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Tatsumi Tomohide  巽 智秀

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TATSUMI Tomohide  巽 智秀

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Researcher Number 20397699
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 大阪大学, 大学院医学系研究科, 准教授
2021: 大阪大学, 医学系研究科, 准教授
2016 – 2020: 大阪大学, 医学系研究科, 講師
2015: 大阪大学, 医学(系)研究科(研究院), 講師
2015: 大阪大学, 大学院医学系研究科, 講師 … More
2013 – 2014: 大阪大学, 大学院医学系研究科, 助教
2012 – 2014: 大阪大学, 医学(系)研究科(研究院), 助教
2013: 大阪大学, 大学院・医学系研究科, 助教
2008 – 2012: Osaka University, 医学系研究科, 助教
2011: 大阪大学, 医学系・研究科, 助教
2011: 大阪大学, 大学院・医学系研究科, 助教
2010: 大阪大学, 大学院・医学系研究科・消化器内科学, 助教
2007: Osaka University, Hospital, Assistant Professor
2006: Osaka University, Hospital, Assistant, 医学部附属病院, 助手
2005: 大阪大学, 医学研究科, 特任助手(常勤)
2005: Osaka University, Graduate School of Medicine Department of Gastroenterology and Hepatology, Specially Appointed Assistant, 医学系研究科, 特任助手(常勤) Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
肝癌 / 肝細胞癌 / α-galactosylceramide / EphA2 / 癌免疫 / 樹状細胞 / 脂肪肝 / リキッドバイオプシー / ベバシズマブ / アテゾリズマブ … More / ctDNA / cfDNA / IL-6 / 複合免疫療法 / 肝がん / バイオマーカー / 癌免疫療法 / 免疫学的解析 / ゲノム・トランスクリプトーム解析 / ドライバー遺伝子 / 腫瘍免疫 / 癌微小環境 / 免疫細胞 / 酸化ストレス / βカテニン / 遺伝子変異 / 癌ゲノム / 放射線障害 / 肝再生 / 放射線肝障害 / Interleukin 12 / Cancer Immunotherapy / Dendritic cell / Liver cancer / インターロイキン12 / 癌免疫治療 / 抗がん剤 / 低酸素 / 肝癌幹細胞 / 細胞周期 / 先天免疫 / 抗癌剤 / C型肝炎ウイルス / 癌幹細胞 / 肝癌免疫治療 / ナノテクノロジー … More
Except Principal Investigator
肝癌 / 肝細胞癌 / ノックアウトマウス / アポトーシス / オートファジー / 肝細胞 / NK細胞 / 脂肪肝 / 肝臓 / 細胞内輸送 / CTGF / C型肝炎 / NKG2D / MICA / 癌 / NASH / 脂肪生成 / 脂肪細胞 / MICB / ELISPOT / CTL / C型慢性肝炎 / Innate immunity / Liver / NKレセプター / 肝がん / 自然免疫 / 消化器内科学 / 非アルコール性脂肪性肝疾患 / 急性膵炎 / 肝細胞死 / Mcl-1 / Bcl-xL / 肝臓学 / ソラフェニブ / 免疫 / マウス / B型肝炎 / P53 / 肝前駆細胞 / 細胞老化 / p53 / TNF-alfa / 慢性膵炎 / TNF-α / 肝星細胞 / IL-6ファミリー分子 / GDF15 / 細胞間相互作用 / 肝癌微小環境 / 動物モデル / 膵前癌病変 / 膵癌進展 / 膵発癌 / 高血糖状態 / 糖尿病 / 膵癌 / 慢性肝疾患 / DNase II / ミトコンドリアDNA / 非アポトーシス型細胞死 / スクリーニング / CRISPR/Cas / EMT / 肝細胞がん / 脱分化 / Pten / Sav1 / トランスポゾン / CRISPR / 遺伝子スクリーニング / Hippo経路 / Tumor / NK receptor / HCC / Soluble MICB / Soluble MICA / 自然免 / TAE / 肝硬変 / Interferon therapy / Immuno-monitoring / Chronic hepatitis type C / インターフェロン / ELISPOT法 / インターフェロン治療 / 免疫モニタリング / Virus / Liver cancer / Hepatitis C / NK cell / Cancer / Immunology / 獲得免疫 / HLA-E / 先天免疫 / NKG2A / 樹状細胞 / ウイルス / 肝発癌 / 発癌 / Kras / 細胞極性 / アメリカ合衆国 / 国際情報交換 / Rab11a / 脂肪性肝疾患 / Rubicon / 顆粒球系細胞 / CXCR2 / CXCL1 / S100A8 / STAT3 / 膵炎 / マウスモデル / 肝繊維化 / 酸化ストレス / Atg-7 / Atg7 / 脂肪肝炎 / 非アルコール性脂肪肝炎 / Cre / ノックアウト / apoptosis / Bid / 肝線維化 / Bak / Bcl-2 / B型劇症肝疾患 / 薬剤耐性変異ウイルス / 核酸アナログ / インターフェロン-γ / HBV増殖活性 / 活動性B型肝炎発症 / 無症候性HBVキャリア / B型肝炎ウイルス変異 / B型肝炎ウイルス複製 / shedding / 抗癌剤 / 免疫治療 / sorafenib / MIC / 炎症 / IL-1 / ADAM / 自己消化 / 代謝疾患 / GFP-LC3 / 非アルコール性脂肪性肝炎 / 酵素抗体法 / LC3 / MCD / 抗ウイルス治療 / 遺伝子導入 / IFN / Precore変異 / YMDD変異 / 酵素阻害剤 / 遺伝子解析 / 耐性ウイルス / ラミブジン / HBV Less
  • Research Projects

    (35 results)
  • Research Products

    (455 results)
  • Co-Researchers

    (28 People)
  •  多層オミクスを起点とした肝代謝異常と再生不全をつなぐ分子機序の解明Principal Investigator

    • Principal Investigator
      巽 智秀
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Elucidation of hepatic progenitor cell-derived carcinogenic mechanism via p53 activation in hepatocytes

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Building personalised pharmacotherapy for liver cancer based on driver gene abnormalities.Principal Investigator

    • Principal Investigator
      Tatsumi Tomohide
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Intracellular transport in the progress of chronic liver disease

    • Principal Investigator
      Sakamori Ryotaro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinoma

    • Principal Investigator
      Hikita Hayato
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  The effect of elevated TNF-alfa on the pathogenesis of chronic pancreatitis

    • Principal Investigator
      Shigekawa Minoru
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Discovery of HCC progression-related cancer genes through in vivo forward genetic screen

    • Principal Investigator
      Takahiro Kodama
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease

    • Principal Investigator
      Hikita Hayato
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Intracellular trafficking in liver disease

    • Principal Investigator
      Sakamori Ryotaro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression

    • Principal Investigator
      Shigekawa Minoru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapyPrincipal Investigator

    • Principal Investigator
      Tatsumi Tomohide
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapyPrincipal Investigator

    • Principal Investigator
      Tatsumi Tomohide
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.

    • Principal Investigator
      Hayato Hikita
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Intracellular trafficking in the liver

    • Principal Investigator
      Ryotaro Sakamori
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  肥満に伴う慢性肝疾患NAFLDにおける免疫の関与とその制御に関する解析

    • Principal Investigator
      宮城 琢也
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  The role of NK cell in the patients with hepatitis C virus infection; analysis focusing on NK cell receptor and IFN signal transducer

    • Principal Investigator
      Kasahara Akinori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Continuous hepatocyte apoptosis induces HCC in the liver

    • Principal Investigator
      HIKITA Hayato
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  肝細胞CTGFによる肝線維化・肝発癌制御機構の解明

    • Principal Investigator
      Takahiro Kodama
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Regulation of liver innate immunnity in human hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      TATSUMI Tomohide
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Molecular mechanisms of acinar cell injury in acute pancreatitis

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Immunological analysis of liver cancer stem cells and immunotherapyPrincipal Investigator

    • Principal Investigator
      TATSUMI Tomohide
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Bcl-2 network and regulation of cell death in non-alcoholic steatohepatitis

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Molecular mechanism of the ectodomain shedding of the NKG2D ligand MHC class I-related chain A in hepatocellular carcinoma and its therapeutic implication

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Mechanisms for hepatitis B virus replication and mutagenesis : investigations using virus-expressing mouse system.

    • Principal Investigator
      OHKAWA Kazuyoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Analysis of activation of dendritic cells by γ-PGA nano-particle and liver cancer immunotherapyPrincipal Investigator

    • Principal Investigator
      TATSUMI Tomohide
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  非アルコール性脂肪性肝疾患と肝硬変におけるオートファジーの解析とその意義の解明

    • Principal Investigator
      竹原 徹郎
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Molecular regulation of NK cell cytotoxicity fir human hepatocellular carcinoma

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  HBV遺伝子導入マウスでの酵素阻害剤誘発変異の解析とテーラーメイド医療への応用

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Molecular analysis of dendritic cell based vaccines against liver cancerPrincipal Investigator

    • Principal Investigator
      TATSUMI Tomohide
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  CTL immuno-monitoring in chronic hepatitis C

    • Principal Investigator
      HIRAMATSU Naoki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Natural killer receptor-mediated regulation of dendritic cell functions in chronic hepatitis C

    • Principal Investigator
      TAKEHARA Tetsuo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 消化器疾患治療マニュアル第2版「肝硬変」2013

    • Author(s)
      巽 智秀、青野悟志
    • Total Pages
      15
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Book] 肝炎診療マニュアル 「肝癌」2013

    • Author(s)
      巽 智秀
    • Total Pages
      31
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Book] Annual Review 消化器 20122012

    • Author(s)
      巽 智秀、竹原徹郎
    • Total Pages
      5
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Journal Article] Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study2024

    • Author(s)
      Kai M, Hikita H, Kazuki M, Tahata Y, Shinkai K, Doi A, Ohkawa K, Miyazaki M, Ishida H, Matsumoto K, Nozaki Y, Yakushijin T, Sakamori R, Kaneko A, Iio S, Nawa T, Kakita N, Morishita N, Hiramatsu N, Usui T, Imanaka K, Doi Y, Sakakibara M, Yoshida Y, Oze T, Kodama T, Tatsumi T, Takehara T.
    • Journal Title

      PLOS ONE

      Volume: 19 Issue: 1 Pages: e0294590-e0294590

    • DOI

      10.1371/journal.pone.0294590

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15068, KAKENHI-PROJECT-21K07894
  • [Journal Article] STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression2023

    • Author(s)
      Makino Yuki、Hikita Hayato、Kato Seiya、Sugiyama Masaya、Shigekawa Minoru、Sakamoto Tatsuya、Sasaki Yoichi、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kobayashi Shogo、Eguchi Hidetoshi、Takemura Nobuyuki、Kokudo Norihiro、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 15 Issue: 1 Pages: 99-119

    • DOI

      10.1016/j.jcmgh.2022.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-20K08633
  • [Journal Article] The impact of the COVID‐19 pandemic on hepatocellular carcinoma diagnosis and treatment in Japan: A multicenter collaborative observational study2023

    • Author(s)
      Murai Kazuhiro、Hikita Hayato、Kodama Takahiro、Kaibori Masaki、Nishimura Yuki、Tatsumi Tomohide、Yamada Tomomi、Kanto Tatsuya、Mochida Satoshi、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: in press Issue: 5 Pages: 439-450

    • DOI

      10.1111/hepr.13990

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Circulating Cell-Free DNA Profiling Predicts the Therapeutic Outcome in Advanced Hepatocellular Carcinoma Patients Treated with Combination Immunotherapy2022

    • Author(s)
      Matsumae Takayuki、Kodama Takahiro、Myojin Yuta、Maesaka Kazuki、Nakabori Tasuku、Ohkawa Kazuyoshi、Miyazaki Masanori、Tanaka Satoshi、Mita Eiji、Tawara Seiichi、Yakushijin Takayuki、Nozaki Yasutoshi、Hagiwara Hideki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 14 Pages: 3367-3367

    • DOI

      10.3390/cancers14143367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-20H03661
  • [Journal Article] Interleukin-6 Is a Circulating Prognostic Biomarker for Hepatocellular Carcinoma Patients Treated with Combined Immunotherapy2022

    • Author(s)
      Myojin Yuta、Kodama Takahiro、Sakamori Ryotaro、Maesaka Kazuki、Matsumae Takayuki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 4 Pages: 883-883

    • DOI

      10.3390/cancers14040883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21K07894
  • [Journal Article] Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis2022

    • Author(s)
      Tahata Y, Hikita H, Mochida S, Enomoto N, Kawada N, Kurosaki M, Ido A, Miki D, Yoshiji H, Takikawa Y, Sakamori R, Hiasa Y, Nakao K, Kato N, Ueno Y, Yatsuhashi H, Itoh Y, Tateishi R, Suda G, Takami T, Nakamoto Y, Asahina Y, et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 57 Issue: 2 Pages: 120-132

    • DOI

      10.1007/s00535-021-01845-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08458, KAKENHI-PROJECT-21K07909, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
  • [Journal Article] Prediction Model for Intrahepatic Distant Recurrence After Radiofrequency Ablation for Primary Hepatocellular Carcinoma 2cm or Smaller2022

    • Author(s)
      Takigawa Atsuo、Sakamori Ryotaro、Tahata Yuki、Yoshioka Teppei、Yamada Ryoko、Kodama Takahiro、Hikita Hayato、Yakushijin Takayuki、Ohkawa Kazuyoshi、Hiramatsu Naoki、Mita Eiji、Hagiwara Hideki、Ito Toshifmi、Imai Yasuharu、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Digestive Diseases and Sciences

      Volume: in press Issue: 12 Pages: 5704-5711

    • DOI

      10.1007/s10620-022-07455-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] The absence of warfarin treatment and situs inversus are associated with the occurrence of hepatocellular carcinoma after Fontan surgery2022

    • Author(s)
      Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Yamada Tomomi、Takehara Tetsuo
    • Journal Title

      Journal of Gastroenterology

      Volume: 57 Issue: 2 Pages: 111-119

    • DOI

      10.1007/s00535-021-01842-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis2022

    • Author(s)
      Makino Yuki、Hikita Hayato、Fukumoto Kenji、Sung Ji Hyun、Sakano Yoshihiro、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kondo Jumpei、Kobayashi Shogo、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 82 Issue: 16 Pages: 2860-2873

    • DOI

      10.1158/0008-5472.can-21-4390

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21H02903
  • [Journal Article] Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma2022

    • Author(s)
      Murai Hiroki、Kodama Takahiro、Maesaka Kazuki、Tanaka Satoshi、Mita Eiji、Ohkawa Kazuyoshi、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Eguchi Hidetoshi、Morii Eiichi、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: 77 Issue: 1 Pages: 77-91

    • DOI

      10.1002/hep.32573

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K07426, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice2021

    • Author(s)
      Sakane Sadatsugu、Hikita Hayato、Shirai Kumiko、Myojin Yuta、Sasaki Youichi、Kudo Shinnosuke、Fukumoto Kenji、Mizutani Naoki、Tahata Yuki、Makino Yuki、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 12 Issue: 5 Pages: 1683-1699

    • DOI

      10.1016/j.jcmgh.2021.07.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307
  • [Journal Article] Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct‐acting anti‐virals2021

    • Author(s)
      Tahata Yuki、Sakamori Ryotaro、Yamada Ryoko、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo、the Osaka Liver Forum
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 54 Issue: 10 Pages: 1340-1349

    • DOI

      10.1111/apt.16632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-20K16956
  • [Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis2021

    • Author(s)
      Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: in press Issue: 6 Pages: G958-G968

    • DOI

      10.1152/ajpgi.00370.2020

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
  • [Journal Article] Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination2021

    • Author(s)
      Myojin Yuta、Hikita Hayato、Tahata Yuki、Doi Akira、、Kodama Takahiro、Hagiwara Hideki、Imai Yasuharu、Hiramatsu Naoki、Tamura Shinji、Yamamoto Keiji、Ohkawa Kazuyoshi、Hijioka Taizo、Fukui Hiroyuki、Doi Yoshinori、Yamada Yukinori、Yakushijin Takayuki、Mita Eiji、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 55 Issue: 4 Pages: 422-433

    • DOI

      10.1111/apt.16691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production2021

    • Author(s)
      Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T.
    • Journal Title

      Gastroenterology .

