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Ootsu Kinya  大津 欣也

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OTSU Kinya  大津 欣也

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Researcher Number 20294051
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External Links
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 病院, 理事長
2025: 大阪大学, 大学院医学系研究科, 招へい教授
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人国立循環器病研究センター, 病院, 理事長
2021 – 2023: 国立研究開発法人国立循環器病研究センター, 病院, 理事長
2020: 大阪大学, 医学系研究科, 招へい教授
2018 – 2019: 大阪大学, 医学系研究科, 特任教授
2017: 大阪大学, 先導的学際研究機構, 招へい教授 … More
2017: 大阪大学, 医学(系)研究科(研究院), 招へい教授
2015 – 2016: 大阪大学, 未来戦略機構, 招へい教授
2007 – 2011: Osaka University, 医学系研究科, 准教授
2009: 大阪大学, 大学院・医学系研究科, 准教授
2007: 大阪大学, 大学院・医学研究科・医学部, 准教授
2006: Osaka University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授
2005 – 2006: Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授
1999 – 2005: Graduate School of Medicine, Osaka University, Assistant Professor, 医学系研究科, 助手
2004: 大阪大学, 大学院・医学系研究科医学部, 助手
2003: 大阪大学, 医学系研究科医学部, 助手
2002 – 2003: 大阪大学, 医学系研究科・医学部, 助手
2000: 大阪大学, 大学院・医学研究科, 助手
1999: Osaka University Graduate School of Medicine, Assistant Professor
1997 – 1998: 大阪大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / Circulatory organs internal medicine / Circulatory organs internal medicine / Cardiovascular medicine / Biological Sciences
Except Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Neurophysiology and muscle physiology / General physiology
Keywords
Principal Investigator
心不全 / ミトコンドリア / オートファジー / 細胞死 / 心筋炎症 / 炎症 / ASK1 / knockout mice / sorcine / contraction-excitation coupling … More / Calcium / ノックアウトマウス / ソルシン / リアノジンレセプター / 興奮収縮連関 / カルシウム / Caシグナリング / カルパイン / カルシウムシグナリング / 心筋 / アポトーシス / DNAメチル化 / マイトファジー / DNA分解 / apoptosis / reactive oxygen species / heart failure / 心不全モデル動物 / 遺伝子治療 / 活性酸素種 / ryanodine receptor / トランスゲニックマウス / CaATPAse / 心肥大 / SERCA / ryanodine receptor, / gene expression / Sarcoplasmic reticulum / calpain / Ca release channel / Ca / Ca遊離チャネル / 筋小胞体 / コネクシン / カルシウム遊離チャネル / 遺伝子発現 / 心筋細胞死 / 細胞内分解系 / ネクローシス … More
Except Principal Investigator
Mn-SOD / ZO-1 / Connexin / 心不全 / TNF-α / 心筋細胞 / 筋小胞体 / Gap junction / Ca^<2+> / Heart Failure / mouse / Ca^<2+>トランジェント / マウス / SERCA2a / 心筋 / Cardioprotection / 心筋保護 / 心筋梗塞 / 細胞障害 / プレコンディショニング / 酸化ストレス / Cardiac myocytes / パッチクランプ法 / Gap junctional Protein / カラーイメージィングシステム / sarcoplasmic reticulum / Ca遊離チャネル / p38 MAP Kinase / p38MAPキナーゼ / risk factors / epidemiology / prognosis / gene polymorphism / myocardial infarction / 危険因子 / 疫学研究 / 予後調査 / 遺伝子多型 / Ca^<2+> transients / cardiac muscle / saponin / skinned preparation / sarcolipin / 細胞内Ca^<2+> / 筋小胞体Caポンプ / カルシウム / ウエスタンブロッティン / サポニン / スキンド標本 / サルコリピン / Remodeling / Cardiac Hypertrophy / リモデリング / 心筋肥大 / acidosis / isoprenaline / Ca^<2+> transient / ryanodine receptor type2 / myocardium / intracellular Ca^<2+> / エクオリン / 遺伝子非改変マウス / 収縮蛋白系 / SERCA / Caポンプ / 張力 / 細胞内Ca transient / マウス心室筋 / Ca^<2+>transient / β受容体 / エクオリン法 / トロポニン / system patch-clamp methods / Ca imaging system / c-Src / 不全心 / パッチ・クランプ法 / Ca伝幡 / connexin43 / カラーイメージングシステム / Cardioprotective therapy / exercise / oxygen radicals / ischemia-reperfusion / IL / TNF / 虚血耐性 / 運動療法 / 心筋保護療法 / 運動負荷 / 活性酸素 / 虚血-再灌流 / IL-1β / cytokine / oxidative stress / hydrogen peroxide / Cardiac myocyte / DCFH / サイトカイン / 過酸化水素 / Clinical Trial / Cathecolamine / Ecto-5'-Nucleotidase / Adenosine / Stunning / Myocardial Infarction / protcin kinascC / ATP / 急性心筋梗塞 / prcconditioning現象 / 遺伝子導入 / ccto-5^I-nuclcotidasc / 虚血・再潅流 / 臨床試験 / トランスジェニックマウス / カテコラミン / アデノシン産生酵素 / アデノシン / スタニング / Inflammation / Oxidative Stress / Acute Coronary Syndrome / 温熱負荷 / 血管平滑筋細胞 / 炎症 / 急性冠症候群 / patch-clamp methods / Cai. aging system / パッチ・クランプシステム / 部位特異的変異導入法 / connexin-43 / gap junctional protein / ランプ法 / Gap Junctional Protein / gene expression / heart failure / phospholamban / Ca release channel / Ca signaling / 遺伝子診断 / 心筋症 / 筋小胞体カルシウム遊離チャネル / 興奮収縮連関 / カルシウムシグナリング / Caジクナリング / 遺伝子発現 / ホスホランバン / Caシグナリング / 遺伝子改変 / リン酸化調節 / 筋小胞体機能 / 細胞内Ca動態 / 心臓病態学 / 心肥大 / 適応破綻 / 時間特異的 / 心筋特異的 / Cre-loxP / p38α / 分化誘導 / 電気的リモデリング / Ca感受性 / 特発性心室細動 / チャネル遺伝子 / QT延長症候群 Less
  • Research Projects

