentration with clinical outcome2004
- Author(s)
  Kikuchi S, Muroi K, Takatoku M, et al.
- Journal Title
  
  Leuk Lymphoma 45(11)
  
  Pages: 2349-2351
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] The usefulness of magnetic resonance imaging (MRI) for disseminated Trichosporosis of the gastrocnemius muscles.
- Author(s)
  Meguro-Hashimoto A, Takatoku M, Ohmine K, Toshima M, Mori M, Nagai T, Muroi K, Ozawa K.
- Journal Title
  
  J Infection (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590960
[Journal Article] The usefulness of magnetic resonance imaging (MRI) for disseminated Trichosporosis of the gastrocnemius muscles.
- Author(s)
  Meguro-Hashimoto A, Takatoku M, Ohmine K, et al.
- Journal Title
  
  J Infection (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590960

1. KOMATSU Norio (50186798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 清水律子 (40226262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MIURA Yasusada (60048965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MUROI Kazuo (50190939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IMAGAWA Shigehiko (60231164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HATAKE Kiyohiko (80192699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KASHII Yoshifumi (10271222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UCHIDA Mie (80316520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KIRITO Keita (90306150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UEDA Masuzu (60364501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

TAKATOKU Masaaki 高徳 正昭

Research Projects

Research Products

Co-Researchers

The technology development using selective amplified gene for chronic granulomatous disease for clinical application.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト臍帯血幹細胞を標的にした遺伝子導入および選択的増幅技術の基礎検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

トロンボポエチン受容体機能ドメインの解析とその下流シグナル分子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

analysis of molecular mechanism of hematopoiesis and hematological disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular control of the regulation of hemopoiesis and clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Histone Deacetylase Inhibitor Despeptide(FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax,which is enhanced by the proteasome inhibitor Brotezomib.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hematopoietic microchimerism in sheep after in utero transplantation of cultured cynomolgus embryonic stem cells2005

Author(s)

Journal Title

Data Source

[Journal Article] Hematopoietic microchimerism in sheep after in utero transplamtation of cultured cynomolgus embryonic stem cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Histone Deacetylase Inhibitor Depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor Bortezomib.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Autologous gamete cryopreservation before hemopoietic stem cell transplantation.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Autologous gamete cryopreservation before hemopoietic stem cell transplantation.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hematopoietic microchimerism in sheep after in utero transplantation of cultured cynomolgus embryonic stem cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates2004

Author(s)

TAKATOKU Masaaki 高徳正昭