      Volume: 160 Issue: 5 Pages: 1741-1754

    • DOI

      10.1053/j.gastro.2020.12.015

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K17489
  • [Journal Article] Efficacy of Ramucirumab <i>Versus</i> Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma2021

    • Author(s)
      MAESAKA KAZUKI、SAKAMORI RYOTARO、YAMADA RYOKO、TAHATA YUKI、OHKAWA KAZUYOSHI、OSHITA MASAHIDE、TAMURA SHINJI、HAGIWARA HIDEKI、MITA EIJI、YAKUSHIJIN TAKAYUKI、INADA MASAMI、KODAMA TAKAHIRO、HIKITA HAYATO、TATSUMI TOMOHIDE、TAKEHARA TETSUO
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 4 Pages: 2187-2192

    • DOI

      10.21873/anticanres.14993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Hyperprogressive disease in patients with unresectable hepatocellular carcinoma receiving atezolizumab plus bevacizumab therapy2021

    • Author(s)
      Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Imai Yasuharu、Ohkawa Kazuyoshi、Miyazaki Masanori、Mita Eiji、Ito Toshifumi、Hagiwara Hideki、Yakushijin Takayuki、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 52 Issue: 3 Pages: 298-307

    • DOI

      10.1111/hepr.13741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration2021

    • Author(s)
      Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 3363-3363

    • DOI

      10.1038/s41598-021-83082-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
  • [Journal Article] Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway2020

    • Author(s)
      Murai Kazuhiro、Hikita Hayato、Kai Yugo、Kondo Yasuteru、Fukuoka Makoto、Fukutomi Keisuke、Doi Akira、Yamai Takuo、Nakabori Tasuku、Fukuda Ryo、Takahashi Takeshi、Miyakawa Kei、Suemizu Hiroshi、Ryo Akihide、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 941-941

    • DOI

      10.1038/s41598-020-57603-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08374, KAKENHI-PROJECT-17K09424, KAKENHI-PROJECT-18H02368
  • [Journal Article] Hepatocellular carcinoma occurrence does not differ between interferon‐based and interferon‐free treatment with liver histological assessment2020

    • Author(s)
      Tahata Yuki、Sakamori Ryotaro、Urabe Ayako、Yamada Ryoko、Ohkawa Kazuyoshi、Hiramatsu Naoki、Hagiwara Hideki、Oshita Masahide、Hijioka Taizo、Tamura Shinji、Imai Yasuharu、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 3 Pages: 313-320

    • DOI

      10.1111/hepr.13454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice2020

    • Author(s)
      Kurahashi Tomohide、Yoshida Yuichi、Ogura Satoshi、Egawa Mayumi、Furuta Kunimaro、Hikita Hayato、Kodama Takahiro、Sakamori Ryotaro、Kiso Shinichi、Kamada Yoshihiro、Wang I-Ching、Eguchi Hidetoshi、Morii Eiichi、Doki Yuichiro、Mori Masaki、Kalinichenko Vladimir V.、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 9 Issue: 3 Pages: 425-446

    • DOI

      10.1016/j.jcmgh.2019.10.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
  • [Journal Article] Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients2019

    • Author(s)
      Kegasawa Tadashi、Tatsumi Tomohide、Yoshioka Teppei、Suda Takahiro、Ikezawa Kenji、Nakabori Tasuku、Yamada Ryoko、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takehara Tetsuo
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 517 Issue: 1 Pages: 84-88

    • DOI

      10.1016/j.bbrc.2019.07.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09424
  • [Journal Article] Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma2019

    • Author(s)
      Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Urabe Ayako、Shigekawa Minoru、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 3 Pages: 365-373

    • DOI

      10.1111/hepr.13446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma2019

    • Author(s)
      Suemura Shigeki、Kodama Takahiro、Myojin Yuta、Yamada Ryoko、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 11 Issue: 9 Pages: 1362-1362

    • DOI

      10.3390/cancers11091362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
  • [Journal Article] DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway2018

    • Author(s)
      Saito Yoshinobu、Hikita Hayato、Nozaki Yasutoshi、Kai Yugo、Makino Yuki、Nakabori Tasuku、Tanaka Satoshi、Yamada Ryoko、Shigekawa Minoru、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cell Death & Differentiation

      Volume: 26 Issue: 3 Pages: 470-486

    • DOI

      10.1038/s41418-018-0131-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422, KAKENHI-PUBLICLY-17H05508, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09423
  • [Journal Article] CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C2018

    • Author(s)
      Suda Takahiro、Tatsumi Tomohide、Nishio Akira、Kegasawa Tadashi、Yoshioka Teppei、Yamada Ryoko、Furuta Kunimaro、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Fukuhara Takasuke、Matsuura Yoshiharu、Takehara Tetsuo
    • Journal Title

      Hepatology Communications

      Volume: 2 Issue: 10 Pages: 1247-1258

    • DOI

      10.1002/hep4.1240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice2018

    • Author(s)
      Aono Satoshi、Tatsumi Tomohide、Yoshioka Teppei、Tawara Seiichi、Nishio Akira、Onishi Yoshiki、Fukutomi Keisuke、Nakabori Tasuku、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takahashi Takeshi、Suemizu Hiroshi、Takehara Tetsuo
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 3 Pages: 1457-1464

    • DOI

      10.1016/j.bbrc.2018.07.063

    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] CTGF Mediates Tumor?Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression2018

    • Author(s)
      Makino Yuki、Hikita Hayato、Kodama Takahiro、Shigekawa Minoru、Yamada Ryoko、Sakamori Ryotaro、Eguchi Hidetoshi、Morii Eiichi、Yokoi Hideki、Mukoyama Masashi、Hiroshi Suemizu、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 17 Pages: 4902-4914

    • DOI

      10.1158/0008-5472.can-17-3844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K15943
  • [Journal Article] Impact of NK cells on chronic hepatitis C and hepatocellular carcinoma2016

    • Author(s)
      Tatsumi T, Takehara T
    • Journal Title

      Hepatol Res

      Volume: In press Issue: 5 Pages: 416-422

    • DOI

      10.1111/hepr.12619

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Journal Article] Evaluation of Fucosylated Haptoglobin and Mac-2 Binding Protein as Serum Biomarkers to Estimate Liver Fibrosis in Patients with Chronic Hepatitis C.2016

    • Author(s)
      Tawara S, Tatsumi T, Iio S, Kobayashi I, Shigekawa M, Hikita H, Sakamori R, Hiramatsu N, Miyoshi E, Takehara T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0151828-e0151828

    • DOI

      10.1371/journal.pone.0151828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Journal Article] Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.2016

    • Author(s)
      Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T.
    • Journal Title

      Hepatology

      Volume: 64 Issue: 6 Pages: 1994-2014

    • DOI

      10.1002/hep.28820

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01204, KAKENHI-PROJECT-26253047, KAKENHI-PROJECT-15H04371
  • [Journal Article] The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon plus ribavirin in Japanese patients with HCV genotype 1.2015

    • Author(s)
      Oze T, Hiramatsu N, Yoshida Y et al.
    • Journal Title

      J Gastroenterol.

      Volume: 50 Issue: 3 Pages: 313-322

    • DOI

      10.1007/s00535-014-0965-8

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590975, KAKENHI-PROJECT-25460993, KAKENHI-PROJECT-26461001, KAKENHI-PROJECT-26860503
  • [Journal Article] Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.2015

    • Author(s)
      Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T.
    • Journal Title

      J Gastroenterol.

      Volume: 50(11) Issue: 11 Pages: 1145-1151

    • DOI

      10.1007/s00535-015-1108-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461002, KAKENHI-PROJECT-26860503
  • [Journal Article] Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.2015

    • Author(s)
      Nishio K, Miyagi T, Tatsumi T, Mukai K, Yokoyama Y, Yoshioka T, Sakamori R, Hikita H, Kodama T, Shimizu S, Shigekawa M, Nawa T, Yoshihara H, Hiramatsu N, Yamanaka H, Seino K, Takehara T.
    • Journal Title

      J Gastroenterol.

      Volume: 50(11) Issue: 11 Pages: 1124-1133

    • DOI

      10.1007/s00535-015-1060-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461002
  • [Journal Article] The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.2015

    • Author(s)
      Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.
    • Journal Title

      PLoS One.

      Volume: 10(12) Issue: 12 Pages: e0144775-e0144775

    • DOI

      10.1371/journal.pone.0144775

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461002, KAKENHI-PROJECT-26290034
  • [Journal Article] Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver Tumorigenesis.2015

    • Author(s)
      Hikita H, Kodama T, Tanaka S, Saito Y, Nozaki Y, Nakabori T, Shimizu S, Hayashi Y, Li W, Shigekawa M, Sakamori R, Miyagi T, Hiramatsu N, Tatsumi T, Takehara T.
    • Journal Title

      Cancer Prev Res (Phila).

      Volume: 8(8) Issue: 8 Pages: 693-701

    • DOI

      10.1158/1940-6207.capr-15-0022-t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461002
  • [Journal Article] Risk factors for hepatocellular carcinoma in hepatitis C patients with normal ALT treated with pegylated interferon and ribavirin2014

    • Author(s)
      Harada N, Hiramatsu N, Oze T, Morishita N, Yamada R, Hikita H, Miyazaki M, Yakushijin T, Miyagi T, Yoshida Y, Tatsumi T, Kanto A, Kasahara A, Oshita M, Mita E, Hagiwara H, Inui Y, Katayama K, Shinji Tamura, Yoshihara H, Imai Y, Inoue A, Hayashi N, Takehara T
    • Journal Title

      J Viral Hepat

      Volume: 21 Issue: 5 Pages: 357-365

    • DOI

      10.1111/jvh.12151

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24590975, KAKENHI-PROJECT-25460994, KAKENHI-PROJECT-26860503
  • [Journal Article] The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice2013

    • Author(s)
      Aketa H, Tatsumi T, Kohga K, Tsunematsu H, Aono S, Shimizu S, Kodama T, Nawa T, Shigekawa M, Hikita H, Sakamori R, Hosui A, Miyagi T, Hiramatsu N, Kanto T, Hayashi N, Takehara T
    • Journal Title

      Int J Cancer

      Volume: 133 Issue: 5 Pages: 1126-34

    • DOI

      10.1002/ijc.28118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
  • [Journal Article] Incidence of hepatocellular carcinoma in HCV-infected patients with normal alanine aminotransferase levels categorized by Japanese treatment guidelines2013

    • Author(s)
      Harada N, Hiramatsu N, Oze T, Yamada R, Kurokawa M, Miyazaki M, Yakushijin T, Miyagi T, Tatsumi T, Kiso S, Kanto T, Kasahara A, Oshita M, Mita E, Hagiwara H, Inui Y, Katayama K, Tamura S, Yoshihara H, Imai Y, Inoue A, Hayashi N, Takehara T
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 4 Pages: 535-43

    • DOI

      10.1007/s00535-012-0657-1

    • NAID

      10031169228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver.2013

    • Author(s)
      [1] Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 42 Pages: 30009-30018

    • DOI

      10.1074/jbc.m112.443093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
  • [Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver2013

    • Author(s)
      Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T
    • Journal Title

      J. Biol. Chem

      Volume: 288 Pages: 30009-30018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Journal Article] the Osaka Liver Forum. Post-treatment Levels ofα-fetoprotein Predict Incidence of Hepatocellular Carcinoma After Interferon Therapy2013

    • Author(s)
      Oze T, Yoshida Y,他25人
    • Journal Title

      Clin Gastroenterol Hepatol

      Volume: (Epub ahead of print), (pii : S1542-3565(13)01840-5) Issue: 7 Pages: 1239-45

    • DOI

      10.1016/j.cgh.2013.11.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-25460994, KAKENHI-PROJECT-26461001, KAKENHI-PROJECT-26860503
  • [Journal Article] Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation2013

    • Author(s)
      Ishida H, Kato T, Takehana K, Tatsumi T, Hosui A, Nawa T, Kodama T, Shimizu S, Hikita H, Hiramatsu N, Kanto T, Hayashi N, Takehara T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Issue: 1 Pages: 127-33

    • DOI

      10.1016/j.bbrc.2013.06.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
  • [Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2012

    • Author(s)
      Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
    • Journal Title

      Int J Cancer

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Suppression of signal transducers and activators of transcription 1 (STAT1) in hepatocellular carcinoma is associated with tumor progression2012

    • Author(s)
      Hosui A, Tatsumi T, et al.
    • Journal Title

      International Journal of Cancer

      Volume: 131 Issue: 12 Pages: 2774-2784

    • DOI

      10.1002/ijc.27580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Journal Article] Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells2012

    • Author(s)
      Tsunematsu H, Tatsumi T, et al
    • Journal Title

      International Journal of Cancer

      Volume: 130 Issue: 2 Pages: 356-364

    • DOI

      10.1002/ijc.26003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Bak deficiency inhibits liver carcinogenesis : A causal link between apoptosis and carcinogenesis2012

    • Author(s)
      Hikita H, Takehara T, et al
    • Journal Title

      Journal of Hepatology

      Volume: (印刷中) Issue: 1 Pages: 92-100

    • DOI

      10.1016/j.jhep.2012.01.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188, KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694
  • [Journal Article] Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma2012

    • Author(s)
      Kohga K, Tatsumi T, et al.
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 61 Pages: 1425-1432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Journal Article] Bak deficiency inhibits liver carcinogenesis : a causal link between apoptosis and carcinogenesis2012

    • Author(s)
      Hikita H, Kodama T, Shimizu S, Li W, Shigekawa M, Tanaka S, Hosui A, Miyagi T, Tatsumi T, Kanto T, Hiramatsu N, Morii E, Hayashi N, Takehara T
    • Journal Title

      J Hepatol

      Volume: 57 Pages: 92-100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Journal Article] Bak deficiency inhibits liver carcinogenesis : A causal link between apoptosis and carcinogenesi2012

    • Author(s)
      Hikita H, Kodama T, Shimizu S, Li W, Shigekawa M, Tanaka S, Hosui A, Miyagi T, Tatsumi T, Kanto T, Hiramatsu N, Morii E, Hayashi N, Takehara T
    • Journal Title

      J Hepatol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.2012

    • Author(s)
      Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
    • Journal Title

      Cell Death Differ.