    (26 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (37 People)
  •  心不全における線維芽細胞―心筋細胞間相互作用及びオートファジー性分解の寄与の解明Principal Investigator

    • Principal Investigator
      大津 欣也
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Elucidation of mitochondrial degradation mechanisms and their application to drug development for heart failurePrincipal Investigator

    • Principal Investigator
      Kinya Otsu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Investigation for a molecular regulatory mechanism inducing endogenous myocardial inflammationPrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  Integrated analyses of mitochondria degradation system as a novel therapeutic target of heart failurePrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  タンパク質分解系による心不全制御機構の解明Principal Investigator

    • Principal Investigator
      大津 欣也
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Role of intracellular degradation systems in genesis of heart failurePrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Elucidation of molecular mechanisms underlying cell death in heart failurePrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.

    • Principal Investigator
      HONGO Kenichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Jikei University School of Medicine
  •  Searching and validation of polymorphisms which are associated with prognosis after myocardial infarctton

    • Principal Investigator
      SATO Hiroshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Characterization of cardioprotective molecular mechanism via p38MAPK and new therapy for heart failure

    • Principal Investigator
      NISHIDA Kazuhiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      OSAKA UNIVERSITY
  •  Molecular mechanisms of Ca^<2+> uptake by sarcolipin in cardiac sarcoplasmic reticulum.

