MATSUOKA Shuji 松岡周二

… Alternative Names

松岡周二マツオカシュウジ

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Researcher Number	20286743
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 医学部, 特任准教授 2015 – 2017: 順天堂大学, 医学部, 助教 2011: 順天堂大学, 医学部, 助教 2009 – 2011: 順天堂大学, 医学部, 准教授 2003 – 2005: 順天堂大学, 医学部, 助手 2000 – 2001: 順天堂大学, 医学部, 助手 1997 – 1998: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Immunology / Tumor therapeutics Except Principal Investigator Laboratory animal science / Basic Section 56010:Neurosurgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56050:Otorhinolaryngology-related / Experimental pathology / Human pathology
Keywords	Principal Investigator RE2 / cell death / 細胞死 / アポトーシス / apoptosis / MHCクラスI / Death Receptor / MHC classs II / 抗体治療薬 / NKリンフォーマ … More / 悪性リンパ腫治療抗体 / humanized m Ab / Adult T cell Leukemia / lymphoma / therapy / monoclonal antibody / Anapocosis / 成人T細胞白血病 / 悪性リンパ腫 / 細胞骨格 / 汎HLA- class II / モノクローナル抗体 / 治療 / アナポコーシス / atopy / fulminant hepatitis / MHC class l / アトピー / 劇症肝炎 / Fulminant Hepatitis / perforin / MHC class I / パ-フォリン / パーフォリン … More Except Principal Investigator dbpA / Th1 / G-CSF / 抗体療法 / 個別化 / 個別化抗体療法 / 完全ヒト抗体産生マウス / 神経膠芽腫 / Monoclonal antibody / Targeted Treatment / LAR type / Basal 2 type / Triple negative / Helios / Ikzf2 / ENU-mutagenesis / Ikzf2 / Helios / 遺伝性難聴 / 自己免疫疾患 / 調節性T細胞 / environmental carcinogenesis / VB-1 / Hereditary cancer / inflammation / multistep carcinogenesis / hepatocarcinogenesis / chronic hepatitis / HCV / HBV / 肝がん / dhpA / 高がん化状態 / YB-1 / 環境発がん / VR-1 / 遺伝性がん / 多段階発がん / 炎症 / 肝発がん / 慢性肝炎 / Intreagenic recombination / H-2 congenic mice / E molecules / MNC class II / New zealand mice / Systemic lupus erthematosus (SLE) / recombinantマウス / congenicマウス / Class II / MHC / NewZealandマウス / intragenic recombination / H-2 congenicマウス / E分子 / MHC Class II / New Zealandマウス / 全身性エリテマトーデス(SLE) / Th2 balance / (NZB x NZW) F1 mouse / susceptibility gene / linkage analysis / lupus nephritis / gene polymorphism / G-CSF receptor / 自己抗体産生 / IL-4 / 連鎖解 / Th2バランス / (NZB x NZW)F1マウス / 感受性遺伝子 / 連鎖解析 / ループス腎炎 / 遺伝子多型 / G-CSFレセプター / 遺伝子 / ゲノム / 病理学 / 発生・分化 / 癌 / DDAH2 / がん間質細胞 / 胎児ブタ / モノクローナル抗体 / 肺腺がん / Dimethylarginie dimethlaminohydrolase 2(DDAH2) / 細気管支肺胞上皮癌 / 異型腺腫様過形成病変(AAH) / tumor-initiating cell / 肺腺癌 Less

トリプルネガティブ乳癌に対する新規治療抗体の樹立
- Principal Investigator
  
  水谷奈津子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyorin University
神経膠芽腫に対する新規個別化抗体療法の開発
- Principal Investigator
  
  大倉英浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Juntendo University
Pathogenesis of hearing impairment through autoimmune reaction by Treg regulatory factor Helios mutations
- Principal Investigator
  
  田中久美子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Juntendo University
Establishment of therapeutic mAbs for malignant lymphomaPrincipal Investigator
- Principal Investigator
  
  MATSUOKA Shuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Juntendo University
Identification of initiating cells of lung adenocarcinoma, analysis of its characteristics and application to therapy of lung adenocarcinoma.
- Principal Investigator
  
  ANAMI Yoichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Juntendo University
Molecular mechanism of hypercarcinogenic state -inflammation-induced hepatocarcinogenesis-
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  JUNTENDO UNIVERSITY
Role of G-CSF and C-CSF receptor gene polymorphisms for the development of lupus nephritis
- Principal Investigator
  