      Volume: 19(11) Issue: 11 Pages: 1856-1869

    • DOI

      10.1038/cdd.2012.88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24591422, KAKENHI-PROJECT-24790694
  • [Journal Article] Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway2012

    • Author(s)
      Nawa T, Tatsumi T, et al.
    • Journal Title

      Virology

      Volume: 432 Issue: 2 Pages: 452-459

    • DOI

      10.1016/j.virol.2012.07.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694
  • [Journal Article] Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells2012

    • Author(s)
      Tsunematsu H, Tatsumi T(2番目), Takehara T(11番目)(他8名)
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 356-364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Inhibition of autophagy potentiates the anti-tumor effect of the multi-kinase inhibitor sorafenib in hepatocellular carcinoma2012

    • Author(s)
      Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
    • Journal Title

      Int J Cancer

      Volume: 131 Pages: 548-557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Journal Article] Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction2012

    • Author(s)
      Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T.
    • Journal Title

      Am J Pathol

      Volume: 101 Pages: 2105-2113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659364
  • [Journal Article] Pancreatitis STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction2012

    • Author(s)
      Shigekawa M, Tatsumi T, et al.
    • Journal Title

      The American Journal of Pathology

      Volume: 181 Issue: 6 Pages: 2105-2113

    • DOI

      10.1016/j.ajpath.2012.08.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24659364, KAKENHI-PROJECT-24790694
  • [Journal Article] α-galactosylceramide activates antitumor immunity against liver tumor2011

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目)(他7名)
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 160-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin2011

    • Author(s)
      Inoue Y, Tatsumi T(14番目), Takehara T(18番目)(他16名)
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 419-427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Hepatitis C virus-specific CD8+ T cell frequencies are associated with the responses of pegylated interferon-αand ribavirin combination therapy in patients with chronic hepatitis C virus infection2011

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目)(他8名)
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 30-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice2011

    • Author(s)
      Shigekawa M, Tatsumi T, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 406 Pages: 614-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice2011

    • Author(s)
      Kodama T, Tatsumi T, et al
    • Journal Title

      The Journal of Clinical Investigation

      Volume: 121 Pages: 2243-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice2011

    • Author(s)
      Shigekawa M, Takehara T(2番目), Tatsumi T(9番目)(他10名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 614-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Alternations in microRNA expression profile in HCV-infected hepatoma cells : Involvement of miR-491 in regulation of HCV replication via PI3 kinase/ Akt pathway2011

    • Author(s)
      Ishida H, Tatsumi T(2番目), Takehara T(11番目)(他8名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Pages: 92-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/ Bax-deficient mice2011

    • Author(s)
      Hikita H, Takehara T, Kodama T, Shimizu S, Shigekawa M, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Shimizu S, Tsujimoto Y, Hayashi N
    • Journal Title

      Hepatology

      Volume: 54 Pages: 240-251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fasactivation in Bak/Bax-deficient mice2011

    • Author(s)
      Hikita, H.
    • Journal Title

      Hepatology

      Volume: VOL. 54 Issue: 1 Pages: 240-251

    • DOI

      10.1002/hep.24305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0316, KAKENHI-PROJECT-21590841, KAKENHI-PROJECT-21659188, KAKENHI-PUBLICLY-22020009, KAKENHI-PUBLICLY-22121505, KAKENHI-PROJECT-22229002, KAKENHI-PROJECT-23657084
  • [Journal Article] BH3-only activator proteins, Bid and Bim, are dispensable for Bak/ Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency : Molecular requisites for the mitochondrial pathway to apoptosis in platelets2011

    • Author(s)
      Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 13905-13913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Hepatitis C virus (HCV)-specific CD8+ T cell responses during pegylated interferon-alfa and ribavirin treatment are associated with the antiviral activity in patients with chronic hepatitis C virus infection.2011

    • Author(s)
      Tatsumi T, Takehara T, Miyagi T, Nakazuru S, Mita E, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      Hepatol Res 41

      Pages: 30-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] α-galactosylceramide activates antitumor immunity against liver tumor2011

    • Author(s)
      Tatsumi T, et al
    • Journal Title

      Hepatology Research

      Volume: 41 Issue: 2 Pages: 160-169

    • DOI

      10.1111/j.1872-034x.2010.00743.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin2011

    • Author(s)
      Inoue Y, Tatsumi T, et al
    • Journal Title

      Journal of Medical Virology

      Volume: 83 Issue: 3 Pages: 419-427

    • DOI

      10.1002/jmv.21975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841, KAKENHI-PROJECT-22590730, KAKENHI-PROJECT-23590974
  • [Journal Article] Hepatitis C virus-specific CD8+ T cell frequencies are associated with the responses of pegylated interferon-α and ribavirin combination therapy in patients with chronic hepatitis C virus infection2011

    • Author(s)
      Tatsumi T, et al
    • Journal Title

      Hepatology Research

      Volume: 41 Issue: 1 Pages: 30-38

    • DOI

      10.1111/j.1872-034x.2010.00734.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice2011

    • Author(s)
      Kodama T, Takehara T(2番目), Tatsumi T(10番目)(他18名)
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3343-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] ・-galactosylceramide activates antitumor immunity against liver tumor.2011

    • Author(s)
      Tatsumi T, Takehara T, Miyagi T, Sugiyama T, Aketa H, Sasakawa A, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      Hepatol Res 41

      Pages: 30-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] BH3-only activator proteins Bid and Bim are dispensable for Bak/ Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency2011

    • Author(s)
      Kodama T, Takehara T(2番目), Tatsumi T(9番目)(他10名)
    • Journal Title

      J Bio Chem

      Volume: 286(16) Pages: 13905-13913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Efficacy of re-treatment with pegylated interferon plus ribavirin combination therpy for patients with chronic hepatitis C in Japan2011

    • Author(s)
      Oze T, Tatsumi T, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 8 Pages: 1031-1037

    • DOI

      10.1007/s00535-011-0409-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841, KAKENHI-PROJECT-23590974
  • [Journal Article] Alternations in microRNA expression profile in HCV-infected hepatoma cells : Involvement of miR-491 in regulation of HCV replication via PI3 kinase/Akt pathway2011

    • Author(s)
      Ishida H, Tatsumi T, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 412 Pages: 92-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] α-fetoprotein impairs activation of NK cells by inhibiting the function of dendritic cells2011

    • Author(s)
      Yamamoto M, Tatsumi T, et al
    • Journal Title

      Clinical and Experimental Immunology

      Volume: 165 Issue: 2 Pages: 211-219

    • DOI

      10.1111/j.1365-2249.2011.04421.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] α-fetoprotein impairs activation of NK cells by inhibiting the function of dendritic cells2011

    • Author(s)
      Yamamoto M, Tatsumi T(2番目), Takehara T(10番目)(他7名)
    • Journal Title

      Clin Exp Immunol

      Volume: 165 Pages: 211-219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice2011

    • Author(s)
      Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3343-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy2011

    • Author(s)
      Oze T, Tatsumi T, et al
    • Journal Title

      Journal of Hepatology

      Volume: 121 Pages: 3343-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/ Bax-deficient mice2011

    • Author(s)
      Hikita H, Takehara T(2番目), Tatsumi T(8番目)(他12名)
    • Journal Title

      Hepatology

      Pages: 240-251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency2011

    • Author(s)
      Kodama T, Tatsumi T, et al
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 13905-13913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Differential alteration of CD56^<bright> and CD56^<dim> natural killer cells in frequency, phenotype and cytokine response in chronic hepatitis C virus infection2011

    • Author(s)
      Miyagi T, Tatsumi T, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 8 Pages: 1020-1030

    • DOI

      10.1007/s00535-011-0408-8

    • NAID

      10029563284

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841, KAKENHI-PROJECT-21590842
  • [Journal Article] Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma2010

    • Author(s)
      Kohga K, Tatsumi T(2番目), Takehara T(3番目)(他6名)
    • Journal Title

      J Hepatol

      Volume: 52 Pages: 872-879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection2010

    • Author(s)
      Miyagi T, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology

      Volume: 53 Pages: 424-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] The let7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma2010

    • Author(s)
      Shimizu S, Takehara T(2番目), Tatsumi T(7番目)(他10名)
    • Journal Title

      J Hepatol

      Volume: 52 Pages: 698-704

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Natural Killer cell is a major producer of interferon γ that is critical for the IL-12-induced antitumor effect in mice2010

    • Author(s)
      Uemura A, Tatsumi T, et al.
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 59 Pages: 453-463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Fatal exacerbation of type B chronic hepatitis trigged by changes in relaxed circular viral DNA synthesis and virion secretion2010

    • Author(s)
      Ohkawa K, Tatsumi T, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 394 Pages: 87-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] STAT3 signaling within hepatocyte is required for anemia of inflammation in vivo2010

    • Author(s)
      Sakamori R, Takehara T(2番目), Tatsumi T(3番目)(他5名)
    • Journal Title

      J Gastroenterology

      Volume: 45 Pages: 244-248

    • NAID

      10027214771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Fatal exacerbation of type B chronic hepatitis trigged by changes in relaxed circular viral DNA synthesis and virion secretion2010

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(14番目)(他13名)
    • Journal Title

      Biochemi Biophys Res Commun

      Volume: 394 Pages: 87-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice2010

    • Author(s)
      Kodama T, Takehara T(2番目), Tatsumi T(8番目)(他11名)
    • Journal Title

      Gastroenterology

      Volume: 138 Pages: 2487-2498

    • NAID

      40017376760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Natural killer cell is a major producer of interferon・that is critical for the IL-12-induced anti-tumor effect in mice.2010

    • Author(s)
      Uemura A, Takehara T, Miyagi T, Suzuki T, Tatsumi T, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      Cancer Immunol Immunother 59

      Pages: 453-463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib2010

    • Author(s)
      Hikita H, Takehara T(2番目), Tatsumi T(9番目)(他11名)
    • Journal Title

      Hepatology

      Volume: 52 Pages: 1310-1321

    • NAID

      40018998703

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet2010

    • Author(s)
      Miyagi T, Tatsumi T, et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 45 Pages: 1247-1254

    • NAID

      10027700169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma2010

    • Author(s)
      Kohga K, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology

      Volume: 52 Pages: 872-879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] The Bcl-xL inhibitor, ABTT-737, efficiently induced apoptosis suppresses growth of hepatoma cells in combination with sorafenib2010

    • Author(s)
      Hikita H, Tatsumi T, et al.
    • Journal Title

      Hepatology

      Volume: 52 Pages: 1310-1321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Sorafenib inhibited the shedding of MICA on hepatocellular carcinoma cells by downregulating ADAM9.2010

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, Ishida H, Miyagi T, Hosui A, Hayashi N.
    • Journal Title

      Hepatology 51

      Pages: 1264-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] STAT3 signaling within hepatocyte is required for anemia of inflammation in vivo2010

    • Author(s)
      Sakamori R, Tatsumi T, et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 45 Pages: 244-248

    • NAID

      10027214771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Altered interferon-alpha-signaling in NK cells from the patients with chronic hepatitis C virus infection.2010

    • Author(s)
      Miyagi T, Takehara T, Nishio K, Shimizu S, Kohga K, Tatsumi T, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      J Hepatol 53

      Pages: 424-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet.2010

    • Author(s)
      Miyagi T, Takehara T, Uemura A, Nishio K, Shimizu S, Kodama T, Hikita H, Li W, Sasakawa A, Tatsumi T, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      J Gastroenterol 45

      Pages: 1247-1254

    • NAID

      10027700169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Expression of CD133 confers malignant potential via inhibiting metalloproteinases in human hepatocellular carcinoma.2010

    • Author(s)
      Kohga K, Tatsumi T, Takehara T, Miyagi T, Hayashi N.
    • Journal Title

      J Hepatol 52

      Pages: 872-879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection2010

    • Author(s)
      Miyagi T, Takehara T(2番目), Tatsumi T(7番目)(他7名)
    • Journal Title

      J Hepatol

      Volume: 53 Pages: 424-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib2010

    • Author(s)
      Hikita H, Takehara T, Shimizu S, Kodama T, Shigekawa M, Iwase K, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Hayashi N
    • Journal Title

      Hepatology

      Volume: 52 Pages: 1310-1321

    • NAID

      40018998703

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Alterations in hepatitis B virus nucleotide sequences in a chronic virus carrier from immunotolerant to immunoactive phase2010

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(3番目), (他8名)
    • Journal Title

      Biochemi Biophys Res Commun

      Volume: 394 Pages: 574-580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Sorafenib inhibits the shedding of MICA on hepatocellular cacrcinoma cell by downregulating ADAM92010

    • Author(s)
      Kohga K, Tatsumi T, et al.
    • Journal Title

      Hepatology

      Volume: 51 Pages: 1264-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor2010

    • Author(s)
      Yamaguchi, Tatsumi T, et al.
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 59 Pages: 759-767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] EphA2-derived peptide vaccine with amphiphilic poly (γ-glutamic acid) nanoparticles elicits an antitumor effect against mouse liver tumor.2010

    • Author(s)
      Yamaguchi S, Tatsumi T, Takehara T, Sasakawa A, Yamamoto M, Kohga K, Miyagi T, Kanto T, Hiramatsu N, Akagi T, Akashi M, Hayashi N.
    • Journal Title

      Cancer Immunol Immunother 59

      Pages: 759-767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor2010

    • Author(s)
      Yamaguchi S, Tatsumi T(2番目), Takehara T(3番目)(他9名)
    • Journal Title

      EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor

      Volume: 59 Pages: 759-767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Sorafenib inhibits the shedding of major histocomaptibility complex class I-related chain A on hepatocellular cacrcinoma cells by down-regulating a disintegrin and metalloproteinase 92010

    • Author(s)
      Kohga K, Takehara T(2番目), Tatsumi T(3番目)(他4名)
    • Journal Title

      Hepatology

      Volume: 51 Pages: 1264-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice2010

    • Author(s)
      Kodama T, Takehara T, Hikita H, Shimizu S, Wei Li, Miyagi T, Hosui A, Tatsumi T, Ishida H, Tadokoro S, Ido A, Tsubouchi H, Hayashi N
    • Journal Title

      Gastroenterology

      Volume: 138 Pages: 2487-2498

    • NAID

      40017376760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet2010

    • Author(s)
      Miyagi T, Takehara T(2番目), Tatsumi T(10番目)(他11名)
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 1247-1254

    • NAID

      10027700169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] The let7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma2010

    • Author(s)
      Shimizu S, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology

      Volume: 52 Pages: 698-704

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells2009

    • Author(s)
      Hikita H, Tatsumi T, et al
    • Journal Title

      Hepatology 50

      Pages: 1972-1980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells2009

    • Author(s)
      Hikita H, Takehara T(2番目), Tatsumi T(7番目)(他12名)
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1972-1980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Mutations associated with therapeutic efficacy of Adefovir dipivoxil added to Lamivudine in patients resistant to Lamivudine with type B chronic hepatitis2009

    • Author(s)
      Ohkawa K, Tatsumi T, et al
    • Journal Title

      Journal of Medical Virology 81

      Pages: 798-806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Activated liver dendritic cells generates strong acquired immunity inα-galactosylceramide treatment2009

    • Author(s)
      Sasakawa A, Tatsumi T(2番目), Takehara T(3番目)(他6名)
    • Journal Title

      J Hepatol

      Volume: 50 Pages: 1155-1162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells2009

    • Author(s)
      Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1972-1980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Activated liver dendritic cells generates strong acquired immunity in・-galactosylceramide treatment.2009

    • Author(s)
      Sasakawa A, Tatsumi T, Takehara T, Yamaguchi S, Yamamoto M, Ohkawa K, Miyagi T, Hayashi N.
    • Journal Title

      J Hepatol 50

      Pages: 1155-1162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin2009

    • Author(s)
      Hiramatsu N, Tatsumi T, et al
    • Journal Title

      Journal of Viral Hepatitis 16

      Pages: 586-594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Activated liver dendritic cells generates strong acquired immunity in α-galactosylc eramide treatment2009

    • Author(s)
      Sasakawa A, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology 50

      Pages: 1155-1162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult liver2009

    • Author(s)
      Hikita H, Tatsumi T, et al
    • Journal Title

      Hepatology 50

      Pages: 1217-1226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Anti-cancer chemotherapy inhibits MICA ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma2009

    • Author(s)
      Kohga K, Tatsumi T, et al
    • Journal Title

      Camcer Research 69

      Pages: 8050-8057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Pegylated interferon alpha-2b (Peg-IFN alpha-2b) affects early virologic response dose-dependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN alpha-2b plus ribavirin2009

    • Author(s)
      Oze T, Tatsumi T, et al.
    • Journal Title

      Journal of Viral Hepatitis 16

      Pages: 578-585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Anti-cancer therapy inhibits MICA ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.2009

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      Cancer Res 69

      Pages: 8050-8057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver2009

    • Author(s)
      Hikita H, Takehara T, Shimizu S, Kodama T, Li W, Miyagi T, Hosui A, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Yin XM, Hennighausen L, Tatsumi T, Hayashi N
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1217-1226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult liver2009