    • Principal Investigator
      KURIHARA Satoshi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Jikei University School of Medicine
  •  Elucidation of a role of ASK1 in the pathogenesis of heart failure and its application to therapeuticsPrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Gene expression profiling in hypertrophied heart as the determinant of phenotype of heart failure

    • Principal Investigator
      YAMAMOTO Kazuhiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  心筋及び時間息異的p38α改変マウスによる心肥大から心不全への適応破綻機序の解明

    • Principal Investigator
      MASUYAMA Tohru
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Molecular Mechanism for Excitation-contraction Coupling in Heart and its Pathophysiological SignificancePrincipal Investigator

    • Principal Investigator
      OTSU Kinya, 多田 道彦
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Intracellular Ca^<2+> regulation in the myocardium with ryanodine receptor type 2(+/-) heterozygous mouse

    • Principal Investigator
      KURIHARA Satoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Jikei University School of Medicine
  •  心臓血管系におけるチャネル病の発症と成因に関する調査・研究

    • Principal Investigator
      平岡 昌和
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Investigation of Molecular Mechanism for Excitation-contraction Coupling in HeartPrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Functional analysis of gap junction and its clinical application

    • Principal Investigator
      TOYOFUKU Toshihiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  The role of anti-oxidant enzyme in cardioprotective effects of exercise and heat stress

    • Principal Investigator
      KUZUYA Tsunehiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Molecular Mechanisms of Cardiac Gap Junction

    • Principal Investigator
      TADA Michihiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.

    • Principal Investigator
      HORI Masatsugu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Treatment of heart failure by modulating Ca signaling protein gene expressionPrincipal Investigator

    • Principal Investigator
      OTSU Kinya
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Molcular Mechanisms and Clinical Role of the Phosphorylation and Activation of Ecto-5'-Nucleotidase, Adenosine Producing Enzyme in Cardioprotection.

    • Principal Investigator
      KITAKAZE Masafumi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Intracellular signal transduction via acitive oxygen production in cardiac myocytes-role of redox regulation in Mn-SOD induction-

    • Principal Investigator
      NISHIDA Masashi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University
  •  Molecular Mechanism for Calcium Signaling in Cardiomyocyte

    • Principal Investigator
      TADA Michihiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload2022

    • Author(s)
      Akazawa Yasuhiro、Taneike Manabu、Ueda Hiromichi、Kitazume-Taneike Rika、Murakawa Tomokazu、Sugihara Ryuta、Yorifuji Hiroki、Nishida Hiroki、Mine Kentaro、Hioki Ayana、Omiya Shigemiki、Nakayama Hiroyuki、Yamaguchi Osamu、Yoshimori Tamotsu、Sakata Yasushi、Otsu Kinya
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 41-41

    • DOI

      10.1038/s41598-021-03920-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02913, KAKENHI-PROJECT-20K08448, KAKENHI-PROJECT-20K08491, KAKENHI-PROJECT-21K08104, KAKENHI-PROJECT-21K21350
  • [Journal Article] Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice2021

    • Author(s)
      Ito Jumpei、Omiya Shigemiki、Rusu Mara-Camelia、Ueda Hiromichi、Murakawa Tomokazu、Tanada Yohei、Abe Hajime、Nakahara Kazuki、Asahi Michio、Taneike Manabu、Nishida Kazuhiko、Shah Ajay M、Otsu Kinya
    • Journal Title

      eLife

      Volume: 10

    • DOI

      10.7554/elife.62174

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02807
  • [Journal Article] NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C <sup>hi</sup> monocytes in pressure-overloaded hearts2021

    • Author(s)
      Abe Hajime、Tanada Yohei、Omiya Shigemiki、Podaru Mihai-Nicolae、Murakawa Tomokazu、Ito Jumpei、Shah Ajay M.、Conway Simon J.、Ono Masahiro、Otsu Kinya
    • Journal Title

      Science Signaling

      Volume: 14 Issue: 704

    • DOI

      10.1126/scisignal.abe4932

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02913, KAKENHI-PROJECT-21K15277
  • [Journal Article] Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts2020

    • Author(s)
      Omiya Shigemiki、Omori Yosuke、Taneike Manabu、Murakawa Tomokazu、Ito Jumpei、Tanada Yohei、Nishida Kazuhiko、Yamaguchi Osamu、Satoh Takashi、Shah Ajay M.、Akira Shizuo、Otsu Kinya
    • Journal Title

      Circulation

      Volume: 141 Issue: 8 Pages: 667-677

    • DOI

      10.1161/circulationaha.119.044582

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02807
  • [Journal Article] Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice2019

    • Author(s)
      Hiromichi Ueda, Osamu Yamaguchi, Manabu Taneike, Yasuhiro Akazawa, Haruko Wada-Kobayashi, Ryuta Sugihara, Hiroki Yorifuji, Hiroyuki Nakayama, Shigemiki Omiya, MD, Tomokazu Murakawa, Yasushi Sakata, Kinya Otsu
    • Journal Title

      J Am Coll Cardiol Basic Trans Science

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02807
  • [Journal Article] FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.2018

    • Author(s)
      Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, Uno Y, Yamaguchi O, Takeda J, Shah AM, Otsu K.
    • Journal Title

      J Mol Cell Cardiol.