  HIROSE Sachiko, 姜奕
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  JUNTENDO UNIVERSITY
The role of MHC sub-region in autoimmune susceptibility and suppressor CD8 T cells
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  JUNTENDO UNIVERSITY
A Novel Type of Cell Death of Lymphocytes induced by mAbPrincipal Investigator
- Principal Investigator
  
  MATSUOKA Shuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
A Novel Type of Cell Death of Lymphocytes Induced by mAbPrincipal Investigator
- Principal Investigator
  
  MATSUOKA Shuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University

All 2017 2016 2015 2010 2004 2003

All Journal Article Presentation Patent

[Journal Article] 2.Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016
- Author(s)
  Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O.
- Journal Title
  
  PLoS One.
  
  Volume: 11(3)
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06880
[Journal Article] Establishment of anti-mesothelioma monoclonal antibodies.2016
- Author(s)
  Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O.
- Journal Title
  
  BMC Res Notes.
  
  Volume: 9 Pages: 324-324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06880
[Journal Article] Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016
- Author(s)
  Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O.
- Journal Title
  
  PLoS One.
  
  Volume: 11(3)
- NAID
  120005838168
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06880
[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.2004
- Author(s)
  Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, et al.
- Journal Title
  
  Hum Mol Genet. 13.2
  
  Pages: 171-179
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.2004
- Author(s)
  Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, et al.
- Journal Title
  
  Hum Mol Genet. 13
  
  Pages: 171-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.2004
- Author(s)
  Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S.
- Journal Title
  
  Hum.Mol.Genet. 13
  
  Pages: 171-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Gain-of-function polymorphism in mouse and human LtK : implications for the pathogenesis of systemic lupus erythematosus.2004
- Author(s)
  Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, et al.
- Journal Title
  
  Hum Mol Genet. 13
  
  Pages: 171-179
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] A monoclonal antibody to the α2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.2003
- Author(s)
  S.Matsuoka, et al.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 497-503
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] A monoclonal antibody to the a2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.2003
- Author(s)
  Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Shirai T.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 497-503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.2003
- Author(s)
  Matsuoka S, Tsurui H, Abe M, et al.
- Journal Title
  