    • Author(s)
      Hikita H, Takehara T(2番目), Tatsumi T(14番目)(他12名)
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1217-1226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Journal Article] Serum levels of soluble major histocompatibility complex (MHC)class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma2008

    • Author(s)
      Kohga K, Tatsumi T, et al.
    • Journal Title

      Cancer Science 99

      Pages: 1643-1649

    • NAID

      10024010054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Dendritic cell-based vaccines suppress liver tumor via activation of in nate and acquired immunity2008

    • Author(s)
      Yamaguchi S, Tatsumi T, et al.
    • Journal Title

      Cancer Immunology, Immunotherapy 57

      Pages: 1861-8169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity.2008

    • Author(s)
      Yamaguchi S, Tatsumi T, Takehara T, Sasakawa A, Hikita H, Kohga K, Uemura A, Sakamori R, Ohkawa K, Hayashi N.
    • Journal Title

      Cancer Immunol Immunother 57

      Pages: 1861-1869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Early emergence ofentecavir-resistant hepatitis B virusin a patient with hepatitis Bvirus/human immunodeficiency viruscoinfection2008

    • Author(s)
      Kanada A, Takehara T(2番目)Tatsumi T(5番目), (他13名)
    • Journal Title

      Heptol. Res 35

      Pages: 622-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Supportive roleplayed by Precore and PreS2 genomic changes in establishment of Lamivudine-Resitant Hepatitis B virus2008

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(14番名), (他12名)
    • Journal Title

      J. Infect. Dis 198

      Pages: 1150-1158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Activated liver dendritic cells generates strong acquired immunity in a-galactosylceramide treatment2008

    • Author(s)
      Sasakawa A, Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Decreased expressions ofCD1d molecule on liver dendritic cellsin subcutaneous tumor bearing mice2008

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), (他7名)
    • Journal Title

      J. Hepatol 49

      Pages: 779-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection2008

    • Author(s)
      Kanada A, Tatsumi T, et al.
    • Journal Title

      Hepatology Research 38

      Pages: 622-628

    • NAID

      10024149003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Supportive role played by Precore and PreS2 genomic changes in establishment of Lamivudine-Resitant Hepatitis B virus2008

    • Author(s)
      Ohkawa K, Tatsumi T, et al
    • Journal Title

      The Journal of Infectious Diseases 198

      Pages: 1150-1158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Decreased expressions of CDld molecule on liver dendritic cells in subcutaneous tuior bearing mice.2008

    • Author(s)
      Tatsumi T, Takehara T, et al.
    • Journal Title

      J Hepatol 49

      Pages: 779-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Activated liverdendritic cells generates strongacquired immunity inα-galactosylceramide treatment2008

    • Author(s)
      Sasakawa A, Tatsumi T(2番目), Takehara T(3番目), (他5名)
    • Journal Title

      J. Hepatol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Serum levels of soluble MHC class I-related chain A in patients with chronic liver diseases and the changes during transcatheter arterial embolization for hepatocellular carcinoma.2008

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, Ohkawa K, Miyagi T, Hiramatsu N, Kanto T, Kasugai T, Katayama K, Kato M, Hayashi N.
    • Journal Title

      Cancer Sci 99

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Serum levels ofsoluble major histocompatibilitycomplex (MHC) class I-related chain Ain patients with chronic liverdiseases and changes duringtranscatheter arterial embolizationfor hepatocellular carcinoma2008

    • Author(s)
      Kohga K, Takehara T(2番目), TatsumiT(3番目), (他8名)
    • Journal Title

      Cancer Sci 99

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Decreased expressions of CDld molecule on liver dendritic cells in subcutaneous tumor bearing mice.2008

    • Author(s)
      Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Yamamoto M, Fujita Y, Miyagi T, Ohkawa K, Hayashi N.
    • Journal Title

      J Hepatol 49

      Pages: 779-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Mutations associated with therapeutic efficacy of Adefovir dipivoxil added to Lamivudine-resistant chronic hepatitis B2008

    • Author(s)
      Ohkawa K, Tatsumi T, et al.
    • Journal Title

      Journal of Medical Virology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice2008

    • Author(s)
      Tatsumi T, et al.
    • Journal Title

      Journal of Hepatology 49

      Pages: 779-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Mutationsassociated with therapeutic efficacyof Adefovir dipivoxil added toLamivudine-resistant chronichepatitis B2008

    • Author(s)
      Ohkawa K, Takehara T(2番目), Tatsumi T(15番目), (他13名))
    • Journal Title

      J. Med. Virol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Dendritic cell-based vaccines suppress livertumor via activation of innate and acquired immunity2008

    • Author(s)
      Yamaguchi S, Tatsumi T(2番目), Takehara T(3番目), (他7名)
    • Journal Title

      Cancer Immunol. Immunother 57

      Pages: 1861-1869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFN alpha gene to mice2007

    • Author(s)
      Takehara T., Tatsumi T., et al.
    • Journal Title

      International Journal of Cancer 120

      Pages: 1252-1260

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity2007

    • Author(s)
      Tatsumi T., et al.
    • Journal Title

      Gene Therapy (in press)

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity.2007

    • Author(s)
      Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Miyagi T, Jinushi M, Sakamori R, Kouga K, Uemura A, Ohkawa K, Storkus WJ, Hayashi N.
    • Journal Title

      Gene Ther. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Immunotherapy ofmurine colon cancer using receptortyrosine kinase EphA2 derivedpeptide-pulsed dendritic cellvaccines2007

    • Author(s)
      Yamaguchi, Tatsumi T(2番目), Takehara T(3番目), (他7名)
    • Journal Title

      Cancer 110

      Pages: 1469-1477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Intrahepatic delivery of α-galatosylceramide pulsed dendritic cells suppresses liver tumor.2007

    • Author(s)
      Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Sakamori R, Ohkawa K, Kohga K, Uemura A, Hayashi N.
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Intrahepatic delivery of α-galactosylceramide-pulsed dendritic cells suppresses liver tumor.2007

    • Author(s)
      Tatsumi T, Takehara T, et. al.
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • NAID

      40015716465

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Natural Killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4+CD25+ T cells with PD-1-dependent regulatory activities.2007

    • Author(s)
      Jinushi M, Takehara T, Tatsumi T, Yamaguchi S, Sakamori R, Hiramastu N, Kanto T, Ohkawa K, Hayashi N.
    • Journal Title

      Immunology 120

      Pages: 73-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines.2007

    • Author(s)
      Yamaguchi S, Tatsumi T, et. al.
    • Journal Title

      Cancer 110

      Pages: 1469-1477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain2007

    • Author(s)
      Kanada A, Tatsumi T, et. al.
    • Journal Title

      Intervirology 50

      Pages: 394-401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Intrahepatic delivery of α-galactosylceramide-pulsed dendritic cells suppresses liver tumor2007

    • Author(s)
      Tatsumi, T., Takehara, T., Yamaguchi, S., Sasakawa, A., Sakamori, R., Ohkawa, K., Kohga, K., Uemura, A., Hayashi, N
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • NAID

      40015716465

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Natural Killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4+CD25+ T cells with PD-1-dependent regulatory activities2007

    • Author(s)
      Jinushi M., Tatsumi T., et al.
    • Journal Title

      Immunology 120

      Pages: 73-82

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity.2007

    • Author(s)
      Tatsumi T, Takehara T, et. al.
    • Journal Title

      Gene Ther 14

      Pages: 863-871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Natural Killer celland hepatic cell interaction via NKG2Aleads to dendritic cell-mediatedinduction of CD4+CD25+ T cells with PD-1-dependent regulatory activities2007

    • Author(s)
      Jinushi M, Takehara T(2番目), Tatsumi T(3番目), (他6名)
    • Journal Title

      Immunology 120

      Pages: 73-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity2007

    • Author(s)
      Tatsumi T, et. al.
    • Journal Title

      Gene Therapy 14

      Pages: 863-871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Signal Transducer and Activator of Transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice2007

    • Author(s)
      Sakamori R, Tatsumi T, et. al.
    • Journal Title

      Hepatology 46

      Pages: 1564-1573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2 derived peptide-pulsed dendritic cell vaccines2007

    • Author(s)
      Yamaguchi S, Tatsumi T, et. al.
    • Journal Title

      Cancer 110

      Pages: 1469-1477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Intrahepatic delivery ofα-galatosylceramide pulsed dendriticcells suppresses liver tumor2007

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), (他7名)
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Natural killercell-mediated ablation of metastaticliver tumors by hydrodynamic injectionof IFN alpha gene to mice2007

    • Author(s)
      Takehara T(1番目), Tatsumi T(3番目), ( 他8名)
    • Journal Title

      Int. J. Cancer 120

      Pages: 1252-1260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Type B fulminanthepatitis is closely associated witha highly mutated hepatitis B virusstrain2007

    • Author(s)
      Kanada A, Takehara T(2番目), Tatsumi T(4番目), (他14名)
    • Journal Title

      Intervirology 50

      Pages: 294-401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNα gene to mice2007

    • Author(s)
      Takehara, T., Uemura, A., Tatsumi, T., Suzuki, T., Kimura, R., Shiotani, A., Ohkawa, K., Kanto, T., Hiramatsu, N., Hayashi, N
    • Journal Title

      Int J Cancer 120

      Pages: 1252-1260

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Intrahepatic delivery of α-galatosylceramide pulsed dendritic cells suppresses liver tumor2007

    • Author(s)
      Tatsumi T., et al.
    • Journal Title

      Hepatology 45

      Pages: 22-30

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4+ CD25+ T cells with PD-1-dependent regulatory activities2007

    • Author(s)
      Jinushi, M., Takehara, T., Tatsumi, T., Yamaguchi, S., Sakamori, R., Hiramatsu, N., Kanto, T., Ohkawa, K., Hayashi, N
    • Journal Title

      Immunology 120

      Pages: 73-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Journal Article] Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFN alpha gene to mice2007

    • Author(s)
      Takehara T, Uemura A, Tatsumi T, Suzuki T, Kimura R, Shiotani A, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    • Journal Title

      Int.J.Cancer 120

      Pages: 1252-1260

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Signal Transducerand Activator of Transcription 3signaling within hepatocytesattenuates systemic inflammatoryresponse and lethality in septic mice2007

    • Author(s)
      Sakamori R, Takehara T(2番目), Tatsumi T(4番目), (他5名)
    • Journal Title

      Hepatology 46

      Pages: 1564-1573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Injection of IL-12gene-transduced dendritic cells intomouse liver tumor lesions activatesboth innate and acquired immunity2007

    • Author(s)
      Tatsumi T(1番目), Takehara T(2番目), ( 他10名)
    • Journal Title

      Gene Ther 14

      Pages: 863-871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Journal Article] Viral covalently closed circular DNA in a non-transgenic mouse model for chronic hepatitis B virus replication.2006

    • Author(s)
      Takehara T, Suzuki T, Ohkawa K, Housui A, Jinushi M, Miyagi T, Tatsumi T, Kanazawa Y, Hayashi N.
    • Journal Title

      Journal of Hepatology 44

      Pages: 267-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Viral covalently closed circular DNA in a non-transgenic mouse model for chronic hepatitis B virus replication2006

    • Author(s)
      Tekehara T., Tatsumi T., et al.
    • Journal Title

      Journal of Hepatology 44

      Pages: 267-274

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Viral covalently closed circular DNA in a non-transgenic mouse model for chronic hepatitis B virus replication2006

    • Author(s)
      Takehara T., Tatsumi T., et al.
    • Journal Title

      Journal of Hepatology 44

      Pages: 267-274

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Suppressive effect on heptocyte differentiation of hepatitis C virus core protein2006

    • Author(s)
      Hosui A., Tatsumi T., et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 346

      Pages: 1126-1130

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Nitric Oxide sensitizes tumor cells to dendritic cells-mediated apoptosis, uptake and cross-presentation2005

    • Author(s)
      Huang J., Tatsumi T., et al.
    • Journal Title

      Cancer Research 65

      Pages: 8461-8470

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinoma.2005

    • Author(s)
      Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N.
    • Journal Title

      J.Hepatol. 43

      Pages: 1013-1020

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinoma.2005

    • Author(s)
      Jinushi M., Tatsumi T., et al.
    • Journal Title

      Journal of Hepatology 43

      Pages: 1013-1020

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinoma.2005

    • Author(s)
      Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N.
    • Journal Title

      J.Hepatol. 43

      Pages: 1013-1020

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590640
  • [Journal Article] Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas.2005

    • Author(s)
      Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N.
    • Journal Title

      Journal of Hepatology 43

      Pages: 1013-1020

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinoma2005

    • Author(s)
      Jinushi M., Tatsumi T., et al.
    • Journal Title

      Journal of Hepatology 43

      Pages: 1013-1020

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] EphA2 as a Glioma-Associated Antigen : A Novel Target for Glioma Vaccines2005

    • Author(s)
      Hatano M., Tatsumi T., et al.
    • Journal Title

      Neoplasia 7

      Pages: 717-722

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Expression of EphA2 is prognostic of disease-free interval and overall survivals in surgically treated patients with renal cell carcinoma2005

    • Author(s)
      Herrem C.J., Tatsumi T., et al.
    • Journal Title

      Clinical Cancer Research 11

      Pages: 226-231

    • Data Source
      KAKENHI-PROJECT-17590638
  • [Journal Article] Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection.2004

    • Author(s)
      Jinushi M, Takehara T, Tatsumi T, Kanto T, Miyagi T, Suzuki T, Kanazawa Y, Hiramatsu N, Hayashi N.
    • Journal Title

      Journal of Immunology 173

      Pages: 6072-6081

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Concanavarin A injection activates intrahepatic innate immune cells to provoke an anti-tumor effect in murine liver.2004

    • Author(s)
      Miyagi T, Takehara T, Tatsumi T, Suzuki T, Jinushi M, Kanazawa Y, Hiramatsu N, Kanto T, Tsuji S, Hori M, Hayashi N.
    • Journal Title

      Hepatology 40

      Pages: 1190-1196

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.2004

    • Author(s)
      Takehara T, Tatsumi T, Suzuki T, Rucker III EB, Hennighausen L, Jinushi M, Miyagi T, Kanazawa Y, Hayashi N.
    • Journal Title

      Gastroenterology 127

      Pages: 1189-1197

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.2004

    • Author(s)
      Takehara T, Tatsumi T, et al.
    • Journal Title

      Gastroenterology 127

      Pages: 1189-1197

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390207
  • [Journal Article] Differential alteration of CD56-bright and CD56-dim NK cells in frequency, phenotype and cytokine response in patients with chronic hepatitis C virus infection.

    • Author(s)
      Miyagi T, Shimizu S, Nishio K, Tatsumi T, Hiramatsu N, Kanto T, Hayashi N, Takehara T.
    • Journal Title

      J Gastroenterol in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Journal Article] Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells.