      Volume: 114 Pages: 93-104

    • DOI

      10.1016/j.yjmcc.2017.11.004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-15K09140
  • [Journal Article] Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases.2018

    • Author(s)
      Nakayama H, Otsu K.
    • Journal Title

      Biochem J.

      Volume: 475 Issue: 5 Pages: 839-852

    • DOI

      10.1042/bcj20170714

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-15H04822
  • [Journal Article] Sterile Inflammation and Degradation Systems in Heart Failure2017

    • Author(s)
      Nishida K, Otsu K.
    • Journal Title

      Circ J

      Volume: 81 Issue: 5 Pages: 622-628

    • DOI

      10.1253/circj.CJ-17-0261

    • NAID

      130005612036

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822
  • [Journal Article] Inflammation and metabolic cardiomyopathy.2017

    • Author(s)
      Nishida K, Otsu K.
    • Journal Title

      Cardiovasc Res.

      Volume: 113 Issue: 4 Pages: 389-398

    • DOI

      10.1093/cvr/cvx012

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822
  • [Journal Article] Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.2017

    • Author(s)
      Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis J.
    • Journal Title

      Circulation. 2017 Aug 8;136(6):549-561

      Volume: 136 Issue: 6 Pages: 549-561

    • DOI

      10.1161/circulationaha.116.026238

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822
  • [Journal Article] mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.2016

    • Author(s)
      Taneike M, Nishida K, Omiya S, Zarrinpashneh E, Misaka T, Kitazume-Taneike R, Austin R, Takaoka M, Yamaguchi O, Gambello MJ, Shah AM, Otsu K.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0152628-e0152628

    • DOI

      10.1371/journal.pone.0152628

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-15K09140
  • [Journal Article] Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation.2016

    • Author(s)
      Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 311 Issue: 6 Pages: H1485-H1497

    • DOI

      10.1152/ajpheart.00481.2016

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04822
  • [Journal Article] BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32.2015

    • Author(s)
      Otsu K, Murakawa T, Yamaguchi O.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 10 Pages: 1932-3

    • DOI

      10.1080/15548627.2015.1084459

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09140, KAKENHI-PROJECT-15H04822
  • [Journal Article] Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.2015

    • Author(s)
      Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 7527-7527

    • DOI

      10.1038/ncomms8527

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09140, KAKENHI-PROJECT-26461129, KAKENHI-PUBLICLY-15H01536, KAKENHI-PUBLICLY-26111513, KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-25650067, KAKENHI-PROJECT-25291045, KAKENHI-PROJECT-25713031
  • [Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure2012

    • Author(s)
      岡崇史、彦惣俊吾、山口修、種池学、武田理宏、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、審良静男、山本章次、小室一成、大津欣也
    • Journal Title

      Nature

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Journal Article] Calpain protects the heart from hemodynamic stress2011

    • Author(s)
      種池学、溝手勇、森田孝、渡部徹也、彦惣俊吾、山口修、武田理宏、岡崇史、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、竹田潤二、望月直樹、小室一成、大津欣也
    • Journal Title

      The Journal of Biological Chemistory

      Volume: 286 Pages: 32170-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010

    • Author(s)
      種池学、山口修、中井敦子、彦惣俊吾、武田理宏、溝手勇、岡崇史、玉井敬人、大藪丈太、村川智一、西田和彦、清水孝彦、堀正二、小室一成、白澤卓司、水島昇、大津欣也
    • Journal Title

      Autophagy

      Volume: 6 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Journal Article] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2009