  J Exp Med. 198
  
  Pages: 3497-3503
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Patent] 抗CD10抗体2017
- Inventor(s)
  水谷奈津子、安倍雅明、松岡周二
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15K06880
[Patent] Therapeutic Agent for Malignant Tumors Expressing MHC class II2015
- Inventor(s)
  松岡周二、石井保之
- Industrial Property Rights Holder
  順天堂大学, 理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-05
- Acquisition Date
  2016-04-05
- Overseas
- Data Source
  KAKENHI-PROJECT-15K06880
[Patent] THERAPEUTIC AGENT FOR MALIGNANT TUMORS EXPRESSING MHC CLASS II2015
- Inventor(s)
  Shuji Matsuoka, Yasuyuki Ishii
- Industrial Property Rights Holder
  順天堂大学, 理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Acquisition Date
  2016-02-19
- Overseas
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Cell death of activated lymphocytes and lymphoma/leukemia cells induced by MHC class I and II mAbs (Anapocosis)2017
- Author(s)
  松岡周二
- Organizer
  日本癌学会（第76回日本癌学会学術総会シンポジウム）
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] 悪性リンパ腫細胞やATL細胞をアナポコーシス（Anapocosis)によって破壊する治療抗体2017
- Author(s)
  松岡周二
- Organizer
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Anapocosis: Direct cell death lymphoma cells induced by mAbs2017
- Author(s)
  Shuji Matsuoka, Hideo Yagita, Koichiro Uchida
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Non Apoptotic,Non Necrotic Novel Cell Death (Anapocosis) of Lymphoma Cells Induced by Therapeutic mAb2016
- Author(s)
  松岡周二
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] 悪性中皮腫に対する新規抗体作製2016
- Author(s)
  水谷奈津子　松岡周二　阿部雅明　梶野一徳　脇屋緑　大辻奈穂美、森本幾夫、樋野興夫
- Organizer
  動物モデル研究の新たな可能性
- Place of Presentation
  琵琶湖ホテル（　滋賀県　大津市）
- Year and Date
  2016-02-04
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] アナポコーシス（ある種の抗体は腫瘍細胞に巨大な穴をあけて補体やカスペース非依存性に殺す）2016
- Author(s)
  松岡周二
- Organizer
  第25回日本Cell Death 学会
- Place of Presentation
  品川区立総合区民会館
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Cell death of activated lymphocytes and lymphoma/leukemia cells induced by MHC class I and class II mAbs2016
- Author(s)
  松岡周二　水谷奈津子
- Organizer
  動物モデル研究の新たな可能性
- Place of Presentation
  琵琶湖ホテル（　滋賀県　大津市）
- Year and Date
  2016-02-04
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Non Apoptotic, Non necrotic Novel Cell Death of Lymphoma Cells Induced by Therapeutic Mobs2016
- Author(s)
  Shuji Matsuoka
- Organizer
  BIT’s 7th World Gene Convention-2016 Shanghai, China 2016 November
- Place of Presentation
  Sheraton Shanghai Waigaoqiao Hotel, China
- Year and Date
  2016-11-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Establishment of a therapeutic anti-pan HLA-class II monoclonal antibody that directly induces lymphoma cell death via large pore formation.2016
- Author(s)
  Shuji Matsuoka
- Organizer
  International Congress of Immunology
- Place of Presentation
  Melbourne Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] 抗汎HLA class II抗体はリンパ腫細胞、ATL細胞、患者DLBCL細胞をアナポコーシスで殺す。2016
- Author(s)
  松岡周二
- Organizer
  第23回福岡血液研究会　２０１６年１１月
- Place of Presentation
  タカクラホテル福岡８階「真珠」
- Invited
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] 抗汎MHC モノクローナル抗体はリンパ腫やATL,の細胞株だけでなく、患者の白血化したリンパ腫細胞もアナポコーシスで殺した2016
- Author(s)
  松岡周二
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Cytolytic anti-pan HLA class II mAb and anti-MHC class I mAb directly induce lymphoma cell death via large pore formation2015
- Author(s)
  MATSUOKA Shuji, YAGITA Hideo, ISHII Yasuyuki
- Organizer
  第44回日本免疫学会
- Place of Presentation
  Sapporo Convention Center （　北海道　札幌市）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Establishment of new therapeutic Abs for Malignant Mesothelioma2015
- Author(s)
  Natsuko Mizutani, Shuji MATSUOKA, Kazunori KAJINO, Midori WAKIYA, Okio HINO
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋国際会議場（　愛知県　名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] Anti-pan MHC class I and class II mAbs directly induce lymphoma cell death via large pore formation2015
- Author(s)
  Shuji Matsuoka, Natsuko Mizutani, Hisashi Arase, Okio Hino
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋国際会議場（　愛知県　名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K06880
[Presentation] 急性リンパ性白血病再発後、亜急性連合変性症を合併したダウン症候群の1剖検例2010
- Author(s)
  里見介史、松岡健太郎、大喜多肇、森下由紀雄、野口雅之、吉田眞理、中川温子
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21590406

1. HIROSE Sachiko (00127127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. ANAMI Yoichi (40317376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NOGUCHI Masayuki (00198582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ISHIKAWA Sho (00276479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSURUI Hiromichi (40217386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ZHANG Danqing (40296877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HINO Okio (90127910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJII Hiroaki (50296836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KJINO Kazunori (80260066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 姜奕 (50276466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 小松則夫 (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 田中久美子 (40836243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 美野輪治 (00181967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 池田勝久 (70159614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 水谷奈津子 (10850076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 堀本義哉 (40424246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大倉英浩 (60384046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ABE Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. TOYOTA Tokuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MATSUOKA Shuji 松岡 周二

松岡 周二 マツオカ シュウジ

Research Projects

Research Products

Co-Researchers

トリプルネガティブ乳癌に対する新規治療抗体の樹立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経膠芽腫に対する新規個別化抗体療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis of hearing impairment through autoimmune reaction by Treg regulatory factor Helios mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of therapeutic mAbs for malignant lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of initiating cells of lung adenocarcinoma, analysis of its characteristics and application to therapy of lung adenocarcinoma.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of hypercarcinogenic state -inflammation-induced hepatocarcinogenesis-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of G-CSF and C-CSF receptor gene polymorphisms for the development of lupus nephritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of MHC sub-region in autoimmune susceptibility and suppressor CD8 T cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Type of Cell Death of Lymphocytes induced by mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Type of Cell Death of Lymphocytes Induced by mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 2.Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of anti-mesothelioma monoclonal antibodies.2016

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.2004

Author(s)

MATSUOKA Shuji 松岡周二

松岡周二マツオカシュウジ