    • Author(s)
      Tsunematsu H, Tatsumi T, Kohga K, Yamamoto M, Aketa H, Miyagi T, Hosui A, Hiramatsu N, Kanto T, Hayashi N, Takehara T.
    • Journal Title

      Int J Cancer in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Presentation] Activation of hepatocyte p53 triggers acute liver failure with multiple organ injury.2023

    • Author(s)
      Jihyun Sung, Hayato Hikita, Yuki Makino, Seiya Kato, Yoichi Sasaki, Kenji Fukumoto, Kazuhiro Murai, Kunimaro Furuta, Akira Nishio, Takahiro Kodama, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      AASLD2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02903
  • [Presentation] Immunokinetic Analysis Predicts Efficacy of Combination Immunotherapy for Advanced Hepatocellular Carcinoma2023

    • Author(s)
      Takahiro Kodama, Shuhei Yamamoto, Akira Nishio, Kazuki Maesaka, Akira Doi, Yuki Tahata, Hayato Hikita, Tomohide Tatsumi, Tetsuro Takehara
    • Organizer
      APASL Oncology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法の治療効果予測バイオマーカー としてのIL-6の有用性2022

    • Author(s)
      松前高幸、小玉尚宏、阪森亮太郎、前阪和城、野﨑泰俊、俵誠一、田中聡司、宮﨑昌典、澤井良之、藥師神崇行、大川和良、三田英治、萩原秀紀、今井康陽、田畑優貴、山田涼子、疋田隼人、巽智秀、竹原徹郎
    • Organizer
      第26回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法における、リキッドバイオプシーを用いた治療効果予測2022

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Sustained hepatocyte p53 activation induces non-cell autonomous liver carcinogenesis2022

    • Author(s)
      Hayato Hikita, Yuki Makino, Kenji Fukumoto, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      APASL Oncology 2022 in Takamatsu
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02903
  • [Presentation] 肝細胞癌薬物療法効果予測バイオマーカーとしての血清ST6GAL1の有用性2021

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor2021

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AACR ANNUAL MEETING 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Biomarker-driven precision medicine for hepatocellular carcinoma2021

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第80回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Activation of tumor suppressor p53 in hepatocytes paradoxically promotes liver carcinogenesis derived from hepatic progenitor cells.2021

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      SH International Liver Conference 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02903
  • [Presentation] 切除不能肝細胞癌に対するアテゾリズマブ/ベバシズマブ併用療法の初期治療成績2021

    • Author(s)
      前阪 和城、阪森 亮太郎、山田 涼子、田畑 優貴、小玉 尚宏、疋田 隼人、今井 康陽、尾下 正秀、大川 和良、三田 英治、伊藤 敏文、萩原 秀紀、藥師神 崇行、巽 智秀、竹原 徹郎
    • Organizer
      第24回日本肝癌分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 進行肝細胞癌に対するラムシルマブとソラフェニブの比較検討:多施設共同研究2021

    • Author(s)
      前阪 和城、阪森 亮太郎、山田 涼子、田畑 優貴、小玉 尚宏、疋田 隼人、大川 和良、尾下 正秀、田村 信司、萩原 秀紀、三田 英治、藥師神 崇行、稲田 正己、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝類洞内皮細胞が産生する CTGF による肝星細胞の活性化と線維化進展2021

    • Author(s)
      佐々木 陽一、疋田 隼人、牧野 祐紀、小玉 尚宏、阪森 亮太郎、巽 智秀、竹原 徹郎
    • Organizer
      第35回肝類洞壁細胞研究会学術集会
    • Data Source
      KAKENHI-PROJECT-21H02903
  • [Presentation] Constitutive activation of hepatocyte p53 paradoxically promotes liver carcinogenesis derived from hepatic progenitor cells2021

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02903
  • [Presentation] プール型CRISPRライブラリースクリーニングによる肝がんレゴラフェニブ効果予測マーカーの探索2020

    • Author(s)
      小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第21回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝星細胞がオートファジー依存的に分泌するGDF15は肝細胞癌の進展に寄与する2020

    • Author(s)
      明神悠太、疋田隼人、小玉尚宏、牧野祐紀、阪森亮太郎、巽智秀、溝上雅史、江口英利、竹原徹郎
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K08307
  • [Presentation] GDF15 secreted by hepatic stellate cells accelerates HCC progression in an autophagy-dependent manner2020

    • Author(s)
      Yuta Myojin, Hayato Hikita , Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307
  • [Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020

    • Author(s)
      Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
    • Organizer
      The Digital International Liver Congress of the European Association for the Study of the Liver
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307
  • [Presentation] In vivo oncogene library screen of predictive biomarkers for multi-kinase inhibitors in hepatocellular carcinoma2019

    • Author(s)
      小玉尚宏、明神悠太、山田涼子、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] In vivo rapid genetic screen of efficacy biomarkers for multi-kinase inhibitors in Hepatocellular carcinoma2019

    • Author(s)
      Takahiro Kodama , Yuta Myojin , Hayato Hikita , Ryotaro Sakamori , Tomohide Tatsumi , Tetsuo Takehara
    • Organizer
      JDDW 2019
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] CRISPR loss-of-function screen identifies the Hippo pathway as the potential efficacy biomarker of regorafenib in HCC2019

    • Author(s)
      Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第78回日本癌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝細胞癌においてHippo経路はレゴラフェニブの治療効果を修飾する2019

    • Author(s)
      小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第55回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] CRISPR LOSS-OF-FUNCTION SCREEN IDENTIFIES THE HIPPO SIGNALLING PATHWAY AS THE MEDIATOR OF REGORAFENIB EFFICACY IN HEPATOCELLULAR CARCINOMA2019

    • Author(s)
      Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 持続的肝細胞アポトーシスは、酸化ストレス依存的にジエチルニトロサミンによるDNA損傷を持続させ腫瘍形成を促進させる2019

    • Author(s)
      野﨑泰俊、疋田隼人、田中聡司、水谷直揮、明神悠太、坂根貞嗣、 牧野祐紀、中堀輔、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09423
  • [Presentation] 生体内forward genetic screenによる肝がんドライバー遺伝子の網羅的探索2019

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] In vivo rapid genetic screen of efficacy biomarker for multi-kinase inhibitors in hepatocellular carcinoma2019

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      JDDW2019
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] 肝細胞癌に対するレンバチニブの初期治療成績2019

    • Author(s)
      前阪和城、阪森亮太郎、山田涼子、中堀 輔、重川 稔、小玉尚宏、疋田隼人、巽 智秀、竹原徹郎
    • Organizer
      第20回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] 生体内forward genetic screenによる肝がんドライバー遺伝子の網羅的探索2019

    • Author(s)
      小玉尚宏、巽 智秀、竹原徹郎
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] 慢性肝疾患におけるマクロファージ由来TNF-αは肝細胞における非アポトーシス型の肝細胞死誘導と酸化ストレス誘導により肝発癌を促進する2019

    • Author(s)
      齋藤 義修,疋田 隼人,工藤 慎之輔,野崎 泰俊,牧野 祐紀,中堀 輔,山田涼子,小玉 尚宏,阪森 亮太郎,巽 智秀,竹原 徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09423
  • [Presentation] プール型全ゲノムCRISPR/Casライブラリーを用いた肝癌新規癌抑制遺伝子とソラフェニブ感受性因子探索2018

    • Author(s)
      小玉 尚宏、疋田 隼人, 阪森 亮太郎, 巽 智秀, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] トランスポゾンスクリーニングを用いたNASH由来肝癌ドライバー遺伝子の網羅的探索2018

    • Author(s)
      小玉 尚宏, 巽 智秀, 竹原 徹郎
    • Organizer
      第104回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 放射線肝限局照射モデルマウスを用いた肝再生能の検討2018

    • Author(s)
      占部真貴子、疋田隼人、齋藤義修、小玉尚宏、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第54回 日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-16K15430
  • [Presentation] C型慢性肝炎ではCEACAM1によりNK細胞活性が抑制される2018

    • Author(s)
      須田 貴広, 巽 智秀, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] 肝がんにおける新規癌抑制遺伝子RNF125の同定と機能解析2018

    • Author(s)
      小玉 尚宏, 末村 茂樹, 村井 大毅, 疋田 隼人, 阪森 亮太郎, 巽 智秀, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝細胞DNase IIはアポトーシス刺激下においてTLR9/IFN-β経路を介した非アポトーシス細胞死を制御する2018

    • Author(s)
      齋藤 義修,疋田 隼人,甲斐 優吾,野崎 泰俊,牧野 祐紀,中堀 輔,小玉 尚宏,阪森 亮太郎,巽 智秀,竹原 徹郎
    • Organizer
      第54回 日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09423
  • [Presentation] Suppression of DNase II activity in fatty livers contributes to induction of RIP1-dependent hepatocyte necrosis through TLR9-IFNβ pathway.2017

    • Author(s)
      Yoshinobu Saito, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Yuki Makino, Tasuku Nakabori, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD 2017 The Liver meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09423
  • [Presentation] Hippo経路の破綻は脂肪性肝疾患からの肝癌発症のドライバーである2017

    • Author(s)
      小玉尚宏、巽智秀、竹原徹郎
    • Organizer
      JDDW2017
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Autophagic changes of both adipose tissues and the liver induced by high fat diet feeding contribute to hepatic lipid accumulation2017

    • Author(s)
      Sadatsugu Sakane, Hayato Hikita, Satoshi Tanaka, Kumiko Shirai, Naoki Mizutani, Yuta Myojin, Yuto Shiode, Yasutoshi Nozaki, Yoshinobu Saito, Tasuku Nakabori, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] 肝臓と脂肪組織のオートファジーによる脂肪蓄積制御2017

    • Author(s)
      坂根 貞嗣、疋田 隼人、田中 聡司、明神 悠太、塩出 悠登、野崎 泰俊、齋藤 義修、中堀 輔、小玉 尚弘、阪森 亮太郎、巽 智秀、竹原 徹郎
    • Organizer
      第1回消化器臓器間ネットワーク研究会
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] Intake of high fat diet causes suppression of hepatocyte autophagy and enhancement of adipocyte autophagy and controls fat deposition of liver and adipose tissue2017

    • Author(s)
      Sadatsugu Sakane, Hayato Hikita, Satoshi Tanaka, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tsuyoshi Kawabata, Maho Hamasaki, Tamotsu Yoshimori, Tetsuo Takehara
    • Organizer
      The 8th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] 肝臓と脂肪組織のオートファジーによる肝脂肪蓄積制御2017

    • Author(s)
      坂根 貞嗣、疋田 隼人、田中 聡司、明神 悠太、塩出 悠登、野崎 泰俊、齋藤 義修、中堀 輔、小玉 尚宏、阪森 亮太郎、巽 智秀、竹原 徹郎
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] NAFLDの病態における肝細胞DNaseIIの役割2017

    • Author(s)
      齋藤 義修,疋田 隼人,甲斐 優吾,野崎 泰俊,牧野 祐紀,中堀 輔,田中 聡司,小玉 尚宏,阪森 亮太郎,巽 智秀,竹原 徹郎
    • Organizer
      第59回日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-17K09423
  • [Presentation] Significance of the up-regulation of connective tissue growth factor in hepatocellular carcinoma2016

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Minoru Shigekawa, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, and Tetsuo Takehara
    • Organizer
      The 25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Autophagy Impairment in Pancreatic Acinar Cells Induces Accuulation of Zymogen Granules2016

    • Author(s)
      Kiyoshi Iwahashi, Hayato Hikita, Minoru Shigekawa, Kenji Ikezawa, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-05-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15429
  • [Presentation] C型慢性肝疾患における血清中フコシル化ハプトグロビンおよびMac-2 binding proteinの臨床的意義2015

    • Author(s)
      俵誠一、巽智秀、青野悟志、大西良輝、西尾啓、重川稔、疋田隼人、阪森亮太郎、飯尾禎元、小林一三、三善英知、竹原徹郎.
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Presentation] NK cells play important roles in the pathogenesis of HBV infection via alternation of NKp46high NKG2Ahigh subset2015

    • Author(s)
      Teppei Yoshioka, Yoshinobu Yokoyama, Akira Nishio, Yoshiki Onishi, Kaori Mukai, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Naoki Hiramatsu, Takuya Miyagi, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      The 65th Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco(米国)
    • Year and Date
      2015-11-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma and its potential for therapeutic target2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 66th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] B型慢性肝炎の病態と治療におけるNK細胞レセプターの意義2015

    • Author(s)
      吉岡鉄平、宮城琢也、向井香織、横山恵信、西尾啓、名和誉敏、疋田隼人、阪森亮太郎、平松直樹、巽智秀、竹原徹郎
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 3rd JSGE International Topic Conference
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-04-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Enhanced expression of Rubicon inhibits autophagy and promotes apoptosis by increasing endoplasmic reticulum stress in nonalcoholic fatty liver disease.2015

    • Author(s)
      Satoshi Tanaka, Hayato Hikita, Sadatsugu Sakane, Yasutoshi Nozaki, Yugo Kai, Tasuku Nakabori, Yoshinobu Saito, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 66th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] Evaluation of both Fucosylated haptoglobin and Mac-2 binding protein as new biomarkers to estimate liver fibrosis in chronic hepatitis C patients2015

    • Author(s)
      Seiichi Tawara, Tomohide Tatsumi, Sadaharu Iio, Ichizo Kobayashi, Shigeki Suemura, Atsuo Takigawa, Tadashi Kegasawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Akira Nishio, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Naoki Hiramatsu, Eiji Miyoshi, Tetsuo Takehara.
    • Organizer
      The 65th Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco(米国)
    • Year and Date
      2015-11-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460993
  • [Presentation] 肝細胞癌におけるRas経路とCTGFの意義・新規治療標的としての可能性2015

    • Author(s)
      牧野祐紀 疋田隼人 川口司 甲斐優吾 野崎泰俊 中堀輔 齋藤義修 田中聡司 重川稔 小玉尚宏 阪森亮太郎 宮城琢也 巽智秀 竹原徹郎
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] 非アルコール性脂肪肝炎病態形成における、オートファジー制御蛋白Rubiconの役割2015

    • Author(s)
      田中 聡司、疋田 隼人、野崎 泰俊、甲斐 優吾、牧野 祐紀、中堀 輔、齋藤 義修、阪森 亮太郎、巽 智秀、竹原 徹郎
    • Organizer
      第22回 肝細胞研究会
    • Place of Presentation
      米子
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] Role of connective tissue growth factor in hepatocellular carcinoma2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Yasutoshi Nozaki, Kenji Ikezawa, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      日本癌学会第74回総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Involvement of CXCL1-S100A8 loop via CXCR2 in the development of nonalcoholic fatty liver disease.2014

    • Author(s)
      Kaori Mukai, Takuya Miyagi, Yoshinobu Yokoyama, Teppei Yoshioka,Kumiko Nishio, ,Akira Nishio, Yoshiki Onishi, Satoshi Aono, Yoshinobu Saito, Satoshi Tanaka, Hayato Hikita, Ryotaro Sakamori, Naoki Hiramatsu, Harumasa Yoshihara, Yasuharu Imai, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      The 65th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-25460992
  • [Presentation] Activation of mitochondrial apoptotic pathway increases oxidative stress in hepatocytes leading to liver carcinogenesis2014

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Minoru Shigekawa, Yoshito Hayashi, Ryotaro Sakamori, Takuya Miyagi, Tetsuo Takehara
    • Organizer
      日本癌学会第73回総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] NASH病態形成におけるオートファジーとアポトーシスの意義2014

    • Author(s)
      田中聡司、 疋田隼人、 牧野祐紀、 中堀輔、 齋藤義修、 阪森亮太郎、宮城琢也、 巽智秀、 竹原徹郎
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-25
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] Cdc42は腸管における癌幹細胞のニッチ形成に関与する2014

    • Author(s)
      阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第56回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23
    • Data Source
      KAKENHI-PROJECT-26461002
  • [Presentation] Significance of connective tissue growth factor (CTGF) for the oncogenesis and progression of hepatocellular carcinoma2014

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      日本癌学会第73回総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Activation of mitochondrial pathway of apoptosis in hepatocytes increases oxidative stress in hepatocytes leading to liver tumorigenesis2014

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
    • Organizer
      The 65th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Increased expression of Rubicon protein by high fat diet suppresses autophagic flux and induces apoptosis by increasing endoplasmic reticulum stress in the pathogenesis of non-alcoholic fatty liver disease2014

    • Author(s)
      Satoshi Tanaka, Hayato Hikita, Yasutoshi Nozaki, Yugo Kai, Tasuku Nakabori, Yoshinobu Saito, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 65th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] 脂肪肝炎におけるオートファジー制御タンパクRubicon発現上昇を介した肝細胞アポトーシスの亢進2014