    • Author(s)
      Shigemiki Omiya, Shungo Hikoso, Yukiko Imanishi, Atsuhiro Saito, Osamu Yamaguchi, Toshihiro Takeda, Isamu Mizote, Takafumi Oka, Manabu Taneike, Yuko Nakano, Yasushi Matsumura, Kazuhiko Nishida, Yoshiki Sawa, Masatsugu Hori, Kinya Otsu
    • Journal Title

      J. Mol. Cell. Cardiol 46

      Pages: 59-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008

    • Author(s)
      Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, PhD, Masayuki Taniike, Isamu Mizote, Yasushi Matsumura, Takahiko Shimizu, Kazuhiko Nishida, Kiyohiro Imai, Masatsugu Hori, Takuji Shirasawa, Kinya Otsu
    • Journal Title

      J. Am. Coll. Cardiol. 52

      Pages: 779-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Journal Article] Apoptosis signal-regulating kinase 1(ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy2008

    • Author(s)
      Masayuki Taniike, Osamu Yamaguchi, Ikuko Tsujimoto, Shungo Hikoso, Toshihiro Takeda, Atsuko Nakai, Shigemiki Omiya, Isamu Mizote, Yuko Nakano, Yoshiharu Higuchi, Yasushi Matsumura, Kazuhiro Nishida, Masatsugu Hori, Hidenori Ichijo, Kinya Otsu
    • Journal Title

      Circulation 117

      Pages: 545-552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Journal Article] Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer2007

    • Author(s)
      Shungo Hikoso, Yasuhiro Ikeda, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shinichi Hirotani, Kazunori Kashiwase, Michio Yamada, Michio Asahi, Yasushi Matsumura, Kazuhiko Nishida, Masunori Matsuzaki, Masatsugu Hori, Kinya Otsu
    • Journal Title

      J. Am. Coll. Cardiol 50

      Pages: 453-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Journal Article] The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress2007

    • Author(s)
      Atsuko Nakai, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shungo Hikoso, Masayuki Taniike, Shigemiki Omiya, Isamu Mizote, Yasushi Matsumura, Michio Asahi, Kazuhiko Nishida, Masatsugu Hori, Noboru Mizushima, Kinya Otsu
    • Journal Title

      Nature Medicine 13

      Pages: 619-624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Journal Article] Osaka Acute Coronary Insufficiency Study (OACIS) Group. Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.2006

    • Author(s)
      Mizuno H, Sato H, Sakata Y, Ohnishi Y, Hishida E, Kinjo K, Nakatani D, Shimizu M, Kondo H, Tanaka T, Ozaki K, Hirayama A, Ito H, Otsu K, Hori M
    • Journal Title

      Atherosclerosis. 185(2)

      Pages: 400-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590730
  • [Presentation] 多職種連携により心不全パンデミックに立ち向かう2023

    • Author(s)
      大津欣也
    • Organizer
      第16回日本在宅薬学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02913
  • [Presentation] 循環器病の克服を目指して2023

    • Author(s)
      大津欣也
    • Organizer
      日本循環器病予防学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02913
  • [Presentation] Cardiac inflammation and degradation systems2022

    • Author(s)
      大津 欣也
    • Organizer
      第26回 日本心血管内分泌代謝学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02913
  • [Presentation] Mitochondrial Degradation and Cardiac Inflammation2022

    • Author(s)
      大津欣也
    • Organizer
      第86回日本循環器学会学術集会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02913
  • [Presentation] 心臓炎症と細胞内分解システム2022

    • Author(s)
      大津 欣也
    • Organizer
      第27回 日本病態プロテアーゼ学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02913
  • [Presentation] The role of autophagy in cardiac remodelling2021

    • Author(s)
      大津欣也
    • Organizer
      第85回日本循環器学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02807
  • [Presentation] The molecular link between cell death and sterile inflammation2012

    • Author(s)
      大津欣也
    • Organizer
      7the Annual Winter Research Meeting on Translational Basic Science
    • Place of Presentation
      ル リアブレレッツ、スイス(招待講演)
    • Year and Date
      2012-01-19
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Molecular link between cell death and sterile inflammation2012

    • Author(s)
      大津欣也
    • Organizer
      ヨーロッパ心不全学会冬季研究学会
    • Place of Presentation
      スイス
    • Year and Date
      2012-01-19
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Inflammation and autophagy2011

    • Author(s)
      大津欣也
    • Organizer
      Basic Cardiovascular Sciences 2011 Scientific Sessions
    • Place of Presentation
      ニューオーリンズ、アメリカ合衆国(招待講演)
    • Year and Date
      2011-07-19
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Inflammation and autophagy2011

    • Author(s)
      大津欣也
    • Organizer
      基礎心臓病学カンファレンス、ラスベガス
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2011-07-19
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Autophagy as an adaptive mechanism to cardiac stress2010

    • Author(s)
      大津欣也
    • Organizer
      XXth World Congress of the International Society for Heart Research
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2010-05-15
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Autophagy and apoptosis in heart failure2010

    • Author(s)
      大津欣也
    • Organizer
      World Phama 2010
    • Place of Presentation
      コペンハーゲン、デンマーク(招待講演)
    • Year and Date
      2010-07-20
    • Data Source
      KAKENHI-PUBLICLY-21025018
  • [Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse.2009

    • Author(s)
      Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
    • Organizer
      XXXVIth International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19590833
  • [Presentation] Autophagy and apoptosis in heart disease2009

    • Author(s)
      大津欣也
    • Organizer
      ヨーロッパ心不全学会
    • Place of Presentation
      ニース、フランス
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Role of autophagy in heart failure2009

    • Author(s)
      Kinya Otsu
    • Organizer
      The 73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2009-03-20
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Presentation] MAPK Signaling and Regulation of Cardiac Hypertrophy2009

    • Author(s)
      大津欣也
    • Organizer
      基礎心臓病学カンファレンス、ラスベガス
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2009-07-20
    • Data Source
      KAKENHI-PROJECT-21390240
  • [Presentation] Altered Autophagy in Cardiomyopathy2008

    • Author(s)
      Kinya Otsu
    • Organizer
      European Society of Cardiology, Heart Failure
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Presentation] Altered Autophagy in Cardiomyopathy2008

    • Author(s)
      大津欣也
    • Organizer
      European Society of Cardiology, Heart Failure
    • Place of Presentation
      イタリア、ミラノ
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-19390214
  • [Presentation] Ablation of apoptosis signal-regulating kinase improves cardiac stress-resistance2007

    • Author(s)
      Otsu, K
    • Organizer
      European Society of Cardiology, Heart Failure
    • Place of Presentation
      ハンブルグ、ドイツ
    • Year and Date
      2007-06-10
    • Data Source
      KAKENHI-PROJECT-19390214
  • 1.  NISHIDA Masashi (40283783)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  KUZUYA Tsunehiko (80150340)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  NISHIDA Kazuhiko (90362681)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 4.  TOYOFUKU Toshihiko (60322179)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  MATSUMURA Yasushi (90252642)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  YAMAGUCHI Osamu (90467580)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 7.  TADA Michihiko (90093434)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  HIKOSO Shungo (30423164)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 9.  MASUYAMA Tohru (70273670)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  HONGO Kenichi (00256447)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 11.  KAWAI Makoto (40277025)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 12.  HORI Masatsugu (20124779)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KITAKAZE Masafumi (20294069)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  SATO Hiroshi (10294092)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 15.  KURIHARA Satoshi (90057026)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  KUSAKARI Yoichiro (80338889)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  YAMAMOTO Kazuhiro (90303966)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  種池 学 (30609756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 19.  KOMUKAI Kimiaki (60360145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  MIYAZAKI Jun-ichi (10200156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SATO Hideyuki (70167435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MIWA Takeshi (20174229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  平岡 昌和 (80014281)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  木村 彰方 (60161551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  堀江 稔 (90183938)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  児玉 逸雄 (30124720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  岡田 泰伸 (10025661)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  星田 四朗 (80238732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  田中 悦子 (70256410)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  MURAKAWA Tomokazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 31.  MINAMINO Tetsuo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  山下 宣繁
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  真野 敏昭
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  YASUI Hiroki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  UEDA Hiromichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  AKAZAWA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  中山 博之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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