    • Author(s)
      田中 聡司、疋田 隼人、野崎 泰俊、甲斐 優吾、牧野 祐紀、中堀 輔、齋藤 義修、阪森 亮太郎、宮城 琢也、巽 智秀、竹原 徹郎
    • Organizer
      第21回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-27
    • Data Source
      KAKENHI-PROJECT-26253047
  • [Presentation] Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma2014

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] 肝障害における金属元素の役割」「肝細胞アポトーシスが惹起するミトコンドリア障害は、酸化ストレスを介して肝発癌を誘導する2014

    • Author(s)
      疋田隼人 巽智秀 竹原徹郎
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Continuous apoptosis in hepatocytes induces oxidative stress and leads to liver carcinogenesis.2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Tasuku Nakabori, Yoshinobu Saito, Tsukasa Kawaguchi, Satoshi Tanaka, Satoshi Shimizu, Ryotaro Sakamori, Takuya Miyagi, Tetsuo Takehara.
    • Organizer
      The 17th International Symposium on Cell of the Hepatic Sinusoid.
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] 肝腫瘍に対するα-Galactosylceramideと5-Fluorouracil併用による免疫化学療法の有用性2013

    • Author(s)
      明田寛史、巽 智秀、大西良輝、青野悟志、常松日奈子、疋田隼人、阪森亮太郎、宮城琢也、平松直樹、考藤達哉、林 紀夫、竹原徹郎
    • Organizer
      肝臓学会総会 (第49回)
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease.2013

    • Author(s)
      Satoshi Tanaka, Hayato Hikita, Tasuku Nakabori, Yoshinobu Saito, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara.
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease.
    • Place of Presentation
      Washington D.C., USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] Antioxidant has a therapeutic potential for HCC driven by chronic liver injury.2013

    • Author(s)
      Hikita H, Tanaka S, Saito Y, Kawaguchi T, Shimizu S, Shigekawa M, Kodama T, Li W, Sakamori R, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T
    • Organizer
      The 2nd JSGE International Topic Conference.
    • Place of Presentation
      Kagoshima
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status.2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease.
    • Place of Presentation
      Washington, USA
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] NASH 肝障害・肝発癌の病態形成における, オートファジー抑制を介した持続的アポトーシスの寄与2013

    • Author(s)
      田中聡司, 疋田隼人, 齋藤義修, 清水聡, 阪森亮太郎, 宮城琢也, 巽智秀, 竹原徹郎
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status.2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
    • Organizer
      American Association of the Study of Liver Disease 64th
    • Place of Presentation
      米国ワシントンDC
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013

    • Author(s)
      疋田隼人, 巽智秀, 宮城琢也, 阪森亮太郎, 清水聡, 斉藤義修, 田中聡司, 竹原徹郎
    • Organizer
      第49回肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] .Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status.2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara.
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease.
    • Place of Presentation
      Washington D.C., USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] Continuous apoptosis in hepatocytes induces liver tumors with DNA hypermethylation but not p53 or beta-catenin mutation.2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Yoshito Hayashi, Ryotaro Sakamori, Takuya Miyagi, Masahiko Tsujii, Tetsuo Takehara
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Immunological amplification of CXCL1-S100A8 loop via CXCR2-expressing CD11b+ Gr-1high cells in the development of nonalcoholic fatty liver disease.2013

    • Author(s)
      Kaori Mukai, Takuya Miyagi, Kumiko Nishio, Yoshinobu Yokoyama, Teppei Yoshioka, Yoshinobu Saito, Tsukasa Kawaguchi, Satoshi Aono, Satoshi Tanaka, Satoshi Shimizu, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease.
    • Place of Presentation
      Washington, USA
    • Data Source
      KAKENHI-PROJECT-25460992
  • [Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013

    • Author(s)
      疋田隼人, 巽智秀, 中堀輔, 斎藤義修, 田中聡司, 清水聡, 阪森亮太郎, 宮城拓也, 竹原徹郎
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] The rheostat regulating hepatocyte apoptosis by BH3-only proteins in developing and adult liver.2013

    • Author(s)
      Hayato Hikita, Yoshinobu Saito, Satoshi Tanaka, Kawaguchi Tsukawa, Satoshi Shimizu, Takahiro Kodama, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      The 20th Annual Meeting of the Japanese Society for the Reserch of Hepatic Cells.
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013

    • Author(s)
      疋田隼人、巽智秀、中堀輔、斎藤義修、田中聡司、清水聡、阪森亮太郎、宮城拓也、竹原徹郎
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013

    • Author(s)
      疋田隼人、巽智秀、宮城琢也、阪森亮太郎、清水聡、斉藤義修、田中聡司、竹原徹郎
    • Organizer
      第49回肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Oxidative stress induced by continuous hepatocyte apoptosis drives liver carcinogenesis independently of regeneration and DNA methylation status2013

    • Author(s)
      Hayato Hikita, Tomohide Tatsumi, Yoshinobu Saito, Satoshi Tanaka, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Washington, USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013

    • Author(s)
      疋田隼人、巽智秀、宮城琢也、阪森亮太郎、清水聡、斉藤義修、田中聡司、竹原徹郎
    • Organizer
      第49回肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] NASH肝障害・肝発癌の病態形成における、オートファジー抑制を介した持続的アポトーシスの寄与2013

    • Author(s)
      田中聡司、疋田隼人、齋藤義修、清水聡、阪森亮太郎、宮城琢也、巽智秀、竹原徹郎.
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] A novel hepato-proliferative effect of carbamazepine during liver regeneration2013

    • Author(s)
      Tsukasa Kawaguchi, Takahiro Kodama, Satoshi Tanaka, Kaori Mukai, Satoshi Aono, Minoru Shigekawa, Satoshi Shimizu, Hayato Hikita, Wei Li, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      American Association of the Study of Liver Disease 64th
    • Place of Presentation
      米国ワシントンDC
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease2013

    • Author(s)
      Satoshi Tanaka, Hayato Hikita, Tasuku Nakabori, Yoshinobu Saito, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 64th Annual Meeting of the American Association for the study of Liver Disease. The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease
    • Place of Presentation
      Washington, USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] Hepatitis C virus infection reduces chemo-sensitivity of the hepatocellular carcinoma cells through enhancing cancer stem cell characters.2013

    • Author(s)
      Takatoshi Nawa, Tomohide Tatsumi, Akira Nishio, Seiichi Tawara, Yoshiki Ohnishi, Satoshi Aono, Satoshi Shimizu, Hayato Hikita, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
    • Organizer
      American Association of the Study of Liver Disease 64th
    • Place of Presentation
      米国ワシントンDC
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] NAFLD/NASH 病態形成における, 飽和脂肪酸・不飽和脂肪酸によるオートファジーとアポトーシスの制御に関して2013

    • Author(s)
      田中聡司, 疋田隼人, 齋藤義修, 清水聡, 阪森亮太郎, 宮城琢也, 巽智秀, 竹原徹郎
    • Organizer
      第49回肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] 肝細胞アポトーシスが発生する酸化ストレスの肝発癌に与える影響2013

    • Author(s)
      疋田隼人、巽 智秀、宮城琢也、齋藤義修、田中聡司、清水 聡、阪森亮太郎、平松直樹、竹原徹郎
    • Organizer
      肝臓学会総会 (第49回)
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] NAFLD/NASH病態形成における、飽和脂肪酸・不飽和脂肪酸によるオートファジーとアポトーシスの制御に関して.2013

    • Author(s)
      田中聡司、疋田隼人、齋藤義修、清水聡、阪森亮太郎、宮城琢也、巽智秀、竹原徹郎
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] 慢性肝障害からの肝発癌におけるバイオマーカーの検討2013

    • Author(s)
      疋田隼人、巽智秀、中堀輔、斎藤義修、田中聡司、清水聡、阪森亮太郎、宮城拓也、竹原徹郎
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] 自己免疫性肝炎におけるNKT細胞の関与2012

    • Author(s)
      西尾公美子、宮城琢也、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Differential roles of palmitic acid and oleic acid in regulation of apoptosis and autophagy in non-alcoholic fatty liver disease2012

    • Author(s)
      Satoshi Tanaka, Hayato Hikita1, Satoshi Aono, Tsukasa Kawaguchi, Kaori Mukai, Satoshi Shimizu, Takahiro Kodama, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 63rd Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] The BH3-only proteins, Bim and Bid, constitutively participate in the healthy Bcl-2 rheostat regulating hepatocyte life and death via the mitochondrial pathway of apoptosis2012

    • Author(s)
      Kodama T, Hikita H, Tatsumi T, et al.
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞p53による肝線維化誘導機構の解析2012

    • Author(s)
      小玉尚宏、巽 智秀、竹原徹郎
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Ras経路が活性化されている肝細胞癌においてSTAT3シグナルは有用な治療ターゲットとなりうる2012

    • Author(s)
      重川 稔、疋田隼人、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] NKG2Dリガンド制御による肝癌免疫化学療法の可能性2012

    • Author(s)
      巽 智秀、甲賀啓介、竹原徹郎
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] ミトコンドリア介在性アポトーシスによる成熟肝細胞の恒常性制御機構の解明2012

    • Author(s)
      小玉尚宏、川口 司、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞アポトーシスの持続によるマクロファージの活性化と肝発癌.2012

    • Author(s)
      疋田隼人, 巽智秀, 竹原徹郎.
    • Organizer
      第98回日本消化器病学会総会.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Differential roles of palmitic acid and oleic acid in regulation of apoptosis and autophagy in non-alcoholic fatty liver disease2012

    • Author(s)
      Tanaka S, Hikita H, Tatsumi T, et al.
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Bid and Bim are essential regulators involving the intrinsic pathway of apoptosis in hepatocytes in the absence of anti-apoptotic Bcl-2 family proteins2012

    • Author(s)
      Takahiro Kodama, Hayato Hikita, Tsukasa Kawaguchi, Hinako Tsunematsu, Kumiko Nishio, Takatoshi Nawa, Minoru Shigekawa, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Tetsuo Takehara
    • Organizer
      The 63rd Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver.2012

    • Author(s)
      Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi,Tetsuo Takehara.
    • Organizer
      The 63rd Annual Meeting of the American Association for the study of Liver Disease.
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] Interleukin-17 producing γδT cell is responsible for iNKT cell deficiency-induced liver inflammation2012

    • Author(s)
      Nishio K, Miyagi T, Tatsumi T, et al.
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver.2012

    • Author(s)
      Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi,Tetsuo Takehara.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] 肝癌に対する新規アジュバント疎水化ポリγ-グルタミン酸ナノ粒子を用いたペプチドワクチン2012

    • Author(s)
      巽 智秀、明石 満、竹原徹郎
    • Organizer
      JDDW2012第20回日本消化器関連学会週間、第16回肝臓学会大会
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞障害が誘導する酸化ストレスと肝発癌2012

    • Author(s)
      疋田隼人、巽 智秀、竹原徹郎
    • Organizer
      JDDW2012第20回日本消化器関連学会週間、第54回消化器病学会大会
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞のアポトーシスによる酸化ストレス発生と肝発癌2012

    • Author(s)
      疋田隼人、巽 智秀、小玉尚宏、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞のアポトーシスによる酸化ストレス発生と肝発癌2012

    • Author(s)
      疋田隼人, 巽智秀, 小玉尚宏, 清水聡, 重川稔, 田中聡司, 法水淳、宮城琢也、竹原徹郎.
    • Organizer
      第47回日本肝臓学会総会.
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] IFN治療がC型肝炎の肝メチル化に与える影響について2012

    • Author(s)
      清水 聡、巽 智秀、重川 稔、他
    • Organizer
      癌学会総会(第71回)
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] C型肝炎における肝メチル化の定量的評価2012

    • Author(s)
      清水 聡、小瀬嗣子、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver2012

    • Author(s)
      Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 63rd Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23390197
  • [Presentation] NK cells might deplete liver myeloid-derived suppressor cells via targeting NK activating molecules in metastatic liver tumor-bearing mice2012

    • Author(s)
      Aono S, Tatsumi T, Aketa H, et al.
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 非癌部のFAP発現は肝癌術後再発予測因子となりうる2012

    • Author(s)
      常松日奈子、巽 智秀、甲賀啓介、他
    • Organizer
      JDDW2012第20回日本消化器関連学会週間、第54回消化器病学会大会
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] マウス肝腫瘍に対する抗癌剤による免疫修飾とNK感受性の制御2012

    • Author(s)
      明田寛史、巽 智秀、青野悟志、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 先天性心疾患術後に発症した肝細胞癌の3例2012

    • Author(s)
      大西良輝、宮崎昌典、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] セルレイン急性膵炎モデルにおいて膵Stat3は保護的に働く2012

    • Author(s)
      重川 稔、巽 智秀、竹原徹郎
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Carbamazepine promotes liver regeneration in hepatectomized mice through activation of mTOR pathway2012

    • Author(s)
      Kawaguchi T, Kodama T, Tatsumi T, et al.
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Pancreatic STAT3 protects caerulein-induced acute pancreatitis in mice via the PAP1 induction2012

    • Author(s)
      Minoru Shigekawa, Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Takuya Miyagi, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi and Tetsuo Takehara.
    • Organizer
      DDW2012
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-24659364
  • [Presentation] 肝細胞アポトーシスの持続によるマクロファージの活性化と肝発癌2012

    • Author(s)
      疋田隼人、巽 智秀、竹原徹郎
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞アポトーシスの持続は、TNF-αを上昇させて肝発癌を誘導する2012

    • Author(s)
      疋田隼人、小玉尚宏、巽 智秀、他
    • Organizer
      癌学会総会(第71回)
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞癌におけるNK活性化レセプターリガンドの発現機構の解析2012

    • Author(s)
      甲賀啓介、巽 智秀、竹原徹郎
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Oxidative stresses play a major role in cancer development in apoptosis-prone liver2012

    • Author(s)
      Hikita H, Kodama T, Tatsumi T, et al
    • Organizer
      第63回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] PPARγおよびmir-20bを介したSTAT5-CD36-肝脂肪化の機序の検討2012

    • Author(s)
      法水 淳、巽 智秀、竹原徹郎
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] 肝細胞障害が誘導する酸化ストレスと肝発癌2012

    • Author(s)
      疋田隼人, 巽智秀, 竹原徹郎
    • Organizer
      第54回日本消化器病学会総会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24590970
  • [Presentation] 抗てんかん薬カルバマゼピンによる肝切除後肝再生促進機構の解析2012

    • Author(s)
      川口 司、小玉尚宏、巽 智秀、他
    • Organizer
      肝臓学会総会 (第48回)
    • Place of Presentation
      石川県金沢市
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Sorafenibは肝細胞癌のADAM9を抑制することで先天免疫応答を増強する2011

    • Author(s)
      甲賀啓介、巽智秀, 他
    • Organizer
      肝癌研究会(第47回)
    • Place of Presentation
      静岡県静岡市
    • Year and Date
      2011-07-28
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Delayed onset of caspase-dependent liver failure induced by Fas stimulation in Bak and Bax double knockout mice2011

    • Author(s)
      Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi, Tetsuo Takehara
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] IFNaはB型肝炎ウイルスのエンハンサー2の転写活性を阻害する2011

    • Author(s)
      名和誉敏、巽智秀, 他
    • Organizer
      第15回肝臓学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 持続的な肝細胞アポトーシスは肝発癌を誘導する2011

    • Author(s)
      疋田隼人、巽智秀、竹原徹郎
    • Organizer
      JDDW2011(第19回日本消化器関連学会週間、第53回消化器病学会大会、第15回肝臓学会大会、第9回消化器外科学会大会、第82回消化器内視鏡学会総会)
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Multi-kinase inhibitor sorafenib induces autophagy which confers anti-cancer drug resistance to human hepatoma cells2011

    • Author(s)
      Shimizu S, Tatsumi T, Takehara T(他9名)
    • Organizer
      第62回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Interferon-αsuppresses hepatitis B virus enhancer II activity via PKC pathway2011

    • Author(s)
      Nawa T, Tatsumi T, Takehara T(他9名)
    • Organizer
      第62回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞におけるp53の活性化は肝に線維化を誘導する2011

    • Author(s)
      小玉尚宏、巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] C型慢性肝炎のPEG-IFN/RBV併用治療における治療効果とC型肝炎ウイルス特異的細胞傷害性T細胞(CTL)免疫反応の関連2011

    • Author(s)
      巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 炎症性サイトカインInterleukin-1βは肝細胞癌の先天免疫回避に関与する2011

    • Author(s)
      巽智秀、竹原徹郎(他1名)
    • Organizer
      第47回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞におけるp53の活性化は肝に線維化を誘導する2011

    • Author(s)
      小玉尚宏、竹原徹郎、巽智秀(他10名)
    • Organizer
      第47回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Viral suppression at week 4 exceeds the IL28B SNP for predicting SVR in pegylated interferon plus ribavirin combination therapy of genotype 1 infected patients with chronic hepatitis C2011

    • Author(s)
      小瀬嗣子、巽智秀, 他
    • Organizer
      第62回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ市
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] IFNαはB型肝炎ウイルスのエンハンサー2の転写活性を阻害する2011

    • Author(s)
      名和誉敏、巽智秀、竹原徹郎(他4名)
    • Organizer
      JDDW2011(第19回日本消化器関連学会週間、第15回肝臓学会大会)
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] オートファジーは肝癌のソラフェニブ抵抗性の一因である2011

    • Author(s)
      清水聡、巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Requirement of BH3-only activator proteins Bid and Bim for apoptosis by genetic ablation of Bcl-xL is completely different between hepatocytes and platelets2011

    • Author(s)
      Takahiro Kodama, Hayato Hikita, Tsukasa Kawaguchi, Minoru Shigekawa, Hinako Tsunematsu, Kumiko Nishio, Takatoshi Nawa, Satoshi Shimizu, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Tetsuo Takehara
    • Organizer
      The 62nd Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] C型慢性肝炎のPEG-IFN/ RBV併用治療における治療効果とC型肝炎ウイルス特異的細胞傷害性T細胞(CTL)免疫反応の関連2011

    • Author(s)
      巽智秀、竹原徹郎(他6名)
    • Organizer
      第47回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] A crucial role of hepatocyte p53 in liver fibrogenesis2011

    • Author(s)
      Kodama T, Takehara T, Tatsumi T, (他10名)
    • Organizer
      DDW2011/ AGA/ AASLD
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2011-05-11
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Continuous hepatocyte apoptosis is sufficient for liver cancer development2011

    • Author(s)
      Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Satoshi Tanaka, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi, Tetsuo Takehara
    • Organizer
      The 62nd Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] Bak/ BaxダブルノックアウトマウスにおけるFasの活性化はカスパーゼ依存的な遅発性肝細胞死を誘導する2011

    • Author(s)
      疋田隼人、巽智秀、竹原徹郎(他9名)
    • Organizer
      第47回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 持続的な肝細胞アポトーシスは肝発癌を誘導する2011

    • Author(s)
      疋田隼人、巽智秀, 他
    • Organizer
      第53回消化器病学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 疎水化ポリγ-グルタミン酸ナノ粒子の癌抗原ペプチドワクチンにおけるアジュバントとしての有用性2011

    • Author(s)
      明田寛史、巽智秀、竹原徹郎(他17名)
    • Organizer
      JDDW2011(第19回日本消化器関連学会週間、第15回肝臓学会大会)
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Estimation of liver fibrosis by VTTQ (Virtual Tissue Touch Quantification) in chronic liver disease : the usefulness of Vs/plt2011

    • Author(s)
      山田涼子、巽智秀, 他
    • Organizer
      第62回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ市
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 難治性C型肝炎に対するPeg-IFN/RBV併用療法の治療効果とIL28B遺伝子多型との関連について-多施設(OLF)共同研究-2011

    • Author(s)
      小瀬嗣子、巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] A crucial role of hepatocyte p53 in liver fibrogenesis2011

    • Author(s)
      Takahiro Kodama, Tetsuo Takehara, Satoshi Shimizu, Hayato Hikita, Minoru Shigekawa, Hinako Tsunematsu, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] Bak/BaxダブルノックアウトマウスにおけるFasの活性化はカスパーゼ依存的な遅発性肝細胞死を誘導する2011

    • Author(s)
      疋田隼人、巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 炎症性サイトカインInterleukin-1βは肝細胞癌の先天免疫回避に関与する2011

    • Author(s)
      巽智秀, 他
    • Organizer
      肝臓学会総会(第47回)
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞特異的p53活性化マウスは肝線維化を自然発症する2011

    • Author(s)
      小玉尚宏、巽智秀, 他
    • Organizer
      第15回肝臓学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression2011

    • Author(s)
      法水淳、巽智秀, 他
    • Organizer
      第62回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ市
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Signal transducer and activator of transcription 3 signaling in hepatocytes protects from liver injury and fibrosis during chronic cholestasis in mice2010

    • Author(s)
      重川稔、巽智秀, 他
    • Organizer
      米国肝臓病学会
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-11-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] α-fetoproteinによるNK細胞活性化抑制2010

    • Author(s)
      山本政司、巽智秀, 他
    • Organizer
      JDDW2010、第52回消化器病学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Peg-IFN/Ribavirin併用療法の肝発癌抑制効果について-多施設(OLF)共同研究-2010

    • Author(s)
      小瀬嗣子、巽智秀, 他
    • Organizer
      肝臓学会総会 (第46回)
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] α-fetoproteinによる先天免疫活性化抑制機構の解析2010

    • Author(s)
      山本政司、巽智秀, 他
    • Organizer
      肝臓学会総会 (第46回)
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] CD133陽性肝細胞癌はmetalloproteinaseを制御しその生存に有利な環境を作る2010

    • Author(s)
      巽智秀、竹原徹郎(他7名)
    • Organizer
      第69回癌学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 血小板による肝線維化抑制機構の解明2010

    • Author(s)
      小玉尚宏、巽智秀, 他
    • Organizer
      JDDW2010、第52回消化器病学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus.2010

    • Author(s)
      黒川三佳、巽智秀, 他
    • Organizer
      米国肝臓病学会
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] FGF-2の肝癌発癌抑制効果2010

    • Author(s)
      常松日奈子、巽智秀, 他
    • Organizer
      JDDW2010、第52回消化器病学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Regulation of metalloproteinases in CD133 expressing human hepatocellular carcinoma cells2010

    • Author(s)
      巽智秀, 他
    • Organizer
      癌学会総会(第69回)
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] CD133陽性肝癌細胞のmetalloproteinaseによる制御2010

    • Author(s)
      巽智秀, 他
    • Organizer
      JDDW2010、第52回消化器病学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Red time PCR法を用いたHCV-RNA測定系におけるC型肝炎に対するPeg-IFN/RBV併用療法の治療効果予測2010

    • Author(s)
      小瀬嗣子、巽智秀, 他
    • Organizer
      肝臓学会総会 (第46回)
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Sorafenib regulates the shedding of MICA by inhibiting ADAM9 in hepatocellular carcinoma2010

    • Author(s)
      甲賀啓介、巽智秀, 他
    • Organizer
      癌学会総会(第69回)
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-21
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] ABT-737, a Bad mimetic Bcl-xL inhibitor, enhances the anti-tumor effect of sorafenib against hepatocellular carcinoma2010

    • Author(s)
      H. Hikita ; T. Takehara ; S. Shimizu ; T. Kodama ; W. Li ; M. Shigekawa ; A. Hosui ; T. Miyagi ; H. Ishida ; T. Tatsumi ; T. Kanto ; N. Hiramatsu ; N. Hayashi
    • Organizer
      The 61st Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] 血小板による肝線維化抑制機構の解明2010

    • Author(s)
      小玉尚宏、竹原徹郎、巽智秀(他8名)
    • Organizer
      JDDW2010(第18回日本消化器関連学会週間、第52回消化器病学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Sorafenibは肝細胞癌のADAM9は抑制することでMICAのsheddingを制御する2010

    • Author(s)
      甲賀啓介、巽智秀、竹原徹郎(他6名)
    • Organizer
      第69回癌学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2010-09-21
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞癌におけるADAMファミリーによる先天免疫応答制御機構の解析2010

    • Author(s)
      甲賀啓介、巽智秀, 他
    • Organizer
      JDDW2010、第52回消化器病学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] The role of IFN-STATI signal transduction on inhibition of HCC development2010

    • Author(s)
      法水淳、巽智秀, 他
    • Organizer
      米国肝臓病学会
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 「C型肝炎からの肝発がん」「IFN-STAT1活性化が肝癌進展に及ぼす影響の検討」「Sorafenibは肝細胞癌のADAM9を抑制することでMICAのsheddingを制御する」「CD133陽性肝細胞癌はmetalloproteinaseを制御しその生存に有利な環境を作る」2010

    • Author(s)
      竹原徹郎, 法水淳, 竹原徹郎, 他, 甲賀啓介, 竹原徹郎, 他, 巽智秀, 竹原徹郎, 他
    • Organizer
      第69回日本癌学会学術総会(シンポジウム2ウイルス発がん)
    • Place of Presentation
      大阪国際会議場リーガロイヤルホテル
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Presentation] α-fetoproteinによる先天免疫活性化抑制機構の解析2010

    • Author(s)
      山本政司、巽智秀、竹原徹郎(他7名)
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形県山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] CD133陽性肝癌細胞のmetalloproteinaseによる制御2010

    • Author(s)
      巽智秀、竹原徹郎(他1名)
    • Organizer
      JDDW2010(第18回日本消化器関連学会週間、第52回消化器病学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] The role of IFN-STAT1 signal transduction on inhibition of HCC development2010

    • Author(s)
      Hosui A, Takehara T, Tatsumi T(他9名)
    • Organizer
      第61回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 長期経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例におけるHBV全塩基配列の啓示的変化とその病態的意義についての検討2010

    • Author(s)
      大川和良、巽智秀, 他
    • Organizer
      肝臓学会総会 (第46回)
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Combination therapy with PegIFNα-2b and ribavirin in chronic hepatitis C patients with normal ALT levels : Matched case-control study by propensity score2009

    • Author(s)
      倉繁奈緒, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-01
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Reducing drug doses in genotype 1 patients with chronic hepatitis C during treatment with pegylated interferon alfa-2b plus ribavirin delays the timing of HCVRNA negativity or prevents its attainment ; a propensity score-matched study2009

    • Author(s)
      宋昌浩, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-01
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 9年間の経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例における各種HBVマーカー全塩基は入れるの経時的検討2009

    • Author(s)
      大川和良, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] α-fetoprotein impairs NK activity by inhibiting dendritic cell function2009

    • Author(s)
      Yamamoto M, Tatsumi T, Takehara T(他4名)
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2009-12-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Anti-cancer chemotherapy enhances NK sensitivity by inhibiting MICA ectodomain shedding in human hepatocellular carcinoma2009

    • Author(s)
      Kohga K, Tatsumi T, Takehara T(他4名)
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 血小板減少は胆汁鬱滞性肝障害における肝繊維化を増悪させる2009

    • Author(s)
      小玉尚宏, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Interferon-α-signaling in natural killer cells is impaired in chronic hepatitis C virus infection2009

    • Author(s)
      Miyagi T, Takehara T, Tatsumi T, (他4名)
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2009-11-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞癌におけるマイクロRNAによるBcl-xLの発現制御2009

    • Author(s)
      清水聡, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 血小板減少は胆汁鬱滞性肝障害における肝繊維化を増悪させる2009

    • Author(s)
      小玉尚宏、竹原徹郎、巽智秀(他10名)
    • Organizer
      第45回肝臓学会総会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Bcl-xL and Mcl-1 cooperate to maintain integrity of hepatocytes2009

    • Author(s)
      疋田隼人, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-01
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝繊維化進展C型肝炎に対する pegIFN/RBV併用療法における治療効果関連因子の検討2009

    • Author(s)
      小瀬嗣子, 巽智秀, 他
    • Organizer
      消化器病学会総会 (第95回)
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] The let7c family of micro RNAs negatively regulates Bcl-xL expression in human hepatocellular carcinoma2009

    • Author(s)
      清水聡, 巽智秀, 他
    • Organizer
      癌学会総会 (第68回)
    • Place of Presentation
      横浜国際会議場 (神奈川県)
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞癌におけるNK活性化レセプターリガンドMICA分泌(shedding)の分子機構2009

    • Author(s)
      甲賀啓介、竹原徹郎、巽智秀(他12名)
    • Organizer
      第45回肝臓学会総会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Anti-cancer chemotherapy enhances NK sensitivity by inhibiting MICA ectodomain shedding in human hepatocellular carcinoma2009

    • Author(s)
      甲賀啓介, 巽智秀, 他
    • Organizer
      日本免疫学会 (第39回)
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 非アルコール性脂肪性肝炎病態形成におけるNKT細胞の関与2009

    • Author(s)
      宮城琢也, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] ALT正常C型慢性肝炎に対するPegIFN/Rivavirin 併用療法の治療効果について-matched case-control study-2009

    • Author(s)
      倉繁奈緒, 巽智秀, 他
    • Organizer
      JDDW2009日本肝臓学会大会 (第13回)
    • Place of Presentation
      京都国際会議場 (京都府)
    • Year and Date
      2009-10-14
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 炎症性貧血は肝細胞STAT3が制御する2009

    • Author(s)
      阪森亮太郎, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Mcl-1とBcl-xLは肝細胞における主要なアポトーシス制御分子である2009

    • Author(s)
      疋田隼人, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Thrombocytopenia deteriorates cholestasis-induced liver fibrosis in mice2009

    • Author(s)
      Kodama T, Takehara T, Hikita H, Shimizu S, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Tadokoro S, Ido A, Tsubouchi H, Hayashi N
    • Organizer
      The 60th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-21659188
  • [Presentation] γ-PGAナノ粒子を用いた癌免疫療法の基礎的検討2009

    • Author(s)
      山口真二郎, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] 肝細胞癌におけるNK活性化レセプターリガンドMICA分泌 (shedding) の分子機構2009

    • Author(s)
      甲賀啓介, 巽智秀, 他
    • Organizer
      肝臓学会総会 (第45回)
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Lack of invariant natural killer T cells elicits liver inflammation and predisposes to liver fibrosis in mice fed with high-fat diet2009

    • Author(s)
      西尾久美子, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] α-fetoprotein impairs NK activity by inhibiting dendritic cell function2009

    • Author(s)
      山本政司, 巽智秀, 他
    • Organizer
      日本免疫学会 (第39回)
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Year and Date
      2009-12-03
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Interferon-α-signaling in natural killer cells is impaired in chronic hepatitis C virus infection2009

    • Author(s)
      宮城琢也, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Thrombocytopenia deteriorates cholestasis-induced liver fibrosis in mice2009

    • Author(s)
      小玉尚宏, 巽智秀, 他
    • Organizer
      第60回米国肝臓学会
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2009-11-02
    • Data Source
      KAKENHI-PROJECT-21590841
  • [Presentation] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with chronic hepatitis C responding to pegylated interferon alfa-2b plus ribavirin.2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] BH3-only protein Bid isrequired for hepatocyte apoptosiscaused by Bcl-xL deficiency2008

    • Author(s)
      Hikita H, Takehara T, Tatsumi T, (他10名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Expression of NKG2D activatingreceptor on natural killer cells inchronic hepatitis C.2008

    • Author(s)
      Shimizu S, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Expression of NKG2D activating receptor on natural killer cells in chronic hepatitis C.2008

    • Author(s)
      清水 聡, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Peg-IFN/Ribavirin併用療法における高感度HCV-RNA測定法(TaqMan法)の有用性について2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] SN38 は肝癌細胞の可溶性NK 活性リガンドの分泌を抑制しNK 細胞感受性を増強させる2008

    • Author(s)
      甲賀啓介、竹原徹郎、巽智秀、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Efficacy of theimmunotherapy with γ-polyglutamicacid nanoparticles in mouse livertumor2008

    • Author(s)
      Yamaguchi S, Tatsumi T, Takehara T, ( 他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Extended treatment withpeginterferon alfa-2b and ribavirincombination therapy can suppress therelapse rate after treatment ofchronic hepatitis C genotype 1patients with late viral response2008

    • Author(s)
      Oze T, Tatsumi T, Takehara T, (他28名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Supportive activity of PreCoreand PreS2 viral genomic changesagainst replication ofLamivudine-resistant hepatitis Bvirus2008

    • Author(s)
      Ohkawa K, Takehara T, Tatsumi T, (他9名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-02
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 難治性C 型肝炎に対するPeg-IFN/Ribavirin 併用療法でのEVR 例における薬剤adherence の影響-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他18名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] SN38 inhibits the shedding of MHC class1-related chain A, a ligand of NKG2D immunoreceptor in human hepatocellular carcinoma cells.2008

    • Author(s)
      甲賀啓介, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] ラミブジン耐性B型肝炎ウイルス成立機転に対するprecoreならびにpreS2変異の補助的役割2008

    • Author(s)
      大川和良, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 難治性C 型肝炎に対するPeg-IFN/Ribavirin 長期投与の有用性について-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他17名)
    • Organizer
      第12回肝臓学会大会
    • Place of Presentation
      東京都港区
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] BcL-xL は生体内肝細胞におけるBid の恒常的活性化によるアポトーシスを抑制する2008

    • Author(s)
      疋田隼人、竹原徹郎、巽智秀、(他13名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Supportive activity of PreCore and PreS2 viral genomic changes against replication of Lamivudine-resistant hepatitis B virus.2008

    • Author(s)
      大川和良, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-02
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] ウイルス感染モデルを用いたインターフェロンの免疫細胞内におけるシグナル伝達機構の制御メカニズムに関する基礎的検討2008

    • Author(s)
      宮城琢也、竹原徹郎、巽智秀、(他2名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 皮下腫瘍担癌マウスにおける肝樹状細胞上CD1d分子発現低下による肝先天免疫の抑制2008

    • Author(s)
      巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Extended treatment with peginterferon alfa-2b and ribavirin combination therapy can suppress the relapse rate after treatment of chronic hepatitis C genotype 1 patients with late viral response.2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 「SN38は肝癌細胞の可溶型NK活性リガンドの分泌を抑制しNK細胞感受性を増強させる」「IL-12遺伝子による肝臓NK細胞の活性化および転移性肝腫瘍の治療効果にはリンパ球からのIFN・の産生が重要である」「皮下腫瘍担癌マウスにおける肝樹状細胞上CD1d分子発現低下による肝先天免疫の抑制」「肝先天免疫活性化による肝樹状細胞活性化機構の解析」「ウイルス感染モデルを用いたインターフェロンの免疫細胞内におけるシグナル伝達機構の制御メカニズムに関する基礎的検討」2008

    • Author(s)
      甲賀啓介, 竹原徹郎, 他, 植村彰夫, 竹原徹郎, 他, 巽智秀, 竹原徹郎, 他, 笹川哲, 竹原徹郎, 他, 宮城琢也, 竹原徹郎, 他
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛県県民文化会館、愛媛看護研修センター(松山)(ワークショップ3肝の発癌と進展における分子代謝学的研究)
    • Data Source
      KAKENHI-PROJECT-20390208
  • [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin併用療法でのEVR例における薬剤adherenceの影響-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Efficacy of the immunotherapy with γ-polyglutamic acid nanoparticles in mouse liver tumor.2008

    • Author(s)
      山口真二郎, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Activated liver dendritic cells are more immunogenic than spleen dendritic cells after α-GalCer treatment.2008

    • Author(s)
      笹川 哲, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] BH3-only protein Bid is required for hepatocyte apoptosis caused by Bcl-xL deficiency.2008

    • Author(s)
      疋田隼人, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 肝先天免疫活性化による肝樹状細胞活性化機構の解析2008

    • Author(s)
      笹川 哲、巽智秀、竹原徹郎、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] BcL-xLは生体内肝細胞におけるBidの恒常的活性化によるアポトーシスを抑制する2008

    • Author(s)
      疋田隼人, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] ウイルス感染モデルを用いたインターフェロンの免疫細胞内におけるシグナル伝達機構の抑制メカニズムに関する基礎的検討2008

    • Author(s)
      宮城琢也, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] IL-12遺伝子による肝臓NK細胞の活性化および転移性肝腫瘍治療効果にはリンパ球からの IFN-γ産生が重要である2008

    • Author(s)
      植村彰夫, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Critical role of IFNγ producedfrom NK cells in IL-12-mediated NKcell activation and anti-tumor effectin the liver2008

    • Author(s)
      Uemura A, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] ラミブジン耐性B 型肝炎ウイルス成立機転に対するprecore ならびにpreS2 変異の補助的役割2008

    • Author(s)
      大川和良、竹原徹郎、巽智秀、(他12名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 皮下腫瘍担癌マウスにおける肝樹状細胞上CD1d 分子発現低下による肝先天免疫の抑制2008

    • Author(s)
      巽智秀、竹原徹郎、(他13名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 難治性C型肝炎に対するPeg-IFN/Ribavirin長期投与の有用性について-多施設(OLF)共同研究-2008

    • Author(s)
      小瀬嗣子, 巽 智秀, 他
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Ribavirin dose reduction raisesrelapse rate dose-dependently ingenotype 1 patients with chronichepatitis C responding to pegylatedinterferon alfa-2b plus ribavirin2008

    • Author(s)
      Oze T, Tatsumi T, Takehara T, (他26名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Activated liver dendritic cellsare more immunogenic than spleendendritic cells after α-GalCertreatment2008

    • Author(s)
      Sasakawa A, Tatsumi T, Takehara T, (他11名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] SN38は肝癌細胞の可溶性NK活性リガンドの分泌を抑制しNK細胞感受性を増強させる2008

    • Author(s)
      甲賀啓介, 巽 智秀, 他
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] SN38 inhibits the shedding ofMHC class1-related chain A, a ligandof NKG2D immunoreceptor in humanhepatocellular carcinoma cells2008

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, (他14名)
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] IL-12 遺伝子による肝臓NK 細胞の活性化および転移性肝腫瘍治療効果にはリンパ球からのIFN-γ産生が重要である2008

    • Author(s)
      植村彰夫、竹原徹郎、巽智秀、(他11名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Critical role of IFNγ produced from NK cells in IL-12-mediated NK cell activation and anti-tumor effect in the liver.2008

    • Author(s)
      植村彰夫, 巽 智秀, 他
    • Organizer
      第59回米国肝臓学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2008-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Peg-IFN/Ribavirin 併用療法における高感度HCV-RNA 測定法(TaqMan 法)の有用性について2008

    • Author(s)
      小瀬嗣子、竹原徹郎、巽智秀、(他12名)
    • Organizer
      第44回肝臓学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Dendritic cell-based vaccines suppress liver tumor viaactivation of innate and acquired immunity2007

    • Author(s)
      阪森亮太郎、巽智秀、竹原徹郎、( 他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Regulation of the NKG2D immunoreceptor by soluble MICA during transcatheter arterial embolization for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、巽 智秀、他
    • Organizer
      第58回アメリカ肝臓学会総会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2007-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 樹状細胞投与による肝先天免疫の活性化と予防的肝癌免疫治療の検討2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他9名)
    • Organizer
      第93回消化器病学会総会
    • Place of Presentation
      青森県青森市
    • Year and Date
      2007-04-20
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 肝腫瘍に対する新規癌抗原EphA2を用いたDCワクチン療法の基礎的検討2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] IFN γ is critically required for IL12-mediated NK cell activation and anti-tumor effect in the liver2007

    • Author(s)
      Uemura A, Takehara T, Tatsumi T, ( 他10名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 肝腫瘍に対する新規癌抗原EphA2 を用いたDC ワクチン療法の基礎的検討2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他8名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Administration of α-galactosylceramide induces liver acquired immunity after liver tumor rejection2007

    • Author(s)
      巽智秀、竹原徹郎、(他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 肝臓におけるSTAT3の活性化は敗血症時のTNF-αの賛成を抑制し生存率を向上させる2007

    • Author(s)
      阪森亮太郎、巽智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Hepatic STAT3 attenuates systemic inflammatory response and lethality in septic mice.2007

    • Author(s)
      Sakamori R, Takehara T, Tatsumi T, (他7名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] α-galatosylceramideによる肝樹状細胞活性化機構の解析2007

    • Author(s)
      笹川 哲、巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] 樹状細胞投与による肝先天免疫の活性化と予防的肝癌免疫治療の検討2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第93回消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-20
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Regulation of the NKG2D immunoreceptor by soluble MICA during transcatheter arterial embolization for hepatocellular carcinoma2007

    • Author(s)
      Kohga, K., Takehara, T., Hikita, H., Sasakawa, A., Uemura, A., Sakamori, R., Yamaguchi, S., Tatsumi, T., Ohkawa, K., Kanto, T., Hiramatsu, N., Katayama, K., Kato, M., Hayashi, N
    • Organizer
      The American Association for the Study of Liver Diseases The 58th Annual Meeting AASLD
    • Place of Presentation
      Hynes Convention Center, Boston, MA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390216
  • [Presentation] 肝臓におけるSTAT3 の活性化は敗血症時のTNF-αの産生を抑制し生存率を向上させる2007

    • Author(s)
      阪森亮太郎、竹原徹郎、巽智秀、(他6名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Activation of liver dendritic cells by administration of α-galactosylceramide.2007

    • Author(s)
      笹川 哲、巽智秀、竹原徹郎、(他5名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Dendritic cell-based vaccines suppress liver tumor via activation of innate and acquired immunity2007

    • Author(s)
      阪森亮太郎、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Administration of α-galactosylceramide induces liver acquired immunity after liver tumor rejection2007

    • Author(s)
      巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Dynamic regulation of the NKG2D immunoreceptor expression by soluble MICA during TAE for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、竹原徹郎、巽智秀、 (他7名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Regulation of the NKG2D immunoreceptor by soluble MICA during transcatheter arterial embolizationfor hepatocellular carcinoma.2007

    • Author(s)
      Kohga K, Takehara T, Tatsumi T, (他11名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Year and Date
      2007-11-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Immunotherapy of murine colon cancer using receptor tyrosine kinase EnhA2 derived peptide-pulsed dendritic cell vaccines2007

    • Author(s)
      山口真二郎、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Soluble forms of human NKG2D ligands MICA/B increase in sera of patients with liver cirrhosis and HCC2007

    • Author(s)
      疋田隼人、竹原徹郎、巽智秀、 (他7名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Activation of liver dendritic cells by administration of α-galactosyl ceramide2007

    • Author(s)
      笹川 哲、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Dynamic regulation of the NKG2D immunoreceptor expression by soluble MICA during TAE for hepatocellular carcinoma2007

    • Author(s)
      甲賀啓介、巽 智秀、他
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] NKT細胞活性化を介した肝癌特異的獲得免疫の誘導2007

    • Author(s)
      巽 智秀、他
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Impact of reducing peginterferon alfa-2b and ribavirin on early viral response in genotype 1 infected patients with chronichepatitis C2007

    • Author(s)
      Oze T, Takehara T, Tatsumi T, (他22名)
    • Organizer
      第58回米国肝臓学会
    • Place of Presentation
      米国ボストン
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] α-galactosylceramide による肝樹状細胞活性化機構の解析2007

    • Author(s)
      笹川哲、竹原徹郎、巽智秀、(他9名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] NKT細胞活性化を介した肝癌特異的獲得免疫の誘導2007

    • Author(s)
      巽智秀、竹原徹郎、(他11名)
    • Organizer
      第43回肝臓学会総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2 derived peptide-pulsed dendritie cell vaccines2007

    • Author(s)
      山口真二郎、巽智秀、竹原徹郎、(他8名)
    • Organizer
      第66回癌学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-19590766
  • [Presentation] C型肝炎に対するテラプレビル3剤併用療法非著効例におけるシメプレビル3剤併用療法の有効性と耐性変異について

    • Author(s)
      森下直紀、平松直樹、原田直毅、山田涼子、名和誉敏、疋田隼人、小瀬嗣子、藥師神崇行、宮城琢也、吉田雄一、巽 智秀、大川和良、山田 晃、三田英治、伊藤敏文、稲田正巳、今井康陽、加藤道夫、竹原徹郎
    • Organizer
      JDDW2014 第18回肝臓学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2014-10-23 – 2014-10-26
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] C型慢性肝疾患に対するSimeprevir/PegIFN/Ribavirin併用療法におけるビリルビン上昇とITPA遺伝子多型について

    • Author(s)
      原田直毅、平松直樹、小瀬嗣子、森下直紀、山田涼子、藥師神崇行、佐治雪子、土井喜宣、山田幸則、福井弘幸、林 英二朗、加藤道夫、疋田隼人、宮城琢也、吉田雄一、巽 智秀、笠原彰紀、林 紀夫、竹原徹郎
    • Organizer
      JDDW2014 第18回肝臓学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2014-10-23 – 2014-10-26
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Genotype1 C型慢性肝炎に対するSimeprevir/Peg-IFN/RBV併用治療の有用性について

    • Author(s)
      小瀬嗣子、平松直樹、藥師神崇行、山田涼子、原田直毅、森下直紀、宮城琢也、吉田雄一、巽 智秀、大川和良、林 紀夫、竹原徹郎
    • Organizer
      肝臓学会総会 (第50回)
    • Place of Presentation
      東京都
    • Year and Date
      2014-05-29 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] Involvement of hepatitis C virus infection in the regulation of chemo-sensitivity of hepatocellular carcinoma cells

    • Author(s)
      Nawa T, Tatsumi T, Nishio A, Tawara S, Onishi Y, Aono S, Hayato Hikita H, Sakamori R, Miyagi T, Hiramatsu N, Takehara T
    • Organizer
      The American Association fore Study of Liver Diseases
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2014-11-07 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-24590973
  • [Presentation] C型肝炎に対するシメプレビル治療における次世代シークエンサーを用いた耐性変異の検討

    • Author(s)
      森下直紀、名和誉敏、原田直毅、山田涼子、清水 聡、疋田隼人、小瀬嗣子、藥師神崇行、宮城琢也、吉田雄一、巽 智秀、大川和良、平松直樹、竹原徹郎
    • Organizer
      肝臓学会総会 (第50回)
    • Place of Presentation
      東京都
    • Year and Date
      2014-05-29 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-24590973
  • 1.  HIKITA Hayato (20623044)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 89 results
  • 2.  TAKEHARA Tetsuo (70335355)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 190 results
  • 3.  Ryotaro Sakamori (10644685)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 26 results
  • 4.  Takahiro Kodama (10623275)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 44 results
  • 5.  HIRAMATSU Naoki (30362700)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 6.  MIYAGI Takuya (80532986)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 19 results
  • 7.  SHIGEKAWA Minoru (00625436)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 8.  OHKAWA Kazuyoshi (80432540)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TANAKA Satoshi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 26 results
  • 10.  Makino Yuki (60771334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 11.  KANTO Tatsuya (80372613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  Kasahara Akinori (70214286)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  NAWA Takatoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 14.  AONO Satoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 15.  IKEZAWA Kenji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SAKANE Sadatsugu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 17.  GAO Nan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  Kazuhiro Murai
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  Yoshioka Teppei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 20.  IWAHASHI Kiyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  SUEYOSHI Hironari
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SAITO Yoshinobu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 23.  URABE Makiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  YOSHIDA Yuuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  ASAHINA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  KONDO Yasuteru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  TADOKORO Seiji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  冨山 佳昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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